Cleaning method for quick connector of dialyzer

Abstract

A dialyzer quick connector cleaning method comprises the following steps that S1, cleaning liquid is prepared, specifically, the cleaning liquid is prepared from, by weight, 45 parts of citric acid, 3 parts of tartaric acid, 4 parts of urotropine, 1 part of fatty alcohol-polyoxyethylene ether and the balance deionized water; s2, putting the quick connector and the cleaning solution into a cleaning tank of an ultrasonic cleaning machine, and adding reverse osmosis water for dilution to enable the concentration ratio of citric acid to be 5%; a heating module and an ultrasonic generation module are started, the liquid is heated to 85-95 DEG C, ultrasonic cleaning is conducted on the quick connector for 10 min, and waste liquid is discharged after cleaning; s3, reverse osmosis water is injected into the cleaning tank to clean the quick connector, and then waste liquid is discharged; s4, sodium hypochlorite disinfectant and reverse osmosis water are added into the cleaning tank for dilution, the concentration ratio of sodium hypochlorite is made to be 0.1%, an ultrasonic generation module is started at the normal temperature, ultrasonic cleaning is conducted on the quick connector for 10 min, and waste liquid is discharged after cleaning; s5, reverse osmosis water is injected into the cleaning tank to clean the quick connector, and then waste liquid is discharged; and S6, taking out the quick connector for use.

Description

Technical Field

[0001] The invention belongs to the technical field of medical device cleaning, and in particular relates to a dialyzer quick connector cleaning method. Background Art

[0002] The quick connector is a key component that connects the hemodialysis device and the hemodialysis machine. During use, components such as creatinine, urea, nitrogen, glucose in the blood will firmly adhere to the inner wall of the quick connector, and calcium and magnesium crystal salts will form crystals due to the deposition of dialysate components, resulting in a poor seal at the quick connector connection position, causing microbial growth and posing a serious threat to patient health. Therefore, the quick connector needs to be cleaned regularly.

[0003] In the prior art, the quick connector is cleaned by alcohol immersion. This method can only remove surface dirt, but has poor effect on deep-seated blood contamination and crystallized salt dirt, and it is difficult to effectively kill various microorganisms. In view of this, it is necessary to design a method for comprehensive cleaning and disinfection of dialyzer quick connectors. Summary of the invention

[0004] Technical issues solved The present invention provides a dialyzer quick connector cleaning method, which can effectively remove dirt on the dialyzer quick connector, completely kill various microorganisms, and improve the cleaning effect and safety.

[0005] Technical Solution To achieve the above object, the present invention provides the following technical solutions: S1. Configure the cleaning solution, the cleaning solution is composed of the following components in parts by weight: 20-50 parts of citric acid, 3-5 parts of fruit acid, 3.6-5 parts of urotropine, 0.75-2 parts of fatty alcohol polyoxyethylene ether, and the balance is deionized water; S2. Preliminary cleaning: placing the quick connector to be cleaned into the cleaning tank of an ultrasonic cleaning machine, and adding cleaning liquid and reverse osmosis water to the cleaning tank for dilution, so that the concentration of citric acid is 2-5%; starting the heating module and ultrasonic generating module of the ultrasonic cleaning machine, heating the liquid in the cleaning tank to 85-95° C., and performing ultrasonic cleaning on the quick connector for 5-15 minutes, and discharging the waste liquid in the cleaning tank after cleaning; S3. Initial flushing: inject reverse osmosis water into the cleaning tank to flush the quick connector, and discharge the waste liquid in the cleaning tank after cleaning; S4. Secondary cleaning, adding sodium hypochlorite disinfectant and reverse osmosis water to the cleaning tank for dilution, so that the concentration of sodium hypochlorite is 0.05-0.2%, starting the ultrasonic generator module at room temperature, and performing ultrasonic cleaning for 5-15 minutes on the quick connector for disinfection, and discharging the waste liquid in the cleaning tank after disinfection; S5. Secondary flushing: inject reverse osmosis water into the cleaning tank to flush the quick connector, and discharge the waste liquid in the cleaning tank after cleaning; S6. Take out the quick connector from the cleaning tank, dry it, and then reinstall it for use.

[0006] Preferably, in steps S2 to S5, the frequency of the ultrasonic generating module is 40-60 kHz, and the power density is 0.5-1.5 W / cm².

[0007] Preferably, in step S2, the ultrasonic cleaning machine also includes a first delivery pump, a water tank for storing reverse osmosis water and a first liquid storage bottle for storing cleaning liquid. The ultrasonic cleaning machine starts the first delivery pump according to a preset program of its own control system, so that the first delivery pump pumps an appropriate amount of reverse osmosis water and cleaning liquid into the cleaning tank for automatic dilution, ensuring that the proportion of citric acid in the diluted liquid is 2-5%.

[0008] Preferably, in step S4, the ultrasonic cleaning machine further includes a second delivery pump and a second liquid storage bottle for storing sodium hypochlorite disinfectant. The ultrasonic cleaning machine starts the second delivery pump according to a preset program of its own control system, so that the second delivery pump pumps an appropriate amount of reverse osmosis water and sodium hypochlorite disinfectant into the cleaning tank for automatic dilution, ensuring that the proportion of sodium hypochlorite in the diluted liquid is 0.05-0.2%.

[0009] Preferably, in step S3 and step S5, when flushing the quick connector, the ultrasonic generating module can be turned on to perform ultrasonic cleaning on the quick connector for 5-10 minutes to remove residual cleaning solution / sodium hypochlorite disinfectant and dirt particles on the quick connector.

[0010] Preferably, in steps S2 to S5, when discharging the waste liquid in the cleaning tank, the ultrasonic generating module can be turned on to perform ultrasonic cleaning on the quick connector for 5-10 minutes to ensure that the residual dirt and liquid in the cleaning tank are completely discharged.

[0011] Preferably, in step S6, after the quick connector is taken out, it can be naturally drained in a sterile environment or quickly dried in a dryer.

[0012] (III) Beneficial effects The present invention provides a dialyzer quick connector cleaning method. By means of ultrasonic cavitation effect and the characteristic of citric acid dissolving calcium and magnesium crystal salt, various dirt on the dialyzer quick connector can be completely and efficiently removed and disinfected. By means of fruit acid, the acidification effect can be enhanced, and rust can be removed more effectively. Meanwhile, by means of hexamethylenetetramine and fatty alcohol polyoxyethylene ether, the cleaning effect can be further improved, and damage to metal, plastic and rubber parts of the quick connector can be reduced, thereby extending the service life of the quick connector. By means of the bactericidal characteristic of sodium hypochlorite, the quick connector is secondary disinfected at room temperature, so as to more effectively kill various microorganisms and improve the use safety of the quick connector. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. In the accompanying drawings: Figure 1 A flow chart of the cleaning steps of the present invention is shown. DETAILED DESCRIPTION

[0014] The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments of the present application, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present application.

[0015] Embodiment 1 A method for cleaning a dialyzer quick connector comprises the following steps: S1. Configure the cleaning solution, the cleaning solution is composed of the following components by weight: 20 parts of citric acid, 3 parts of fruit acid, 3.6 parts of urotropine, 0.75 parts of fatty alcohol polyoxyethylene ether, and the balance is deionized water; S2. Preliminary cleaning: place one or more quick connectors to be cleaned into the cleaning tank of an ultrasonic cleaning machine, and add cleaning liquid and reverse osmosis water into the cleaning tank for dilution, so that the concentration of citric acid is 2%; start the heating module and ultrasonic generating module of the ultrasonic cleaning machine, heat the liquid in the cleaning tank to 85°C, and perform ultrasonic cleaning on the quick connector for 5 minutes, and discharge the waste liquid in the cleaning tank after cleaning; S3. Preliminary flushing: inject reverse osmosis water into the cleaning tank to flush the quick connector, and discharge the waste liquid in the cleaning tank after cleaning; S4. Secondary cleaning: add sodium hypochlorite disinfectant and reverse osmosis water to the cleaning tank for dilution, so that the concentration of sodium hypochlorite is 0.05%, start the ultrasonic generator module at room temperature, and perform ultrasonic cleaning on the quick connector for 5 minutes for disinfection. After disinfection, discharge the waste liquid in the cleaning tank; S5. Secondary flushing: inject reverse osmosis water into the cleaning tank to flush the quick connector, and discharge the waste liquid in the cleaning tank after cleaning; S6. Take the quick connector out of the cleaning tank, dry it, and then reinstall it for use.

[0016] Embodiment 2 A method for cleaning a dialyzer quick connector comprises the following steps: S1. Configure the cleaning solution, the cleaning solution is composed of the following components by weight: 30 parts of citric acid, 4 parts of fruit acid, 4 parts of urotropine, 1 part of fatty alcohol polyoxyethylene ether, and the balance is deionized water; S2. Preliminary cleaning: place one or more quick connectors to be cleaned into the cleaning tank of an ultrasonic cleaning machine, and add cleaning liquid and reverse osmosis water into the cleaning tank for dilution, so that the concentration of citric acid is 3%; start the heating module and ultrasonic generating module of the ultrasonic cleaning machine, heat the liquid in the cleaning tank to 90°C, and perform ultrasonic cleaning on the quick connector for 10 minutes, and discharge the waste liquid in the cleaning tank after cleaning; S3. Preliminary flushing: inject reverse osmosis water into the cleaning tank to flush the quick connector, and discharge the waste liquid in the cleaning tank after cleaning; S4. Secondary cleaning: add sodium hypochlorite disinfectant and reverse osmosis water to the cleaning tank for dilution, so that the concentration of sodium hypochlorite is 0.1%, start the ultrasonic generator module at room temperature, and perform ultrasonic cleaning on the quick connector for 10 minutes for disinfection. After disinfection, discharge the waste liquid in the cleaning tank; S5. Secondary flushing: inject reverse osmosis water into the cleaning tank to flush the quick connector, and discharge the waste liquid in the cleaning tank after cleaning; S6. Take the quick connector out of the cleaning tank, dry it, and then reinstall it for use.

[0017] Embodiment 3 A method for cleaning a dialyzer quick connector comprises the following steps: S1. Configure the cleaning solution, the cleaning solution is composed of the following components by weight: 50 parts of citric acid, 5 parts of fruit acid, 5 parts of urotropine, 2 parts of fatty alcohol polyoxyethylene ether, and the balance is deionized water; S2. Preliminary cleaning: place one or more quick connectors to be cleaned into the cleaning tank of the ultrasonic cleaning machine, and add cleaning liquid and reverse osmosis water to dilute the cleaning tank so that the concentration of citric acid is 5%; start the heating module and ultrasonic generating module of the ultrasonic cleaning machine, heat the liquid in the cleaning tank to 95°C, and perform ultrasonic cleaning on the quick connector for 15 minutes, and discharge the waste liquid in the cleaning tank after cleaning; S3. Preliminary flushing: inject reverse osmosis water into the cleaning tank to flush the quick connector, and discharge the waste liquid in the cleaning tank after cleaning; S4. Secondary cleaning: add sodium hypochlorite disinfectant and reverse osmosis water to the cleaning tank for dilution, so that the concentration of sodium hypochlorite is 0.2%, start the ultrasonic generator module at room temperature, and perform ultrasonic cleaning on the quick connector for 15 minutes for disinfection. After disinfection, discharge the waste liquid in the cleaning tank; S5. Secondary flushing: inject reverse osmosis water into the cleaning tank to flush the quick connector, and discharge the waste liquid in the cleaning tank after cleaning; S6. Take the quick connector out of the cleaning tank, dry it, and then reinstall it for use.

[0018] The general steps of the above three embodiments can be found in the attached Figure 1 , and in the three embodiments, when the concentration of citric acid is diluted to 2-5%, the concentration of fruit acid is diluted to 0.3-0.5% in proportion, the concentration of urotropine is diluted to 0.36-0.5% in proportion, and the concentration of fatty alcohol polyoxyethylene ether is diluted to 0.075-0.2% in proportion; on the other hand, the ultrasonic cleaning machine belongs to the existing products, and the cleaning tank, ultrasonic generating module and heating module are not the built-in components of the ultrasonic cleaning machine, so the specific structure and working principle thereof are not elaborated in detail in the present invention.

[0019] In summary, during the initial cleaning process, the cavitation effect of ultrasound is first used to accelerate the stripping and dissolution of dirt on the surface of the quick connector, and then the anticoagulant properties of citric acid at high temperature are used to combine citric acid with calcium ions and magnesium ions in blood stains to form a soluble complex to further remove calcium and magnesium crystal salts and dirt on the quick connector. At the same time, citric acid also has a certain disinfection and bactericidal effect when heated to 90°C, so the quick connector can be disinfected while cleaning it; the combination of fruit acid and citric acid can more accurately adjust the pH value of the system to meet specific requirements, while increasing the acidification effect to more effectively remove rust on the quick connector (metal material); hexamine can form a protective film on the surface of metals and other materials, thereby slowing down or preventing corrosion and avoiding damage to the quick connector during the cleaning process; fatty alcohol polyoxyethylene ether has emulsification, foaming, decontamination and dispersion properties, which can further assist in removing stains.‌ During the secondary cleaning process, the cavitation effect of ultrasound is first used to further peel off and dissolve the dirt remaining on the surface of the quick connector, and then the quick connector is disinfected for the second time by using the property of sodium hypochlorite to remove blood contamination at room temperature, which can more effectively kill various microorganisms and improve the safety of the quick connector.

[0020] It should be noted that the four components of the cleaning solution, citric acid, fruit acid, urotropine, and fatty alcohol polyoxyethylene ether, are relatively chemically stable after mixing, and can effectively improve the decontamination effect while having a disinfection effect; the citric acid and fruit acid in the cleaning solution will react chemically with sodium hypochlorite to produce toxic gases, so before the second cleaning, it is necessary to ensure that the cleaning solution in the cleaning tank is completely discharged, and to ensure that the cleaning solution on the quick connector is rinsed clean.

[0021] Comparative Example Soak and rinse one or more quick connectors with alcohol; or place one or more quick connectors in the cleaning tank of an ultrasonic cleaning machine, add conventional liquid to the cleaning tank and perform repeated ultrasonic cleaning.

[0022] Check and compare To check for dirt and damage, the surface of the dialyzer quick connector can be directly observed with the naked eye, and attention should be paid to checking whether there are obvious stains, particles or other foreign matter attached to the quick connector, and the degree of damage of the quick connector should be observed; if the naked eye observation is not clear enough, a more detailed inspection can be performed with the aid of a magnifying glass with a light source or other tools; after inspection, by comparing the size of dirt and the degree of damage on the quick connectors after cleaning in the above three embodiments and the comparative example, it can be seen that the quick connectors in the above three embodiments have less dirt and less damage after cleaning.

[0023] Check the microorganisms, use membrane filtration technology, microbial rapid test piece technology and other microbial detection methods to detect the samples obtained from the quick connector. After the detection, the residual amount of microorganisms on the quick connector after cleaning in the above three embodiments and the comparative example is compared. It can be seen that the quick connectors in the above three embodiments have less biological residues after cleaning.

[0024] For easier understanding, please refer to Table 1 for specific inspection results.

[0025] Citric acid and sodium hypochlorite will slightly corrode metals, but under the limitation of the reaction concentration and the protection of the protective film formed by urotropine, the amount of corrosion is negligible; alcohol has no corrosive effect on metals, but the descaling effect is poor, resulting in the inability to clean microorganisms covered by calcium crystals, thereby reducing the overall sterilization effect; normally, by observing the surface dirt and damage of the quick connector with the naked eye, a small amount of dirt and slight corrosion can meet the requirements of routine use; and the residual microbial content of the quick connector is below 10CFU / ㎝², which is normal and meets the requirements of use.

[0026] Furthermore, in step S2 to step S5, the frequency of the ultrasonic generating module is 40-60kHz, and the power density is 0.5-1.5W / cm²; under this condition, the quick connector can be cleaned more thoroughly.

[0027] Furthermore, in step S2, the ultrasonic cleaning machine also includes a first delivery pump, a water tank for storing reverse osmosis water, and a first liquid storage bottle for storing cleaning liquid. The ultrasonic cleaning machine starts the first delivery pump according to a preset program of its own control system, so that the first delivery pump pumps an appropriate amount of reverse osmosis water and cleaning liquid into the cleaning tank for automatic dilution, ensuring that the proportion of citric acid in the diluted liquid is 2-5%; this design allows the cleaning liquid to be automatically diluted, effectively improving the dilution accuracy of the cleaning liquid.

[0028] Furthermore, in step S4, the ultrasonic cleaning machine also includes a second delivery pump and a second liquid storage bottle for storing sodium hypochlorite disinfectant. The ultrasonic cleaning machine starts the second delivery pump according to a preset program of its own control system, so that the second delivery pump pumps an appropriate amount of reverse osmosis water and sodium hypochlorite disinfectant into the cleaning tank for automatic dilution, ensuring that the proportion of sodium hypochlorite in the diluted liquid is 0.05-0.2%; this design enables the sodium hypochlorite disinfectant to be automatically diluted, effectively improving the dilution accuracy of the sodium hypochlorite disinfectant.

[0029] Furthermore, in step S3 and step S5, when flushing the quick connector, the ultrasonic generating module can be turned on to perform ultrasonic cleaning on the quick connector for 5-10 minutes to remove residual cleaning liquid / sodium hypochlorite disinfectant and dirt particles on the quick connector, thereby improving the cleaning efficiency and cleanliness of the quick connector.

[0030] Furthermore, in steps S2 to S5, when discharging the waste liquid in the cleaning tank, the ultrasonic generating module can be turned on to perform ultrasonic cleaning on the quick connector for 5-10 minutes to ensure that the residual dirt and liquid in the cleaning tank are completely discharged, so as to avoid residual waste liquid in the cleaning tank affecting the subsequent liquid reaction.

[0031] Furthermore, in step S6, after the quick connector is taken out, it can be naturally drained in a sterile environment or quickly dried in a dryer to avoid contamination of the cleaned quick connector and facilitate installation and use of the quick connector.

[0032] It should also be noted that, although the embodiments of the present application have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and variations may be made to these embodiments without departing from the principles and spirit of the present application.

Claims

1. A method for cleaning a dialyzer quick connector, characterized in that: The following steps are involved: S1. Configure the cleaning solution, the cleaning solution is composed of the following components in parts by weight: 20-50 parts of citric acid, 3-5 parts of fruit acid, 3.6-5 parts of urotropine, 0.75-2 parts of fatty alcohol polyoxyethylene ether, and the balance is deionized water; S2. Preliminary cleaning: placing the quick connector to be cleaned into the cleaning tank of an ultrasonic cleaning machine, and adding cleaning liquid and reverse osmosis water to the cleaning tank for dilution, so that the concentration of citric acid is 2-5%; starting the heating module and ultrasonic generating module of the ultrasonic cleaning machine, heating the liquid in the cleaning tank to 85-95° C., and performing ultrasonic cleaning on the quick connector for 5-15 minutes, and discharging the waste liquid in the cleaning tank after cleaning; S3. Initial flushing: inject reverse osmosis water into the cleaning tank to flush the quick connector, and discharge the waste liquid in the cleaning tank after cleaning; S4. Secondary cleaning, adding sodium hypochlorite disinfectant and reverse osmosis water to the cleaning tank for dilution, so that the concentration of sodium hypochlorite is 0.05-0.2%, starting the ultrasonic generator module at room temperature, and performing ultrasonic cleaning for 5-15 minutes on the quick connector for disinfection, and discharging the waste liquid in the cleaning tank after disinfection; S5. Secondary flushing: inject reverse osmosis water into the cleaning tank to flush the quick connector, and discharge the waste liquid in the cleaning tank after cleaning; S6. Take out the quick connector from the cleaning tank, dry it, and then reinstall it for use.

2. A dialyzer quick connector cleaning method according to claim 1, characterized in that: In step S2 to step S5, the frequency of the ultrasonic generating module is 40-60kHz, and the power density is 0.5-1.5W / cm².

3. A dialyzer quick connector cleaning method according to claim 1, characterized in that: In step S2, the ultrasonic cleaning machine also includes a first delivery pump, a water tank for storing reverse osmosis water, and a first liquid storage bottle for storing cleaning liquid. The ultrasonic cleaning machine starts the first delivery pump according to a preset program of its own control system, so that the first delivery pump pumps an appropriate amount of reverse osmosis water and cleaning liquid into the cleaning tank for automatic dilution, ensuring that the proportion of citric acid in the diluted liquid is 2-5%.

4. A dialyzer quick connector cleaning method according to claim 3, characterized in that: In step S4, the ultrasonic cleaning machine also includes a second delivery pump and a second liquid storage bottle for storing sodium hypochlorite disinfectant. The ultrasonic cleaning machine starts the second delivery pump according to a preset program of its own control system, so that the second delivery pump pumps an appropriate amount of reverse osmosis water and sodium hypochlorite disinfectant into the cleaning tank for automatic dilution, ensuring that the proportion of sodium hypochlorite in the diluted liquid is 0.05-0.2%.

5. A dialyzer quick connector cleaning method according to claim 1, characterized in that: In step S3 and step S5, when flushing the quick connector, the ultrasonic generating module can be turned on to perform ultrasonic cleaning on the quick connector for 5-10 minutes to remove the cleaning solution / sodium hypochlorite disinfectant and dirt particles remaining on the quick connector.

6. A dialyzer quick connector cleaning method according to claim 1, characterized in that: In step S2 to step S5, when discharging the waste liquid in the cleaning tank, the ultrasonic generating module can be turned on to perform ultrasonic cleaning on the quick connector for 5-10 minutes to ensure that the residual dirt and liquid in the cleaning tank are completely discharged.

7. A dialyzer quick connector cleaning method according to claim 1, characterized in that: In step S6, after the quick connector is taken out, it can be naturally drained in a sterile environment or quickly dried in a dryer.

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