Device for fixing mouse through MRI (Magnetic Resonance Imaging)

Abstract

The invention belongs to the technical field of medical instruments, and particularly relates to a mouse fixing device for MRI (Magnetic Resonance Imaging), which mainly comprises a fixing base, the fixing base is provided with a first supporting plate and a second supporting plate which are spaced from each other, the first supporting plate is provided with a first connecting part, and the second supporting plate is provided with a second connecting part; the head fixing part is mounted on the head of the experimental mouse in advance; the head fixing part comprises a first connecting section, a second connecting section and an arc-shaped section, the arc-shaped section is located between the first connecting section and the second connecting section, the first connecting section is detachably connected with the first connecting section, the second connecting section is detachably connected with the second connecting section, and the inner side face of the arc-shaped section is the face connected with the head of an experimental mouse; and the restraining piece is used for restraining the trunk of the experimental mouse provided with the head fixing piece, and the restraining piece is removably placed between the first supporting plate and the second supporting plate.

Description

Technical Field

[0001] The invention belongs to the technical field of medical devices, and in particular relates to a device for fixing mice in MRI. Background Art

[0002] Magnetic Resonance Imaging (MRI) system is a type of imaging equipment used for medical examinations that uses the nuclear magnetic resonance phenomenon. MRI is a biological magnetic spin imaging technology that uses the characteristics of atomic nucleus spin motion to generate signals after being excited by radio frequency pulses in an external magnetic field. The signals are detected by detectors and input into computers, and the images are displayed on the screen after being processed and converted by computers.

[0003] In mouse experiments, in order to study the functional activities of the mouse brain or the functional activities of the mouse brain under drug intervention, the mouse skull is also scanned under nuclear magnetic resonance to obtain the mouse brain tissue image. In the current experimental process, anesthetics are usually used to perform preliminary anesthesia on the experimental mice. After they lose the ability to move, the heads of the experimental mice are fixed for scanning. However, the problem is that under the use of anesthetics, the functional activities of the experimental mice will be suppressed, and the physiological signals generated will be reduced, resulting in a large deviation between the final obtained brain functional activities and physiological signal information of the experimental mice and the awake experimental mice. In particular, under drug intervention, anesthesia of the experimental mice will increase the deviation of the test results, and thus the brain functional activities of the experimental mice in the normal physiological state cannot be obtained; and when the experimental mice are in the awake state and the head is scanned, because the head of the experimental mice is fixed, the experimental mice will enter a state of agitation, and their trunk and limbs will continue to struggle, causing the head to shift, which in turn causes artifacts in the scanned image information, affecting the brain research of the experimental mice.

[0004] In view of the above problems, the present invention provides a device for fixing mice in MRI. Summary of the invention

[0005] In order to overcome the problems raised in the background technology, the present invention adopts the following technical solutions:

[0006] A device for fixing mice for MRI, comprising:

[0007] A fixed base, the fixed base having a first supporting plate and a second supporting plate spaced apart from each other, wherein the first supporting plate has a first connecting portion, and the second supporting plate has a second connecting portion;

[0008] A head fixing piece, pre-installed on the head of the experimental mouse; the head fixing piece comprises a first connecting section, a second connecting section and an arc section, the arc section is located between the first connecting section and the second connecting section, the first connecting section is detachably connected to the first connecting section, the second connecting section is detachably connected to the second connecting section, wherein the inner side surface of the arc section is a side engaged with the head of the experimental mouse;

[0009] The restraint is used to restrain the trunk of the experimental mouse equipped with the head fixing device, and the restraint is removably placed between the first supporting plate and the second supporting plate.

[0010] In some embodiments of the present application, the first connection portion is located on one side of the first support plate in the length direction of the first support plate, wherein an end of the first connection portion away from the first support plate is inclined toward the second support plate.

[0011] Further, the top end surface of the first supporting plate is located above the first connecting portion in a height extension direction of the first supporting plate.

[0012] In some embodiments of the present application, the first support plate and the second support plate are mirror images of each other, the first connection portion and the second connection portion are also mirror images of each other, and there is a distance between the second connection portion and the first connection portion.

[0013] In some embodiments of the present application, the first connecting portion has a threaded hole, and the first connecting section has a mounting hole;

[0014] The device for fixing mice for MRI also includes: a bolt, wherein the bolt is screwed into the threaded hole after passing through the mounting hole until one end of the bolt abuts against the outer wall of the first connecting section, thereby forming a connection relationship between the first connecting section and the first mounting portion.

[0015] In some embodiments of the present application, it also includes: an abutment member, which is detachably connected to the first support plate and the second support plate, wherein when the restraint member is placed between the first support plate and the second support plate, the abutment member abuts against the outer wall of the restraint member.

[0016] Further, the abutment member comprises:

[0017] Crossbar;

[0018] A first connecting arm and a second connecting arm, wherein the first connecting arm and the second connecting arm are located on one side of the crossbar, and the first connecting arm and the second connecting arm are arranged in a mirror image with each other.

[0019] In some embodiments of the present application, the restraining member is cylindrical, and an insertion opening is opened on the outer wall of the restraining member toward the inner wall of the restraining member, wherein the insertion opening is constructed so that the width of the insertion opening can increase when subjected to force.

[0020] Furthermore, the restraining member includes a main body and a retracted end, wherein a diameter of the retracted end is smaller than an inner diameter of the main body.

[0021] Furthermore, the restraint also has a fixing belt and a fixing pin, wherein one end of the fixing belt is connected to the outer wall of the restraint and is located on one side of the insertion port, and the fixing pin is configured on the outer wall of the restraint and is located on the other side of the insertion port, and the fixing belt and the fixing pin are detachably connected.

[0022] Beneficial effects of the present invention:

[0023] By setting a fixed base, a head fixing piece and a restraining piece, when in use, firstly, the arc section of the head fixing piece is fixed to the head of the experimental mouse through minimally invasive surgery. After the fixation is completed, the torso of the experimental mouse in a conscious state is placed in the restraining piece, and then the head restraining piece is connected to the first connecting part and the second connecting part, so as to fix the head of the experimental mouse in a conscious state, and the restraining piece restrains the limbs and torso of the experimental mouse, thereby achieving the effect of all-round fixation of the mouse, avoiding interference of the scanned image information due to the struggle of the experimental mouse during the nuclear magnetic resonance scanning of the head of the experimental mouse; and avoiding anesthesia of the experimental mouse. When studying the brain function activities of the mouse under drug intervention, it can avoid the use of different types of drugs on the experimental mouse at the same time, thereby avoiding deviation of the test results. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 It is a schematic diagram of the overall structure of the present invention;

[0025] Figure 2 It is a schematic diagram of the structure of the first supporting plate and the second supporting plate of the present invention;

[0026] Figure 3 It is a schematic diagram of the structure of the first connecting part and the second connecting part of the present invention;

[0027] Figure 4 This is a schematic diagram of the restraining member of the present invention being located between the first supporting plate and the second supporting plate;

[0028] Figure 5 It is a schematic diagram of the structure of the head fixing part of the present invention;

[0029] Figure 6 It is a schematic diagram of the positional relationship between the head fixing parts of the restraining part of the present invention;

[0030] Figure 7 It is a schematic diagram of the structure of the restraining member of the present invention;

[0031] Figure 8 It is a schematic diagram of the positional relationship between the abutment member and the restraining member of the present invention;

[0032] Fig. 9 It is a schematic diagram of the structure of the abutment member of the present invention;

[0033] In the figure, 1, fixed base; 11, first supporting plate; 111, first connecting part; 1111, threaded hole; 12, second supporting plate; 121, second connecting part; 2, head fixing member; 21, first connecting section; 211, mounting hole; 22, second connecting section; 23, arc section; 231, circular hole; 3, restraining member; 31, fixing belt; 32, fixing pin; 33, insertion port; 4, abutting member; 41, cross bar; 42, first connecting arm; 43, second connecting arm. DETAILED DESCRIPTION

[0034] The technical solutions in the embodiments of the present invention are described clearly and completely below through specific embodiments. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Those skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. The present invention can also be implemented or applied through other different specific implementation methods. In the absence of conflict, the following embodiments and features in the embodiments can be combined with each other. Based on the embodiments in the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0035] Figure 1 —5 shows the main technical content of this embodiment. This specific embodiment provides a device for fixing mice for MRI, which includes:

[0036] A fixed base 1, the fixed base 1 has a first support plate 11 and a second support plate 12 which are spaced apart from each other, wherein the first support plate 11 has a first connecting portion 111, and the second support plate 12 has a second connecting portion 121;

[0037] The head fixing member 2 is pre-installed on the head of the experimental mouse; the head fixing member 2 includes a first connecting segment 21, a second connecting segment 22 and an arc segment 23, the arc segment 23 is located between the first connecting segment 21 and the second connecting segment 22, the first connecting segment 21 is detachably connected to the first connecting portion 111, and the second connecting segment 22 is detachably connected to the second connecting portion 121, wherein the inner side surface of the arc segment 23 is a side engaged with the head of the experimental mouse;

[0038] The restraint member 3 is used to restrain the trunk of the experimental mouse installed with the head fixing member 2 . The restraint member 3 is removably placed between the first supporting plate 11 and the second supporting plate 12 .

[0039] First of all, it should be explained that during the experiment, the experimental mouse was always in a conscious state. When the device was used, a minimally invasive surgery was first performed on the head of the experimental mouse to lift the scalp of the experimental mouse, and then the arc segment 23 of the head fixture 2 was attached to the exposed position of the skull of the experimental mouse, and the arc segment 23 of the head fixture 2 was fixed to the head of the experimental mouse using dental cement. After the fixation was completed, the trunk of the experimental mouse was placed in the restraint 3, and the experimental mouse and the restraint 3 were placed between the first support plate 11 and the second support plate 12, and the head fixture 2 was connected to the first connecting portion 111 to fix the experimental mouse; the fixed base 1 was installed on the nuclear magnetic resonance instrument, and then the radio frequency coil was covered on the head of the experimental mouse to perform a nuclear magnetic resonance scan on the head of the experimental mouse.

[0040] refer to Figure 1 Furthermore, the fixed base 1 also includes: a first mounting portion and a second mounting portion, wherein the first mounting portion is used to connect to the nuclear magnetic resonance instrument, and the second mounting portion is used to connect to the radio frequency coil of the nuclear magnetic resonance instrument; more specifically, the first mounting portion includes a plurality of first connecting shafts arranged at one end of the fixed base 1, wherein the plurality of first connecting shafts extend in a direction away from the first supporting plate 11 and the second supporting plate 12 in the length extension direction of the fixed base 1; when in use, the fixed base 1 is mounted on the guide rail of the nuclear magnetic resonance instrument through the plurality of first connecting shafts, so that when in use, the fixed base 1 can enter the nuclear magnetic resonance instrument with the movement of the guide rail of the nuclear magnetic resonance instrument, so as to perform a nuclear magnetic scan on the head of the experimental mouse.

[0041] refer to Figure 1 There are three first connecting shafts, and two of them are mirror-imaged, and the other first connecting shaft is located below the two first connecting shafts.

[0042] The second mounting portion includes: a first connecting protrusion and a second connecting protrusion; wherein, the fixed base 1 has a placement end surface, the first supporting plate 11 and the second supporting plate 12 are both located on the placement end surface, the first connecting protrusion and the second connecting protrusion are located on the placement end surface, and further, the first connecting protrusion and the second connecting protrusion are mirror-imaged to each other on the placement end surface, and there is a spacing between the first connecting protrusion and the second connecting protrusion, wherein the first connecting protrusion and the second connecting protrusion both have a second connecting axis, and the second connecting axis is perpendicular to the placement end surface. When in use, after the trunk and head of the experimental mouse are restrained, the radio frequency coil of the nuclear magnetic resonance instrument is connected to the first connecting protrusion and the second connecting protrusion through the two second connecting axes. At this time, the head of the experimental mouse is located below the radio frequency coil.

[0043] refer to Figure 1 —4. In this embodiment, the first connecting portion 111 is located on one side of the first supporting plate 11 in the length direction of the first supporting plate 11, wherein one end of the first connecting portion 111 away from the first supporting plate 11 is inclined toward the second supporting plate 12. Under this arrangement, the width of the space where the trunk of the experimental mouse is located is greater than the width of the space where the head of the experimental mouse is located, so that after the head fixing member 2 is connected to the first connecting portion 111, the head of the experimental mouse can be further constrained in the width direction of the fixed base 1, thereby further reducing the activity space of the head of the experimental mouse, thereby On the basis of the head fixing part 2, the restraining effect on the experimental mouse is enhanced; preferably, the top end surface of the first supporting plate 11 is located above the first connecting part 111 in the height extension direction of the first supporting plate 11. Under this arrangement, a height difference is formed between the first supporting plate 11 and the first connecting part 111, so that after the head fixing part 2 is connected to the first mounting part, the lower neck part of the mouse is close to the placement end surface, thereby realizing the restraint of the experimental mouse's head in the longitudinal direction, and preventing the experimental mouse's head from being suspended under the action of the head fixing part 2.

[0044] refer to Figure 4 In this embodiment, the first support plate 11 and the second support plate 12 are mirror images of each other; specifically, the second connection portion 121 and the first connection portion 111 are also mirror images, and there is a distance between the second connection portion 121 and the first connection portion 111. When in use, the head fixing piece 2 fixed on the head of the experimental mouse is connected to the first connection portion 111 and the second connection portion 121, so as to compress and fix the head of the experimental mouse.

[0045] More specifically, the first connecting portion 111 and the first supporting plate 11, as well as the second connecting portion 121 and the second supporting plate 12 are integrally connected. Under this arrangement, it is convenient to manufacture the fixed base 1, the first supporting plate 11, the second supporting plate 12, the first connecting portion 111 and the second connecting portion 121. For example, during manufacturing, the fixed base 1, the first supporting plate 11, the second supporting plate 12, the first connecting portion 111 and the second connecting portion 121 are printed as a whole through 3D printing, thereby reducing the manufacturing difficulty and manufacturing cost of the device.

[0046] As an alternative (not shown), the first connecting portion 111 and the second connecting portion 121 are both cylindrical shafts, wherein the two cylindrical shafts are both arranged on the placement end surface of the fixed base 1, and the two cylindrical shafts are mirrored to each other. In this arrangement, the first connecting portion 111 and the first supporting plate 11 are spaced apart, and the second connecting portion 121 and the second supporting plate 12 are also spaced apart. When in use, the head fixing member 2 is connected to the two cylindrical shafts. At this time, the head of the experimental mouse is fixed between the two cylindrical shafts, and the head of the experimental mouse is also in contact with the placement end surface under the action of the head fixing member 2.

[0047] refer to Figure 4 —5. In the present embodiment, the first connecting section 21, the second connecting section 22 and the arc section 23 included in the head fixing part 2 are integrally connected. Specifically, the arc section 23 is provided with a circular hole 231. When in use, the inner side surface of the arc section 23 is engaged with the head of the experimental mouse. Dental cement can enter through the circular hole 231 to bond the head of the experimental mouse to the arc section 23. After the dental cement solidifies, the head fixing part 2 is fixed to the head of the experimental mouse.

[0048] More specifically, the head fixing piece 2 is made of plastic. During use, when the experimenter applies force to the first connecting portion 111 and the second connecting portion 121 of the head fixing piece 2, the first connecting portion 111 and the second connecting portion 121 can approach each other. At this time, the curvature of the arc segment 23 also changes accordingly. Then, the deformation of the arc segment 23 can also play a role of clamping the heads of experimental mice of different sizes, thereby preventing the heads of the experimental mice from shaking during the experiment.

[0049] Preferably, the head fixing member 2 is made of one of polyamide, polylactic acid, ABS resin and photosensitive resin.

[0050] refer to Figure 4—5. In this embodiment, how to connect the first connecting section 21 and the first connecting part 111 and the second connecting section 22 and the second connecting part 121 is explained. Referring to the figure, the first connecting part 111 has a threaded hole 1111, and the first connecting section 21 has a mounting hole 211. When connecting the first connecting section 21 and the first connecting part 111, a bolt is used. After passing through the mounting hole 211, it is screwed into the threaded hole 1111 until one end of the bolt is against the outer wall of the first connecting section 21, so that the first connecting section 21 and the first mounting part are connected. Similarly, the connection method between the second connecting section 22 and the second connecting part 121 is the same as that of the first connecting section 21. A connection method between a connecting section 21 and a first connecting section 111, whereby, when in use, the head fixing piece 2 fixes the head of the experimental mouse; preferably, the mounting hole 211 is an oblong hole 231. When in use, when the curvature of the arc segment 23 does not fit the surface curve of the head of the experimental mouse, the first connecting section 21 and the second connecting section 22 can be brought close to each other to facilitate the inner side wall of the arc segment 23 to fit the curve of the head of the experimental mouse, thereby increasing the fixing force on the head of the experimental mouse, and allowing the bolt to always be screwed into the threaded hole 1111 after passing through the mounting hole 211, so as to realize the restraint of the heads of experimental mice of different sizes.

[0051] refer to Figure 4 —8. In the present embodiment, it also includes: an abutment member 4, which is detachably connected to the first support plate 11 and the second support plate 12, wherein when the restraint member 3 is placed between the first support plate 11 and the second support plate 12, the abutment member 4 abuts against the outer wall of the restraint member 3. Under this arrangement, after the restraint member 3 restrains the trunk of the experimental mouse, it will not shake between the first support plate 11 and the second support plate 12, thereby avoiding displacement of the head due to the struggle of the trunk and limbs of the experimental mouse, and avoiding artifacts in the scanned image information caused by the movement of the mouse's head.

[0052] Specifically, the abutment 4 includes: a cross bar 41, a first connecting arm 42 and a second connecting arm 43, the first connecting arm 42 and the second connecting arm 43 are located on one side of the cross bar 41, and the first connecting arm 42 and the second connecting arm 43 are mirror images of each other; when in use, the first connecting arm 42 is connected to the first supporting plate 11, and the second connecting arm 43 is connected to the second supporting plate 12. At this time, the cross bar 41 is located above the constraint 3, and one side of the cross bar 41 abuts against the outer wall of the constraint 3, thereby forming a connection relationship; more specifically, the first supporting plate 11 and the second supporting plate 12 both have through holes, and the first connecting arm 42 and the second connecting arm 43 have fixing holes. Preferably, the fixing holes are threaded holes 1111. When in use, bolts are used to pass through the through holes and then screwed into the threaded holes 1111, so as to connect the first connecting arm 42 to the first supporting plate 11, and similarly, the second connecting arm 43 to the second supporting plate 12 is connected by using bolts; thereby, the abutment 4 fixes the constraint 3.

[0053] More preferably, a slot is provided on the top end surface of the first supporting plate 11 and the second supporting plate 12 in the direction of the placement end surface of the fixed base 1 , wherein the cross bar 41 can be embedded in the slot.

[0054] More preferably, the first connecting arm 42 and the second connecting arm 43 are both located between the first supporting plate 11 and the second supporting plate 12 , and one side of the first connecting arm 42 is in contact with the first supporting plate 11 , and one side of the second connecting arm 43 is in contact with the second supporting plate 12 .

[0055] As an alternative (not shown), the first support plate 11 and the second support plate 12 are both provided with threaded holes 1111. After the restraint member 3 is placed between the first support plate 11 and the second support plate 12, a bolt is screwed into each of the two threaded holes 1111, and one end of the two bolts is abutted against the outer wall of the restraint member 3, so that the restraint member 3 is fixed between the first support plate 11 and the second support plate 12, so that the restraint member 3 does not shake.

[0056] refer to Figure 1 and Figure 7—9. In the present embodiment, the restraint 3 is cylindrical, and an insertion opening 33 is opened on the outer wall of the restraint 3 toward the inner wall of the restraint 3, wherein the insertion opening 33 is constructed so that when subjected to force, the width of the insertion opening 33 can be increased. When in use, the experimenter holds the experimental mouse with one hand and applies force to both sides of the insertion opening 33 with the other hand to expand the insertion opening 33, and then places the experimental mouse in the restraint 3, and extends the head of the experimental mouse from the port at one end of the restraint 3. At this time, the trunk and limbs of the experimental mouse are restrained, and then the restraint 3 loaded with the experimental mouse is placed between the first support plate 11 and the second support plate 12, and is connected to the first connecting portion 111 and the second connecting portion 121 through the head fixing member 2, so as to complete the fixation of the experimental mouse in the awake state.

[0057] More preferably, the restraint 3 includes a main body and a retracted end, wherein the diameter of the retracted end is smaller than the inner diameter of the main body, and after the trunk of the experimental mouse is placed on the main body, the neck of the experimental mouse is located in the retracted end, and the retracted end fits against the body surface of the experimental mouse.

[0058] More specifically, the restraint 3 also has a plurality of ventilation holes, wherein the plurality of ventilation holes are opened from the outer wall of the restraint 3 toward the inner wall of the restraint 3. Under this setting, the circulation rate of air in the restraint 3 is enhanced, thereby lowering the body temperature of the experimental mice and preventing the experimental mice from sweating on their body surface during the experiment.

[0059] refer to Figure 7More specifically, the restraint 3 also has a fixing belt 31 and a fixing pin 32, wherein one end of the fixing belt 31 is connected to the outer wall of the restraint 3 and is located on one side of the insertion opening 33, and the fixing pin 32 is arranged on the outer wall of the restraint 3 and is located on the other side of the insertion opening 33, and the fixing belt 31 and the fixing pin 32 are detachably connected. When in use, after placing the experimental mouse in the restraint 3, by connecting the fixing belt 31 and the fixing pin 32, the insertion opening 33 will not expand due to the struggle of the experimental mouse, thereby making the restraint 3 always maintain the restraint force on the experimental mouse; further, a plurality of round holes 231 are set through the fixing belt 31, wherein the plurality of round holes 231 are arranged along The length extension direction of the fixing belt 31 is arranged in an array, and the end of the fixing pin 32 away from the restraint 3 is set as a ball head, and the diameter of the ball head is larger than the diameter of the circular hole 231. After the experimental mouse is placed in the restraint 3, the fixing belt 31 is pulled to tighten the insertion port 33. At this time, each circular opening on the fixing belt 31 is deformed, and then the fixing belt 31 is moved closer to the fixing pin 32, so that one end of the fixing pin 32 is inserted into the applicable circular hole 231 to form a connection relationship, thereby making the two sides of the insertion port 33 always keep close to each other, so as to restrain the limbs and trunk of the experimental mouse and avoid violent struggle of the trunk and limbs of the experimental mouse during the experiment.

[0060] As an alternative (not shown), the restraint 3 includes: a placement seat, a first curved wall and a second curved wall; the placement seat is a rectangular body, the first curved wall and the second curved wall are arranged on the same end face of the placement seat, and the first curved wall and the second curved wall are mirror-imaged to each other. When in use, the trunk of the experimental mouse is placed between the first curved wall and the second curved wall, and then the fixing belt 31 is connected to the fixing pin 32 so that the trunk and limbs of the experimental mouse are restrained in the restraint space formed by the first curved wall, the second curved wall and the placement seat, thereby restraining the mouse. Under this setting, after the restraint 3 is placed between the first support plate 11 and the second support plate 12, the placement seat increases the contact area between the restraint 3 and the placement end face, thereby further maintaining the stability of the restraint 3.

[0061] More specifically, the insertion port 33 is located between the first curved wall and the second curved wall. When in use, force can be applied to the placement seat to cause the placement seat to bend. At this time, the width of the insertion port 33 is expanded, thereby facilitating the placement of the experimental mouse between the first curved wall and the second curved wall.

[0062] Method of use of the present invention:

[0063] 1. Open the scalp of the experimental mouse through minimally invasive surgery to expose the skull of the experimental mouse, and then use dental cement to fix the arc section of the head fixture to the head of the experimental mouse;

[0064] 2. After the fixation is completed, the trunk of the experimental mouse in the awake state is placed in the restraint, and the experimental mouse and the restraint are placed between the first support plate and the second support plate, and the head fixing piece is connected to the first connecting part, so as to fix the experimental mouse;

[0065] 3. Install the fixed base on the MRI instrument, and then cover the head of the experimental mouse with the radio frequency coil to perform an MRI scan on the head of the experimental mouse.

[0066] The above embodiments are only used to understand the present invention. It should be noted that, for those skilled in the art, several improvements can be made to the present invention without departing from the principles of the present invention, and these improvements will also fall within the scope of protection of the claims of the present invention.

Claims

1. A device for fixing mice for MRI, characterized in that: It includes: A fixed base, the fixed base having a first supporting plate and a second supporting plate spaced apart from each other, wherein the first supporting plate has a first connecting portion, and the second supporting plate has a second connecting portion; A head fixing piece, pre-installed on the head of the experimental mouse; the head fixing piece comprises a first connecting section, a second connecting section and an arc section, the arc section is located between the first connecting section and the second connecting section, the first connecting section is detachably connected to the first connecting section, the second connecting section is detachably connected to the second connecting section, wherein the inner side surface of the arc section is a side engaged with the head of the experimental mouse; The restraint is used to restrain the trunk of the experimental mouse equipped with the head fixing device, and the restraint is removably placed between the first supporting plate and the second supporting plate.

2. The device for fixing mice for MRI according to claim 1, characterized in that: The first connection portion is located at one side of the first support plate in the length direction of the first support plate, wherein one end of the first connection portion away from the first support plate is inclined toward the second support plate.

3. The device for fixing mice for MRI according to claim 1, characterized in that: The top end surface of the first supporting plate is located above the first connecting portion in a height extension direction of the first supporting plate.

4. The device for fixing mice for MRI according to any one of claims 1 to 3, characterized in that: The first supporting plate and the second supporting plate are arranged in a mirror image with each other, the first connecting portion and the second connecting portion are also arranged in a mirror image with each other, and there is a distance between the second connecting portion and the first connecting portion.

5. The device for fixing mice for MRI according to claim 4, characterized in that: The first connecting portion has a threaded hole, and the first connecting section has a mounting hole; The device for fixing mice for MRI also includes: a bolt, wherein the bolt is screwed into the threaded hole after passing through the mounting hole until one end of the bolt abuts against the outer wall of the first connecting section, thereby forming a connection relationship between the first connecting section and the first mounting portion.

6. The device for fixing mice for MRI according to claim 1, characterized in that: Also includes: An abutment member, wherein the abutment member is detachably connected to the first support plate and the second support plate, wherein when the restraining member is placed between the first support plate and the second support plate, the abutment member abuts against an outer wall of the restraining member.

7. The device for fixing mice for MRI according to claim 6, characterized in that: The abutment member comprises: Crossbar; A first connecting arm and a second connecting arm, wherein the first connecting arm and the second connecting arm are located on one side of the crossbar, and the first connecting arm and the second connecting arm are mirror-imaged to each other.

8. The device for fixing mice for MRI according to claim 1, characterized in that: The restraining member is cylindrical, and an insertion opening is opened on the outer wall of the restraining member toward the inner wall of the restraining member, wherein the insertion opening is constructed so that the width of the insertion opening can be increased when a force is applied.

9. The device for fixing mice for MRI according to claim 8, characterized in that: The restraining member includes a main body and a retracted end, wherein a diameter of the retracted end is smaller than an inner diameter of the main body.

10. The device for fixing mice for MRI according to claim 8, characterized in that: The restraint also has a fixing belt and a fixing pin, wherein one end of the fixing belt is connected to the outer wall of the restraint and is located on one side of the insertion port, and the fixing pin is configured on the outer wall of the restraint and is located on the other side of the insertion port, and the fixing belt and the fixing pin are detachably connected.

Images