A Yao medicine composition for treating dry mouth after radiotherapy of nasopharyngeal carcinoma
By using a Yao medicine composition containing medicinal materials such as Wuzhimaotao, the treatment problem of dry mouth after radiotherapy of nasopharyngeal carcinoma, especially dry mouth with Qiyin deficiency type was solved, and the effect of significantly improving the symptoms of dry mouth and improving the quality of life of patients was achieved.
Patent Information
- Application Number
- CN202510009858.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-01-03
- Publication Date
- 2025-04-04
AI Technical Summary
Dry mouth disease after radiotherapy for nasopharyngeal carcinoma is a common complication, and the existing treatment methods are not effective, especially the lack of effective treatment plans for dry mouth disease with Qi and Yin deficiency.
A Yao medicine composition is adopted, including five-finger peach, sarcopene, rehmannia glutinosa, ophiopogon japonicus, samadhi, samadhi, samadhi, lily, dendrobium, wolfberry, black plum, angelica, white peony, dandelion and licorice. Through the effects of helping yang to transform qi, nourishing qi and yin, and promoting fluid and quenching thirst, it significantly improves the symptoms of dry mouth.
The Yao medicine composition significantly improved the symptoms of dry mouth after radiotherapy of nasopharyngeal carcinoma, especially for dry mouth with Qi and Yin deficiency, and improved the patient's quality of life.
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Abstract
Description
Technical Field
[0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a Yao medicine composition related to xerostomia after radiotherapy of nasopharyngeal carcinoma. Background Art
[0002] Nasopharyngeal carcinoma belongs to the category of "lost honor" and "ear, nose and throat cancer" in traditional Chinese medicine. Radiotherapy is the first choice of treatment. Salivary glands are highly sensitive to radiation. The radiation loss of salivary glands during radiotherapy is the root cause of xerostomia after radiotherapy. Traditional Chinese medicine believes that radiation is a toxic evil with "hot" properties. "Heat is a yang evil, which is easy to cause sores and carbuncles." It acts on the nasopharynx and neck, causing dry mouth, red and swollen throat, lip and mouth erosion, local skin redness, burning pain; "heat evil is easy to consume qi and hurt body fluids", so most patients also show thirst and love to drink, dry throat and dry mouth, fatigue and short breath, short and red urine, constipation, red tongue with little moss and thin pulse, etc., which are signs of severe heat and damage to yin. Radiotherapy is the first choice of treatment. Studies have shown that the 5-year survival rate of nasopharyngeal carcinoma receiving radiotherapy in the early stage is about 80%, but due to damage to salivary glands such as parotid glands and submandibular glands during radiotherapy, xerostomia is a common complication, which often accompanies lifelong and seriously affects the quality of life of patients. Western medicine treatment methods include salivary gland replacement, antibacterial flushing, pilocarpine, gargle, drug spraying, etc., but the effect is poor. Traditional Chinese medicine has unique advantages in treating radiotherapy side effects.
[0003] Clinically, dry mouth after radiotherapy for nasopharyngeal carcinoma is often accompanied by Yin deficiency and internal heat, Qi and Yin deficiency, and lung and stomach Yin deficiency. Wu Liangcun believed that the lung Yin was often damaged at the beginning, and the treatment should be to clear away heat and detoxify, nourish Yin and moisten the lungs, and the prescription was Xinjia Shashen Maidong Decoction. Gradually, the evil heat and toxicity entered the interior, and Liangge San and Sijunzi Decoction were selected for modification. When the evil heat stayed for a long time, the true Yin was robbed, and Zhibai Dihuang Wan combined with Zengye Decoction should be used for modification to restore the true Yin. He Ruoping proposed that the Yin deficiency and fire type of dry mouth after radiotherapy for head and neck malignant tumors is more common. You Jianliang agreed that replenishing Qi and nourishing Yin is the main method. Prescriptions such as Pseudostellaria baicalensis, Asparagus cochinchinensis, Ophiopogon japonicus, Adenophora australis, Adenophora scabra, and Rehmannia glutinosa are often used. Wang Rong et al. also believed that dry mouth after radiotherapy is mostly due to Qi and Yin deficiency, and they self-prescribed Yiqi Yangyin Shengjin Decoction. Zhu Ying et al. also self-prescribed Fuzheng Qingbi Recipe to replenish the deficiency of Qi and Yin. Wang Ruiping combined the emotional changes of patients after they became ill and proposed that the syndrome was qi and yin were damaged and liver was depressed. Zhang Yunfang et al. observed that stomach yin deficiency was also quite common. Therefore, the treatment with Jiawei Zengye Decoction was effective. Yan Bo believed that the yin fluid of the lung and stomach was lost after a long period of radiotherapy, and proposed the treatment of Yangyin Qingyanyin. Many reports all used the method of nourishing yin and promoting body fluid as the treatment principle. Although some effects were achieved, the therapeutic effect was not significant. Summary of the invention
[0004] The present invention provides a Yao medicine composition for treating xerostomia after radiotherapy for nasopharyngeal carcinoma. The Yao medicine composition has the effects of promoting yang and transforming qi, nourishing qi and yin, and promoting the production of body fluid and quenching thirst, so the Yao medicine composition has a significant therapeutic effect on xerostomia after radiotherapy for nasopharyngeal carcinoma.
[0005] In order to solve the above technical problems, the technical solution adopted by the present invention is: The invention is prepared from the following raw materials: five-fingered peach, adenophora, raw rehmannia root, ophiopogon japonicus, radix trichosanthis, polygonatum odoratum, lily, dendrobium, wolfberry, black plum, angelica, white peony root, dandelion and liquorice.
[0006] In the above technical scheme, a more specific technical scheme is: the weight parts of each raw material are as follows: 15-18 portions of Prunus mume, 28-30 portions of Adenophora radix, 28-30 portions of Rehmannia root, 18-20 portions of Ophiopogon japonicus, 28-30 portions of Radix Trichosanthis, 12-15 portions of Polygonatum odoratum, 28-30 portions of Lilium, 12-15 portions of Dendrobium candidum, 18-20 portions of Lycium barbarum, 18-20 portions of Prunus mume, 18-20 portions of Angelica sinensis, 18-20 portions of White Peony Root, 10-12 portions of Taraxacum herb, and 8-10 portions of Licorice.
[0007] Further, the weight parts of each raw material are as follows: 15 parts of Rhizoma Cibotii, 28 parts of Radix Adenophorae, 28 parts of Radix Rehmanniae, 18 parts of Radix Ophiopogonis, 28 parts of Radix Trichosanthis, 12 parts of Polygonatum odoratum, 28 parts of Lilium, 12 parts of Herba Dendrobii, 18 parts of Lycium barbarum, 18 parts of Prunus mume, 18 parts of Radix Angelicae Sinensis, 18 parts of Radix Paeoniae Alba, 10 parts of Herba Taraxaci, and 8 parts of Radix Glycyrrhizae.
[0008] Further, the weight parts of each raw material are as follows: 16 parts of Rhizoma Cibotii, 29 parts of Radix Adenophorae, 29 parts of Radix Rehmanniae, 19 parts of Radix Ophiopogonis, 29 parts of Radix Trichosanthis, 14 parts of Polygonatum odoratum, 29 parts of Lilium, 14 parts of Herba Dendrobii, 19 parts of Lycium barbarum, 19 parts of Prunus mume, 19 parts of Radix Angelicae Sinensis, 19 parts of Radix Paeoniae Alba, 11 parts of Herba Taraxaci, and 9 parts of Radix Glycyrrhizae.
[0009] Further, the weight parts of each raw material are as follows: 18 parts of Prunus mume, 30 parts of Adenophora Root, 30 parts of Radix Rehmanniae, 20 parts of Radix Ophiopogonis, 30 parts of Radix Trichosanthis, 15 parts of Polygonatum odoratum, 30 parts of Lilium, 15 parts of Dendrobium, 20 parts of Lycium barbarum, 20 parts of Prunus mume, 20 parts of Angelica sinensis, 20 parts of White Peony Root, 12 parts of Taraxacum Herba, and 10 parts of Licorice.
[0010] Furthermore, the Yao medicine composition for treating dry mouth after radiotherapy for nasopharyngeal carcinoma is prepared into a decoction for oral administration.
[0011] Further, the method comprises the following preparation steps: ①Prescribe the above drugs in proportion; ②Put the prepared medicine into a medicine pot, soak it in water and place it on the fire. Bring it to a boil over high heat first, then simmer over low heat for 15 to 25 minutes, filter and collect the medicine soup.
[0012] Furthermore, before decocting in step ② of the above preparation method, the prepared medicinal materials are soaked for 30 minutes to 60 minutes.
[0013] Furthermore, in winter, warm water at 20°C to 30°C is used to soak the above-mentioned prepared medicinal materials.
[0014] Among them, the five-fingered peach described in the present invention is the root of the Moraceae plant Ficus microcarpa, which is distributed in Guangxi, Guangdong, Guizhou and other places. It is sweet, slightly warm in nature, and enters the spleen, lung and liver meridians. It is also known as five-fingered milk, wild astragalus, wild acanthopanax bark, five-clawed dragon, sow milk, and southern astragalus.
[0015] The Adenophora radix is the dried root of Adenophora verticillata or Adenophora radix of the Campanulaceae family. It is sweet in taste, slightly cold in nature, and enters the lung and stomach meridians. It is also known as Adenophora radix, American ginseng, and Adenophora radix soaked in water.
[0016] The raw rehmannia root is the tuberous root of the plant Rehmannia glutinosa of the Scrophulariaceae family. It is sweet, cold in nature, and enters the heart, liver, and kidney meridians. It has aliases such as rehmannia root, raw rehmannia root, earth marrow, original rehmannia root, dried rehmannia root, benzyl, radix rehmanniae, milk seed, and mother-in-law's milk.
[0017] The Ophiopogon japonicus is a dried tuberous root of a perennial evergreen herb of the genus Ophiopogon in the Liliaceae family. It tastes sweet, slightly bitter, and slightly cold in nature. It enters the heart, lung, and stomach meridians. It has aliases such as Ophiopogon japonicus, Ophiopogon japonicus, Hangzhou Ophiopogon japonicus, Sichuan Ophiopogon japonicus, Cundong, Wheat Ophiopogon japonicus, and Chive Leaf Ophiopogon japonicus.
[0018] The Radix Trichosanthis is the root of the Trichosanthis plant of the Cucurbitaceae family. It tastes sweet and slightly bitter, is slightly cold in nature, and enters the lung and stomach meridians. It is also known as Trichosanthes root, pollen, and Trichosanthes root.
[0019] The Polygonatum odoratum is the dried rhizome of the perennial herb Polygonatum odoratum of the Liliaceae family, also known as Ying, Weiwei, and Nuwei.
[0020] The lily is the dried fleshy scale leaves of Lilium, Lilium or Lilium slender-leaved, which are plants of the Liliaceae family. It is sweet in taste, cold in nature, and enters the heart and lung meridians. It has aliases such as leek, Chongmai, Zhongting, Chongxiang, Moro, Qiangqu, and lily garlic.
[0021] The dendrobium is of the genus Dendrobium of the Orchidaceae family. It is sweet, light and slightly salty in nature, cold in nature, and enters the stomach, kidney, and lung meridians. It has aliases such as Xianhu Lanyun, Immortal Grass, Resurrection Grass, Ziying Fairy Plant, Forest Orchid, Forbidden Life, Du Lan, Golden Hairpin Flower, Millennium Moist, Yellow Grass, and Chlorophytum.
[0022] The wolfberry is the mature fruit of the Solanaceae plant wolfberry or Ningxia wolfberry. It tastes sweet, is neutral in nature, and enters the liver and kidney meridians. It is also known as beet seed, red earring, and ground bone seed.
[0023] The black plum is the dried nearly mature fruit of the deciduous tree plant plum of the Rosaceae family. It tastes sour and astringent, is neutral in nature, and enters the liver, spleen, lung, and large intestine meridians. It has aliases such as plum fruit, black plum, smoked plum, orange plum meat, plum, and spring plum.
[0024] The angelica is the root of the angelica root of the Umbelliferae family, which is sweet in taste and warm in nature. It enters the liver, heart and spleen meridians. Its aliases are dried angelica, Qin Na, western angelica, Min angelica, golden angelica, angelica body, Han Gui Wei, angelica song, earth angelica, Qin Gui, Yun Gui, mountain Qi, white Qi, and Wen Wu.
[0025] The white peony root is the dried root of the Ranunculaceae plant Paeonia lactiflora. It tastes bitter and sour, is slightly cold in nature, and enters the liver and spleen meridians. It is also known as white peony and golden peony.
[0026] The dandelion is a perennial herb of the Asteraceae family. It tastes bitter, is sweet and cold in nature, and enters the liver and stomach meridians. It has aliases such as Huanghua Yeding, Dandelion, and Huahualang.
[0027] The licorice is the dried root and rhizome of the leguminous plants licorice, licorice inflated fruit or licorice glabra. It is sweet in taste, neutral in nature, and enters the heart, lung, spleen, and stomach meridians. It is also known as sweet grass root, red licorice, powdered licorice, powdered grass, fur grass, stick grass, Ural licorice, and sweet grass.
[0028] By adopting the above technical solution, the beneficial effects obtained by the present invention are: 1. In the present invention, the Yao medicine five-fingered ginseng is the main medicine, which warms and dredges the meridians, assists yang and transforms qi, and is matched with white peony root and angelica to dredge the meridians and promote blood circulation, nourish yin and blood as the ministerial medicine, and the adenophora, raw rehmannia, ophiopogon, trichosanthes, polygonatum, lily, dendrobium, and wolfberry fruit in the prescription can nourish qi, nourish yin and moisten dryness; dandelion clears away heat and detoxifies, and black plum is sour and sweet to nourish yin as the adjuvant medicine, and liquorice can nourish qi and detoxify, and harmonize the various medicines as the guiding medicine.
[0029] 2. The Yao medicine Wuzhimaotao of the present invention is sweet and slightly warm in nature. Most nasopharyngeal carcinoma patients suffer from qi and yin deficiency after radiotherapy. In previous studies, it was found that the Yao medicine Wuzhimaotao warming medicine combined with a large amount of yin-nourishing medicine can seek yin in yang, and is better for treating dry mouth than simply nourishing yin and producing body fluid. The combination provides a new idea of Yao medicine compatibility for treating dry mouth after radiotherapy of nasopharyngeal carcinoma with significant effect, low price and convenient use. In the present invention, the medication mechanism has three aspects: first, taking its slightly warming medicine property and combining it with a large amount of yin-nourishing medicine can reduce fire and warm yang to help the gasification of body fluid, and prevent large Fire burns body fluid, so it is a good product for seeking Yin in Yang; secondly, a large number of yin-nourishing medicines are bitter and cold medicines, and bitter and cold medicines hinder the normal distribution of body fluids and cannot achieve the purpose of nourishing yin and producing body fluids. In order to prevent bitter and cold medicines from hurting the middle, the five-fingered ginseng, which is a product that warms the middle and helps yang, is added to slightly raise yang to eliminate this drawback; thirdly, the five-fingered ginseng is an authentic medicinal material in the Lingnan region and a commonly used Yao medicine in Guangxi. Nasopharyngeal carcinoma patients are also a common and frequently occurring disease in Guangdong and Guangxi. The principle of Chinese medicine formula adapted to local conditions is adopted and the effect is significant. Based on the above, the present invention can achieve the purpose of treating nasopharyngeal carcinoma of Qi and Yin deficiency type xerostomia. DETAILED DESCRIPTION
[0030] The present invention is further described in detail below in conjunction with specific embodiments: Example 1 - A Yao medicine composition for treating dry mouth after radiotherapy for nasopharyngeal carcinoma The Yao medicine composition for treating xerostomia after radiotherapy of nasopharyngeal carcinoma of Qi and Yin deficiency type of this embodiment is prepared by the following components in parts by weight: 15 parts of Rhizoma Cibotii, 28 parts of Radix Adenophorae, 28 parts of Radix Rehmanniae, 18 parts of Radix Ophiopogonis, 28 parts of Radix Trichosanthis, 12 parts of Polygonatum odoratum, 28 parts of Lilium, 12 parts of Herba Dendrobii, 18 parts of Lycium barbarum, 18 parts of Prunus mume, 18 parts of Radix Angelicae Sinensis, 18 parts of Radix Paeoniae Alba, 10 parts of Herba Taraxaci, and 8 parts of Radix Glycyrrhizae.
[0031] Its production method is: 1.1 Soaking Pour the medicine into the medicine pot and spread it flat, then add cold water until it is fully soaked, and soak for half an hour or an hour. In winter, soak it in warm water of 20 to 30 degrees to shorten the boiling time, but do not soak it in boiling water. The soaking time should not be too long, especially in summer, to avoid enzymatic hydrolysis of the medicine.
[0032] 1.2 Decoction After soaking, add quinquefolius, adenophora, raw rehmannia, ophiopogon, radix trichosanthis, polygonatum, lily, dendrobium, wolfberry, ebony, angelica, white peony, dandelion and licorice and boil the medicine over high heat for 10 minutes, then simmer for about 15-25 minutes over low heat.
[0033] 1.3 Directions Take one dose daily, decoct in water to obtain 400ml of juice, take twice a day, morning and evening, one course of treatment for one week, and continuous treatment for 2 courses.
[0034] Example 2 - A Yao medicine composition for treating dry mouth after radiotherapy for nasopharyngeal carcinoma The Yao medicine composition for treating xerostomia after radiotherapy of nasopharyngeal carcinoma of Qi and Yin deficiency type of this embodiment is prepared by the following components in parts by weight: 16 parts of Rhizoma Cibotii, 29 parts of Radix Adenophorae, 29 parts of Radix Rehmanniae, 19 parts of Radix Ophiopogonis, 29 parts of Radix Trichosanthis, 14 parts of Polygonatum odoratum, 29 parts of Lilium, 14 parts of Herba Dendrobii, 19 parts of Lycium barbarum, 19 parts of Prunus mume, 19 parts of Radix Angelicae Sinensis, 19 parts of Radix Paeoniae Alba, 11 parts of Herba Taraxaci, and 9 parts of Radix Glycyrrhizae.
[0035] The above Chinese medicine composition is used as an effective ingredient to prepare a decoction, and its preparation method and administration method are the same as those in Example 1.
[0036] Example 3 - A Yao medicine composition for treating dry mouth after radiotherapy for nasopharyngeal carcinoma The Yao medicine composition for treating xerostomia after radiotherapy of nasopharyngeal carcinoma of Qi and Yin deficiency type of this embodiment is prepared by the following components in parts by weight: 18 parts of Prunus mume, 30 parts of Adenophora Root, 30 parts of Radix Rehmanniae, 20 parts of Radix Ophiopogonis, 30 parts of Radix Trichosanthis, 15 parts of Polygonatum odoratum, 30 parts of Lilium, 15 parts of Dendrobium, 20 parts of Lycium barbarum, 20 parts of Prunus mume, 20 parts of Angelica sinensis, 20 parts of White Peony Root, 12 parts of Taraxacum Herba, and 10 parts of Licorice.
[0037] The above Chinese medicine composition is used as an effective ingredient to prepare a decoction, and its preparation method and administration method are the same as those in Example 1.
[0038] Effect test part: In order to better study the effect of five-fingered peach on radiotherapy of nasopharyngeal carcinoma, the applicant applied to the Guangxi Zhuang Autonomous Region Traditional Chinese Medicine Administration in 2023 for a self-raised research project entitled "Clinical Research on the Treatment of Salivary Gland Injury in Nasopharyngeal Carcinoma by Using Five-fingered Peach to Treat Yangzhongqiuyin" and was approved. During the research process, the applicant conducted the following efficacy tests: The following data are clinical observation data. The enrolled population is 120 patients diagnosed with nasopharyngeal carcinoma. After radiotherapy, they were diagnosed with Qi and Yin deficiency syndrome. They were randomly divided into a treatment group and a control group with 60 cases in each group. One dose was taken daily, 400ml of decoction was taken twice a day, morning and evening, one week as one course of treatment. After two courses of treatment, the degree of dry mouth and irritated saliva flow were observed: The drugs in the treatment group were 18g of Fructus Ophiopogonis, 30g of Adenophora Root, 30g of Rehmannia Glutinosa, 20g of Ophiopogon japonicus, 30g of Radix Trichosanthis, 15g of Polygonatum odoratum, 30g of Lilium, 15g of Dendrobium officinale, 20g of Lycium barbarum, 20g of Prunus mume, 20g of Angelica sinensis, 12g of White Peony Root, 12g of Taraxacum Herba, and 10g of Licorice.
[0039] The drugs in the control group were 30g of Adenophora Root, 30g of Rehmannia Glutinosa, 20g of Ophiopogon japonicus, 30g of Radix Trichosanthis, 15g of Polygonatum odoratum, 30g of Lilium Bulb, 15g of Dendrobium Officinale, 20g of Lycium barbarum, 20g of Prunus mume, 20g of Angelica sinensis, 12g of White Peony Root, 12g of Taraxacum Herba, and 10g of Licorice.
[0040] The results are as follows: Table 1 Comparison of efficacy of 120 patients before and after treatment (n=60) Compared with the same group before treatment, P < 0.01; compared with the control group after treatment, P < 0.01.
[0041] Table 2 Comparison of comprehensive efficacy between the two groups [n(%)] Compared with the control group, X=5.783, P<0.05.
[0042] Specific case introduction: 1. Patient Feng, male, 64 years old Chief complaint: Recurrent nose bleeding for 2 months, worsening for 2 days Current medical history: The patient reported that he had nose bleeding without obvious cause 2 months ago, and the blood was light red. He was hospitalized for nasopharyngeal endoscopy and pathologically diagnosed with nasopharyngeal carcinoma. He underwent radiotherapy, and the nose bleeding worsened 2 days ago. He usually feels tired and short of breath, has dry mouth and thirst, less breath and laziness to speak, fatigue and spontaneous sweating, accompanied by night sweats, hot flashes, palpitations, poor appetite and sleep, normal urination, dry and hard stools, thin tongue, dry and red tongue with little fluid, and a thready pulse.
[0043] TCM diagnosis: Qi and Yin deficiency syndrome Treatment principle: Boost yang and transform qi, nourish qi and yin, promote fluid production and quench thirst Treatment method: 18g of Eleutherodactyla chinensis, 30g of Adenophora radix, 30g of Rehmannia root, 20g of Ophiopogon japonicus, 30g of Radix Trichosanthis, 15g of Polygonatum odoratum, 30g of Lilium, 15g of Dendrobium officinale, 20g of Lycium barbarum, 20g of Prunus mume, 20g of White Peony Root, 20g of Angelica sinensis, 12g of Taraxacum mongolicum, 10g of Licorice, one dose per day, decocted in water to obtain 400ml of juice, taken twice a day, morning and evening, one course of treatment per week, and 2 courses of treatment in a row.
[0044] Efficacy: After treatment, dry mouth improved significantly, nose bleeding decreased, shortness of breath alleviated, spontaneous sweating and night sweats disappeared, the tongue turned light red, the body fluid on the tongue increased compared to before, sleep improved, bowel movements were smooth, and the effect was remarkable.
[0045] 2. Patient Qin Mouheng, male, 58 years old Chief complaint: Nasopharyngeal cancer treatment for more than 5 years, dry mouth for half a year Current medical history: The patient reported that he had nasal congestion and epistaxis since 2020. He went to another hospital for nasopharyngeal endoscopy for non-keratinizing squamous cell carcinoma of the nasopharynx, and then underwent concurrent chemoradiotherapy. Half a year ago, the patient developed dry mouth, thirst, polydipsia, difficulty opening the mouth, fatigue and spontaneous sweating, and the effect of self-administered multiple drugs was poor. He had poor appetite, normal sleep, normal urination, dry stool, red tongue with little coating, and thin pulse.
[0046] TCM diagnosis: Qi and Yin deficiency syndrome Treatment principle: Boost yang and transform qi, nourish qi and yin, promote fluid production and quench thirst Treatment method: 18g of Eleutherodactyla chinensis, 30g of Adenophora radix, 30g of Rehmannia root, 20g of Ophiopogon japonicus, 30g of Radix Trichosanthis, 15g of Polygonatum odoratum, 30g of Lilium, 15g of Dendrobium officinale, 20g of Lycium barbarum, 20g of Prunus mume, 20g of White Peony Root, 20g of Angelica sinensis, 12g of Taraxacum mongolicum, 10g of Licorice, one dose per day, decocted in water to obtain 400ml of juice, taken twice a day, morning and evening, one course of treatment per week, and 2 courses of treatment in a row.
[0047] Efficacy: After treatment, dry mouth was significantly reduced, water intake was reduced, fatigue improved, spontaneous sweating decreased, urine was more frequent and clearer than before, and bowel movements were normal.
[0048] 3. Patient Gong Mouhui, male, 69 years old Chief complaint: Nasopharyngeal carcinoma treatment for more than 3 years, dry mouth for 3 months Current medical history: The patient reported that he had a headache in May 2021, hearing loss in the left ear, and bloody mucus. MRI of the nasopharynx showed a mass in the nasopharynx, and nasopharyngeal carcinoma was considered. Nasopharyngeal endoscopic tissue biopsy was performed for non-keratinizing squamous cell carcinoma, and concurrent chemoradiotherapy was performed. Three months ago, the patient developed dry mouth, increased water intake, 6-8 times of drinking water at night, fatigue, spontaneous sweating after activities, poor effect of self-administered multiple drugs, poor appetite, poor sleep, yellow urine, dry and difficult stool, red tongue with little coating, and thin pulse.
[0049] TCM diagnosis: Qi and Yin deficiency syndrome Treatment principle: Boost yang and transform qi, nourish qi and yin, promote fluid production and quench thirst Treatment method: 18g of Eleutherodactyla chinensis, 30g of Adenophora radix, 30g of Rehmannia root, 20g of Ophiopogon japonicus, 30g of Radix Trichosanthis, 15g of Polygonatum odoratum, 30g of Lilium, 15g of Dendrobium officinale, 20g of Lycium barbarum, 20g of Prunus mume, 20g of White Peony Root, 20g of Angelica sinensis, 12g of Taraxacum mongolicum, 10g of Licorice, one dose per day, decocted in water to obtain 400ml of juice, taken twice a day, morning and evening, one course of treatment per week, and 2 courses of treatment in a row.
[0050] Efficacy: After treatment, dry mouth and drinking frequency improved, the patient could sleep peacefully at night, sweating decreased after activities, and bowel movements were normal.
Claims
1. A Yao medicine composition for treating dry mouth after radiotherapy for nasopharyngeal carcinoma, characterized in that Made from the following raw materials: Five-fingered peach, Adenophora, Rehmannia root, Ophiopogon japonicus, Radix Trichosanthis, Polygonatum odoratum, Lilium, Dendrobium, Lycium barbarum, Ebony plum, Angelica sinensis, White peony root, Taraxacum officinale, and Licorice.
2. The herbal medicine composition for treating xerostomia after radiotherapy for nasopharyngeal carcinoma according to claim 1, characterized in that The weight parts of each raw material are as follows: 15-18 portions of Prunus mume, 28-30 portions of Adenophora radix, 28-30 portions of Rehmannia root, 18-20 portions of Ophiopogon japonicus, 28-30 portions of Radix Trichosanthis, 12-15 portions of Polygonatum odoratum, 28-30 portions of Lilium, 12-15 portions of Dendrobium candidum, 18-20 portions of Lycium barbarum, 18-20 portions of Prunus mume, 18-20 portions of Angelica sinensis, 18-20 portions of White Peony Root, 10-12 portions of Taraxacum herb, and 8-10 portions of Licorice.
3. The Yaoyao composition for treating xerostomia after radiotherapy of nasopharyngeal carcinoma according to claim 2, characterized in that The weight parts of each raw material are as follows: 15 parts of Rhizoma Cibotii, 28 parts of Radix Adenophorae, 28 parts of Radix Rehmanniae, 18 parts of Radix Ophiopogonis, 28 parts of Radix Trichosanthis, 12 parts of Polygonatum odoratum, 28 parts of Lilium, 12 parts of Herba Dendrobii, 18 parts of Lycium barbarum, 18 parts of Prunus mume, 18 parts of Radix Angelicae Sinensis, 18 parts of Radix Paeoniae Alba, 10 parts of Herba Taraxaci, and 8 parts of Radix Glycyrrhizae.
4. The Yaoyao composition for treating xerostomia after radiotherapy of nasopharyngeal carcinoma according to claim 2, characterized in that The weight parts of each raw material are as follows: 16 parts of Rhizoma Cibotii, 29 parts of Radix Adenophorae, 29 parts of Radix Rehmanniae, 19 parts of Radix Ophiopogonis, 29 parts of Radix Trichosanthis, 14 parts of Polygonatum odoratum, 29 parts of Lilium, 14 parts of Herba Dendrobii, 19 parts of Lycium barbarum, 19 parts of Prunus mume, 19 parts of Radix Angelicae Sinensis, 19 parts of Radix Paeoniae Alba, 11 parts of Herba Taraxaci, and 9 parts of Radix Glycyrrhizae.
5. The Yaoyao composition for treating xerostomia after radiotherapy for nasopharyngeal carcinoma according to claim 2, characterized in that The weight parts of each raw material are as follows: 18 parts of Prunus mume, 30 parts of Adenophora Root, 30 parts of Radix Rehmanniae, 20 parts of Radix Ophiopogonis, 30 parts of Radix Trichosanthis, 15 parts of Polygonatum odoratum, 30 parts of Lilium, 15 parts of Dendrobium, 20 parts of Lycium barbarum, 20 parts of Prunus mume, 20 parts of Angelica sinensis, 20 parts of White Peony Root, 12 parts of Taraxacum Herba, and 10 parts of Licorice.
6. The Yaoyao composition for treating xerostomia after radiotherapy of nasopharyngeal carcinoma according to claim 1, 2, 3, 4 or 5, characterized in that: The Yao medicine composition for treating xerostomia after radiotherapy of nasopharyngeal carcinoma is prepared into a decoction for oral administration.
7. The Yaoyao composition for treating xerostomia after radiotherapy for nasopharyngeal carcinoma according to claim 6, characterized in that The method comprises the following preparation steps: ①Prescribe the above drugs in proportion; ②Put the prepared medicine into a medicine pot, soak it in water and place it on the fire. Bring it to a boil over high heat first, then simmer over low heat for 15 to 25 minutes, filter and collect the medicine soup.
8. The Yaoyao composition for treating xerostomia after radiotherapy of nasopharyngeal carcinoma according to claim 7, characterized in that: Before decocting in step ② of the above preparation method, soak the prepared medicinal materials for 30 to 60 minutes.
9. The Yaoyao composition for treating xerostomia after radiotherapy of nasopharyngeal carcinoma according to claim 8, characterized in that: In winter, use warm water at 20℃ ~ 30℃ to soak the above-mentioned medicinal materials.