A composition with anti-hair loss and oil control functions and a preparation method thereof

Abstract

The present application relates to the field of hair preparations, in particular to a composition with anti-hair loss and oil control functions and a preparation method thereof.The raw materials of the composition include diaminopyrimidine oxide, yeast / zinc fermentation product, nicotinamide, lactobacillus / soybean milk fermentation product filtrate combined with PPG-13-decyltetradecinol polyether-24, PPG-70 polyglyceryl-10 ether, African neem bark extract, Anemarrhena asphodeloides root extract, Panax ginseng root extract, Zingiber officinale root extract, Polygonum multiflorum root extract, humectant, emollient and water.The composition has excellent anti-hair loss and oil control effects, high stability and can still exist stably in a high temperature environment.

Description

Technical Field

[0001] This invention relates to the field of hair care formulation technology, specifically to a composition with anti-hair loss, hair growth, and oil control functions, and its preparation method. Background Technology

[0002] A hair follicle is a sac-like epithelium formed by continuous epidermal cells. Its base is the dermal papilla, an indentation in the dermis, and its center contains a single hair. One side of the arrector pili muscle is obliquely attached to the follicle wall. Above the attachment point is the short neck through which the sebaceous gland enters the follicle. The opening of the follicle on the skin surface is called the follicular pore. Located in the dermis and subcutaneous tissue, the hair follicle can be divided into the infundibulum, isthmus, and lower part. Hair grows from the follicle, absorbing nutrients from the body through it to support growth. The epithelial cells of the hair follicle can divide and multiply, causing continuous hair replacement and growth. However, with age, the function of the hair follicle gradually weakens, leading to hair loss and other problems.

[0003] Hair loss is primarily caused by damage or death of hair follicles due to external stimuli. Current hair loss prevention products vary greatly in quality, have limited effectiveness, and often cause skin irritation or exhibit instability due to their emulsion-like properties. Therefore, providing a composition with excellent hair loss prevention, hair growth, and oil control functions, coupled with good stability, is an urgent technical problem to be solved. Summary of the Invention

[0004] In view of the above-mentioned technical problems, the present invention proposes a technical solution, which includes a composition having the functions of preventing hair loss and promoting hair growth and controlling oil, and a method for preparing the same.

[0005] This invention provides a composition with anti-hair loss and hair growth and oil control functions, the raw materials of which include diaminopyrimidine oxide, yeast / zinc fermentation product, nicotinamide, and lactobacillus / soy milk fermentation product filtrate.

[0006] Preferably, the composition further comprises PPG-13-decyltetradecyl alcohol polyether-24 and PPG-70 polyglycerol-10 ether.

[0007] Preferably, the composition further includes extracts of neem bark, anemarrhena root, ginseng root, ginger root, and polygonum multiflorum root.

[0008] Preferably, the composition further includes water, a humectant, and a skin moisturizer.

[0009] Preferably, the composition comprises, by weight percentage, 0.05-1.2% diaminopyrimidine oxide, 0.05-2% yeast / zinc fermentation product, 0.05-0.5% nicotinamide, 0.05-1.5% lactobacillus / soybean fermentation product filtrate, 1-5% PPG-13-decyltetradecyl alcohol polyether-24, 1-3% PPG-70 polyglycerol-10 ether, 0.05-2% African neem bark extract, 0.05-1.5% anemarrhena asphodeloides root extract, 0.05-1.5% ginseng root extract, 0.05-1.5% ginger root extract, 0.05-1.5% polygonum multiflorum root extract, 4-12% humectant, 4-10% emollient, and the balance being water.

[0010] This invention uses diaminopyrimidine oxide, yeast / zinc fermentation product, lactobacillus / soy milk fermentation product filtrate, African neem bark extract, anemarrhena root extract, ginseng root extract, ginger root extract, and polygonum multiflorum root extract as raw materials, which have the effects of preventing hair loss, promoting hair growth, and controlling oil, to give the composition the effects of preventing hair loss, promoting hair growth, and controlling oil.

[0011] Preferably, in the composition, the mass ratio of PPG-13-decyltetradecyl alcohol polyether-24 to PPG-70 polyglycerol-10 ether is 1.2-2.5:1. This combination effectively promotes and delivers the active ingredients of the composition to the recipient skin, enhances the efficacy of the active ingredients, and also imparts excellent stability to the composition.

[0012] Preferably, the moisturizer in the composition includes at least one of glycerin, propylene glycol, ethylene glycol, butylene glycol, 1,2-hexanediol, dextran, and sodium hyaluronate.

[0013] Preferably, the emollient in the composition includes at least one of phytosterol / octyldodecyl lauroyl glutamate, coconut oil, avocado oil, hydrogenated palm oil, camellia oil, and jojoba oil.

[0014] Preferably, in the composition, the mass ratio of diaminopyrimidine oxide to neem bark extract is 1:0.6-1.2. Diaminopyrimidine oxide and neem bark extract in the composition can effectively enhance the composition's effect in preventing hair loss, giving the composition excellent anti-hair loss and hair regrowth effects.

[0015] Preferably, the composition further includes at least one of a preservative, a pigment, a fragrance, a chelating agent, and a pH adjuster.

[0016] Preferably, the amount of preservative in the composition is 0.01-0.4%. The preservative may be at least one of phenoxyethanol and benzoate.

[0017] Preferably, the amount of pigment in the composition is 0.005-0.1%.

[0018] Preferably, the amount of fragrance in the composition is 0.005-0.1%.

[0019] Preferably, the chelating agent is used in the composition at an amount of 0.05-1%. The chelating agent may be at least one of EDTA and its salts, or citrate.

[0020] Preferably, the amount of pH adjuster in the composition is 0.1-1%. The pH adjuster may be at least one of citric acid, malic acid, lactic acid, and tartaric acid.

[0021] The present invention also provides a method for preparing the composition, comprising mixing raw materials to obtain the composition.

[0022] Preferably, the preparation method further includes a sterilization step.

[0023] The present invention also provides the use of the composition in the preparation of cosmetic or hair care pharmaceutical formulations.

[0024] The beneficial effects of this invention are:

[0025] This invention utilizes diaminopyrimidine oxide, yeast / zinc fermentation product, nicotinamide, lactobacillus / soybean milk fermentation product filtrate, combined with PPG-13-decyltetradecyl alcohol polyether-24, PPG-70 polyglycerol-10 ether, African neem bark extract, anemarrhena root extract, ginseng root extract, ginger root extract, polygonum multiflorum root extract, moisturizers, skin moisturizers, and other raw materials with functions such as preventing hair loss and promoting hair growth, and controlling oil, to prepare a composition with excellent effects in preventing hair loss and promoting hair growth, controlling oil, high stability, and still stable in high temperature environments.

[0026] The composition of the present invention promotes the darkening of the skin area in hair-removed mice in 150.3±18.4 hours and promotes the regrowth of hair in the hair-removed area in 242.4±22.1 hours; the composition of the present invention can advance the darkening of the skin area in hair-removed mice by 73.4 hours and promote the regrowth of hair in the hair-removed area by 71.7 hours; the composition of the present invention has excellent hair growth promotion and good hair removal inhibition effect.

[0027] The ZETA potential of the composition of the present invention diluted 40 times reaches -49.75mV; after the diluted solution is placed at 50°C for 2 days, the ZETA potential reaches -43.67mV; the composition of the present invention has good stability and good shelf life.

[0028] The ingredients used in this invention, such as aminopyrimidine oxide, PPG-70 polyglycerol-10 ether, PPG-13-decyltetradecyl alcohol polyether-24, African neem bark extract, Anemarrhena asphodeloides root extract, and ginseng root extract, have a promoting effect on the combined anti-hair loss effect.

[0029] This invention uses a combination of aminopyrimidine oxide and African neem bark extract to enhance the anti-hair loss effect of the composition; and the effect is even better when the ratio is 1:0.6-1.2.

[0030] In this invention, PPG-70 polyglycerol-10 ether and PPG-13-decyltetradecyl alcohol polyether-24 affect the hair loss prevention and stability of the composition. The combination of the two can synergistically promote the delivery and absorption of the active ingredients of the product, giving the composition excellent hair loss prevention and stability effects. The composition prepared with the ratio of the two at 1.2-2.5:1 has better hair loss prevention and stability.

[0031] The composition of this invention has excellent effects, is simple to prepare, and has good application prospects; moreover, the product has good stability and can be stored for a long time. Detailed Implementation

[0032] The present invention will be described below with reference to specific embodiments, thereby making the various effects of the invention clearer. Those skilled in the art should understand that these specific embodiments are for illustrative purposes only and not for limiting the invention.

[0033] The raw material information used in this invention is as follows:

[0034] Diaminopyrimidine oxide: Molecular formula C4H6N4O, Zhuhai Bairui Pharmaceutical Technology Co., Ltd. Yeast / Zinc fermentation product: Angel Yeast Co., Ltd. Nicotinamide: Jiangxi Haiwen Biotechnology Co., Ltd. Lactobacillus / Soy milk fermentation product filtrate: Xianting Guangzhou Trading Co., Ltd. Sodium hyaluronate: Hybloom TM Low molecular weight sodium hyaluronate (HA-TLM 3-5S), Bloomage Biotechnology Co., Ltd.

[0035] African neem bark extract: African neem bark was pulverized to a particle size of less than 100 mesh, and 20 times its weight of 40% ethanol aqueous solution was added. The mixture was heated to 60°C and stirred at 60 rpm for 4 hours. Then it was cooled to room temperature and filtered using a 0.5-micron pore size filter membrane. The filtrate was ultrafiltered using an ultrafiltration membrane with a molecular weight cutoff of 1000 Da. The ultrafiltrate was freeze-dried at -40°C to a water content of 2.78 wt%.

[0036] Anemarrhena asphodeloides root extract: Anemarrhena asphodeloides root was pulverized to a particle size of less than 120 mesh, 25 kg of water was added, and the mixture was boiled. Then it was heated at 85°C for 5 hours, with water added every 30 minutes until the initial volume was reached. The mixture was stirred at 50 rpm during the heating process. The mixture was then cooled to room temperature and filtered through a 0.5-micron pore size filter membrane. The filtrate was then ultrafiltered using an 800 Da molecular weight cutoff ultrafiltration membrane. The ultrafiltrate was freeze-dried at -35°C until the water content was 2.91 wt%.

[0037] The preparation methods for ginseng root extract, ginger root extract, and Polygonum multiflorum root extract are as follows: The plant raw materials (ginseng root, ginger root, and Polygonum multiflorum root) are pulverized to less than 150 mesh, and 22 times their weight of 55wt% ethanol aqueous solution is added. The mixture is stirred at 58℃ and 65rpm for 5.2 hours, then cooled to room temperature, and filtered through a 0.5-micron pore size filter membrane to obtain a coarse filtrate. The coarse filtrate is then ultrafiltered through a 1000Da molecular weight cutoff ultrafiltration membrane, and the ultrafiltrate is freeze-dried at -40℃ to a water content of 3.14wt%.

[0038] The specific information on the raw materials and dosages of the composition is shown in Table 1-2.

[0039] Table 1: Raw material composition of the composition

[0040]

[0041]

[0042]

[0043] Table 2: Raw material composition of the composition

[0044]

[0045]

[0046]

[0047] The above composition is prepared as follows: humectant, emollient, water, PPG-13-decyltetradecyl alcohol polyether-24, and PPG-70 polyglycerol-10 ether are placed in a container, heated to 62°C and stirred at 800 rpm for 0.5 hours; the temperature is lowered to 45°C, the remaining raw materials are added, stirring is continued for 0.4 hours, cooled to room temperature, allowed to stand for 2 hours, and sterilized to obtain the composition.

[0048] The above composition was subjected to performance testing.

[0049] 1. Anti-hair loss effect test

[0050] A mouse hair loss model was established, and the drug was administered. The time it took for the skin in the hair loss area to turn from pink to black and for hair to grow back were tested. The time values ​​of this test were used to measure the anti-hair loss effect of the composition. The shorter the time, the better the effect of promoting hair growth and inhibiting hair loss.

[0051] The specific testing process is as follows:

[0052] Step 1: Select healthy male C57BL / 6 mice weighing 24±2g and acclimatize them for 3 days. Anesthetize the mice and then remove hair from a uniform 2.5cm long and wide area on their backs. On the second day after hair removal, mice with smooth skin and no wounds in the hair removal area were divided into 15 groups: blank control group, model group, positive drug control group, and combination groups 1-12, with 10 mice in each group.

[0053] Step 2: The blank control group mice were not treated in any way. The hair removal areas of the mice in the other groups were coated with 125 μL of 0.052 wt% testosterone solution once a day for 15 consecutive days. All mice in the groups were fed and given water normally.

[0054] Step 3: Two hours after the last application of testosterone solution, the drug application was performed. The blank control group and the model group received no treatment. The positive drug control group received 120 μL of 2.4% finasteride solution on the hair removal area. The combination groups received 120 μL of the corresponding combination 1-12 on the hair removal area. The application was performed once a day for 15 consecutive days. All mice were fed and given water normally.

[0055] Step 4: After the application of the medication, observe the skin and hair growth in the hair-removed areas of each group of mice, and record the time (T1) when the skin color in the hair-removed area of ​​each mouse in each group changes from pink to black and the time (T2) when hair begins to grow. Specific test results are shown in Table 3.

[0056] Table 3: T1 and T2 for each group

[0057]

[0058]

[0059] Based on the test data in Table 3, the advance time values ​​ΔT1 and ΔT2 of each group compared to the model group were calculated to measure the difference in experimental performance between the groups. The results are shown in Table 4.

[0060] Table 4: ΔT1 and ΔT2 of each group compared to the model group

[0061]

[0062]

[0063] 2. Stability Test

[0064] The above composition was diluted 40 times with ultrapure water, stirred at 30°C and 400 rpm for half an hour, cooled to room temperature, and the zeta potential was tested. The results are shown in Table 5.

[0065] Table 5: Zeta potential of diluent

[0066] test ZETA potential / mV Composition 1 -49.75 Composition 2 -48.37 Composition 3 -20.17 Composition 9 -43.64 Composition 10 -45.97 Composition 11 -48.01 Composition 12 -46.53

[0067] After the above tests were conducted, the diluted solutions were placed at 50°C for 2 days, and the ZETA potential of each diluted solution was tested again. The test results are shown in Table 6.

[0068] Table 6: Zeta potentials after 7 days at 50℃

[0069] test ZETA potential / mV Composition 1 -43.67 Composition 2 -41.28 Composition 3 -12.37 Composition 9 -36.21 Composition 10 -38.48 Composition 11 -40.81 Composition 12 -39.52

[0070] According to the test results in Table 3-6, the composition of the present invention has excellent anti-hair loss effect and excellent stability, and can still exist stably in high temperature environment.

[0071] Tests showed that the composition of the present invention promoted the darkening of the skin area in hair-removed mice in 150.3±18.4 hours and promoted the regrowth of hair in the hair-removed area in 242.4±22.1 hours; the composition of the present invention promoted the darkening of the skin area in hair-removed mice earlier by 73.4 hours and promoted the regrowth of hair in the hair-removed area in 71.7 hours; the composition of the present invention has excellent hair growth promotion and good hair removal inhibition effect.

[0072] The ZETA potential of the composition of the present invention diluted 40 times reaches -49.75mV; after the diluted solution is placed at 50°C for 2 days, the ZETA potential reaches -43.67mV; the composition of the present invention has good stability and good shelf life.

[0073] The test results of compositions 1, 3, and 8 show that the aminopyrimidine oxide, PPG-70 polyglycerol-10 ether, PPG-13-decyltetradecyl alcohol polyether-24, African neem bark extract, Anemarrhena asphodeloides root extract, ginseng root extract, and other ingredients used in this invention have a promoting effect on the combined anti-hair loss effect.

[0074] The test results of compositions 1, 4-7 show that the combination of aminopyrimidine oxide and African neem bark extract in this invention can enhance the anti-hair loss effect of the composition; and the effect is better when the ratio is 1:0.6-1.2.

[0075] Tests on compositions 1, 9, and 12 showed that PPG-70 polyglycerol-10 ether and PPG-13-decyltetradecyl alcohol polyether-24 affected the composition's anti-hair loss and stability. The combination of the two can synergistically promote the delivery and absorption of the product's active ingredients, giving the composition excellent anti-hair loss and stability effects. The composition prepared with a ratio of 1.2-2.5:1 has better anti-hair loss and stability.

[0076] The composition of this invention has excellent effects, is simple to prepare, and has good application prospects; moreover, the product has good stability and can be stored for a long time.

[0077] Obviously, those skilled in the art can make various modifications and variations to this invention without departing from its spirit and scope. Therefore, if these modifications and variations fall within the scope of the claims of this invention and their equivalents, this invention also intends to include these modifications and variations.

Claims

1. A composition having anti-hair loss and hair growth and oil control functions, characterized in that, By weight percentage, the raw materials include 0.05-1.2% diaminopyrimidine oxide, 0.05-2% yeast / zinc fermentation product, 0.05-0.5% nicotinamide, 0.05-1.5% lactobacillus / soybean milk fermentation product filtrate, 1-5% PPG-13-decyltetradecyl alcohol polyether-24, 1-3% PPG-70 polyglycerol-10 ether, 0.05-2% African neem bark extract, 0.05-1.5% anemarrhena asphodeloides root extract, 0.05-1.5% ginseng root extract, 0.05-1.5% ginger root extract, 0.05-1.5% polygonum multiflorum root extract, 4-12% humectant, 4-10% emollient, and the balance being water; The mass ratio of PPG-13-decyltetradecyl alcohol polyether-24 to PPG-70 polyglycerol-10 ether is 1.2-2.5:1; the mass ratio of diaminopyrimidine oxide to African neem bark extract is 1:0.6-1.

2. Preparation method of African neem bark extract: African neem bark is pulverized to a particle size of less than 100 mesh, 20 times the mass concentration of 40% ethanol aqueous solution is added, heated to 60℃, stirred at 60 rpm for 4 hours, then cooled to room temperature, and then filtered using a 0.5 micron pore size filter membrane. The filtrate is ultrafiltered using an ultrafiltration membrane with a molecular weight cutoff of 1000 Da, and the ultrafiltrate is freeze-dried at -40℃ to a water content of 2.78 wt%.

2. A method for preparing the composition according to claim 1, characterized in that, This includes mixing the raw materials to obtain the composition.

3. The use of the composition according to claim 1 in the preparation of cosmetic or hair care pharmaceutical formulations.

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