Automatic nucleic acid extraction instrument with purification function

Abstract

The invention relates to the technical field of automatic nucleic acid extraction, and discloses an automatic nucleic acid extractor with a purification function, comprising a box, a cleaning component, a cleaning tube, an ultrasonic vibrator, a drying component, a heating wire, a drying tube and a fan. In the invention, multiple groups of cleaning components are filled with different liquids, the first two groups are cleaning liquids, the middle two groups are alcohols, and the last two groups are clean water, which can effectively clean and disinfect a rubber-tipped dropper, prevent cross-contamination of samples, save resources, and reduce costs. The drying component can dry the cleaned rubber-tipped dropper to prevent water drops on the inner wall of the rubber-tipped dropper from affecting the results of the next group of sample detections. The purification component can not only filter impurities in the sample, but also accelerate the mixing of the sample and the reagent, and can also purify the sample.

Description

Technical Field

[0001] The invention relates to the technical field of automatic nucleic acid extraction, in particular to an automatic nucleic acid extractor with a purification function. Background Art

[0002] Automatic nucleic acid extractors are of great significance in biomedical research, clinical diagnosis and disease prevention and control. In molecular biology research, automatic nucleic acid extractors can quickly and efficiently extract DNA or RNA from cell or tissue samples, providing high-quality nucleic acid materials for subsequent molecular biology experiments. This not only simplifies the experimental process, but also improves research efficiency, supporting scientific researchers in exploring the mysteries of life.

[0003] When traditional automatic nucleic acid extractors extract multiple samples in one operation, in order to avoid cross-contamination between samples, their rubber-tipped droppers are all disposable. Although this can avoid cross-contamination, if the number of samples to be tested is large, it will lead to a sharp increase in costs and waste of resources. Summary of the invention

[0004] In order to solve the problems existing in the background technology, the present invention provides an automatic nucleic acid extraction instrument with purification function that can avoid cross contamination between samples and does not require replacement of a rubber-tipped dropper.

[0005] In view of the problems in the prior art, the present invention provides an automatic nucleic acid extractor with a purification function, comprising a box body, multiple groups of cleaning components are installed inside the box body, the interior of the cleaning components includes a fixed box, a water tank, a pump, a cleaning pipe, an ultrasonic vibrator, a flat tube, a hose and a first installation box, the liquid inside the first two groups of cleaning components is cleaning liquid, the liquid inside the middle two groups of cleaning components is alcohol, and the liquid inside the last two groups of cleaning components is clean water, multiple groups of cleaning pipes are fixedly installed inside the first installation box, the ultrasonic vibrator is fixedly installed at the lower end of the cleaning pipe, and the probe of the ultrasonic vibrator is located inside the cleaning pipe, multiple groups of drying components are installed inside the box body, the interior of the drying components includes a second installation box, a heating wire, a drying pipe, a fan, a partition, an electric push rod and a movable plate, the heating wire is fixedly installed inside the second installation box, multiple groups of drying pipes are fixedly installed inside the second installation box and are located below the heating wire, and the fan is fixedly installed at the bottom end of the drying pipe.

[0006] Specifically, the first installation box is installed on one of the groups of second slides, a group of fixed boxes is fixedly installed inside the first installation box, a group of pumps is fixedly installed on one side of the fixed box, the pumps are connected to the cleaning pipes through pipelines, and multiple groups of cleaning pipes are fixedly connected through flat pipes. A group of water tanks is also fixedly installed inside the first installation box, a group of pumps is fixedly installed on one side of the water tanks, the pumps are fixedly connected to one of the groups of cleaning pipes through a hose, and one end of the hose is located at the bottom end of the inside of the cleaning pipe.

[0007] Specifically, the second mounting box is installed on another group of second slide plates. The material of the second mounting box is ethylene foam board. A group of partitions are fixedly installed inside the second mounting box. The partitions are located between the drying tube and the heating wire. The partition material is also ethylene foam board. Through holes are opened on the upper and lower sides of the partitions. Multiple groups of electric push rods are fixedly installed inside the partitions. The output shafts of the electric push rods are fixedly connected to the moving plates. One group of the moving plates is slidably connected to the inner upper end of the partition, and the other group of the moving plates is slidably connected to the inner lower end of the partition.

[0008] Specifically, the box body is slidably installed with a group of sliding bases, and multiple groups of purification components are installed on the sliding bases. The interior of the purification components includes a mixing tube, a third motor, a disc, a mixing cylinder, a conical filter plate and a stirring rod. A group of third motors are fixedly installed inside the mixing tube.

[0009] Specifically, the output shaft of the third motor is fixedly connected to a disc, and the disc is rotatably connected to the inside of a mixing tube. A group of mixing barrels are fixedly installed on the upper end of the mixing tube, and the mixing barrels are rotatably connected to the inside of the mixing tube. The inner wall of the mixing barrel is rotatably connected to the outer wall of a conical filter plate, and the conical filter plate and the mixing tube are fixedly connected. The mixing barrel is divided into two sections, and a plurality of stirring rods are fixedly installed on the lower end of the conical filter plate, and another group of conical sieve plates are fixedly installed on the upper end of the conical filter plate, and the sieve holes of the sieve plates are different from those of the conical filter plates.

[0010] Specifically, a group of moving components are installed inside the box, and the interior of the moving components includes a first motor, a threaded rod, a sleeve plate, a connecting plate, a sleeve fastener, a mounting plate, a second motor, a slider and a slide rail. The first motor is fixedly installed on the inner wall of the box, and the output end of the first motor is fixedly connected to one end of the threaded rod, and the other end of the threaded rod is rotatably connected to the other inner wall of the box.

[0011] Specifically, a group of sleeve plates are threadedly connected to the threaded rod, a group of connecting plates are fixedly connected to the lower end of the sleeve plates, a group of sleeve fasteners are slidably connected to the connecting plates, and the sleeve fasteners are threadedly connected to another group of threaded rods. One end of this group of threaded rods is rotatably connected to the output shaft of a slider, and the slider is fixedly installed on one side of the mounting plate, and the mounting plate is fixedly connected to the connecting plate. A group of sliders are installed at the bottom of the second motor, and the sliders are slidably connected to the inside of the slide rails, and the slide rails are fixedly installed on the inner side walls of the box.

[0012] Specifically, a group of hydraulic rods are fixedly installed on the lower end of the sleeve, a group of connecting blocks are fixedly installed on the output shaft of the hydraulic rods, and a plurality of groups of rubber-tipped droppers are fixedly installed on the lower end of the connecting blocks.

[0013] Specifically, a group of box doors are fixedly installed on one side of the box body, a group of sliding bases are slidably connected to the inside of the box body, a group of sample placement seats are slidably installed to the inside of the box body, two groups of first slides are slidably connected to the inside of the box body, two groups of second slides are slidably connected to the inside of the box body, the sliding base is located between the sample placement seat and a group of first slides, and the second slides are located on one side of the first slides.

[0014] Beneficial effects of the present invention: The multiple groups of cleaning components in the present invention are filled with different liquids, the first two groups are cleaning liquids, the middle two groups are alcohol, and the last two groups are clean water. They can effectively clean and disinfect the rubber-tipped dropper, prevent cross-contamination of samples, and save resources and reduce costs.

[0015] The drying component in the present invention can dry the cleaned rubber-tipped dropper to prevent water drops on the inner wall of the dropper from affecting the test results of the next group of samples.

[0016] The purification component of the present invention can not only filter out impurities in the sample, but also accelerate the mixing of the sample and the reagent, and also has the effect of purifying the sample. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] The present invention is further described below in conjunction with the accompanying drawings and embodiments.

[0018] Figure 1 It is a schematic diagram of the overall structure of the present invention; Figure 2 This is a distribution diagram of the internal parts connection structure of the overall structure of the present invention; Figure 3 A distribution diagram of the connection structure of the internal parts of the mobile assembly in the present invention; Figure 4 This is a distribution diagram of the internal parts of the purification component in the present invention; Figure 5 It is a front cross-sectional view of the cleaning component in the present invention; Figure 6 It is a front cross-sectional view of the drying component in the present invention; Figure 7 is a side sectional view of the drying component of the present invention; Figure 8 for Figure 7 Enlarged view of point A in the middle.

[0019] In the figure: 1. Box body; 12. Box door; 13. Sliding base; 14. Sample placement seat; 15. First slide plate; 16. Second slide plate; 17. Hydraulic rod; 18. Connecting block; 19. Rubber tip dropper; 2. Moving assembly; 21. First motor; 22. Threaded rod; 23. Sleeve plate; 24. Connecting plate; 25. Sleeve fastener; 26. Mounting plate; 27. Second motor; 28. Sliding block; 29. ​​Slide rail; 3. Purification assembly; 31. Mixing tube; 32 , the third motor; 33, the disc; 34, the mixing cylinder; 35, the conical filter plate; 36, the stirring rod; 4, the cleaning assembly; 41, the fixed box; 42, the water tank; 43, the pump; 44, the cleaning pipe; 45, the ultrasonic vibrator; 46, the flat tube; 47, the hose; 48, the first installation box; 5, the drying assembly; 51, the second installation box; 52, the heating wire; 53, the drying tube; 54, the fan; 55, the partition; 56, the electric push rod; 57, the moving plate. DETAILED DESCRIPTION

[0020] In order to make the technical methods, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further described below in conjunction with specific implementation methods.

[0021] like Figure 5 , 6 , 7 and Figure 8As shown, in view of the problems in the prior art, the present invention provides an automatic nucleic acid extractor with a purification function, including an automatic nucleic acid extractor with a purification function, including a box body 1, multiple groups of cleaning components 4 are installed inside the box body 1, the interior of the cleaning components 4 includes a fixed box 41, a water tank 42, a pump 43, a cleaning pipe 44, an ultrasonic vibrator 45, a flat tube 46, a hose 47 and a first installation box 48, the liquid inside the first two groups of the cleaning components 4 is cleaning liquid, the liquid inside the middle two groups of the cleaning components 4 is alcohol, and the liquid inside the last two groups of the cleaning components 4 is clean water, and multiple groups of the cleaning pipes 44 are fixedly installed in the first Inside a mounting box 48, the ultrasonic vibrator 45 is fixedly mounted at the lower end of the cleaning pipe 44, and the probe of the ultrasonic vibrator 45 is located inside the cleaning pipe 44, multiple groups of the drying components 5 are mounted inside the box body 1, and the interior of the drying components 5 includes a second mounting box 51, a heating wire 52, a drying pipe 53, a fan 54, a partition 55, an electric push rod 56 and a moving plate 57, the heating wire 52 is fixedly mounted inside the second mounting box 51, multiple groups of the drying pipe 53 are fixedly mounted inside the second mounting box 51 and are located below the heating wire 52, and the fan 54 is fixedly mounted at the bottom end of the drying pipe 53; The first installation box 48 is installed on one of the groups of second slide plates 16, a group of fixed boxes 41 is fixedly installed inside the first installation box 48, a group of pumps 43 is fixedly installed on one side of the fixed box 41, the pumps 43 are connected to the cleaning pipes 44 through pipelines, and multiple groups of the cleaning pipes 44 are fixedly connected through flat pipes 46, a group of water tanks 42 is also fixedly installed inside the first installation box 48, a group of pumps 43 is fixedly installed on one side of the water tanks 42, the pumps 43 are fixedly connected to one of the groups of cleaning pipes 44 through a hose 47, and one end of the hose 47 is located at the bottom end of the cleaning pipe 44; The second installation box 51 is installed on another group of second slide plates 16. The material of the second installation box 51 is ethylene foam board. A group of partitions 55 are fixedly installed inside the second installation box 51. The partitions 55 are located between the drying tube 53 and the heating wire 52. The material of the partitions 55 is also ethylene foam board. Through holes are opened on the upper and lower sides of the partitions 55. Multiple groups of electric push rods 56 are fixedly installed inside the partitions 55. The output shafts of the electric push rods 56 are fixedly connected to the moving plates 57. One group of the moving plates 57 is slidably connected to the upper end of the interior of the partitions 55, and the other group of the moving plates 57 is slidably connected to the lower end of the interior of the partitions 55.

[0022] (1) While the purification work is being carried out in the present invention, the mobile component 2 will drive the rubber head dropper 19 to the upper end of the first two groups of cleaning components 4, and the corresponding position of the cleaning pipe 44, the hydraulic rod 17 drives the rubber head dropper 19 to move downward, and the rubber head dropper 19 enters the interior of the cleaning pipe 44, and the ultrasonic vibrator 45 is started. At this time, the pump inside the rubber head dropper 19 will continuously draw the cleaning liquid inside the cleaning pipe 44 into the rubber head dropper 19, and then release it. During the repeated suction process, the ultrasonic vibrator 45 will drive the cleaning liquid to vibrate continuously, thereby cleaning the inner wall of the rubber head dropper 19. After the cleaning liquid inside the cleaning pipe 44 is used many times, it will be sucked into the interior by the pump 43 on the side wall of the water tank 42, which is convenient for subsequent cleaning. At this time, the pump 43 on the side wall of the fixed box 41 will pour new cleaning liquid into the interior of the cleaning pipe 44. After the cleaning of the rubber head dropper 19 is completed, the hydraulic rod 17 drives the rubber head dropper 19 to reset, and then drives it to the upper end of the middle group of cleaning components 4, and repeats the above operation. This group The liquid inside is alcohol, which can sterilize the inner and outer walls of the rubber-tipped dropper 19 to prevent cross-contamination of samples in the future. Finally, the moving component 2 is driven to the top of the last two groups of cleaning components 4 to repeat the above operation. The liquid in this group of cleaning components 4 is clean water, which can wash away the alcohol adhering to the inner wall of the rubber-tipped dropper 19. After completing the cleaning work, the moving component 2 will drive the rubber-tipped dropper 19 to the top of the drying component 5, and then the hydraulic rod 17 will drive the rubber-tipped dropper 19 into the interior of the drying tube 53. At this time, the electric push rod 56 contracts and drives the moving plate 57 to move, thereby opening the gap opened on the partition 55. The fan 54 is started and will blow the heat generated by the heating wire 52 to the rubber-tipped dropper 19. The hot air will enter the interior of the rubber-tipped dropper 19, thereby playing a drying role and preventing water droplets from affecting the subsequent sample detection results. The material of the second installation box 51 is ethylene foam board, which has a good thermal insulation effect, so the heat generated by the heating wire 52 will not be dissipated to the interior of the box body 1 in large quantities; In the present invention, each liquid corresponds to two groups of cleaning components 4, which is for multi-layer cleaning on the one hand, and can prevent the situation that when one group of cleaning components 4 is cleaning the waste liquid, there is no other cleaning component 4 to provide cleaning.

[0023] like Figure 2 as well as Figure 4As shown, the sliding installation of the box body 1 has a group of sliding bases 13, and the sliding bases 13 are installed with multiple groups of purification components 3. The interior of the purification component 3 includes a mixing tube 31, a third motor 32, a disc 33, a mixing barrel 34, a conical filter plate 35 and a stirring rod 36. A group of third motors 32 are fixedly installed inside the mixing tube 31, and the output shaft of the third motor 32 is fixedly connected to the disc 33. The disc 33 is rotatably connected to the inside of the mixing tube 31. A group of mixing barrels 34 are fixedly installed on the upper end of the mixing tube 31. The mixing barrel 34 is rotatably connected to the inside of the mixing tube 31. The inner wall of the mixing barrel 34 is rotatably connected to the outer wall of the conical filter plate 35. The conical filter plate 35 and the mixing tube 31 are fixedly connected. The mixing barrel 34 is divided into two sections. The lower end of the conical filter plate 35 is fixedly installed with multiple groups of stirring rods 36. The upper end of the conical filter plate 35 is fixedly installed with another group of conical sieve plates, and the sieve holes of this sieve plate are different from those of the conical filter plate 35.

[0024] (2) In the present invention, the moving component 2 drives the rubber-tipped dropper 19 to place the sucked reagent and sample into the corresponding purification component 3. The conical filter plate 35 inside the purification component 3 can filter the impurities in the sample. After the reagent and sample enter the interior of the purification component 3, the third motor 32 is started, and the third motor 32 drives the disc 33 and the mixing cylinder 34 to rotate. The side wall of the conical filter plate 35 is fixedly connected to the mixing tube 31, and is slidably connected to the outer wall of the mixing cylinder 34, so the conical filter plate 35 is in a stationary state. state, at this time, the stirring rod 36 will continuously stir the sample and reagent mixture to make it more evenly mixed, and the leakage hole set on the conical filter plate 35 is a conical leakage hole. After entering the mixing barrel 34, the substance in the sample begins to react with the reagent, and its volume will increase. When pouring out the sample, these impurities will be blocked by the conical filter plate 35 in the mixing barrel 34, thereby achieving a purification effect. When cleaning it later, you only need to add cleaning liquid, and then open the valve at the outlet on one side of the mixing tube 31 to rinse it; Note: The number of revolutions of the third motor 32 is fixed, and it will return to the initial angle after each rotation, so that the liquid outlet of the mixing barrel 34 and the outlet of the mixing tube 31 correspond to each other, and the mixing barrel 34 is divided into two sections. When the disc 33 rotates, the section at the lower end of the conical filter plate 35 rotates accordingly, while the upper section does not move.

[0025] like Figure 2 as well as Figure 3As shown, a group of moving components 2 are installed inside the box 1, and the interior of the moving component 2 includes a first motor 21, a threaded rod 22, a sleeve plate 23, a connecting plate 24, a sleeve fastener 25, a mounting plate 26, a second motor 27, a slider 28 and a slide rail 29. The first motor 21 is fixedly installed on the inner wall of the box 1, and the output end of the first motor 21 is fixedly connected to one end of the threaded rod 22, and the other end of the threaded rod 22 is rotatably connected to the other inner wall of the box 1. A group of sleeve plates 23 are threadedly connected to the threaded rod 22, and a group of connecting plates 24 are fixedly connected to the lower end of the sleeve plate 23, and a group of sleeve fasteners 25 are slidably connected to the connecting plate 24. 5. The sleeve 25 is threadedly connected to another group of threaded rods 22. One end of the threaded rods 22 is rotatably connected to the output shaft of the slider 28. The slider 28 is fixedly mounted on one side of the mounting plate 26. The mounting plate 26 is fixedly connected to the connecting plate 24. A group of sliders 28 are installed at the bottom of the second motor 27. The sliders 28 are slidably connected to the inside of the slide rails 29. The slide rails 29 are fixedly mounted on the inner side wall of the box body 1. A group of hydraulic rods 17 are fixedly mounted on the lower end of the sleeve 25. A group of connecting blocks 18 are fixedly mounted on the output shaft of the hydraulic rods 17. A plurality of groups of rubber droppers 19 are fixedly mounted on the lower end of the connecting blocks 18. A group of box doors 12 are fixedly installed on one side of the box body 1, a group of sliding bases 13 are slidably connected inside the box body 1, a group of sample placement seats 14 are slidably installed inside the box body 1, two groups of first slides 15 are slidably connected inside the box body 1, and two groups of second slides 16 are slidably connected inside the box body 1. The sliding base 13 is located between the sample placement seat 14 and a group of first slides 15, and the second slides 16 are located on one side of the first slide 15.

[0026] (3) The first motor 21 inside the moving component 2 of the present invention can drive the threaded rod 22 to rotate, thereby driving the sleeve plate 23 and the parts installed on the sleeve plate 23 to move left and right. While the connecting plate 24 moves, it will drive the slider 28 to slide in the slide rail 29. A group of threaded rods 22 is also fixedly installed at the output end of the second motor 27. This group of threaded rods 22 pushes the sleeve 25 to move forward and backward, thereby driving the rubber-tipped dropper 19 to move forward and backward and left and right to absorb different liquids.

[0027] Working principle: first open the box door 12, pull out the sliding base 13, the sample placement seat 14, the first slide 15 and the second slide 16 respectively, place the collected samples inside the sample placement seat 14, place the cleaned purification component 3 inside the sliding base 13, pour the reagent into the test tube on the first slide 15, and then add the corresponding liquid to the corresponding cleaning component 4, the first two groups are cleaning liquid, the middle two groups are alcohol, and the last two groups are clean water, then start the heating wire 52 inside the drying component 5 to start preheating, and after filling is completed, reset the sliding base 13, the sample placement seat 14, the first slide 15 and the second slide 16, and close the box door 12 at the same time, start the box body 1, and the first motor 21 inside the moving component 2 can drive the screw The threaded rod 22 rotates, thereby driving the sleeve plate 23 and the parts installed on the sleeve plate 23 to move left and right. While the connecting plate 24 moves, it will drive the slider 28 to slide in the slide rail 29, and a group of threaded rods 22 are also fixedly installed on the output end of the second motor 27. This group of threaded rods 22 pushes the sleeve 25 to move forward and backward, thereby driving the rubber head dropper 19 to move forward and backward and left and right to absorb different liquids. The moving component 2 will first drive the rubber head dropper 19 to move above the sample placement seat 14, and under the drive of the hydraulic rod 17, it will extend downward to absorb the sample placed on the sample placement seat 14, and then move to the top of the purification component 3 to drip the sample into the interior of the mixing cylinder 34, and then the moving component 2 drives the rubber head dropper 19 to move to the top of the first slide plate 15 to absorb its The reagents stored inside, each group of samples corresponds to a group of reagent tubes, the moving component 2 will drive the rubber-tipped dropper 19 to put the absorbed reagents into the corresponding purification component 3, the conical filter plate 35 inside the purification component 3 can filter out impurities in the sample, after the reagent enters the interior of the purification component 3, the third motor 32 will start accordingly, the third motor 32 will drive the disc 33 and the mixing barrel 34 to rotate, and the side wall of the conical filter plate 35 is fixedly connected to the mixing tube 31, and is slidably connected to the outer wall of the mixing barrel 34, so the conical filter plate 35 is in a stationary state, at this time the stirring rod 36 will continuously stir the sample and reagent mixture to make it more evenly mixed, and the leakage hole provided on the conical filter plate 35 is a conical leakage hole, after the sample enters the interior of the mixing barrel 34 The substances in the sample begin to react with the reagents, and their volume will increase. When pouring out the sample, these impurities will be blocked by the conical filter plate 35 inside the mixing tube 34, thereby achieving a purification effect. When cleaning it later, it is only necessary to add cleaning liquid, and then open the valve in the outlet on one side of the mixing tube 31 to rinse it. At the same time, the moving component 2 will drive the rubber head dropper 19 to the upper end of the first two groups of cleaning components 4, and corresponding to the position of the cleaning tube 44, the hydraulic rod 17 drives the rubber head dropper 19 to move downward, and the rubber head dropper 19 enters the interior of the cleaning tube 44, and the ultrasonic vibrator 45 is started. At this time, the pump inside the rubber head dropper 19 will continuously draw the cleaning liquid inside the cleaning tube 44 into the rubber head dropper 19, and then release it. In the process of repeated suction,The ultrasonic vibrator 45 will drive the cleaning liquid to vibrate continuously, so as to clean the inner wall of the rubber-tipped dropper 19. After the cleaning liquid inside the cleaning tube 44 is used many times, it will be sucked into the interior by the pump 43 on the side wall of the water tank 42, which is convenient for subsequent cleaning. At this time, the pump 43 on the side wall of the fixed box 41 will pour new cleaning liquid into the interior of the cleaning tube 44. After the cleaning of the rubber-tipped dropper 19 is completed, the hydraulic rod 17 drives the rubber-tipped dropper 19 to reset, and then drives it to the upper end of the middle group of cleaning components 4, and repeats the above operation. The liquid inside this group is alcohol, which can sterilize and disinfect the inner and outer walls of the rubber-tipped dropper 19 to prevent subsequent cross-contamination of samples. Finally, the mobile component 2 is driven to the rear Repeat the above operation above the two cleaning components 4. The liquid in this cleaning component 4 is clean water, which can wash away the alcohol adhering to the inner wall of the rubber head dropper 19. After completing the cleaning work, the moving component 2 will drive the rubber head dropper 19 to the top of the drying component 5, and then the hydraulic rod 17 drives the rubber head dropper 19 into the interior of the drying tube 53. At this time, the electric push rod 56 contracts and drives the moving plate 57 to move, thereby opening the gap opened on the partition 55. The fan 54 starts and blows the heat generated by the heating wire 52 to the rubber head dropper 19. The hot air will enter the interior of the rubber head dropper 19, thereby playing a drying role and preventing water droplets from affecting the subsequent sample detection results.

[0028] The above shows and describes the basic principles, main features and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The above embodiments and descriptions are only for explaining the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention. The scope of protection claimed by the present invention.

Claims

1. An automatic nucleic acid extraction instrument with purification function, characterized in that: comprising a box body (1); A cleaning assembly (4), wherein a plurality of groups of the cleaning assemblies (4) are installed inside the box body (1), wherein the interior of the cleaning assembly (4) comprises a fixed box (41), a water tank (42), a pump (43), a cleaning pipe (44), an ultrasonic vibrator (45), a flat pipe (46), a hose (47) and a first installation box (48), wherein the liquid inside the first two groups of the cleaning assemblies (4) is cleaning liquid, the liquid inside the middle two groups of the cleaning assemblies (4) is alcohol, and the liquid inside the last two groups of the cleaning assemblies (4) is clean water; Cleaning pipes (44), a plurality of groups of the cleaning pipes (44) being fixedly mounted inside the first mounting box (48); An ultrasonic vibrator (45), wherein the ultrasonic vibrator (45) is fixedly mounted on the lower end of the cleaning tube (44), and a probe of the ultrasonic vibrator (45) is located inside the cleaning tube (44); A drying assembly (5), wherein a plurality of groups of the drying assemblies (5) are installed inside the housing (1), and the interior of the drying assembly (5) comprises a second installation box (51), a heating wire (52), a drying tube (53), a fan (54), a partition (55), an electric push rod (56), and a moving plate (57); A heating wire (52), wherein the heating wire (52) is fixedly installed inside the second installation box (51); Drying tubes (53), wherein a plurality of groups of the drying tubes (53) are fixedly installed inside the second installation box (51) and are located below the heating wire (52); A fan (54), wherein the fan (54) is fixedly mounted at the inner bottom end of the drying tube (53).

2. The automatic nucleic acid extractor with purification function according to claim 1, characterized in that: The first installation box (48) is installed on one of the second slide plates (16); a group of fixed boxes (41) is fixedly installed inside the first installation box (48); a group of pumps (43) is fixedly installed on one side of the fixed box (41); the pumps (43) are connected to cleaning pipes (44) via pipelines; and a plurality of groups of cleaning pipes (44) are fixedly connected via flat pipes (46).

3. The automatic nucleic acid extractor with purification function according to claim 2, characterized in that: A group of water tanks (42) are also fixedly installed inside the first installation box (48), and a group of pumps (43) are fixedly installed on one side of the water tanks (42). The pumps (43) are fixedly connected to one group of cleaning pipes (44) via a hose (47), and one end of the hose (47) is located at the bottom end of the cleaning pipe (44).

4. The automatic nucleic acid extractor with purification function according to claim 1, characterized in that: The second installation box (51) is installed on another set of second slide plates (16). The second installation box (51) is made of an ethylene foam board. A set of partitions (55) are fixedly installed inside the second installation box (51). The partitions (55) are located between the drying tube (53) and the heating wire (52). The partitions (55) are also made of an ethylene foam board. Through holes are provided on both the upper and lower sides of the partitions (55).

5. The automatic nucleic acid extractor with purification function according to claim 4, characterized in that: A plurality of groups of electric push rods (56) are fixedly installed inside the partition (55), and output shafts of the electric push rods (56) are fixedly connected to movable plates (57), wherein one group of the movable plates (57) is slidably connected to the inner upper end of the partition (55), and another group of the movable plates (57) is slidably connected to the inner lower end of the partition (55).

6. The automatic nucleic acid extractor with purification function according to claim 1, characterized in that: The housing (1) is slidably mounted with a set of sliding bases (13), on which a plurality of purification components (3) are mounted, wherein the interior of the purification components (3) comprises a mixing tube (31), a third motor (32), a disc (33), a mixing cylinder (34), a conical filter plate (35) and a stirring rod (36), and the interior of the mixing tube (31) is fixedly mounted with a set of third motors (32).

7. The automatic nucleic acid extractor with purification function according to claim 6, characterized in that: The output shaft of the third motor (32) is fixedly connected to a disc (33), and the disc (33) is rotatably connected to the inside of the mixing tube (31). A group of mixing barrels (34) is fixedly mounted on the upper end of the mixing tube (31), and the mixing barrels (34) are rotatably connected to the inside of the mixing tube (31). The inner wall of the mixing barrel (34) is rotatably connected to the outer wall of a conical filter plate (35). The conical filter plate (35) and the mixing tube (31) are fixedly connected. The mixing barrel (34) is divided into two sections. A plurality of stirring rods (36) are fixedly mounted on the lower end of the conical filter plate (35), and another group of conical sieve plates are fixedly mounted on the upper end of the conical filter plate (35), and the sieve holes of the sieve plates are different from those of the conical filter plate (35).

8. The automatic nucleic acid extraction instrument with purification function according to claim 1, characterized in that: A group of moving components (2) is installed inside the box (1), and the moving components (2) include a first motor (21), a threaded rod (22), a sleeve plate (23), a connecting plate (24), a sleeve (25), a mounting plate (26), a second motor (27), a slider (28) and a slide rail (29). The first motor (21) is fixedly installed on the inner wall of the box (1), and the output end of the first motor (21) is fixedly connected to one end of the threaded rod (22), and the other end of the threaded rod (22) is rotatably connected to the other inner wall of the box (1).

9. The automatic nucleic acid extractor with purification function according to claim 8, characterized in that: A set of sleeve plates (23) are threadedly connected to the threaded rod (22), a set of connecting plates (24) are fixedly connected to the lower end of the sleeve plates (23), a set of sleeve fasteners (25) are slidably connected to the connecting plates (24), and the sleeve fasteners (25) are threadedly connected to another set of threaded rods (22), one end of the threaded rods (22) of this set is rotatably connected to the output shaft of a slider (28), the slider (28) is fixedly mounted on one side of a mounting plate (26), the mounting plate (26) is fixedly connected to the connecting plate (24), a set of sliders (28) are mounted at the bottom of the second motor (27), the sliders (28) are slidably connected to the inside of a slide rail (29), and the slide rail (29) is fixedly mounted on the inner side wall of the box body (1).

10. The automatic nucleic acid extractor with purification function according to claim 9, characterized in that: A group of hydraulic rods (17) are fixedly mounted on the lower end of the sleeve (25), a group of connecting blocks (18) are fixedly mounted on the output shaft of the hydraulic rods (17), and a plurality of groups of rubber-tipped drip tubes (19) are fixedly mounted on the lower end of the connecting blocks (18).

11. The automatic nucleic acid extractor with purification function according to claim 1, characterized in that: A set of box doors (12) are fixedly mounted on one side of the box body (1); a set of sliding bases (13) are slidably connected to the inside of the box body (1); a set of sample placement seats (14) are slidably mounted to the inside of the box body (1); two sets of first slides (15) are slidably connected to the inside of the box body (1); two sets of second slides (16) are slidably connected to the inside of the box body (1); the sliding base (13) is located between the sample placement seats (14) and a set of first slides (15); and the second slides (16) are located on one side of the first slides (15).

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