Contrast agent injection device and use method

Abstract

The invention discloses a contrast agent injection device and a use method, and relates to the technical field of contrast agent injection. According to the contrast agent injection device, the air cylinder pumps out part of normal saline through the injection piece, in addition, the injection piece is attached to the microfiltration membrane assembly, no matter how the flowing direction of the normal saline is, most bubbles can be gathered near the microfiltration membrane assembly in the flowing direction, and therefore the air cylinder can synchronously pump out the bubbles. Then the auxiliary cylinder is filled with normal saline mixed with gas at a high speed, the gas is mixed with the flowing normal saline again, and the steps are repeated to enable the gas to form microbubbles, so that the microbubble contrast agent is prepared, and the problems that when the microbubble contrast agent is prepared in the prior art, the gas and the normal saline are not mixed uniformly, and the stability is poor are solved. Although the bubbles can be uniform in size, the problem that the bubbles are too large possibly exists.

Description

Technical Field

[0001] The present invention relates to the technical field of contrast agent injection, and in particular to a contrast agent injection device and a use method thereof. Background Art

[0002] Contrast agents are substances used to enhance the contrast of medical images. They change the absorption, reflection or scattering characteristics of certain components in human tissues (such as blood vessels, organs, etc.) to imaging signals (such as X-rays, ultrasound, magnetic resonance signals, etc.), so that tissues and lesions that were originally difficult to distinguish can be clearly displayed on the image. According to the classification of material state, they can include liquid contrast agents, solid contrast agents and gas contrast agents.

[0003] The Chinese invention patent with announcement number CN108744113B discloses an automated synthetic contrast agent and injection device. By setting a structural connection between a first air pump, a second air pump, a first electromagnetic air valve, a second electromagnetic air valve and a first cylinder and a second cylinder, the traditional manually operated contrast agent injector is converted into an automated contrast agent injection device, solving the technical problems of insufficient contrast agent mixing times and poor microbubble stability; by realizing the automation and standardization of the examination, the mixing frequency and number of contrast agents can be accurately mastered, and at the same time, the size of the contrast agent microbubbles in the injector can be uniform and more stable, compensating for the influence of substandard frequency and insufficient number of times during manual operation, thereby improving the accuracy and repeatability of contrast examinations.

[0004] However, when preparing microbubble contrast agents in the above prior art, there is an uneven mixing of gas and physiological saline. Although the bubble size can be uniform, there may be a problem of bubbles being too large. Summary of the invention

[0005] In view of the deficiencies of the prior art, the present invention provides a contrast agent injection device and a method of use, which solves the problem of uneven mixing of gas and saline when preparing microbubble contrast agents in the prior art. Although uniform bubble size can be achieved, there may be a problem of bubbles being too large.

[0006] To achieve the above objectives, the present invention is implemented through the following technical solutions: a contrast agent injection device, comprising a syringe, the bottom of the surface of the syringe is connected to a liquid injection tube through a connecting valve, and the bottom of the surface of the syringe is also connected to a sampling tube through a connecting valve; the bottom end of the syringe is connected to a contrast agent classification outflow component, the contrast agent classification outflow component is used to classify and divert pure liquid contrast agent and solid-liquid mixed contrast agent, the top of the syringe is connected to two auxiliary cylinders through a diverter; the surface of the auxiliary cylinder is connected to a mixing injection component, the mixing injection component is used to mix additional materials into physiological saline to prepare contrast agent; The auxiliary cylinder comprises a reciprocating part and a receiving part, the mixed material injection assembly is connected to the receiving part, the bottom of the reciprocating part is movably connected to the top of the receiving part, two packaging rings are connected to the surface of the receiving part, the packaging rings are used to package the connection position between the reciprocating part and the receiving part, and the receiving part is connected to the diverter; a suction assembly is arranged inside the auxiliary cylinder, and an air pipe is connected to the surface of the injection cylinder through a connecting valve, and the air pipe and the suction assembly are used to make the physiological saline injected through the injection tube reciprocate in the injection tube and the auxiliary cylinder, so that the physiological saline is mixed with the additional material; the sampling tube is used to send the prepared contrast agent into the detection device, and determine whether the preparation is completed based on the detection result of the detection device. It also includes: a support frame and a cleaning cylinder, wherein the support frame is connected to a cleaning structure for cleaning the syringe, and when the cleaning structure cleans the syringe, the cleaning structure is connected to the receiving part through the cleaning cylinder; a limiting sleeve is movably sleeved on the surface of the syringe, and the limiting sleeve is fixedly connected to the support frame.

[0007] Furthermore, the contrast agent classification outflow component includes a solid-liquid mixed contrast agent outflow structure and a pure liquid contrast agent outflow structure, the syringe includes a columnar portion and an injection portion, the columnar portion is fixedly connected to the injection portion, and a first solenoid valve is fixedly connected to the outlet of the injection portion; the solid-liquid mixed contrast agent outflow structure is fixedly connected to the outside of the columnar portion, and the outlet of the solid-liquid mixed contrast agent outflow structure is fixedly connected to the outlet of the first solenoid valve; the pure liquid contrast agent outflow structure is movably arranged inside the columnar portion.

[0008] Furthermore, the solid-liquid mixed contrast agent outflow structure includes a first electrically controlled valve and an outflow piece, wherein the first electrically controlled valve is fixedly connected to the surface of the columnar portion, and one end of the outflow piece is fixedly connected to the position of the columnar portion corresponding to the first electrically controlled valve; the other end of the outflow piece is fixedly connected to a connecting pipe, and the surface of the connecting pipe is fixedly connected to a second electrically controlled valve, one end of the connecting pipe is fixedly connected to the outlet of the first solenoid valve, and the other end of the connecting pipe is fixedly connected to the second solenoid valve; the top of the outflow piece is fixedly connected to an exhaust valve, and the exhaust valve is used to connect to an external exhaust device.

[0009] Furthermore, the pure liquid contrast agent outflow structure includes a movable part, a surface of the movable part is provided with a hole groove, and a third electrically controlled valve is fixedly connected to the inside of the hole groove; the surface of the movable part is also provided with a placement groove, the inner side wall of the placement groove is movably connected to a guide column, one end of the guide column is fixedly connected to a hole groove plate, the surface of the hole groove plate is fixedly connected to a plug column, and the surface of the plug column is movably connected to the inner side wall of the hole groove; the bottom of the movable part is fixedly connected to a wireless charging battery module, the wireless charging battery module is fixedly connected to an electromagnet, and the electromagnet is connected to the guide column; the surface of the guide column is sleeved with a return spring, one end of the return spring is fixedly connected to the surface of the hole groove plate, and the other end of the return spring is fixedly connected to the surface of the movable part.

[0010] Furthermore, the pure liquid contrast agent outflow structure is arranged above the trachea, and the suction assembly includes a piston member and a threaded rod. The piston member is arranged above the mixture injection assembly, and one end of the threaded rod is movably connected to the piston member; the other end of the threaded rod movably passes through the top of the auxiliary cylinder and is threadedly connected to the first spur gear, the first spur gear is movably connected to the auxiliary cylinder through a bearing, the top of the auxiliary cylinder is connected to a second spur gear through a fixed plate, the second spur gear is fixedly connected to the rotating motor, and the first spur gear is meshed with the second spur gear; the piston member includes a piston column, a flexible connecting part and a lifting part, the piston column is fixedly connected to one end of the flexible connecting part, the other end of the flexible connecting part is fixedly connected to the lifting part, and the lifting part is movably connected to one end of the threaded rod.

[0011] Furthermore, the mixed material injection assembly includes an air cylinder and two injection structures, the two injection structures are respectively connected to two receiving parts, and an air intake valve is fixedly connected to the air cylinder; the injection structure includes a delivery pipe and two control valves connected to the delivery pipe, the end of the delivery pipe away from the control valve is connected to the air cylinder through an on-off valve, and the control valve is connected to the injection piece; two microfiltration membrane assemblies are fixedly connected inside one of the receiving parts, and the two injection pieces are located between the two microfiltration membrane assemblies; the surface of the delivery pipe is connected to the auxiliary pipe through a shut-off valve.

[0012] Furthermore, the injection piece includes an annular tube and an injection needle, the injection needle is fixedly connected to the annular tube, the injection needle penetrates into the interior of the receiving part, and the annular tube is fixedly connected to the surface of the receiving part.

[0013] Furthermore, the cleaning structure includes a liquid storage tank, which is fixedly installed on the top of the support frame, and a water pump is fixedly connected to one side of the liquid storage tank, and the water inlet end of the water pump is fixedly connected to a liquid inlet pipe; when the injection cylinder 1 is cleaned, the end of the liquid inlet pipe away from the water pump is connected to the connecting pipe through a sealing bearing; the interior of the liquid storage tank is fixedly connected to a driving motor, and the driving motor is transmission-connected to a threaded column through a gear box, and a movable plate is threadedly sleeved on the surface of the threaded column, and the surface of the movable plate is movably connected to the inner wall of the liquid storage tank, and the interior of the liquid storage tank is fixedly connected to a connecting column that movably passes through the movable plate; a liquid inlet valve and an exhaust valve are respectively provided on the top of the liquid storage tank, and a drain valve is also provided on the surface of the liquid storage tank.

[0014] Furthermore, the tops of the two reciprocating parts are movably connected to the connecting cover, the top of the connecting cover is provided with a through hole, the top of the cleaning cylinder is fixedly connected with a cleaning valve, and the size of the cleaning valve is adapted to the size of the through hole; the top of the connecting cover is fixedly connected with a centrifugal motor, the top of the centrifugal motor is fixedly connected with a mounting piece, the bottom of the liquid storage tank is provided with a liquid outlet valve, the bottom of the liquid storage tank is fixedly connected with a circular plate through a fixing column, the bottom of the circular plate is fixedly connected with an L-shaped plate, and the L-shaped plate is fixedly connected to the mounting piece through bolts; the circular plate is connected to the circular ring through a first connecting bearing, the circular ring is connected to the closing plate through a second connecting bearing, the closing plate is fixedly connected to the bottom of the liquid storage tank, a flushing valve is installed at the bottom of the circular ring, and when the injection cylinder is cleaned, the flushing valve is connected to the cleaning valve through a water pipe; the bottom of the circular ring is fixedly connected with a first connecting plate, the top of the connecting cover is fixedly connected with a second connecting plate, and the first connecting plate and the second connecting plate can be connected by screws.

[0015] A method for using a contrast agent injection device is applied to the above-mentioned contrast agent injection device, comprising the following steps: injecting physiological saline into the syringe through an injection tube, and a mixing injection component simultaneously extracting gas in the syringe, and stopping injection after the injection of physiological saline is completed; the suction component and the trachea are in action, and when the trachea injects gas into the syringe, the suction component moves upward to transfer the physiological saline to an auxiliary cylinder, and then the gas in the syringe is discharged through the trachea, and the suction component moves downward, and the physiological saline is transferred from the auxiliary cylinder to the syringe, so that the physiological saline flows back and forth; in the process of the reciprocating flow of the physiological saline, a mixture is injected into the auxiliary cylinder through the mixing injection component to mix the physiological saline with the mixture, wherein the mixture includes gas, radioactive raw materials and solid raw materials; after mixing for a period of time, the sampling tube sends part of the contrast agent into the detection device, and the detection device outputs the detection result. If the detection result is unqualified, the preparation is continued, and if the detection result is qualified, the preparation is stopped; the qualified contrast agent is output through the contrast agent classification outflow component; after the use of the contrast agent is finished, the syringe is cleaned by the cleaning structure.

[0016] The present invention has the following beneficial effects: (1) In the contrast agent injection device, the gas cylinder extracts part of the saline solution through the injection piece, and the injection piece is attached to the microfiltration membrane assembly. Regardless of the flow direction of the saline solution, most of the bubbles will gather near the microfiltration membrane assembly along the flow direction, so the gas cylinder will also extract the bubbles synchronously. Then, the saline solution mixed with gas is filled into the auxiliary cylinder at a high speed, so that the gas is mixed with the flowing saline solution again, and these steps are repeated to form microbubbles, thereby preparing a microbubble contrast agent.

[0017] (2) The contrast agent injection device can prevent the residual solid from piercing the microbubbles and causing the microbubble contrast agent to be damaged when there is residual solid left after cleaning by injecting the microbubble contrast agent and the contrast agent containing solid separately.

[0018] (3) The method for using the contrast agent injection device is to determine whether the prepared contrast agent is qualified by detecting the parameters of the contrast agent, thereby determining whether to continue the preparation.

[0019] Of course, any product implementing the present invention does not necessarily need to achieve all of the advantages described above at the same time. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is a schematic diagram of the overall structure of the contrast agent injection device of the present invention.

[0021] Figure 2 It is a schematic structural diagram of the vibrator of the contrast agent injection device of the present invention.

[0022] Figure 3 It is a schematic diagram of the internal structure of the injection barrel of the contrast agent injection device of the present invention.

[0023] Figure 4 It is a schematic structural diagram of the second electrically controlled valve of the contrast agent injection device of the present invention.

[0024] Figure 5 It is a schematic diagram of the structure of the electromagnet of the contrast agent injection device of the present invention.

[0025] Figure 6 This is a schematic diagram of the structure of the contrast agent injection device of the present invention where the slot is placed.

[0026] Figure 7 It is a schematic diagram of the structure of the return spring of the contrast agent injection device of the present invention.

[0027] Figure 8 It is a structural schematic diagram of the microfiltration membrane component of the contrast agent injection device of the present invention.

[0028] Fig. 9It is a schematic diagram of the structure of the flexible connection part of the contrast agent injection device of the present invention.

[0029] Fig.10 It is a schematic diagram of the structure of the delivery tube of the contrast agent injection device of the present invention.

[0030] Fig.11 This is a partial enlarged view of the microfiltration membrane component of the contrast agent injection device of the present invention.

[0031] Fig.12 It is a schematic diagram of the structure of the support frame of the contrast agent injection device of the present invention.

[0032] Fig.13 It is a schematic diagram of the structure of the connection cover of the contrast agent injection device of the present invention.

[0033] Fig.14 It is a schematic diagram of the internal structure of the liquid storage tank of the contrast agent injection device of the present invention.

[0034] Fig.15 It is a partial enlarged view of the receiving part of the contrast agent injection device of the present invention.

[0035] Fig.16 It is a schematic diagram of the structure of the liquid outlet valve of the contrast agent injection device of the present invention.

[0036] Fig.17 This is a schematic diagram of the structure of the cleaning cylinder of the contrast agent injection device of the present invention.

[0037] Fig.18 The present invention is a flowchart of the method for using the contrast agent injection device.

[0038] In the figure, 1, syringe; 101, columnar part; 102, injection part; 2, injection tube; 3, sampling tube; 4, vibrator; 5, auxiliary tube; 501, reciprocating part; 502, receiving part; 6, air pipe; 7, auxiliary tube; 8, first solenoid valve; 9, first electric control valve; 10, outflow part; 11, connecting pipe; 12, second electric control valve; 13, second solenoid valve; 14, air extraction valve; 15, movable part; 16, hole groove; 17, third electric control valve; 18, placement groove; 19, guide column; 20, hole groove plate; 21, plug column; 22, wireless charging battery module; 23, electromagnet; 24, reset spring; 25, threaded rod; 26, microfiltration membrane assembly; 27, first spur gear; 28, second spur gear; 29, rotating motor ; 30. Piston column; 31. Flexible connecting part; 32. Lifting part; 33. Air cylinder; 34. Inlet valve; 35. Delivery pipe; 36. Control valve; 37. Injection piece; 3701. Annular tube; 3702. Injection needle; 38. Packaging ring; 39. Support frame; 40. Cleaning cylinder; 41. Limit sleeve; 42. Liquid storage tank; 43. Water pump; 44. Liquid inlet pipe; 45. Driving motor; 46. Threaded column; 47. Movable plate; 48. Connecting column; 49. Connecting cover; 50. Perforation; 51. Cleaning valve; 52. Centrifugal motor; 53. Mounting piece; 54. Liquid outlet valve; 55. Round plate; 56. L-shaped plate; 57. Ring; 58. Closing plate; 59. Flushing valve; 60. First connecting plate; 61. Second connecting plate. DETAILED DESCRIPTION

[0039] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0040] In the description of the present invention, it should be understood that the terms "opening", "upper", "lower", "thickness", "top", "middle", "length", "inside", "all around" and the like indicating orientation or positional relationship are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the components or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the present invention.

[0041] See also Figure 1-Figure 17The embodiment of the present invention provides a technical solution: a contrast agent injection device, comprising a syringe 1, the bottom of the surface of the syringe 1 is connected to a liquid injection tube 2 through a connecting valve, the bottom of the surface of the syringe 1 is also connected to a sampling tube 3 through a connecting valve, and the surface of the syringe 1 is fixedly connected to a vibrator 4; the bottom end of the syringe 1 is connected to a contrast agent classification outflow component, the contrast agent classification outflow component is used to classify and divert pure liquid contrast agents and solid-liquid mixed contrast agents, and the top of the syringe 1 is connected to two auxiliary cylinders 5 through a diverter; the surface of the auxiliary cylinder 5 is connected to a mixing injection component, the mixing injection component is used to mix additional materials into physiological saline to prepare contrast agents; The auxiliary cylinder 5 includes a reciprocating part 501 and a receiving part 502, the mixed material injection assembly is connected to the receiving part 502, the bottom of the reciprocating part 501 is movably connected to the top of the receiving part 502, and two packaging rings 38 are connected to the surface of the receiving part 502. The packaging rings 38 are used to package the connection position between the reciprocating part 501 and the receiving part 502, and the receiving part 502 is connected to the diverter.

[0042] A suction assembly is provided inside the auxiliary tube 5, and an air tube 6 is connected to the surface of the injection tube 1 through a connecting valve. The air tube 6 and the suction assembly are used to make the physiological saline injected through the injection tube 2 flow back and forth in the injection tube 2 and the auxiliary tube 5 to mix the physiological saline with the additional material; the sampling tube 3 is used to deliver the prepared contrast agent into the detection device, and determine whether the preparation is completed based on the detection result of the detection device.

[0043] It also includes: a support frame 39 and a cleaning cylinder 40. The support frame 39 is connected to a cleaning structure for cleaning the injection cylinder 1. When the cleaning structure cleans the injection cylinder 1, the cleaning structure is connected to the receiving portion 502 through the cleaning cylinder 40. The surface of the injection cylinder 1 is movably sleeved with a limiting sleeve 41, and the limiting sleeve 41 is fixedly connected to the support frame 39.

[0044] Specifically, the contrast agent classification outflow component includes a solid-liquid mixed contrast agent outflow structure and a pure liquid contrast agent outflow structure. The syringe 1 includes a columnar portion 101 and an injection portion 102. The columnar portion 101 is fixedly connected to the injection portion 102, and the outlet of the injection portion 102 is fixedly connected to a first solenoid valve 8; the solid-liquid mixed contrast agent outflow structure is fixedly connected to the outside of the columnar portion 101, and the outlet of the solid-liquid mixed contrast agent outflow structure is fixedly connected to the outlet of the first solenoid valve 8; the pure liquid contrast agent outflow structure is movably arranged inside the columnar portion 101.

[0045] The solid-liquid mixed contrast agent outflow structure includes a first electrically controlled valve 9 and an outflow piece 10. The first electrically controlled valve 9 is fixedly connected to the surface of the cylindrical portion 101, and one end of the outflow piece 10 is fixedly connected to the position of the cylindrical portion 101 corresponding to the first electrically controlled valve 9; the other end of the outflow piece 10 is fixedly connected to a connecting tube 11, and the surface of the connecting tube 11 is fixedly connected to a second electrically controlled valve 12, one end of the connecting tube 11 is fixedly connected to the outlet of the first solenoid valve 8, and the other end of the connecting tube 11 is fixedly connected to the second solenoid valve 13; the top of the outflow piece 10 is fixedly connected to an exhaust valve 14, and the exhaust valve 14 is used to connect to an external exhaust device.

[0046] In this embodiment, the contrast agent containing solid particles is injected using the solid-liquid mixed contrast agent outflow structure, the first electrically controlled valve 9 is opened, and the injection piece 37 injects gas into the auxiliary tube 5, while the exhaust valve 14 extracts gas to the outside, so that the contrast agent containing solid particles fills the outflow piece 10, and then the second electrically controlled valve 12 and the second solenoid valve 13 are opened for injection.

[0047] The two different methods are used to prevent residual solids from puncturing the microbubbles due to incomplete cleaning, resulting in damage to the microbubble contrast agent.

[0048] Specifically, the pure liquid contrast agent outflow structure includes a movable part 15, a hole groove 16 is provided on the surface of the movable part 15, and a third electric control valve 17 is fixedly connected inside the hole groove 16; a placement groove 18 is also provided on the surface of the movable part 15, and the inner wall of the placement groove 18 is movably connected to a guide column 19, one end of the guide column 19 is fixedly connected to a hole groove plate 20, and the surface of the hole groove plate 20 is fixedly connected to a plug column 21, and the surface of the plug column 21 is movably connected to the inner wall of the hole groove 16; a wireless charging battery module 22 is fixedly connected to the bottom of the movable part 15, the wireless charging battery module 22 is fixedly connected to the electromagnet 23, and the electromagnet 23 is connected to the guide column 19; a return spring 24 is sleeved on the surface of the guide column 19, one end of the return spring 24 is fixedly connected to the surface of the hole groove plate 20, and the other end of the return spring 24 is fixedly connected to the surface of the movable part 15.

[0049] In this embodiment, the first solenoid valve 8 is opened at this time, and the auxiliary tube 7 on the auxiliary tube 5 that does not contain the microfiltration membrane assembly 26 simultaneously injects air into the auxiliary tube 5, and the electromagnet 23 is powered off by the wireless charging battery module 22. Under the action of the reset spring 24, the guide column 19 drives the hole slot plate 20 and the plug column 21 to move upward, so that the hole slot 16 leaks out, the third electric control valve 17 is opened, the second solenoid valve 13 is opened, and the exhaust device is first connected to the bottom of the connecting tube 11 to quickly extract the gas in the injection part 102 to prevent the gas from moving from bottom to top and destroying the microbubbles. After that, the connecting tube 11 is connected to the syringe, and the microbubble contrast agent can flow out of the syringe 1 and can be injected.

[0050] Specifically, the pure liquid contrast agent outflow structure is arranged above the trachea 6, and the suction assembly includes a piston member and a threaded rod 25. The piston member is arranged above the mixture injection assembly, and one end of the threaded rod 25 is movably connected to the piston member; the other end of the threaded rod 25 movably passes through the top of the auxiliary cylinder 5 and is threadedly connected to the first spur gear 27. The first spur gear 27 is movably connected to the auxiliary cylinder 5 through a bearing. The top of the auxiliary cylinder 5 is connected to the second spur gear 28 through a fixed plate. The second spur gear 28 is fixedly connected to the rotating motor 29, and the first spur gear 27 is meshed with the second spur gear 28.

[0051] Specifically, the piston member includes a piston column 30, a flexible connection part 31 and a lifting part 32, the piston column 30 is fixedly connected to one end of the flexible connection part 31, the other end of the flexible connection part 31 is fixedly connected to the lifting part 32, and the lifting part 32 is movably connected to one end of the threaded rod 25.

[0052] In this embodiment, in order to reduce the pressure in the auxiliary cylinder 5 when the gas is filled, the piston member includes a piston column 30, a flexible connection part 31 and a lifting part 32. When the gas is filled into the auxiliary cylinder 5, the internal pressure will increase, and the flexible connection part 31 will be squeezed by the piston column 30 to compress the flexible connection part 31, thereby achieving pressure reduction.

[0053] Specifically, the mixed material injection assembly includes an air cylinder 33 and two injection structures, the two injection structures are respectively connected to two receiving parts 502, and an air intake valve 34 is fixedly connected to the air cylinder 33; the injection structure includes a delivery pipe 35 and two control valves 36 connected to the delivery pipe 35, and the end of the delivery pipe 35 away from the control valve 36 is connected to the air cylinder 33 through an on-off valve, and the control valve 36 is connected to the injection piece 37; two microfiltration membrane assemblies 26 are fixedly connected inside one of the receiving parts 502, and the two injection pieces 37 are located between the two microfiltration membrane assemblies 26; the surface of the delivery pipe 35 is connected to the auxiliary pipe 7 through a shut-off valve.

[0054] The end of the delivery tube 35 is sleeved on the input port of the control valve 36. When in use, the end of the delivery tube 35 can be connected to the input port of the control valve 36. When not in use, it can be disassembled. Similarly, the connection between the air pipe 6 and the sampling tube 3 and the connecting valve is also detachable.

[0055] Specifically, the injection member 37 includes an annular tube 3701 and an injection needle 3702 . The injection needle 3702 is fixedly connected to the annular tube 3701 . The injection needle 3702 penetrates into the interior of the auxiliary tube 5 . The annular tube 3701 is fixedly connected to the surface of the receiving portion 502 .

[0056] In this embodiment, in order to accelerate the generation of microbubbles, the gas cylinder 33 extracts part of the saline through the injection piece 37. In addition, the injection piece 37 is attached to the microfiltration membrane assembly 26. Regardless of the flow direction of the saline, most of the bubbles will gather near the microfiltration membrane assembly 26 along the flow direction, so the gas cylinder 33 will also extract the bubbles synchronously. Then, the saline mixed with gas is filled into the auxiliary cylinder 5 at a high speed, so that the gas is mixed with the flowing saline again, and these steps are repeated to form microbubbles with the gas, thereby preparing a microbubble contrast agent.

[0057] Specifically, the cleaning structure includes a liquid storage tank 42, which is fixedly installed on the top of the support frame 39, and a water pump 43 is fixedly connected to one side of the liquid storage tank 42, and a liquid inlet pipe 44 is fixedly connected to the water inlet end of the water pump 43; when the injection cylinder 1 is cleaned, the end of the liquid inlet pipe 44 away from the water pump 43 is connected to the connecting pipe 11 through a sealed bearing; a driving motor 45 is fixedly connected to the inside of the liquid storage tank 42, and the driving motor 45 is transmission-connected to a threaded column 46 through a gear box, and a movable plate 47 is threadedly sleeved on the surface of the threaded column 46, and the surface of the movable plate 47 is movably connected to the inner wall of the liquid storage tank 42, and a connecting column 48 that movably penetrates the movable plate 47 is fixedly connected to the inside of the liquid storage tank 42; a liquid inlet valve and an exhaust valve are respectively provided on the top of the liquid storage tank 42, and a drain valve is also provided on the surface of the liquid storage tank 42.

[0058] Specifically, the tops of the two reciprocating parts 501 are movably connected to the connecting cover 49, the top of the connecting cover 49 is provided with a through hole 50, the top of the cleaning cylinder 40 is fixedly connected with a cleaning valve 51, and the size of the cleaning valve 51 is adapted to the size of the through hole 50; the top of the connecting cover 49 is fixedly connected with a centrifugal motor 52, the top of the centrifugal motor 52 is fixedly connected with a mounting member 53, the bottom of the liquid storage tank 42 is provided with a liquid outlet valve 54, the bottom of the liquid storage tank 42 is fixedly connected with a circular plate 55 through a fixing column, the bottom of the circular plate 55 is fixedly connected with an L-shaped plate 56, and the L-shaped plate 56 It is fixedly connected to the mounting member 53 by bolts; the circular plate 55 is connected to the circular ring 57 by a first connecting bearing, the circular ring 57 is connected to the closing plate 58 by a second connecting bearing, the closing plate 58 is fixedly connected to the bottom of the liquid storage tank 42, a flushing valve 59 is installed at the bottom of the circular ring 57, when the injection cylinder 1 is cleaned, the flushing valve 59 is connected to the cleaning valve 51 through a water pipe; the bottom of the circular ring 57 is fixedly connected to the first connecting plate 60, the top of the connecting cover 49 is fixedly connected to the second connecting plate 61, and the first connecting plate 60 and the second connecting plate 61 can be connected by screws.

[0059] In this embodiment, the centrifugal motor 52 is started, and the auxiliary cylinder 5 and the injection cylinder 1 are driven to rotate synchronously through the connection cover 49, and the limiting sleeve 41 can play a limiting role. Under the action of centrifugal force, some unqualified impurity particles with large density and undissolved solid raw materials can quickly settle to the bottom of the injection cylinder 1, achieving preliminary precipitation separation and improving the purity of the contrast agent.

[0060] For contrast agents containing solid particles, a centrifugal motor 52 is required for cleaning. The first solenoid valve 8 and the third electrically controlled valve 17 are closed, and the second electrically controlled valve 12, the second solenoid valve 13 and the first electrically controlled valve 9 are opened. During the flow of the cleaning liquid, the centrifugal motor 52 is started synchronously. During the process of flushing the solid particles with the cleaning liquid, the solid particles will also settle rapidly under the action of centrifugal force and enter the interior of the liquid storage tank 42 through the water pump 43. Filter cotton is installed inside the liquid storage tank 42 through the installation cover to filter the solid particles.

[0061] A method for using a contrast medium injection device is applied to the above-mentioned contrast medium injection device, such as Fig.18 As shown, the method comprises the following steps: injecting physiological saline into the syringe 1 through the injection tube 2, and the mixing material injection assembly simultaneously extracts the gas in the syringe 1, and the injection is stopped after the injection of the physiological saline is completed; the suction assembly and the trachea 6 act, and when the trachea 6 injects gas into the syringe 1, the suction assembly moves upward to transfer the physiological saline to the auxiliary tube 5, and then the gas in the syringe 1 is discharged through the trachea 6, and the suction assembly moves downward, and the physiological saline is transferred from the auxiliary tube 5 to the syringe 1, so that the physiological saline flows back and forth; in the process of the reciprocating flow of the physiological saline, the mixing material is injected into the auxiliary tube 5 through the mixing material injection assembly, so that the physiological saline is mixed with the mixing material, wherein the mixing material includes gas, radioactive raw materials and solid raw materials; after mixing for a period of time, the sampling tube 3 sends part of the contrast agent into the detection device, and the detection device outputs the detection result. If the detection result is unqualified, the preparation is continued, and if the detection result is qualified, the preparation is stopped; the qualified contrast agent is output through the contrast agent classification outflow assembly; after the contrast agent is used, the syringe 1 is cleaned by the cleaning structure.

[0062] When it is necessary to prepare microbubble developer, the injection tube 2 is connected to the saline bottle, the connecting valve is opened, and the saline in the saline bottle is fed into the syringe 1 through the liquid supply device. At the same time, the separator is activated to connect the syringe 1 with the auxiliary cylinder 5 containing the microfiltration membrane assembly 26, wherein the separator can be composed of three valves, one end of the three valves is connected, and the other end is respectively connected to the syringe 1 and the two auxiliary cylinders 5.

[0063] When the normal saline enters the syringe 1, the upper control valve 36 on the delivery tube 35 connected to the auxiliary tube 5 containing the microfiltration membrane assembly 26 is opened, and at the same time the shut-off valve is opened, and the auxiliary tube 7 is connected to the external vacuum equipment to extract the gas in the syringe 1, so that the normal saline can enter smoothly and prevent the pressure in the syringe 1 from being too high.

[0064] After the saline contacts the injection needle 3702 of the injection member 37 above, the injection of saline is stopped. Then the shut-off valve is closed, and the control valve 36 is also closed. The air inlet valve 34 is opened, and the cylinder 33 draws in an appropriate amount of gas, and then the air inlet valve 34 is closed. Both control valves 36 and the on-off valve are opened, and the saline flows back and forth between the injection cylinder 1 and the auxiliary cylinder 5. The cylinder 33 injects the gas into the flowing saline through the annular tube 3701 and the injection needle 3702. There are multiple injection needles 3702, and they are of different lengths, so that the gas can be injected evenly.

[0065] In addition, the two injection parts 37 are arranged in the middle of the two microfiltration membrane components 26. The air injected through the injection needle 3702 will produce bubbles and will be mixed in the flowing saline. However, the microfiltration membrane component 26 includes a microfiltration membrane and a metal mesh on both sides of the microfiltration membrane. The microfiltration membrane can filter larger bubbles. Therefore, some bubbles will be retained between the two microfiltration membrane components 26. The flowing saline will squeeze these bubbles, thereby forcing the large bubbles to burst and form microbubbles, which will pass through the microfiltration membrane component 26.

[0066] In order to accelerate the generation of microbubbles, the gas cylinder 33 extracts part of the saline solution through the injection piece 37. In addition, the injection piece 37 is attached to the microfiltration membrane assembly 26. Regardless of the flow direction of the saline solution, most of the bubbles will gather near the microfiltration membrane assembly 26 along the flow direction, so the gas cylinder 33 will also extract the bubbles synchronously. Then, the saline solution mixed with gas is filled into the auxiliary cylinder 5 at a high speed, so that the gas is mixed with the flowing saline solution again. These steps are repeated to form microbubbles with the gas, thereby preparing a microbubble contrast agent.

[0067] In order to reduce the pressure in the auxiliary cylinder 5 when the gas is filled, the piston member includes a piston column 30, a flexible connection part 31 and a lifting part 32. When the gas is filled into the auxiliary cylinder 5, the internal pressure will increase, and the flexible connection part 31 will be squeezed by the piston column 30 to compress the flexible connection part 31, thereby achieving pressure reduction.

[0068] After repeating the above steps for a period of time, the microbubbles need to be tested to determine whether they meet the requirements. The testing method is as follows: The detection device acquires microbubble data, compares the microbubble data with the microbubble parameter data stored in the database, and obtains a microbubble comparison coefficient, wherein the microbubble data includes microbubble diameter, concentration and scattering cross section, and the microbubble parameter data includes a parameterized microbubble diameter, a parameterized concentration and a parameterized scattering cross section: ;

[0069] In the formula, is the microbubble contrast coefficient, is the microbubble diameter, is the concentration, is the scattering cross section, To determine the microbubble diameter, is the reference concentration, is the parameterized scattering cross section; If the microbubble comparison coefficient is greater than the microbubble comparison threshold stored in the database, the test result is unqualified; if the microbubble comparison coefficient is not greater than the microbubble comparison threshold stored in the database, the test result is qualified.

[0070] The detection device will obtain three important data of the microbubble contrast agent, namely the microbubble diameter, concentration and scattering cross section. These actual measured data are then compared with the corresponding standard parameter data stored in the database, namely the parameterized microbubble diameter, parameterized concentration and parameterized scattering cross section. The formula calculates the degree of deviation of the microbubble diameter and concentration, as well as the relative difference in the scattering cross section, to comprehensively derive the microbubble comparison coefficient wb. The formula uses an exponential function for the deviation of the microbubble diameter and concentration, and a logarithmic function for the scattering cross section, making the detection method very sensitive to changes in these parameters. Whether it is a slight change in the microbubble diameter or concentration, or a relative change in the scattering cross section, it can cause a significant change in the microbubble comparison coefficient wb. This sensitivity helps to accurately detect whether the microbubble contrast agent meets the quality requirements and ensure imaging quality.

[0071] After the test result is qualified, in order to increase the storage time of the microbubbles, the microbubbles can be mixed with phospholipids so that a layer of phospholipids is attached to the surface of the microbubbles. The upper injection piece 37 on the auxiliary cylinder 5 containing the microfiltration membrane assembly 26 uses the auxiliary tube 7 on the delivery tube 35 to inject air into the auxiliary cylinder 5, and at the same time, the classifier connects another auxiliary cylinder 5 with the injection cylinder 1. The auxiliary cylinder 5 does not contain the microfiltration membrane assembly 26. The upper injection piece 37 on the auxiliary cylinder 5 that does not contain the microfiltration membrane assembly 26 uses the auxiliary tube 7 on the delivery tube 35 to pump air outward, thereby transferring the microbubble contrast agent.

[0072] Afterwards, the auxiliary tube 7 on the auxiliary tube 5 that does not include the microfiltration membrane assembly 26 slowly injects phospholipids into the two injection parts 37 on the auxiliary tube 5. At the same time, the piston in the auxiliary tube 5 moves upward under the action of the threaded rod 25. At the same time, the pure liquid contrast agent outflow structure moves upward under the action of air pressure to achieve the mixing of the flowing microbubble contrast agent and phospholipids. After the microbubble contrast agent realizes a reciprocating motion, it returns to the injection tube 1 and is ready for injection.

[0073] At this time, the first solenoid valve 8 is opened, and the auxiliary tube 7 on the auxiliary tube 5 that does not contain the microfiltration membrane assembly 26 simultaneously injects air into the auxiliary tube 5. The electromagnet 23 is powered off by the wireless charging battery module 22. Under the action of the reset spring 24, the guide column 19 drives the hole slot plate 20 and the plug column 21 to move upward, so that the hole slot 16 leaks out. The third electric control valve 17 is opened, and the second solenoid valve 13 is opened. The exhaust device is first connected to the bottom of the connecting tube 11 to quickly extract the gas in the injection part 102 to prevent the gas from moving from bottom to top and destroying the microbubbles. After that, the connecting tube 11 is connected to the syringe, and the microbubble contrast agent can flow out of the syringe 1 and can be injected.

[0074] When the mixed material is a radioactive raw material and a solid raw material, the same method is used to inject physiological saline into the syringe 1, but the auxiliary cylinder 5 without the microfiltration membrane assembly 26 is connected to the syringe 1, and the vibrator 4 provided on the syringe 1 vibrates to vibrate the gas in the physiological saline to flow upward, so that it is drawn away by the injection member 37. After the injection of the physiological saline is completed, the radioactive raw material solution and the solid raw material solution are injected into the auxiliary cylinder 5 through the auxiliary tube 7, and mixed in the process of the physiological saline flowing, and the gas cylinder 33 cooperates to accelerate the mixing.

[0075] When the mixed material is a solid raw material, the centrifugal motor 52 is used to assist in the final stage of mixing. Before starting the centrifugal motor 52, the connecting valve connected to the air pipe 6 and the sampling tube 3 is closed, and then the air pipe 6 and the sampling tube 3 are removed, and then the control valve 36 is closed and the delivery pipe 35 is removed.

[0076] The centrifugal motor 52 is started, and the auxiliary cylinder 5 and the injection cylinder 1 are driven to rotate synchronously through the connecting cover 49, and the limit sleeve 41 can play a role of limiting. Under the action of centrifugal force, some unqualified impurity particles with larger density and undissolved solid raw materials can quickly settle to the bottom of the injection cylinder 1, achieving preliminary precipitation separation and improving the purity of the contrast agent. For the larger impurity particles and undissolved solid raw materials that have settled, they can be discharged through the solid-liquid mixed state contrast agent outflow structure, specifically: the first electric control valve 9 is opened, and the injection piece 37 injects gas into the auxiliary cylinder 5 at the same time, and the exhaust valve 14 simultaneously extracts gas to the outside, so that the contrast agent containing larger impurity particles and undissolved solid raw materials fills the outflow piece 10, and then the second electric control valve 12 and the second solenoid valve 13 are opened, and the injection piece 37 injects gas into the auxiliary cylinder 5 at the same time, so that this part of the waste liquid can be discharged.

[0077] For radioactive contrast agents, the same injection method as microbubble contrast agents can be used, and for contrast agents containing solid particles, the solid-liquid mixed contrast agent outflow structure is used for injection. The first electrically controlled valve 9 is opened, and the injection piece 37 injects gas into the auxiliary tube 5 at the same time. The exhaust valve 14 simultaneously extracts gas to the outside, so that the contrast agent containing solid particles fills the outflow piece 10. After that, the second electrically controlled valve 12 and the second solenoid valve 13 are opened, and injection can be carried out.

[0078] The two different methods are used to prevent residual solids from piercing the microbubbles when there are residues after cleaning, resulting in damage to the microbubble contrast agent.

[0079] After the injection, the residual contrast agent can be cleaned. The same cleaning method can be used for microbubble contrast agents and radioactive contrast agents: First, remove the bolts between the L-shaped plate 56 and the mounting member 53, then lift the centrifugal motor 52 and the connecting cover 49 upwards, and remove the connecting cover 49. Then remove the limiting sleeve 41, wherein the limiting sleeve 41 is formed by two symmetrical clamping rings fixed by screws. After removing the limiting sleeve 41, the two reciprocating parts 501 can be removed, and then the two cleaning cylinders 40 are respectively connected to the two receiving parts 502, and then the limiting sleeve 41 is installed to fix the cleaning cylinder 40 and the receiving part 502.

[0080] A cleaning valve 51 is fixedly connected to one of the cleaning cylinders 40, and the connection cover 49 is covered on the two cleaning cylinders 40, so that the cleaning valve 51 passes through the through hole 50, and the L-shaped plate 56 is fixed to the mounting member 53 by bolts. Then, the flushing valve 59 is connected to the cleaning valve 51 through a water pipe, and the first connecting plate 60 and the second connecting plate 61 are fixedly connected by screws.

[0081] The cleaning liquid is injected into the liquid storage tank 42 through the liquid inlet valve on the liquid storage tank 42, the liquid outlet valve 54, the flushing valve 59 and the cleaning valve 51 are all opened, the cleaning liquid enters the cleaning cylinder 40, the receiving part 502 and the injection cylinder 1, the first solenoid valve 8, the second solenoid valve 13 and the third electric control valve 17 are all opened, the water pump 43 is started, and water is pumped into the liquid storage tank 42 through the liquid inlet pipe 44. The movable plate 47 divides the liquid storage tank 42 into two parts, and the new cleaning liquid is injected through the liquid inlet valve, and the cleaning liquid after cleaning enters the other part of the liquid storage tank 42.

[0082] When both parts of the liquid storage tank 42 are filled with cleaning liquid, the driving motor 45 is started to drive the movable plate 47 to reciprocate. When the movable plate 47 moves toward the direction close to the liquid inlet valve, the new cleaning liquid can be squeezed to make the cleaning liquid flow quickly, and when the movable plate 47 moves toward the direction away from the liquid inlet valve, the cleaned cleaning liquid can be squeezed to accelerate its discharge through the discharge valve.

[0083] It should be noted that by replacing the positions of the two cleaning cylinders 40 , the two receiving parts 502 can be cleaned.

[0084] For contrast agents containing solid particles, a centrifugal motor 52 is required for cleaning, and the positions of the two cleaning cylinders 40 are not changed: The first solenoid valve 8 and the third electrically controlled valve 17 are both closed, the second electrically controlled valve 12, the second solenoid valve 13 and the first electrically controlled valve 9 are all opened, and during the flow of the cleaning liquid, the centrifugal motor 52 is started synchronously. During the process of the cleaning liquid flushing the solid particles, the solid particles will also settle rapidly under the action of centrifugal force and enter the interior of the liquid storage tank 42 through the water pump 43. Filter cotton is installed inside the liquid storage tank 42 through the installation cover to filter the solid particles.

[0085] For radioactive contrast agents and contrast agents containing solid particles, the method for testing whether they are qualified is as follows: The detection device acquires radiation data, compares the radiation data with the radiation parameter data stored in the database, and obtains a radioactivity comparison coefficient, wherein the radiation data includes radioactivity activity, energy and particle range, and the radiation parameter data includes parameterized radioactivity activity, parameterized energy and parameterized particle range: ; In the formula, is the radioactivity comparison coefficient, is the radioactivity, For energy, is the particle range, To determine the radioactivity, To determine the energy, To determine the particle range, is a natural constant; If the radioactivity comparison coefficient is greater than the radioactivity comparison threshold stored in the database, the test result is unqualified; if the radioactivity comparison coefficient is not greater than the radioactivity comparison threshold stored in the database, the test result is qualified.

[0086] The three key radioactive data of the radioactive contrast agent, namely the radioactivity, energy and particle range, are obtained respectively. Then they are compared with the corresponding reference data, namely the standard radioactivity, energy and particle range. The radioactivity comparison coefficient fb is calculated by the above formula. The exponential function e and absolute value operation are used in this formula, the purpose of which is to comprehensively consider the degree of deviation of the three parameters from the standard values. As long as any of the parameters deviates greatly from the standard value, the value of the exponential part will increase significantly, thereby increasing the radioactivity comparison coefficient fb. Finally, the qualification of the test result is determined based on the relationship between fb and the radioactivity comparison threshold.

[0087] The detection device acquires particle data, compares the particle data with the particle parameter data stored in the database, and obtains the solid comparison coefficient, wherein the particle data includes particle size and density, and the particle parameter data includes parameterized particle size and parameterized density: ; In the formula, is the solid contrast coefficient, is the particle size, is the density, To determine the particle size, is the parameter density; If the solid comparison coefficient is greater than the solid comparison threshold stored in the database, the test result is unqualified; if the solid comparison coefficient is not greater than the solid comparison threshold stored in the database, the test result is qualified.

[0088] The detection device first obtains two key particle data, namely, the particle size and density of the solid particle contrast agent. These data are then compared with the standard reference particle size and reference density pre-stored in the database. The solid comparison coefficient gb is calculated by comprehensively considering the degree of difference between the particle size and density and the standard value through the set formula. In the formula, the absolute value operation is used to ensure the non-negativity of the difference between the particle data and the reference data. For the particle size, |gks-gkc| calculates the degree of deviation between the actual particle size and the reference particle size; for the density, |gms-gmc| calculates the degree of deviation between the actual density and the reference density. The addition of these two deviations is used as the exponential part of the exponential function e, which means that as long as there is any deviation between the particle size or density and the standard value, the value of the exponential part will increase, thereby increasing the solid comparison coefficient gb. Finally, the qualification of the test result is determined based on the relationship between gb and the solid comparison threshold.

[0089] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0090] The preferred embodiments of the present invention disclosed above are only used to help illustrate the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to the specific implementation methods described. Obviously, many modifications and changes can be made according to the content of this specification. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the present invention, so that those skilled in the art can understand and use the present invention well. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. A contrast agent injection device, comprising a syringe (1), characterized in that: The bottom of the surface of the injection barrel (1) is connected to a liquid injection tube (2) via a connecting valve, the bottom of the surface of the injection barrel (1) is also connected to a sampling tube (3) via a connecting valve, and a vibrator (4) is fixedly connected to the surface of the injection barrel (1); The bottom end of the syringe (1) is connected to a contrast medium classification outflow component, which is used to classify and divert pure liquid contrast medium and solid-liquid mixed contrast medium. The top of the syringe (1) is connected to two auxiliary cylinders (5) via a diverter. The surface of the auxiliary cylinder (5) is connected to a mixing material injection assembly, and the mixing material injection assembly is used to mix additional materials into physiological saline to prepare a contrast agent; The auxiliary cylinder (5) comprises a reciprocating portion (501) and a receiving portion (502), the mixed material injection assembly is connected to the receiving portion (502), the bottom of the reciprocating portion (501) is movably connected to the top of the receiving portion (502), the surface of the receiving portion (502) is connected to two packaging rings (38), the packaging rings (38) are used to package the connection position between the reciprocating portion (501) and the receiving portion (502), and the receiving portion (502) is connected to the diverter; A suction assembly is provided inside the auxiliary cylinder (5), and a trachea (6) is connected to the surface of the injection cylinder (1) via a connecting valve. The trachea (6) and the suction assembly are used to allow the physiological saline injected through the injection tube (2) to flow back and forth in the injection tube (2) and the auxiliary cylinder (5), so that the physiological saline is mixed with the additional material; The sampling tube (3) is used to deliver the prepared contrast agent into the detection device, and determine whether the preparation is completed based on the detection result of the detection device; Also includes: A support frame (39) and a cleaning cylinder (40), wherein the support frame (39) is connected to a cleaning structure for cleaning the injection cylinder (1), and when the cleaning structure cleans the injection cylinder (1), the cleaning structure is connected to the receiving portion (502) via the cleaning cylinder (40); A limiting sleeve (41) is movably sleeved on the surface of the injection cylinder (1), and the limiting sleeve (41) is fixedly connected to the support frame (39).

2. A contrast agent injection device according to claim 1, characterized in that: The contrast agent classification outflow component comprises a solid-liquid mixed contrast agent outflow structure and a pure liquid contrast agent outflow structure, the syringe (1) comprises a columnar portion (101) and an injection portion (102), the columnar portion (101) is fixedly connected to the injection portion (102), and a first solenoid valve (8) is fixedly connected to the outlet of the injection portion (102); The solid-liquid mixed contrast agent outflow structure is fixedly connected to the outside of the columnar portion (101), and the outlet of the solid-liquid mixed contrast agent outflow structure is fixedly connected to the outlet of the first solenoid valve (8); The pure liquid contrast agent outflow structure is movably arranged inside the columnar portion (101).

3. A contrast agent injection device according to claim 2, characterized in that: The solid-liquid mixed contrast agent outflow structure comprises a first electrically controlled valve (9) and an outflow piece (10), wherein the first electrically controlled valve (9) is fixedly connected to the surface of the columnar portion (101), and one end of the outflow piece (10) is fixedly connected to a position of the columnar portion (101) corresponding to the first electrically controlled valve (9); The other end of the outflow member (10) is fixedly connected to a connecting pipe (11), a surface of the connecting pipe (11) is fixedly connected to a second electrically controlled valve (12), one end of the connecting pipe (11) is fixedly connected to an outlet of the first solenoid valve (8), and the other end of the connecting pipe (11) is fixedly connected to a second solenoid valve (13); The top of the outflow piece (10) is fixedly connected to an air extraction valve (14), and the air extraction valve (14) is used to be connected to an external air extraction device.

4. A contrast agent injection device according to claim 3, characterized in that: The pure liquid contrast agent outflow structure comprises a movable part (15), a hole groove (16) is formed on the surface of the movable part (15), and a third electric control valve (17) is fixedly connected inside the hole groove (16); The surface of the movable part (15) is also provided with a placement groove (18), the inner side wall of the placement groove (18) is movably connected to a guide column (19), one end of the guide column (19) is fixedly connected to a hole groove plate (20), the surface of the hole groove plate (20) is fixedly connected to an insertion column (21), and the surface of the insertion column (21) is movably connected to the inner side wall of the hole groove (16); A wireless charging battery module (22) is fixedly connected to the bottom of the movable part (15), the wireless charging battery module (22) is fixedly connected to an electromagnet (23), and the electromagnet (23) is connected to a guide column (19); A return spring (24) is sleeved on the surface of the guide column (19), one end of the return spring (24) is fixedly connected to the surface of the hole slot plate (20), and the other end of the return spring (24) is fixedly connected to the surface of the movable member (15).

5. A contrast agent injection device according to claim 2, characterized in that: The pure liquid contrast agent outflow structure is arranged above the trachea (6); the suction assembly comprises a piston and a threaded rod (25); the piston is arranged above the mixed material injection assembly; one end of the threaded rod (25) is movably connected to the piston; The other end of the threaded rod (25) movably passes through the top of the auxiliary cylinder (5) and is threadedly connected to the first spur gear (27); the first spur gear (27) is movably connected to the auxiliary cylinder (5) via a bearing; the top of the auxiliary cylinder (5) is connected to a second spur gear (28) via a fixing plate; the second spur gear (28) is fixedly connected to a rotating motor (29); the first spur gear (27) meshes with the second spur gear (28); The piston member comprises a piston column (30), a flexible connection portion (31) and a lifting portion (32); the piston column (30) is fixedly connected to one end of the flexible connection portion (31); the other end of the flexible connection portion (31) is fixedly connected to the lifting portion (32); and the lifting portion (32) is movably connected to one end of the threaded rod (25).

6. A contrast agent injection device according to claim 1, characterized in that: The mixed material injection assembly comprises an air cylinder (33) and two injection structures, the two injection structures are respectively connected to two receiving portions (502), and an air intake valve (34) is fixedly connected to the air cylinder (33); The injection structure comprises a delivery pipe (35) and two control valves (36) connected to the delivery pipe (35); one end of the delivery pipe (35) away from the control valve (36) is connected to the gas cylinder (33) via an on-off valve; and the control valve (36) is connected to an injection member (37); Two microfiltration membrane assemblies (26) are fixedly connected inside one of the receiving parts (502), and the two injection pieces (37) are located between the two microfiltration membrane assemblies (26); The surface of the delivery pipe (35) is connected to the auxiliary pipe (7) via a shut-off valve.

7. A contrast agent injection device according to claim 6, characterized in that: The injection member (37) comprises an annular tube (3701) and an injection needle (3702); the injection needle (3702) is fixedly connected to the annular tube (3701); the injection needle (3702) penetrates into the interior of the receiving portion (502); and the annular tube (3701) is fixedly connected to the surface of the receiving portion (502).

8. A contrast agent injection device according to claim 3, characterized in that: The cleaning structure comprises a liquid storage tank (42), the liquid storage tank (42) being fixedly mounted on the top of the support frame (39), a water pump (43) being fixedly connected to one side of the liquid storage tank (42), and a liquid inlet pipe (44) being fixedly connected to the water inlet end of the water pump (43); When the syringe barrel (1) is cleaned, the end of the liquid inlet pipe (44) away from the water pump (43) is connected to the connecting pipe (11) via a sealing bearing; The interior of the liquid storage tank (42) is fixedly connected to a driving motor (45), the driving motor (45) is transmission-connected to a threaded column (46) via a gear box, a movable plate (47) is threadedly sleeved on the surface of the threaded column (46), the surface of the movable plate (47) is movably connected to the inner side wall of the liquid storage tank (42), and a connecting column (48) movably penetrating the movable plate (47) is fixedly connected to the interior of the liquid storage tank (42); A liquid inlet valve and an exhaust valve are respectively arranged on the top of the liquid storage tank (42), and a drain valve is also arranged on the surface of the liquid storage tank (42).

9. A contrast agent injection device according to claim 8, characterized in that: The tops of the two reciprocating parts (501) are movably connected to the connecting cover (49), the top of the connecting cover (49) is provided with a through hole (50), the top of the cleaning cylinder (40) is fixedly connected with a cleaning valve (51), and the size of the cleaning valve (51) is adapted to the size of the through hole (50); The top of the connection cover (49) is fixedly connected to a centrifugal motor (52), the top of the centrifugal motor (52) is fixedly connected to a mounting member (53), the bottom of the liquid storage tank (42) is provided with a liquid outlet valve (54), the bottom of the liquid storage tank (42) is fixedly connected to a circular plate (55) via a fixing column, the bottom of the circular plate (55) is fixedly connected to an L-shaped plate (56), and the L-shaped plate (56) is fixedly connected to the mounting member (53) via bolts; The circular plate (55) is connected to the circular ring (57) via a first connecting bearing, the circular ring (57) is connected to the closing plate (58) via a second connecting bearing, the closing plate (58) is fixedly connected to the bottom of the liquid storage tank (42), a flushing valve (59) is installed at the bottom of the circular ring (57), and when the syringe (1) is cleaned, the flushing valve (59) is connected to the cleaning valve (51) via a water pipe; A first connecting plate (60) is fixedly connected to the bottom of the circular ring (57), and a second connecting plate (61) is fixedly connected to the top of the connecting cover (49). The first connecting plate (60) and the second connecting plate (61) can be connected by screws.

10. A method for using a contrast medium injection device, applied to a contrast medium injection device according to any one of claims 1 to 9, characterized in that: The following steps are involved: Injecting physiological saline into the syringe (1) through the injection tube (2), and the mixing injection component simultaneously extracts the gas in the syringe (1), and after the injection of the physiological saline is completed, the injection is stopped; The suction assembly and the trachea (6) are in motion. When the trachea (6) injects gas into the syringe (1), the suction assembly moves upward to transfer the saline solution to the auxiliary cylinder (5). After that, the gas in the syringe (1) is discharged through the trachea (6). The suction assembly moves downward to transfer the saline solution from the auxiliary cylinder (5) to the syringe (1), so that the saline solution flows back and forth. In the process of reciprocating flow of the physiological saline, a mixed material is injected into the auxiliary cylinder (5) through the mixed material injection assembly to mix the physiological saline with the mixed material, wherein the mixed material includes gas, radioactive raw materials and solid raw materials; After mixing for a period of time, the sampling tube (3) delivers part of the contrast agent to the detection device, and the detection device outputs the detection result. If the detection result is unqualified, the preparation continues; if the detection result is qualified, the preparation stops; Outputting qualified contrast medium through the contrast medium classification outflow component; After the contrast agent is used, the syringe (1) is cleaned by the cleaning structure.

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