Traditional Chinese medicine for effectively reversing ovarian aging

Abstract

The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine for effectively reversing ovary senescence. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20-40 parts of astragalus membranaceus, 5-6 parts of kudzu vine roots, 10-15 parts of prepared rehmannia roots, 8-10 parts of poria cocos, 12-16 parts of angelica sinensis, 6-9 parts of ligusticum wallichii, 8-12 parts of acanthopanax roots, 8-10 parts of asparagus fern and 10-15 parts of liquorice. According to the traditional Chinese medicine composition, various raw materials such as radix astragali, radix puerariae and radix rehmanniae praeparata are selected, mouse experiments find that the content of estradiol E2 can be increased, reduction of the concentration of estradiol E2 is one of the characteristics of premature ovarian failure, the content of estradiol E2 can be increased, and it is indicated that the traditional Chinese medicine composition can effectively relieve or reverse ovarian aging; the traditional Chinese medicine composition is prepared from multiple selected traditional Chinese medicine raw materials, treats both symptoms and root causes and is small in side effect.

Description

Technical Field

[0001] The invention belongs to the technical field of Chinese medicine compositions, and particularly relates to a Chinese medicine that effectively reverses ovarian aging. Background Art

[0002] Premature ovarian failure refers to a type of gynecological disease in which the ovarian function of women before the age of 40 is weakened, characterized by increased serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) concentrations and decreased estradiol (E2) concentrations. The occurrence of this disease not only affects the patient's normal life, but also affects the patient's mental health. In recent years, the incidence of premature ovarian failure has increased year by year and has a trend of becoming younger. The incidence rate of women under 40 years old is 1-3%, and the incidence rate of women under 30 years old is about 0.1%.

[0003] At present, Western medicine hormone drugs are mainly used to treat premature ovarian failure, but Western medicine hormone drugs are mostly symptomatic and not fundamental, and are prone to recurrence, which will aggravate the psychological impact on patients. At the same time, long-term use of Western medicine hormone drugs is likely to cause endocrine disorders in the patient's own body and damage to internal organs. my country has rich Chinese herbal medicine resources. Although Chinese medicine has a slow effect, it treats both the symptoms and the root cause, is not easy to relapse, and has little side effects on patients. Therefore, a Chinese medicine composition that effectively reverses ovarian aging is needed.

[0004] The information disclosed in this background technology section is only intended to enhance the understanding of the overall background of the invention and should not be regarded as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to a person skilled in the art. Summary of the invention

[0005] The purpose of the present invention is to provide a traditional Chinese medicine that can effectively reverse ovarian aging, so as to solve the problems existing in the background art of using Western medicine hormone drugs to treat premature ovarian failure.

[0006] To achieve the above object, the present invention provides the following technical solutions:

[0007] A traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20-40 parts of astragalus, 5-6 parts of kudzu root, 10-15 parts of rehmannia root, 8-10 parts of tuckahoe, 12-16 parts of angelica, 6-9 parts of chuanxiong, 8-12 parts of acanthopanax, 8-10 parts of asparagus and 10-15 parts of liquorice.

[0008] Preferably, the Chinese medicine composition is prepared from the following raw materials, by weight: 26 parts of Astragalus, 6 parts of Pueraria, 13 parts of Rehmannia, 9 parts of Poria, 14 parts of Angelica, 8 parts of Chuanxiong, 10 parts of Acanthopanax, 10 parts of Asparagus and 15 parts of Licorice.

[0009] Preferably, the Chinese medicine composition is prepared from the following raw materials, by weight: 38 parts of Astragalus, 5 parts of Pueraria, 14 parts of Rehmannia glutinosa, 10 parts of Poria, 16 parts of Angelica sinensis, 9 parts of Chuanxiong, 12 parts of Acanthopanax senticosus, 10 parts of Asparagus cochinchinensis and 15 parts of Licorice.

[0010] Preferably, the Chinese medicine composition is prepared from the following raw materials, by weight: 22 parts of Astragalus, 5 parts of Pueraria, 12 parts of Rehmannia glutinosa, 8 parts of Poria, 12 parts of Angelica sinensis, 6 parts of Chuanxiong, 8 parts of Acanthopanax senticosus, 8 parts of Asparagus cochinchinensis and 10 parts of Licorice.

[0011] The present invention also provides application of the traditional Chinese medicine composition in alleviating or reversing ovarian aging.

[0012] The present invention also provides a traditional Chinese medicine preparation, which is prepared from the traditional Chinese medicine composition.

[0013] Preferably, the preparation method of the Chinese medicine preparation comprises the following steps:

[0014] S1. Take the raw material of the Chinese medicine composition, add 10-12 times the weight of water and soak for 1-2h, heat and boil for 0.5-1h, filter and collect the filtrate;

[0015] S2 another device to collect the residue, add the raw material of the Chinese medicine composition 6-8 weight of water, heated to boil and maintained for 0.5-1h, filtered, and the filtrate was collected;

[0016] S3. The filtrates are combined and concentrated to obtain an extract, which is spray-dried to obtain a powder to obtain the Chinese medicine preparation.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] The Chinese medicine of the present invention selects multiple raw materials such as astragalus, kudzu root and rehmannia root, and it is found through mouse experiments that the content of estradiol E2 can be increased, and a decrease in the concentration of estradiol E2 is one of the characteristics of premature ovarian failure. The Chinese medicine of the present invention can increase the content of estradiol E2, indicating that the Chinese medicine composition of the present invention can effectively alleviate or reverse ovarian aging, and the Chinese medicine composition of the present invention is prepared from multiple selected Chinese medicine raw materials, has a therapeutic effect on both the symptoms and the root cause, and has little side effects. DETAILED DESCRIPTION

[0019] The following is a clear and complete description of the technical solution of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by technicians in this field without creative work are within the scope of protection of the present invention.

[0020] Example 1

[0021] A traditional Chinese medicine composition is prepared from the following raw materials by weight: 26g of Astragalus, 6g of Pueraria, 13g of Rehmannia glutinosa, 9g of Poria, 14g of Angelica sinensis, 8g of Chuanxiong, 10g of Acanthopanax senticosus, 10g of Asparagus cochinchinensis and 15g of Licorice.

[0022] The method for preparing the above-mentioned Chinese medicine composition into a Chinese medicine preparation comprises the following steps:

[0023] S1. Take the raw material of the Chinese medicine composition, add 12 times the weight of water and soak for 2h, heat and boil for 1h, filter and collect the filtrate;

[0024] S2 another device to collect the residue, add the raw material of the Chinese medicine composition 8 weight of water, heated to boil and maintained for 0.5h, filtered, and the filtrate was collected;

[0025] S3. The filtrates are combined and concentrated to obtain an extract, which is spray-dried to obtain a powder to obtain the Chinese medicine preparation.

[0026] Example 2

[0027] A traditional Chinese medicine composition is prepared from the following raw materials by weight: 38g of astragalus, 5g of kudzu root, 14g of rehmannia root, 10g of tuckahoe, 16g of angelica, 9g of chuanxiong, 12g of acanthopanax, 10g of asparagus and 15g of liquorice.

[0028] The method for preparing the above Chinese medicine composition into a Chinese medicine preparation is the same as that in Example 1.

[0029] Example 3

[0030] A Chinese medicine composition comprises, by weight, 22g of astragalus, 5g of kudzu root, 12g of rehmannia root, 8g of tuckahoe, 12g of angelica, 6g of chuanxiong, 8g of acanthopanax senticosus, 8g of asparagus cochinchinensis and 10g of liquorice.

[0031] The method for preparing the above Chinese medicine composition into a Chinese medicine preparation is the same as that in Example 1.

[0032] Effect experiment

[0033] Healthy purebred female Kunming mice (45-52 days old, weighing 200-230 g / mouse) were selected as experimental subjects, and the experiment was started after 1 week of adaptive feeding. The mice were randomly divided into a research group and a control group, with 15 mice in each group. The research group was gavaged with 1.3674 g / 100 g of the Chinese medicine preparation of Example 1, and the control group was gavaged with an equal amount of normal saline.

[0034] After 7 days of intragastric administration, the serum estradiol E2 content was determined by Elisa method. The specific method of estradiol E2 determination refers to the method disclosed in the existing patent CN110214955B. The results are shown in Table 1.

[0035] Table 1 Effect of the Chinese medicine composition of the present invention on the serum estradiol E2 content of mice

[0036] Group Number of mice Serum estradiol E2 content (ng / L) Research Group 15 143.6 Control group 15 62.1

[0037] As shown in Table 1, the serum estradiol E2 content of mice in the control group was 62.1 ng / L, and the serum estradiol E2 content of mice in the study group was 143.6 ng / L, which was significantly higher in the study group than in the control group. Decreased estradiol E2 concentration is one of the characteristics of premature ovarian failure. The invented Chinese medicine can increase the estradiol E2 content, indicating that the Chinese medicine composition of the present invention can effectively alleviate or reverse ovarian aging, and the Chinese medicine composition of the present invention is prepared from a variety of selected Chinese medicine raw materials, treating both the symptoms and the root causes, and having few side effects.

[0038] The foregoing description of specific exemplary embodiments of the present invention is for the purpose of illustration and demonstration. These descriptions are not intended to limit the present invention to the precise form disclosed, and it is clear that many changes and variations can be made based on the above teachings. The purpose of selecting and describing the exemplary embodiments is to explain the specific principles of the present invention and its practical application, so that those skilled in the art can realize and utilize various different exemplary embodiments of the present invention and various different selections and changes. The scope of the present invention is intended to be limited by the claims and their equivalents.

Claims

1. A Chinese medicine composition, characterized in that: The traditional Chinese medicine composition is prepared from the following raw materials by weight: 20-40 parts of astragalus, 5-6 parts of kudzu root, 10-15 parts of rehmannia root, 8-10 parts of tuckahoe, 12-16 parts of angelica, 6-9 parts of chuanxiong, 8-12 parts of acanthopanax, 8-10 parts of asparagus and 10-15 parts of liquorice.

2. The Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition is prepared from the following raw materials by weight: 26 parts of astragalus, 6 parts of kudzu root, 13 parts of rehmannia root, 9 parts of tuckahoe, 14 parts of angelica, 8 parts of chuanxiong, 10 parts of acanthopanax, 10 parts of asparagus and 15 parts of liquorice.

3. The Chinese medicine composition according to claim 1, characterized in that The Chinese medicine composition is prepared from the following raw materials by weight: 38 parts of astragalus, 5 parts of kudzu root, 14 parts of rehmannia root, 10 parts of tuckahoe, 16 parts of angelica, 9 parts of chuanxiong, 12 parts of acanthopanax, 10 parts of asparagus and 15 parts of liquorice.

4. The Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition is prepared from the following raw materials by weight: 22 parts of astragalus, 5 parts of kudzu root, 12 parts of rehmannia root, 8 parts of tuckahoe, 12 parts of angelica, 6 parts of chuanxiong, 8 parts of acanthopanax, 8 parts of asparagus and 10 parts of liquorice.

5. Use of the Chinese medicine composition according to any one of claims 1 to 4 in alleviating or reversing ovarian aging.

6. A Chinese medicine preparation, characterized in that: The traditional Chinese medicine preparation is prepared from the traditional Chinese medicine composition according to any one of claims 1 to 4.

7. The Chinese medicine preparation according to claim 6, characterized in that: The preparation method comprises the following steps: S1. Take the raw material of the Chinese medicine composition, add 10-12 times the weight of water and soak for 1-2h, heat and boil for 0.5-1h, filter and collect the filtrate; S2 another device to collect the residue, add the raw material of the Chinese medicine composition 6-8 weight of water, heated to boil and maintained for 0.5-1h, filtered, and the filtrate was collected; S3. The filtrates are combined and concentrated to obtain an extract, which is spray-dried to obtain a powder to obtain the Chinese medicine preparation.