Continuous series separation system and flow path control method thereof

Abstract

The invention relates to the technical field of separation systems, in particular to a continuous series separation system and a flow path control method thereof.The continuous series separation system comprises an inlet valve, an infusion pump, a column position valve, a series separation module and an outlet valve which are sequentially connected in series; the inlet valve and the column position valve are each provided with a main connecting hole, a communicating groove and a branch connecting hole module, the main connecting holes are communicated with the branch connecting hole modules through the communicating grooves, the outlet valve is provided with a valve hole module, and a valve element of the outlet valve is further provided with a valve groove module used for enabling the interior of the valve hole module to be controllably communicated. According to the invention, the continuity of the separation and purification process of the product is improved, so that the separation and purification efficiency of the product is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of separation systems, and in particular to a continuous series separation system and a flow path control method thereof. Background Art

[0002] In the pharmaceutical, chemical and other industries, separation and purification of products is an essential part of product research. With the increasing demand in the international and domestic markets, the requirements for product purity are gradually increasing, which makes the requirements for separation systems higher and higher.

[0003] Most existing separation systems use the differences in the affinity of various substances in the product to be separated, such as the distribution coefficient and adsorption capacity, between the two phases to separate them, thereby improving the purity of the product. The separation methods used in existing separation systems are often relatively simple, with problems such as low separation efficiency, narrow scope of application, and inability to meet the requirements for separation of complex mixtures.

[0004] At present, when separating and purifying products with complex mixtures, a single separation system is unable to effectively separate and purify the products, resulting in difficulty in achieving the required purity standard for the products. Therefore, it is necessary to separate and purify the products multiple times through multiple separation systems in order to achieve the required purity standard for the products, resulting in intermittent separation and purification processes for existing products, which in turn leads to low efficiency in the separation and purification processes for the products. Summary of the invention

[0005] In order to improve the continuity of the product separation and purification process, thereby improving the separation and purification efficiency of the product, the present application provides a continuous series separation system and a flow path control method thereof.

[0006] The present application provides a continuous series separation system and a flow path control method thereof, which adopts the following technical solutions: A continuous series separation system comprises an inlet valve, an infusion pump, a column position valve, a series separation module and an outlet valve which are arranged in sequence, the infusion pump is connected to the inlet valve, the column position valve is connected to the infusion pump, the series separation module is connected to the column position valve, the outlet valve is connected to the series separation module, and the outlet valve is connected to the inlet valve, the inlet valve and the column position valve are both provided with a main connection hole, a connecting groove and a branch hole module, and the main connection hole is connected to the branch hole module through the connecting groove, the outlet valve is provided with a valve hole module, and the valve core of the outlet valve is also provided with a valve groove module for making the valve hole module controllably connected.

[0007] By adopting the above technical solution, the use of series separation modules helps to achieve continuous sampling and internal series circulation flow of products, thereby helping to improve the continuity of multiple separation and purification of products, and further helping to improve the separation and purification efficiency of products.

[0008] In a specific possible implementation scheme, the series separation module includes a separation column 1, a separation column 2, a separation column 3, a three-way one-way valve 1 and a three-way one-way valve 2, one end of the separation column 1 is connected to the column position valve, the other end of the separation column is connected to the three-way one-way valve 1, one end of the separation column 2 is connected to the outlet valve, the other end of the separation column 2 is connected to the three-way one-way valve 1, and the three-way one-way valve 1 is connected to the column position valve, one end of the separation column 3 is connected to the outlet valve, the other end of the separation column 3 is connected to the three-way one-way valve 2, and the column position valve and the outlet valve are both connected to the three-way one-way valve 2.

[0009] By adopting the above technical solution, the use of the separation column 1, the separation column 2 and the separation column 3 connected in series helps to realize the series circulation flow of the product inside the separation system, thereby helping to improve the continuity of multiple separation and purification of the product, and further helping to improve the separation and purification efficiency of the product. The use of the three-way one-way valve 1 and the three-way one-way valve 2 helps to adjust the series circulation flow path of the product inside the separation system, thereby helping to improve the continuity of multiple separation and purification of the product, and further helping to improve the separation and purification efficiency of the product.

[0010] In a specific feasible implementation scheme, the branch hole module includes branch hole 1, branch hole 2, branch hole 3, branch hole 4, branch hole 5, branch hole 6, branch hole 7 and branch hole 8, the outlet valve is connected to the branch hole 7 on the inlet valve, the infusion pump is connected to the main connection hole on the column position valve, the separation column 1 is connected to the branch hole 1 on the column position valve, the three-way one-way valve 1 is connected to the branch hole 2 on the column position valve, and the three-way one-way valve 2 is connected to the branch hole 3 on the column position valve.

[0011] By adopting the above technical solution, the use of branch hole modules helps to improve the continuity of product circulation flow, thereby helping to further improve the separation and purification efficiency of the product.

[0012] In a specific feasible implementation scheme, the inlet valve and the column position valve are both arranged in a disc shape, the main connecting holes on the inlet valve and the column position valve are both arranged at the center position, and the distances between the branch hole one, branch hole two, branch hole three, branch hole four, branch hole five, branch hole six, branch hole seven, and branch hole eight and the main connecting hole are equal.

[0013] In a specific feasible implementation scheme, the valve hole module includes valve hole one, valve hole two, valve hole three, valve hole four, valve hole five, valve hole six and valve hole seven, and the valve hole seven is connected to the series separation module, the separation column two is connected to the valve hole seven, the separation column three is connected to the valve hole four, the three-way one-way valve two is connected to the valve hole five, and the valve hole two is connected to the branch hole seven on the inlet valve; the valve slot module includes a first valve slot, a second valve slot and a third valve slot arranged on the valve core of the outlet valve, and the valve holes one, valve holes two, valve holes three, valve holes four, valve holes five, valve holes six and valve holes seven are controllably connected in pairs through the first valve slot, the second valve slot and the third valve slot.

[0014] By adopting the above technical solution, using the valve hole module in conjunction with the valve slot module helps to improve the continuity of the product circulation flow, thereby helping to further improve the separation and purification efficiency of the product.

[0015] In a specific feasible implementation scheme, the valve hole seven is arranged at the center position of the outlet valve, and the valve holes one, two, three, four, five and six are arranged in a circular array along the central axis of the outlet valve.

[0016] In a specific implementation scheme, a three-way buffer valve is arranged between the inlet valve and the infusion pump, the liquid inlet of the three-way buffer valve is connected to the main connection hole on the inlet valve, and the liquid outlet of the three-way buffer valve is connected to the infusion pump.

[0017] By adopting the above technical solution, the three-way buffer valve is used to help reduce the flow rate and pressure of the product in the pipeline, thereby helping to improve the stability and safety of the separation system.

[0018] A flow path control method based on the above continuous series separation system comprises the following steps: Step 1: Start the infusion pump to allow the eluent 1 to enter from the inlet valve. Under the action of the infusion pump, the eluent 1 flows through the column valve and the series separation module in sequence, and then flows into the outlet valve; Step 2: Adjust the internal flow path of the outlet valve so that the outlet valve and the inlet valve are connected, so that the eluent flows from the outlet valve to the inlet valve, and then flows through the column valve and the series separation module again and then flows into the outlet valve, circulating; Step 3: Stop the circulation of eluent 1, so that eluent 1 enters from the inlet valve, and under the action of the infusion pump, eluent 1 flows through the column valve and the series separation module in sequence, so that the waste liquid flows out from the outlet valve; Step 4: allow the eluent 2 to enter from the inlet valve, and under the action of the infusion pump, allow the eluent 2 to flow through the column valve, the series separation module, the outlet valve and the series separation module in sequence, and then flow into the outlet valve again; Step 5: Adjust the internal flow path of the outlet valve so that the outlet valve and the inlet valve are connected, so that the eluent 2 flows from the outlet valve into the inlet valve and circulates along the flow path; Step 6: Stop the circulation of eluent 2, allow eluent 2 to enter from the inlet valve, and under the action of the infusion pump, allow eluent 2 to flow through the column valve and the series separation module in sequence, so that the product liquid flows out from the outlet valve and is collected.

[0019] By adopting the above technical solution, the series circulation flow of the product within the separation system is utilized to help separate and purify the product multiple times, thereby helping to improve the continuity of multiple separation and purification of the product, and further helping to improve the separation and purification efficiency of the product.

[0020] In a specific implementation scheme, in step one, eluent one flows through the column position valve, separation column one, separation column two and outlet valve in sequence; in step three, eluent one flows through the column position valve, separation column two and outlet valve in sequence; in step four, eluent two flows through the column position valve, separation column two, outlet valve, separation column three and outlet valve in sequence; in step six, eluent two flows through the column position valve, separation column three and outlet valve in sequence.

[0021] By adopting the above technical solution, using multiple flow paths of eluent one and eluent two helps to improve the separation and purification effect of the product.

[0022] In a specific implementation scheme, after step six is ​​completed, there are also the following steps: Step 7: allow the eluent 3 to enter from the inlet valve, and under the action of the infusion pump, allow the eluent 3 to flow through the column valve and the separation column 3 in sequence to flush the separation column 3, so that the waste liquid flows out from the outlet valve, and the waste liquid is collected; Step 8: allow the eluent 2 to enter from the inlet valve, and under the action of the infusion pump, allow the eluent 2 to flow through the column position valve and the separation column 3 in sequence, flush the separation column 3, allow the waste liquid to flow out from the outlet valve, and collect the waste liquid; Step nine: allow eluent 1 to enter from the inlet valve, and under the action of the infusion pump, allow eluent 1 to flow through the column valve and separation column 2 in sequence to flush the separation column 2, allow waste liquid to flow out from the outlet valve, and collect the waste liquid.

[0023] By adopting the above technical solution, the flow of eluent three, eluent two and eluent one inside the separation system helps to flush separation column three and separation column two, thereby facilitating the next separation and purification of the product.

[0024] In summary, the present application includes at least one of the following beneficial technical effects: 1. This application uses the setting of series separation modules, which helps to achieve continuous sampling and internal series circulation flow of products, thereby helping to improve the continuity of multiple separation and purification of products, and further helping to improve the separation and purification efficiency of products.

[0025] 2. This application uses a three-way buffer valve, which helps to reduce the flow rate and pressure of the product in the pipeline, thereby helping to improve the stability and safety of the separation system. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 It is a schematic diagram of the overall structure of an embodiment of the present application.

[0027] Figure 2 It is a flow path schematic diagram of step one in the embodiment of the present application.

[0028] Figure 3 It is a schematic diagram of the flow path of step 2 in the embodiment of the present application.

[0029] Figure 4 It is a schematic diagram of the flow path of step three in the embodiment of the present application.

[0030] Figure 5 It is a schematic diagram of the flow path of step four in the embodiment of the present application.

[0031] Figure 6 It is a schematic diagram of the flow path of step five in the embodiment of the present application.

[0032] Figure 7 It is a flow path schematic diagram of step six in the embodiment of the present application.

[0033] Figure 8 It is a flow path schematic diagram of step seven in the embodiment of the present application.

[0034] Fig. 9 It is a flow path schematic diagram of step eight in the embodiment of the present application.

[0035] Fig.10 It is a flow path schematic diagram of step nine in the embodiment of the present application.

[0036] Explanation of the accompanying drawings: 1. Inlet valve; 2. Infusion pump; 3. Column position valve; 4. Series separation module; 41. Separation column one; 42. Separation column two; 43. Separation column three; 44. Three-way one-way valve one; 45. Three-way one-way valve two; 5. Outlet valve; 6. Main connecting hole; 7. Branch hole module; 71. Branch hole one; 72. Branch hole two; 73. Branch hole three; 74. Branch hole four; 75. Branch hole five; 76. Branch hole six; 77. Branch hole seven; 78. Branch hole eight; 8. Valve hole module; 81. Valve hole one; 82. Valve hole two; 83. Valve hole three; 84. Valve hole four; 85. Valve hole five; 86. Valve hole six; 87. Valve hole seven; 9. Three-way buffer valve; 10. Connecting groove; 11. First valve groove; 12. Second valve groove; 13. Third valve groove. DETAILED DESCRIPTION

[0037] The present application is further described in detail below in conjunction with the accompanying drawings.

[0038] The present application discloses a continuous series separation system and a flow path control method thereof, referring to Figure 1 , including an inlet valve 1, a three-way buffer valve 9, an infusion pump 2, a column position valve 3, a series separation module 4 and an outlet valve 5 which are fixedly installed in sequence, the liquid inlet of the three-way buffer valve 9 is connected to the inlet valve 1 through a pipeline, the infusion pump 2 is connected to the liquid outlet of the three-way buffer valve 9 through a pipeline, the column position valve 3 is connected to the infusion pump 2 through a pipeline, the series separation module 4 is connected to the column position valve 3 through a pipeline, the outlet valve 5 is connected to the series separation module 4 through a pipeline, and the outlet valve 5 is connected to the inlet valve 1 through a pipeline.

[0039] Reference Figure 1 A connecting groove 10 is provided on the internal valve cores of the inlet valve 1 and the column valve 3. A valve hole module is provided on the internal valve core of the outlet valve 5, and the valve hole module includes a first valve groove 11, a second valve groove 12 and a third valve groove 13. The first valve groove 11, the second valve groove 12 and the third valve groove 13 are all provided on the valve core of the outlet valve 5 and are not connected to each other.

[0040] Reference Figure 1 The inlet valve 1 and the column valve 3 are both disc-shaped, and the center positions of the inlet valve 1 and the column valve 3 are both provided with a main connection hole 6. The liquid inlet of the three-way buffer valve 9 is connected with the main connection hole 6 of the inlet valve 1, and the infusion pump 2 is connected with the main interface of the column valve 3. The inlet valve 1 and the column valve 3 are also provided with a branch hole module 7, which includes a branch hole 1 71, a branch hole 2 72, a branch hole 3 73, a branch hole 4 74, a branch hole 5 75, a branch hole 6 76, a branch hole 77 and a branch hole 8 78, which are equidistant from the main interface. The main connection hole 6 is controllably connected with one of the branch hole 1 71, the branch hole 2 72 and the branch hole 3 73 through the connecting groove 10.

[0041] Reference Figure 1The outlet valve 5 is disc-shaped, and a valve hole module 8 is arranged on the outlet valve 5. The valve hole module 8 includes valve hole 1 81, valve hole 2 82, valve hole 3 83, valve hole 4 84, valve hole 5 85, valve hole 6 86 and valve hole 7 87. Valve hole 7 87 is located at the center of the outlet valve 5, and the valve holes 1 81, valve hole 2 82, valve hole 3 83, valve hole 4 84, valve hole 5 85 and valve hole 6 86 are arranged in a circular array along the central axis of the outlet valve 5, and the valve holes 1 81, valve hole 2 82, valve hole 3 83, valve hole 4 84, valve hole 5 85, valve hole 6 86 and valve hole 7 87 are controllably connected in pairs through the first valve slot 11, the second valve slot 12 and the third valve slot 13. The valve hole 2 82 on the outlet valve 5 is connected to the branch hole 77 on the inlet valve 1 through a pipeline, and the branch hole 77 on the inlet valve 1 is controllably connected to the main connection hole 6 on the inlet valve 1 .

[0042] Reference Figure 1 The series separation module 4 includes a separation column 1 41, a separation column 2 42, a separation column 3 43, a three-way one-way valve 1 44 and a three-way one-way valve 2 45. One end of the separation column 1 41 is connected to the branch hole 1 71 on the column position valve 3 through a pipeline, and the other end of the separation column is connected to the three-way one-way valve 1 44 through a pipeline. One end of the separation column 2 42 is connected to the valve hole 7 87 on the outlet valve 5 through a pipeline, and the other end of the separation column 2 42 is connected to the three-way one-way valve 1 44 through a pipeline, and the three-way one-way valve 1 44 is connected to the branch hole 2 72 on the column position valve 3 through a pipeline, one end of the separation column 3 43 is connected to the valve hole 4 84 on the outlet valve 5 through a pipeline, and the other end of the separation column 3 43 is connected to the three-way one-way valve 2 45 through a pipeline, and the branch hole 3 73 on the column position valve 3 and the valve hole 5 85 on the outlet valve 5 are both connected to the three-way one-way valve 2 45 through a pipeline. The separation column 1 41, the separation column 2 42 and the separation column 3 43 connected in series help to achieve the series circulation flow of the product within the separation system, thereby helping to improve the continuity of multiple separation and purification of the product, and further helping to improve the separation and purification efficiency of the product.

[0043] The present application also discloses a flow path control method for the above-mentioned continuous series separation system, comprising the following steps: Reference Figure 2 Step 1: Make the branch hole 1 71 on the inlet valve 1 and the main connection hole 6 connected through the connecting groove 10, start the infusion pump 2, so that the eluent 1 enters from the branch hole 1 71 of the inlet valve 1 and then flows out from the main connection hole 6 of the inlet valve 1. Under the action of the infusion pump 2, the eluent 1 flows through the column position valve 3, the separation column 1 41 and the separation column 2 42 in sequence, and then flows into the outlet valve 5 from the valve hole 7 87. Make the valve hole 7 87 and the valve hole 6 86 connected through the second valve groove 12, so that the excess eluent 1 is discharged through the valve hole 6 86.

[0044] Reference Figure 3, step 2: adjust the internal flow path of the outlet valve 5 so that the valve hole 7 87 is connected with the valve hole 2 82 through the second valve slot 12, so that the eluent 1 flows into the inlet valve 1 through the valve hole 2 82 and the branch hole 77 on the inlet valve 1 in sequence, and at the same time, the branch hole 77 on the inlet valve 1 and the main connection hole 6 are connected through the connecting slot 10, and the eluent 1 flows into the outlet valve 5 again along the flow path in step 1, and circulates.

[0045] Reference Figure 4 , step three: stop the circulation of the eluent one, make the branch hole one 71 on the inlet valve 1 and the main connection hole 6 connected through the connecting groove 10, so that the new eluent one enters from the branch hole one 71 of the inlet valve 1 and flows out from the main connection hole 6 of the inlet valve 1, and under the action of the infusion pump 2, the eluent flows through the column position valve 3 and the separation column two 42 in sequence, and at the same time, the valve hole seven 87 and the valve hole six 86 are connected through the second valve groove 12, so that the waste liquid flows out from the valve hole six 86 of the outlet valve 5.

[0046] Reference Figure 5 , step four: connect the branch hole 2 72 on the inlet valve 1 with the main connection hole 6 through the connecting groove 10, start the infusion pump 2, so that the eluent 2 enters from the branch hole 2 72 of the inlet valve 1 and then flows out from the main connection hole 6 of the inlet valve 1, and under the action of the infusion pump 2, the eluent 2 flows through the column position valve 3 and the separation column 2 42 in sequence, and adjusts the internal flow path of the outlet valve 5 so that the valve hole 7 87 is connected with the valve hole 5 85 through the second valve groove 12, so that the eluent 2 flows into the outlet valve 5 through the valve hole 7 87 and then flows into the separation column 3 43 through the valve hole 5 85, and then flows into the outlet valve 5 again through the valve hole 5 85, and at the same time, the valve hole 5 85 and the valve hole 6 86 are connected through the third valve groove 13, so that the excess eluent 2 is discharged through the valve hole 6 86.

[0047] Reference Figure 6 , step five: adjust the internal flow path of the outlet valve 5 so that the valve hole seven 87 and the valve hole five 85 are connected through the second valve slot 12, and the valve hole four 84 and the valve hole two 82 are connected through the first valve slot 11, so that the eluent two flows into the outlet valve 5 through the valve hole seven 87 and then flows into the separation column three 43 through the valve hole five 85, and then flows into the outlet valve 5 again through the valve hole four 84, and then flows into the inlet valve 1 through the valve hole two 82 and the branch hole seven 77 on the inlet valve 1 in turn, and at the same time, the branch hole seven 77 on the inlet valve 1 and the main connecting hole 6 are connected through the connecting slot 10, and the eluent two flows into the outlet valve 5 again along the flow path in step four, and circulates.

[0048] Reference Figure 7Step six: stop the circulation of the eluent 2, make the branch hole 2 72 on the inlet valve 1 and the main connection hole 6 connected through the connecting groove 10, start the infusion pump 2, make the new eluent 2 enter from the branch hole 2 72 of the inlet valve 1, and under the action of the infusion pump 2, make the eluent 2 flow through the column position valve 3 and the separation column 3 43 in sequence, and at the same time make the valve hole 4 84 and the valve hole 3 83 connected through the third valve groove 13, so that the product liquid flows out from the valve hole 3 83 of the outlet valve 5, and the product liquid is collected.

[0049] Reference Figure 8 Step seven: connect the branch hole three 73 on the inlet valve 1 with the main connection hole 6 through the connecting groove 10, start the infusion pump 2, so that the eluent three enters from the branch hole three 73 of the inlet valve 1 and then flows out from the main connection hole 6 of the inlet valve 1, and under the action of the infusion pump 2, the eluent three flows through the column position valve 3 and the separation column three 43 in sequence to flush the separation column three 43, and connect the valve hole four 84 and the valve hole six 86 through the first valve groove 11, so that the waste liquid flows from the valve hole four 84 into the outlet valve 5 and flows out from the valve hole six 86, and the waste liquid is collected.

[0050] Reference Fig. 9 Step eight: connect the branch hole 2 72 and the main connection hole 6 on the inlet valve 1 through the connecting groove 10, so that the eluent 2 enters from the branch hole 2 72 of the inlet valve 1 and then flows out from the main connection hole 6 of the inlet valve 1. Under the action of the infusion pump 2, the eluent 2 flows through the column position valve 3 and the separation column 3 43 in sequence to flush the separation column 3 43, and connect the valve hole 4 84 and the valve hole 6 86 through the first valve groove 11, so that the waste liquid flows from the valve hole 4 84 into the outlet valve 5 and flows out from the valve hole 6 86, and the waste liquid is collected.

[0051] Reference Fig.10 Step nine: Make the branch hole 71 on the inlet valve 1 and the main connection hole 6 connected through the connecting groove 10, so that the eluent 1 enters from the branch hole 71 of the inlet valve 1 and then flows out from the main connection hole 6 of the inlet valve 1, and under the action of the infusion pump 2, the eluent 1 flows through the column position valve 3 and the separation column 2 42 in sequence to flush the separation column 2 42, and the valve hole 7 87 and the valve hole 6 86 are connected through the second valve groove 12, so that the waste liquid flows from the valve hole 7 87 into the outlet valve 5 and flows out from the valve hole 6 86, and the waste liquid is collected.

[0052] The above are all preferred embodiments of the present application, and the protection scope of the present application is not limited thereto. Therefore, any equivalent changes made according to the structure, shape, and principle of the present application should be included in the protection scope of the present application.

Claims

1. A continuous series separation system, characterized in that: The invention comprises an inlet valve (1), an infusion pump (2), a column position valve (3), a series separation module (4) and an outlet valve (5) which are connected in series in sequence, wherein the outlet valve (5) is connected to the inlet valve (1), and the inlet valve (1) and the column position valve (3) are both provided with a main connection hole (6), a connecting groove (10) and a branch connection hole module (7), and the main connection hole (6) is connected to the branch connection hole module (7) through the connecting groove (10), the outlet valve (5) is provided with a valve hole module (8), and the valve core of the outlet valve (5) is also provided with a valve groove module for making the valve hole module (8) internally controllably connected.

2. A continuous series separation system according to claim 1, characterized in that: The series separation module (4) comprises a separation column 1 (41), a separation column 2 (42), a separation column 3 (43), a three-way one-way valve 1 (44) and a three-way one-way valve 2 (45); one end of the separation column 1 (41) is connected to the column position valve (3), and the other end of the separation column is connected to the three-way one-way valve 1 (44); one end of the separation column 2 (42) is connected to the outlet valve (5), and the other end of the separation column 2 (42) is connected to the three-way one-way valve 1 (44), and the three-way one-way valve 1 (44) is connected to the column position valve (3); one end of the separation column 3 (43) is connected to the outlet valve (5), and the other end of the separation column 3 (43) is connected to the three-way one-way valve 2 (45), and the column position valve (3) and the outlet valve (5) are both connected to the three-way one-way valve 2 (45).

3. A continuous series separation system according to claim 2, characterized in that: The branch hole module (7) comprises a branch hole 1 (71), a branch hole 2 (72), a branch hole 3 (73), a branch hole 4 (74), a branch hole 5 (75), a branch hole 6 (76), a branch hole 7 (77) and a branch hole 8 (78); the outlet valve (5) is connected to the branch hole 7 (77) on the inlet valve (1); the infusion pump (2) is connected to the main connection hole (6) on the column position valve (3); the separation column 1 (41) is connected to the branch hole 1 (71) on the column position valve (3); the three-way one-way valve 1 (44) is connected to the branch hole 2 (72) on the column position valve (3); and the three-way one-way valve 2 (45) is connected to the branch hole 3 (73) on the column position valve (3).

4. A continuous series separation system according to claim 3, characterized in that: The inlet valve (1) and the column position valve (3) are both arranged in a disc shape, the main connection holes (6) on the inlet valve (1) and the column position valve (3) are both arranged at the center position, and the branch hole 1 (71), branch hole 2 (72), branch hole 3 (73), branch hole 4 (74), branch hole 5 (75), branch hole 6 (76), branch hole 7 (77), branch hole 8 (78) are equidistant from the main connection hole (6).

5. A continuous series separation system according to claim 3, characterized in that: The valve hole module (8) comprises valve hole one (81), valve hole two (82), valve hole three (83), valve hole four (84), valve hole five (85), valve hole six (86) and valve hole seven (87), and the valve hole seven (87) is connected to the series separation module (4), the separation column two (42) is connected to the valve hole seven (87), the separation column three (43) is connected to the valve hole four (84), the three-way one-way valve two (45) is connected to the valve hole five (85), the valve hole two ( 82) is connected to the branch hole seven (77) on the inlet valve (1); the valve slot module includes a first valve slot (11), a second valve slot (12) and a third valve slot (13) arranged on the valve core of the outlet valve (5), and the valve hole one (81), valve hole two (82), valve hole three (83), valve hole four (84), valve hole five (85), valve hole six (86) and valve hole seven (87) are controllably connected in pairs through the first valve slot (11), the second valve slot (12) and the third valve slot (13).

6. A continuous series separation system according to claim 5, characterized in that: The valve hole seven (87) is arranged at the center position of the outlet valve (5), and the valve hole one (81), valve hole two (82), valve hole three (83), valve hole four (84), valve hole five (85) and valve hole six (86) are arranged in a circular array along the central axis of the outlet valve (5).

7. A continuous series separation system according to claim 1, characterized in that: A three-way buffer valve (9) is provided between the inlet valve (1) and the infusion pump (2); the liquid inlet of the three-way buffer valve (9) is communicated with the main connection hole (6) on the inlet valve (1), and the liquid outlet of the three-way buffer valve (9) is communicated with the infusion pump (2).

8. A flow path control method, applied to the continuous series separation system according to any one of claims 1 to 7, characterized in that: The steps include: Step 1: Start the infusion pump (2) to allow eluent 1 to enter from the inlet valve (1). Under the action of the infusion pump (2), the eluent 1 flows through the column valve (3) and the series separation module (4) in sequence, and then flows into the outlet valve (5); Step 2: Adjust the internal flow path of the outlet valve (5) so that the outlet valve (5) and the inlet valve (1) are connected, so that the eluent flows from the outlet valve (5) into the inlet valve (1), and then flows through the column valve (3) and the series separation module (4) again before flowing into the outlet valve (5), thereby circulating; Step 3: Stop the circulation of eluent 1, so that eluent 1 enters from the inlet valve (1), and under the action of the infusion pump (2), the eluent 1 flows through the column valve (3) and the series separation module (4) in sequence, so that the waste liquid flows out from the outlet valve (5); Step 4: allow the second eluent to enter from the inlet valve (1), and under the action of the infusion pump (2), allow the second eluent to flow through the column valve (3), the series separation module (4), the outlet valve (5) and the series separation module (4) in sequence, and then flow into the outlet valve (5) again; Step 5: Adjust the internal flow path of the outlet valve (5) so that the outlet valve (5) and the inlet valve (1) are connected, so that the second eluent flows from the outlet valve (5) into the inlet valve (1) and circulates along the flow path; Step 6: Stop the circulation of the eluent 2, so that the eluent 2 enters from the inlet valve (1), and under the action of the infusion pump (2), the eluent 2 flows through the column valve (3) and the series separation module (4) in sequence, so that the product liquid flows out from the outlet valve (5), and the product liquid is collected.

9. A flow path control method according to claim 8, characterized in that: In step one, the eluent one flows through the column position valve (3), the separation column one (41), the separation column two (42) and the outlet valve (5) in sequence; in step three, the eluent one flows through the column position valve (3), the separation column two (42) and the outlet valve (5) in sequence; in step four, the eluent two flows through the column position valve (3), the separation column two (42), the outlet valve (5), the separation column three (43) and the outlet valve (5) in sequence; in step six, the eluent two flows through the column position valve (3), the separation column three (43) and the outlet valve (5) in sequence.

10. A flow path control method according to claim 8, characterized in that: After step six is ​​completed, there are still the following steps: Step 7: allow the eluent 3 to enter from the inlet valve (1), and under the action of the infusion pump (2), allow the eluent 3 to flow through the column valve (3) and the separation column 3 (43) in sequence, flush the separation column 3 (43), allow the waste liquid to flow out from the outlet valve (5), and collect the waste liquid; Step 8: Allow the eluent 2 to enter from the inlet valve (1), and under the action of the infusion pump (2), allow the eluent 2 to flow through the column valve (3) and the separation column 3 (43) in sequence, flush the separation column 3 (43), allow the waste liquid to flow out from the outlet valve (5), and collect the waste liquid; Step nine: allow the eluent 1 to enter from the inlet valve (1), and under the action of the infusion pump (2), allow the eluent 1 to flow through the column valve (3) and the separation column 2 (42) in sequence, flush the separation column 2 (42), allow the waste liquid to flow out from the outlet valve (5), and collect the waste liquid.

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