Cleaning and separating device, cleaning and separating equipment and sample testing analyzer

Abstract

The invention relates to the technical field of in-vitro diagnosis automation equipment, and discloses a cleaning and separating device, cleaning and separating equipment and a sample testing analyzer. The cleaning and separating device comprises a base and a mounting plate, a driving part is arranged on the base, and a driving shaft of the driving part deviates from the base and is connected with the mounting plate; the driving device is used for driving the mounting plate to move up and down relative to the base, a plurality of mixers are arranged on the mounting plate at intervals, and the mixers are suitable for independently mixing the reaction containers. According to the cleaning and separating device, the driving part is adopted to control the mounting plate to move up and down so as to drive the plurality of mixers to move up and down synchronously, so that the mixers are close to or far away from the reaction container and mix the reaction container uniformly, the driving structure of the mixers is simplified, the control difficulty of the mixers is reduced, and the production efficiency is improved. Therefore, the working efficiency of cleaning and separating is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of in vitro diagnostic automation equipment, and in particular to a cleaning and separation device, a cleaning and separation equipment and a sample testing and analyzing instrument. Background Art

[0002] In order to ensure the accuracy of chemiluminescent immunoassay detection, it is necessary to use a cleaning and separation device to clean the magnetic beads in the reaction container to remove substances that are not bound to the solid phase antigens and antibodies and interfering substances that are non-specifically adsorbed to the solid phase carrier during the reaction, such as serum.

[0003] At present, the cleaning and separation device is generally composed of a magnetic adsorption mechanism, a rotating mechanism, a lifting drive mechanism, a cleaning mechanism, a mixing mechanism, etc. The reaction container is placed on the rotating mechanism, and the rotating mechanism drives the reaction container to rotate so that the reaction container moves to the cleaning liquid inlet position, the cleaning liquid discharge position, and the cleaning liquid mixing position. The magnetic adsorption mechanism adsorbs the magnetic beads so that the magnetic beads are attached to the inner side of the bottom of the reaction container. When the reaction container moves to the cleaning liquid inlet position and the cleaning liquid discharge position, the cleaning mechanism performs the liquid inlet and liquid discharge actions. When the reaction container moves to the cleaning liquid mixing position, the mixing mechanism performs the mixing action.

[0004] The mixing mechanism is generally provided with a plurality of mixers to achieve multiple mixing of the reaction container. However, each mixer requires an independent driving mechanism, which makes the control of the mixing mechanism difficult and the manufacturing cost high. Summary of the invention

[0005] In view of this, the present invention provides a cleaning and separation device, a cleaning and separation equipment and a sample testing analyzer to solve the problem that each mixer of the mixing mechanism requires an independent driving mechanism, resulting in greater control difficulty and higher manufacturing cost.

[0006] In a first aspect, the present invention provides a cleaning and separation device, comprising: a base and a mounting plate, wherein a driving member is provided on the base, a driving shaft of the driving member is away from the base and connected to the mounting plate, and is used to drive the mounting plate to move up and down relative to the base, and a plurality of mixers are provided on the mounting plate at intervals, each of the mixers being suitable for independently mixing a reaction container.

[0007] Beneficial effects: The cleaning and separation device of the present invention adopts a driving component to control the up and down movement of the mounting plate, so as to simultaneously drive multiple mixers to move up and down synchronously, so that the mixers are close to or away from the reaction container and mix the reaction container, which simplifies the driving structure of the mixer and reduces the control difficulty of the mixer, thereby facilitating improving the working efficiency of the cleaning and separation.

[0008] In an optional embodiment, at least one guide rail assembly is further provided between the base and the mounting plate, and at least one of the guide rail assemblies slides in an up-down direction.

[0009] Beneficial effect: by arranging at least one guide rail assembly between the base and the mounting plate, the shaking of the mounting plate can be reduced, and the stability of the up and down movement of the mounting plate can be ensured, thereby ensuring that multiple mixers rise and fall synchronously.

[0010] In an optional embodiment, the guide rail assembly includes:

[0011] A support plate, fixedly mounted on the top of the base and spaced apart from the driving member, with a slide rail extending in an up-and-down direction on one side surface;

[0012] The sliding plate has an upper end fixedly connected to the mounting plate and a lower end provided with a sliding block matched with the sliding rail.

[0013] Beneficial effects: The support plate is used to support the sliding plate and the mounting plate, and the sliding plate slides up and down relatively with the mounting plate. The structure is simple and convenient to manufacture and use.

[0014] In an optional embodiment, a bottom plate is provided on the top of the base, the bottom plate is spaced apart from the mounting plate, and the support plate and the driving member are both fixed on the top surface of the bottom plate.

[0015] Beneficial effect: By fixing the support plate and the driving member on the top surface of the bottom plate, the flatness of the support plate and the driving member can be ensured, and the plurality of mixers can be further ensured to be located on the same horizontal plane.

[0016] In a second aspect, the present invention further provides a cleaning and separation device, comprising:

[0017] The above-mentioned cleaning and separation device, the top of the base is also provided with a support shaft;

[0018] A magnetic chuck is sleeved on the support shaft and is surrounded by magnetic parts, wherein the magnetic parts are suitable for absorbing the magnetic beads in the reaction container;

[0019] The rotating mechanism comprises a rotating drive member and a rotating disk, wherein the rotating disk is movably sleeved on the supporting shaft, and a plurality of supporting parts are provided at intervals on the peripheral side of the end surface, each of the supporting parts is suitable for carrying a reaction container, and the rotating drive member is connected to the rotating disk and is used to drive the rotating disk to rotate to a specified position;

[0020] The cleaning mechanism is arranged on the supporting shaft and located at the upper end of the rotating disk, and is used for sucking and injecting liquid into the reaction container.

[0021] Beneficial effect: Because the cleaning and separation equipment includes the above-mentioned cleaning and separation device, it has the same effect as the cleaning and separation device, that is, a driving member is used to control the up and down movement of the mounting plate to realize simultaneous driving of multiple mixers to move up and down synchronously, so that the mixers are close to or away from the reaction container and mix the reaction container, which simplifies the driving structure of the mixer and reduces the control difficulty of the mixer, thereby facilitating improving the working efficiency of the cleaning and separation.

[0022] In an optional embodiment, the cleaning mechanism includes:

[0023] A liquid injection disk, sleeved on the support shaft and located at the upper end of the rotating disk, wherein the liquid injection disk is provided with a plurality of liquid injection portions along the circumference corresponding to the support portion;

[0024] A lifting drive and a plurality of liquid suction parts, wherein the lifting drive is disposed on the top of the liquid injection tray, the lifting drive is connected to the plurality of liquid suction parts and is used to drive the plurality of liquid suction parts to lift and lower, the plurality of liquid suction parts correspond to the supporting parts and are suitable for passing through the liquid injection tray to enter and exit the reaction container.

[0025] Beneficial effect: cleaning liquid is injected into the reaction container through multiple liquid injection parts, and multiple liquid suction parts are driven to rise and fall through the lifting driving parts to realize the liquid suction action.

[0026] In an optional embodiment, the cleaning and separation equipment is respectively provided with three-stage liquid filling positions, three-stage magnetic suction positions and three-stage liquid suction positions, each stage of the magnetic suction positions is composed of a plurality of the magnetic parts, and each stage of the liquid suction positions is arranged above the last magnetic part of each stage of the magnetic suction positions.

[0027] Beneficial effect: Setting three-stage liquid injection positions, three-stage magnetic suction positions and three-stage liquid suction positions can clean and separate the magnetic beads in the reaction container three times, and the cleaning and separation process is more thorough. Setting each liquid suction position above the last magnetic piece of each magnetic suction position can save the space occupied by the three liquid suction positions, and at the same time facilitate the rapid suction of waste liquid after the magnetic suction is completed.

[0028] In an optional embodiment, the cleaning and separation equipment is provided with an entry and exit position, a first-stage liquid injection position, a first-stage magnetic suction position, a first-stage liquid suction position, a second-stage liquid injection position, a second-stage magnetic suction position, a second-stage liquid suction position, a third-stage liquid injection position, a third-stage magnetic suction position, a third-stage liquid suction position and a substrate liquid injection position in sequence along the circumferential direction.

[0029] Beneficial effects: The cleaning and separation equipment is provided with various operating positions along the circumference, and the rotating disk can achieve three cleaning and separations by rotating one circle, with a simple structure and a small volume.

[0030] In an optional embodiment, the substrate injection level includes a first substrate injection level and a second substrate injection level.

[0031] Beneficial effect: By setting the first substrate injection position and the second substrate injection position, the substrate can be injected according to different systems, and the cleaning and separation of reaction containers of various systems are compatible, thereby increasing the scope of application.

[0032] In a third aspect, the present invention further provides a sample testing analyzer, comprising the above-mentioned cleaning and separation device.

[0033] Beneficial effects: Since the sample testing analyzer includes the cleaning and separation device, it has the same effects as the cleaning and separation device and will not be described in detail here. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] In order to more clearly illustrate the specific implementation methods of the present invention or the technical solutions in the prior art, the drawings required for use in the specific implementation methods or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are some implementation methods of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0035] Figure 1 A schematic structural diagram of a cleaning and separation device according to an embodiment of the present invention;

[0036] Figure 2 It is a structural schematic diagram of a cleaning and separation device according to an embodiment of the present invention;

[0037] Figure 3 It is a first partial structural schematic diagram of a cleaning and separation device according to an embodiment of the present invention;

[0038] Figure 4 A second partial structural schematic diagram of a cleaning and separation device according to an embodiment of the present invention;

[0039] Figure 5 A third partial structural schematic diagram of a cleaning and separation device according to an embodiment of the present invention;

[0040] Figure 6 It is a partial top view schematic diagram of a cleaning and separation device according to an embodiment of the present invention.

[0041] Description of reference numerals:

[0042] 1. Base; 2. Mounting plate; 3. Driving member; 301. Driving shaft; 4. Mixer; 5. Guide rail assembly; 501. Support plate; 502. Sliding plate; 6. Bottom plate; 7. Flatness fixture; 8. Mounting fixture; 9. Support shaft; 10. Magnetic chuck; 11. Rotating mechanism; 1101. Rotating driving member; 1102. Rotating disk; 12. Cleaning mechanism; 1201. Liquid injection disk; 1202. Liquid injection part; 12021. First substrate liquid injection part; 12022. Second substrate liquid injection part; 1203. Lifting driving member; 1204. Liquid suction part; 13. Reaction container;

[0043] 101, entry and exit position; 102, first-stage liquid injection position; 103, first-stage magnetic suction position; 104, first-stage liquid suction position; 105, second-stage liquid injection position; 106, second-stage magnetic suction position; 107, second-stage liquid suction position; 108, third-stage liquid injection position; 109, third-stage magnetic suction position; 110, third-stage liquid suction position; 111, first substrate liquid injection position; 112, second substrate liquid injection position. DETAILED DESCRIPTION

[0044] In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative work are within the scope of protection of the present invention.

[0045] Combine the following Figures 1 to 6 , describing an embodiment of the present invention.

[0046] According to an embodiment of the present invention, on the one hand, Figure 1 and Figure 2 As shown, a cleaning and separation device is provided, including: a base 1 and a mounting plate 2, a driving member 3 is provided on the top of the base 1, a driving shaft 301 of the driving member 3 is away from the base 1 and connected to the mounting plate 2, and is used to drive the mounting plate 2 to move up and down relative to the base 1, and a plurality of mixers 4 are provided on the mounting plate 2 at intervals, and each mixer 4 is suitable for independently mixing the reaction container 13.

[0047] It can be seen that the cleaning and separation device provided in the embodiment of the present invention adopts the driving member 3 to control the up and down movement of the mounting plate 2, so as to realize the synchronous up and down movement of multiple mixers 4 at the same time, so that the mixer 4 is close to or away from the reaction container 13, and the reaction container 13 is mixed, which simplifies the driving structure of the mixer 4 and reduces the control difficulty of the mixer 4, thereby facilitating improving the working efficiency of the cleaning and separation.

[0048] Compared with the conventional method in which each mixer 4 needs to be provided with a corresponding driving member 3 to control the mixer 4 to move up and down, the embodiment of the present invention reduces the number of driving members 3 used, makes it easier to control the mixer 4 to move up and down, and simplifies the structure.

[0049] It should be noted that the embodiment of the present invention does not limit the structure of the driving member 3, and any existing structure can be selected as needed, as long as the driving member 3 can drive the mounting plate 2 to move up and down relative to the base 1. For example, the driving member 3 is a telescopic motor, and the driving shaft 301 of the driving member 3 drives the mounting plate 2 to move up and down relative to the base 1 by telescoping. Alternatively, the driving member 3 is a screw motor, and the driving shaft 301 of the driving member 3 is a screw, which is threadedly connected to the mounting plate 2, and the screw motor is rotated to drive the mounting plate 2 to move up and down relative to the base 1.

[0050] In one embodiment, Figure 2 As shown, at least one guide rail assembly 5 is further provided between the base 1 and the mounting plate 2, and the at least one guide rail assembly 5 slides in the up-down direction. By providing at least one guide rail assembly 5 between the base 1 and the mounting plate 2, the shaking of the mounting plate 2 can be reduced, and the stability of the up-down movement of the mounting plate 2 can be ensured, thereby ensuring that the multiple mixers 4 rise and fall synchronously.

[0051] It should be noted that the embodiment of the present invention does not limit the structure of the guide rail assembly 5, and any existing structure can be selected as needed. In addition, the number of the guide rail assembly 5 is not limited, and one, two or more than two can be selected.

[0052] Further, in one embodiment, if Figure 2 As shown, the guide rail assembly 5 mainly includes: a support plate 501 and a sliding plate 502. The support plate 501 is fixedly arranged on the top of the base 1 and is spaced apart from the driving member 3. A slide rail extending in the up-down direction is arranged on one side surface. The upper end of the slide plate 502 is fixedly connected to the mounting plate 2, and a slider matching the slide rail is arranged at the lower end. The support plate 501 is used to support the slide plate 502 and the mounting plate 2. The slide plate 502 slides up and down relatively with the mounting plate 2. The structure is simple and convenient to manufacture and use.

[0053] Further, in one embodiment, if Figure 2 As shown, a pair of guide rail assemblies 5 are provided, and the pair of guide rail assemblies 5 are respectively spaced apart on both sides of the driving member 3, and form a quasi-triangle with the driving member 3. By providing a pair of guide rail assemblies 5, and the guide rail assemblies 5 are respectively spaced apart on both sides of the driving member 3, and form a quasi-triangle with the driving member 3, the movement stability of the mounting plate 2 can be further improved.

[0054] In one embodiment, a flatness fixture 7 is further provided on the top of the mounting plate 2, and the flatness fixture 7 is used to adjust the position of the mounting plate 2 so that the multiple mixers 4 are located at the same horizontal plane. By adjusting the position of the mounting plate 2 by the flatness fixture 7, it is possible to ensure that the multiple mixers 4 are located at the same horizontal plane and rise and fall synchronously, so as to improve the uniformity of multiple mixing. Compared with the staggered arrangement, the multiple mixers 4 located at the same horizontal plane can make better use of space, facilitate the overall layout design and have stronger anti-interference performance.

[0055] In one embodiment, Figure 2 As shown, a bottom plate 6 is provided on the top of the base 1, the bottom plate 6 is spaced apart from the mounting plate 2, and the support plate 501 and the driving member 3 are fixedly arranged on the top surface of the bottom plate 6. The support plate 501 and the driving member 3 are fixedly arranged on the top surface of the bottom plate 6, so that the flatness of the support plate 501 and the driving member 3 can be ensured, and the multiple mixers 4 can be further ensured to be located on the same horizontal plane.

[0056] Furthermore, the base 1 , the bottom plate 6 and the mounting plate 2 are all machined parts, which have high processing accuracy and stability and can effectively ensure the flatness and dimensional accuracy of the surfaces of the bottom plate 6 and the mounting plate 2 .

[0057] It should be noted that the embodiment of the present invention does not limit the fixed connection method of the support plate 501, the driving member 3 and the base plate 6. A detachable fixing method, such as screw connection, can be adopted as needed to facilitate installation and maintenance. A fastening connection method, such as welding connection, can also be adopted, which has a strong structural stability.

[0058] In one embodiment, Figure 2 As shown, a plurality of mixers 4 are provided at intervals on the top of the mounting plate 2. The mixer 4 is fixed on the top of the mounting plate 2, and the mixing is stable, which is conducive to the mixer 4 approaching or moving away from the reaction container 13, and mixing the reaction container 13. The mixer 4 can be adjusted in level by the mounting fixture 8 so that the plurality of mixers 4 are located on the same horizontal plane, and the mounting fixture 8 is removed after the adjustment is completed.

[0059] According to an embodiment of the present invention, on the other hand, Figure 1 As shown, a cleaning and separation device is also provided, which mainly includes: a cleaning and separation device, a magnetic suction cup 10, a rotating mechanism 11 and a cleaning mechanism 12.

[0060] Furthermore, a support shaft 9 is also provided on the top of the base 1. The magnetic suction cup 10 is sleeved on the support shaft 9, and is surrounded by magnetic parts, which are suitable for adsorbing the magnetic beads in the reaction container 13. The rotating mechanism 11 mainly includes a rotating drive member 1101 and a rotating disk 1102. The rotating disk 1102 is movably sleeved on the support shaft 9, and a plurality of support parts are spaced apart on the circumferential side of the end face, each of which is suitable for carrying the reaction container 13. The rotating drive member 1101 is connected to the rotating disk 1102, and is used to drive the rotating disk 1102 to rotate to a specified position. The cleaning mechanism 12 is arranged on the support shaft 9 and at the upper end of the rotating disk 1102, and is used to absorb and inject liquid into the reaction container 13.

[0061] Because the cleaning and separation equipment includes the above-mentioned cleaning and separation device, it has the same effect as the cleaning and separation device, that is, the driving member 3 is used to control the up and down movement of the mounting plate 2 to achieve simultaneous driving of multiple mixers 4 to move up and down synchronously, so that the mixers 4 are close to or away from the reaction container 13, and the reaction container 13 is mixed, which simplifies the driving structure of the mixer 4 and reduces the control difficulty of the mixer 4, thereby facilitating improving the working efficiency of the cleaning and separation.

[0062] Specifically, a plurality of through holes are provided at intervals on the circumference of the rotating disk 1102, and the through holes serve as a support portion and load the reaction container 13. The support shaft 9 is mounted on the bottom plate 6, and the magnetic suction cup 10 is fixedly sleeved on the support shaft 9. The rotating disk 1102 can rotate periodically relative to the magnetic suction cup 10 and the cleaning mechanism 12. The rotating disk 1102 is driven to rotate by the rotating driving member 1101, and the reaction container 13 is transported to a designated position. For example, it is transported to the corresponding position of the magnetic member, and the magnetic beads in the reaction container 13 are adsorbed by the magnetic member, so that the magnetic beads are attached to the bottom of the reaction container 13. The magnetic member can be a plurality of permanent magnets embedded around the magnetic suction cup 10, or it can be a magnetic ring sleeved on the outer periphery of the magnetic suction cup 10.

[0063] In one embodiment, Figures 3 to 5 As shown, the cleaning mechanism 12 mainly includes: a liquid injection tray 1201, a lifting drive 1203 and a plurality of liquid suction parts 1204. The liquid injection tray 1201 is sleeved on the support shaft 9 and is located at the upper end of the rotating disk 1102. The liquid injection tray 1201 is provided with a plurality of liquid injection parts 1202 corresponding to the supporting part along the circumference. The lifting drive 1203 is arranged on the top of the liquid injection tray 1201. The lifting drive 1203 is connected with the plurality of liquid suction parts 1204 and is used to drive the plurality of liquid suction parts 1204 to rise and fall. The plurality of liquid suction parts 1204 correspond to the supporting part and are suitable for passing through the liquid injection tray 1201 to enter and exit the reaction container 13. The cleaning liquid is injected into the reaction container 13 through the plurality of liquid injection parts 1202, and the plurality of liquid suction parts 1204 are driven to rise and fall by the lifting drive 1203 to realize the liquid suction action.

[0064] Specifically, the liquid injection part 1202 includes a liquid injection needle and a syringe connected to each other, which are used to realize the liquid injection action. The liquid suction part 1204 includes a liquid suction needle and a liquid suction pump connected to each other, and the liquid suction pump provides power to the liquid suction needle to realize the liquid suction action. The lifting drive part 1203 can adopt a screw motor to realize the lifting action. For example, the bottom of the screw motor is connected to the liquid injection plate 1201, and the top is connected to the liquid suction plate. A guide rail is also provided between the liquid suction plate and the liquid injection plate 1201, and the liquid suction part 1204 is fixedly arranged on the liquid suction plate. After the screw motor rotates, the liquid suction plate is driven to move up and down, thereby driving the liquid suction part 1204 to move up and down.

[0065] Furthermore, in one embodiment, the cleaning and separation equipment is respectively provided with three-stage liquid injection positions, three-stage magnetic suction positions and three-stage liquid suction positions, each stage of the magnetic suction position is composed of a plurality of magnetic parts, and each stage of the liquid suction position is provided above the last magnetic part of each stage of the magnetic suction position. By providing three-stage liquid injection positions, three-stage magnetic suction positions and three-stage liquid suction positions, the magnetic beads in the reaction container 13 can be cleaned and separated three times, and the cleaning and separation process is more thorough. By providing each stage of the liquid suction position above the last magnetic part of each stage of the magnetic suction position, the space occupied by the three liquid suction positions can be saved, and at the same time, it is beneficial to quickly suck out the waste liquid after the magnetic suction is completed.

[0066] It should be noted that the embodiment of the present invention does not limit the number of the liquid suction part 1204 and the liquid injection part 1202, and two, three or more than three can be selected as needed.

[0067] In one embodiment, Figure 6 As shown, the cleaning and separation equipment has three-stage separation and cleaning positions, and is provided with an inlet and outlet position 101, a first-stage liquid injection position 102, a first-stage magnetic suction position 103, a first-stage liquid suction position 104, a second-stage liquid injection position 105, a second-stage magnetic suction position 106, a second-stage liquid suction position 107, a third-stage liquid injection position 108, a third-stage magnetic suction position 109, a third-stage liquid suction position 110, and a substrate liquid injection position in sequence along the circumferential direction. The cleaning and separation equipment is provided with various operating positions along the circumferential direction, and the rotating disk 1102 can achieve three cleaning and separations by rotating one circle, and has a simple structure and a small volume.

[0068] Further, in one embodiment, the substrate injection level includes a first substrate injection level 111 and a second substrate injection level 112. By setting the first substrate injection level 111 and the second substrate injection level 112, substrates can be injected according to different systems, and the cleaning and separation of the reaction container 13 of various systems can be compatible, thereby increasing the scope of application.

[0069] Specifically, the plurality of injection parts 1202 respectively constitute a first-stage injection level 102, a second-stage injection level 105, a third-stage injection level 108, a first substrate injection level 111, and a second substrate injection level 112. Figure 5As shown, the plurality of injection parts 1202 include a first substrate injection part 12021 and a second substrate injection part 12022. The first substrate injection part 12021 serves as a first substrate injection position 111, and the second substrate injection part 12022 serves as a second substrate injection position 112.

[0070] Furthermore, in one embodiment, the liquid suction position is arranged on the magnetic suction position. The liquid suction position is arranged on the magnetic suction position, which can save the space occupied by the liquid suction position and facilitate the rapid suction of waste liquid after the magnetic suction is completed.

[0071] Specifically, the first-stage liquid suction position 104 is disposed on the first-stage magnetic suction position 103 , the second-stage liquid suction position 107 is disposed on the second-stage magnetic suction position 106 , and the third-stage liquid suction position 110 is disposed on the third-stage magnetic suction position 109 .

[0072] The working principle of the embodiment of the present invention is as follows:

[0073] At the in-and-out position 101, the reaction container 13 is installed, and then the rotating disk 1102 drives the reaction container 13 to rotate periodically. The reaction container 13 first reaches the bottom of the first-stage liquid injection position 102, and the cleaning liquid injection position injects the cleaning liquid into the reaction container 13. Then the rotating disk 1102 drives the reaction container 13 to the first-stage magnetic suction position 103, and the magnetic beads are adsorbed to the inner wall of the reaction container 13 under the action of the magnetic field. After that, the rotating disk 1102 drives the reaction container 13 to the bottom of the liquid suction part 1204, that is, the first-stage liquid suction position 104, and the lifting drive 1203 drives the multiple liquid suction parts 1204 to descend and absorb the waste liquid in the reaction container 13, and then rises and leaves the reaction container 13.

[0074] The reaction container 13 continues to enter below the second-stage liquid injection position 105, and the cleaning liquid injection position injects the cleaning liquid into the reaction container 13. Then, the rotating disk 1102 drives the reaction container 13 to the second-stage magnetic absorption position 106, and the magnetic beads are adsorbed to the inner wall of the reaction container 13 under the action of the magnetic field. After that, the rotating disk 1102 drives the reaction container 13 to the bottom of the liquid absorption part 1204, that is, the second-stage liquid absorption position 107, and the lifting drive 1203 drives the multiple liquid absorption parts 1204 to descend and absorb the waste liquid in the reaction container 13, and then rises and leaves the reaction container 13.

[0075] The reaction container 13 continues to enter below the third-stage liquid injection position 108, and the cleaning liquid injection position injects the cleaning liquid into the reaction container 13. Then, the rotating disk 1102 drives the reaction container 13 to the third-stage magnetic absorption position 109, and the magnetic beads are adsorbed to the inner wall of the reaction container 13 under the action of the magnetic field. After that, the rotating disk 1102 drives the reaction container 13 to the bottom of the liquid absorption part 1204, that is, the third-stage liquid absorption position 110, and the lifting drive 1203 drives the multiple liquid absorption parts 1204 to descend and absorb the waste liquid in the reaction container 13, and then rises and leaves the reaction container 13.

[0076] Finally, the reaction container 13 enters the first substrate injection position 111 and the second substrate injection position 112 in sequence, and the reaction substrate is injected according to the reaction system. For example, the AP (phosphatase) system and the AE (acridinium ester) system inject the substrate or the excitation liquid into the first substrate injection part 12021, and the second substrate injection part 12022 does not operate. The HRP (horseradish peroxidase) system injects different substrates into the first substrate injection part 12021 and the second substrate injection part 12022 respectively. The substrates of different systems need to be selected and set according to the actual situation, and the embodiments of the present invention do not impose too many restrictions on this.

[0077] According to another aspect of an embodiment of the present invention, a sample testing analyzer is provided, comprising a cleaning and separation device.

[0078] Because the sample testing analyzer includes a cleaning and separation device, which has the same effect as the cleaning and separation device, it will not be described in detail here.

[0079] Although the embodiments of the present invention have been described in conjunction with the accompanying drawings, those skilled in the art may make various modifications and variations without departing from the spirit and scope of the present invention, and such modifications and variations are all within the scope defined by the appended claims.

Claims

1. A cleaning and separation device, characterized in that: include: A base (1) and a mounting plate (2), wherein the base (1) is provided with a driving member (3), a driving shaft (301) of the driving member (3) is away from the base (1) and connected to the mounting plate (2), and is used to drive the mounting plate (2) to move up and down relative to the base (1), and a plurality of mixers (4) are arranged at intervals on the mounting plate (2), and each of the mixers (4) is suitable for independently mixing a reaction container (13).

2. The cleaning and separation device according to claim 1, characterized in that: At least one guide rail assembly (5) is also provided between the base (1) and the mounting plate (2), and at least one guide rail assembly (5) slides in an up-down direction.

3. The cleaning and separation device according to claim 2, characterized in that: The guide rail assembly (5) comprises: A support plate (501) is fixedly mounted on the top of the base (1) and spaced apart from the driving member (3), and has a slide rail extending in an up-down direction on one side surface; The sliding plate (502) has an upper end fixedly connected to the mounting plate (2) and a lower end provided with a sliding block that cooperates with the sliding rail.

4. The cleaning and separation device according to claim 3, characterized in that: A bottom plate (6) is provided on the top of the base (1), the bottom plate (6) is spaced apart from the mounting plate (2), and the support plate (501) and the driving member (3) are both fixedly mounted on the top surface of the bottom plate (6).

5. A cleaning and separation device, characterized in that: include: The cleaning and separation device according to any one of claims 1 to 4, wherein a support shaft (9) is further provided on the top of the base (1); A magnetic suction cup (10) is sleeved on the support shaft (9) and is provided with magnetic parts around it, wherein the magnetic parts are suitable for absorbing the magnetic beads in the reaction container (13); The rotating mechanism (11) comprises a rotating drive member (1101) and a rotating disk (1102), wherein the rotating disk (1102) is movably sleeved on the supporting shaft (9), and a plurality of supporting portions are provided at intervals on the circumference of the end surface, each of the supporting portions being suitable for carrying a reaction container (13), and the rotating drive member (1101) is connected to the rotating disk (1102) and is used to drive the rotating disk (1102) to rotate to a specified position; The cleaning mechanism (12) is arranged on the supporting shaft (9) and located at the upper end of the rotating disk (1102), and is used for sucking and injecting liquid into the reaction container (13).

6. The cleaning and separation equipment according to claim 5, characterized in that: The cleaning mechanism (12) comprises: A liquid injection disk (1201) is sleeved on the support shaft (9) and located at the upper end of the rotating disk (1102), and the liquid injection disk (1201) is provided with a plurality of liquid injection portions (1202) along the circumference thereof corresponding to the support portion; A lifting drive member (1203) and a plurality of liquid suction parts (1204), wherein the lifting drive member (1203) is disposed on the top of the liquid injection plate (1201), and the lifting drive member (1203) is connected to the plurality of liquid suction parts (1204) for driving the plurality of liquid suction parts (1204) to lift and lower, and the plurality of liquid suction parts (1204) correspond to the supporting part and are suitable for passing through the liquid injection plate (1201) and entering and exiting the reaction container (13).

7. The cleaning and separation equipment according to claim 6, characterized in that: The cleaning and separation equipment is respectively provided with three-stage liquid filling positions, three-stage magnetic suction positions and three-stage liquid suction positions, each stage of the magnetic suction positions is composed of a plurality of the magnetic parts, and each stage of the liquid suction positions is arranged above the last magnetic part of each stage of the magnetic suction positions.

8. The cleaning and separation equipment according to claim 7, characterized in that: The cleaning and separation device is provided with an entry and exit position (101), a first-stage liquid injection position (102), a first-stage magnetic suction position (103), a first-stage liquid suction position (104), a second-stage liquid injection position (105), a second-stage magnetic suction position (106), a second-stage liquid suction position (107), a third-stage liquid injection position (108), a third-stage magnetic suction position (109), a third-stage liquid suction position (110), and a substrate liquid injection position in sequence along the circumferential direction.

9. The cleaning and separation equipment according to claim 8, characterized in that: The substrate injection position comprises a first substrate injection position (111) and a second substrate injection position (112).

10. A sample testing analyzer, characterized in that: The cleaning and separation device comprises the cleaning and separation device according to any one of claims 5 to 9.

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