Plunger pump column filling device
The method of driving two-stage heavy-load springs by hydraulic devices solves the problems of large space occupation, high cost and insufficient pressure in the traditional chromatographic column filling method, and achieves efficient and safe column filling.
Patent Information
- Application Number
- CN202510129860.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-02-05
- Publication Date
- 2025-04-25
AI Technical Summary
The existing chromatographic column filling methods have problems such as large space occupation, high cost and safety hazards, and traditional plunger pumps are difficult to obtain particularly high pressure.
The hydraulic device is used to drive the two-stage heavy-duty spring, and the plunger rod is pushed through the second-stage spring. The first-stage spring realizes automatic reset of the plunger rod, achieving efficient filling of the chromatographic column.
Through the combination of hydraulic devices and two-stage springs, high-pressure filling of the chromatographic column is achieved, reducing space occupancy and cost, while improving safety and filling efficiency.
Smart Images
Figure CN119881187A_ABST
Abstract
Description
Technical Field
[0001] This patent mainly relates to a filling device for a chromatographic column with a plunger pump structure. Background Art
[0002] Chromatographic column filling is usually done by connecting a gas cylinder, a gas booster pump, or a liquid chromatography pump to a chromatographic packing cavity, and then, under the action of fluid pressure, the suspended packing is pressed into the chromatographic column along with the liquid. Generally speaking, high-pressure gas cylinders have pressures of tens of MPa; gas booster pumps can amplify the pressure or multi-stage amplify the pressure, and after connecting to an air compressor, they can obtain pressures of hundreds of MPa or higher; the maximum pressure of existing commercial liquid chromatography pumps is about 25,000 Psi (about 172 MPa).
[0003] For the above three methods, the gas cylinder pressure is limited, takes up space, and has safety hazards; the gas booster pump needs to be used in conjunction with an air compressor, which has high electrical and space requirements, and the cost and use cost are also high; the purchase cost and maintenance cost of the liquid chromatography pump are both very high.
[0004] Patent CN118671250A discloses a plunger pump that can be directly or indirectly connected to a packing cavity to fill a chromatographic column. Compared with the above three pressurization methods, this solution takes up less space and is relatively economical in terms of implementation and use costs. Based on the above technology, this patent further optimizes the structure and introduces a two-stage spring, which can better achieve pressure control and automatic resetting of the plunger rod. By directly or indirectly connecting to the chromatographic packing cavity, it can be directly used to fill a chromatographic column. Summary of the invention
[0005] Traditional plunger pumps are driven directly by motors, or by motors combined with worms, which can accurately control the flow rate or control the pressure output. However, due to the limited output power of the motor, it is generally difficult to obtain a particularly high pressure. This patent drives a two-stage heavy-load spring through a hydraulic device, the second-stage heavy-load spring is used to push the plunger rod, and the first-stage heavy-load spring is used to return the plunger rod after the thrust is removed. Specifically, there is a physical partition at one end of the plunger rod away from the plunger pump cavity, which is connected to the plunger rod and moves synchronously. The first-stage spring is located between the physical partition and the plunger pump cavity, and the second-stage spring is located between the hydraulic device and the physical partition. When filling the column, the thrust device pushes the second-stage spring, the second-stage spring is compressed, and the rebound force of the second-stage spring acts on the physical partition, the physical partition moves with the plunger rod, and the physical partition compresses the first-stage spring. Because the liquid is incompressible (micro), when the plunger pump moves, the movement volume of the plunger rod is generally much larger than the outflow volume of the liquid from the cavity, and the liquid in the plunger pump cavity will be compressed to generate pressure. By connecting the plunger pump directly or indirectly to the packing chamber, the required pressure can be provided for filling the chromatographic column. When the thrust device removes the pressure, the secondary spring pressure is also removed, and the primary spring pushes the physical partition to drive the plunger rod to move in the opposite direction, so that the plunger rod returns to its original position.
[0006] Since the rebound force of the spring can be calculated according to the compression ratio of the spring, the total rebound force of the two-stage spring can be calculated separately according to the compression ratio of the spring. The rebound force of the secondary spring minus the rebound force of the primary spring is the theoretical thrust of the plunger rod, which can be divided by the area of the plunger rod to obtain the theoretical pressure of the fluid.
[0007] The elastic force of the spring itself is reproducible within its service life, so the final output pressure of the plunger pump can be indicated by the compression distance. BRIEF DESCRIPTION OF THE DRAWINGS
[0008] Figure 1 A schematic structural diagram of the plunger pump column filling device provided by the present invention. DETAILED DESCRIPTION
[0009] The present invention will be further described below in conjunction with the accompanying drawings.
[0010] like Figure 1As shown, it is a schematic diagram of the structure of a plunger pump provided by the present invention, including a chromatographic column 1, an interface 2, a plunger pump cavity 3, a packing cavity 4, a plunger rod 5, a primary spring 6, a physical partition 7, a secondary spring 8 and a thrust device 9, wherein the plunger rod and the physical partition can be an integral structure, or fixed by a mechanical structure to maintain the synchronous movement of the physical partition and the plunger rod. The interface is used to insert and fix the capillary, the plunger pump cavity is used to accommodate the plunger rod, the packing cavity is used to store the homogenized packing, the primary spring is used to reset the plunger rod, the secondary spring is used to provide thrust for the plunger rod, and the physical partition is used to distinguish the functions of the two-stage springs. Before filling the chromatographic column, first fill the plunger pump cavity with liquid, then store the packing slurry in the packing cavity, and then insert the capillary into the interface position and tighten it, while making the capillary contact with the packing. After that, the primary spring is placed between the plunger pump cavity and the physical partition, and the secondary spring is placed between the physical partition and the thrust device, and the primary spring and the secondary spring are separated by the physical partition. Take the jack in the hydraulic device as an example to explain the specific working process. When filling the column, the jack rises and pushes the secondary spring. The secondary spring is compressed, and its rebound force acts on the physical partition. The physical partition directly pushes the plunger rod to give liquid pressure to generate the pressure required for filling the column to push the chromatographic filler into the chromatographic column. At the same time, the physical partition compresses the primary spring. After the chromatographic column is filled, the jack removes the pressure, and the pressure of the secondary spring is removed accordingly. Under the rebound force of the primary spring, the physical partition pushes the plunger rod to move in the opposite direction, so that the plunger rod returns to its original position.
[0011] The present invention is not limited to the above-mentioned embodiments, and all embodiments obtained without any creative work are within the protection scope of the present invention.
Claims
1. A chromatographic column filling device driven by a plunger pump, characterized in that: The thrust and reset reverse thrust of the plunger rod are provided by a two-stage spring; the two-stage springs are functionally differentiated by a physical partition, the first-stage spring is used for resetting the plunger rod, and the second-stage spring is used for providing thrust for the plunger rod; the device can be connected to the chromatographic packing cavity directly or indirectly and used for filling the chromatographic column.
2. The device according to claim 1, characterized in that The secondary spring can be driven by a hydraulic device, a screw rod, or an electromagnetic force to provide thrust for the secondary spring. When the thrust acts on the secondary spring, the spring is compressed, and the spring rebound force pushes the physical partition to provide direct thrust for the plunger rod, and the partition simultaneously compresses the primary spring. When the thrust is withdrawn, the secondary spring and the primary spring rebound at the same time, and the primary spring pushes the partition to reset the plunger rod. Each level of spring can be composed of one or more springs in parallel.
3. The device according to claim 1, characterized in that The thrust acts on the secondary spring. The total elastic force of the secondary spring minus the rebound force of the primary spring is the final thrust of the plunger rod. The thrust acting on the plunger rod can be calculated through the compression ratio of the two-stage spring to finally reach the required pressure.
4. The device according to claim 1, characterized in that The packing cavity can be directly or indirectly connected to the chromatographic column for filling.
5. The device according to claim 1, characterized in that The material of the plunger pump cavity can be hard materials such as ceramics, hard plastics, alloys, etc.; the material of the plunger rod can be hard materials such as ceramics, hard plastics, alloys, etc.
6. The device according to claim 1, characterized in that The contact point between the plunger rod and the plunger pump cavity can be sealed by a sealing ring or a combination of multiple sealing rings to ensure that there is no leakage.
7. The device according to claim 1, characterized in that Independent or shared fluid interfaces can be reserved for liquid replenishment, liquid delivery, and pressure relief. The interfaces can be in a fully open, partially open, or fully closed state, and the selection should be based on functional requirements.
8. The device according to claim 1, characterized in that A pressure gauge can be connected and a positioning mark showing the spring compression amount can be added to monitor the real-time pressure; a filter can be built into the flow path to protect the plunger rod and sealing ring, or to divide the fluid functional area.