Preparation method of methyl p-pentyloxy tribenzoate and anidulafungin side chain

Abstract

The invention discloses a preparation method of methyl p-pentyloxy tribenzoate and anidulafungin side chains, and the preparation method of the methyl p-pentyloxy tribenzoate comprises the following steps: Gomberg-Bachmann reaction: dissolving a first reactant and an acidic solution in a first solvent, adding sodium nitrite or a solution thereof, then adding a second reactant and an alkaline solution, reacting, filtering, washing, and drying to obtain the methyl p-pentyloxy tribenzoate. The methyl p-pentyloxy tribenzoate is obtained; wherein the first reactant is 4-aminobenzoic acid methyl ester, 4-pentyloxy aniline, 4-aminobiphenyl-4-carboxylic acid methyl ester or 4 '-pentyloxy biphenyl-4-amine, and the second reactant is 4-aminobenzoic acid methyl ester or 4'-pentyloxy biphenyl-4-amine; the second reactants are 4-pentyloxy biphenyl, biphenyl-4-methyl formate, pentyloxy benzene or methyl benzoate in sequence in one-to-one correspondence. And carrying out hydrolysis reaction on the prepared methyl p-pentyloxy tribenzoate to obtain the anidulafungin side chain. The prepared anidulafungin side chain is high in purity and low in impurity content, and the preparation method has the advantages of cost and production.

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