Fluid chip pipetting equipment and fluid chip pipetting method

Abstract

The invention provides fluid chip pipetting equipment and a fluid chip pipetting method, and relates to the technical field of biochips, the fluid chip pipetting equipment comprises a working platform, a moving part, a pipetting device and a drying device, the working platform comprises a fluid chip placing area, the moving part can move above the working platform, the pipetting device is arranged above the working platform, and the drying device is arranged above the fluid chip placing area. The pipetting device is arranged on the moving part and used for injecting and / or absorbing liquid into the fluid chip, and the drying device is used for injecting gas into a flow channel of the fluid chip. The drying device is additionally arranged, circulation of gas in the fluid chip is accelerated, the drying efficiency of the fluid chip is improved, the drying time is greatly shortened, liquid is prevented from remaining in a flow channel of the fluid chip, in addition, liquid relief operation is carried out by driving the liquid relief device through the moving part, liquid relief operation does not need to be manually carried out through a liquid relief gun, and the labor intensity of workers is reduced. And operators are prevented from being in contact with chemicals, the automation degree is high, and higher safety is achieved.

Description

Fluid chip pipetting device and fluid chip pipetting method Technical Field

[0001] The present invention relates to the technical field of biochips, and in particular to a fluid chip pipetting device and a fluid chip pipetting method. Background Art

[0002] Microfluidics technology has important applications in sequencing, and fluidic chips are the primary platform for implementing this technology. However, due to their small flow channels and complex structures, liquid residue can easily remain during liquid exchange, compromising reagent replacement. Current pipetting equipment is relatively simple, with only a filling function. Drying typically involves evaporation while standing still, resulting in poor drying performance.

[0003] Summary of the Invention

[0004] The technical problem to be solved by the present invention is to overcome the defects of liquid residue and poor drying effect in the fluid chip in the prior art, and to provide a fluid chip pipetting device and a fluid chip pipetting method.

[0005] The present invention solves the above technical problems through the following technical solutions:

[0006] A fluid chip pipetting device, comprising:

[0007] A working platform, comprising a fluid chip placement area;

[0008] A moving component capable of moving above the working platform;

[0009] a pipetting device, the pipetting device being provided on the moving component and being used for injecting and / or aspirating liquid into the fluid chip;

[0010] A drying device is used to inject gas into the flow channel of the fluid chip.

[0011] In this solution, by adding a drying device, the circulation of gas inside the fluid chip is accelerated, the drying efficiency of the fluid chip is improved, the drying time is greatly shortened, and the residue of liquid in the flow channel of the fluid chip is avoided. In addition, the pipetting operation is performed by driving the pipetting device through moving parts. The pipetting does not require manual operation using a pipette gun, which avoids the contact between the operator and chemicals. It has a high degree of automation and is safer.

[0012] Preferably, the moving component includes a first robotic arm, the first robotic arm has at least three degrees of freedom and can move along three directions of X, Y, and Z, and the pipetting device is arranged on the first robotic arm.

[0013] In this solution, the first robotic arm has a high degree of freedom and is more flexible.

[0014] Preferably, the work platform further includes a tip consumables area, a reagent storage area and a tip recovery area, and the first robotic arm is capable of moving between the tip consumables area, the reagent storage area, the tip recovery area and the fluid chip placement area.

[0015] In this solution, the first robotic arm moves in the Z direction, driving the pipette to remove tips, aspirate liquid, inject liquid, and remove tips. Movement in the X and Y directions also enables the pipette to move between the tip consumables area, reagent storage area, tip recovery area, and fluid chip placement area. Furthermore, the provision of a tip consumables area allows the pipette to be used with disposable tips, effectively preventing cross-contamination.

[0016] Preferably, the moving component includes a second robotic arm, the second robotic arm has at least three degrees of freedom and can move in three directions of X, Y and Z. The second robotic arm can move in the fluid chip placement area, and the drying device is arranged on the second robotic arm.

[0017] In this solution, driven by the second robotic arm, the drying device can move in the fluid chip placement area, thereby drying each fluid chip with higher drying efficiency.

[0018] Preferably, the moving component is a robotic arm having at least three degrees of freedom and capable of moving in three directions, namely, X, Y, and Z. The pipetting device and the drying device are arranged on the robotic arm.

[0019] In this solution, by arranging the pipetting device and the drying device on one robotic arm, it is helpful to reduce costs, and the pipetting device and the drying device will not interfere with each other during the movement process, and the two can work simultaneously.

[0020] Preferably, the drying device includes an air path device, and the air path device is arranged on the moving component.

[0021] In this solution, an air path device is used for drying, which is beneficial to improving the drying efficiency and will not affect the biochemical reaction characteristics inside the fluid chip. The air path device can move with the moving parts, and thus the fluid chip can be dried in a targeted manner with higher efficiency.

[0022] Preferably, the air path device includes an air pump, an air outlet pipe and a nozzle, one end of the air outlet pipe is connected to the air outlet of the air pump, and the other end of the air outlet pipe is connected to the nozzle.

[0023] In this solution, the air pump can generate air pressure, which can increase the air flow velocity at the nozzle, thereby improving the drying efficiency of the flow channel in the fluid chip.

[0024] Preferably, the nozzle is an air blowing suction cup.

[0025] In this solution, an air blowing suction cup is used. On the one hand, the air blowing suction cup can fit more closely with the flow channel inlet of the fluid chip, and the connection reliability is high. On the other hand, the air blowing suction cup can be replaced with air outlets of different sizes, and its application range is wider. The air outlet area is adjustable and can adapt to flow channels of different apertures.

[0026] Preferably, the air path device further includes an air intake pipe and a filter, one end of the air intake pipe is connected to the air inlet of the air pump, and the other end of the air intake pipe is connected to the filter.

[0027] In this solution, by adding a filter, the cleanliness of the air entering the flow channel of the fluid chip is ensured, thereby preventing contamination of the fluid chip.

[0028] Preferably, the air path device further includes a flow mechanism, and the flow mechanism is arranged on the air outlet pipe.

[0029] In this solution, the flow mechanism can detect the working status in real time and adjust different flow rates according to demand.

[0030] Preferably, the fluid chip placement area is provided with a fluid chip placement platform and a fixing portion, the fluid chip placement platform is detachably arranged in the fixing portion, and a plurality of fluid chips are arranged on the fluid chip placement platform.

[0031] In this solution, the fluid chip placement platform is more stably placed and less likely to shift, and the fluid chip placement platform can be replaced to adapt to fluid chips of different structures.

[0032] Preferably, the fluid chip pipetting device is used for sequencing.

[0033] In this solution, liquid residue is less likely to remain inside the flow of the fluid chip, sequencing is less affected by interference factors, and the sequencing results are more accurate.

[0034] A fluid chip pipetting method, which uses the fluid chip pipetting device as described above, the pipetting method comprising:

[0035] The moving component drives the pipetting device to inject liquid into the fluid chip;

[0036] The moving component drives the pipetting device to aspirate liquid from the fluid chip;

[0037] The drying device blows air to dry the fluid chip.

[0038] The present method does not require manual pipetting, thus avoiding contact between operators and chemicals. The method has a high degree of automation and can accelerate the drying efficiency of the flow channel of the fluid chip through the drying device, thus avoiding the generation of liquid residue.

[0039] Preferably, the step of the moving component driving the pipetting device to inject liquid into the fluid chip specifically includes the following steps:

[0040] S11, the moving component drives the pipetting device to move to the pipette tip consumables area, and drives the pipetting device to descend to obtain the pipette tip;

[0041] S12, the moving component drives the pipetting device to move to the reagent storage area, and the pipetting device absorbs the reagent;

[0042] S13, the moving component drives the pipetting device to move to the fluid chip placement area, and the pipetting device injects liquid into the fluid chip;

[0043] S14, the moving component drives the pipetting device to move to the tip recovery area, and the pipetting device discards the tip.

[0044] Preferably, the step of the moving component driving the pipetting device to aspirate the fluid chip specifically includes the following steps:

[0045] S21, the moving component drives the pipetting device to move to the tip consumables area, and the pipetting device descends to obtain the tip;

[0046] S22, the moving component drives the pipetting device to move to the fluid chip placement area, and the pipetting device aspirates the fluid chip;

[0047] S23, the moving component drives the pipetting device to move to the tip recovery area, and the pipetting device discharges the waste liquid and discards the tip.

[0048] Preferably, the step of the drying device blowing air to dry the fluid chip specifically includes the following steps:

[0049] S31, the moving component drives the drying device to move above the chip port of the fluid chip;

[0050] S32, the moving device drives the drying device to move downward, so that the air outlet of the drying device is in contact with the chip port;

[0051] S33, the drying device blows air to dry the fluid chip;

[0052] S34. Repeat steps S31 to S33 until the drying device completes the air drying of all fluid chips. The positive effects of the present invention are: in the present invention, by adding a drying device, the circulation of air inside the fluid chip is accelerated, the drying efficiency of the fluid chip is improved, the drying time is greatly shortened, and liquid residue in the flow channel of the fluid chip is avoided. In addition, the pipetting operation is performed by driving the pipetting device with a moving part. The pipetting does not require manual operation using a pipette gun, avoiding contact between the operator and chemicals, and has a high degree of automation and is safer. BRIEF DESCRIPTION OF THE DRAWINGS

[0053] FIG1 is a schematic structural diagram of a fluid chip pipetting device according to a preferred embodiment of the present invention;

[0054] FIG2 is a schematic structural diagram of an air path device according to a preferred embodiment of the present invention;

[0055] FIG3 is a flow chart of a pipetting method according to a preferred embodiment of the present invention.

[0056] Work Platform 100

[0057] Fluid chip placement area 110

[0058] Fixing portion 111

[0059] Fluid chip placement platform 112

[0060] Tip consumables area 120

[0061] Reagent storage area 130

[0062] Tip recovery area 140

[0063] Fluid Chip 200

[0064] First robotic arm 310

[0065] Second robotic arm 320

[0066] Liquid handling device 400

[0067] Gas path device 500

[0068] Air Pump 510

[0069] Exhaust pipe 520

[0070] Flow mechanism 530

[0071] Air suction cup 540

[0072] Intake pipe 550

[0073] Filter 560 DETAILED DESCRIPTION

[0074] A preferred embodiment is given below and the present invention is described more clearly and completely in conjunction with the accompanying drawings.

[0075] As shown in Figures 1 and 2, this embodiment provides a fluid chip pipetting device, which includes: a working platform 100, a moving part, a pipetting device 400 and a drying device. The working platform 100 includes a fluid chip placement area 110, the moving part can move above the working platform 100, the pipetting device 400 is arranged on the moving part, and is used to inject and / or absorb liquid into the fluid chip 200, and the drying device is used to inject gas into the flow channel of the fluid chip 200.

[0076] By adding a drying device, the circulation of gas inside the fluid chip 200 is accelerated, the drying efficiency of the fluid chip 200 is improved, the drying time is greatly shortened, and the residue of liquid in the flow channel of the fluid chip 200 is avoided. In addition, the pipetting operation is performed by driving the pipetting device 400 through a moving part. The pipetting does not require manual operation using a pipette gun, which avoids the contact between the operator and chemicals. It has a high degree of automation and is safer.

[0077] In this embodiment, both the pipetting and the air-blowing drying are directed toward the chip port of the fluid chip 200 .

[0078] Specifically, the fluid chip 200 includes a chip inlet and a chip outlet. During injection, the pipetting device 400 must be aligned with the chip inlet. During aspiration, the pipetting device 400 can be aligned with either the chip inlet or the chip outlet. During gas drying, the drying device can be aligned with either the chip inlet or the chip outlet.

[0079] Here, clean air or inert gas can be used for drying.

[0080] Among them, in this embodiment, the pipetting device 400 adopts an ADP air plunger pipetting pump, whose pipetting range is 1μL-1000μL and the pipetting accuracy can reach up to ±1%. The pipetting pump integrates a pressure sensor, which can effectively detect reagent blockage and flow channel blockage problems of the fluid chip 200.

[0081] In other embodiments, the liquid transfer device may also be a syringe, a micropump, or other devices with injection and / or aspiration functions.

[0082] In other embodiments, multiple pipetting devices can be provided, and providing multiple pipetting devices simultaneously to form a multi-channel layout is beneficial to improving pipetting efficiency, such as providing an 8-channel adjustable pipetting device.

[0083] In other embodiments, multiple drying devices may be provided. Arranging multiple drying devices simultaneously to form a multi-channel layout can improve drying efficiency. As shown in FIG1 , in this embodiment, the movable component includes a first robotic arm 310. The first robotic arm 310 has three degrees of freedom and can move in the X, Y, and Z directions. The pipetting device 400 is disposed on the first robotic arm 310. The first robotic arm 310 has a high degree of freedom and is more flexible. Of course, in other embodiments, the first robotic arm 310 may have more than three degrees of freedom.

[0084] The work platform 100 further includes a pipette tip consumables area 120, a reagent storage area 130, and a pipette tip recovery area 140. The first robotic arm 310 is capable of moving between the pipette tip consumables area 120, the reagent storage area 130, the pipette tip recovery area 140, and the fluid chip placement area 110. The first robotic arm 310 reciprocates in the Z direction, driving the pipette device 400 to remove pipette tips, aspirate liquid, inject liquid, and remove pipette tips. The first robotic arm 310 moves along the X and Y directions to drive the pipette device 400 to move between the pipette tip consumables area 120, the reagent storage area 130, the pipette tip recovery area 140, and the fluid chip placement area 110. In addition, by providing the pipette tip consumables area 120, the pipette device 400 can be used with disposable pipette tips, effectively avoiding cross contamination.

[0085] The reagent storage area 130 can be flexibly configured to accommodate centrifuge tubes of various sizes, ranging from 500μL to 50mL. The tip consumables area 120 can accommodate three different sizes of tips to meet pipetting needs of varying volume ranges. The tip recovery area 140 can be used to store waste bins, allowing for easy removal and disposal when the bin is full.

[0086] In this embodiment, the moving component may further include a second robotic arm 320 having three degrees of freedom, capable of movement in the X, Y, and Z directions. The second robotic arm 320 is capable of movement within the fluid chip placement area 110, and the drying device is disposed on the second robotic arm 320. Driven by the second robotic arm 320, the drying device can move within the fluid chip placement area 110, thereby drying each fluid chip 200. By moving in the Z direction, the drying device can align with the chip inlet or chip outlet of the fluid chip 200, resulting in higher drying efficiency. Of course, in other embodiments, the second robotic arm 320 may have more than three degrees of freedom.

[0087] As shown in Figure 1, in this embodiment, a first track is provided along the X direction, and the first and second robotic arms 310 and 320 have the same structure. The first robotic arm 310 includes a support body, an X-direction moving component, a Y-direction moving component, and a Z-direction moving component. The support body is provided with an X-direction moving component that cooperates with the first track and can drive the support body to move in the X direction. The support body is provided with a second track along the Y direction, and the Y-direction moving component is provided on the second track and can move in the Y direction. The Y-direction moving component is provided with a third track along the Z direction, and the Z-direction moving component is provided on the third track and can move in the Z direction. The pipetting device is connected to the Z-direction moving component.

[0088] In other embodiments, the drying device and the pipetting device may be replaced with a clamping device, a capping device, a code scanning device, or the like to achieve corresponding functions. Alternatively, a clamping device, a capping device, a code scanning device, or the like may be added to the pipetting device to achieve more functions.

[0089] In addition, modules such as mixing, shaking, and magnetic rack can be added to the working platform 100 .

[0090] In other embodiments, the layout of various areas on the work platform can be changed to meet corresponding needs.

[0091] In other embodiments, the fluid chip pipetting device can also be used in the field of reagent packaging.

[0092] In other embodiments, the movable component may be a single robotic arm having three degrees of freedom, capable of moving in the X, Y, and Z directions, with the pipetting device and drying device disposed on the robotic arm. By disposing the pipetting device 400 and drying device on a single robotic arm, costs can be reduced, and the pipetting device 400 and drying device do not interfere with each other during movement, allowing them to operate simultaneously. The robotic arm may also have more than three degrees of freedom.

[0093] In this embodiment, the drying device includes an air path device 500, which is mounted on a movable component. Using the air path device 500 for drying improves drying efficiency without affecting the biochemical reaction characteristics within the fluid chip 200. The air path device 500 can move with the movable component, allowing for targeted drying of the fluid chip 200, resulting in higher efficiency.

[0094] In other embodiments, the drying device may not be provided with the air path device 500 and may perform drying by using a fan.

[0095] In this embodiment, as shown in Figure 2, the air path device 500 includes an air pump 510, an air outlet pipe 520, and a nozzle. One end of the air outlet pipe 520 is connected to the air outlet of the air pump 510, and the other end of the air outlet pipe 520 is connected to the nozzle. The air pump 510 can generate air pressure, which can increase the air flow velocity at the nozzle, thereby improving the drying efficiency of the flow channel in the fluid chip 200.

[0096] In other embodiments, the air path device 500 may not be disposed on a moving component, and drying may be performed by changing the jet angle of the nozzle.

[0097] Specifically, in this embodiment, the nozzle is an air blowing suction cup 540. Using the air blowing suction cup 540, on the one hand, allows the air blowing suction cup 540 to fit more closely with the flow channel inlet of the fluid chip 200, improving connection reliability. On the other hand, the air blowing suction cup 540 can be replaced with air outlets of different sizes, thus having a wider range of applications and an adjustable air outlet area, adapting to flow channels of different apertures.

[0098] In this embodiment, the air path device 500 further includes an air inlet pipe 550 and a filter 560. One end of the air inlet pipe 550 is connected to the air inlet of the air pump 510, and the other end of the air inlet pipe 550 is connected to the filter 560. The addition of the filter 560 ensures the cleanliness of the air entering the flow channel of the fluid chip 200, preventing contamination of the fluid chip 200.

[0099] In other embodiments, when the cleanliness of the ambient air is relatively high, the air intake pipe and the filter may not be provided.

[0100] In this embodiment, the gas path device 500 further includes a flow mechanism 530, which is disposed on the gas outlet pipe 520. The flow mechanism 530 can detect the working status in real time and adjust different flow rates according to demand.

[0101] Specifically, the flow mechanism may be a flow meter or other components with flow monitoring and regulation functions.

[0102] As shown in Figure 1, in this embodiment, the fluid chip placement area 110 is provided with a fluid chip placement platform 112 and a fixing portion 111. The fluid chip placement platform 112 is detachably mounted within the fixing portion 111, and a plurality of fluid chips 200 are mounted on the fluid chip placement platform 112. The placement of the fluid chip placement platform 112 is more stable and less prone to displacement. Moreover, the fluid chip placement platform 112 is replaceable, thereby adapting to fluid chips 200 of different structures and sizes.

[0103] In this embodiment, the fluid chip pipetting device is used for sequencing, more specifically, single molecule sequencing. Since liquid residue is less likely to remain in the flow channel of the fluid chip 200, single molecule sequencing is less susceptible to interference factors and the sequencing results are more accurate.

[0104] In this embodiment, the fluid chip 200 pipetting device also includes a control system, which includes a host computer, connecting lines and a driver. Through the electrical connection between the host computer and the driver, and through communication between the host computer and the driver, the valves of the first robotic arm 310, the second robotic arm 320 and the air pump 510 can be controlled separately, or they can be jointly controlled through autonomous timing to reduce manual participation. The number of control channels can be freely selected, and the number of operations and the cycle mode can be defined by the host computer to achieve fully automated control means.

[0105] The host computer issues logical instructions through high-speed data lines, communicating with the driver. Handshake signal verification and data verification ensure the correctness of the instructions, allowing the driver to control the corresponding components to achieve automatic liquid aspiration, automatic injection, and automatic air blowing, ensuring the accuracy of the entire process without human intervention. Each component is electronically controlled and can be operated quickly and conveniently with a single button on the host computer. The injection time, speed, and volume can be precisely controlled, resulting in high stability and effective avoidance of human error.

[0106] In addition, as shown in FIG3 , this embodiment further provides a fluid chip pipetting method, which uses the fluid chip pipetting device as described above. The pipetting method includes:

[0107] S10, the moving component drives the pipetting device to inject liquid into the fluid chip.

[0108] S20: The moving component drives the pipetting device to aspirate liquid from the fluid chip.

[0109] S30, the drying device blows air to dry the fluid chip.

[0110] The present method does not require manual pipetting, thus avoiding contact between operators and chemicals. The method has a high degree of automation and can accelerate the drying efficiency of the flow channel of the fluid chip through the drying device, thus avoiding the generation of liquid residue.

[0111] In other embodiments, before using the fluid chip for reaction, step S30 can be performed first to remove dust in the flow channel and keep the flow channel dry. If there is residual liquid in the fluid chip, step S20 can be performed first to suck out the residual liquid.

[0112] In other embodiments, step S20 and step S30 may also be performed simultaneously. When cleaning the fluid chip, the drying efficiency can be improved by simultaneously draining the waste liquid in the flow channel in step S20 and performing air drying.

[0113] In this embodiment, S10 specifically includes:

[0114] S11. The moving component drives the pipetting device to move to the tip consumables area, and drives the pipetting device to descend to obtain the tip.

[0115] S12. The moving component drives the pipetting device to move to the reagent storage area, and the pipetting device absorbs the reagent.

[0116] S13. The moving component drives the pipetting device to move to the fluid chip placement area, and the pipetting device injects liquid into the fluid chip.

[0117] S14. The moving component drives the pipetting device to move to the tip recovery area, and the pipetting device discards the tip.

[0118] In this embodiment, S20 specifically includes:

[0119] S21. The moving component drives the pipetting device to move to the tip consumables area, and the pipetting device descends to obtain the tip.

[0120] S22. The moving component drives the pipetting device to move to the fluid chip placement area, and the pipetting device aspirates liquid from the fluid chip.

[0121] S23. The moving component drives the pipetting device to move to the tip recovery area, and the pipetting device discharges the waste liquid and discards the tip.

[0122] In this embodiment, S30 specifically includes:

[0123] S31, the moving component drives the drying device to move above the chip port of the fluid chip;

[0124] S32, the moving device drives the drying device to move downward so that the air outlet of the drying device is in contact with the chip opening;

[0125] S33, the drying device blows air to dry the fluid chip;

[0126] S34. Repeat steps S31 to S33 until the drying device completes the air-blowing drying of all fluid chips.

[0127] Although specific embodiments of the present invention have been described above, those skilled in the art will appreciate that these are merely illustrative and that the scope of the present invention is defined by the appended claims. Those skilled in the art may make various changes or modifications to these embodiments without departing from the principles and essence of the present invention, and such changes and modifications are intended to fall within the scope of the present invention.

Claims

1. A fluid chip pipetting device, characterized in that: These include: A working platform, comprising a fluid chip placement area; A moving component capable of moving above the working platform; a pipetting device, the pipetting device being provided on the moving component and being used for injecting and / or aspirating liquid into the fluid chip; A drying device is used to inject gas into the flow channel of the fluid chip.

2. The fluid chip pipetting device according to claim 1, wherein: The moving component includes a first robotic arm. The first robotic arm has at least three degrees of freedom and can move along three directions of X, Y, and Z. The pipetting device is arranged on the first robotic arm.

3. The fluid chip pipetting device according to claim 2, characterized in that: The work platform further includes a pipette tip consumables area, a reagent storage area, and a pipette tip recovery area, and the first robotic arm is capable of moving between the pipette tip consumables area, the reagent storage area, the pipette tip recovery area, and the fluid chip placement area.

4. The fluid chip pipetting device according to at least one of claims 1 to 3, characterized in that The moving component includes a second robotic arm, which has at least three degrees of freedom and can move along three directions of X, Y, and Z. The second robotic arm can move in the fluid chip placement area, and the drying device is arranged on the second robotic arm.

5. The fluid chip pipetting device according to at least one of claims 1 to 3, characterized in that The moving component is a robotic arm, which has at least three degrees of freedom and can move along three directions of X, Y, and Z. The pipetting device and the drying device are arranged on the robotic arm.

6. The fluid chip pipetting device according to at least one of claims 1 to 5, characterized in that The drying device includes an air path device, and the air path device is arranged on the moving component.

7. The fluid chip pipetting device according to claim 6, characterized in that: The air path device includes an air pump, an air outlet pipe and a nozzle. One end of the air outlet pipe is connected to the air outlet of the air pump, and the other end of the air outlet pipe is connected to the nozzle.

8. The fluid chip pipetting device according to claim 7, wherein: The nozzle is an air blowing suction cup.

9. The fluid chip pipetting device according to claim 8, characterized in that: The air path device further includes an air intake pipe and a filter. One end of the air intake pipe is connected to the air inlet of the air pump, and the other end of the air intake pipe is connected to the filter.

10. The fluid chip pipetting device according to claim 9, characterized in that: The air path device further includes a flow mechanism, which is arranged on the air outlet pipe.

11. The fluid chip pipetting device according to at least one of claims 1 to 10, characterized in that The fluid chip placement area is provided with a fluid chip placement platform and a fixing portion. The fluid chip placement platform is detachably arranged in the fixing portion. A plurality of fluid chips are arranged on the fluid chip placement platform.

12. The fluid chip pipetting device according to at least one of claims 1 to 11, characterized in that The fluid chip pipetting device is used for sequencing.

13. A method for pipetting liquid on a fluid chip, characterized in that: It uses the fluid chip pipetting device according to any one of claims 1 to 11, and the pipetting method includes: The moving component drives the pipetting device to inject liquid into the fluid chip; The moving component drives the pipetting device to aspirate liquid from the fluid chip; The drying device blows air to dry the fluid chip.

14. The method for pipetting a fluid chip according to claim 13, wherein: The step of the moving component driving the pipetting device to inject liquid into the fluid chip specifically includes the following steps: S11, the moving component drives the pipetting device to move to the pipette tip consumables area, and drives the pipetting device to descend to obtain the pipette tip; S12, the moving component drives the pipetting device to move to the reagent storage area, and the pipetting device absorbs the reagent; S13, the moving component drives the pipetting device to move to the fluid chip placement area, and the pipetting device injects liquid into the fluid chip; S14, the moving component drives the pipetting device to move to the tip recovery area, and the pipetting device discards the tip.

15. The method for pipetting a fluid chip according to claim 13 or 14, wherein: The step of the moving component driving the pipetting device to aspirate the fluid chip specifically includes the following steps: S21, the moving component drives the pipetting device to move to the tip consumables area, and the pipetting device descends to obtain the tip; S22, the moving component drives the pipetting device to move to the fluid chip placement area, and the pipetting device aspirates the fluid chip; S23, the moving component drives the pipetting device to move to the tip recovery area, and the pipetting device discharges the waste liquid and discards the tip.

16. The method for pipetting a fluid chip according to at least one of claims 13 to 15, characterized in that: The step of the drying device blowing air to dry the fluid chip specifically includes the following steps: S31, the moving component drives the drying device to move above the chip port of the fluid chip; S32, the moving device drives the drying device to move downward, so that the air outlet of the drying device is in contact with the chip port; S33, the drying device blows air to dry the fluid chip; S34. Repeat steps S31 to S33 until the drying device completes the air-blowing drying of all fluid chips.

Images