Characterization method for space residue distribution and release rate of nicotine, glycerol and propylene glycol in pyrolysis area in cigarette puff-by-puff pyrolysis process

Abstract

The invention relates to a characterization method for space residue distribution and release rate of nicotine, glycerol and propylene glycol in a pyrolysis area in a cigarette puff-by-puff pyrolysis process. The method is suitable for cigarettes subjected to continuous pyrolysis and puff-by-puff airflow suction, puff-by-puff residue distribution of nicotine, glycerol and propylene glycol under different suction times can be obtained by performing spatial segmentation and layering treatment on a cigarette pyrolysis area after each suction, puff-by-puff release rate distribution of nicotine, glycerol and propylene glycol can be calculated, and the puff-by-puff residue distribution of nicotine, glycerol and propylene glycol can be calculated according to the puff-by-puff release rate distribution. The residue distribution of the whole pyrolysis area is obtained based on data interpolation processing; finally, puff-by-puff residue distribution under different suction times is measured in sequence, the puff-by-puff release rate is calculated, and puff-by-puff release rate distribution is obtained. According to the method, the component release characteristics in the cigarette pyrolysis process can be effectively described, and a scientific basis is provided for researching cigarette pyrolysis behaviors and optimizing product design.

Description

Technical Field

[0001] The invention relates to the technical field of tobacco chemical analysis, and in particular to a method for characterizing the spatial residual distribution and release rate of nicotine, glycerol and propylene glycol in a pyrolysis zone during the puff-by-puff pyrolysis of cigarettes. Background Art

[0002] The use of heat-not-burn cigarettes is a complex pyrolysis process involving the generation and release of thousands of chemical substances. Among them, nicotine, glycerin and propylene glycol are important components in cigarette smoke, which have a significant impact on the sensory quality of cigarettes and the health risks of consumers. Nicotine is the main addictive substance in cigarettes, and its release directly affects the strength and satisfaction of cigarettes; glycerin and propylene glycol, as common humectants, can adjust the pyrolysis state of cigarettes and smoke humidity, affecting the taste and comfort of smoke.

[0003] Traditionally, the analysis of cigarette smoke components has mainly focused on the overall detection of mainstream smoke and sidestream smoke, and lacks information on the spatial distribution of components in the pyrolysis zone. However, the pyrolysis zone is the area where chemical reactions are most intense during the pyrolysis of cigarettes, and its internal temperature gradient and material concentration gradient are significant, and there are significant differences in the distribution of chemical components at different spatial locations. Understanding the spatial residual distribution of nicotine, glycerin, and propylene glycol in the pyrolysis zone has important theoretical significance and application value for in-depth understanding of the pyrolysis mechanism of cigarettes, optimizing cigarette formula design, and reducing cigarette hazards.

[0004] However, the current research on the spatial distribution of components in the pyrolysis zone during the puff-by-puff process of cigarettes is relatively limited. Most studies only focus on the overall component content or specific areas, and lack a detailed analysis of the layered and segmented component distribution. When studying the pyrolysis products of cigarettes, traditional methods mostly use overall or single-partition sampling methods, and fail to fully consider the distribution patterns of components in the pyrolysis zone. This deficiency may lead to deviations in the understanding of the characteristics of cigarette pyrolysis behavior. In response to the above problems, the present invention proposes a new segmented and layered characterization method, which achieves accurate characterization of the residual distribution of nicotine, glycerin and propylene glycol in the pyrolysis zone of cigarettes through the design of a reasonable separation device and an efficient extraction and detection process. This method can not only reveal the distribution characteristics of components at different smoking stages, but also provide strong data support for optimizing cigarette design and developing harm reduction technologies, and has important scientific research and practical application value. Summary of the invention

[0005] The purpose of the present invention is to provide a method for characterizing the spatial residual distribution and release rate of nicotine, glycerol and propylene glycol in the pyrolysis zone during the puff-by-puff pyrolysis of cigarettes. By this method, the residual amount of nicotine, glycerol and propylene glycol at different positions and time points in the pyrolysis zone of cigarettes and their puff-by-puff release rate distribution can be accurately determined, thereby providing a scientific basis for analyzing the pyrolysis behavior of cigarettes, optimizing cigarette design and evaluating the harmful components of cigarettes. The method has strong experimental operability and data accuracy, and can reflect the evolution law of key components in the pyrolysis process of cigarettes.

[0006] The purpose of the present invention is achieved through the following technical solutions

[0007] The present invention designs a method for characterizing the spatial residual distribution and release rate of nicotine, glycerin and propylene glycol in the pyrolysis zone of a cigarette during the puff-by-puff pyrolysis process by targeting cigarettes that are continuously pyrolyzed and puff-by-puff airflow smoked. The method first spatially segments and layers the pyrolysis zone of the cigarette after each puff, and uses an accurate analysis method to determine the residual nicotine, glycerin and propylene glycol content in each pyrolysis zone unit. Then, through data interpolation processing, a residual distribution map in the entire pyrolysis zone of the cigarette is obtained. Next, the puff-by-puff residual distribution after different puff times is measured in turn, and the puff-by-puff release rate distribution map of nicotine, glycerin and propylene glycol at different puff stages is finally obtained by calculating the puff-by-puff release rate. Through this process, the present invention can provide the spatial distribution and release law of each component in the pyrolysis process of the cigarette, and provide new data support for tobacco science research.

[0008] The method comprises the following steps

[0009] 1) Smoking of cigarettes: The cigarettes are placed in a heating device, and the cigarette core is continuously heated by a heating program and a heating element. During the heating process, the pyrolysis zone of the cigarette is eluted by a specific suction airflow to carry out tobacco release components. The suction airflow modes that can be used during the heating process include the ISO suction mode and the HCI Canadian deep suction mode. The HCI Canadian deep suction mode is preferred, that is, the suction volume per puff is 55 mL (bell-shaped curve), the duration of each puff is 2 s, and the puff is taken every 30 s.

[0010] 2) Separation of cigarette pyrolysis zone: After each puff, the cigarette pyrolysis zone is spatially segmented and layered by the core space segmentation device to obtain pyrolysis zone units with specific pyrolysis times at different axial and radial positions. First, the cigarette core is cut into three equal parts along the axial direction for spatial stratification. Then, each core segment is coaxially layered by the core space segmentation device. Each core segment is divided into an inner layer, a middle layer and an outer layer, and the entire pyrolysis zone is finally divided into 9 different regions, including front inner, middle inner, rear inner, front middle, middle middle, rear middle, front outer, middle outer and rear outer. Through such spatial segmentation and layering, the component distribution at different positions in the pyrolysis zone can be accurately obtained. The segmentation device includes two sleeves and two stainless steel tubes with different diameters, wherein the stainless steel tubes have diameters of 3mm and 5mm, respectively, a wall thickness of 0.1mm and a length of 30mm. During layering, the inner layer, middle layer and outer layer of the core material are obtained by inserting 3mm and 5mm stainless steel tubes in sequence. The function of the sleeve is to fix the cigarette to facilitate the insertion of the stainless steel tube.

[0011] 3) Determination of ingredients: The tobacco core material after each spatial segmentation will be collected and placed in a 15mL centrifuge tube, and an appropriate amount of solvent (such as methanol) and an internal standard solution (a mixed solution of 1,3-butanediol and 2-methylquinoline) will be added. Then ball milling is performed to fully extract the nicotine, glycerol and propylene glycol in the tobacco core material. Then centrifugation is performed, the upper layer solution is extracted for organic membrane filtration, and finally the filtrate is sent to the GC-MS analysis system for quantitative component analysis. The GC-MS method is used to accurately determine the nicotine, glycerol and propylene glycol content in each pyrolysis zone unit.

[0012] 4) Data interpolation and spatial distribution construction: Based on the concentration data and spatial position of nicotine, glycerin and propylene glycol in each pyrolysis zone unit, interpolation processing is performed using data processing software such as MATLAB. Through the interpolation method, the test data under different puff times are supplemented to construct the spatial distribution map of nicotine, glycerin and propylene glycol in the entire pyrolysis zone of the cigarette. Through this data processing, the distribution law of the components in the pyrolysis zone can be obtained, and basic data can be provided for the subsequent calculation of the puff-by-puff release rate.

[0013] 5) Calculation and analysis of puff-by-puff release rate: After data processing is completed, the puff-by-puff residual distribution map can be obtained by calculating the residual amount of each component in the pyrolysis zone after different numbers of puffs. The calculation of the puff-by-puff release rate is carried out by analyzing the changes in the components in the pyrolysis zone after each puff. The specific method is based on the measured puff-by-puff residual amount and puff-by-puff release amount, and the puff-by-puff release rates of nicotine, glycerin and propylene glycol at different puff stages are calculated through numerical processing. Finally, a puff-by-puff release rate distribution map is generated, and the pyrolysis process of the cigarette is analyzed in combination with the spatial distribution data. The calculation formula for the nicotine, glycerin and propylene glycol release rates of each pyrolysis unit is:

[0014]

[0015] 6) Analysis of pyrolysis behavior characteristics at different puff stages: The puff-by-puff residual distribution diagram and puff-by-puff release rate diagram obtained by the present invention can analyze the pyrolysis behavior characteristics of cigarettes at different puff stages. For example, at different puff stages, the release patterns of nicotine, glycerin, and propylene glycol may change, which is closely related to the changes in pyrolysis temperature, time, and puff airflow. With these data, researchers can further optimize the formulation and design of cigarettes.

[0016] The specific operation process of the present invention is as follows: First, the cigarette is placed in a heating device, and the cigarette core is continuously heated by a set heating program and a heating element, and the cigarette pyrolysis zone is eluted by a specific suction airflow to carry out tobacco release components. After each puff, the cigarette pyrolysis zone is spatially segmented and layered using a cigarette core space separation device to ensure that the pyrolysis zone units at different positions can be effectively separated and calibrated. This process is performed by cutting the cigarette core into three equal parts along the axial direction, and using a stainless steel tube to coaxially layer the cut cigarette core segments to obtain nine parts, namely, front inner, middle inner, rear inner, front middle, middle middle, rear middle, front outer, middle outer, and rear outer. Then, each pyrolysis zone unit is weighed separately, and the nicotine, glycerin and propylene glycol therein are extracted using a solvent. The extract is analyzed by the GC-MS method to obtain the content of nicotine, glycerin and propylene glycol in each unit. Subsequently, according to the location of different pyrolysis zone units and the contents of nicotine, glycerin, and propylene glycol, the distribution of components in the entire pyrolysis zone was obtained through data interpolation processing. Finally, the puff-by-puff residual distribution of nicotine, glycerin, and propylene glycol in the pyrolysis zone was measured in turn after different puff times, and the puff-by-puff release rate distribution was obtained by calculation, providing a scientific basis for in-depth analysis of the changes in components during the pyrolysis process of cigarettes.

[0017] The advantages of the present invention are that, firstly, through precise spatial segmentation and stratification methods, the puff-by-puff residual distribution and puff-by-puff release rate distribution of nicotine, glycerol and propylene glycol in the pyrolysis zone of cigarettes can be carefully characterized, filling the gaps in spatial distribution and puff-by-puff analysis of traditional methods. Secondly, the use of GC-MS analysis technology, combined with data interpolation processing, ensures high-precision quantitative component analysis and spatial distribution reconstruction, and improves the reliability and repeatability of experimental results. In addition, the present invention can provide comprehensive pyrolysis behavior data at different smoking stages, helping researchers to deeply understand the changes in key components during the pyrolysis process of cigarettes, and provide a scientific basis for cigarette design optimization and harmful component control. The method is simple to operate and has efficient data processing. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 .Schematic diagram of the structure of the axial layering device in the present invention.

[0019] Figure 2 . Schematic diagram of the 9 pyrolysis units into which the cigarette is divided after smoking in the present invention.

[0020] Figure 3 . Changes in the total residual content of nicotine, glycerin and propylene glycol in the cigarette core material in the present invention.

[0021] Figure 4 .The puff-by-puff residual distribution of nicotine in the present invention.

[0022] Figure 5 . In the present invention, the residual distribution of glycerol is carried out on a mouthful-by-mouth basis.

[0023] Figure 6 . In the present invention, the propylene glycol is distributed in each mouthful.

[0024] Figure 7 . Nicotine puff-by-puff release rate distribution in the present invention.

[0025] Figure 8 . The mouthful release rate distribution of glycerol in the present invention.

[0026] Fig. 9 .The puff-by-puff release rate distribution of propylene glycol in the present invention. DETAILED DESCRIPTION

[0027] The present invention is further described below in conjunction with the accompanying drawings (embodiments):

[0028] 1) Smoking of cigarettes: Place the cigarette in a heating device, and continuously heat the cigarette core through a heating program and a heating element. During the heating process, a specific suction airflow is used to elute the pyrolysis zone of the cigarette to carry out tobacco release components. The HCI Canadian deep smoking mode is used during the heating process.

[0029] 2) Separation of cigarette pyrolysis zones: Figure 1-2 As shown, after each puff, the cigarette pyrolysis zone is spatially segmented and layered by the core space division device to obtain pyrolysis zone units with specific pyrolysis times at different axial and radial positions. The cigarette core is precisely cut into three equal parts along the axial direction, and then each section of the core is coaxially layered using a stainless steel tube (with diameters of 3mm and 5mm, respectively) to obtain the inner, middle and outer layers of the core material, respectively. Finally, 9 pyrolysis units are obtained, namely front outer, middle outer, back outer, front middle, middle middle, back middle, front inner, middle inner and back inner;

[0030] 3) Determination of ingredients: The same pyrolysis unit core materials obtained after separation of 5 cigarettes with the same number of puffs were collected and placed in a 15 mL centrifuge tube, and 5 mL of methanol and 100 μL of a mixed internal standard solution of 0.5 mg / mL 1,3-butanediol and 0.2 mg / mL 2-methylquinoline were added; ball milling was performed for 10 minutes, centrifuged for 3 minutes, and the upper layer of extract was taken and filtered through an organic filter membrane into a chromatographic bottle for GC-MS analysis.

[0031] 4) Data interpolation and spatial distribution construction: Based on the concentration data and spatial position of nicotine, glycerin and propylene glycol in each pyrolysis zone unit, interpolation processing is performed using data processing software such as MATLAB. Through the interpolation method, the test data under different puff times are supplemented to construct the spatial distribution map of nicotine, glycerin and propylene glycol in the entire pyrolysis zone of the cigarette.

[0032] 5) Calculation and analysis of puff-by-puff release rate: After data processing is completed, the puff-by-puff residual distribution map can be obtained by calculating the residual amount of each component in the pyrolysis zone after different puff times. The calculation of the puff-by-puff release rate is performed by analyzing the changes in the components in the pyrolysis zone after each puff. The specific method is based on the measured puff-by-puff residual amount and puff-by-puff release amount, and the puff-by-puff release rate of nicotine, glycerin and propylene glycol at different puff stages is calculated through numerical processing. Finally, a puff-by-puff release rate distribution map is generated, and the cigarette pyrolysis process is analyzed in combination with the spatial distribution data.

[0033] Embodiment 1:

[0034] Characterization of the puff-by-puff distribution of nicotine, glycerin, and propylene glycol residues: A peripherally heated heat-not-burn cigarette was used, i.e., the heating element of the heat-not-burn cigarette was distributed around the periphery of the cigarette. The heat-not-burn cigarette was puffed puff by puff using the HCI smoking mode to simulate the pyrolysis behavior of the cigarette during actual use, and the number of puffs was set to 8. After the puff, the core material in the cigarette was Figure 1 The device shown divides the pyrolysis zone of the cigarette core material into 9 Figure 2The pyrolysis unit shown. Five cigarettes with the same number of puffs were separated, and the core materials of the same pyrolysis unit were collected and placed in a 15mL centrifuge tube, and 5mL of methanol and 100μL of a mixed internal standard solution of 0.5mg / mL 1,3-butanediol and 0.2mg / mL 2-methylquinoline were added; ball milling for 10 minutes, centrifugation for 3 minutes, and the upper extract was taken through an organic filter membrane to a chromatographic bottle for GC-MS analysis to obtain the residual content of the compound. Tables 1, 2 and 3 below show the residual contents of nicotine, glycerol and propylene glycol in different parts after the second, fourth and sixth puffs, respectively. Here, only the residual contents of compounds in different parts of the second, fourth and sixth puffs of the puffs 1-8 are selected for display. In the table, the original mass of the core materials of each part of the cigarette that has not been heated is used as the benchmark, and the mass of the target compound in 1g of the core material (unit mg / g) is used to represent the residual amount of glycerol, nicotine and 1,2-propylene glycol during the smoking process. It was observed that the residual contents of compounds in different parts of the tobacco core material showed regular changes under the same number of puffs. Taking nicotine as an example, the residual content in radial direction basically showed the order of inner layer > middle layer > outer layer, and the residual content in axial direction basically showed the order of front section > middle section > rear section.

[0035] Table 1 Residual contents of nicotine, glycerin and propylene glycol in 9 parts of cigarette core materials after the second puff

[0036]

[0037] Table 2 Residual contents of nicotine, glycerin and propylene glycol in 9 parts of cigarette core materials after the 4th puff

[0038]

[0039] Table 3 Residual contents of nicotine, glycerin and propylene glycol in 9 parts of cigarette core materials after the 6th puff

[0040]

[0041] Down Figure 3 The figure shows the changes in the total residual content of nicotine, glycerin and propylene glycol in the core material. The data was normalized based on the original content of each compound in the unsmoked cigarette. It can be seen from the figure that, overall, the residual amounts of the target compounds in the 9 parts of the core material that were separated are added together, and the residual amounts of the three compounds show a gradual decreasing trend with the increase in the number of puffs. The analysis shows that continuous heating and periodic puffing airflow cause the released components to be continuously taken away, thus showing an overall decrease in the residual amount of chemical components in the core material with each puff.

[0042] As the number of puffs increases, the residual amount of 1,2-propylene glycol decreases fastest. At the end of the first puff, its residual amount is 75.80% of the initial content, and at the end of the eighth puff, only 0.31% remains. At the end of the eighth puff, the residual amounts of nicotine and glycerol are 2.98% and 21.90% of the initial content, respectively. There are obvious differences in the reduction rates of the three chemical components in the core material during the smoking process. The boiling points of the three compounds are 1,2-propylene glycol < nicotine < glycerol, and the order of the boiling points corresponds to the reduction rate of their residual amounts, indicating that the boiling point of the compound affects the thermal release process of the chemical components of the core material.

[0043] According to the measured nicotine, glycerin and propylene glycol residue data, the bilinear interpolation method in MATLAB software was used to obtain the puff-by-puff residual distribution of nicotine, glycerin and propylene glycol in the cigarette core material. Figure 4-6 . The gradient from blue to red in the figure represents the gradual increase in the residual content of the compound. During the smoking process, the chemical components in the outer layer and the middle and rear areas of the core material are released first, especially in the outer layer of the middle and rear areas. As the heating and smoking process continues, the residual amounts of the three chemical components in the middle and inner layers gradually begin to decrease. At the same time, it was observed that the residual amounts of chemical components in the inner and middle layers of the core material were higher than the initial amounts in the early stages of smoking. This may be related to the temperature field distribution inside the core material during the use of heated cigarettes. The difference in temperature distribution in different parts causes the chemical components in the higher temperature areas to diffuse to the lower temperature areas, and the nicotine, glycerin and propylene glycol in the higher temperature areas are also lost more with the airflow. These factors combined lead to this phenomenon.

[0044] Embodiment 2:

[0045] Characterization of the puff-by-puff release rate distribution of nicotine, glycerin and propylene glycol: The release rates of nicotine, glycerin and propylene glycol in each pyrolysis unit are calculated according to formula (1) based on the residual content of the compounds in different pyrolysis units, and then the compound release rates of different pyrolysis units from 1 to 8 puffs are calculated in turn. The following Tables 4, 5 and 6 show the calculated compound release rates for the 2nd, 4th and 6th puffs, respectively. It is observed that the release rates in the table are less than 0, which means that the residual content of the compounds in the tobacco core material in the corresponding area increases compared to the initial content during the smoking process. The areas with release rates less than 0 are mainly concentrated in the inner and middle layers of the first few puffs. Based on the measured nicotine, glycerin and propylene glycol release rate data, the bilinear interpolation method in the MATLAB software is called to obtain the puff-by-puff release rate distribution of nicotine, glycerin and propylene glycol in the tobacco core material as shown in the figure. Figure 7-9. The gradual change from white to black in the figure indicates the gradual increase in the release rate of the compounds. For the same number of puffs, the release rate is generally outer layer > middle layer > inner layer in the radial direction, and generally rear section > middle section > front section in the axial direction, which is also closely related to the distribution of the temperature field in the core material. As the number of puffs increases, the release rates of the three compounds in the core material at different locations gradually increase, indicating that the compounds are gradually released completely as the heating continues. Among them, propylene glycol is released completely first, followed by nicotine, and finally glycerin, which is related to the boiling point of the compound.

[0046] Table 4 Release rates of nicotine, glycerin and propylene glycol in 9 parts of the core materials after the second puff

[0047]

[0048] Table 5 Release rates of nicotine, glycerin and propylene glycol in 9 parts of the core materials after the 4th puff

[0049]

[0050]

[0051] Table 6 Release rates of nicotine, glycerin and propylene glycol in 9 parts of the core materials after the sixth puff

[0052]

Claims

1. A method for characterizing the spatial residual distribution and release rate of nicotine, glycerol and propylene glycol in the pyrolysis zone during the puff-by-puff pyrolysis of cigarettes, characterized in that: The method is for cigarettes that are continuously pyrolyzed and puffed. After each puff, the pyrolysis zone of the cigarette is spatially segmented and layered, and the nicotine, glycerin and propylene glycol residual in each pyrolysis zone unit are simultaneously measured by an analytical method. The residual distribution of nicotine, glycerin and propylene glycol in the entire pyrolysis zone of the cigarette is obtained through data interpolation processing, and the puff-by-puff residual amount of different puff times is measured in turn, and the puff-by-puff release rate is calculated. The puff-by-puff release rate distribution of nicotine, glycerin and propylene glycol in the pyrolysis zone is obtained through interpolation processing.

2. The method according to claim 1, characterized in that The specific steps of this method include: (1) Smoking of cigarettes: placing cigarettes in a heating device, continuously heating the cigarette core through a heating program and a heating element, and during the heating process, a specific suction airflow is used to wash out the pyrolysis zone of the cigarette, carrying out the tobacco release components; (2) Segmentation of the pyrolysis zone of the cigarette: After each puff, the pyrolysis zone of the cigarette is spatially segmented and layered by a cigarette core space segmentation device to obtain pyrolysis zone units with specific pyrolysis times at different axial and radial positions; (3) Determination of ingredients: Each pyrolysis zone unit was weighed and solvent extracted, and the extract was analyzed by GC-MS method to determine the residual nicotine, glycerin and propylene glycol content in each pyrolysis zone unit; (4) Data interpolation and spatial distribution construction: Based on the nicotine, glycerin and propylene glycol content and their spatial position in each pyrolysis zone unit, the distribution of residual nicotine, glycerin and propylene glycol in the entire pyrolysis zone of the cigarette is obtained through data interpolation; (5) Calculation and analysis of puff-by-puff release rate: The puff-by-puff residual amount at different puff times was measured in turn, and the puff-by-puff release rate was calculated. The puff-by-puff release rate distribution of nicotine, glycerin, and propylene glycol in the pyrolysis zone was obtained by interpolation processing. The calculation formula for the nicotine, glycerin, and propylene glycol release rate of each pyrolysis unit is:

3. The method according to claim 1 or 2, characterized in that: The spatial segmentation and layering refers to first cutting the cigarette core into three equal parts along the axial direction, and then using a core space separation device to coaxially layer each cut core segment to obtain nine parts, namely front inner, middle inner, rear inner, front middle, middle middle, rear middle, front outer, middle outer, and rear outer; the dividing device includes two sleeves and two stainless steel tubes with different diameters, wherein the stainless steel tubes have diameters of 3mm and 5mm respectively, a wall thickness of 0.1mm, and a length of 30mm.

4. The method according to claim 1 or 2, characterized in that: During the layering process, 3 mm and 5 mm stainless steel tubes are inserted in sequence to obtain the inner layer, middle layer and outer layer of the tobacco core material respectively.

5. The method according to claim 1 or 2, characterized in that: The analysis method comprises: placing each portion of the cigarette core material into a 15 mL centrifuge tube, adding 5 mL of methanol and 100 μL of a mixed internal standard solution of 0.5 mg / mL 1,3-butanediol and 0.2 mg / mL 2-methylquinoline; ball milling for 10 minutes, centrifuging for 3 minutes, taking the upper layer of the extract and passing it through an organic filter membrane into a chromatographic bottle for GC-MS analysis.

6. The method according to claim 1 or 2, characterized in that: The data interpolation processing refers to the use of MATLAB software to input the puff-by-puff residual amount and puff-by-puff release rate data of samples in different parts, and output the spatial distribution and spatial release rate diagram of nicotine, glycerin and propylene glycol in the pyrolysis zone.

7. The method according to claim 6, characterized in that The resulting spatial distribution maps and spatial release rates of nicotine, glycerol, and propylene glycol were used to analyze the pyrolysis behavior characteristics at different smoking stages.

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