Blood pump and blood pump system for veins

Abstract

The invention discloses a blood pump and a blood pump system for veins. The blood pump comprises a catheter body used for being deployed in a venous blood tube through a puncture surgery; the flow choking part is arranged on the outer side of the catheter body and is jointly placed into the venous blood tube in the first area along with the catheter body, so that the flow choking effect on blood in the venous blood tube in the first area is achieved; and the axial flow pump is arranged on the catheter body in a sleeving manner, so that the axial flow pump and the catheter body are jointly placed into the venous blood tube in the second area, and the acceleration effect on the blood in the venous blood tube in the second area is achieved. Wherein the second area is located in front of the first area in the blood flowing direction, so that blood can flow through the vein blood vessels of the second area from the vein blood vessels of the first area and flow to the right atrium. By means of the blood pump, a low-pressure area can be created in a preset area to promote the flow of lymph, so that the discharge capacity of the lymph is enhanced, and the accumulation of liquid in tissue gaps is reduced.

Description

Technical Field

[0001] The invention relates to a blood pump for a venous blood vessel and also to a corresponding blood pump system, belonging to the technical field of medical devices. Background Art

[0002] With the aging and growth of the population, the number of patients with end-stage heart disease continues to increase. Among these heart failure patients, 5% will progress to severe heart failure each year. For severe heart failure, drug treatment is not effective, and heart transplantation and artificial hearts have become the most powerful means to treat patients with severe heart failure. Due to donor and technical limitations, the number of heart transplants worldwide has grown slowly because of the limited supply of hearts and a large number of heart patients die while waiting for heart transplants.

[0003] Patients with acute decompensated heart failure (ADHF) experience symptoms of shortness of breath, fatigue, and edema (swelling) due to fluid accumulation (congestion) in the lungs and other parts of the body. Most fluid accumulates in tissues, and there is usually no way to actively target and remove this fluid, except by taking diuretics to promote its removal. Complete resolution of congestion is the goal of ADHF treatment because residual congestion at discharge is the strongest predictor of readmission and death. Up to half of ADHF patients are discharged from the hospital without complete resolution of congestion, and a quarter of ADHF patients are readmitted to the hospital within a month.

[0004] In healthy individuals, the lymphatic system continuously captures fluid from tissues throughout the body and pumps it back to the vascular system to maintain homeostasis. In ADHF, excess fluid accumulates in the body's tissues (interstitial compartment), leading to edema and increased venous blood pressure. Excess tissue fluid and high venous blood pressure interfere with the lymphatic system's ability to move fluid back to the vascular system, further exacerbating congestion.

[0005] Therefore, how to help ADHF patients reduce the accumulation of fluid in the tissue spaces is a technical problem that needs to be solved urgently. Summary of the invention

[0006] The primary technical problem to be solved by the present invention is to provide a blood pump for a venous blood vessel.

[0007] Another technical problem to be solved by the present invention is to provide a blood pump system including the above-mentioned blood pump.

[0008] In order to achieve the above technical objectives, the present invention adopts the following technical solutions:

[0009] According to a first aspect of an embodiment of the present invention, there is provided a blood pump for a venous blood vessel, comprising:

[0010] The catheter body is a multi-lumen tube, comprising at least a guidewire lumen and a guidewire lumen; wherein a guidewire is inserted into the guidewire lumen for insertion guidance; and a guidewire is inserted into the guidewire lumen for conductive connection;

[0011] The blocking portion is arranged outside the catheter body and can be switched between a contracted state and an expanded state; wherein, in the contracted state, the blocking portion can be inserted into the venous blood vessel of the first area together with the catheter body; in the expanded state, the blocking portion can block or slow down the blood flow in the venous blood vessel of the first area;

[0012] an axial flow pump, which is sleeved on the catheter body and electrically connected to the wire, and the axial flow pump can be switched between a retracted state and an expanded state; wherein, in the retracted state, the axial flow pump can be placed into the venous blood vessel of the second region together with the catheter body; and in the expanded state, the axial flow pump can pump blood in the venous blood vessel of the second region to accelerate the blood flow in the venous blood vessel of the second region;

[0013] Wherein, along the direction of blood flow, the second area is located in front of the first area, so that blood can flow from the venous blood vessels of the first area through the venous blood vessels of the second area and flow to the right atrium.

[0014] Preferably, there are multiple flow blocking parts, and the multiple flow blocking parts are arranged at intervals along the length direction of the catheter body and are all located on the same side of the axial flow pump.

[0015] Preferably, the flow blocking portion at least includes: an inflatable / liquid-filled balloon, or a flow blocking structure woven from metal wires / polymer materials into a preset shape.

[0016] Preferably, there are multiple axial flow pumps, which are spaced apart along the length direction of the catheter body and are all located on the same side of the flow blocking portion.

[0017] Preferably, a control valve is provided on the flow blocking portion, and the control valve is electrically connected to an external controller via the wire, and the controller can control the opening amplitude of the control valve to control the blood flow velocity of the veins in the first area.

[0018] Preferably, a one-way valve is provided on the flow blocking portion;

[0019] When the suction force of the axial flow pump is within a preset range, the one-way valve remains closed to play a blocking role;

[0020] When the suction force of the axial flow pump exceeds the preset range, the one-way valve opens to allow the blood in the first area to flow to the second area.

[0021] Preferably, at least one flow blocking part is respectively provided at both ends of the axial flow pump;

[0022] Wherein, along the blood flow direction, the flow blocking portion at one end of the axial flow pump is used for blood to enter, and the flow blocking portion at the other end of the axial flow pump is used for blood to be discharged.

[0023] Preferably, the blood pump further comprises:

[0024] Pressure sensors are respectively arranged on the flow blocking portion and the axial flow pump to monitor the blood flow pressure in the first area and the second area respectively.

[0025] Preferably, there is a preset distance between the axial flow pump and the flow blocking portion, and the preset distance is 1 to 1000 mm.

[0026] According to a second aspect of an embodiment of the present invention, there is provided a blood pump system, comprising the above-mentioned blood pump.

[0027] Compared with the prior art, the present invention has the following technical effects:

[0028] (1) A blood pump is placed into a vein through minimally invasive surgery, so that the blocking part is placed into the vein of the first region together with the catheter body, thereby achieving a blocking effect on the blood in the vein of the first region. In addition, the axial flow pump is placed into the vein of the second region together with the catheter body, thereby achieving an acceleration effect on the blood in the vein of the second region. Thus, by blocking the flow of the first region and accelerating the blood pumping in the second region, a low pressure is formed near the second region, so as to promote the flow of lymph, enhance the discharge capacity of lymph, and help reduce the accumulation of fluid in the interstitial space.

[0029] (2) By reducing fluid overload and venous pressure, it improves blood supply to the kidneys, thereby helping to maintain and improve renal function.

[0030] (3) Promoting fluid excretion through non-drug means reduces the need for diuretics, thereby reducing the renal damage that may be caused by diuretics. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 This is a diagram of an actual application scenario of a venous blood pump in an embodiment of the present invention;

[0032] Figure 2 A schematic structural diagram of a blood pump for a venous blood vessel provided by a first embodiment of the present invention;

[0033] Figure 3 is a cross-sectional view of a catheter body in a first embodiment of the present invention;

[0034] Figure 4 A schematic structural diagram of a blood pump for a venous blood vessel provided in a second embodiment of the present invention;

[0035] Figure 5 A schematic structural diagram of a blood pump for a venous blood vessel provided in a third embodiment of the present invention;

[0036] Figure 6 A schematic structural diagram of another blood pump for a venous blood vessel provided in the fourth embodiment of the present invention. DETAILED DESCRIPTION

[0037] The technical content of the present invention is described in detail below with reference to the accompanying drawings and specific embodiments.

[0038] The present invention provides a blood pump for venous vessels, which is intended to promote the removal of excess fluid from tissues and organs (interstitial fluid) of ADHF patients by supporting the ability of the lymphatic system to actively drain fluid. Figure 1 As shown in the figure, a low-pressure area is created in a preset area (e.g., the thoracic duct area) through minimally invasive surgery to promote the flow of lymph. A low-pressure environment is created in the thoracic duct area (located at the bifurcation of the left jugular vein and subclavian vein) through a blood pump. This low-pressure area can enhance the drainage capacity of lymph and help alleviate the accumulation of fluid in the interstitial space.

[0039] Thus, the low-pressure environment created in the preset area increases the pressure difference between the inside and outside of the lymphatic vessels, promoting the flow of lymph fluid to the venous system. In addition, the drainage resistance of the lymphatic system is reduced by decompression, allowing the lymphatic system to more effectively process and discharge excess tissue fluid, thereby alleviating tissue edema.

[0040] First embodiment

[0041] like Figure 2As shown, a blood pump for a venous blood vessel provided by the first embodiment of the present invention comprises a catheter body 1, a flow blocking portion 2 and an axial flow pump 3. The catheter body 1 is used to be deployed in a venous blood vessel through a puncture operation. The flow blocking portion 2 is arranged on the outside of the catheter body 1, so as to be inserted into the venous blood vessel of the first area together with the catheter body 1, thereby achieving a flow blocking effect on the blood in the venous blood vessel of the first area. The axial flow pump 3 is sleeved on the catheter body 1, so as to be inserted into the venous blood vessel of the second area together with the catheter body 1, thereby achieving an acceleration effect on the blood in the venous blood vessel of the second area. In the direction of blood flow, the second area is located in front of the first area, so that blood can flow from the venous blood vessel of the first area through the venous blood vessel of the second area, and flow to the right atrium.

[0042] like Figure 3 As shown, in this embodiment, the catheter body 1 is a multi-lumen tube. The catheter body 1 includes at least a guidewire cavity 101 and a guidewire cavity 102. A guidewire 10 is inserted into the guidewire cavity 101 for insertion guidance; a guidewire 20 is inserted into the guidewire cavity 102 for conductive connection. On this basis, the catheter body 1 may also include other cavity structures, such as an air guide cavity or a liquid guide cavity, etc., which may be adaptively set according to needs.

[0043] like Figure 2 As shown, in the present embodiment, the flow blocking portion 2 is a balloon sleeved on the outside of the catheter body 1, and can be switched between a contracted state and an expanded state. When the balloon is in a contracted state, the balloon can be placed into the venous blood vessel of the first region together with the catheter body 1. Subsequently, as the balloon is continuously inflated or filled with liquid, the balloon gradually switches from a contracted state to an expanded state, so as to use the expanded balloon to completely block or reduce the blood flow in the venous blood vessel of the first region as needed. In the present embodiment, the purpose of using the flow blocking portion 2 for flow blocking is to avoid excessive reduction of blood flow in the brain during the operation of the axial flow pump 3, thereby avoiding safety hazards caused by cerebral ischemia. It can be understood that the provision of the flow blocking portion 2 is a safety measure that can ensure normal blood circulation in the brain (blood flow can also be completely blocked under special circumstances), thereby ensuring the safety of the blood pump operation.

[0044] like Figure 2 As shown, in this embodiment, the axial flow pump 3 is sleeved on the catheter body 1 and electrically connected to the wire 20, and the axial flow pump 3 can switch between a retracted state and an expanded state. When the axial flow pump 3 is in the retracted state, the axial flow pump 3 can be placed into the venous blood vessel of the second region together with the catheter body 1, and then the axial flow pump 3 gradually expands, thereby rotating and sucking the blood in the venous blood vessel in the second region, thereby creating a low-pressure environment near the second region, so as to accelerate the blood flow in the venous blood vessel of the second region, enhance the discharge capacity of lymph fluid, and help reduce the accumulation of fluid in the interstitial space.

[0045] In one embodiment of the present invention, the venous blood vessel in the first region is the internal jugular vein, and the venous blood vessel in the second region is the superior vena cava. The working principle of the blood pump is described in detail below:

[0046] ① The blood pump percutaneously punctures the external jugular vein, enters the internal jugular vein, and reaches the opening of the subclavian vein and superior vena cava (ie, the thoracic duct area).

[0047] ②Balloon occlusion of the unilateral internal jugular vein (eg Figure 1 Only the left internal jugular vein was occluded in order to stabilize the blood pump and prevent cerebral ischemia.

[0048] ③ The blades of the axial flow pump 3 are unfolded in the superior vena cava and begin to rotate to pump blood.

[0049] ④ Because the internal jugular vein is blocked, blood cannot be drawn from the brain. Therefore, the direction of blood flow is to pump blood from the subclavian vein into the superior vena cava.

[0050] ⑤Affected by the negative pressure generated by the fluid, the blood flow in the internal jugular vein and subclavian vein on the other side will also be affected, accelerating into the superior vena cava.

[0051] ⑥ The blood filling the superior vena artery creates high pressure, which accelerates the blood into the right atrium and right ventricle, thereby accelerating systemic circulation.

[0052] It is understood that any factor that increases the effective filtration pressure of the capillaries will increase lymphatic flow. Increasing venous pressure, and thus capillary pressure, is particularly effective in increasing lymphatic flow; and the flow of lymphatic fluid, in turn, reduces the accumulation of excess fluid in the interstitial compartment, reducing edema.

[0053] In the above embodiment, preferably, the blood pump further comprises a pressure sensor. The pressure sensor is respectively arranged on the flow blocking part 2 and the axial flow pump 3 to monitor the blood flow pressure in the first area and the second area respectively. And, preferably, there is a preset distance between the flow blocking part 2 and the axial flow pump 3, and the preset distance is 1 to 1000 mm.

[0054] Second embodiment

[0055] like Figure 4 As shown, based on the above first embodiment, the second embodiment of the present invention provides another blood pump for venous blood vessels, including a catheter body 1, a flow blocking portion 2 and an axial flow pump 3. Compared with the first embodiment, the difference of this embodiment is that there are multiple flow blocking portions 2.

[0056] Specifically, in this embodiment, a plurality of flow blocking parts 2 are arranged at intervals along the length direction of the catheter body 1 and are all located on the same side of the axial flow pump 3. Each flow blocking part 2 adopts an inflatable or liquid-filled balloon to improve the blood flow blocking effect by multi-stage blocking.

[0057] For example, in a preferred embodiment of the present invention, multiple balloons can be expanded to different degrees, so that each balloon has a different blocking effect on the blood flow. Therefore, when the blood flows, it will be subject to different resistances when passing through different balloons, thereby blocking the blood flow in a gradient manner, thereby improving the blocking effect on the blood flow.

[0058] Except for the above differences, the rest of the structure of this embodiment is the same as that of the first embodiment and will not be described again.

[0059] Third embodiment

[0060] like Figure 5 As shown, based on the above first embodiment, the third embodiment of the present invention provides another blood pump for venous blood vessels, including a catheter body 1, a flow blocking portion 2 and an axial flow pump 3. Compared with the first embodiment, the difference of this embodiment is that there are multiple axial flow pumps 3.

[0061] Specifically, in this embodiment, multiple axial flow pumps 3 are arranged at intervals along the length direction of the catheter body 1 and are all located on the same side of the flow blocking portion 2. Thus, multiple axial flow pumps 3 are used to perform multi-stage blood pumping on the blood in the veins of the second region to improve the blood pumping efficiency.

[0062] It is understandable that if the catheter body 1 is only provided with a single axial flow pump 3, a very high rotation speed and blade area are required to achieve a suitable flow rate, which may easily cause hemolysis or other organ damage. In this embodiment, a large axial flow pump with a high rotation speed and large blades is decomposed into a plurality of small axial flow pumps with low rotation speed and small blades, thereby reducing the risk of hemolysis, reducing the overall size of the axial flow pump, and making it easier to place the axial flow pump 3 into the blood vessel.

[0063] Except for the above differences, the rest of the structure of this embodiment is the same as that of the first embodiment and will not be described again.

[0064] Fourth embodiment

[0065] like Figure 6 As shown, based on the above-mentioned first embodiment, the fourth embodiment of the present invention provides another blood pump for a venous blood vessel, comprising a catheter body 1, a flow blocking portion 2 and an axial flow pump 3. Compared with the first embodiment, the difference of this embodiment is that at least one flow blocking portion 2 is respectively provided at both ends of the axial flow pump 3.

[0066] Specifically, in this embodiment, along the blood flow direction, the flow block 2 at one end of the axial flow pump 3 is used to enter the blood, and the flow block 2 at the other end of the axial flow pump 3 is used to discharge the blood. It can be understood that in this embodiment, the flow block 2 at both ends of the axial flow pump 3 is equivalent to forming a flow block valve, so that by opening and closing the flow block valve, the blood flow blockage control and blood flow output control can be performed according to actual needs.

[0067] Except for the above differences, the rest of the structure of this embodiment is the same as that of the first embodiment and will not be described again.

[0068] Fifth embodiment

[0069] Based on the first embodiment, the fifth embodiment of the present invention provides another blood pump for venous blood vessels, comprising a catheter body 1, a flow blocking portion 2 and an axial flow pump 3. Compared with the first embodiment, the difference of this embodiment is that the flow blocking portion 2 is provided with a control valve.

[0070] Specifically, the control valve is electrically connected to an external controller via a wire 20, and the controller can control the opening amplitude of the control valve, thereby controlling the blood flow velocity of the venous blood vessels in the first area.

[0071] It can be understood that by using the controller to control the opening size of the control valve, different flow blocking effects on the venous blood vessels in the first area can be achieved to adapt to different usage scenarios.

[0072] Except for the above differences, the rest of the structure of this embodiment is the same as that of the first embodiment and will not be described again.

[0073] Sixth embodiment

[0074] Based on the first embodiment, the sixth embodiment of the present invention provides another blood pump for venous blood vessels, comprising a catheter body 1, a flow blocking portion 2 and an axial flow pump 3. Compared with the first embodiment, the difference of this embodiment is that the flow blocking portion 2 is provided with a one-way valve.

[0075] Specifically, in the present embodiment, the flow-blocking portion 2 is woven from metal wires (preferably nickel-titanium alloy wires) or polymer materials into a flow-blocking structure of a preset shape. In addition, a diaphragm of a polymer material (preferably TPU) is attached to the flow-blocking structure, so that a one-way valve is formed by the diaphragm. When the suction force of the axial flow pump is within a preset range, the one-way valve remains closed to play a blocking role; when the suction force of the axial flow pump exceeds the preset range, the one-way valve opens to allow blood in the first area to flow to the second area. Thus, by performing a special structural design on the flow-blocking portion 2, the potential safety hazard caused by excessive suction force of the axial flow pump 3 can be avoided.

[0076] Except for the above differences, the rest of the structure of this embodiment is the same as that of the first embodiment and will not be described again.

[0077] Seventh embodiment

[0078] On the basis of the above first to sixth embodiments, a seventh embodiment of the present invention provides a blood pump system, which includes any one of the blood pumps in the above first to sixth embodiments.

[0079] It should be noted that the above embodiments are only examples, and the technical solutions of the various embodiments can be combined, all within the protection scope of the present invention.

[0080] It should be understood that the orientation or positional relationship indicated by the terms "upper" and "lower" etc. is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0081] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0082] The above is a detailed description of the blood pump and blood pump system for venous blood vessels provided by the present invention. For those skilled in the art, any obvious changes made to it without departing from the essence of the present invention will constitute an infringement of the patent right of the present invention and will bear corresponding legal responsibilities.

Claims

1. A blood pump for a venous blood vessel, characterized in that include: The catheter body is a multi-lumen tube, comprising at least a guidewire lumen and a guidewire lumen; wherein a guidewire is inserted into the guidewire lumen for insertion guidance; and a guidewire is inserted into the guidewire lumen for conductive connection; The blocking portion is arranged outside the catheter body and can be switched between a contracted state and an expanded state; wherein, in the contracted state, the blocking portion can be inserted into the venous blood vessel of the first area together with the catheter body; in the expanded state, the blocking portion can block or slow down the blood flow in the venous blood vessel of the first area; an axial flow pump, which is sleeved on the catheter body and electrically connected to the wire, and the axial flow pump can be switched between a retracted state and an expanded state; wherein, in the retracted state, the axial flow pump can be placed into the venous blood vessel of the second region together with the catheter body; and in the expanded state, the axial flow pump can pump blood in the venous blood vessel of the second region to accelerate the blood flow in the venous blood vessel of the second region; Wherein, along the direction of blood flow, the second area is located in front of the first area, so that blood can flow from the venous blood vessels of the first area through the venous blood vessels of the second area and flow to the right atrium.

2. The blood pump according to claim 1, characterized in that: There are multiple flow blocking parts, which are arranged at intervals along the length direction of the catheter body and are all located on the same side of the axial flow pump.

3. The blood pump according to claim 2, characterized in that: The flow blocking part at least includes: an inflatable / liquid-filled balloon, or a flow blocking structure woven from metal wires / polymer materials into a preset shape.

4. The blood pump according to claim 2, characterized in that: There are multiple axial flow pumps, which are arranged at intervals along the length direction of the catheter body and are all located on the same side of the flow blocking portion.

5. The blood pump according to claim 1, characterized in that: The flow blocking portion is provided with a control valve, and the control valve is electrically connected to an external controller through the wire. The controller can control the opening amplitude of the control valve to control the blood flow velocity of the venous blood vessels in the first area.

6. The blood pump according to claim 1, characterized in that: The flow blocking portion is provided with a one-way valve; When the suction force of the axial flow pump is within a preset range, the one-way valve remains closed to play a blocking role; When the suction force of the axial flow pump exceeds the preset range, the one-way valve opens to allow the blood in the first area to flow to the second area.

7. The blood pump according to claim 1, characterized in that: At least one flow blocking part is respectively provided at both ends of the axial flow pump; Wherein, along the blood flow direction, the flow blocking portion at one end of the axial flow pump is used for blood to enter, and the flow blocking portion at the other end of the axial flow pump is used for blood to be discharged.

8. The blood pump according to claim 1, characterized in that Also includes: Pressure sensors are respectively arranged on the flow blocking portion and the axial flow pump to monitor the blood flow pressure in the first area and the second area respectively.

9. The blood pump according to claim 1, characterized in that: There is a preset distance between the axial flow pump and the flow blocking portion, and the preset distance is 1 to 1000 mm.

10. A blood pump system, characterized in that A blood pump comprising the blood pump according to any one of claims 1 to 9.

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