A strong sealing antibacterial marker pen and preparation method thereof

Abstract

The present application relates to the field of marker writing, and in particular to a strong sealing antibacterial marker and a preparation method thereof, comprising an ink sac and ink stored in the ink sac; the ink comprises the following components by weight: 50-60 parts of aqueous self-crosslinking acrylic emulsion, 10-20 parts of titanium dioxide, 1-5 parts of organic dispersant, 5-10 parts of color paste, 5-8 parts of wetting agent, 10-20 parts of filler, 10-20 parts of water and 10-20 parts of antibacterial preparation; the antibacterial preparation comprises quaternary ammonium salt, grapefruit seed extract powder and acetic acid. The preparation method of the present application has the advantage of enhancing the antibacterial property of marker ink.

Description

Technical Field

[0001] The present application relates to the field of marker pen writing, and in particular to a strong sealing antibacterial marker pen and a preparation method thereof. Background Art

[0002] A marker pen is a common writing and drawing tool, which usually has a slender body and a sharp tip. The ink of a marker pen is usually drawn out from the built-in ink bag or ink box through the pen tip, and can be written or drawn directly on paper. Markers have distinct and bright colors and are suitable for scenes such as painting, marking, marking, tracing and writing. They are widely used in work, study, art and crafts. According to the different properties of the ink in the built-in ink bag of the marker pen, the marker pen can be divided into water-based marker pen, alcohol-based marker pen, oil-based marker pen, etc.

[0003] Due to the contact between the pen tip and the outside world, some bacteria or fungi can easily enter the ink sac through the pen tip, and then decompose the organic components in the ink, causing the ink to gradually deteriorate, shortening the shelf life of the ink and losing its original fluidity and writing properties. At the same time, after some bacteria or bacteria multiply in the ink, they may gather at the pen tip or the part where the ink flows. Their gathering may cause the ink channel to be blocked, preventing the ink from flowing normally and affecting the writing experience.

[0004] Among them, the inks of water-based markers and oil-based markers usually do not have antibacterial properties. The inks of alcohol-based markers usually use ethanol (alcohol) as the main solvent. Although it can play a certain antibacterial role, due to the strong volatility of ethanol, alcohol-based markers usually have a pungent smell when used, and alcohol-based markers are easy to dry up if not used for a long time or stored improperly. Summary of the invention

[0005] In order to enhance the antibacterial property of marker pen ink, the present application provides a strong sealing antibacterial marker pen and a preparation method thereof.

[0006] The present application provides a strong sealing antibacterial marker pen and a preparation method thereof using the following technical solutions: In the first aspect, the present application provides a strong sealing antibacterial marker pen, which adopts the following technical solution: A strong sealing antibacterial marker comprises an ink sac and ink stored in the ink sac; the ink comprises the following components in parts by weight: 50-60 parts of water-based self-crosslinking acrylic emulsion, 10-20 parts of titanium dioxide, 1-5 parts of organic dispersant, 5-10 parts of color paste, 5-8 parts of wetting agent, 10-20 parts of filler, 10-20 parts of water and 10-20 parts of antibacterial preparation; the antibacterial preparation comprises quaternary ammonium salt, grapefruit seed extract powder and acetic acid.

[0007] By adopting the above technical solution, traditional water-based markers and oil-based markers generally do not have antibacterial functions, which can easily lead to deterioration of the ink, thereby shortening the service life of the markers.

[0008] The sealed antibacterial marker pen of the present application includes an ink sac and ink stored in the ink sac, wherein the ink includes a self-crosslinking acrylic emulsion, titanium dioxide, an organic dispersant, a color paste, a wetting agent, a filler and an antibacterial agent; the antibacterial agent includes a quaternary ammonium salt, grapefruit seed extract powder and acetic acid. By adding the antibacterial agent to the ink formula, the antibacterial property of the ink is greatly improved, thereby reducing the survival of fungi in the ink, thereby reducing the deterioration of the ink and extending the service life of the marker pen.

[0009] After being hydrolyzed in water, quaternary ammonium disinfectants carry a positive charge, adsorb on the surface of microorganisms, form ion micelles, and gradually penetrate into the lipid layer and protein layer of the cytoplasm, thereby changing the permeability of the cell membrane, causing the cell contents to extravasate, leading to the death of microorganisms, and thus playing a disinfecting role. However, quaternary ammonium disinfectants hydrolyze quickly in water and usually have the problem of short antibacterial efficacy. Grapefruit seed powder is a natural antibacterial agent that contains flavonoids and glycosides, which have shown antibacterial and antioxidant properties in many studies. Grapefruit seed powder can inhibit bacterial growth and replication and has a broad spectrum of antimicrobial activity, including bacteria, fungi and viruses. The cross-linking of grapefruit seed powder and quaternary ammonium salts produces a synergistic effect, which increases the antibacterial duration of quaternary ammonium salts, enhances antibacterial properties, expands the antibacterial range, and reduces the risk of microbial resistance to a single antibacterial agent. Finally, by adding acetic acid, the dissociation equilibrium of flavonoids and quaternary ammonium salts is adjusted to a lower pH (acidic) condition, which can increase their charge density and enhance the cross-linking effect. Acidic conditions can change the charge distribution on the surface of the substance and promote the adsorption and cross-linking of flavonoids and quaternary ammonium salts.

[0010] Preferably, the antibacterial preparation is composed of quaternary ammonium salt, grapefruit seed powder and acetic acid in a ratio of (5-10):(5-10):(3-5).

[0011] By adopting the above technical solution, the ink is modified by using an antibacterial preparation composed of quaternary ammonium salt, grapefruit seed powder and acetic acid in a ratio of (5-10):(5-10):(3-5), so that the ink has strong antibacterial properties, thereby extending the service life of the ink.

[0012] Preferably, the antibacterial preparation is composed of quaternary ammonium salt, grapefruit seed powder and acetic acid in a ratio of 2:2:1.

[0013] By adopting the above technical solution, the ink modified with an antibacterial preparation composed of quaternary ammonium salt, grapefruit seed powder and acetic acid in a ratio of 2:2:1 has the best antibacterial performance, thereby further extending the service life of the ink.

[0014] Preferably, the grapefruit seed powder is grapefruit seed powder that is easily soluble in water.

[0015] By adopting the above technical solution, since grapefruit seed powder contains a large amount of cellulose, the solubility of grapefruit seed powder in water is relatively low. By using grapefruit seed powder that is easily soluble in water, the grapefruit seed powder can be dispersed more evenly in water.

[0016] Preferably, the preparation steps of the water-soluble grapefruit seed powder are as follows: suspending maltodextrin in an appropriate amount of water, then adding the grape seed powder thereto, and fully mixing the maltodextrin and the grapefruit seed powder by stirring or ultrasonic treatment, and drying to obtain the water-soluble grapefruit seed powder.

[0017] By adopting the above technical solution, since grapefruit seed powder contains a large amount of cellulose, the solubility of grapefruit seed powder in water is relatively low. By wrapping the grapefruit seed powder with maltodextrin, the glucose seed powder can be dispersed more evenly in water.

[0018] Preferably, the preparation steps of the water-soluble grapefruit seed powder are as follows: adding an appropriate amount of water to the grapefruit seed powder to fully moisten it; heating the mixture of grapefruit seed powder and water to a high temperature and boiling it for 30 minutes to 1 hour; finally, drying the grapefruit seed powder to obtain the water-soluble grapefruit seed powder.

[0019] By adopting the above technical solution, the fiber structure and cell wall of the grapefruit seed powder are destroyed by high-temperature cooking, making it easier to dissolve in water, thereby promoting the release and dissolution of flavonoids and bitter glycosides in the grapefruit seed powder.

[0020] Preferably, the quaternary ammonium salt is one or a combination of two of cetyltrimethylammonium chloride and cetyltrimethylammonium bromide.

[0021] Preferably, the organic dispersant is a polycarboxylate dispersant.

[0022] Preferably, the wetting agent is a nonionic wetting agent.

[0023] In a second aspect, the present application provides a method for preparing a strong sealing antibacterial marker pen, using the following technical solution: A method for preparing a strong sealing antibacterial marker pen comprises the following steps: S1: mixing titanium dioxide, sodium polycarboxylate, color paste, polyoxyethylene alkylamine, calcium carbonate, kaolin and water to obtain a first premix; S2: Mixing the aqueous self-crosslinking acrylic emulsion, polyoxyethylene alkylamine and water, stirring and filtering to obtain a second premix; S3: Adding 3 kg of water to acetic acid, hexadecyltrimethylammonium chloride and water-soluble grapefruit seed powder and mixing them thoroughly to obtain a third premix; S4: mixing the first premix, the second premix and the third premix, stirring for 20-30 minutes to obtain ink; S4: Pour ink into the ink bag, and then assemble it in the pen case to obtain a strong sealing antibacterial marker pen.

[0024] By adopting the above technical solution, the highly sealed antibacterial marker pen prepared by the above method includes a pen shell, an ink sac arranged in the pen shell, and ink filled in the ink sac. Since the ink has been modified by the antibacterial preparation, it has strong antibacterial properties, so that the prepared marker pen has better antibacterial properties.

[0025] In summary, the present application includes at least one of the following beneficial technical effects: 1. After being hydrolyzed in water, quaternary ammonium disinfectants carry a positive charge, adsorb on the surface of microorganisms, form ion micelles, and gradually penetrate into the lipid layer and protein layer of the cytoplasm, thereby changing the permeability of the cell membrane, causing the cell contents to extravasate, leading to the death of microorganisms, and thus playing a disinfecting role. However, quaternary ammonium disinfectants hydrolyze quickly in water and usually have the problem of short antibacterial effectiveness. Grapefruit seed powder is a natural antibacterial agent that contains flavonoids and bitter glycosides, which have shown antibacterial and antioxidant properties in many studies. Grapefruit seed powder can inhibit bacterial growth and replication and has a broad spectrum of antimicrobial activity, including bacteria, fungi and viruses. The cross-linking of grapefruit seed powder and quaternary ammonium salts produces a synergistic effect, increases the antibacterial duration of quaternary ammonium salts, enhances antibacterial properties, expands the antibacterial range, and reduces the risk of microbial resistance to a single antibacterial agent. Finally, by adding acetic acid, the dissociation equilibrium of flavonoids and quaternary ammonium salts is adjusted to a lower pH (acidic) condition, which can increase their charge density and enhance the cross-linking effect. Acidic conditions can change the charge distribution on the surface of the substance and promote the adsorption and cross-linking of flavonoids and quaternary ammonium salts. DETAILED DESCRIPTION

[0026] The present application is further described in detail below with reference to the embodiments.

[0027] raw material Water-based self-cross-linking acrylic emulsion, titanium dioxide, sodium polycarboxylate, polyoxyethylene alkylamine, color paste, hexadecyltrimethylammonium chloride, hexadecyltrimethylammonium bromide, calcium carbonate, kaolin, and acetic acid were all purchased from Sinopharm Chemical Reagent Co., Ltd.; among them, the particle size of titanium dioxide is less than 100nm, and the particle size of kaolin is 0.5-5μm. Example

[0028] Example 1 A method for preparing a strong sealing antibacterial marker pen comprises the following steps: S1: 15 kg titanium dioxide, 3 kg sodium polycarboxylate, 5 kg color paste, 3 kg polyoxyethylene alkylamine, 6 kg calcium carbonate, 7 kg kaolin and 10 kg water are mixed and stirred to obtain a first premix; S2: 55 kg of aqueous self-crosslinking acrylic emulsion, 3 kg of polyoxyethylene alkylamine and 3 kg of water were mixed, stirred and filtered to obtain a second premix; S3: 3 kg of acetic acid, 6 kg of cetyltrimethylammonium chloride and 6 kg of water-soluble grapefruit seed powder are added with 3 kg of water and mixed thoroughly to obtain a third premix; S4: mixing the first premix, the second premix and the third premix, stirring for 20-30 minutes to obtain ink; S4: Pour ink into the ink bag, and then assemble it in the pen case to obtain a strong sealing antibacterial marker pen.

[0029] The water-soluble grapefruit seed powder in step S2 is prepared by the following steps: adding 10 kg of water to 10 kg of grapefruit seed powder to fully moisten it; heating the mixture of grapefruit seed powder and water to a high temperature and boiling it for 1 hour; and finally drying the grapefruit seed powder to obtain the water-soluble grapefruit seed powder.

[0030] Example 2-19 Based on the method of Example 1, Example 2-19 improves the components and proportions of the ink. The specific adjustments are shown in Table 1 below, wherein the antibacterial preparation is composed of hexadecyltrimethylammonium chloride, grapefruit seed powder and acetic acid in a ratio of 2:2:1.

[0031] Table 1 Components and proportion adjustment table of inks of Examples 1-19 Embodiment 20 Example 20 is based on the method of Example 1, and the ratio of the antibacterial preparation is adjusted. The antibacterial preparation is composed of hexadecyltrimethylammonium chloride, grapefruit seed powder and acetic acid in a ratio of 10:10:3.

[0032] Embodiment 21 Example 21 is based on the method of Example 1, and the ratio of the antibacterial preparation is adjusted. The antibacterial preparation is composed of hexadecyltrimethylammonium chloride, grapefruit seed powder and acetic acid in a ratio of 1:1:1.

[0033] Embodiment 22 Example 22 Based on the method of Example 1, cetyltrimethylammonium chloride is replaced by cetyltrimethylammonium bromide.

[0034] Embodiment 23 Example 23 is based on the method of Example 1 and uses water-soluble grapefruit seed powder modified by maltodextrin. The specific steps are as follows: 10 kg of maltodextrin is suspended in 100 kg of water, and then 10 kg of grape seed powder is added thereto, and the maltodextrin and the grapefruit seed powder are fully mixed by stirring or ultrasonic treatment to obtain the water-soluble grapefruit seed powder.

[0035] Embodiment 24 Example 24 is based on the method of Example 1, except that grapefruit seed powder is directly added without pretreatment.

[0036] Comparative Example Comparative Example 1 Comparative Example 1 is based on the method of Example 1, but no antibacterial agent is added.

[0037] Comparative Example 2 Comparative Example 2 was based on the method of Example 1, but without adding grapefruit seed powder.

[0038] Comparative Example 3 Comparative Example 3 is based on the method of Example 1, but no acetic acid is added.

[0039] Comparative Example 4 Comparative Example 4 is based on the method of Example 1, but no hexadecyltrimethylammonium chloride is added.

[0040] Performance testing In order to further study the effects of various components and preparation parameters on the antibacterial properties of marker pens, the present application further conducts the following examples for verification.

[0041] Test Item 1: The present invention performs a 60-second bactericidal effect test on Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, and Candida albicans; Test Item 2: The present invention conducted a 4-hour long-term antibacterial experiment on Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, and Candida albicans. The test results are shown in Table 2 below.

[0042] Table 2 Antibacterial performance test of ink Referring to Table 2, Examples 1-24 adjusted the components and proportions of the inks, and the test results showed that the inks produced according to the formula of the present application performed well in both short-term and long-term sterilization, and had good bactericidal effects on Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli and Candida albicans, indicating that the inks produced by the formula of the present application have broad-spectrum, long-term antibacterial properties, and strong antibacterial properties. Among them, the ink produced according to the formula in Example 1 has the best antibacterial properties.

[0043] Taking Example 1 as a control, Examples 2-3 adjusted the amount of aqueous self-cross-linking acrylic emulsion added. The test results showed that the inks prepared by adjusting the amount of aqueous self-cross-linking acrylic emulsion added within the range provided in the present application all had good antibacterial properties, among which the amount of aqueous self-cross-linking acrylic emulsion added in Example 1 was optimal.

[0044] Taking Example 1 as a control, the addition amount of titanium dioxide was adjusted in Examples 4-5. The test results showed that the inks prepared by adjusting the addition amount of titanium dioxide within the range provided in the present application all had good antibacterial properties, among which the addition amount of titanium dioxide in Example 1 was optimal.

[0045] Taking Example 1 as a control, Examples 6-7 adjusted the amount of sodium polycarboxylate added. The test results showed that the inks prepared by adjusting the amount of sodium polycarboxylate added within the range provided in the present application all had good antibacterial properties, among which the amount of sodium polycarboxylate added in Example 1 was optimal.

[0046] Taking Example 1 as a control, Examples 8-9 adjusted the amount of polyoxyethylene alkylamine added. The test results showed that the inks prepared by adjusting the amount of polyoxyethylene alkylamine added within the range provided in the present application all had good antibacterial properties, among which the amount of polyoxyethylene alkylamine added in Example 1 was optimal.

[0047] Taking Example 1 as a control, Examples 10-11 adjusted the amount of colorant added. The test results showed that the inks prepared by adjusting the amount of colorant added within the range provided in the present application all had good antibacterial properties, among which the amount of colorant added in Example 1 was optimal.

[0048] Taking Example 1 as a control, Examples 12-15 adjusted the type and amount of filler added. The test results showed that the inks prepared by adjusting the amount of filler added within the range provided in the present application all had good antibacterial properties, and both calcium carbonate and kaolin can be used in the preparation of the ink of the present application. Among them, the type and amount of filler added used in Example 1 are optimal.

[0049] Taking Example 1 as a control, the amount of antibacterial agent added in Examples 16-17 was adjusted. The test results showed that the inks prepared by adjusting the amount of antibacterial agent added within the range provided in the present application all had good antibacterial properties, among which the amount of antibacterial agent added in Example 1 was optimal.

[0050] Taking Example 1 as a control, Examples 18-19 adjusted the amount of solvent added, and the test results showed that the inks prepared by adjusting the amount of water added within the range provided in the present application all had good antibacterial properties, among which the amount of water added used in Example 1 was optimal.

[0051] Taking Example 1 as a control, the formula of the antibacterial preparation and was adjusted in Examples 20-21. The test results showed that the inks prepared by adjusting the formula of the antibacterial preparation and within the scope provided in the present application all had good antibacterial properties, among which the formula of the antibacterial preparation and used in Example 1 was the best.

[0052] Taking Example 1 as a control, Example 23 adjusted the modification method of grapefruit seed powder. The grape seed powder was modified by maltodextrin, which improved the dispersibility of the grapefruit seed powder in water, so that the grapefruit seed powder and the quaternary ammonium salt could be better cross-linked, but the modification effect was not as good as that of Example 1.

[0053] Taking Example 1 as a control, Example 24 added untreated grapefruit seed powder. Since the untreated grapefruit seed powder had poor water solubility, it was difficult to evenly disperse the grapefruit seed powder in water, thereby affecting the cross-linking effect between the grapefruit seed powder and the quaternary ammonium salt.

[0054] Taking Example 1 as a control, no antibacterial agent was added in Example 1, and the antibacterial performance of the ink produced was extremely poor, but it still had certain antibacterial performance, which was speculated to be the antibacterial property produced by titanium dioxide.

[0055] Taking Example 1 as a control, grapefruit seed powder was not added in Comparative Example 2. Although the ink produced had certain antibacterial properties, it was far lower than that of Example 1, and the long-term bactericidal performance was poor. The results showed that grapefruit seed powder could produce a cross-linking synergistic effect with quaternary ammonium salt to improve the antibacterial timeliness of the ink.

[0056] Compared with Example 1, no acetic acid was added in Comparative Example 3. The antibacterial property of the ink produced was better than that of Comparative Example 2 but much lower than that of Example 1. The results showed that the addition of acetic acid could increase the charge density and enhance the crosslinking strength of grapefruit seed powder and quaternary ammonium salt, thereby improving the antibacterial property of the ink.

[0057] Taking Example 1 as a control, no quaternary ammonium salt was added in Comparative Example 4. Although the ink produced had certain antibacterial properties, it was far lower than that of Example 1. The results showed that quaternary ammonium salt could produce a cross-linking synergistic effect with quaternary ammonium salt to improve the broad-spectrum bactericidal effect and bactericidal strength of the ink.

[0058] The above are all preferred embodiments of the present application, and the protection scope of the present application is not limited thereto. Therefore, any equivalent changes made according to the structure, shape, and principle of the present application should be included in the protection scope of the present application.

Claims

1. A strong sealing antibacterial marker pen, characterized by: The invention comprises an ink sac and ink stored in the ink sac; the ink comprises the following components in parts by weight: 50-60 parts of aqueous self-crosslinking acrylic emulsion, 10-20 parts of titanium dioxide, 1-5 parts of organic dispersant, 5-10 parts of color paste, 5-8 parts of wetting agent, 10-20 parts of filler, 10-20 parts of water and 10-20 parts of antibacterial preparation; the antibacterial preparation comprises quaternary ammonium salt, grapefruit seed extract powder and acetic acid.

2. The strong sealing antibacterial marker pen according to claim 2, characterized in that: The antibacterial preparation is composed of quaternary ammonium salt, grapefruit seed powder and acetic acid in a ratio of (5-10):(5-10):(3-5).

3. The strong sealing antibacterial marker pen according to claim 2, characterized in that: The antibacterial preparation is composed of quaternary ammonium salt, grapefruit seed powder and acetic acid in a ratio of 2:2:

1.

4. The strong sealing antibacterial marker pen according to claim 1, characterized in that: The grapefruit seed powder is grapefruit seed powder that is easily soluble in water.

5. The strong sealing antibacterial marker pen according to claim 4, characterized in that: The steps for preparing the water-soluble grapefruit seed powder are as follows: suspending maltodextrin in an appropriate amount of water, and then adding the grape seed powder therein, The maltodextrin and the grapefruit seed powder are fully mixed by stirring or ultrasonic treatment, and the grapefruit seed powder that is easily soluble in water is obtained after drying.

6. The strong sealing antibacterial marker pen according to claim 41, characterized in that: The preparation steps of the water-soluble grapefruit seed powder are as follows: adding an appropriate amount of water to the grapefruit seed powder to fully moisten the grapefruit seed powder; heating the mixture of the grapefruit seed powder and the water to a high temperature and boiling the mixture for 30 minutes to 1 hour; and finally drying the grapefruit seed powder to obtain the water-soluble grapefruit seed powder.

7. The strong sealing antibacterial marker pen according to claim 1, characterized in that: The quaternary ammonium salt is one or a combination of cetyltrimethylammonium chloride and cetyltrimethylammonium bromide.

8. The strong sealing antibacterial marker pen according to claim 1, characterized in that: The organic dispersant is a polycarboxylate dispersant.

9. The strong sealing antibacterial marker pen according to claim 1, characterized in that: The wetting agent is a nonionic wetting agent.

10. A method for preparing the strong sealing antibacterial marker pen according to any of claims 1 to 9, characterized in that: The following steps are involved: S1: mixing titanium dioxide, sodium polycarboxylate, color paste, polyoxyethylene alkylamine, calcium carbonate, kaolin and water to obtain a first premix; S2: mixing the aqueous self-crosslinking acrylic emulsion, the polyoxyethylene alkylamine and water, stirring and filtering to obtain a second premix; S3: adding 3 kg of water to acetic acid, hexadecyltrimethylammonium chloride and grapefruit seed powder soluble in water and mixing them thoroughly to obtain a third premix; S4: mixing the first premix, the second premix and the third premix, and stirring for 20-30 minutes to obtain ink; S5: Pour ink into the ink bag, and then assemble it in the pen case to obtain a strong sealing antibacterial marker pen.

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