Traditional Chinese medicine composition for cattle and sheep mastitis, traditional Chinese veterinary medicine patch prepared from traditional Chinese medicine composition and preparation method of traditional Chinese veterinary medicine patch

Abstract

The invention relates to the technical field of traditional Chinese veterinary medicine research and development. The invention provides a traditional Chinese medicine composition for cattle and sheep mastitis, a traditional Chinese veterinary medicine patch prepared from the traditional Chinese medicine composition and a preparation method. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10-20 parts of rhizoma arisaematis, 25-35 parts of mint, 25-35 parts of rock candy, 10-15 parts of pinellia ternate, 10-15 parts of radix angelicae, 10-15 parts of asarum, 10-15 parts of teasel root, 10-15 parts of frankincense, 10-15 parts of myrrh, 5-10 parts of earthworm, 5-10 parts of rhizoma sparganii, 5-10 parts of curcuma zedoary, 5-10 parts of rhizoma typhonii, 5-10 parts of tribulus terrestris and 5-10 parts of radix aconiti agrestis. The traditional Chinese medicine composition disclosed by the invention has the effects of dispelling wind and drying dampness, eliminating carbuncle and expelling pus, promoting qi circulation and removing stasis, breaking blood and removing stasis, promoting blood circulation and dredging collaterals, penetrating the skin and relieving exterior syndrome, and eliminating scrofula and gall. The traditional Chinese medicine is clinically applied to the breast of an affected animal, so that the pathological symptoms such as swelling, heat pain, induration, exudation and abscess can be relieved, and the breast function of the female animal is gradually recovered.

Description

Technical Field

[0001] The invention relates to the technical field of research and development of traditional Chinese veterinary medicines, and in particular to a traditional Chinese medicine composition for mastitis of cattle and sheep, a traditional Chinese veterinary medicine patch prepared therefrom and a preparation method thereof. Background Art

[0002] As a traditional Chinese medicine, Chinese veterinary medicine has a history of development and application for thousands of years. Before modern times, Chinese veterinary medicine played a leading role in the prevention and treatment of livestock and poultry diseases, especially in the prevention and treatment of diseases of large livestock. It has rich experience, ensuring and promoting the long-term healthy development of the livestock and poultry farming industry.

[0003] In the long-term development and practice of Chinese veterinary medicine, a large amount of surgical diagnosis and treatment experience has been formed, especially for common surgical diseases such as sores, carbuncles, swellings, and poisons, and a systematic diagnosis and treatment theory has been formed. For example, the "Golden Mirror of Medical Ancestral" dialectically treats various surgical diseases. However, there is currently a lack of Chinese veterinary medicine preparations for surgery, which seriously hinders the prevention and treatment of common surgical diseases in livestock and poultry. Explore the development of Chinese veterinary medicine preparations for livestock and poultry surgery, give full play to the prevention and treatment of mastitis in cattle and sheep, and promote the healthy development of animal husbandry. Summary of the invention

[0004] The purpose of the present invention is to provide a Chinese medicine composition for mastitis in cattle and sheep, a Chinese veterinary medicine patch prepared therefrom and a preparation method thereof, which can alleviate pathological symptoms such as redness, swelling, heat and pain, nodules, exudation, abscesses, etc. by clinically applying the patch to the udder of the affected animal, and gradually restore the udder function of the female animal.

[0005] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0006] The invention provides a traditional Chinese medicine composition for treating mastitis in cattle and sheep. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10-20 parts of arisaema, 25-35 parts of mint, 25-35 parts of crystal sugar, 10-15 parts of pinellia tuber, 10-15 parts of angelica dahurica, 10-15 parts of asarum, 10-15 parts of dipsaccharum officinale, 10-15 parts of frankincense, 10-15 parts of myrrh, 5-10 parts of earthworm, 5-10 parts of trillium, 5-10 parts of zedoaria, 5-10 parts of white aconite, 5-10 parts of tribulus terrestris and 5-10 parts of aconite.

[0007] The invention also provides application of the traditional Chinese medicine composition in preparing products for treating mastitis in cattle and sheep.

[0008] Preferably, the product is a Chinese veterinary medicine patch.

[0009] The invention also provides a Chinese veterinary medicine patch prepared from the Chinese medicine composition.

[0010] The present invention also provides a method for preparing the Chinese veterinary medicine patch, comprising the following steps:

[0011] (1) Weighing Chinese medicinal raw materials according to proportions, and dividing the raw materials into Group A and Group B, wherein Group A includes Arisaema, mint, crystal sugar, Pinellia, Angelica dahurica, Asarum, Rhizoma Cynoglossi, Tribulus terrestris, and Aconitum kusnezoffii, and Group B includes Dipsacus asper, frankincense, myrrh, earthworm, Trillium, Curcuma zedoaria, mint, and crystal sugar;

[0012] (2) drying and crushing the Chinese medicinal raw materials of group A and group B respectively, and sieving to obtain Chinese medicinal powder A and Chinese medicinal powder B;

[0013] (3) soaking the Chinese medicine powder A and the Chinese medicine powder B in water, and then soaking them in ethanol to obtain Chinese medicine paste A and Chinese medicine paste B;

[0014] (4) adding water to Chinese medicine paste A and Chinese medicine paste B respectively, grinding them, and filtering to obtain Chinese medicine liquid A1, filter residue A, and Chinese medicine liquid B1, filter residue B;

[0015] (5) adding water to the filter residue A and the filter residue B respectively, grinding them, and filtering to obtain Chinese medicine liquid A2 and Chinese medicine liquid B2;

[0016] (6) combining the Chinese medicine liquid A1 and the Chinese medicine liquid A2, concentrating them, and adding crystal sugar to obtain Chinese medicine ointment A;

[0017] (7) combining the Chinese medicine liquid B1 and the Chinese medicine liquid B2, concentrating them, and adding crystal sugar to obtain Chinese medicine ointment B;

[0018] (8) soaking gauze with Chinese medicine ointment A and Chinese medicine ointment B respectively to obtain Chinese medicine strip A and Chinese medicine strip B;

[0019] (9) Arrange the Chinese medicine strip A and the Chinese medicine strip B at intervals to obtain the Chinese veterinary medicine patch.

[0020] Preferably, the mass ratio of rock sugar in group A to group B is 1:0.8-1.2, and the mass ratio of mint in group A to group B is 1:0.8-1.2.

[0021] Preferably, the moisture content of the Chinese medicinal raw material after drying in step (2) is 5-10%, and a 40-80 mesh sieve is used for sieving.

[0022] Preferably, the amount of water in step (3) is 40-60% of the mass of the Chinese medicine powder, the time for water infiltration is 7-9 hours, the amount of ethanol is 25-35% of the mass of the Chinese medicine powder, the time for ethanol infiltration is 4-6 hours, the concentration of ethanol is 35-41%, and the temperatures for water infiltration and ethanol infiltration are independently 35-39°C.

[0023] Preferably, the amount of water in step (4) and step (5) is independently 2.5 to 3.5 times the mass of the Chinese medicine powder, the grinding time is 8 to 12 minutes, and the concentration temperature in step (6) and step (7) is 45 to 55°C.

[0024] Preferably, the soaking time in step (8) is 8 to 12 minutes.

[0025] The invention provides a Chinese medicine composition for mastitis of cattle and sheep, a Chinese veterinary medicine patch prepared therefrom and a preparation method thereof. The Chinese medicine composition comprises the following raw materials in parts by weight: 10-20 parts of arisaema, 25-35 parts of mint, 25-35 parts of crystal sugar, 10-15 parts of pinellia, 10-15 parts of angelica dahurica, 10-15 parts of asarum, 10-15 parts of dipsaci, 10-15 parts of frankincense, 10-15 parts of myrrh, 5-10 parts of earthworms, 5-10 parts of trillium, 5-10 parts of zedoaria, 5-10 parts of white aconite, 5-10 parts of tribulus terrestris and 5-10 parts of aconite. The present invention combines Chinese veterinary drugs (rhizoma aconiti pulcherrimae, rhizoma arisae, rhizoma pinelliae) that can dispel wind and dampness, dry dampness and resolve stagnation, extinguish wind and reduce swelling, and Chinese veterinary drugs (radix angelicae dahuricae, rhizoma asarum, rhizoma tribulae, and mint) that can dispel wind and resolve exterior symptoms, and relieve inflammation and relieve pain, with Chinese veterinary drugs (frankincense, myrrh, zedoaria, rhizoma trilobae, rhizoma peltatidis, and rhizoma dioscoreae) that can activate blood circulation and remove blood stasis, and promote blood circulation and qi circulation, and prepare multifunctional medicated plasters according to the functional partitioning cycle, and synergistically treat symptoms such as swelling and pain of mastitis, induration that is difficult to eliminate, and dampness and toxicity coagulation. The present invention combines Chinese veterinary drugs (radix angelicae dahuricae, rhizoma asarum, rhizoma tribulae, rhizoma dioscoreae, rhizoma peltatidis, and rhizoma curcumae) that have anti-inflammatory effects according to modern pharmacological research, and utilizes components such as angelica coumarin, volatile oil of rhizoma asarum, total saponin of rhizoma tribulae, extract of rhizoma dioscoreae wine, earthworm peptide, and zedoaria oil to achieve antibacterial and anti-inflammatory effects. The present invention adds crystal sugar with a sticky effect to achieve the effects of harmonizing the properties of the medicine, adhering to the affected part and slow-release of the medicine, and prolonging the contact and action time between the medicine and the affected part. The present invention adds mint with a transdermal effect, utilizes the transdermal promoting effect of mint oil and menthol, and promotes the penetration and absorption of the active ingredients of the medicine, the development of the efficacy, and the excretion of poisons.

[0026] The Chinese veterinary medicine patch prepared by the invention is formulated according to the compatibility principle of monarch, minister, assistant and messenger. For patients with severe nodules, arisaema, pinellia, rhizoma aconitifolii and tricholoma terrestris are monarch medicines, frankincense, myrrh, spargillium and zedoaria are minister medicines, radix scutellariae, asarum, angelica dahurica, mint and earthworm are adjuvant medicines, and crystal sugar is a messenger medicine. All the medicines are used together to play the effects of dispelling wind and dispersing nodules, breaking blood and removing blood stasis, and drying dampness and detoxifying. For patients with severe swelling, frankincense, myrrh, spargillium and zedoaria are monarch medicines, arisaema, pinellia, rhizoma aconitifolii and tricholoma terrestris are minister medicines, radix scutellariae, asarum, angelica dahurica, mint and earthworm are adjuvant medicines, and crystal sugar is a messenger medicine. All the medicines are used together to play the effects of promoting blood circulation and unblocking meridians, dispelling wind and reducing swelling, and detoxifying and eliminating carbuncle.

[0027] Beneficial effects:

[0028] 1. The present invention combines the Chinese veterinary medicines such as Rhizoma Alba, Rhizoma Arisaematis, Rhizoma Pinelliae, etc. which can dispel wind and dampness, dry dampness and disperse nodules, extinguish wind and reduce swelling, and the Chinese veterinary medicines such as Radix Angelicae Dahuricae, Rhizoma Asarum, Rhizoma Tribulae, and Mentha which can relieve exterior symptoms and dispel wind, and relieve inflammation and relieve pain, with the Chinese veterinary medicines such as Olibanum, Myrrh, Rhizoma Curcumae, Rhizoma Trigonellae, Rhizoma Dipsaci, and Pheretima which can promote blood circulation and remove blood stasis, and promote the circulation of qi, and synergizes them according to the functional divisions to treat symptoms such as swelling and pain of mastitis, difficult-to-dissipate nodules, and condensation of qi and blood dampness and toxins.

[0029] 2. The present invention designs a continuous medicine immersion box, places medicines with different functions in different areas, and prepares a multifunctional circulating veterinary medicine patch to synergistically treat and prevent the functional disorder of mastitis.

[0030] 3. The veterinary patch of the present invention adjusts the dosage of drugs in different efficacy areas according to the different degrees of hyperplasia, nodules, swelling and coagulation of mastitis symptoms, so as to achieve the effects of prominent treatment and coordinated prevention.

[0031] 4. The present invention combines the Chinese veterinary medicines Angelica dahurica, Asarum, Tribulus terrestris, Dipsacus asper, Pheretima, Curcuma zedoaria and the like which have anti-inflammatory effects according to modern pharmacological research, and utilizes the Angelica dahurica coumarin, Asarum volatile oil, Tribulus terrestris total saponin, Dipsacus asper wine extract, earthworm peptide, Curcuma zedoaria oil and the like contained therein to have antibacterial and anti-inflammatory effects and restore breast function.

[0032] 5. The present invention adds peppermint which has the effect of dispelling exterior pathogens and penetrating skin, and utilizes the effect of peppermint oil and menthol to promote the penetration and absorption of the active ingredients of the medicine, the effect of the medicine, and the excretion of poisons.

[0033] 6. The present invention adds crystal sugar with a thickening effect to achieve the effects of harmonizing the medicinal properties, adhering to the affected part and slow-release of the medicinal effect, thereby prolonging the contact time between the drug and the affected part.

[0034] 7. The present invention uses a water permeator on the medicine patch to increase the wettability of the medicine patch, promote the release of effective drug components, facilitate drug absorption, and prevent skin dryness and damage. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] Figure 1 It is a structural diagram of the U-shaped plastic water seepage pipe and water seepage holes in the Chinese veterinary medicine patch of the present invention, wherein the water seepage holes are distributed in the upper, middle and lower parts of the U-shaped plastic water seepage pipe;

[0036] Figure 2 This is the overall structure diagram of the Chinese veterinary medicine patch of the present invention;

[0037] Figure 3 The present invention is a structural diagram of a punched nail plate used in the preparation process of the Chinese veterinary medicine patch. DETAILED DESCRIPTION

[0038] The invention provides a traditional Chinese medicine composition for treating mastitis in cattle and sheep. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10-20 parts of arisaema, 25-35 parts of mint, 25-35 parts of crystal sugar, 10-15 parts of pinellia tuber, 10-15 parts of angelica dahurica, 10-15 parts of asarum, 10-15 parts of dipsaccharum officinale, 10-15 parts of frankincense, 10-15 parts of myrrh, 5-10 parts of earthworm, 5-10 parts of trillium, 5-10 parts of zedoaria, 5-10 parts of white aconite, 5-10 parts of tribulus terrestris and 5-10 parts of aconite.

[0039] In the present invention, the amount of Arisaema consanguineum is preferably 12 to 18 parts, and more preferably 15 parts.

[0040] In the present invention, the amount of mint is preferably 28 to 32 parts, more preferably 30 parts.

[0041] In the present invention, the amount of crystal sugar is preferably 28 to 32 parts, more preferably 30 parts.

[0042] In the present invention, the number of portions of the pinellia tuber is preferably 11 to 14 portions, and more preferably 12 to 13 portions.

[0043] In the present invention, the amount of Angelica dahurica is preferably 11 to 14 parts, and more preferably 12 to 13 parts.

[0044] In the present invention, the amount of Asarum is preferably 11 to 14 parts, and more preferably 12 to 13 parts.

[0045] In the present invention, the amount of the dipsaccharide is preferably 11 to 14 parts, and more preferably 12 to 13 parts.

[0046] In the present invention, the amount of frankincense is preferably 11 to 14 parts, more preferably 12 to 13 parts.

[0047] In the present invention, the amount of myrrh is preferably 11 to 14 parts, and more preferably 12 to 13 parts.

[0048] In the present invention, the amount of earthworm is preferably 6 to 9 parts, more preferably 7 to 8 parts.

[0049] In the present invention, the number of the three-edged sword is preferably 6 to 9 parts, and more preferably 7 to 8 parts.

[0050] In the present invention, the amount of the Curcuma zedoaria is preferably 6 to 9 parts, and more preferably 7 to 8 parts.

[0051] In the present invention, the amount of the white aconite root is preferably 6 to 9 parts, and more preferably 7 to 8 parts.

[0052] In the present invention, the amount of the Tribulus terrestris is preferably 6 to 9 parts, more preferably 7 to 8 parts.

[0053] In the present invention, the amount of Aconitum kusnezoffii is preferably 6 to 9 parts, and more preferably 7 to 8 parts.

[0054] The invention also provides application of the traditional Chinese medicine composition in preparing products for treating mastitis in cattle and sheep.

[0055] In the present invention, the type of the product is preferably a Chinese veterinary medicine patch.

[0056] The invention also provides a Chinese veterinary medicine patch prepared from the Chinese medicine composition.

[0057] The present invention also provides a method for preparing the Chinese veterinary medicine patch, comprising the following steps:

[0058] (1) The raw materials are divided into group A and group B, wherein group A includes rhizoma arisaematis, mint, crystal sugar, pinellia tuber, angelica dahurica, asarum, rhizoma leucodermi, tribulus terrestris, and aconite, and group B includes rhizoma schizonepetae, frankincense, myrrh, earthworm, ternate gracile, zedoaria, mint, and crystal sugar;

[0059] (2) drying and crushing the Chinese medicinal raw materials of group A and group B respectively, and sieving to obtain Chinese medicinal powder A and Chinese medicinal powder B;

[0060] (3) soaking the Chinese medicine powder A and the Chinese medicine powder B in water, and then soaking them in ethanol to obtain Chinese medicine paste A and Chinese medicine paste B;

[0061] (4) adding water to Chinese medicine paste A and Chinese medicine paste B respectively, grinding them, and filtering to obtain Chinese medicine liquid A1, filter residue A, and Chinese medicine liquid B1, filter residue B;

[0062] (5) adding water to the filter residue A and the filter residue B respectively, grinding them, and filtering to obtain Chinese medicine liquid A2 and Chinese medicine liquid B2;

[0063] (6) combining the Chinese medicine liquid A1 and the Chinese medicine liquid A2, concentrating them, and adding crystal sugar to obtain Chinese medicine ointment A;

[0064] (7) combining the Chinese medicine liquid B1 and the Chinese medicine liquid B2, concentrating them, and adding crystal sugar to obtain Chinese medicine ointment B;

[0065] (8) soaking gauze with Chinese medicine ointment A and Chinese medicine ointment B respectively to obtain Chinese medicine strip A and Chinese medicine strip B;

[0066] (9) Arrange the Chinese medicine strip A and the Chinese medicine strip B at intervals to obtain the Chinese veterinary medicine patch.

[0067] In the present invention, the mass ratio of rock sugar in group A and group B is preferably 1:0.8-1.2, more preferably 1:1, and the mass ratio of mint in group A and group B is preferably 1:0.8-1.2, more preferably 1:1.

[0068] In the present invention, the moisture content of the dried Chinese medicinal material in step (2) is preferably 5-10%, more preferably 7-8%, and the sieving is preferably performed using a 40-80 mesh sieve, more preferably a 60 mesh sieve.

[0069] In the present invention, the amount of water in step (3) is preferably 40-60% of the mass of the Chinese medicine powder, and more preferably 50%. The time for water infiltration is preferably 7-9 hours, and more preferably 8 hours. The amount of ethanol is preferably 25-35% of the mass of the Chinese medicine powder, and more preferably 30%. The time for ethanol infiltration is preferably 4-6 hours, and more preferably 5 hours. The concentration of ethanol is preferably 35-41%, and more preferably 38%. The temperatures for water infiltration and ethanol infiltration are independently preferably 35-39°C, and more preferably 37°C.

[0070] In the present invention, the amount of water used in step (4) and step (5) is preferably 2.5 to 3.5 times the mass of the Chinese medicine powder, and more preferably 3 times the mass of the Chinese medicine powder. The grinding time is preferably 8 to 12 minutes, and more preferably 10 minutes.

[0071] In the present invention, the concentration temperature in step (6) and step (7) is preferably 45 to 55°C, more preferably 50°C.

[0072] In the present invention, the soaking time in step (8) is preferably 8 to 12 minutes, more preferably 10 minutes.

[0073] Arisaema: "Kaibao Materia Medica" says that it can break up hard masses and eliminate carbuncles and swellings; "Shengji Zonglu" says that Arisaema can disperse goiters and Arisaema paste can treat carbuncles, ulcers and boils. Modern research shows that it has analgesic and sedative effects.

[0074] Pinellia: "Compendium of Materia Medica" says that applying newly grown Pinellia can eliminate carbuncle and scrofula; "Secret of Main Treatments" says that it can eliminate swelling and disperse nodules. Modern research shows that it has immune-enhancing and anti-tumor effects.

[0075] White aconite root: "Chinese Materia Medica" says that it can be crushed with Arisaema consanguineum to treat phlegm nodules, and "Chinese Materia Medica Encyclopedia" says that it can be combined with Arisaema consanguineum, Aconitum kusnezoffii and Chuanwu to make Sihusan to treat carbuncle and swelling. Modern research shows that it has antibacterial and immune-enhancing effects.

[0076] Tribulus terrestris: "Clinical Guide" says that it can treat horizontal stuffiness and stagnant qi between the breasts, and "Fang Longtan Family Secret" says that it can be used together with pangolin and fenugreek to treat breast obstruction and breast rocks. Modern research shows that it has anti-inflammatory and anti-allergic effects.

[0077] Angelica dahurica: "Yi Zong Jin Jian" says that it is suitable for carbuncles and ulcers caused by accumulation of evil toxins and stagnation of vital energy. For example, the Li Xiao San in "Yang Yi Da Quan" says that it can be used with pangolin, astragalus, angelica, and raw rehmannia to treat all carbuncles and swellings. Modern pharmacological research shows that it has antibacterial, anti-inflammatory, and analgesic effects.

[0078] Asarum: It has the effects of dispelling wind and cold, relieving pain and opening the orifices. Its pungent fragrance can go through the orifices and is good at flowing through the milk veins. It can be used together with Citrus aurantium, Bupleurum, Prunella Vulgaris, Pangolin, Vaccaria segetalis, etc. to treat breast swelling and pain. "Bencao Zhengyi" says that it has the strongest fragrance and is good at dispersing nodules and relieving depression. Modern research shows that it has antipyretic, analgesic and anti-inflammatory effects.

[0079] Dipsacus asper: "Shennong's Herbal Classic" says it can cure breast problems, and "Bencao Huiyan" says it can be used with Taraxacum mongolicum to cure mastitis and breast pain. Modern studies have shown that the ethanol extract has anti-inflammatory effects.

[0080] Earthworm: It has the effects of relieving fever and calming the nerves, unblocking meridians and dispelling wind. Modern research shows that it has the effects of improving microcirculation, relieving inflammation and pain, anti-allergy, antibacterial, and promoting wound healing.

[0081] Frankincense: It has the effects of promoting blood circulation, relieving qi and relieving pain, reducing swelling and promoting tissue regeneration. For example, "Annotated Prescriptions for Women" says that it can be used with Angelica dahurica, pangolin and honeysuckle to treat carbuncles and furuncles. "Compendium of Materia Medica" says it is an important medicine for eliminating carbuncles and ulcers. Modern research has shown that it has analgesic and anti-inflammatory effects.

[0082] Myrrh: It has the effects of promoting blood circulation, relieving pain, reducing swelling and promoting tissue regeneration. For example, the Complete Book of Ulcers says that it can be used with frankincense, realgar and dragon's blood to treat furuncle and unidentified swelling. Modern pharmacological studies have shown that it has antibacterial effects. Curcuma has the effects of breaking blood and promoting qi. The Compendium of Materia Medica says that Curcuma's functions of promoting qi, breaking blood and dispersing nodules are its strengths. Modern studies have shown that Curcuma has antibacterial, anti-inflammatory and anti-proliferative effects.

[0083] Trillium: It can break up blood and promote the flow of qi. As stated in Youyou Xinshu, it can be used with rhubarb and earthworm to eliminate symptoms, expel evil spirits, soften and disperse lumps. Bencao Jingshu says it can treat all coagulation, stagnation and visible hard masses. Modern pharmacological research shows that it has analgesic and blood viscosity reducing effects.

[0084] Mint: It has the effect of dispersing wind-heat. "Compendium of Materia Medica" says it is an important medicine for treating scrofula and scabies. Modern research shows that it has antipyretic, anti-inflammatory, antiviral and skin-penetrating effects.

[0085] Rock sugar: It has the function of harmonizing medicinal properties, thickening ointments, and slow-release drug effects.

[0086] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0087] Example 1

[0088] (1) The Chinese veterinary medicine patch of this example is composed of the following Chinese veterinary medicine raw materials in parts by weight: 10 parts of arisaema, 30 parts of mint, 30 parts of crystal sugar, 10 parts of pinellia, 10 parts of angelica dahurica, 10 parts of asarum, 10 parts of dipsaccharum, 15 parts of frankincense, 15 parts of myrrh, 10 parts of earthworm, 10 parts of trillium, 10 parts of zedoaria, 5 parts of white aconite, 5 parts of tribulus terrestris, and 10 parts of aconite.

[0089] (2) The preparation method is:

[0090] S1 The veterinary medicine patch is composed of A and B functional areas in a circle. The medicinal materials in area A are composed of arisaema, mint, crystal sugar, pinellia, angelica dahurica, asarum, white aconite, tribulus terrestris, and aconite, etc.; the medicinal materials in area B are composed of dipsacus, frankincense, myrrh, earthworm, trillium, zedoaria, mint, and crystal sugar, etc.

[0091] S2 first weighs the Chinese veterinary medicine in the corresponding area according to mass, and then dries it in a drying oven at 60°C to make the moisture content less than 10%. The above-mentioned medicinal materials in areas A and B are crushed separately and passed through a 60-mesh sieve for later use.

[0092] S3 puts the drug powders in S2 into a special drug immersion box (the drug immersion box is 30 cm long, 5 cm wide, and 2 cm high, divided into 6 sections, each 5 cm long, separated by partitions, and respectively used as small circulating drug immersion boxes for area A and area B), first add water to soak for 8 hours (the mass ratio of drug to water is 1:0.5), and then add 38-degree white wine to soak for 5 hours (the mass ratio of drug to wine is 1:0.3). The drug infiltration of water and wine is carried out in a constant temperature box at 37°C.

[0093] S4: Put the soaked medicine in S3 into a pulper, add pure water to grind for 10 minutes (the mass ratio of medicine to water is 1:3), filter the medicine liquid, grind the medicine residue again for 10 minutes (the mass ratio of medicine to water is 1:3), filter the medicine liquid, collect the medicine liquid collected twice in a distillation bottle, heat at 50°C to evaporate the water, wait until the medicine liquid becomes a paste, add 15 parts of crystal sugar to dissolve and stir evenly, stop heating, and pour it into a medicine collection box for use.

[0094] S5 Cut the densely woven medical gauze into 40cm long and 5cm wide medicine sticky strips, leaving 5cm at each end of the medicine sticky strips, and then place them parallel to each other in the medicine soaking box and soak them for 10 minutes until the ointment is evenly adhered. Stick absorbent paper on the back of the ointment and cover the medicine surface with plastic wrap to seal and fix it.

[0095] S6: Place the Chinese veterinary medicine patch in S5 above flat on a wooden board, use a special punching needle plate to evenly punch holes in sequence, and then sew and install 4 U-shaped plastic water seepage pipes with a length of 10 cm and an inner diameter of 1.5 mm on the back of the patch every 7 cm, and pierce a pair of water seepage holes on the upper, middle and lower parts of the side of the water seepage pipe. When the production is completed, fold the patch into 6 sections, put it in a plastic bag, and store it in a refrigerator.

[0096] (3) The method of using the veterinary patch in this example includes the following steps:

[0097] S1 Before use, take the above-mentioned Chinese veterinary medicine patch out of the refrigerator, put it into a 55℃ water bath and heat it for 1 hour, take out the patch, fill the water seepage tube with physiological saline, then remove the plastic wrap and apply it to the affected area.

[0098] The application time of S2 Chinese veterinary patch is 24 hours, 4 patches are one course of treatment, 4 courses of treatment are one treatment cycle, and there is a 1-day interval between each course of treatment without taking the medicine.

[0099] Example 2

[0100] (1) The veterinary plaster in this example is composed of the following Chinese veterinary drugs in parts by weight: 20 parts of arisaema, 30 parts of mint, 30 parts of crystal sugar, 15 parts of pinellia, 15 parts of angelica dahurica, 15 parts of asarum, 15 parts of dipsaci, 10 parts of frankincense, 10 parts of myrrh, 5 parts of earthworm, 5 parts of trillium, 5 parts of zedoaria, 10 parts of white aconite, 10 parts of tribulus terrestris, and 5 parts of aconite.

[0101] (2) The preparation method is:

[0102] S1 The veterinary medicine patch is composed of A and B functional areas in a circle. The medicinal materials in area A are composed of arisaema, mint, crystal sugar, pinellia, angelica dahurica, asarum, white aconite, tribulus terrestris, and aconite, etc.; the medicinal materials in area B are composed of dipsacus, frankincense, myrrh, earthworm, trillium, zedoaria, mint, and crystal sugar, etc.

[0103] S2 first weighs the mass of the veterinary drugs in the corresponding area, and then dries it in a drying oven at 50°C to make the moisture content less than 10%. The above-mentioned medicinal materials in areas A and B are crushed separately and passed through a 60-mesh sieve for later use.

[0104] S3 puts the drug powders in S2 into a special drug immersion box (the drug immersion box is 30 cm long, 5 cm wide, and 2 cm high, divided into 6 sections, each 5 cm long, separated by partitions, and respectively used as small circulating drug immersion boxes for area A and area B), first add water to soak for 8 hours (the mass ratio of drug to water is 1:0.5), and then add 38-degree white wine to soak for 5 hours (the mass ratio of drug to wine is 1:0.3). The drug infiltration of water and wine is carried out in a constant temperature box at 37°C.

[0105] S4: Put the soaked medicine in S3 into a pulper, add pure water to grind for 10 minutes (the mass ratio of medicine to water is 1:3), filter the medicine liquid, grind the medicine residue again for 10 minutes (the mass ratio of medicine to water is 1:3), filter the medicine liquid, collect the medicine liquid collected twice in a distillation bottle, heat at 50°C to evaporate the water, wait until the medicine liquid becomes a paste, add 15 parts of crystal sugar to dissolve and stir evenly, stop heating, and pour it into a medicine collection box for use.

[0106] S5 Cut the densely woven medical gauze into 40cm long and 5cm wide medicine sticky strips, leaving 5cm at each end of the medicine sticky strips, and then place them parallel to each other in the medicine soaking box and soak them for 10 minutes until the ointment is evenly adhered. Stick absorbent paper on the back of the ointment and cover the medicine surface with plastic wrap to seal and fix it.

[0107] S6: Place the Chinese veterinary medicine patch in S5 above flat on a wooden board, use a special punching needle plate to evenly punch holes in sequence, and then sew and install 4 U-shaped plastic water seepage pipes with a length of 10 cm and an inner diameter of 1.5 mm on the back of the patch every 7 cm, and pierce a pair of water seepage holes on the upper, middle and lower parts of the side of the water seepage pipe. When the production is completed, fold the patch into 6 sections, put it in a plastic bag, and store it in a refrigerator.

[0108] (3) The method of using the veterinary patch in this example includes the following steps:

[0109] S1 Before use, take the above-mentioned Chinese veterinary medicine patch out of the refrigerator, put it into a 55°C water bath and heat it for 1 hour, take out the patch, inject normal saline into the seepage tube, then remove the plastic wrap and apply it to the affected area.

[0110] The application time of S2 Chinese veterinary patch is 24 hours, 4 patches are one course of treatment, 4 courses of treatment are one treatment cycle, and there is a 1-day interval between each course of treatment without taking the medicine.

[0111] Example 3

[0112] (1) The Chinese veterinary medicine patch of this embodiment is composed of the following Chinese veterinary medicines in parts by weight:

[0113] 15 parts of Arisaema, 30 parts of Menthus, 30 parts of Rock Sugar, 15 parts of Pinellia, 10 parts of Angelica dahurica, 10 parts of Asarum, 10 parts of Dipsacus asper, 15 parts of Olibanum, 15 parts of Myrrh, 10 parts of Pheretima, 10 parts of Sparganium, 10 parts of Curcuma, 10 parts of Rhizoma Alba, 10 parts of Tribulus Terrestris, 10 parts of Aconitum.

[0114] (2) The preparation method is:

[0115] S1 The veterinary medicine patch is composed of A and B functional areas in a circle. The medicinal materials in area A are composed of Arisaema, Pinellia, Angelica dahurica, Asarum, Rhizoma Aconitum, Tribulus Terrestris, Aconitum, Mint, and crystal sugar; the medicinal materials in area B are composed of frankincense, Myrrh, Trillium, Curcuma, Dipsacus asper, Pheretima, Mint, and crystal sugar.

[0116] S2 first weighs the mass of the veterinary drugs in the corresponding area, and then dries it in a drying oven at 55°C to make the moisture content less than 10%. The above-mentioned medicinal materials in areas A and B are crushed separately and passed through a 60-mesh sieve for later use.

[0117] S3 Place the drug powders in S2 above into a special drug immersion box (the drug immersion box is 30 cm long, 5 cm wide, and 2 cm high, divided into 6 sections, each 5 cm long, separated by partitions, which are the circulating drug immersion boxes in area A and area B respectively), first add water to soak for 8 hours (the mass ratio of drug to water is 1:0.5), and then add 38o white wine to soak for 5 hours (the mass ratio of drug to wine is 1:0.3). The drug infiltration of water and wine is carried out in a constant temperature box at 37°C.

[0118] S4: Put the soaked medicine in S3 into a pulper, add pure water to grind for 10 minutes (the mass ratio of medicine to water is 1:3), filter the medicine liquid, grind the medicine residue again for 10 minutes (the mass ratio of medicine to water is 1:3), filter the medicine liquid, collect the medicine liquid collected twice in a distillation bottle, heat at 50°C to evaporate the water, wait until the medicine liquid becomes a paste, add 15 parts of crystal sugar to dissolve and stir evenly, stop heating, and pour it into a medicine collection box for use.

[0119] S5 Cut the densely woven medical gauze into 40cm long and 5cm wide medicine sticky strips, leaving 5cm at each end of the medicine sticky strips, and then place them parallel to each other in the medicine soaking box and soak them for 10 minutes until the ointment is evenly adhered. Stick absorbent paper on the back of the ointment and cover the medicine surface with plastic wrap to seal and fix it.

[0120] S6: Place the Chinese veterinary medicine patch in S5 above flat on a wooden board, use a special punching needle plate to evenly punch holes in sequence, and then sew and install 4 U-shaped plastic water seepage pipes with a length of 10 cm and an inner diameter of 1.5 mm on the back of the patch every 7 cm, and pierce a pair of water seepage holes on the upper, middle and lower parts of the side of the water seepage pipe. When the production is completed, fold the patch into 6 sections, put it in a plastic bag, and store it in a refrigerator.

[0121] (3) The method of using the veterinary patch in this example includes the following steps:

[0122] S1 Before use, take the above-mentioned Chinese veterinary medicine patch out of the refrigerator, put it into a 55℃ water bath and heat it for 1 hour, take out the patch, fill the water seepage tube with physiological saline, then remove the plastic wrap and apply it to the affected area.

[0123] The application time of S2 Chinese veterinary patch is 24 hours, 4 patches are one course of treatment, 4 courses of treatment are one treatment cycle, and there is a 1-day interval between each course of treatment without taking the medicine.

[0124] Example 4

[0125] (1) The veterinary plaster in this example is composed of the following Chinese veterinary drugs in parts by weight: 20 parts of arisaema, 35 parts of mint, 35 parts of crystal sugar, 15 parts of pinellia, 15 parts of angelica dahurica, 15 parts of asarum, 15 parts of dipsaci, 15 parts of frankincense, 15 parts of myrrh, 10 parts of earthworm, 10 parts of trillium, 10 parts of curcuma, 10 parts of white aconite, 10 parts of tribulus terrestris, and 10 parts of aconite.

[0126] (2) The preparation method is:

[0127] S1 The veterinary medicine patch is composed of A and B functional areas in a circle. The medicinal materials in area A are composed of Arisaema, Pinellia, Angelica dahurica, Asarum, Rhizoma Aconitum, Tribulus Terrestris, Aconitum, Mint, and crystal sugar; the medicinal materials in area B are composed of frankincense, Myrrh, Trillium, Curcuma, Dipsacus asper, Pheretima, Mint, and crystal sugar.

[0128] S2 first weighs the mass of the veterinary drugs in the corresponding area, and then dries it in a drying oven at 55°C to make the moisture content less than 10%. The above-mentioned medicinal materials in areas A and B are crushed separately and passed through a 60-mesh sieve for later use.

[0129] S3 puts the drug powders in S2 into a special drug immersion box (the drug immersion box is 30 cm long, 5 cm wide, and 2 cm high, divided into 6 sections, each 5 cm long, separated by partitions, and respectively used as small circulating drug immersion boxes for area A and area B), first add water to soak for 8 hours (the mass ratio of drug to water is 1:0.5), and then add 38-degree white wine to soak for 5 hours (the mass ratio of drug to wine is 1:0.3). The drug infiltration of water and wine is carried out in a constant temperature box at 37°C.

[0130] S4: Put the soaked medicine in S3 into a pulper, add pure water to grind for 10 minutes (the mass ratio of medicine to water is 1:3), filter the medicine liquid, grind the medicine residue again for 10 minutes (the mass ratio of medicine to water is 1:3), filter the medicine liquid, collect the medicine liquid collected twice in a distillation bottle, heat at 50°C to evaporate the water, wait until the medicine liquid becomes a paste, add 15 parts of crystal sugar to dissolve and stir evenly, stop heating, and pour it into a medicine collection box for use.

[0131] S5 Cut the densely woven medical gauze into 40cm long and 5cm wide medicine sticky strips, leaving 5cm at each end of the medicine sticky strips, and then place them parallel to each other in the medicine soaking box and soak them for 10 minutes until the ointment is evenly adhered. Stick absorbent paper on the back of the ointment and cover the medicine surface with plastic wrap to seal and fix it.

[0132] S6: Place the Chinese veterinary medicine patch in S5 above flat on a wooden board, use a special punching needle plate to evenly punch holes in sequence, and then sew and install 4 U-shaped plastic water seepage pipes with a length of 10 cm and an inner diameter of 1.5 mm on the back of the patch every 7 cm, and pierce a pair of water seepage holes on the upper, middle and lower parts of the side of the water seepage pipe. When the production is completed, fold the patch into 6 sections, put it in a plastic bag, and store it in a refrigerator.

[0133] (3) The method of using the veterinary patch in this example includes the following steps:

[0134] S1 Before use, take the above-mentioned Chinese veterinary medicine patch out of the refrigerator, put it into a 55℃ water bath and heat it for 1 hour, take out the patch, fill the water seepage tube with physiological saline, then remove the plastic wrap and apply it to the affected area.

[0135] The application time of S2 Chinese veterinary patch is 24 hours, 4 patches are one course of treatment, 4 courses of treatment are one treatment cycle, and there is a 1-day interval between each course of treatment without taking the medicine.

[0136] Test example

[0137] From 2019 to 2021, a total of 55 cases of the above-mentioned type of mastitis were treated in large-scale sheep farms. After antibiotics and anti-inflammatory drugs were ineffective, the above-mentioned Chinese veterinary medicine patch was used for treatment, and good treatment effects were achieved. The specific results are shown in Table 1:

[0138] Table 1 Record of clinical application effect of veterinary patch

[0139]

[0140]

[0141] As can be seen from the above embodiments, the present invention provides a Chinese medicine composition for mastitis of cattle and sheep and a Chinese veterinary medicine patch prepared therefrom and a preparation method thereof, wherein the Chinese medicine composition comprises the following raw materials in parts by weight: 10-20 parts of arisaema, 25-35 parts of mint, 25-35 parts of crystal sugar, 10-15 parts of pinellia tuber, 10-15 parts of angelica dahurica, 10-15 parts of asarum, 10-15 parts of diaspermum, 10-15 parts of frankincense, 10-15 parts of myrrh, 5-10 parts of earthworm, 5-10 parts of trillium, 5-10 parts of curcuma, 5-10 parts of white aconite, 5-10 parts of tribulus terrestris, and 5-10 parts of aconite. The Chinese medicine composition of the present invention has the effects of dispelling wind and dampness, eliminating carbuncle and pus, promoting qi and dispersing knots, breaking blood and removing blood stasis, promoting blood circulation and unblocking collaterals, penetrating muscles and relieving exterior symptoms, eliminating scrofula and removing galls. By clinically applying the patch to the breasts of affected animals, pathological symptoms such as redness, swelling, heat, pain, nodules, exudation, and abscesses can be alleviated, and the breast function of the mother animal can be gradually restored.

[0142] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating mastitis in cattle and sheep, characterized in that: The invention comprises the following raw materials in parts by weight: 10-20 parts of arisaema, 25-35 parts of mint, 25-35 parts of crystal sugar, 10-15 parts of pinellia, 10-15 parts of angelica dahurica, 10-15 parts of asarum, 10-15 parts of dipsaccharum, 10-15 parts of frankincense, 10-15 parts of myrrh, 5-10 parts of earthworm, 5-10 parts of trillium, 5-10 parts of zedoaria, 5-10 parts of white aconite, 5-10 parts of tribulus terrestris and 5-10 parts of aconite.

2. Use of the Chinese medicine composition according to claim 1 in preparing products for treating mastitis in cattle and sheep.

3. The use according to claim 2, characterized in that: The type of product described is a Chinese veterinary medicine patch.

4. A Chinese veterinary medicine patch prepared from the Chinese medicine composition according to claim 1.

5. The method for preparing the Chinese veterinary medicine patch according to claim 4, characterized in that: The steps include: (1) Weighing Chinese medicinal raw materials according to proportions, and dividing the raw materials into Group A and Group B, wherein Group A includes Arisaema, mint, crystal sugar, Pinellia, Angelica dahurica, Asarum, Rhizoma Cynoglossi, Tribulus terrestris, and Aconitum kusnezoffii, and Group B includes Dipsacus asper, frankincense, myrrh, earthworm, Trillium, Curcuma zedoaria, mint, and crystal sugar; (2) drying and crushing the Chinese medicinal raw materials of group A and group B respectively, and sieving to obtain Chinese medicinal powder A and Chinese medicinal powder B; (3) soaking the Chinese medicine powder A and the Chinese medicine powder B in water, and then soaking them in ethanol to obtain Chinese medicine paste A and Chinese medicine paste B; (4) adding water to the Chinese medicine paste A and the Chinese medicine paste B respectively, grinding them, and filtering to obtain Chinese medicine liquid A1, filter residue A, and Chinese medicine liquid B1, filter residue B; (5) adding water to the filter residue A and the filter residue B respectively, grinding them, and filtering to obtain Chinese medicine liquid A2 and Chinese medicine liquid B2; (6) combining the Chinese medicine liquid A1 and the Chinese medicine liquid A2, concentrating them, and adding crystal sugar to obtain Chinese medicine ointment A; (7) combining the Chinese medicine liquid B1 and the Chinese medicine liquid B2, concentrating them, and adding crystal sugar to obtain Chinese medicine ointment B; (8) soaking gauze with Chinese medicine ointment A and Chinese medicine ointment B respectively to obtain Chinese medicine strip A and Chinese medicine strip B; (9) Arrange the Chinese medicine strip A and the Chinese medicine strip B at intervals to obtain the Chinese veterinary medicine patch.

6. The preparation method according to claim 5, characterized in that: The mass ratio of rock sugar in group A to group B is 1:0.8-1.2, and the mass ratio of mint in group A to group B is 1:0.8-1.

2.

7. The preparation method according to claim 6, characterized in that: The moisture content of the Chinese medicinal raw material after drying in step (2) is 5-10%, and a 40-80 mesh sieve is used for sieving.

8. The preparation method according to claim 7, characterized in that: The amount of water in step (3) is 40-60% of the weight of the Chinese medicine powder, the time for water soaking is 7-9 hours, the amount of ethanol is 25-35% of the weight of the Chinese medicine powder, the time for ethanol soaking is 4-6 hours, the concentration of ethanol is 35-41%, and the temperatures for water soaking and ethanol soaking are independently 35-39°C.

9. The preparation method according to claim 8, characterized in that: The amount of water used in step (4) and step (5) is independently 2.5 to 3.5 times the mass of the Chinese medicine powder, the grinding time is 8 to 12 minutes, and the concentration temperature in step (6) and step (7) is 45 to 55°C.

10. The preparation method according to any one of claims 5 to 9, characterized in that: The soaking time in step (8) is 8 to 12 minutes.

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