Automatic centrifugal machine capable of enabling centrifugal cup to be vertical

Abstract

The invention discloses an automatic centrifugal machine capable of achieving vertical arrangement of centrifugal cups. The centrifugal machine comprises a plurality of centrifugal cups which are arranged on a centrifugal rotating disc. The magnetic structure is a sheet type structure and is fixed at the bottom of each centrifugal cup; the centrifugal cup further comprises a magnetic attraction structure, the magnetic attraction structure is arranged in the centrifugal machine, the magnetic attraction force of the magnetic attraction structure attracts the magnetic structure to perform magnetic attraction action, meanwhile, the centrifugal cup is driven to rotate, and finally the movement stop state of the centrifugal cup is the vertical state of the centrifugal cup; the centrifugal rotating disc rotates to drive the centrifugal cups to pass through the magnetic attraction structures, magnetic attraction actions are generated, each centrifugal cup reaches a vertical state after the centrifugal rotating disc rotates by 360 degrees, and a magnet induction structure only capable of inducting the magnetic structures on the centrifugal cups in the vertical state is additionally arranged to monitor whether the centrifugal cups are in the vertical state or not; through cooperation of the magnetic structure, the magnetic attraction structure and the magnet induction structure, the centrifugal cup enters the next automatic exosome enrichment stage after being in a vertical state.

Description

Technical Field

[0001] The present invention belongs to the field of centrifuges, and in particular to the technical field of automatically placing various centrifuge tubes in a vertical state into a centrifuge for centrifugal treatment or taking them out of the centrifuge for use in automated exosome processing, and specifically is a centrifuge that automatically realizes the vertical position of a centrifuge cup. Background Art

[0002] The enrichment of blood-derived neurogenic exosomes is a cumbersome process that consumes a lot of manpower and is prone to operational errors due to improper operation. Therefore, automated exosome enrichment equipment is needed. 202110247374.3 An automated device for effectively enriching neurogenic exosomes in blood and 202210874984.0 An exosome enrichment system; 202410109881.4 A blood-derived neurogenic exosome enrichment device and other prior arts disclose automated enrichment equipment, which is actually a gradual iterative process. When it is implemented specifically, it not only faces overall problems but also faces specific problems of each structure.

[0003] Because the exosome automation instrument rotates to an open-cover operating state, and the centrifuge tube is placed in the centrifuge or taken out of the centrifuge in a vertical state during the process to ensure the feasibility of the automated operation process, but how to make the centrifuge tube in the centrifuge always maintain a vertical state is a key technical problem to be solved. 202410730340.3 A centrifuge, which discloses a method of maintaining a safe and effective centrifugal inclination during centrifugation by limiting the rotor (centrifuge cup) in a limit groove, and arranging a heavier part at the bottom of the rotor to achieve a method in which the center of the rotor is lower than the shaft, thereby ensuring that the shaft maintains a vertical state when stopped; but although this method of increasing the weight of the rotor bottom can achieve the vertical state after centrifugation, the weight of the rotor causes a lot of increase in the centrifugal force, which increases the workload of the centrifuge, and then causes the motor of the small centrifuge to be unable to meet the centrifugal force requirements, which will eventually cause the entire product to become larger. Therefore, a technical solution is needed to ensure that the centrifuge cup can maintain a vertical state under the premise of maintaining a smaller centrifuge motor to provide centrifugal force.

[0004] The invention provides a centrifuge which can automatically realize the vertical position of a centrifugal cup. Summary of the invention

[0005] In view of the existing technology 202410730340.3, a centrifuge has the problem that the small centrifuge motor cannot achieve effective centrifugal force when enriching blood-derived exosomes due to the increased weight of the centrifuge cup, resulting in poor enrichment effect. If a centrifuge with a larger motor is used, the space occupied by the entire exosome device will increase a lot, which is inconsistent with the current technical route of miniaturizing the exosome enrichment device as much as possible. Therefore, it is urgent to find a new technical solution that can maintain the centrifuge cup in a vertical state during the process of taking and placing the centrifuge tube in the centrifuge without increasing or increasing the weight of the centrifuge cup very little.

[0006] The present invention uses a lighter centrifuge cup. Except for the technical feature of maintaining a vertical state, the other methods of the centrifuge cup are basically the same as the technology of 202410730340.3 A centrifuge. Specifically, a thin-sheet magnetic structure is set at the bottom of each centrifuge cup. The bottom plane of the thin-sheet magnetic structure is perpendicular to the longitudinal axis of the centrifuge cup. A magnetic attraction structure is set at the bottom of the centrifuge. When a single centrifuge cup rotates to the magnetic attraction structure position, the suction force of the magnetic attraction structure controls the thin-sheet structure to move close to the magnetic attraction structure, ensuring that the magnetic attraction structure is set directly below the thin-sheet magnetic structure in the final stop state. The thin-sheet magnetic structure drives the centrifuge cup to maintain a vertical state. This setting can ensure that the magnetic attraction structure can attract the thin-sheet magnetic structure to a vertical state. However, because the magnetic structure is a thin-sheet structure, it has little impact on the weight of the centrifuge cup, so a smaller centrifuge can meet the centrifugal force requirements for exosome enrichment.

[0007] Specifically: an automatic centrifuge for vertical centrifuge cup, comprising: A centrifugal cup can rotate from a vertical state to a direction away from the center of the centrifuge. A plurality of centrifugal cups are arranged on a centrifugal turntable, and a centrifugal tube is arranged in the centrifugal cup; The magnetic structure is a thin sheet structure, and a magnetic structure is fixedly arranged at the bottom of each centrifugal cup; A magnetic attraction structure is provided, and is provided in the centrifuge. The magnetic attraction force of the magnetic attraction structure attracts the magnetic structure to make a magnetic attraction action close to the magnetic attraction structure, and at the same time drives the centrifugal cup fixedly connected to the magnetic structure to rotate. Finally, the movement stop state of the centrifugal cup is the vertical state of the centrifugal cup. The magnetic attraction structure is not provided on the centrifugal turntable; The rotation of the centrifugal turntable drives different centrifugal cups to pass through the magnetic attraction structure. The magnetic attraction structure attracts the magnetic structure at the bottom of each centrifugal cup to produce a magnetic attraction action, so that each centrifugal cup passing through the magnetic attraction structure completes the magnetic attraction action and reaches a vertical state. After the centrifugal turntable rotates 360°, each centrifugal cup remains in a vertical state.

[0008] Furthermore, when the centrifugal cup is in the vertical adjustment state, the centrifugal turntable is controlled to maintain a rotation speed of less than 60° per second, or when each centrifugal cup rotates to above the corresponding position of the magnetic attraction structure, it pauses for 0.5-1s to ensure that there is sufficient time to pull the centrifugal cup straight.

[0009] Furthermore, a verification structure is provided to check whether the centrifugal cup is in a vertical state, so as to avoid the influence of the non-vertical state caused by incomplete magnetic attraction on subsequent operations; specifically, a magnetic sensing structure is provided in the centrifuge, which can only sense the magnetic structure of the centrifugal cup in a vertical state. When the centrifugal cup rotates to the sensing area of ​​the magnetic sensing structure and the centrifugal cup is in a vertical state, the magnetic sensing structure senses the magnetic structure, otherwise the magnetic structure cannot be sensed, proving that the centrifugal cup is not in a vertical state. By providing a magnetic sensing structure, it is possible to effectively monitor whether the centrifugal cup is in a vertical state after the magnetic attraction of the magnetic structure, so as to avoid the non-vertical state caused by insufficient magnetic attraction or failure of the centrifugal cup itself from entering the next process stage and affecting the operation of the equipment.

[0010] Furthermore, when the centrifugal cup rotates to the sensing area of ​​the magnetic sensing structure but the centrifugal cup is not in a vertical state, the magnetic sensing structure cannot sense the magnetic structure, and the centrifugal turntable is controlled to rotate back to the position of the magnetic attraction structure to perform magnetic attraction again, so that the centrifugal cup is in a vertical state, and then rotate to the position of the magnetic sensing structure again; or, label each centrifugal cup, record the number of the centrifugal cup that has not been sensed by the magnetic structure, and after rotating 360° to complete the sensing of all centrifugal cups, perform magnetic attraction again according to the recorded number of the centrifugal cup that has not been sensed, so that the centrifugal cup is in a vertical state again, and then verify whether it is in a vertical state through the magnetic sensing structure.

[0011] Furthermore, when the magnetic structure at the bottom of the centrifuge cup cannot be sensed for the second time, an alarm signal is issued, the operation is stopped, and the corresponding centrifuge cup whose magnetic structure cannot be sensed is checked to ensure that the centrifuge cup has a normal structure.

[0012] Furthermore, the centrifuge is provided with a centrifuge cover, on which an operating port is provided for operating instruments to enter the centrifuge, and a magnetic attraction structure is provided at the centrifuge position where the operating port is located. The purpose of this arrangement is to perform the centrifuge tube taking and placing action under the magnetic attraction of the magnetic attraction structure, so that the centrifuge cup maintains a more stable vertical state, thereby ensuring the stability of the taking and placing operation.

[0013] Furthermore, the centrifugal turntable is rotated clockwise or counterclockwise, and the magnetic induction structure is arranged behind the magnetic attraction structure in the rotation direction, and the interval angle between the two is a multiple of the interval angle between every two centrifugal cups.

[0014] Furthermore, the magnetic induction structures are arranged 180° apart. The purpose of this arrangement is to separate the two structures to facilitate the arrangement of each structure without causing any contamination to each other.

[0015] Furthermore, the magnetic structure is a magnetic sheet attached to the bottom of the centrifuge cup, and the magnetic attraction structure is an electromagnetic suction cup. When the magnetic structure enters above the electromagnetic suction cup, power is turned on to perform magnetic attraction, and power is turned off after the magnetic attraction action is completed. This intermittent power-on and power-off method can avoid unnecessary magnetic attraction operations when the magnetic attraction action is not needed, resulting in the risk of the centrifuge cup in a vertical state being tilted again.

[0016] Furthermore, the inner bottom of the centrifuge cup is set to a plane, and the magnetic sheet is attached to the inner bottom plane of the centrifuge cup. This arrangement can effectively avoid the risk of separation of the magnetic sheet from the centrifuge cup due to long-term centrifugal force during centrifugation.

[0017] Furthermore, the magnetic sensing structure is a Hall sensor. This setting is a common structure for monitoring magnetic structures, but the adjustment of the vertical state of the centrifugal cup and the monitoring of whether it is in a vertical state through the coordination of the Hall sensor, the patch and the electromagnetic suction cup are obviously new and innovative.

[0018] Beneficial effects of the present invention By setting a magnetic attraction structure on the non-centrifugal turntable and cooperating with the magnetic structure in each centrifugal cup, a magnetic attraction action occurs, so that each centrifugal cup can reach a vertical state. The entire process can be achieved by only rotating the centrifugal turntable 360°. Moreover, because the magnetic attraction structure is not set on the centrifugal turntable, the overall weight of the centrifugal turntable during the centrifugal action increases very little. The centrifugal force required for exosome enrichment can be met by a very small centrifugal motor, thereby meeting the miniaturization requirements of the entire exosome enrichment device.

[0019] By setting up a magnetic sensing structure to verify whether the centrifuge cup is in a vertical state, and cooperating with the magnetic attraction structure, it can be further ensured that the centrifuge cup is in a vertical state, avoiding the subsequent operation risks in a non-vertical state caused by inadequate magnetic attraction of the magnetic attraction structure or problems with the centrifuge cup itself.

[0020] By performing two 360° rotations at the magnetic attraction structure position and the magnetic induction structure position respectively, the centrifugal cup can be further ensured to be in a vertical state, and the two 360° rotations make the entire program setting simple.

[0021] By setting an alarm when the magnetic structure cannot be sensed for two consecutive times, timely maintenance of the equipment can be guaranteed, avoiding the risk of more failures in the overall enrichment device due to failure to detect problems in time, and ensuring the accuracy of the exosome enrichment amount.

[0022] By arranging the magnetic structure at the bottom of the inner side of the centrifuge cup, the risk of device failure caused by the separation of the magnetic structure and the centrifuge cup under the action of strong centrifugal force can be avoided. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 It is a schematic diagram of the overall longitudinal cross-sectional structure of the centrifuge of the present invention; Figure 2 It is a partial enlarged structural schematic diagram of part A of the centrifuge as a whole of the present invention; Figure 3 It is a partial enlarged structural schematic diagram of part B of the centrifuge as a whole of the present invention; Figure 4 It is a schematic diagram of the overall structure of the coverless centrifuge of the present invention; Figure 5 This is a schematic diagram of the overall structure of the centrifuge with a cover of the present invention; Description of main reference numerals 1. Centrifugal turntable; 11. Setting hole; 111. Press block; 12. Centrifugal cup; 2. Magnetic structure; 3. Magnetic attraction structure; 4. Magnetic induction structure; 5. Centrifuge cover; 51. Operation port; 6. Centrifuge outer cabin; 61. Centrifugal motor; 7. Centrifuge tube. DETAILED DESCRIPTION

[0024] A centrifuge for automatically verticalizing a centrifuge cup 12, comprising a centrifuge cup 12, which can rotate from a vertical state to a direction away from the center of the centrifuge, a plurality of centrifuge cups 12 are arranged on a centrifuge turntable 1, and a centrifuge tube 7 is arranged in the centrifuge cup 12; a magnetic structure 2 is a thin sheet structure, and a magnetic structure 2 is fixed at the bottom of each centrifuge cup 12; It also includes a magnetic attraction structure 3, which is set up and arranged in the centrifuge. The magnetic attraction force of the magnetic attraction structure 3 attracts the magnetic structure 2 to perform a magnetic attraction action close to the magnetic attraction structure 3, and at the same time drives the centrifugal cup 12 fixedly connected to the magnetic structure 2 to rotate. Finally, the movement stop state of the centrifugal cup 12 is the vertical state of the centrifugal cup 12. The magnetic attraction structure 3 is not set on the centrifugal turntable 1; the centrifugal turntable 1 rotates to drive different centrifugal cups 12 to pass through the magnetic attraction structure 3, and the magnetic attraction structure 3 attracts the magnetic structure 2 at the bottom of each centrifugal cup 12 to perform a magnetic attraction action, so that each centrifugal cup 12 passing through the magnetic attraction structure 3 completes the magnetic attraction action and reaches a vertical state. After the centrifugal turntable 1 rotates 360°, each centrifugal cup 12 is maintained in a vertical state.

[0025] A more preferred embodiment is that when the centrifugal cup 12 is in the vertical adjustment state, the centrifugal turntable 1 is controlled to maintain a rotation speed of less than 60° per second, or when each centrifugal cup 12 rotates to above the corresponding position of the magnetic attraction structure 3, it pauses for 0.5-1s to ensure that there is sufficient time to straighten the centrifugal cup 12.

[0026] A more preferred embodiment is to set a magnetic sensing structure 4 in the centrifuge, which can only sense the magnetic structure 2 of the centrifugal cup 12 in the vertical state. When the centrifugal cup 12 rotates to the sensing area of ​​the magnetic sensing structure 4 and the centrifugal cup 12 is in the vertical state, the magnetic sensing structure 4 senses the magnetic structure 2, and the centrifugal turntable 1 rotates to make the next centrifugal cup 12 enter the sensing area of ​​the magnetic sensing structure 4 to verify whether the centrifugal cup 12 is in the vertical state; the verification is carried out in sequence until all the centrifugal cups 12 are verified to be in the vertical state, and then the next operation stage is entered.

[0027] A more preferred implementation is that when the centrifugal cup 12 rotates to the sensing area of ​​the magnetic sensing structure 4, but the centrifugal cup 12 is not in a vertical state, the magnetic sensing structure 4 cannot sense the magnetic structure 2, and the centrifugal turntable 1 is controlled to rotate back to the position of the magnetic attraction structure 3 to perform the magnetic attraction action again, so that the centrifugal cup 12 is in a vertical state, and then rotates to the position of the magnetic sensing structure 4 again; or, each centrifugal cup 12 is numbered, and the number of the centrifugal cup 12 that is not sensed by the magnetic structure 2 is recorded. After rotating 360° to complete the sensing of all centrifugal cups 12, the magnetic attraction action is performed again according to the recorded number of the centrifugal cup 12 that is not sensed, so that the centrifugal cup 12 is in a vertical state again, and then the vertical state is verified by the magnetic sensing structure 4.

[0028] A more preferred embodiment is that when the magnetic structure 2 at the bottom of the centrifuge cup 12 cannot be sensed for the second time, an alarm signal is issued, the operation is stopped, and the corresponding centrifuge cup 12 that cannot sense the magnetic structure 2 is checked to ensure that the centrifuge cup 12 has a normal structure.

[0029] A more preferred embodiment is to label all the centrifugal cups 12, control the centrifugal cup 12 with the number one to be above the magnetic attraction structure 3, rotate 360° according to the program direction, and perform magnetic attraction on each centrifugal cup 12 on the centrifugal turntable 1 in turn, so that the centrifugal cup 12 is in a vertical state. While rotating, when the first centrifugal cup completes the magnetic attraction action and enters the induction area of ​​the magnetic induction structure 4, the induction action is triggered, and rotate 360° according to the program; complete the vertical state of all centrifugal cups 12 after the magnetic attraction action. During the verification of the state, the number of the centrifugal cup 12 that is not sensed to be in the vertical state is recorded, and after the first round of 360° verification is completed; the centrifugal cup 12 that is not sensed in the vertical state is rotated to the top of the magnetic attraction structure 3 again in turn to perform the magnetic attraction action again, and after the magnetic attraction action, it is rotated to the induction area of ​​the magnetic induction structure 4 again, and the magnetic attraction action is completed again in the second round of 360° rotation of the magnetic induction structure 4, and finally the centrifugal cup 12 with the number one is controlled to be above the magnetic attraction structure 3, and the magnetic attraction structure 3 is turned on. After the above two rounds of magnetic attraction and verification of whether it is in the vertical state, all the centrifugal cups 12 are in the vertical state, and the centrifugal cup 12 with the number one is used as the starting point to start the next stage of the centrifuge tube 7. If there are still centrifugal cups 12 that are not sensed in the vertical state after two rounds of 360° rotation, the inspection is stopped. Through two rounds of 360° rotation, it is very convenient to record and operate, and the whole program runs very smoothly.

[0030] A more preferred embodiment is that the centrifuge is provided with a centrifuge cover 5, and an operating port 51 for operating instruments to enter the centrifuge is provided on the cover. The magnetic attraction structure 3 is provided at the centrifuge position where the operating port 51 is located. The purpose of this arrangement is to perform the taking and placing action of the centrifuge tube 7 under the magnetic attraction of the magnetic attraction structure 3, so that the centrifuge cup 12 maintains a more stable vertical state, thereby ensuring the stability of the taking and placing operation.

[0031] A more preferred embodiment is that the centrifugal turntable 1 is rotated clockwise or counterclockwise, and the magnetic sensing structure 4 is arranged behind the magnetic attraction structure 3 in the rotation direction, and the spacing angle between the two is a multiple of the spacing angle between every two centrifugal cups 12.

[0032] A more preferred embodiment is that the magnetic induction structures 4 are arranged 180° apart. The purpose of this arrangement is to separate the two structures to facilitate the arrangement of each structure without causing contamination to each other.

[0033] A more preferred embodiment is that the magnetic structure 2 is a magnetic sheet attached to the bottom of the centrifuge cup 12, and the magnetic attraction structure 3 is an electromagnetic suction cup. When the magnetic structure 2 enters above the electromagnetic suction cup, power is turned on to perform magnetic attraction, and the power is turned off after the magnetic attraction action is completed. This intermittent power-on and power-off method can avoid the risk of unnecessary magnetic attraction operation when the magnetic attraction action is not needed, resulting in the centrifuge cup 12 in a vertical state being tilted again.

[0034] A more preferred embodiment is that the inner bottom of the centrifuge cup 12 is set to a plane, and the magnetic sheet is attached to the inner bottom plane of the centrifuge cup 12. This arrangement can effectively avoid the risk of separation of the magnetic sheet from the centrifuge cup 12 due to long-term centrifugal force during centrifugation.

[0035] A more preferred embodiment is that the magnetic sensing structure 4 is a Hall sensor. This setting is a common structure for monitoring the magnetic structure 2, but the adjustment of the vertical state of the centrifugal cup 12 and the monitoring of whether it is in a vertical state through the cooperation of the Hall sensor, the patch and the electromagnetic suction cup are obviously innovative.

[0036] A more preferred embodiment is that the centrifugal turntable 1 has a closed bottom structure and a thin bottom structure, which will not interfere with the magnetic attraction and induction force of the electromagnetic chuck and the Hall sensor on the magnetic sheet. The closed centrifugal turntable 1 can effectively avoid the formation of an air duct in the centrifugal chamber, causing large centrifugal noise.

[0037] A more preferred embodiment is that the outer side of the centrifugal turntable 1 is a centrifuge outer cabin 6, a centrifugal motor 61 is arranged in the middle of the centrifuge outer cabin 6, and a magnetic attraction structure 3 and a Hall sensor are arranged at the corresponding position of the bottom of the centrifuge outer cabin 6. This arrangement can ensure the effective rotation of the centrifugal turntable 1, and the magnetic attraction structure 3 and the Hall sensor are not arranged on the centrifugal turntable 1, which can reduce the weight of the centrifugal turntable 1 to the greatest extent, and the weight of the centrifugal turntable 1 will not be increased by adding a structure to ensure that the centrifugal cup 12 is in a vertical state. In order to achieve the vertical state of the centrifugal cup 12, only a little weight of the magnetic sheet is added to the centrifugal turntable 1, and this weight is very small and can be ignored.

[0038] A more preferred embodiment is that a plurality of holes 11 for setting centrifugal cups 12 are arranged on the centrifugal turntable 1, the holes 11 are arranged with high edges and a bottom in the middle, and are elliptical when viewed from above. The width of the ellipse is adapted to the outer diameter of the centrifugal cup 12. This arrangement enables the centrifugal cup 12 to rotate only along the long side direction of the ellipse, and all magnetic suction actions only control the rotation of the centrifugal cup 12 in the long side direction.

[0039] A more preferred embodiment is that a rotating shaft is provided on the centrifugal cup 12, an axial hole adapted to the rotating shaft is provided on the setting hole 11, and a pressing block 111 is provided on the setting hole 11 to limit the rotating shaft of the centrifugal cup 12 in the axial hole. By providing the pressing block 111, the centrifugal cup 12 can be well stabilized at the setting hole 11.

[0040] During use, when the centrifuge tube 7 needs to be transferred to the centrifuge cup 12, the centrifuge turntable 1 is rotated at a relatively slow speed, and the centrifuge cup 12 marked with one is stopped when it rotates to the magnetic attraction structure 3, and the magnetic attraction structure 3 is started to magnetically attract the centrifuge cup 12, so that the centrifuge cup 12 reaches a vertical state, and then the magnetic attraction structure 3 is stopped, and the centrifuge turntable 1 is rotated to transport the next centrifuge cup 12 to the position of the magnetic attraction structure 3, and the previous round of actions is repeated until it rotates 360° to complete a round of magnetic attraction operation. Alternatively, a relatively low-speed rotation can be maintained, and the low-speed rotation process does not affect the magnetic attraction action. During the process, when the centrifugal cup 12 labeled as one enters the corresponding area of ​​the magnetic sensing structure 4 and completes the sensing action, record whether the corresponding centrifugal cup 12 is in a vertical state. After rotating 360 degrees, complete a round of vertical state verification. When all centrifugal cups 12 are in a vertical state, move the centrifugal cup 12 labeled as one to the corresponding position of the magnetic attraction structure 3, and turn on the magnetic attraction structure 3. When the magnetic attraction structure 3 is in the working state, send the centrifuge tube 7 into the centrifuge cup 12 through the operating port 51 on the centrifugal cover body, then stop the magnetic attraction structure 3, rotate the centrifugal turntable 1, and send the next centrifugal cup 12 to the position of the magnetic attraction structure 3. Repeat the previous round of actions until the centrifuge tube 7 is placed in all the centrifuge cups 12 after rotating 360 degrees.

[0041] Similarly, when the centrifuge tube 7 needs to be transferred out of the centrifuge cup 12, firstly, all the centrifuge cups 12 are placed in a vertical state according to the above-mentioned actions. After completion, all the centrifuge tubes 7 are moved out of the centrifuge cup 12 starting from the centrifuge cup 12 labeled one.

[0042] The technical solutions in the embodiments of the present invention are clearly and completely described above through specific embodiments. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Those skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. The present invention can also be implemented or applied through other different specific implementation methods. In the absence of conflict, the above embodiments and features in the embodiments can be combined with each other. Based on the embodiments in the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

Claims

1. An automatic centrifuge for vertical centrifuge cup, comprising: A centrifugal cup can rotate from a vertical state to a direction away from the center of the centrifuge, wherein a plurality of centrifugal cups are arranged on a centrifugal turntable and a centrifugal tube is arranged inside the centrifugal cup; the characteristics are as follows: The magnetic structure is a thin sheet structure, and a magnetic structure is fixed at the bottom of each centrifugal cup; A magnetic attraction structure is provided, and is provided in the centrifuge. The magnetic attraction force of the magnetic attraction structure attracts the magnetic structure to make a magnetic attraction action close to the magnetic attraction structure, and at the same time drives the centrifugal cup fixedly connected to the magnetic structure to rotate. Finally, the movement stop state of the centrifugal cup is the vertical state of the centrifugal cup. The magnetic attraction structure is not provided on the centrifugal turntable; The rotation of the centrifugal turntable drives different centrifugal cups to pass through the magnetic attraction structure. The magnetic attraction structure attracts the magnetic structure at the bottom of each centrifugal cup to produce a magnetic attraction action, so that each centrifugal cup passing through the magnetic attraction structure completes the magnetic attraction action and reaches a vertical state. After the centrifugal turntable rotates 360°, each centrifugal cup remains in a vertical state.

2. The centrifuge according to claim 1, characterized in that When the centrifugal cup is in the vertical adjustment state, the centrifugal turntable is controlled to maintain a rotation speed of less than 60° per second, or when each centrifugal cup rotates to above the corresponding position of the magnetic attraction structure, it pauses for 0.5-1s.

3. The centrifuge according to claim 1, characterized in that A magnetic sensing structure is set in the centrifuge to monitor whether the centrifuge cup is in a vertical state by detecting whether the magnetic structure can be detected; it can only sense the magnetic structure of the centrifuge cup in a vertical state. When the centrifuge cup rotates to the sensing area of ​​the magnetic sensing structure and the centrifuge cup is in a vertical state, the magnetic sensing structure senses the magnetic structure. Otherwise, the magnetic structure cannot be sensed, indicating that the centrifuge cup is not in a vertical state.

4. The centrifuge according to claim 3, characterized in that When the centrifugal cup rotates to the sensing area of ​​the magnetic sensing structure, but the centrifugal cup is not in a vertical state, the magnetic sensing structure cannot sense the magnetic structure, and the centrifugal turntable is controlled to rotate back to the position of the magnetic attraction structure to perform magnetic attraction again, so that the centrifugal cup is in a vertical state, and then rotate to the position of the magnetic sensing structure again; alternatively, label each centrifugal cup, record the number of the centrifugal cup that is not sensed by the magnetic structure, and after rotating 360° to complete the sensing of all centrifugal cups, perform magnetic attraction again according to the recorded number of the centrifugal cup that is not sensed, and then verify whether it is in a vertical state through the magnetic sensing structure.

5. The centrifuge according to claim 4, characterized in that When the magnetic structure at the bottom of the centrifuge cup cannot be sensed for the second time, an alarm signal is issued and the operation is stopped.

6. The centrifuge according to claim 3, characterized in that: All centrifugal cups are numbered, and the centrifugal cup numbered one is controlled to be above the magnetic attraction structure, rotated 360° in the program direction, and magnetic attraction is performed on each centrifugal cup on the centrifugal turntable in turn, so that the centrifugal cup is in a vertical state; when the first centrifuge completes the magnetic attraction action and enters the induction area of ​​the magnetic induction structure, the induction action is triggered, and the centrifugal cup is rotated 360° in accordance with the program; the verification of whether all centrifugal cups that have passed the magnetic attraction action are in a vertical state is completed, and the numbers of the centrifugal cups that are not sensed to be in a vertical state are recorded during the process, and after the first round of 360° verification is completed; the centrifugal cups that are not sensed to be in a vertical state are rotated to the top of the magnetic attraction structure in turn again to perform the magnetic attraction action again, and after the magnetic attraction action, they are rotated to the induction area of ​​the magnetic induction structure again, and the magnetic attraction action is completed again in the second round of 360° rotation of the magnetic induction structure, and finally the centrifugal cup numbered one is controlled to be above the magnetic attraction structure, and the magnetic attraction structure is turned on.

7. The centrifuge according to claim 1, characterized in that The centrifuge is provided with a centrifuge cover body, the cover body is provided with an operating port for operating instruments to enter the centrifuge, and the magnetic attraction structure is arranged at the centrifuge position where the operating port is located.

8. The centrifuge according to claim 3, characterized in that The centrifugal turntable is rotated clockwise or counterclockwise, and the magnetic induction structure is arranged behind the magnetic attraction structure in the rotation direction, and the interval angle between the two is a multiple of the interval angle between every two centrifugal cups; Preferably, the magnetic induction structures are arranged 180° apart.

9. The centrifuge according to claim 3, characterized in that: The magnetic structure is a magnetic sheet attached to the bottom of the centrifugal cup, and the magnetic suction structure is an electromagnetic suction cup. When the magnetic structure enters above the electromagnetic suction cup, power is turned on to perform magnetic suction, and power is turned off after the magnetic suction action is completed; the magnetic sensing structure is a Hall sensor; Preferably, the inner bottom of the centrifuge cup is set to be a plane, and the magnetic sheet is attached to the inner bottom plane of the centrifuge cup.

10. The centrifuge according to claim 3, characterized in that: The centrifugal turntable has a closed bottom structure and a thin bottom structure. The thin bottom structure will not interfere with the magnetic attraction and induction force of the electromagnetic chuck and the Hall sensor on the magnetic sheet. Preferably, the outer side of the centrifugal turntable is a centrifuge outer cabin, a centrifugal motor is arranged in the middle of the centrifuge outer cabin, and a magnetic attraction structure and a Hall sensor are arranged at corresponding positions of the bottom of the centrifuge outer cabin; Preferably, a plurality of centrifugal cup setting holes are arranged on the centrifugal turntable, the setting holes are high at the edges and low in the middle, and are elliptical when viewed from above, and the width of the ellipse is adapted to the outer diameter of the centrifugal cup; Preferably, a rotating shaft is arranged on the centrifugal cup, an axial hole matching the rotating shaft is arranged on the setting hole, and a pressing block for limiting the rotating shaft of the centrifugal cup within the axial hole is arranged on the setting hole.

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