Device for adjusting powder and mixing powder

Abstract

The invention discloses a device for adjusting and mixing powder, and belongs to the technical field of powder engineering. The device consists of a heating dehumidifier, a gas heater, a liquid storage tank, a peristaltic pump, a liquid atomizer, a buffer tank and a cyclone separator, and can effectively solve the problem of instability caused by static electricity and powder character change in the micronization process. By adjusting the temperature, the humidity, the flow velocity and the components of the airflow, the device can eliminate static electricity carried by the powder, change the surface shape of the powder and achieve the purpose of stabilizing the characters of the powder. In addition, the device realizes uniform mixing of various powders by utilizing centrifugal force generated by air flow, so that the consistency and quality of products are improved. The method has wide application prospects in the fields of medicine, electronics, energy, chemical engineering and the like, is particularly suitable for the production process of dry powder inhalation medicines, and improves the production efficiency and ensures the product quality by quickly adjusting the powder characteristics.

Description

Technical Field

[0001] The invention belongs to the technical field of powder engineering, and in particular relates to a device for regulating powder and mixing powder. Background Art

[0002] In recent years, with the continuous advancement of pulmonary inhalation drug delivery technology, dry powder inhalation drugs have achieved remarkable results in the treatment of asthma and chronic obstructive pulmonary disease. This type of drug has attracted widespread attention due to its advantages such as rapid onset of action, small dosage, few side effects, easy to carry, easy to operate and store. However, the research and development and production process of dry powder inhalation drugs faces many challenges, especially in the micronization process, factors such as static electricity problems, powder morphology changes, and pulverization process parameters will affect the delivery effect and stability of the finished product. Therefore, after micronization, it is crucial to properly adjust the powder to meet subsequent research and development and production needs.

[0003] The challenges of dry powder inhalation medications are as follows:

[0004] Static electricity problem: During the micronization process, static electricity is easily generated between powder particles. This static electricity not only causes particle aggregation, but also may affect the dispersion and uniformity of the drug during inhalation, thereby affecting the efficacy of the drug.

[0005] Changes in powder morphology: During the micronization process, especially by air flow milling, amorphous particles will be formed. These particles will affect drug delivery and stability in terms of aerodynamics, hygroscopicity, and electrostatic properties.

[0006] At present, in order to solve the above problems, a variety of equipment for regulating and mixing powders have appeared on the market. These equipment usually improve powder properties by adjusting parameters such as gas flow rate, temperature, and humidity. For example, a heated dehumidifier can reduce gas humidity; a cyclone separator uses centrifugal force to achieve material movement and mixing. However, these methods usually take a long time to achieve the desired effect, and the equipment parameters may need to be adjusted frequently when processing different types of powders.

[0007] The present invention proposes a novel device for quickly adjusting the properties of powders and achieving uniform mixing of multiple powders. The device combines multiple components such as a heating dehumidifier, a gas heater, a liquid storage tank, a peristaltic pump, a liquid atomizer, a buffer tank, and a cyclone separator. By precisely controlling the temperature, humidity, flow rate, and composition of the airflow, the surface shape and electrostatic properties of the powder can be adjusted.

[0008] Its main components are as follows:

[0009] -Heated dehumidifier: reduces the humidity of the gas.

[0010] -Gas Heater: Heats the gas to a set temperature to increase the airflow carrying capacity.

[0011] -Liquid atomizer: atomizes the liquid into tiny droplets, mixes with the air flow and then sprays it into the buffer tank.

[0012] -Cyclone separator: uses centrifugal force to achieve material movement and mixing.

[0013] The device adjusts the airflow parameters so that the micronized powder can be processed in a stable state. Compared with traditional methods, the device can complete the adjustment process more quickly and is suitable for a variety of powder types.

[0014] This new device has significant advantages in the pharmaceutical field, especially in the production of dry powder inhalation drugs. In addition, the device also shows good application potential in food processing, chemical production, and electronic material preparation. By optimizing the equipment design and operating parameters, its efficiency and effectiveness in practical applications can be further improved.

[0015] In summary, the present invention provides an efficient and flexible solution to solve a series of challenges currently faced in powder engineering. Through innovative design, the device not only improves production efficiency, but also significantly improves product quality, providing new technical support for the development of related industries. Summary of the invention

[0016] Problem to be solved

[0017] The present invention aims to solve multiple problems existing in the field of powder engineering, especially in the production process of dry powder inhalation drugs. By designing a device for adjusting powder properties and achieving uniform mixing of powders, the present invention can effectively deal with challenges such as static electricity problems, particle morphology changes, and insufficient mixing uniformity that occur during the micronization process.

[0018] The problems to be solved are as follows:

[0019] Static electricity elimination: Static electricity accumulation is a common problem during the powder micronization process. This not only causes particle aggregation, but may also affect the dispersion and uniformity of the drug during inhalation, thereby reducing the efficacy of the drug. By using a heated dehumidifier and a gas heater, the present invention is able to regulate the humidity and temperature of the gas, thereby effectively eliminating the static electricity carried by the powder.

[0020] Stable particle morphology: During the micronization process, the particle morphology may change, affecting its flowability and surface properties. By precisely controlling airflow parameters (such as flow rate, temperature and humidity), the present invention can improve the particle morphology and keep it stable during subsequent processing.

[0021] Improved mixing uniformity: Uniform mixing of multiple powders is the key to producing high-quality dry powder inhalation drugs. The present invention utilizes the centrifugal force generated by the cyclone separator to achieve uniform mixing between different powders, thereby improving the consistency and quality of the product.

[0022] Improved production efficiency: Traditional methods usually take a long time to adjust powder properties, while the present invention achieves rapid adjustment through high-speed airflow, significantly shortening the processing time and improving production efficiency.

[0023] Wide range of applications: In addition to the pharmaceutical field, the present invention also has broad application prospects in many fields involving powder engineering, such as food processing, chemical production, and electronic material preparation. By optimizing equipment design and operating parameters, its efficiency and effect in practical applications can be further improved.

[0024] The present invention is mainly composed of the following components:

[0025] Heated dehumidifier: used to reduce the humidity of the gas.

[0026] Gas heater: used to heat the gas to a set temperature and increase the airflow carrying capacity.

[0027] Liquid storage tank and peristaltic pump: used to store and transport regulating liquid.

[0028] Liquid atomizer: Atomizes liquid into tiny droplets and mixes them with air flow.

[0029] Buffer tank: used to mix dried gas and fine droplets, and to monitor and adjust gas flow parameters through sensors.

[0030] Cyclone separator: uses centrifugal force to achieve material movement and mixing, so as to adjust powder properties, eliminate static electricity and mix materials.

[0031] The invention not only has significant advantages in the field of medicine, but also shows good application potential in many fields involving powder engineering, such as food, chemical industry, electronics, new materials, etc. Through innovative design, the device not only improves production efficiency, but also significantly improves product quality, providing new technical support for the development of related industries.

[0032] Technical Solution

[0033] To solve the above problems, the present invention adopts the following technical solutions.

[0034] A device for regulating powder and for mixing powder, the device comprising a heating dehumidifier, a gas heater, a liquid storage tank, a peristaltic pump, a liquid atomizer, a buffer tank, and a cyclone separator;

[0035] The heating dehumidifier, the gas heater, the liquid storage tank, the peristaltic pump, the liquid atomizer, the buffer tank and the cyclone separator are connected in sequence through pipelines.

[0036] The heating dehumidifier is used to reduce the humidity of the compressed gas to below 30% RH.

[0037] The gas heater is used to heat the gas from the heating dehumidifier to a set temperature;

[0038] The liquid storage tank is used to store the solution required for atomization by the liquid atomizer;

[0039] The peristaltic pump is used to transport the solution in the liquid storage tank to the liquid atomizer;

[0040] The liquid atomizer is used to atomize the solution from the liquid storage tank and transport it to the buffer tank;

[0041] The buffer tank is used to mix the gas from the gas heater and the gas from the liquid atomizer;

[0042] The cyclone separator is used to utilize the gas from the buffer tank to drive the movement of materials.

[0043] Preferably, the heating dehumidifier is used to reduce the humidity of the compressed gas to 10% RH;

[0044] The heating dehumidifier includes a heat source, a drying tower A, a drying tower B and a three-way valve A. The heat source is used to heat the adsorption filler of the drying tower A and the adsorption filler of the drying tower B to a preset temperature. The drying tower A and the drying tower B are used to absorb moisture in the gas from the three-way valve A.

[0045] Preferably, the heating method of the heat source is electric heating or microwave heating;

[0046] The three-way valve A is used to control the gas flow to the drying tower A or the drying tower B.

[0047] Preferably, the buffer tank is provided with a sensor, an air pump and a three-way valve B, and the sensor, the air pump and the three-way valve B are connected in sequence. The sensor is used to monitor the parameters of the gas from the buffer tank and control the three-way valve B leading to the cyclone separator according to the parameters. The air pump is used to control the flow rate and pressure of the gas leading to the cyclone separator.

[0048] Preferably, the three-way valve B is also connected to the buffer tank and the liquid atomizer.

[0049] Preferably, the cyclone separator comprises a cone, a silo and a dust collector, the dust collector is connected to the cone, and the silo is arranged below the cone.

[0050] Preferably, the cone receives gas from the three-way valve B and circulates the gas in the cavity of the cone to generate centrifugal force to drive the material to move.

[0051] Preferably, the silo is used to store materials and receive the centrifugal force of the gas from the cone.

[0052] Preferably, the dust collector is used to collect fugitive dust from the silo.

[0053] Beneficial Effects

[0054] Compared with the prior art, the present invention has the following beneficial effects:

[0055] (1) Rapid adjustment of powder properties: The present invention can rapidly adjust the surface shape and electrostatic properties of powders through the specific conditions of high-speed airflow. Compared with traditional methods, which require a long time to achieve the desired effect, the present invention can achieve the stabilization of powder properties more quickly and significantly improve production efficiency, which is particularly important in the production of dry powder inhalation drugs in the pharmaceutical field.

[0056] (2) Elimination of static electricity: During the micronization process, the powder is prone to static electricity, which affects fluidity and uniformity. By heating the dehumidifier to reduce gas humidity and adjust air flow parameters, the present invention can effectively eliminate the static electricity carried by the powder, ensuring the dispersion and uniformity of the drug during inhalation.

[0057] (3) Improvement of particle morphology: During the micronization process, the particle morphology may change, affecting its surface properties and fluidity. The present invention can improve the particle morphology by precisely controlling the airflow parameters, so that it remains stable during subsequent processing, thereby ensuring that the drug has a good delivery effect during the inhalation process.

[0058] (4) Improve mixing uniformity: Mixing multiple powders is a complex process that requires precise control of environmental parameters to ensure mixing effects. The present invention utilizes the centrifugal force generated by the cyclone separator to achieve uniform mixing of multiple powders, thereby improving product consistency and quality.

[0059] (5) Wide application scope: In addition to the pharmaceutical field, the present invention also shows good application prospects in fields involving powder engineering such as food processing, chemical production, and electronic material preparation. By optimizing equipment design and operating parameters, its efficiency and effect in practical applications can be further improved.

[0060] (6) Improving drug stability: By adjusting the powder properties, the present invention can stabilize the properties of the drug after micronization, reduce the deterioration of the drug during storage and transportation, and ensure the quality and stability of the finished product.

[0061] (7) Reducing dust pollution: The device of the present invention can capture and collect the fine dust generated during the micronization process, reduce dust pollution, and protect the cleanliness of the production environment.

[0062] (8) Easy and safe operation: The design of the device takes into account the ease of operation and safety. Through the automated control and monitoring system, manual intervention is reduced, human errors in the production process are reduced, and production safety is improved.

[0063] (9) Energy saving and environmental protection: The present invention can reduce energy consumption by precisely controlling airflow parameters, thus embodying the concepts of environmental protection and energy saving.

[0064] Through the above-mentioned beneficial effects, the present invention provides an efficient and flexible solution for the field of powder engineering technology, significantly improves production efficiency and product quality and expands the scope of application, providing new technical support for the development of related industries. BRIEF DESCRIPTION OF THE DRAWINGS

[0065] Figure 1 This is a diagram of a device for adjusting powders and mixing powders in the present invention.

[0066] In the figure: 1-heating dehumidifier; 2-gas heater; 3-liquid storage tank; 4-peristaltic pump; 5-liquid atomizer; 6-buffer tank; 7-cyclone separator; 11-heat source; 12-drying tower A; 13-drying tower B; 14-three-way valve A; 61-sensor; 62-air pump; 63

[0067] - three-way valve B; 71 - cone; 72 - silo; 73 - dust collector. DETAILED DESCRIPTION

[0068] The present invention is further described below in conjunction with specific embodiments.

[0069] Implementation

[0070] The device for adjusting powder and mixing powder comprises a heating dehumidifier 1, a gas heater 2, a liquid storage tank 3, a peristaltic pump 4, a liquid atomizer 5, a buffer tank 6, and a cyclone separator 7; the heating dehumidifier 1, the gas heater 2, the liquid storage tank 3, the peristaltic pump 4, the liquid atomizer 5, the buffer tank 6, and the cyclone separator 7 are sequentially connected through pipelines. The heating dehumidifier 1 is used to reduce the humidity of the compressed gas to below 30%RH. The gas heater 2 is used to heat the gas from the heating dehumidifier 1 to a set temperature; the liquid storage tank 3 is used to store the solution required for atomization by the liquid atomizer 5; the peristaltic pump 4 is used to transport the solution from the liquid storage tank 3 to the liquid atomizer 5; the liquid atomizer 5 is used to atomize the solution from the liquid storage tank 3 and transport it to the buffer tank 6; the buffer tank 6 is used to mix the gas from the gas heater 2 and the liquid atomizer 5; the cyclone separator 7 is used to use the gas from the buffer tank 6 to drive the movement of the material. The heating dehumidifier 1 is used to reduce the humidity of the compressed gas to 10% RH; the heating dehumidifier 1 includes a heat source 11, a drying tower A12, a drying tower B13 and a three-way valve A14, the heat source 11 is used to heat the adsorption filler of the drying tower A12 and the adsorption filler of the drying tower B13 to a preset temperature, and the drying towers A12 and B13 are used to absorb moisture in the gas from the three-way valve A14. The heating method of the heat source 11 is electric heating or microwave heating; the three-way valve A14 is used to control the gas flow to the drying tower A12 or the drying tower B13. The buffer tank 6 is provided with a sensor 61, an air pump 62 and a three-way valve B63. The sensor 61, the air pump 62 and the three-way valve B63 are connected in sequence. The sensor 61 is used to monitor the parameters of the gas from the buffer tank 6 and control the three-way valve B63 leading to the cyclone separator 7 according to the parameters. The air pump 62 is used to control the flow rate and pressure of the gas leading to the cyclone separator 7. The three-way valve B63 is also connected to the buffer tank 6 and the liquid atomizer 5. The cyclone separator 7 includes a cone 71, a silo 72 and a dust collector 73. The dust collector 73 is connected to the cone 71, and the silo 72 is arranged below the cone 71. The cone 71 receives the gas from the three-way valve B63 and circulates in the cavity of the cone 71 to generate centrifugal force to drive the material to move. The silo 72 is used to store materials and receive the centrifugal force of the gas from the cone 71. The dust collector 73 is used to collect the scattered dust from the silo 72.

[0071] Specifically, if Figure 1As shown, the air outlet of the heating dehumidifier 1 is connected to the air inlet of the gas heater 2, the air outlet of the gas heater 2 is connected to the air inlet on the left side of the buffer tank 6, the liquid storage tank 3 is connected to the liquid inlet of the peristaltic pump 4, the liquid outlet of the peristaltic pump 4 is connected to the liquid inlet of the liquid atomizer 5, the outlet of the liquid atomizer 5 is connected to the air inlet above the buffer tank 6, one end of the air outlet of the buffer tank 6 is connected to the pipeline between the liquid atomizer 5 and the buffer tank 6, and the other end is connected to the cyclone separator 7. The heating dehumidifier 1 reduces the moisture in the air by heating the hygroscopic filler and adjusting the pressure. The heating dehumidifier 1 can be heated by electricity or by microwaves according to the different drying fillers. At the same time, the heating dehumidifier 1 is divided into a drying tower A12 and a drying tower B13. When working, only one drying tower works. When the working drying tower absorbs moisture to saturation, the other drying tower takes over the work. The saturated working tower removes moisture in the tower by heating air to achieve regeneration. The gas heater 2 is a nozzle that can adjust the temperature and can heat the passing air to the set parameters. The liquid storage tank 3 is a sealed tank for storing water or solution. The peristaltic pump 4 can transport the liquid in the liquid storage tank 3 to the liquid atomizer 5. The liquid atomizer 5 breaks the liquid into fine droplets by heating, ultrasound and other methods and transports it to the buffer tank 6. The buffer tank 6 is used to mix the dried air and fine droplets. Through the monitoring feedback of sensors such as temperature, humidity, flow, and pressure, the relevant parameters of the passing gas can be known and adjusted. The cyclone separator 7 is used to fully contact the passing gas with the drug powder therein, and at the same time use the centrifugal force generated by the gas to drive the powder to move, so as to adjust the powder properties, eliminate static electricity and mix the materials.

[0072] The experimental process of the above device is as follows:

[0073] Preparation:

[0074] Place the materials to be processed into the silo 72 and the liquid storage tank 3 respectively, and ensure that the equipment is tightly connected to prevent leakage. Check the tightness of the equipment to ensure that the gas and liquid will not leak during the whole process.

[0075] Parameter settings:

[0076] Set the compressed air humidity within the range of 30% RH, and select the appropriate humidity value according to the experimental requirements. Set the inlet pressure between 0 bar and 8 bar to ensure smooth flow of gas in the system. Set the temperature of cyclone separator 7 between 0 ° C and 60 ° C, and select the appropriate temperature according to the properties of the powder.

[0077] Start the device:

[0078] The heating dehumidifier 1 is started to reduce the humidity of the compressed air to a preset value. The gas heater 2 is started to heat the passing gas to a set temperature to ensure that a suitable temperature environment is maintained when the powder is processed in the cyclone separator (7). The liquid atomizer 5 is started to atomize the liquid in the liquid storage tank 3 into fine droplets, ready to be mixed with the gas.

[0079] Adjust the airflow:

[0080] The three-way valve B63 of the buffer tank 6 is opened to the circulation mode, and the air pump 62 is started to adjust the flow rate and pressure of the air flow. The peristaltic pump 4 is started to deliver the liquid in the liquid storage tank to the liquid atomizer at a set flow rate.

[0081] Gas parameter optimization:

[0082] Wait for the gas in the buffer tank 6 to reach the set parameters, including humidity, temperature, flow rate and pressure. After ensuring that the gas parameters reach the optimal state through monitoring by the sensor 61, open the three-way valve B63 of the buffer tank 6 to the path leading to the cyclone separator 7.

[0083] Powder handling / mixing:

[0084] The powder is processed / mixed by the cyclone separator 7, and the centrifugal force generated by the high-speed rotating airflow is used to disperse and mix the powder. Wait for the powder processing or mixing to be completed. End of the experiment:

[0085] Reopen the three-way valve B63 of the buffer tank 6 to the circulation mode to prevent the residual gas and liquid from flowing into the cyclone separator. Turn off the peristaltic pump 4, the air pump 62, the heating dehumidifier 1 and the gas heater 2 in sequence, and stop the operation of all equipment.

[0086] For cleaning and maintenance:

[0087] Thoroughly clean the silo, cyclone separator and dust collector to ensure that there is no residual material. Check and clean all connecting pipes to prevent material blockage. Check the sealing of each component to prevent leakage during the next use. Record the experimental data and observations, and perform data analysis and summary. Through the above optimized experimental process, it can ensure that the equipment achieves the best processing effect during operation, while improving the safety and repeatability of the experiment.

[0088] The main functions of the above disclosed device include:

[0089] Stabilize the properties of powders after micronization: By controlling the temperature, humidity, flow rate and composition of the air flow, the surface shape of the powder can be effectively adjusted.

[0090] Eliminate static electricity: By utilizing the centrifugal force and humidity regulation in the airflow, the high static charge generated during the powder micronization process is successfully eliminated, improving the dispersion and uniformity of the powder.

[0091] Mixing of raw materials and excipients: Through gas drive and the centrifugal force of the cyclone separator, uniform mixing of various powders is achieved, ensuring the uniform distribution of drug raw materials and excipients, and improving product quality and efficacy.

[0092] Application in multiple fields: In addition to the medical field, the device also shows good application prospects in food processing, chemical production, electronic material preparation and other fields involving powder engineering.

[0093] Improved production efficiency: By quickly adjusting powder properties, the device significantly shortens processing time and improves production efficiency.

[0094] Energy saving and environmental protection: By precisely controlling airflow parameters, energy consumption is reduced, embodying the concept of environmental protection.

[0095] Safety and ease of use: Automated control and monitoring systems reduce manual intervention, reduce human errors in the production process, and improve production safety and ease of operation.

[0096] In summary, the present invention provides an efficient and flexible solution to solve a series of challenges currently faced in powder engineering, significantly improves production efficiency and product quality, and expands the scope of application, providing new technical support for the development of related industries.

[0097] Application Solution 1

[0098] Methods for adjusting powder properties:

[0099] Sample preparation

[0100] - Weigh 20 g of crude lactose with a particle size of 300 μm.

[0101] - Use a jet mill to grind the lactose, set the feed pressure to 6 bar, the grinding pressure to 6 bar, and the feed rate to 2 g / min.

[0102] Particle size determination

[0103] -The particle size of lactose powder was measured by laser particle size analyzer and determined to be 4.8 μm.

[0104] - Divide the crushed lactose powder into two equal parts and label them as lactose A and lactose B respectively.

[0105] Equipment preparation

[0106] - Transfer the lactose A into the silo 72 of the device of the present invention, ensuring that the equipment is well sealed to prevent leakage.

[0107] - Fill the liquid storage tank 3 with 2L of deionized water for the subsequent adjustment process.

[0108] Parameter settings

[0109] - Set the humidity of the compressed air to 60% RH.

[0110] -Set the inlet pressure to 4 bar to ensure the flow of gas in the system.

[0111] - The operating temperature of the cyclone separator 7 is set to 45°C to optimize the surface treatment of the powder.

[0112] Experimental run

[0113] - Start the heating dehumidifier 1, the air heater 2 and the liquid atomizer 5, and wait for the equipment to stabilize to the above set parameters.

[0114] -Open the three-way valve B63 of buffer tank 6 to circulation mode, start the air pump and peristaltic pump to ensure smooth flow of air and liquid.

[0115] -After the gas parameters meet the requirements, open the three-way valve B63 of the buffer tank 6 to the cyclone separator and start processing lactose A.

[0116] -After running for 2 hours, the equipment is shut down and lactose A is taken out from silo 72.

[0117] Results Analysis

[0118] - The laser particle size analyzer was used to re-measure lactose A, and it was found that its particle size increased to 4.9 μm, indicating that the device of the present invention has a certain influence on the stability of the powder particle size.

[0119] - Take some lactose A and lactose B samples and conduct stability tests at different time periods (1, 7, 14, 30, 60 days). According to the laser particle size analyzer, the particle size of lactose A sample did not change, while the particle size of lactose B sample increased to 5.1 μm.

[0120] Mixing and Sample Preparation

[0121] - Lactose A and lactose B, which had been stored for one day, were mixed with budesonide powder (X 90 =4.2μm) were mixed and sampled.

[0122] -Through NGI (Next Generation Impactor) testing, it was found that the FPF (Fine Particle Fraction) of the finished product prepared using lactose A was 47%, while the FPF of the finished product prepared using lactose B was 43%.

[0123] Through this experimental process, the device of the present invention can effectively stabilize the particle size of lactose micropowder, reduce the electrostatic effect, and after mixing with the drug, can improve the uniformity of the mixture and the delivery efficiency of the drug.

[0124] Application Solution 2

[0125] Methods for adjusting powder properties:

[0126] Sample preparation

[0127] Weigh 20 g of coarse desonide with a particle size greater than 200 μm.

[0128] Budesonide was crushed using a jet mill, and the feed pressure was set to 6 bar, the crushing pressure was set to 6 bar, and the feed rate was set to 2 g / min.

[0129] Particle size determination and sampling

[0130] The particle size of budesonide micropowder was measured by laser particle size analyzer and was 4.3 μm.

[0131] The crushed budesonide micropowder was divided into two parts, marked as budesonide A and budesonide B, for comparative experiments.

[0132] Equipment preparation

[0133] The budesonide A is transferred into the silo 72 of the device of the present invention, ensuring that the equipment is well sealed to prevent leakage.

[0134] 2 L of ethanol was poured into the liquid storage tank 3 for the subsequent adjustment process.

[0135] Parameter settings

[0136] Set the humidity of the compressed air to 60% RH.

[0137] Set the inlet pressure to 4 bar to ensure the flow of gas in the system.

[0138] The operating temperature of the cyclone separator 7 is set to 45° C. to optimize the surface treatment of the powder.

[0139] Experimental run

[0140] Start the heating dehumidifier 1, the air heater 2 and the liquid atomizer 5, and wait for the equipment to stabilize to the above set parameters.

[0141] Open the three-way valve B63 of the buffer tank 6 to the circulation mode, start the air pump 62 and the peristaltic pump 4, and ensure smooth flow of gas and liquid.

[0142] After the gas parameters reach the set value, the process of treating budesonide A is started.

[0143] After the equipment has been running for 2 hours, the equipment is shut down and budesonide A is taken out from the silo 72 .

[0144] Results Analysis

[0145] The particle size of budesonide A was determined by a laser particle size analyzer and remained unchanged at 4.3 μm, indicating that the device of the present invention has a significant effect on the stability of the powder particle size.

[0146] Some samples of budesonide A and budesonide B were taken for stability testing at different time periods (1, 7, 14, 30, and 60 days). The test found that the particle size of budesonide A did not change, while the particle size of budesonide B increased to 4.6 μm.

[0147] Mixing and Sample Preparation

[0148] Budesonide A and budesonide B that had been stored for 1 day were mixed with Megilide L500 lactose and samples were prepared.

[0149] Through NGI (Next Generation Impactor) detection, it was found that the FPF (Fine Particle Fraction) of the finished product prepared using budesonide A was 48%, while the FPF of the finished product prepared using budesonide B was 45%.

[0150] Through this experimental process, the device of the present invention can effectively stabilize the particle size of budesonide micropowder, reduce the electrostatic effect, and improve the uniformity of the mixture and the delivery efficiency of the drug after mixing with lactose.

[0151] Application Solution 3

[0152] The present invention discloses a method for eliminating static electricity:

[0153] Weigh 20g of coarse budesonide (>200μm) and crush it using a jet mill, with a feed pressure of 6bar, a crushing pressure of 6bar, and a feed rate of 2g / min. The particle size of the budesonide micropowder was measured to be 4.3μm using a laser particle size analyzer. The static electricity of the budesonide micropowder was detected to be 24.12nC / g using an electrometer. The obtained budesonide micropowder was divided into two parts, labeled as budesonide A and budesonide B. Budesonide B was placed in an environment of 20°C and 50%RH. Budesonide A was transferred to the silo 72 of the device of the present invention, and the equipment was checked for integrity of sealing. 2L of water was added to the liquid storage tank 3. The compressed air humidity was set to 60%RH, the air inlet pressure to 4bar, and the cyclone temperature to 45°C. Open the equipment according to the operation, process budesonide A, close the equipment after 0.5 hours, and take out budesonide A. The electrometer detected that budesonide A carried a charge of 3.47 nC / g and budesonide B carried a charge of 8.61 nC / g.

[0154] Application Solution 4

[0155] A method for mixing materials is disclosed:

[0156] Weigh 4g of budesonide (homemade, 4.3μm) and 16g of lactose (Meginyl, L500). Premix in a stainless steel container for 2min. Sieve the premixed material (300um). Add the sieved material into silo 72. Set the compressed air humidity to 55%RH, the inlet pressure to 6bar, and the cyclone temperature to 20°C. Turn on the equipment according to the operation, and take out the sample after mixing for 5min. Repeat the above steps once. The content uniformity of the mixed material was obtained by content detection, and the RSD was 97% and 2.14%.

[0157] The above contents are further detailed descriptions of the present invention in combination with specific implementation methods. It cannot be determined that the specific implementation of the present invention is limited to these descriptions. For ordinary technicians in the field of powder engineering technology to which the present invention belongs, several simple deductions or substitutions can be made without departing from the concept of the present invention, which should be regarded as belonging to the protection scope determined by the claims submitted by the present invention.

Claims

1. A device for adjusting powder and for mixing powder, characterized in that: The device comprises a heating dehumidifier (1), a gas heater (2), a liquid storage tank (3), a peristaltic pump (4), a liquid atomizer (5), a buffer tank (6), and a cyclone separator (7); The heating dehumidifier (1), the gas heater (2), the liquid storage tank (3), the peristaltic pump (4), the liquid atomizer (5), the buffer tank (6), and the cyclone separator (7) are sequentially connected through pipelines; The heating dehumidifier (1) is used to reduce the humidity of the compressed gas to below 30% RH; The gas heater (2) is used to heat the gas from the heating dehumidifier (1) to a set temperature; The liquid storage tank (3) is used to store the solution required for atomization by the liquid atomizer (5); The peristaltic pump (4) is used to transport the solution in the liquid storage tank (3) to the liquid atomizer (5); The liquid atomizer (5) is used to atomize the solution from the liquid storage tank (3) and transport it to the buffer tank (6); The buffer tank (6) is used to mix the gas from the gas heater (2) and the gas from the liquid atomizer (5); The cyclone separator (7) is used to utilize the gas from the buffer tank (6) to drive the movement of the material.

2. The device for adjusting powder and mixing powder according to claim 1, characterized in that: The heating dehumidifier (1) is used to reduce the humidity of the compressed gas to 10% RH; The heating dehumidifier (1) comprises a heat source (11), a drying tower A (12), a drying tower B (13) and a three-way valve A (14), wherein the heat source (11) is used to heat the adsorption filler of the drying tower A (12) and the adsorption filler of the drying tower B (13) to a preset temperature, and the drying tower A (12) and the drying tower B (13) are used to absorb moisture in the gas from the three-way valve A (14).

3. The device for adjusting powder and mixing powder according to claim 2, characterized in that: The heating method of the heat source (11) is electric heating or microwave heating; The three-way valve A (14) is used to control the flow of gas to the drying tower A (12) or the drying tower B (13).

4. The device for adjusting powder and mixing powder according to claim 3, characterized in that: The buffer tank (6) is provided with a sensor (61), an air pump (62) and a three-way valve B (63). The sensor (61), the air pump (62) and the three-way valve B (63) are connected in sequence. The sensor (61) is used to monitor the parameters of the gas from the buffer tank (6) and control the three-way valve B (63) leading to the cyclone separator (7) according to the parameters. The air pump (62) is used to control the flow rate and pressure of the gas leading to the cyclone separator (7).

5. The device for adjusting powder and mixing powder according to claim 4, characterized in that: The three-way valve B (63) is also connected to the buffer tank (6) and the liquid atomizer (5).

6. The device for adjusting powder and mixing powder according to claim 5, characterized in that: The cyclone separator (7) comprises a cone (71), a silo (72) and a dust collector (73); the dust collector (73) is connected to the cone (71), and the silo (72) is arranged below the cone (71).

7. The device for adjusting powder and mixing powder according to claim 6, characterized in that: The cone (71) receives gas from the three-way valve B (63) and circulates the gas in the cavity of the cone (71) to generate centrifugal force to drive the material to move.

8. The device for adjusting powder and mixing powder according to claim 7, characterized in that: The silo (72) is used to store materials and receive the centrifugal force of the gas from the cone (71).

9. The device for adjusting powder and mixing powder according to claim 8, characterized in that: The dust collector (73) is used to collect the scattered dust from the silo (72).

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