Medicine composition for removing nevus and preparation method thereof

Abstract

The ointment is prepared from 18 to 22 parts of brucea javanica, 15 to 19 parts of herba patriniae, 14 to 18 parts of radix stemonae, 12 to 16 parts of gallnut, 12 to 16 parts of fructus cnidii, 11 to 15 parts of radix gentianae, 10 to 14 parts of chela japonica, 6 to 12 parts of cortex phellodendri, 3 to 7 parts of salicylic acid, 3 to 7 parts of borneol, 4 to 8 parts of vitamin E, 5 to 9 parts of glycerol, 0.3 to 0.7 part of cetostearyl alcohol, 0.2 to 0.6 part of triethanolamine, 20 to 30 parts of vaseline and 0.1 to 0.2 part of flurhexidine acetate. The invention belongs to the technical field of nevus-removing pharmaceutical compositions, and provides a nevus-removing pharmaceutical composition and a preparation method thereof, by selecting multiple traditional Chinese medicinal materials, the nevus-removing pharmaceutical composition achieves the effects of resisting inflammation, sterilizing, relieving itching and pain, replenishing water, moisturizing, calming and easing pain after removing nevus, forms a barrier with the skin surface layer, avoids fungal infection, and accelerates the recovery speed of the skin after removing the nevus.

Description

Technical Field

[0001] The invention belongs to the technical field of mole removal pharmaceutical compositions, and in particular relates to a mole removal pharmaceutical composition and a preparation method thereof. Background Art

[0002] Moles include various congenital and acquired melanocytic nevi, sebaceous nevi, etc. Moles are the most common benign skin tumors in humans, which are skin manifestations caused by the increase of melanocytes in the epidermis and dermis.

[0003] The most common methods of removing moles are:

[0004] 1. Chemical drugs, using strong acid or strong alkali chemical agents to burn, while hospitals use trichloroacetic acid to remove moles, which is more effective for newly appeared and relatively shallow combined moles. Excessive burning often causes sunken scars, or raised scars due to scar-prone constitution;

[0005] 2. Electrocautery is effective for shallow combined nevi and deep and raised compound nevi, but the operation is difficult to control and is prone to scarring;

[0006] 3. Freezing, freezing moles with liquid nitrogen, can effectively remove protruding and flat moles, but it is difficult to control the depth and often causes damage;

[0007] 4. Surgical excision can remove the mole once and for all. If there is a possibility of malignant transformation, pathological tissue examination can be carried out after excision. Excision is a type of surgery, so anesthesia and sutures must be applied, and the wound is more difficult to care for.

[0008] No matter which mole removal method is used in the prior art, it is very harmful to the skin and is easy to damage the dermis. The recovery effect varies from person to person. Some people are also prone to fungal infection due to the wound caused by mole removal. At the same time, these mole removal methods have a long recovery period, are not easy to remove completely, and are prone to recurrence. Summary of the invention

[0009] In view of the above situation, in order to overcome the defects of the prior art, the purpose of the present invention is to provide a mole removal pharmaceutical composition and a preparation method thereof. By selecting a variety of Chinese medicinal materials, the anti-inflammatory and bactericidal, itching and analgesic, moisturizing and sedative effects can be achieved after the mole is removed, and a barrier can be formed with the surface of the skin to avoid fungal infection and accelerate the recovery of the skin after the mole is removed.

[0010] The technical scheme adopted by the present invention is as follows: a mole-removing pharmaceutical composition of the present invention comprises the following components in parts by weight: 18-22 parts of Brucea javanica, 15-19 parts of Patrinia scabra, 14-18 parts of Stemona japonica, 12-16 parts of Galla chinensis, 12-16 parts of Cnidium monnieri, 11-15 parts of Gentiana scabra, 10-14 parts of Cyperus rotundus, 6-12 parts of Phellodendron chinense, 3-7 parts of salicylic acid, 3-7 parts of borneol, 4-8 parts of vitamin E, 5-9 parts of glycerin, 0.3-0.7 parts of cetostearyl alcohol, 0.2-0.6 parts of triethanolamine, 20-30 parts of vaseline, and 0.1-0.2 parts of fluhexidine acetate.

[0011] Furthermore, the present invention provides a mole removal pharmaceutical composition comprising the following components in parts by weight: 19-21 parts of Brucea javanica, 16-18 parts of Patrinia scabra, 15-17 parts of Stemona japonica, 13-15 parts of Galla chinensis, 13-15 parts of Cnidium monnieri, 12-14 parts of Gentiana scabra, 11-13 parts of Cyperus rotundus, 8-10 parts of Phellodendron chinense, 4-6 parts of salicylic acid, 4-6 parts of borneol, 5-7 parts of vitamin E, 6-8 parts of glycerin, 0.4-0.6 parts of cetostearyl alcohol, 0.3-0.5 parts of triethanolamine, 23-27 parts of vaseline, and 0.12-0.18 parts of fluhexidine acetate.

[0012] Furthermore, the present invention provides a mole removal pharmaceutical composition comprising the following components in parts by weight: 20 parts of Brucea javanica, 17 parts of Patrinia scabra, 16 parts of Stemona japonica, 14 parts of Galla chinensis, 14 parts of Cnidium monnieri, 13 parts of Gentiana scabra, 12 parts of Cyperus rotundus, 9 parts of Phellodendron chinense, 5 parts of salicylic acid, 5 parts of borneol, 6 parts of vitamin E, 7 parts of glycerin, 0.5 parts of cetostearyl alcohol, 0.4 parts of triethanolamine, 25 parts of vaseline, and 0.15 parts of fluhexidine acetate.

[0013] A method for preparing a mole removal pharmaceutical composition comprises the following steps:

[0014] Step 1: weigh Brucea brucea, Patrinia scabra, Stemona tuber, Galla chinensis, Cnidium monnieri, Gentiana scabra, Cynanchum maculata, and Phellodendron chinense according to the above raw material formula;

[0015] Step 2: Grind, crush and screen the raw materials in step 1 in sequence, and then put the screened crushed raw materials into a mixer for uniform mixing to obtain a mixture;

[0016] Step 3: putting the mixture, salicylic acid, borneol, vitamin E, glycerin and vaseline into a reaction kettle to heat and react, and stirring at a constant speed during the heating reaction to obtain a mixed ointment;

[0017] Step 4: adding cetostearyl alcohol, triethanolamine and fluhexidine acetate to the mixed ointment, mixing evenly to obtain a semi-finished product;

[0018] Step 5: After the semi-finished product is cooled to room temperature, it is added into a sealed can for packaging.

[0019] Furthermore, in the step three, the heating temperature is 20-25° C., the heating time is 20-30 min, the stirring time is once every 4-5 min, and the stirring times are 5-6 times.

[0020] After adopting the above technical scheme, the beneficial effects of the present invention are as follows: providing a mole removal drug composition and a preparation method thereof, by selecting a variety of Chinese medicinal materials, after the mole is removed, the effects of anti-inflammatory and bactericidal, antipruritic and analgesic, moisturizing and sedative are achieved, and a barrier is formed with the surface layer of the skin to avoid fungal infection, thereby accelerating the recovery of the skin after the mole is removed. DETAILED DESCRIPTION

[0021] The technical solutions in the embodiments of the present invention are clearly and completely described below. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0022] Embodiment 1:

[0023] The invention discloses a mole removing medicine composition, which comprises the following components in parts by weight: 18 parts of Brucea javanica, 15 parts of Patrinia patriniae, 14 parts of Stemona tuberosa, 12 parts of Galla chinensis, 12 parts of Cnidium monnieri, 11 parts of Gentiana scabra, 10 parts of Cyperus rotundus, 6 parts of Phellodendron amurense, 3 parts of salicylic acid, 3 parts of borneol, 4 parts of vitamin E, 5 parts of glycerol, 0.3 parts of cetostearyl alcohol, 0.2 parts of triethanolamine, 20 parts of vaseline and 0.1 parts of fluhexidine acetate.

[0024] A method for preparing a mole removal pharmaceutical composition comprises the following steps:

[0025] Step 1: weigh Brucea brucea, Patrinia scabra, Stemona tuber, Galla chinensis, Cnidium monnieri, Gentiana scabra, Cynanchum maculata, and Phellodendron chinense according to the above raw material formula;

[0026] Step 2: Grind, crush and screen the raw materials in step 1 in sequence, and then put the screened crushed raw materials into a mixer for uniform mixing to obtain a mixture;

[0027] Step 3: putting the mixture, salicylic acid, borneol, vitamin E, glycerin and vaseline into a reaction kettle to heat and react, and stirring at a constant speed during the heating reaction to obtain a mixed ointment;

[0028] Step 4: adding cetostearyl alcohol, triethanolamine and fluhexidine acetate to the mixed ointment, mixing evenly to obtain a semi-finished product;

[0029] Step 5: After the semi-finished product is cooled to room temperature, it is added into a sealed can for packaging.

[0030] The heating temperature in step 3 is 20° C., the heating time is 20 min, the stirring time is once every 4 min, and the stirring times are 5 times.

[0031] Embodiment 2:

[0032] The invention discloses a mole removing medicine composition, which comprises the following components in parts by weight: 20 parts of Brucea javanica, 17 parts of Patrinia patriniae, 16 parts of Stemona tuberosa, 14 parts of Galla chinensis, 14 parts of Cnidium monnieri, 13 parts of Gentiana scabra, 12 parts of Cyperus rotundus, 9 parts of Phellodendron amurense, 5 parts of salicylic acid, 5 parts of borneol, 6 parts of vitamin E, 7 parts of glycerol, 0.5 parts of cetostearyl alcohol, 0.4 parts of triethanolamine, 25 parts of vaseline and 0.15 parts of fluhexidine acetate.

[0033] A method for preparing a mole removal pharmaceutical composition comprises the following steps:

[0034] Step 1: weigh Brucea brucea, Patrinia scabra, Stemona tuber, Galla chinensis, Cnidium monnieri, Gentiana scabra, Cynanchum maculata, and Phellodendron chinense according to the above raw material formula;

[0035] Step 2: Grind, crush and screen the raw materials in step 1 in sequence, and then put the screened crushed raw materials into a mixer for uniform mixing to obtain a mixture;

[0036] Step 3: putting the mixture, salicylic acid, borneol, vitamin E, glycerin and vaseline into a reaction kettle to heat and react, and stirring at a constant speed during the heating reaction to obtain a mixed ointment;

[0037] Step 4: adding cetostearyl alcohol, triethanolamine and fluhexidine acetate to the mixed ointment, mixing evenly to obtain a semi-finished product;

[0038] Step 5: After the semi-finished product is cooled to room temperature, it is added into a sealed can for packaging.

[0039] Furthermore, in the step three, the heating temperature is 22.5° C., the heating time is 25 min, the stirring time is once every 4.5 min, and the number of stirring times is 5 times.

[0040] Embodiment 3:

[0041] The invention discloses a mole removing medicine composition, which comprises the following components in parts by weight: 22 parts of Brucea javanica, 19 parts of Patrinia patriniae, 18 parts of Stemona tuberosa, 16 parts of Galla chinensis, 16 parts of Cnidium monnieri, 15 parts of Gentiana scabra, 14 parts of Cyperus rotundus, 12 parts of Phellodendron amurense, 7 parts of salicylic acid, 7 parts of borneol, 8 parts of vitamin E, 9 parts of glycerol, 0.7 parts of cetostearyl alcohol, 0.6 parts of triethanolamine, 30 parts of vaseline and 0.2 parts of fluhexidine acetate.

[0042] A method for preparing a mole removal pharmaceutical composition comprises the following steps:

[0043] Step 1: weigh Brucea brucea, Patrinia scabra, Stemona tuber, Galla chinensis, Cnidium monnieri, Gentiana scabra, Cynanchum maculata, and Phellodendron chinense according to the above raw material formula;

[0044] Step 2: Grind, crush and screen the raw materials in step 1 in sequence, and then put the screened crushed raw materials into a mixer for uniform mixing to obtain a mixture;

[0045] Step 3: putting the mixture, salicylic acid, borneol, vitamin E, glycerin and vaseline into a reaction kettle to heat and react, and stirring at a constant speed during the heating reaction to obtain a mixed ointment;

[0046] Step 4: adding cetostearyl alcohol, triethanolamine and fluhexidine acetate to the mixed ointment, mixing evenly to obtain a semi-finished product;

[0047] Step 5: After the semi-finished product is cooled to room temperature, it is added into a sealed can for packaging.

[0048] Furthermore, in the step three, the heating temperature is 25° C., the heating time is 30 min, the stirring time is once every 5 min, and the stirring times are 6 times.

[0049] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0050] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

[0051] The present invention and its implementation methods are described above, and such description is not restrictive, and the actual structure is not limited thereto. In short, if ordinary technicians in the field are inspired by it, without departing from the purpose of the invention, they can design structures and embodiments similar to the technical solution without creativity, which should all fall within the protection scope of the present invention.

Claims

1. A mole removal pharmaceutical composition, characterized in that: The invention comprises the following components in parts by weight: 18-22 parts of Brucea javanica, 15-19 parts of Patrinia scabra, 14-18 parts of Stemona japonica, 12-16 parts of Galla chinensis, 12-16 parts of Cnidium monnieri, 11-15 parts of Gentiana scabra, 10-14 parts of Cyperus rotundus, 6-12 parts of Phellodendron amurense, 3-7 parts of salicylic acid, 3-7 parts of borneol, 4-8 parts of vitamin E, 5-9 parts of glycerin, 0.3-0.7 parts of cetostearyl alcohol, 0.2-0.6 parts of triethanolamine, 20-30 parts of vaseline and 0.1-0.2 parts of fluhexidine acetate.

2. A mole removal pharmaceutical composition according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 19-21 parts of Brucea javanica, 16-18 parts of Patrinia scabra, 15-17 parts of Stemona japonica, 13-15 parts of Galla chinensis, 13-15 parts of Cnidium monnieri, 12-14 parts of Gentiana scabra, 11-13 parts of Cyperus rotundus, 8-10 parts of Phellodendron chinense, 4-6 parts of salicylic acid, 4-6 parts of borneol, 5-7 parts of vitamin E, 6-8 parts of glycerin, 0.4-0.6 parts of cetostearyl alcohol, 0.3-0.5 parts of triethanolamine, 23-27 parts of vaseline and 0.12-0.18 parts of fluhexidine acetate.

3. A mole removal pharmaceutical composition according to claim 2, characterized in that: The invention comprises the following components in parts by weight: 20 parts of Brucea javanica, 17 parts of Patrinia scabra, 16 parts of Stemona japonica, 14 parts of Galla chinensis, 14 parts of Cnidium monnieri, 13 parts of Gentiana scabra, 12 parts of Cyperus rotundus, 9 parts of Phellodendron amurense, 5 parts of salicylic acid, 5 parts of borneol, 6 parts of vitamin E, 7 parts of glycerin, 0.5 parts of cetostearyl alcohol, 0.4 parts of triethanolamine, 25 parts of vaseline and 0.15 parts of fluhexidine acetate.

4. A method for preparing the mole removal pharmaceutical composition according to any one of claims 1 to 3, characterized in that: The following steps are involved: Step 1: weigh Brucea brucea, Patrinia scabra, Stemona tuber, Galla chinensis, Cnidium monnieri, Gentiana scabra, Cynanchum maculata, and Phellodendron chinense according to the above raw material formula; Step 2: Grind, crush and screen the raw materials in step 1 in sequence, and then put the screened crushed raw materials into a mixer for uniform mixing to obtain a mixture; Step 3: putting the mixture, salicylic acid, borneol, vitamin E, glycerin and vaseline into a reaction kettle to heat and react, and stirring at a constant speed during the heating reaction to obtain a mixed ointment; Step 4: adding cetostearyl alcohol, triethanolamine and fluhexidine acetate to the mixed ointment, mixing evenly to obtain a semi-finished product; Step 5: After the semi-finished product is cooled to room temperature, it is added into a sealed can for packaging.

5. A mole removal pharmaceutical composition according to claim 4, characterized in that: In the step 3, the heating temperature is 20-25° C., the heating time is 20-30 min, the stirring time is once every 4-5 min, and the stirring times are 5-6 times.