Uric acid reducing dietary fiber electuary and preparation method thereof

Abstract

The invention belongs to the field of functional foods, and particularly relates to dietary fiber granules with an effect of reducing uric acid and a preparation method of the dietary fiber granules. The dietary fiber electuary for reducing uric acid consists of the following components in parts by mass: 50-90 parts of inulin, 5-20 parts of fructo-oligosaccharide and 5-20 parts of citrus fiber. The invention also provides a preparation method of the uric acid reducing dietary fiber electuary. The inulin, the fructo-oligosaccharide and the citrus fiber are matched for use, the synergistic effect is remarkable, the uric acid metabolism capacity of intestinal bacteria can be improved, and uric acid discharge is facilitated; meanwhile, the inulin and the fructo-oligosaccharide can relieve inflammation and further play a role in promoting reduction of the uric acid level, and the composition takes effect quickly and is remarkable in uric acid reduction effect.

Description

Technical Field

[0001] The invention belongs to the field of functional foods, and in particular relates to a dietary fiber granule with uric acid-lowering effect and a preparation method thereof. Background Art

[0002] In recent years, with the changes in lifestyle and dietary structure, the prevalence of hyperuricemia has increased year by year, and has shown a clear trend of younger people. It has become the second largest metabolic disease after diabetes. A large number of clinical surveys have shown that hyperuricemia can not only develop into gout, but is often accompanied by other complications. It is an independent risk factor for other diseases such as hypertension, hyperlipidemia, type 2 diabetes, metabolic syndrome, chronic kidney disease, etc., and is a serious threat to human health. In terms of clinical drug treatment, although existing drugs such as allopurinol, febuxostat or benzbromarone can inhibit the production of uric acid or promote its excretion, these drugs have obvious side effects. For example, long-term use may cause serious liver and kidney damage and cardiovascular disease risks.

[0003] Hyperuricemia and gout are metabolic syndromes caused by purine metabolism disorders. Uric acid is the final product of purine metabolism in the human body, and the uric acid level in the blood is regulated by the balance of uric acid formation and excretion. Therefore, when uric acid is overproduced, uric acid excreted insufficiently, or both exist at the same time, the blood uric acid level will increase. In healthy individuals, nearly two-thirds of uric acid is excreted through the kidneys, and the remaining one-third is excreted through the intestines. In individuals with high uric acid levels, nearly 70% of uric acid is excreted through the intestines. Therefore, the intestine is one of the important organs for excreting uric acid.

[0004] Under normal circumstances, circulating uric acid is transported to intestinal epithelial cells and then secreted into the intestinal cavity through uric acid transporters. Intestinal uric acid is rapidly metabolized by the intestinal flora. Some intestinal bacteria regulate the proliferation and repair of intestinal epithelial cells by breaking down uric acid to produce acetic acid, lactic acid, and butyric acid, changing the number and distribution of uric acid transporters in the body, thereby affecting the transport and excretion of uric acid. However, the intestinal flora of people with high uric acid levels often show reduced diversity and abundance, especially the abundance of some beneficial bacteria such as Enterococcus faecalis is significantly reduced, which may be related to their decreased ability to break down uric acid. Therefore, promoting the decomposition of intestinal uric acid by regulating the intestinal flora is a promising method for lowering uric acid.

[0005] Research on lowering uric acid by regulating intestinal flora mainly focuses on the screening of probiotics that decompose uric acid. At present, there are some uric acid-lowering probiotic products on the market, but the survival rate of probiotics in the gastrointestinal digestive environment is low, the uric acid-lowering effect is uncertain, the required dosage is large, and the price is expensive, making it difficult to benefit all patient groups.

[0006] The invention of CN112401233A, "A meal replacement powder with a low-carbohydrate dietary structure and its preparation process", informs that the formula of the meal replacement powder is calculated by percentage as follows: 25%-35% of compound protein powder, 4%-10% of mixed oil microcapsule powder, 3%-12% of fast-fermenting dietary fiber, 6%-10% of medium-fermenting dietary fiber, 8%-10% of slow-fermenting dietary fiber, 2%-5% of protein particles, 5%-10% of grains, 2%-6% of fruit powder, 0.2%-0.4% of complex vitamins, 1%-2% of complex minerals, 3%-6% of functional seasoning packets, 0.01%-0.1% of potato extract, and 0.01%-0.2% of edible salt. Fast-fermenting dietary fiber includes oligofructose, etc.; medium-fermenting dietary fiber includes inulin; slow-fermenting dietary fiber includes citrus fiber, etc. The function of the meal replacement powder is to moderately reduce the intake of carbohydrates and fat. Summary of the invention

[0007] The technical problem to be solved by the present invention is to provide a dietary fiber granule which can achieve the effect of lowering uric acid.

[0008] In order to solve the above technical problems, the present invention provides a uric acid-lowering dietary fiber granules (a dietary fiber granules for lowering uric acid), which is composed of the following components in parts by weight:

[0009] 50-90 parts of inulin, 5-20 parts of oligofructose, and 5-20 parts of citrus fiber.

[0010] As an improvement of the uric acid-lowering dietary fiber granules of the present invention, it is composed of the following components by mass content:

[0011] 70-90 parts of inulin, 6-18 parts of oligofructose, and 5-15 parts of citrus fiber.

[0012] As a further improvement of the uric acid-lowering dietary fiber granules of the present invention, it is composed of the following components by mass content:

[0013] Inulin 80 parts, oligofructose 12 parts, citrus fiber 10 parts.

[0014] The present invention also provides a method for preparing the above-mentioned uric acid-lowering dietary fiber granules, which comprises sequentially performing the following steps:

[0015] 1) Place inulin, oligofructose and citrus fiber in a blender, stir at 50-60°C for 40-60 minutes (to ensure uniform distribution of the ingredients), and then pass through a 100-mesh sieve (or pass through a 100-mesh sieve after crushing);

[0016] 2) Sterilize the sieved mixture by microwave to obtain dietary fiber powder.

[0017] As an improvement to the preparation method of the uric acid-lowering dietary fiber granules of the present invention: the microwave sterilization is: sterilizing 80 g of the sieved mixture at a microwave power of 750 W for 20±2 minutes.

[0018] As a further improvement of the preparation method of the dietary fiber granules of the present invention: the dietary fiber granules are vacuum filled and packaged to ensure the sealing and appearance quality of the product.

[0019] Dietary fiber is a fermentation ingredient selectively utilized by intestinal bacteria, which can cause specific changes in the composition or activity of intestinal flora and have health benefits. The selection of specific types of dietary fiber and their combination can promote the proliferation of uric acid-decomposing bacteria, improve the ability of intestinal flora to decompose uric acid, and thus reduce blood uric acid levels. Regulating intestinal flora with dietary fiber can avoid the survival problem of probiotics, and dietary fiber has obvious price advantages. At present, there are no reports of anti-hyperuricemia functional products that use dietary fiber to regulate intestinal flora to reduce uric acid levels.

[0020] The dietary fiber granules of the present invention are prepared by mixing inulin, oligofructose and citrus fiber, have the effect of promoting intestinal uric acid metabolism, are suitable for a wide range of people, are highly safe, and can be taken daily for a long time.

[0021] In the formula of the dietary fiber granules for lowering uric acid provided by the present invention, inulin, oligofructose and citrus fiber combine the advantages of soluble and insoluble dietary fibers, play a synergistic role, help improve intestinal health, and also have a positive effect on lowering uric acid levels, and are a comprehensive intestinal health care product. The dietary fiber granules have pure ingredients, high safety, a wide range of applicable populations, and obvious price advantages, and can be taken as a health food for a long time, thereby providing a safer and more universal way of lowering uric acid for patients with hyperuricemia.

[0022] The present invention can improve the ability of intestinal flora to metabolize uric acid, promote the metabolism and excretion of uric acid, and can reduce inflammation associated with high uric acid, further promote the reduction of uric acid levels, and partially relieve the discomfort such as joint pain caused by gout, a complication of high uric acid. In addition, oligofructose can add sweetness to this product, without the need to add sweeteners and other sweet substances, avoiding additional sugar burden on patients.

[0023] The formula set according to the present invention is helpful for the intestinal excretion of uric acid; at the same time, by limiting the amount of citrus fiber added, the taste of the granules is adjusted, and the palatability of the dietary fiber granules is improved, which is conducive to long-term use by patients with hyperuricemia.

[0024] Compared with existing uric acid lowering products, the present invention has the following beneficial effects:

[0025] (1) The present invention proposes a method of lowering uric acid by regulating intestinal flora, which is different from supplementing probiotics. It has high safety, good bioavailability, significant uric acid lowering effect, and can benefit more patient groups;

[0026] (2) The present invention uses inulin, oligofructose and citrus fiber in combination, which has a significant synergistic effect, can improve the ability of intestinal bacteria to metabolize uric acid, and help uric acid excretion; at the same time, inulin and oligofructose can both reduce inflammation, further promoting the reduction of uric acid levels, and the composition has a rapid onset of uric acid reduction and a significant effect;

[0027] (3) The raw materials of the dietary fiber powder are easily available and inexpensive, the preparation method is simple, the safety is high, and it can be widely used as a food combination additive in other uric acid-lowering products. DETAILED DESCRIPTION

[0028] The present invention is further described below in conjunction with specific embodiments, but the protection scope of the present invention is not limited thereto:

[0029] Inulin can be purchased from Inui Company, with an effective content of ≥99%;

[0030] Oligofructose can be purchased from Jiahe Xuri Company, with an effective content of ≥99%;

[0031] Citrus fiber is available from Fiberstar Its water-soluble and water-insoluble dietary fiber is in a balanced ratio of 1:1.

[0032] The following parts are all by mass.

[0033] Example 1: A dietary fiber granule for lowering uric acid, the formula of the dietary fiber granule is: 70 parts of inulin, 6 parts of oligofructose, and 5 parts of citrus fiber.

[0034] The preparation method comprises the following steps:

[0035] 1) According to the formula, inulin, oligofructose and citrus fiber are placed in a blender, stirred at 50-60°C for 40-60 minutes to ensure that the ingredients are evenly distributed, and then crushed to pass through a 100-mesh sieve.

[0036] 2) The sieved mixture is sterilized by microwave, specifically: 80 g of the sieved mixture is sterilized at a microwave power of 750 W for 20 minutes to obtain a uric acid-lowering dietary fiber granules.

[0037] Then, in the conventional manner, the uric acid-lowering dietary fiber powder is vacuum-filled and packaged in a vacuum packaging machine to ensure the sealing and appearance quality of the product.

[0038] Example 2: A dietary fiber granule for lowering uric acid, the formula of the dietary fiber granule is: 80 parts of inulin, 12 parts of oligofructose, and 10 parts of citrus fiber.

[0039] The preparation method is the same as that of Example 1.

[0040] Example 3: A dietary fiber granule for lowering uric acid, the formula of the dietary fiber granule is: 90 parts of inulin, 18 parts of oligofructose, and 15 parts of citrus fiber.

[0041] The preparation method is the same as that of Example 1.

[0042] Experiment 1: 18 volunteers with hyperuricemia (voluntary subjects) were selected, 6 males and 6 females were randomly selected as the experimental group, and the remaining 3 males and 3 females were selected as the blank group.

[0043] The experimental group, the intervention period is four weeks, the dosage of uric acid-lowering dietary fiber granules is 7.5g / person. Each time; once a day in the morning and evening after washing with water. The diet is reasonably adjusted on the basis of food diversity and balanced nutrition: control and reduce the intake of high-purine foods, alcohol and fructose.

[0044] In the blank group, the uric acid-lowering dietary fiber granules were omitted, and the rest was the same as that of the experimental group; that is, the diet was the same as that of the experimental group.

[0045] The dietary fiber granules prepared in Example 2 above were used.

[0046] The following is the change in blood uric acid levels of the subjects before and after the intervention with dietary fiber powder.

[0047] Mr. Wang, male, 25 years old, weighing 75.6 kg and 173 cm tall, had a uric acid level of 467 μmol / L after physical examination in the hospital. He took the dietary fiber granules prepared in Example 2 and adjusted his diet. After four consecutive weeks, his uric acid level dropped to 381 μmol / L.

[0048] Mr. Li, male, 30 years old, weighing 80.2 kg and 178 cm tall, had a uric acid level of 429 μmol / L after physical examination in the hospital. He took the dietary fiber granules prepared in Example 2 and adjusted his diet. After four consecutive weeks, his uric acid level dropped to 344 μmol / L.

[0049] Lv, male, 37 years old, weighing 83.7 kg, and 181 cm tall, had a uric acid level of 524 μmol / L as determined by a physical examination at the hospital. After taking the dietary fiber granules prepared in Example 2 and adjusting his diet for four consecutive weeks, his uric acid level dropped to 408 μmol / L.

[0050] Chen, male, 26 years old, weighing 65.7 kg, and 167 cm tall, had a uric acid level of 451 μmol / L after physical examination in the hospital. After taking the dietary fiber granules prepared in Example 2 and adjusting his diet for four consecutive weeks, his uric acid level decreased to 366 μmol / L.

[0051] Liu, male, 32 years old, weighing 72.8 kg and 175 cm tall, had a uric acid level of 502 μmol / L as determined by a physical examination at the hospital. He took the dietary fiber granules prepared in Example 2 and adjusted his diet. After four consecutive weeks, his uric acid level dropped to 413 μmol / L.

[0052] Zhang, male, 28 years old, weighing 90.2 kg, and 186 cm tall, had a uric acid level of 487 μmol / L after physical examination in the hospital. He took the dietary fiber granules prepared in Example 2 and adjusted his diet. After four consecutive weeks, his uric acid level dropped to 398 μmol / L.

[0053] Lin, female, 32 years old, weighing 54.3 kg, and 157 cm tall, had a uric acid level of 406 μmol / L as determined by a hospital physical examination. After taking the dietary fiber granules prepared in Example 2 and adjusting her diet for four consecutive weeks, her uric acid level dropped to 342 μmol / L.

[0054] Ma Moumou, female, 28 years old, weighing 65.1kg and 169cm tall, had a uric acid level of 423μmol / L after physical examination in the hospital. After taking the dietary fiber granules prepared in Example 2 and adjusting her diet for four consecutive weeks, her uric acid level dropped to 306μmol / L.

[0055] Zhou, female, 41 years old, weighing 62.3 kg and 162 cm tall, had a uric acid level of 390 μmol / L as determined by a hospital physical examination. After taking the dietary fiber granules prepared in Example 2 and adjusting her diet for four consecutive weeks, her uric acid level dropped to 347 μmol / L.

[0056] Yang, female, 24 years old, weighing 55.6 kg and 160 cm tall, had a uric acid level of 381 μmol / L as determined by a hospital physical examination. After taking the dietary fiber granules prepared in Example 2 and adjusting her diet for four consecutive weeks, her uric acid level dropped to 324 μmol / L.

[0057] Li, female, 34 years old, weighing 52.6 kg, and 165 cm tall, had a uric acid level of 397 μmol / L as determined by a physical examination at the hospital. After taking the dietary fiber granules prepared in Example 2 and adjusting her diet for four consecutive weeks, her uric acid level dropped to 348 μmol / L.

[0058] Xu, female, 27 years old, weighing 58.7 kg and 155 cm tall, had a uric acid level of 411 μmol / L as determined by a hospital physical examination. After taking the dietary fiber granules prepared in Example 2 and adjusting her diet for four consecutive weeks, her uric acid level dropped to 351 μmol / L.

[0059] According to common sense, the normal value of uric acid for men is less than 420umol / L, and the normal value of uric acid for women is less than 360umol / L. Therefore, the uric acid levels of all subjects dropped to normal levels after the intervention.

[0060] Results for the blank group:

[0061] Xie, male, 30 years old, weight 69.1kg, height 174cm, the hospital physical examination showed that the uric acid level was 482μmol / L. After adjusting the diet for four consecutive weeks, the uric acid level dropped to 451μmol / L.

[0062] Zhang, male, 28 years old, weighing 73.5kg and 178cm tall, had a uric acid level of 456μmol / L after a physical examination at the hospital. After adjusting his diet for four consecutive weeks, his uric acid level dropped to 437μmol / L.

[0063] Min Moumou, male, 27 years old, weight 64.3kg, height 171cm, the hospital physical examination showed that the uric acid level was 477μmol / L. After adjusting the diet for four consecutive weeks, the uric acid level dropped to 436μmol / L.

[0064] You, female, 29 years old, weighing 56.2kg and 157cm tall, had a uric acid level of 402μmol / L after a physical examination at the hospital. After adjusting her diet for four consecutive weeks, her uric acid level dropped to 385μmol / L.

[0065] Xue Moumou, female, 21 years old, weighing 61.7kg and 169cm tall, had a uric acid level of 389μmol / L after a physical examination at the hospital. After adjusting her diet for four consecutive weeks, her uric acid level dropped to 376μmol / L.

[0066] Yang Moumou, female, 23 years old, weighing 52.8kg and 165cm tall, had a uric acid level of 415μmol / L after a physical examination at the hospital. After adjusting her diet for four consecutive weeks, her uric acid level dropped to 398μmol / L.

[0067] Experiment 2: Select female hyperuricemia patients with uric acid values ​​of 370-500 μmol / L and male hyperuricemia patients with uric acid values ​​of 420-550 μmol / L, aged 20-35 years, and screen patients with similar physical conditions (i.e., not diabetic or hyperlipidemia patients); divide them into 3 experimental groups, each with 24 hyperuricemia patients (12 males and 12 females), and conduct experiments according to the method described in Experiment 1. Experiment Group A takes the dietary fiber granules described in Example 1, Experiment Group B takes the dietary fiber granules described in Example 2, and Experiment Group C takes the dietary fiber granules described in Example 3. After four weeks, the changes in uric acid values ​​are shown in Table 1 below:

[0068] Table 1

[0069]

[0070] The formulations of Comparative Examples 1 to 3 are as described in Table 2 below, and then the experiment was carried out in the manner described in Experiment 2, and the results obtained are as described in Table 2 below.

[0071] Table 2

[0072]

[0073] Comparative Example 4-1: The "fructose oligosaccharide" in Example 1 was replaced with "xylooligosaccharide", the dosage remained unchanged, and the rest was the same as Example 1.

[0074] Comparative Example 4-2: The "fructoligosaccharide" in Example 1 was replaced with "isomalto-oligosaccharide", the dosage remained unchanged, and the rest was the same as Example 1.

[0075] Comparative Example 5-1: The "citrus fiber" in Example 1 was replaced with "wheat bran fiber", the dosage remained unchanged, and the rest was the same as Example 1.

[0076] Comparative Example 5-2: The "citrus fiber" in Example 1 was replaced with "sweet potato fiber", the dosage remained unchanged, and the rest was the same as Example 1.

[0077] The dietary fiber granules prepared in Comparative Examples 4-1 to 5-2 were subjected to experiments according to the method described in Experiment 2. The results are described in Table 3 below.

[0078] Table 3

[0079]

[0080]

[0081] Finally, it should be noted that the above examples are only some specific embodiments of the present invention. Obviously, the present invention is not limited to the above embodiments, and there are many variations. All variations that can be directly derived or associated with the content disclosed by a person skilled in the art should be considered as the protection scope of the present invention.

Claims

1. A dietary fiber granule for lowering uric acid, characterized in that It is composed of the following components by weight: 50-90 parts of inulin, 5-20 parts of oligofructose, and 5-20 parts of citrus fiber.

2. The uric acid-lowering dietary fiber granules according to claim 1, characterized in that It is composed of the following ingredients by mass: 70-90 parts of inulin, 6-18 parts of oligofructose, and 5-15 parts of citrus fiber.

3. The uric acid-lowering dietary fiber granules according to claim 1, characterized in that It is composed of the following ingredients by mass: Inulin 80 parts, oligofructose 12 parts, citrus fiber 10 parts.

4. The method for preparing the uric acid-lowering dietary fiber granules according to any one of claims 1 to 3, characterized in that Follow these steps in order: 1) Place inulin, oligofructose and citrus fiber into a blender, stir at 50-60°C for 40-60 minutes, and then pass through a 100-mesh sieve; 2) The sieved mixture is sterilized by microwave to obtain uric acid lowering dietary fiber granules.

5. The method for preparing the uric acid-lowering dietary fiber granules according to claim 4, characterized in that: The microwave sterilization is as follows: 80 g of the sieved mixture is sterilized at a microwave power of 750 W for 20±2 minutes.

6. The method for preparing the uric acid-lowering dietary fiber granules according to claim 4 or 5, characterized in that: Uric acid lowering dietary fiber granules are vacuum filled and packaged.

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