Cardiovascular disease detection device

By designing a cardiovascular disease detection device, using clamping components and cylinder control system, the problem of poor time addition of amplification reagents is solved, and the detection accuracy and efficiency are improved.

CN119709387AInactive Publication Date: 2025-03-28南昌大学第一附属医院
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Patent Information

Application Number
CN202411925115.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-25
Publication Date
2025-03-28
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

In cardiovascular disease detection, the prior art has a time difference when adding amplification reagents to the extracted nucleic acid, resulting in detection deviations, and the efficiency of adding amplification reagents is low, which is not conducive to subsequent detection.

Method used

A cardiovascular disease detection device is designed to fix the test tube by clamping the assembly to ensure its verticality, and control the vertical movement of the injection assembly through the second cylinder to realize the delivery of the amplification reagent to multiple test tubes at the same time to avoid time difference.

Benefits of technology

Through this device, the accuracy of detection is improved, detection deviation is reduced, and the efficiency of amplification reagent addition is improved.

✦ Generated by Eureka AI based on patent content.

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Abstract

The invention discloses a cardiovascular disease detection device which comprises a workbench and a containing assembly slidably connected to the top face of the workbench, the containing assembly is controlled by a first air cylinder installed on the workbench to move longitudinally, an injection assembly is arranged above the containing assembly, and the two ends of the injection assembly are slidably connected to a supporting frame. The supporting frame is fixed to the workbench, and the injection assembly is controlled by a second air cylinder installed on the supporting frame to move vertically. The test tubes are firmly fixed in the placement groove through the clamping assembly, the perpendicularity of the test tubes is guaranteed, subsequent injection of amplification reagents is facilitated, the injection set is controlled to ascend and descend through the second air cylinder, the amplification reagents are conveyed into the multiple test tubes at the same time through the injection assembly, time difference existing in addition of the amplification reagents is prevented, and the detection accuracy is improved.
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Description

Technical Field

[0001] The present invention relates to the field of medical device technology, and in particular to a cardiovascular disease detection device. Background Art

[0002] In recent years, the incidence of cardiovascular diseases has become younger and younger, and the treatment options for cardiovascular diseases are very limited. There may be a variety of sequelae after treatment, which seriously affect the quality of life of patients.

[0003] For cardiovascular diseases, miRNA molecules can be released in the relevant tissue cells of patients. Therefore, when diagnosing cardiovascular diseases, miRNA molecules can be used as markers for diagnosis, thereby achieving the effect of early and accurate diagnosis of the disease.

[0004] For example, the patent application number: CN202210782808.4 discloses a detection system for mi RNA markers for the diagnosis of cardiovascular diseases. The application uses a light source to emit a laser of a specific wavelength into the reaction chamber. The laser can penetrate the transparent cover and shine into the reaction chamber to excite the fluorescent groups in the amplification reagent. The generated fluorescence can be obtained by the photoelectric detection module through the transparent cover, thereby obtaining the corresponding fluorescence amplification data and achieving the effect of marker detection.

[0005] For example, the patent with application number: CN202011155376.1 discloses an immunoquantitative detection device, detection method and use of cardiovascular disease markers. The immunoquantitative detection device and detection method of cardiovascular disease markers of this invention are of great significance and good application prospects for improving the existing immunodetection technology of cardiovascular disease markers.

[0006] However, when adding amplification reagents to the extracted nucleic acids, it is often necessary to add the extracted nucleic acids one by one. Thus, when the extracted nucleic acids are tested, detection deviations are likely to occur due to the time difference in the reaction, and the efficiency of adding amplification reagents is low, which is not conducive to subsequent testing. Summary of the invention

[0007] The purpose of the present invention is to provide a cardiovascular disease detection device to solve the above-mentioned problems.

[0008] In order to solve the above technical problems, the present invention adopts the following technical solutions:

[0009] The present invention provides a cardiovascular disease detection device, comprising a workbench and a holding component slidably connected to the top surface of the workbench, wherein the holding component is controlled to move longitudinally by a first cylinder installed on the workbench, an injection component is arranged above the holding component, and both ends of the injection component are slidably connected to a support frame, wherein the support frame is fixed to the workbench, and the injection component is controlled to move vertically by a second cylinder installed on the support frame;

[0010] The containing assembly comprises a hollow containing plate, the piston end of the first cylinder is connected to the containing plate, a plurality of placing grooves are arranged on the top surface of the containing plate, the bottom of the placing grooves is a spherical bottom, a groove is arranged at the front end of the placing grooves, and a clamping assembly is arranged in the placing grooves and the grooves;

[0011] The injection assembly includes a lifting plate and a liquid tank connected to the rear end surface of the lifting plate, the two ends of the lifting plate are slidably connected to the support frame, the top surface of the lifting plate is connected to the piston end of the second cylinder, the front end surface of the lifting plate is connected with pumps corresponding to the placement grooves, the liquid outlet end of the pump is connected to a syringe pointing vertically downward, the liquid inlet end of the pump is connected to a liquid inlet pipe, the other end of the liquid inlet pipe passes through the lifting plate and is connected to a liquid dispensing pipe, and the liquid dispensing pipe is connected to the liquid tank.

[0012] Furthermore, a protective component is provided on the outer side of the support frame, and the protective component includes a protective cover 1 fixed on the workbench and a protective cover 2 hinged on the protective cover 1. The protective cover 1 and the protective cover 2 form a complete protective cover buckled on the workbench.

[0013] Furthermore, the protective cover 2 is provided with an observation window.

[0014] Furthermore, a handle is connected to the front end surface of the second protective cover.

[0015] Furthermore, a first sliding block is connected to the bottom surface of the containing plate, a slide rail is provided on the workbench, and the containing plate is slidably connected to the slide rail via the first sliding block.

[0016] Furthermore, the clamping assembly includes two first clamping plates symmetrically arranged in the placement groove and a second clamping plate arranged in the groove, and cross bars are connected to the two end surfaces of the two first clamping plates that are opposite to each other, one end of the cross bar passes through a first through hole opened on the inner wall of the placement groove and is placed inside the receiving plate and then hinged to one end of a two connecting rod, and the other end of the two symmetrical two connecting rods is hinged to the piston end of a third cylinder, and the third cylinder is vertically fixed inside the receiving plate; the second clamping plate is connected to the piston end of a fourth cylinder, and the fourth cylinder is obliquely fixed inside the receiving plate, and the piston end of the fourth cylinder passes through the second through hole opened in the groove and then is connected to the second clamping plate.

[0017] Furthermore, the ends of two adjacent symmetrical connecting rods are hinged via a pin, and the pin is connected to the piston end of the third cylinder via a connecting rod.

[0018] Furthermore, a glue layer is provided on the inner walls of the first clamping plate and the second clamping plate.

[0019] Furthermore, the fourth cylinder is obliquely connected to the inside of the containing plate via a fixing rod.

[0020] Furthermore, both ends of the lifting plate are connected with second sliding blocks, a sliding groove is provided on the inner wall of the support frame, and the lifting plate is slidably connected to the sliding groove through the second sliding block.

[0021] Compared with the prior art, the beneficial technical effects of the present invention are:

[0022] The present invention firmly fixes the test tube in the placement groove through the clamping component to ensure its verticality, which is convenient for the subsequent injection of amplification reagents, and controls the lifting and lowering of the injection group through the second cylinder. The amplification reagents are delivered to multiple groups of test tubes at the same time through the injection component, which prevents time differences in the addition of amplification reagents and increases detection accuracy. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] The present invention will be further described below in conjunction with the accompanying drawings.

[0024] Figure 1 This is a front view of the cardiovascular disease detection device of the present invention;

[0025] Figure 2 It is a side view of the cardiovascular disease detection device of the present invention;

[0026] Figure 3 This is a front view of the interior of the cardiovascular disease detection device of the present invention;

[0027] Figure 4 Based Figure 3 Enlarged view of point A

[0028] Figure 5 This is a top view of the interior of the cardiovascular disease detection device of the present invention;

[0029] Figure 6 A top view of the containing components;

[0030] Figure 7 It is a front cross-sectional view of the containing component;

[0031] Figure 8 It is a side sectional view of the containing assembly;

[0032] Explanation of the accompanying drawings: 1. workbench; 2. first cylinder; 3. support frame; 4. second cylinder; 5. holding plate; 6. placement slot; 7. groove; 8. lifting plate; 9. liquid tank; 10. pump; 11. syringe; 12. liquid inlet pipe; 13. liquid dispensing pipe; 14. protective cover one; 15. protective cover two; 16. observation window; 17. handle; 18. first slider; 19. slide rail; 20. first clamping plate; 21. second clamping plate; 22. cross bar; 23. first through hole; 24. second connecting rod; 25. third cylinder; 26. fourth cylinder; 27. second through hole; 28. fixing rod; 29. ​​second slider; 30. slide groove. DETAILED DESCRIPTION

[0033] like Figure 1-8 As shown, a cardiovascular disease detection device includes a workbench 1 and a containing assembly slidably connected to the top surface of the workbench 1, wherein the containing assembly is controlled to move longitudinally by a first cylinder 2 installed on the workbench 1, an injection assembly is provided above the containing assembly, both ends of the injection assembly are slidably connected to a support frame 3, the support frame 3 is fixed on the workbench 1, and the injection assembly is controlled to move vertically by a second cylinder 4 installed on the support frame 3.

[0034] The holding assembly includes a hollow holding plate 5, a first slider 18 is connected to the bottom surface of the holding plate 5, a slide rail 19 is provided on the workbench 1, and the holding plate 5 is slidably connected to the slide rail 19 through the first slider 18. The piston end of the first cylinder 2 is connected to the holding plate 5, and a plurality of placement grooves 6 are provided on the top surface of the holding plate 5, the bottom of the placement groove 6 is a spherical bottom, and a groove 7 is provided at the front end of the placement groove 6, and a clamping assembly is provided in the placement groove 6 and the groove 7.

[0035] The clamping assembly includes two first clamping plates 20 symmetrically arranged in the placement groove 6 and a second clamping plate 21 arranged in the groove 7, and the inner walls of the first clamping plates 20 and the second clamping plates 21 are both provided with a glue layer. The two opposite end faces of the two first clamping plates 20 are both connected with a cross bar 22, one end of the cross bar 22 passes through the first through hole 23 opened on the inner wall of the placement groove 6 and is placed inside the holding plate 5 and then hinged with one end of the second connecting rod 24, and the other ends of the two symmetrical second connecting rods 24 are hinged with the piston end of the third cylinder 25, and the third cylinder 25 is vertically fixed inside the holding plate 5; the second clamping plate 21 is connected with the piston end of the fourth cylinder 26, and the fourth cylinder 26 is tiltedly fixed inside the holding plate 5 through a fixing rod 28, and the piston end of the fourth cylinder 26 passes through the second through hole 27 opened on the groove 7 and then is connected with the second clamping plate 21.

[0036] The ends of two adjacent symmetrical second connecting rods 24 are hinged via a pin, and the pin is connected to the piston end of the third cylinder 25 via a connecting rod.

[0037] The injection assembly includes a lifting plate 8 and a liquid tank 9 connected to the rear end surface of the lifting plate 8. Both ends of the lifting plate 8 are slidably connected to the support frame 3. Both ends of the lifting plate 8 are connected to second sliders 29. A slide groove 30 is provided on the inner wall of the support frame 3. The lifting plate 8 is slidably connected to the slide groove 30 through the second slider 29. The top surface of the lifting plate 8 is connected to the piston end of the second cylinder 4. The front end surface of the lifting plate 8 is connected to pumps 10 corresponding to the placement grooves 6. The liquid outlet end of the pump 10 is connected to a syringe 11 pointing vertically downward. The liquid inlet end of the pump 10 is connected to a liquid inlet pipe 12. The other end of the liquid inlet pipe 12 passes through the lifting plate 8 and is connected to a liquid dispensing pipe 13. The liquid dispensing pipe 13 is connected to the liquid tank 9.

[0038] A controller for controlling the first cylinder 2, the second cylinder 4, the clamping assembly and the injection assembly is installed on the workbench 1. The controller is a prior art and the specific structure will not be described in detail here.

[0039] A protective component is provided on the outer side of the support frame 3, and the protective component includes a protective cover 14 fixed on the workbench 1 and a protective cover 2 15 hinged on the protective cover 14. The protective cover 14 and the protective cover 2 15 form a complete protective cover buckled on the workbench 1, and the protective cover 2 15 is provided with an observation window 16. A handle 17 is connected to the front end surface of the protective cover 2 15.

[0040] The action process of the present invention is as follows:

[0041] When in use, the staff opens the protective cover 15, then puts each test tube into the placement slot 6, and then controls the clamping assembly through the controller on the equipment to clamp the test tube so that the test tube is set vertically and perpendicular to the workbench 1, and then covers the protective cover 15, controls the first cylinder 2 through the controller to drive the holding plate 5 to move backward, so that the holding plate 5 is placed under the injection assembly, and then the second cylinder 4 controls the lifting plate 8 to descend, so that the bottom of the syringe 11 is inserted into the test tube, and then the pump 10 starts working, so that the amplification reagent comes out of the liquid tank 9 and enters each syringe 11 through the liquid dispensing tube 13 and the liquid inlet tube 12, and is injected into the test tube. After the injection is completed, each structure is reset, the protective cover 15 is opened, and the test tube is taken out.

[0042] The embodiments described above are only descriptions of the preferred modes of the present invention, and are not intended to limit the scope of the present invention. Without departing from the design spirit of the present invention, various modifications and improvements made to the technical solutions of the present invention by ordinary technicians in this field should all fall within the protection scope determined by the claims of the present invention.

Claims

1. A cardiovascular disease detection device, characterized in that: It comprises a workbench (1) and a containing assembly slidably connected to the top surface of the workbench (1), wherein the containing assembly is controlled to move longitudinally by a first cylinder (2) installed on the workbench (1), an injection assembly is arranged above the containing assembly, and both ends of the injection assembly are slidably connected to a support frame (3), wherein the support frame (3) is fixed on the workbench (1), and the injection assembly is controlled to move vertically by a second cylinder (4) installed on the support frame (3); The containing assembly comprises a hollow containing plate (5), the piston end of the first cylinder (2) is connected to the containing plate (5), a plurality of placing grooves (6) are provided on the top surface of the containing plate (5), the bottom of the placing groove (6) is a spherical bottom, a groove (7) is provided at the front end of the placing groove (6), and a clamping assembly is provided in the placing groove (6) and the groove (7); The injection assembly comprises a lifting plate (8) and a liquid tank (9) connected to the rear end surface of the lifting plate (8); the two ends of the lifting plate (8) are slidably connected to the support frame (3); the top surface of the lifting plate (8) is connected to the piston end of the second cylinder (4); the front end surface of the lifting plate (8) is connected with pumps (10) corresponding in number to the placement grooves (6); the liquid outlet end of the pump (10) is connected to a syringe (11) pointing vertically downward; the liquid inlet end of the pump (10) is connected to a liquid inlet pipe (12); the other end of the liquid inlet pipe (12) passes through the lifting plate (8) and is connected to a liquid dispensing pipe (13); and the liquid dispensing pipe (13) is connected to the liquid tank (9).

2. The cardiovascular disease detection device according to claim 1, characterized in that: A protective assembly is provided on the outer side of the support frame (3), the protective assembly comprising a protective cover 1 (14) fixed on the workbench (1) and a protective cover 2 (15) hinged on the protective cover 1 (14), the protective cover 1 (14) and the protective cover 2 (15) forming a complete protective cover buckled on the workbench (1).

3. The cardiovascular disease detection device according to claim 2, characterized in that: The second protective cover (15) is provided with an observation window (16).

4. The cardiovascular disease detection device according to claim 2, characterized in that: A handle (17) is connected to the front end surface of the second protective cover (15).

5. The cardiovascular disease detection device according to claim 1, characterized in that: A first sliding block (18) is connected to the bottom surface of the containing plate (5), a sliding rail (19) is provided on the workbench (1), and the containing plate (5) is slidably connected to the sliding rail (19) via the first sliding block (18).

6. The cardiovascular disease detection device according to claim 1, characterized in that: The clamping assembly comprises two first clamping plates (20) symmetrically arranged in the placement groove (6) and a second clamping plate (21) arranged in the groove (7); the two end surfaces of the two first clamping plates (20) facing each other are connected with cross bars (22); one end of the cross bar (22) passes through a first through hole (23) opened on the inner wall of the placement groove (6) and is placed in the interior of the holding plate (5) and is hinged to one end of a second connecting rod (24); the other ends of the two symmetrical second connecting rods (24) are hinged to the piston end of a third cylinder (25); the third cylinder (25) is vertically fixed in the interior of the holding plate (5); the second clamping plate (21) is connected to the piston end of a fourth cylinder (26); the fourth cylinder (26) is obliquely fixed in the interior of the holding plate (5); the piston end of the fourth cylinder (26) passes through a second through hole (27) opened in the groove (7) and is connected to the second clamping plate (21).

7. The cardiovascular disease detection device according to claim 6, characterized in that: The ends of two adjacent symmetrical second connecting rods (24) are hingedly connected via a pin, and the pin is connected to the piston end of the third cylinder (25) via a connecting rod.

8. The cardiovascular disease detection device according to claim 6, characterized in that: The inner walls of the first clamping plate (20) and the second clamping plate (21) are both provided with a glue layer.

9. The cardiovascular disease detection device according to claim 6, characterized in that: The fourth cylinder (26) is obliquely connected to the interior of the containing plate (5) via a fixing rod (28).

10. The cardiovascular disease detection device according to claim 1, characterized in that: Both ends of the lifting plate (8) are connected to second sliders (29), a slide groove (30) is provided on the inner wall of the support frame (3), and the lifting plate (8) is slidably connected to the slide groove (30) via the second slider (29).

Citation Information

Patent Citations

  • Immune quantitative detection device, detection method and application of cardiovascular disease markers

    CN112485432A

  • Detection system of miRNA marker for cardiovascular disease diagnosis

    CN115125125A