A fasting weight loss paste prescription and preparation method thereof

Abstract

The present invention discloses a fasting weight loss paste formula and its preparation method. The composition is a combination of ginseng, kudzu root, lotus seeds, polygonatum, astragalus, red dates, licorice, resistant dextrin, konjac flour, and isomaltooligosaccharide, which synergistically enhances the body's metabolism and promotes fat consumption, thereby achieving the effect of weight loss.

Description

Technical Field

[0001] The present application specifically relates to a fasting weight loss paste prescription and a preparation method thereof. Background Art

[0002] There are many ways to lose weight. Intermittent fasting is a popular way for young people to lose weight. The calorie intake can be controlled by alternating between a normal diet and a low-calorie diet. However, during a low-calorie diet, the sudden decrease in food intake often leads to damage to the spleen and stomach or unsatisfied appetite, thereby increasing food intake. Therefore, it is necessary to provide a composition that can reduce appetite by regulating blood sugar, and can nourish the spleen and stomach under a low-calorie diet, thereby reducing the damage to the spleen and stomach caused by intermittent fasting. Summary of the Invention

[0003] The purpose of the present invention is to provide a fasting weight loss paste prescription and a preparation method thereof, which adopts a compound of plant ingredients, has high safety, good taste, and has the effect of significantly improving metabolism and promoting fat consumption.

[0004] In order to achieve the above object, the present invention adopts the following technical solutions:

[0005] In a first aspect, the present invention provides a fasting weight loss paste comprising the following raw materials in parts by weight: 2-4 parts of ginseng, 1-3 parts of kudzu root, 1-3 parts of lotus seeds, 1-2 parts of polygonatum, 5-13 parts of astragalus, 1-3 parts of red dates, 1-2 parts of licorice, 3-6 parts of resistant dextrin, 8-10 parts of konjac flour, and 5-10 parts of isomaltooligosaccharide.

[0006] Preferably, the fasting slimming cream comprises the following raw materials in parts by mass: 3 parts of ginseng, 2 parts of kudzu root, 2 parts of lotus seeds, 1 part of polygonatum, 10 parts of astragalus, 2 parts of red dates, 1 part of licorice, 5 parts of resistant dextrin, 9 parts of konjac flour, and 7 parts of isomaltooligosaccharide.

[0007] Preferably, the fasting slimming cream comprises the following raw materials in parts by mass: 4 parts of ginseng, 3 parts of kudzu root, 3 parts of lotus seeds, 1 part of polygonatum, 5 parts of astragalus, 3 parts of red dates, 2 parts of licorice, 6 parts of resistant dextrin, 10 parts of konjac flour, and 5 parts of isomaltooligosaccharide.

[0008] Preferably, the fasting slimming cream comprises the following raw materials in parts by mass: 2 parts of ginseng, 1 part of kudzu root, 1 part of lotus seeds, 2 parts of polygonatum, 13 parts of astragalus, 1 part of red dates, 1 part of licorice, 3 parts of resistant dextrin, 8 parts of konjac flour, and 10 parts of isomaltooligosaccharide.

[0009] In a second aspect, the present invention provides a method for preparing the fasting slimming cream described in the first aspect, the specific steps being as follows:

[0010] S1. Weigh ginseng, kudzu root, lotus seeds, polygonatum, astragalus, red dates, liquorice, resistant dextrin, konjac flour, and isomaltooligosaccharide according to the formula;

[0011] S2. The weighed ginseng, kudzu root, lotus seed, polygonatum, astragalus, red dates, and licorice were mixed and evenly mixed to obtain a mixed powder, and ultrasonically extracted with a 65% v / v ethanol solution at 75-90°C and 100-120w for 2-4h, filtered, and the filtrate was collected. The ethanol was distilled under reduced pressure and the filtrate was concentrated to a clear paste A for later use; wherein the mass ratio of the mixed powder to the 65% v / v ethanol solution is 1:4-6, and the water content of the clear paste A is 15-20wt%;

[0012] S3. Mixing the clear paste A with sterile deionized water, sucrose, and soluble starch to obtain a mixed solution, sterilizing the mixed solution instantaneously, and adding 2.5511 of gum red yeast CGMCC, 1.3014 of bifidobacterium catenulum CGMCC, and 1.2190 of bifidobacterium adolescentis CGMCC to the mixed solution for anaerobic fermentation. After the fermentation is completed, ultrasonic homogenization is performed, insoluble matter is filtered out, high-pressure sterilization is performed, and rotary evaporation is performed to concentrate the clear paste B with a water content of 15-20wt%; wherein the mass ratio of clear paste A, sterile deionized water, sucrose, and soluble starch is 1:20-30:4-6:2-4, the mass ratio of gum red yeast, bifidobacterium catenulum, and bifidobacterium adolescentis is 1:0.5-0.7:0.3-0.5, the total amount of gum red yeast, bifidobacterium catenulum, and bifidobacterium adolescentis added is 3-5wt% of the clear paste A, the fermentation starting temperature is 25-30°C, and the fermentation time is 12-16h;

[0013] S4, put the clear paste B in an electric frying pan, heat it on an induction cooker, stir while heating, and add resistant dextrin, konjac flour, and oligosaccharide. When the "hanging flag" phenomenon appears, the fasting slimming cream is obtained;

[0014] The ginseng, kudzu root, lotus seed, polygonatum, astragalus, red dates and liquorice are all dry powders.

[0015] Compared with the prior art, the invention has the following beneficial effects: the invention provides a fasting weight loss paste and a preparation method thereof, wherein the fasting weight loss paste adopts ginseng, kudzu root, lotus seed, polygonatum, astragalus, red dates, licorice and resistant dextrin, konjac powder and isomaltooligosaccharide, which are both medicinal and edible. Ginseng has the effect of invigorating qi and strengthening spleen, which can enhance the spleen and stomach transportation and transformation function, reduce fat accumulation, and the ginsenosides and other ingredients contained in it can regulate metabolism and promote fat burning; the puerarin and other ingredients contained in kudzu root can improve blood circulation, promote metabolism, and contribute to the decomposition of fat; lotus seed has the effects of invigorating spleen and stopping diarrhea, nourishing heart and calming mind, etc., which can help regulate the body's water balance and reduce edema; polygonatum has the effects of invigorating qi and nourishing yin, invigorating spleen and moistening lung and benefiting kidney, which can enhance the body's metabolic capacity and promote the conversion and utilization of fat; astragalus can invigorate qi and strengthen the exterior, promote diuresis and reduce swelling, and has a good weight loss effect on obesity caused by qi deficiency; red dates can invigorate the middle and replenish qi, It nourishes blood and calms the mind, and has a positive effect on regulating metabolic balance and promoting the rational distribution of fat. Licorice has the function of harmonizing various medicines and can alleviate the strong effects of other medicinal materials. At the same time, it itself has the effect of strengthening the spleen and replenishing qi, which helps to improve the body's metabolism. The above 7 Chinese herbal medicines act synergistically on the human body's metabolic system through their respective characteristics and mechanisms of action. Among them, ginseng and astragalus can enhance the body's metabolic capacity, kudzu root and lotus seeds can help regulate the body's water balance and promote blood circulation, polygonatum and red dates can supplement nutrition and promote the rational distribution of fat, and licorice harmonizes various medicines, making the effects of the above medicinal materials more synergistic and mild. In addition, compared with the traditional decoction mode, the present invention first extracts ginseng, kudzu root, lotus seeds, polygonatum, astragalus, red dates and licorice with alcohol, and then introduces specific strains for fermentation, so that the sugars, polyphenols and flavonoids in ginseng, kudzu root, lotus seeds, polygonatum, astragalus, red dates and licorice are fully released, which is more conducive to human absorption. DETAILED DESCRIPTION

[0016] In order to better understand the present invention, the present invention is further described below in conjunction with specific examples. The terms used in the examples are for describing specific embodiments and do not constitute a limitation on the scope of protection of the present invention.

[0017] The experimental methods in the following examples, where specific conditions are not specified, are generally based on conventional conditions or conditions recommended by the manufacturer. Unless otherwise specified, percentages and parts are calculated by weight.

[0018] Some of the raw materials and their sources are as follows:

[0019] Astragalus: Longxi Yifang Pharmaceutical Co., Ltd.

[0020] Ginseng: Guangdong Huidakang Pharmaceutical Co., Ltd.;

[0021] Pueraria root: Zhejiang Yifang Pharmaceutical Co., Ltd.

[0022] Lotus seeds: Guangxi Nanyao Pharmaceutical Co., Ltd.

[0023] Red dates: Leling Maoyuan Red Dates Purchasing and Sales Co., Ltd.

[0024] Polygonatum sibiricum: Longxi Yifang Pharmaceutical Co., Ltd.

[0025] Licorice: Longxi Yifang Pharmaceutical Co., Ltd.

[0026] After purchasing, the above raw materials need to be cleaned, removed from impurities, dried to constant weight, ground into powder, passed through a 60-mesh sieve, and then stored in a sealed container away from light.

[0027] Isomaltooligosaccharide: Shuowei Nutrition Technology (Guangzhou) Co., Ltd.

[0028] Resistant dextrin: Guangzhou Daoming Chemical Co., Ltd.

[0029] Konjac flour: Henan Xinchun Food Co., Ltd.

[0030] Rat ghrelin ELISA kit: purchased from Wuhan Saipei Biotechnology Co., Ltd., catalog number: SP13329.

[0031] The mass ratio of each raw material of the fasting slimming cream is as follows:

[0032] Composition 1: 3 parts of ginseng, 2 parts of kudzu root, 2 parts of lotus seeds, 1 part of polygonatum, 10 parts of astragalus, 2 parts of red dates, 1 part of liquorice, 5 parts of resistant dextrin, 9 parts of konjac flour, and 7 parts of isomaltooligosaccharide. The preparation method is as follows:

[0033] S1. Weigh ginseng, kudzu root, lotus seeds, polygonatum, astragalus, red dates, liquorice, resistant dextrin, konjac flour, and isomaltooligosaccharide according to the formula;

[0034] S2. The weighed ginseng, kudzu root, lotus seed, polygonatum, astragalus, red dates, and licorice were mixed and evenly mixed to obtain a mixed powder, and ultrasonically extracted with a 65% v / v ethanol solution at 80°C and 110w for 3h, filtered, and the filtrate was collected. The ethanol was distilled under reduced pressure and ethanol was recovered. The filtrate was concentrated to a clear paste A for later use; wherein the mass ratio of the mixed powder to the 65% v / v ethanol solution was 1:5, and the water content of the clear paste A was 17wt%;

[0035] S3. Mixing the clear paste A with sterile deionized water, sucrose, and soluble starch to obtain a mixed solution, sterilizing the mixed solution instantaneously, and adding 2.5511 of gum red yeast CGMCC, 1.3014 of bifidobacterium catenulum CGMCC, and 1.2190 of bifidobacterium adolescentis CGMCC to the mixed solution for anaerobic fermentation. After the fermentation is completed, ultrasonic homogenization is performed, insoluble matter is filtered out, high-pressure sterilization is performed, and rotary evaporation is performed to concentrate the clear paste B with a water content of 18 wt%; wherein the mass ratio of clear paste A, sterile deionized water, sucrose, and soluble starch is 1:25:5:3, the mass ratio of gum red yeast, bifidobacterium catenulum, and bifidobacterium adolescentis is 1:0.6:0.4, the total addition amount of gum red yeast, bifidobacterium catenulum, and bifidobacterium adolescentis is 4 wt% of the clear paste A, the fermentation starting temperature is 27°C, and the fermentation time is 14 h;

[0036] S4. Place the paste B in an electric frying pan and heat it with an induction cooker, stirring while heating. At the same time, add resistant dextrin, konjac flour, and oligosaccharide. When the "hanging flag" phenomenon appears, the fasting slimming paste is obtained.

[0037] Composition 2: 4 parts of ginseng, 3 parts of kudzu root, 3 parts of lotus seeds, 1 part of polygonatum, 5 parts of astragalus, 3 parts of red dates, 2 parts of liquorice, 6 parts of resistant dextrin, 10 parts of konjac flour, and 5 parts of isomaltooligosaccharide. The preparation method is as follows:

[0038] S1. Weigh ginseng, kudzu root, lotus seeds, polygonatum, astragalus, red dates, liquorice, resistant dextrin, konjac flour, and isomaltooligosaccharide according to the formula;

[0039] S2. The weighed ginseng, kudzu root, lotus seed, polygonatum, astragalus, red dates, and licorice were mixed and evenly mixed to obtain a mixed powder, and ultrasonically extracted with a 65% v / v ethanol solution at 75°C and 100w for 4h, filtered, and the filtrate was collected. The ethanol was distilled under reduced pressure and ethanol was recovered. The filtrate was concentrated to a clear paste A for later use; wherein the mass ratio of the mixed powder to the 65% v / v ethanol solution was 1:4, and the water content of the clear paste A was 20wt%;

[0040] S3. Mixing the clear paste A with sterile deionized water, sucrose, and soluble starch to obtain a mixed solution, sterilizing the mixed solution instantaneously, and adding 2.5511 of gum red yeast CGMCC, 1.3014 of bifidobacterium catenulum CGMCC, and 1.2190 of bifidobacterium adolescentis CGMCC to the mixed solution for anaerobic fermentation. After the fermentation is completed, ultrasonic homogenization is performed, insoluble matter is filtered out, high-pressure sterilization is performed, and rotary evaporation is performed to concentrate the clear paste B with a water content of 20 wt%; wherein the mass ratio of clear paste A, sterile deionized water, sucrose, and soluble starch is 1:20:4:2, the mass ratio of gum red yeast, bifidobacterium catenulum, and bifidobacterium adolescentis is 1:0.5:0.3, the total addition amount of gum red yeast, bifidobacterium catenulum, and bifidobacterium adolescentis is 3 wt% of the clear paste A, the fermentation starting temperature is 25°C, and the fermentation time is 12 h;

[0041] S4. Place the paste B in an electric frying pan and heat it with an induction cooker, stirring while heating. At the same time, add resistant dextrin, konjac flour, and oligosaccharide. When the "hanging flag" phenomenon appears, the fasting slimming paste is obtained.

[0042] Composition 3: 2 parts of ginseng, 1 part of kudzu root, 1 part of lotus seed, 2 parts of polygonatum, 13 parts of astragalus, 1 part of red dates, 1 part of liquorice, 3 parts of resistant dextrin, 8 parts of konjac flour, and 10 parts of isomaltooligosaccharide; its preparation method is as follows:

[0043] S1. Weigh ginseng, kudzu root, lotus seeds, polygonatum, astragalus, red dates, liquorice, resistant dextrin, konjac flour, and isomaltooligosaccharide according to the formula;

[0044] S2. The weighed ginseng, kudzu root, lotus seed, polygonatum, astragalus, red dates, and licorice were mixed and evenly mixed to obtain a mixed powder, and ultrasonically extracted with a 65% v / v ethanol solution at 90°C and 120w for 2h, filtered, and the filtrate was collected. The ethanol was distilled under reduced pressure and the filtrate was concentrated to a clear paste A for later use; wherein the mass ratio of the mixed powder to the 65% v / v ethanol solution was 1:6, and the water content of the clear paste A was 15wt%;

[0045] S3. Mixing clear paste A with sterile deionized water, sucrose, and soluble starch to obtain a mixed solution, instantaneously sterilizing the mixed solution, and adding gum red yeast CGMCC: 2.5511, Bifidobacterium catenulum CGMCC: 1.3014, and Bifidobacterium adolescentis CGMCC: 1.2190 to the mixed solution for anaerobic fermentation. After the fermentation is completed, ultrasonic homogenization is performed, insoluble matter is filtered out, high-pressure sterilization is performed, and rotary evaporation is performed to concentrate to a clear paste B with a water content of 15wt%; wherein the mass ratio of clear paste A, sterile deionized water, sucrose, and soluble starch is 1:30:6:4, the mass ratio of gum red yeast, Bifidobacterium catenulum, and Bifidobacterium adolescentis is 1:0.7:0.5, the total addition amount of gum red yeast, Bifidobacterium catenulum, and Bifidobacterium adolescentis is 5wt% of the clear paste A, the fermentation starting temperature is 30°C, and the fermentation time is 16h;

[0046] S4. Place the paste B in an electric frying pan and heat it with an induction cooker, stirring while heating. At the same time, add resistant dextrin, konjac flour, and oligosaccharide. When the "hanging flag" phenomenon appears, the fasting slimming paste is obtained.

[0047] Composition ①: The difference between composition 1 and composition 1 is that the raw material ginseng is missing, and its reduced mass is proportionally distributed to the mass of kudzu root, lotus seeds, polygonatum, astragalus, red dates, and licorice. The preparation method is the same as composition 1.

[0048] Composition ②: Different from composition 1, the raw material Pueraria root is missing, and its reduced mass is proportionally distributed to ginseng, lotus seeds, Polygonatum sibiricum, Astragalus membranaceus, red dates, and licorice. The preparation method is the same as composition 1.

[0049] Composition ③: Different from composition 1, the raw material lotus seeds are missing, and the reduced mass is proportionally distributed to ginseng, kudzu root, polygonatum, astragalus, red dates, and licorice. The preparation method is the same as composition 1.

[0050] Composition ④: Different from composition 1, the raw material Polygonatum sibiricum is missing, and its reduced mass is proportionally distributed to ginseng, kudzu root, lotus seeds, astragalus, red dates, and licorice. The preparation method is the same as composition 1.

[0051] Composition ⑤: Different from composition 1, the raw material Astragalus is missing, and its reduced mass is proportionally distributed to ginseng, kudzu root, lotus seeds, polygonatum, red dates, and licorice. The preparation method is the same as composition 1.

[0052] Composition ⑥: Different from composition 1, the raw material red dates is missing, and its reduced mass is proportionally distributed to ginseng, kudzu root, lotus seeds, polygonatum, astragalus, and licorice. The preparation method is the same as composition 1.

[0053] Composition ⑦: Different from composition 1, the raw material licorice is missing, and its reduced mass is proportionally distributed to ginseng, kudzu root, lotus seeds, polygonatum, astragalus, and red dates. The preparation method is the same as composition 1.

[0054] Composition ⑧: Different from composition 1, it lacks the raw material resistant dextrin, and its reduced mass is proportionally distributed to konjac flour and isomaltooligosaccharide. The preparation method is the same as composition 1.

[0055] Composition 9: The difference from composition 1 is that the raw material konjac flour is missing, and the reduced mass thereof is proportionally distributed to resistant dextrin and isomaltooligosaccharide. The preparation method is the same as composition 1.

[0056] Composition ⑩: Different from composition 1, it lacks the raw material isomaltooligosaccharide, and its reduced mass is proportionally distributed to resistant dextrin and konjac flour. The preparation method is the same as composition 1.

[0057] Composition Compared with composition 1, step S4 is not performed, and the clear paste B prepared in step S3 is directly used as the final product.

[0058] Composition : Compared with composition 1, in step S4, the paste B is replaced with deionized water of equal mass.

[0059] Composition The preparation method of is different from that of composition 1 in that only red yeast rice is used for fermentation, the total amount of added bacteria remains unchanged, and the remaining steps are the same as those of composition 1.

[0060] Composition The preparation method is different from that of composition 1 in that only Bifidobacterium catenulatum is used for fermentation, the total amount of bacteria added remains unchanged, and the remaining steps are the same as those of composition 1.

[0061] Composition The preparation method is different from that of composition 1 in that only Bifidobacterium adolescentis is used for fermentation, the total amount of bacteria added remains unchanged, and the remaining steps are the same as those of composition 1.

[0062] Composition The preparation method is different from that of composition 1 in that red yeast rice, bifidobacterium catenella, and bifidobacterium adolescentis are fermented in a mass ratio of 0.3:1:0.5, the total amount of added strains remains unchanged, and the remaining steps are the same as those of composition 1.

[0063] Composition The preparation method is different from that of composition 1 in that cerevisiae CGMCC: 2.3973 is used instead of red yeast CGMCC: 2.5511, the total amount of added strains remains unchanged, and the remaining steps are the same as those of composition 1.

[0064] Composition The preparation method is different from that of composition 1 in that Bifidobacterium bifidum CGMCC: 1.5091 of equal mass is used to replace Bifidobacterium catenulum CGMCC: 1.3014 and Bifidobacterium adolescentis CGMCC: 1.2190, the total amount of added strains remains unchanged, and the remaining steps are the same as those of composition 1.

[0065] Experiment 1: Animal experimental study

[0066] Experimental animals: SD rats, male, weighing 200 ± 20 g, SPF grade, provided by Guangzhou Mingxun Biotechnology Co., Ltd., experimental animal use license: SCXK (Guangdong) 2024-0070.

[0067] Housing conditions: Animals were housed in metabolic cages, maintaining a circadian rhythm, at room temperature of 22-25°C, relative humidity of 55-75%, with free access to food and water.

[0068] Drug samples: Compositions 1-3, composition ①- The recommended oral dose for an adult (60 kg) is 15 g three times a day, equivalent to a rat dose of 4.69 g / kg. When feeding, distilled water is used to prepare the corresponding concentration.

[0069] Obese rat modeling: SD rats were selected and adaptively raised for 5 days. Ten rats were randomly selected as the normal control group and the rest as the model group. The model group used a high-fat diet and the normal control group used a regular diet. They were raised for eight weeks, during which the rats had free access to water and food. The food intake, body weight, and body length were recorded weekly.

[0070] Animal administration: After successful modeling, the obese rats in the model group were randomly divided into 22 groups, namely the model control group and the experimental group, with 5 rats in each group. Among them, the experimental group was gavaged with the corresponding dose of composition 1-3, ①- The model control group was gavaged with an equal amount of distilled water. All groups were given the drug once a day for 4 consecutive weeks. The normal control group consisted of normal rats, and the drug administration pattern was the same as that of the model control group.

[0071] Record: Food intake and body weight were recorded weekly. After 4 weeks of administration, the rats were anesthetized with ether (no food or water for 12 h before anesthesia). When the rats were completely unconscious, blood was drawn from their abdominal arteries for Experiment 2. The rats were then killed and dissected. The perinephric and perinephric fat pads and omental fat were separated and weighed. The fat body ratio (%) was calculated according to the formula: (perinephric fat + perinephric fat + omental fat) / body weight × 100%.

[0072] Statistical analysis: Origin8 was used for statistical analysis. The experimental data were expressed as mean ± standard deviation. One-way analysis of variance was used for comparison between groups. P < 0.05 (*) indicates that the difference is statistically significant.

[0073] Test results:

[0074] Table 1 Compositions 1-3, Composition ①- The weight gain and body fat ratio of rats (mean ± standard deviation, n = 5)

[0075]

[0076]

[0077] Note: “*” indicates p < 0.05 compared with the normal control group; “#” indicates p < 0.05 compared with the model control group.

[0078] The results in Table 1 show that compositions 1-3 have a significant weight loss effect compared with the model control group and the normal control group.

[0079] Comparison of composition 1 with compositions ①-⑦ showed that there was a certain synergistic effect between the ginseng, kudzu root, lotus seed, polygonatum, astragalus, red dates and liquorice described in the present invention.

[0080] Comparison of composition 1 with compositions ⑧-⑩ showed that there was a certain synergistic effect among the resistant dextrin, konjac flour and isomaltooligosaccharide of the present invention.

[0081] Comparative composition 1 and composition - The results show that there is a certain synergistic effect between the ginseng, kudzu root, lotus seed, polygonatum, astragalus, red dates, licorice and resistant dextrin, konjac flour and isomaltooligosaccharide.

[0082] Comparative composition 1 and composition - The results showed that fermentation with specific strains and a certain dosage ratio had a certain synergistic effect.

[0083] Experiment 2: Determination of the effect of the composition on satiety in rats

[0084] Ghrelin is a hormone that can increase appetite, allowing the body to consume more food, absorb more calories and store more fat. Its concentration is positively correlated with hunger.

[0085] In Experiment 1, composition 1 and composition , composition Blood samples from rats in the model control group were collected through the abdominal aorta and centrifuged in batches in a whole blood centrifuge. The supernatant was collected, packaged, and placed in a -80℃ refrigerator for testing.

[0086] The serum was tested using a rat ghrelin ELISA kit (catalog number: SP13329) according to the kit instructions. The test results are shown in Table 2 below.

[0087] Ghrelin content relative to model control group / % = (1-(model control group-composition group) / model control group) × 100%

[0088] Table 2 Effect of the composition on ghrelin

[0089]

[0090] Note: “#” represents p < 0.05 compared with the model control group.

[0091] According to Table 2, composition 1 can significantly reduce the concentration of ghrelin in rats, and the comparison between composition 1 and composition , composition The data show that there is a synergistic effect between ginseng, kudzu root, lotus seeds, polygonatum, astragalus, red dates, licorice and resistant dextrin, konjac flour and oligosaccharide in the composition of the present application.

[0092] Test 3: Acute toxicity test

[0093] Experimental animals: SD rats. The selection conditions refer to Experiment 1.

[0094] Experimental drug: Composition 1, the recommended oral dose for an adult (60 kg) is 15 g / time, three times a day, equivalent to a rat dose of 4.69 g / kg. For feeding, distilled water was used to prepare the appropriate concentration.

[0095] Experimental method: Two SD rats were selected, fasted for 12 hours before administration, and then gavage was performed with 4.69g / kg of the drug. The rats' reactions were observed. The results showed that no animals died due to the administration. Due to the limitations of drug concentration and administration volume, the LD50 could not be determined, so a maximum tolerance test was performed.

[0096] Maximum tolerance test method: 10 SD rats were selected and fasted for 12 hours before administration. They were gavaged with 2-10 times the unit dose, with a unit dose of 4.69g / kg. The control group was gavaged with an equal amount of distilled water. The rats were observed for 7 days after administration, and the rats' body weight, mental state, activity, fur gloss, appetite, excretion, death and other symptoms were recorded.

[0097] The experimental results showed that after 7 days of administration, no adverse reactions were observed. The rats were healthy and lively, with abnormal reactions in spirit, activity, fur, appetite and excretion. The weight of rats in each group increased, and there was no death. After autopsy, there was no obvious abnormal change in the rats in each group.

[0098] The embodiments described above are part of the embodiments of the present application, rather than all of the embodiments. The detailed description of the embodiments of the present application is not intended to limit the scope of the present application for protection, but merely represents selected embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without making creative efforts are within the scope of protection of the present application.

Claims

1. A fasting slimming cream, characterized in that: The invention is composed of the following raw materials in parts by weight: 2-4 parts of ginseng, 1-3 parts of kudzu root, 1-3 parts of lotus seeds, 1-2 parts of polygonatum, 5-13 parts of astragalus, 1-3 parts of red dates, 1-2 parts of liquorice, 3-6 parts of resistant dextrin, 8-10 parts of konjac flour, and 5-10 parts of isomaltooligosaccharide. The preparation method of the slimming cream comprises the following steps: S1. Weigh ginseng, kudzu root, lotus seeds, polygonatum, astragalus, red dates, liquorice, resistant dextrin, konjac flour, and isomaltooligosaccharide according to the formula; S2. Mix the weighed ginseng, kudzu root, lotus seed, polygonatum, astragalus, red dates, and liquorice to obtain a mixed powder, extract the mixture with a 65% v / v ethanol solution under ultrasonic conditions of 75-90°C and 100-120W for 2-4 hours, filter, collect the filtrate, and distill under reduced pressure to recover the ethanol. Concentrate the filtrate to obtain a clear paste A for later use; wherein the mass ratio of the mixed powder to the 65% v / v ethanol solution is 1:4-6, and the water content of the clear paste A is 15-20wt%; S3. Mixing the clear paste A with sterile deionized water, sucrose, and soluble starch to obtain a mixed solution, sterilizing the mixed solution instantaneously, and adding 2.5511 of gum red yeast CGMCC, 1.3014 of bifidobacterium catenulum CGMCC, and 1.2190 of bifidobacterium adolescentis CGMCC to the mixed solution for anaerobic fermentation. After the fermentation is completed, ultrasonic homogenization is performed, insoluble matter is filtered out, high-pressure sterilization is performed, and rotary evaporation is performed to concentrate the clear paste B with a water content of 15-20wt%; wherein the mass ratio of clear paste A, sterile deionized water, sucrose, and soluble starch is 1:20-30:4-6:2-4, the mass ratio of gum red yeast, bifidobacterium catenulum, and bifidobacterium adolescentis is 1:0.5-0.7:0.3-0.5, the total amount of gum red yeast, bifidobacterium catenulum, and bifidobacterium adolescentis added is 3-5wt% of the clear paste A, the fermentation starting temperature is 25-30°C, and the fermentation time is 12-16h; S4. Place the paste B in an electric frying pan and heat it with an induction cooker, stirring while heating. At the same time, add resistant dextrin, konjac flour, and oligosaccharide. When the "hanging flag" phenomenon appears, the fasting slimming paste is obtained.

2. The fasting slimming cream according to claim 1, wherein It is composed of the following raw materials in parts by weight: 3 parts of ginseng, 2 parts of kudzu root, 2 parts of lotus seeds, 1 part of polygonatum, 10 parts of astragalus, 2 parts of red dates, 1 part of liquorice, 5 parts of resistant dextrin, 9 parts of konjac flour, and 7 parts of isomaltooligosaccharide.

3. The fasting slimming cream according to claim 1, wherein It is composed of the following raw materials in parts by weight: 4 parts of ginseng, 3 parts of kudzu root, 3 parts of lotus seeds, 1 part of polygonatum, 5 parts of astragalus, 3 parts of red dates, 2 parts of liquorice, 6 parts of resistant dextrin, 10 parts of konjac flour, and 5 parts of isomaltooligosaccharide.

4. The fasting slimming cream according to claim 1, wherein It is composed of the following raw materials in parts by weight: 2 parts of ginseng, 1 part of kudzu root, 1 part of lotus seed, 2 parts of polygonatum, 13 parts of astragalus, 1 part of red dates, 1 part of liquorice, 3 parts of resistant dextrin, 8 parts of konjac flour, and 10 parts of isomaltooligosaccharide.

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