Bacteriostatic temperature-sensitive no-wash hand-washing gel containing hydrophilic ozone oil emulsion and preparation method of bacteriostatic temperature-sensitive no-wash hand-washing gel

Abstract

The invention discloses a bacteriostatic temperature-sensitive no-wash hand washing gel containing hydrophilic ozone oil emulsion and a preparation method thereof, and the bacteriostatic temperature-sensitive no-wash hand washing gel comprises the following components: 30-55 wt% of hydrophilic ozonized oil emulsion, 5-10 wt% of glycerol, 8-15 wt% of propylene glycol, 5-8 wt% of carbomer 940, 1-2 wt% of vitamin E, 0.1-1 wt% of triethanolamine, 0.3-2 wt% of benzethonium chloride, 0.3-0.5 wt% of phenoxyethanol, 0.5-2 wt% of 1, 2-hexanediol, 1-3 wt% of plant essential oil, and the balance of deionized water. The content of ozonized oil in the hydrophilic ozonized oil emulsion is 0.5-5 wt%; the prepared bacteriostatic temperature-sensitive no-wash hand-washing gel containing the hydrophilic ozone oil emulsion has a relatively strong bacteriostatic effect on pathogenic bacteria, and can inhibit rapid breeding of residual and newly added bacteria on hands, so that the hands are kept clean for a long time, frequent use of hand sanitizers is avoided, and the gel is milder, is very suitable for dry skin and being used in winter, and has a good application prospect. A certain skin nourishing effect is achieved.

Description

Technical Field

[0001] The invention belongs to the technical field of daily necessities and relates to an antibacterial hand washing gel, in particular to an antibacterial temperature-sensitive wash-free hand washing gel containing a hydrophilic ozone oil emulsion and a preparation method thereof. Background Art

[0002] Ozone (O3) is a natural antimicrobial agent with excellent properties, including antimicrobial activity, anti-inflammatory properties, immunomodulatory properties, anti-hypoxia properties, and a zero-residue nature. By reacting ozone with unsaturated double bonds in vegetable oils and storing the ozone in the oils, a relatively stable, commercially available ozone source can be obtained. Ozonated vegetable oils can produce bactericidal activity by decomposing and producing ozone, oxygen, and hydrogen peroxide (H2O2).

[0003] Ozone oil has drawbacks such as poor stability, poor water solubility, unpleasant odor, and strong irritation during use, which limit its widespread application. Therefore, developing a suitable ozone oil formulation that overcomes these drawbacks while maintaining its antibacterial properties is of great significance for its widespread application.

[0004] Hand sanitizer is an indispensable cleaning product in our daily lives. With technological advancements, the use of new surfactants, additives, and mild, natural disinfectants, along with pump-type packaging, has enabled hand sanitizers to offer both moisturizing and antibacterial properties. This has led to increased awareness of daily health protection and a surge in demand for antibacterial and bactericidal products. Disposable hand sanitizers are becoming even more popular. Currently, commercially available antibacterial hand gels are mostly formulated with 75% medical alcohol. While these gels can effectively kill a wide range of pathogens, they can also cause skin dehydration and dryness, potentially leading to skin barrier damage. Therefore, developing a hand sanitizer that is both gentle and effective in removing stains and achieving antibacterial properties while being easy to use is crucial. Summary of the Invention

[0005] In view of the shortcomings of the existing technology, the purpose of the present invention is to provide an antibacterial temperature-sensitive hand-disposable hand gel containing a hydrophilic ozone oil emulsion and a preparation method thereof, which has bactericidal and cleaning effects, is low in irritation, and can simultaneously achieve skin care and antibacterial effects.

[0006] In order to achieve the above object, the present invention adopts the following technical solutions:

[0007] Disclosed is an antibacterial temperature-sensitive hand-disposable hand gel containing a hydrophilic ozone oil emulsion, comprising: 30-55 wt% of the hydrophilic ozonated oil emulsion, 5-10 wt% of glycerol, 8-15 wt% of propylene glycol, 5-8 wt% of carbomer 940, 1-2 wt% of vitamin E, 0.1-1 wt% of triethanolamine, 0.3-2 wt% of benzethonium chloride, 0.3-0.5 wt% of phenoxyethanol, 0.5-2 wt% of 1,2-hexanediol, 1-3 wt% of plant essential oil, and the balance being deionized water;

[0008] The content of ozonated oil in the hydrophilic ozonated oil emulsion is 0.5-5wt%.

[0009] The present invention also has the following technical features:

[0010] Preferably, the components of the hydrophilic ozonated oil emulsion include: 10-30 wt% Tween-80, 3-10 wt% polyethylene glycol, 0.5-5 wt% ozonated oil, 1-15 wt% isopropyl myristate, and the balance is deionized water.

[0011] Preferably, the ozone content in the ozonated oil is 100-500 mg / L.

[0012] Furthermore, the ozonated oil is a vegetable oil-based ozonated oil, specifically including any one of olive oil-based ozonated oil, sunflower oil-based ozonated oil and sesame oil-based ozonated oil.

[0013] Preferably, the ozonated oil is olive oil-based ozonated oil.

[0014] Preferably, the plant essential oil includes any one of lavender essential oil, tea tree essential oil, rose essential oil, and lemon essential oil.

[0015] The present invention also protects a method for preparing the antibacterial temperature-sensitive hand sanitizer gel containing the hydrophilic ozone oil emulsion as described above, which is characterized by comprising the following steps:

[0016] Step 1: Add glycerol and propylene glycol to carbomer 940 in parts by weight and stir until the carbomer 940 is completely soaked to obtain a mixed emulsion;

[0017] Step 2: Add distilled water to the mixed emulsion prepared in step 1 and heat with stirring. After the temperature rises to 50-60° C., add benzethonium chloride, phenoxyethanol, 1,2-hexanediol, and vitamin E. Stir until completely swollen, then stop heating and cool to room temperature to obtain a gel.

[0018] Step 3: Add the ozonated oil emulsion to the gel prepared in step 2 and stir evenly, then add triethanolamine to adjust to neutrality, add plant essential oil, and stir evenly to obtain an antibacterial temperature-sensitive hand sanitizer gel containing a hydrophilic ozone oil emulsion.

[0019] Compared with the prior art, the present invention has the following technical effects:

[0020] The present invention uses ozonated olive oil to prepare an oil-in-water ozonated oil emulsion in a microcapsule-like form, which significantly improves the stability of the ozonated oil and makes it hydrophilic. The ozonated oil is supplemented with glycerin, propylene glycol, carbomer 940, triethanolamine, vitamin E, benzethonium chloride and phenylethanolamine to prepare a wash-free hand sanitizer gel. The components cooperate with each other, and the gel not only has a sterilization effect comparable to that of existing wash-free hand sanitizers, but also has skin moisturizing and antioxidant capabilities, thereby avoiding phenomena such as dryness caused by skin moisture loss and skin barrier damage. The vitamin E can react with a small amount of ozone released by the microcapsules, thereby stabilizing the ozone, reducing its decomposition and volatilization, and further improving the stability of the ozonated oil, so that the hand sanitizer gel of the present invention can be stored for a long time. At the same time, the added vitamin E comes into contact with the skin. It forms a protective barrier to prevent ozone from stimulating the vitamin E in human skin. Glycerin feels soft when used and can produce a comfortable feeling after use. It has good lubricating and moisturizing effects, making the skin moisturized and shiny. When used, ingredients such as vitamin E and glycerin first contact the skin to form a protective layer for the skin. Through rubbing and smearing actions, the microparticle structure of the water-in-oil ozonated oil emulsion is destroyed, causing the ozonated oil to be released. Under the action of human body temperature, ozone evaporates, and has a strong antibacterial effect on pathogenic bacteria such as Escherichia coli, Staphylococcus aureus, Candida albicans, and Pseudomonas aeruginosa. It can inhibit the rapid growth of residual and new bacteria on the hands, thereby keeping hands clean for a long time and avoiding the frequent use of hand sanitizer. It is more gentle and very suitable for dry skin and winter use, and has a certain skin-nourishing effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 The particle size and zeta potential detection spectrum of the hydrophilic ozonated oil emulsion prepared in Example 1;

[0022] Figure 2 This is a photo of the diffusion test of the hydrophilic ozonated oil emulsion prepared in Example 1 with Sudan III dye and methylene blue dye;

[0023] Figure 3 This is a photo of the dilution stability test of the hydrophilic ozonated oil emulsion prepared in Example 1;

[0024] Figure 4 This is a photo of the antibacterial temperature-sensitive hand sanitizer gel containing the hydrophilic ozone oil emulsion prepared in Example 1. DETAILED DESCRIPTION

[0025] The specific contents of the present invention are further explained in detail below with reference to the embodiments.

[0026] The reagents, methods, and equipment used in the present invention are conventional in the art. The experimental methods in the following examples, where specific experimental conditions are not specified, generally follow conventional experimental conditions. Unless otherwise specified, the reagents and raw materials used in the present invention are commercially available.

[0027] The ozonated oil used in the present invention is commercially available ozonated oil, wherein the ozone content is 100 to 500 mg / L;

[0028] The average molecular weight of polyethylene glycol is 400.

[0029] The hydrophilic ozonated oil emulsion of the present invention is prepared according to the following method: at room temperature, Tween-80 and polyethylene glycol are accurately weighed and stirred evenly with a magnetic stirrer, then the ozonated oil and isopropyl myristate are slowly added until they are completely mixed, then deionized water is slowly added while stirring until the system changes from a colloidal state to a clear and transparent liquid state, then the aqueous phase is continuously added until a sufficient amount is obtained, and then ultrasonic treatment is performed to obtain the hydrophilic ozonated oil emulsion.

[0030] Example 1:

[0031] This embodiment provides an antibacterial temperature-sensitive hand sanitizer gel containing a hydrophilic ozone oil emulsion, the components of which include: 30 wt% of the hydrophilic ozonated oil emulsion, 5 wt% of glycerol, 8 wt% of propylene glycol, 5 wt% of carbomer 940, 1 wt% of vitamin E, 1 wt% of triethanolamine, 1 wt% of benzethonium chloride, 0.5 wt% of phenoxyethanol, 1 wt% of 1,2-hexanediol, 2 wt% of rose essential oil, and the balance being deionized water;

[0032] The components of the hydrophilic ozonated oil emulsion include: 12 wt% of Tween-80, 4 wt% of polyethylene glycol, 1.5 wt% of olive oil-based ozonated oil, 7 wt% of isopropyl myristate, and the balance is deionized water;

[0033] The preparation method of the antibacterial temperature-sensitive hand-washing gel containing a hydrophilic ozone oil emulsion comprises the following steps:

[0034] Step 1: Add glycerol and propylene glycol to carbomer 940 in parts by weight and stir until the carbomer 940 is completely soaked to obtain a mixed emulsion;

[0035] Step 2: Add distilled water to the mixed emulsion prepared in step 1 and heat with stirring. After the temperature reaches 50° C., add benzethonium chloride, phenoxyethanol, 1,2-hexanediol, and vitamin E. Stir until completely swollen, then stop heating and cool to room temperature to obtain a gel.

[0036] Step 3: Add the ozonated oil emulsion to the gel prepared in step 2 and stir evenly, then add triethanolamine to adjust to neutrality, add plant essential oil, and stir evenly to obtain an antibacterial temperature-sensitive hand sanitizer gel containing a hydrophilic ozone oil emulsion.

[0037] Particle size can be used as a key indicator of emulsion and an intuitive reflection of emulsification performance. PDI is an indicator used to describe the uniform distribution of emulsion droplets. Generally, the value of PDI is between 0 and 1, and the lower the value of PDI, the more uniform the distribution. When the PDI index is lower than 0.3, it is considered to have good uniform dispersion characteristics. To evaluate the stability of hydrophilic ozonated oil emulsion, a nanoparticle size analyzer was used to detect the particle size and PDI of the ozonated oil nanoemulsion. The hydrophilic ozonated oil emulsion was appropriately diluted to prevent the influence of multiple scattering effects. Each sample was tested 3 times. The results of particle size and Zeta potential are shown in Figure 2. Figure 1 The ozonated oil emulsion prepared according to the recipe had an average particle size of 178.9±2.42nm, a PDI index of 0.22±0.02, and a zeta potential of 24.23±0.9mV. The results showed that the ozonated oil nanoemulsion was well dispersed and had a strong charge. The high charge was less likely to cause aggregation and precipitation, which improved the stability of the system.

[0038] Figure 2 , Figure 3 To evaluate the hydrophilicity of ozonated oil emulsion;

[0039] Prepare two ozonated oil emulsion samples, add Sudan III dye and methylene blue dye respectively, and observe the diffusion of dye in the two samples after standing for 2 minutes. Figure 2 As shown: the oil-soluble dye Sudan III diffuses less than the water-soluble dye methylene blue, indicating that the ozonated oil emulsion is hydrophilic.

[0040] The ozonated oil emulsion is a milky white uniform liquid, which can be diluted by adding distilled water at a ratio of 1:9. Figure 3 As shown, there is no floating oil on the surface, and a light blue opalescence is visible after dilution. Ozonized oil itself has poor solubility and appears insoluble in water in a system with water as the medium. However, after emulsion preparation, its solubility changes significantly, showing a clear opalescence, no floating oil on the surface, and remains stable and uniform after dilution with water.

[0041] Figure 4 This is a photo of the antibacterial temperature-sensitive hand-washing gel containing hydrophilic ozone oil emulsion prepared in Example 1. Figure 4 It can be seen that the texture is uniform and moist.

[0042] Example 2:

[0043] This embodiment provides an antibacterial temperature-sensitive hand sanitizer gel containing a hydrophilic ozone oil emulsion, the components of which include: 55 wt% of the hydrophilic ozonated oil emulsion, 10 wt% of glycerol, 15 wt% of propylene glycol, 8 wt% of carbomer 940, 2 wt% of vitamin E, 0.1 wt% of triethanolamine, 0.3 wt% of benzethonium chloride, 0.3 wt% of phenoxyethanol, 0.5 wt% of 1,2-hexanediol, 1 wt% of lavender essential oil, and the balance being deionized water;

[0044] The components of the hydrophilic ozonated oil emulsion include: 15 wt% of Tween-80, 5 wt% of polyethylene glycol, 2 wt% of olive oil-based ozonated oil, 8 wt% of isopropyl myristate, and the balance is deionized water;

[0045] The preparation method of the antibacterial temperature-sensitive hand-washing gel containing a hydrophilic ozone oil emulsion comprises the following steps:

[0046] Step 1: Add glycerol and propylene glycol to carbomer 940 in parts by weight and stir until the carbomer 940 is completely soaked to obtain a mixed emulsion;

[0047] Step 2: Add distilled water to the mixed emulsion prepared in step 1 and heat with stirring. After the temperature reaches 60° C., add benzethonium chloride, phenoxyethanol, 1,2-hexanediol, and vitamin E. Stir until completely swollen, then stop heating and cool to room temperature to obtain a gel.

[0048] Step 3: Add the ozonated oil emulsion to the gel prepared in step 2 and stir evenly, then add triethanolamine to adjust to neutrality, add plant essential oil, and stir evenly to obtain an antibacterial temperature-sensitive hand sanitizer gel containing a hydrophilic ozone oil emulsion.

[0049] Example 3:

[0050] This embodiment provides an antibacterial temperature-sensitive hand sanitizer gel containing a hydrophilic ozone oil emulsion, the components of which include: 40 wt% of the hydrophilic ozonated oil emulsion, 8 wt% of glycerol, 10 wt% of propylene glycol, 6 wt% of carbomer 940, 1.5 wt% of vitamin E, 0.5 wt% of triethanolamine, 2 wt% of benzethonium chloride, 0.4 wt% of phenoxyethanol, 2 wt% of 1,2-hexanediol, 3 wt% of tea tree essential oil, and the balance being deionized water;

[0051] The components of the hydrophilic ozonated oil emulsion include: 20 wt% of Tween-80, 7 wt% of polyethylene glycol, 3 wt% of sunflower seed oil ozonated oil, 9 wt% of isopropyl myristate, and the balance is deionized water;

[0052] The preparation method of the antibacterial temperature-sensitive hand-washing gel containing a hydrophilic ozone oil emulsion comprises the following steps:

[0053] Step 1: Add glycerol and propylene glycol to carbomer 940 in parts by weight and stir until the carbomer 940 is completely soaked to obtain a mixed emulsion;

[0054] Step 2: Add distilled water to the mixed emulsion prepared in step 1 and heat with stirring. After the temperature reaches 55° C., add benzethonium chloride, phenoxyethanol, 1,2-hexanediol, and vitamin E. Stir until completely swollen, then stop heating and cool to room temperature to obtain a gel.

[0055] Step 3: Add the ozonated oil emulsion to the gel prepared in step 2 and stir evenly, then add triethanolamine to adjust to neutrality, add plant essential oil, and stir evenly to obtain an antibacterial temperature-sensitive hand sanitizer gel containing a hydrophilic ozone oil emulsion.

[0056] Table 1 shows the antibacterial evaluation of the antibacterial, thermosensitive, and disposable hand sanitizer gels containing hydrophilic ozone oil emulsions prepared in Examples 1 to 3. Antibacterial experiments were conducted using potassium penicillin as the control group. 5 mm diameter discs were punched and sterilized, and the test bacteria were streaked onto solid culture plates and incubated overnight at 37°C until distinct bacterial plaques were visible. An appropriate number of mature colonies were then selected and placed in 15 ml of liquid culture medium and incubated at 37°C for 6-8 hours. When the OD600 reached 0.5, 100 μL of the bacterial solution was spread on the surface of the solid culture medium. Sterilized filter paper was attached to the four corners, and the ozonated oil emulsion hand sanitizer gel, potassium penicillin, and sterile water were added dropwise, respectively, and incubated overnight at 37°C. Table 1 shows that the antibacterial, thermosensitive, and disposable hand sanitizer gels containing hydrophilic ozone oil emulsions in Examples 1 to 3 exhibited good antibacterial activity against Staphylococcus aureus, Escherichia coli, and Candida albicans, as indicated by the diameters of the inhibition zones.

[0057] Table 1 Evaluation of antibacterial properties of hand washing gel

[0058] Example 1 Example 2 Example 3 control group Staphylococcus aureus 15.76 15.98 16.13 15.21 Escherichia coli 13.12 13.41 13.67 13.23 Candida albicans 15.45 15.63 15.89 13.21

[0059] The antibacterial time of application of the antibacterial thermosensitive hand sanitizer gel containing the hydrophilic ozone oil emulsion of Examples 1 to 3 was tested. The results showed that the number of tested microorganisms did not increase significantly within 4-6 hours, but increased significantly after 6 hours, indicating that the sample had a good antibacterial effect within 4-6 hours.

[0060] Example 4:

[0061] This embodiment provides an antibacterial temperature-sensitive hand sanitizer gel containing a hydrophilic ozone oil emulsion, the components of which include: 45 wt% of the hydrophilic ozonated oil emulsion, 6 wt% of glycerol, 12 wt% of propylene glycol, 7 wt% of carbomer 940, 1.2 wt% of vitamin E, 0.3 wt% of triethanolamine, 1.5 wt% of benzethonium chloride, 0.5 wt% of phenoxyethanol, 1.5 wt% of 1,2-hexanediol, 1.5 wt% of lemon essential oil, and the balance being deionized water;

[0062] The components of the hydrophilic ozonated oil emulsion include: 30 wt% of Tween-80, 10 wt% of polyethylene glycol, 5 wt% of sunflower oil-based ozonated oil, 15 wt% of isopropyl myristate, and the balance is deionized water;

[0063] The preparation method of the antibacterial temperature-sensitive hand-washing gel containing a hydrophilic ozone oil emulsion comprises the following steps:

[0064] Step 1: Add glycerol and propylene glycol to carbomer 940 in parts by weight and stir until the carbomer 940 is completely soaked to obtain a mixed emulsion;

[0065] Step 2: Add distilled water to the mixed emulsion prepared in step 1 and heat with stirring. After the temperature reaches 50° C., add benzethonium chloride, phenoxyethanol, 1,2-hexanediol, and vitamin E. Stir until completely swollen, then stop heating and cool to room temperature to obtain a gel.

[0066] Step 3: Add the ozonated oil emulsion to the gel prepared in step 2 and stir evenly, then add triethanolamine to adjust to neutrality, add plant essential oil, and stir evenly to obtain an antibacterial temperature-sensitive hand sanitizer gel containing a hydrophilic ozone oil emulsion.

[0067] Example 5:

[0068] This embodiment provides an antibacterial temperature-sensitive hand sanitizer gel containing a hydrophilic ozone oil emulsion, the components of which include: 45 wt% of the hydrophilic ozonated oil emulsion, 6 wt% of glycerol, 12 wt% of propylene glycol, 7 wt% of carbomer 940, 1.2 wt% of vitamin E, 0.3 wt% of triethanolamine, 1.5 wt% of benzethonium chloride, 0.5 wt% of phenoxyethanol, 1.5 wt% of 1,2-hexanediol, 1.5 wt% of rose essential oil, and the balance being deionized water;

[0069] The components of the hydrophilic ozonated oil emulsion include: 10 wt% of Tween-80, 3 wt% of polyethylene glycol, 0.5 wt% of sesame oil-based ozonated oil, 1 wt% of isopropyl myristate, and the balance is deionized water;

[0070] The preparation method of the antibacterial temperature-sensitive hand-washing gel containing a hydrophilic ozone oil emulsion comprises the following steps:

[0071] Step 1: Add glycerol and propylene glycol to carbomer 940 in parts by weight and stir until the carbomer 940 is completely soaked to obtain a mixed emulsion;

[0072] Step 2: Add distilled water to the mixed emulsion prepared in step 1 and heat with stirring. After the temperature reaches 50° C., add benzethonium chloride, phenoxyethanol, 1,2-hexanediol, and vitamin E. Stir until completely swollen, then stop heating and cool to room temperature to obtain a gel.

[0073] Step 3: Add the ozonated oil emulsion to the gel prepared in step 2 and stir evenly, then add triethanolamine to adjust to neutrality, add plant essential oil, and stir evenly to obtain an antibacterial temperature-sensitive hand sanitizer gel containing a hydrophilic ozone oil emulsion.

[0074] It should be noted that the above embodiments are only used to illustrate the technical solution of the present invention, rather than to limit it; without departing from the concept of the present invention, the deduction or replacement made by those skilled in the art shall fall within the scope of protection of the present invention.

Claims

1. An antibacterial thermosensitive hand sanitizer gel containing a hydrophilic ozone oil emulsion, characterized in that: The components include: 30-55wt% of hydrophilic ozonated oil emulsion, 5-10wt% of glycerol, 8-15wt% of propylene glycol, 5-8wt% of carbomer 940, 1-2wt% of vitamin E, 0.1-1wt% of triethanolamine, 0.3-2wt% of benzethonium chloride, 0.3-0.5wt% of phenoxyethanol, 0.5-2wt% of 1,2-hexanediol, 1-3wt% of plant essential oil, and the balance is deionized water; The content of ozonated oil in the hydrophilic ozonated oil emulsion is 0.5-5wt%.

2. The antibacterial thermosensitive hand-free hand gel containing a hydrophilic ozone oil emulsion according to claim 1, characterized in that: The components of the hydrophilic ozonated oil emulsion include: 10-30wt% of Tween-80, 3-10wt% of polyethylene glycol, 0.5-5wt% of ozonated oil, 1-15wt% of isopropyl myristate, and the balance is deionized water.

3. The antibacterial thermosensitive hand-free hand gel containing a hydrophilic ozone oil emulsion according to claim 2, characterized in that: The ozone content in the ozonated oil is 100-500 mg / L.

4. The antibacterial thermosensitive hand-free hand gel containing a hydrophilic ozone oil emulsion according to claim 2 or 3, characterized in that: The ozonated oil is a vegetable oil-based ozonated oil, specifically including any one of olive oil-based ozonated oil, sunflower oil-based ozonated oil and sesame oil-based ozonated oil.

5. The antibacterial thermosensitive hand-free hand gel containing a hydrophilic ozone oil emulsion according to claim 3, characterized in that: The ozonated oil is olive oil-based ozonated oil.

6. The antibacterial temperature-sensitive hand-free hand gel containing a hydrophilic ozone oil emulsion according to claim 1, characterized in that: The plant essential oil includes any one of lavender essential oil, tea tree essential oil, rose essential oil and lemon essential oil.

7. A method for preparing an antibacterial thermosensitive hand sanitizer gel containing a hydrophilic ozone oil emulsion as claimed in any one of claims 1 to 6, characterized in that: The following steps are involved: Step 1: Add glycerol and propylene glycol to Carbomer 940 according to weight and stir until the Carbomer 940 is completely soaked to obtain a mixed emulsion; Step 2: Add distilled water to the mixed emulsion prepared in step 1 and heat it under stirring. After the temperature rises to 50-60° C., add benzethonium chloride, phenoxyethanol, 1,2-hexanediol and vitamin E. After stirring until the mixture is completely swollen, stop heating and cool it to room temperature to obtain a gel. Step 3: Add the ozonated oil emulsion to the gel prepared in step 2, stir evenly, then add triethanolamine to adjust to neutrality, add plant essential oil, stir evenly to obtain an antibacterial thermosensitive hand sanitizer gel containing a hydrophilic ozone oil emulsion.

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