Composition for dispelling effects of alcohol and protecting liver and preparation method thereof

Abstract

The invention relates to the technical field of drinking composition preparation, in particular to an alcohol effect dispelling and liver protecting composition and a preparation method thereof.The preparation method comprises the steps that a first raw material is smashed to obtain a first composition; mixing the first composition with a second raw material to obtain a second composition, mixing the second composition with a solvent to form slurry, and freeze-drying the slurry to form granules; and performing a brewing test on the granule so as to analyze the controlled release condition of the granule, and determining whether the addition amount of the lecithin powder is adjusted or not according to the controlled release condition. Through an accurate formula and an intelligent preparation method, effective components in the composition are ensured to be fully released in the brewing process, the addition amount of lecithin powder is optimized according to the controlled release effect, the solubility of particles is improved, the addition amount of lecithin powder is flexibly adjusted according to analysis results of the real-time dissolution rate and the caking area, and the stability of the particles is improved. The consistency of controlled release effects of different batches of products is ensured, and the production efficiency is improved.

Description

Technical Field

[0001] The invention relates to the technical field of preparation of drinking compositions, and in particular to a composition for sobering up and protecting the liver and a preparation method thereof. Background Art

[0002] Hovenia dulcis can clear away heat, promote diuresis, quench thirst, relieve restlessness, and detoxify alcohol. Its mechanism of action is mainly reflected in accelerating ethanol metabolism, shortening the sobering time, and inhibiting ethanol-induced muscle relaxation. Hovenia dulcis extract can significantly reduce ethanol concentration, accelerate ethanol metabolism, and remove excess free radicals produced by drinking, thereby hindering the formation of lipid peroxides. The flavonoids it contains have antioxidant, free radical scavenging, anti-inflammatory, antibacterial, antiviral and clear liver-protecting effects. How to control the release of the active ingredients of the main ingredient and achieve control of the extraction rate of the main ingredient during the brewing process so that it can be used in the preparation of alcohol detoxification compositions has become a topic of increasing concern to relevant researchers.

[0003] China Patent Authorization Announcement No.: CN115671107B discloses a compound pharmaceutical composition for alcohol sobering up, including an opioid receptor antagonist and a heat shock protein agonist, wherein the opioid receptor antagonist is selected from: one or more of naloxone, naltrexone, nalmefene or their pharmaceutical salts; wherein the heat shock protein agonist is selected from: one or more of teprenone, glutamine, rebamipide or their pharmaceutical salts. The invention found that opioid receptor antagonists, in combination with heat shock protein agonists, are used to prevent and treat alcoholism and alcohol dependence syndrome, and have better efficacy, fewer adverse reactions, smaller dosage, better compliance, etc. than opioid receptor antagonists used alone.

[0004] Chinese patent authorization announcement number: CN115737755B discloses a Chinese medicine composition for sobering up, its preparation method and application, and belongs to the field of pharmaceutical technology. The Chinese medicine composition of the present invention is made of the following raw materials in parts by weight: 15-25 parts of Poria cocos, 10-15 parts of Poria cocos, 5-15 parts of Rhizoma Alismatis, 10-20 parts of Rhizoma Atractylodis Macrocephalae, 10-20 parts of Milk Thistle, 10-20 parts of Astragalus, 5-15 parts of Fructus Ligustri Lucidi, 4-8 parts of Lotus Seed Heart, 5-10 parts of Dendrobium, 5-10 parts of Ophiopogon japonicus, 4-8 parts of Plum, 5-10 parts of Lilium, 10-20 parts of Bamboo Leaves, 15-30 parts of Cinnamon Twig, and 10-20 parts of Licorice. The Chinese medicine composition of the present invention is used in the preparation of drugs with sobering up effects; in the preparation of drugs that promote alcohol metabolism or / and relieve discomfort after drinking or / and protect liver damage caused by alcohol or / and relieve symptoms of chronic diseases caused by long-term drinking. The Chinese medicine composition of the present invention has the effects of strengthening the body and eliminating evil, protecting the liver and promoting bile secretion, promoting diuresis and removing dampness, clearing the heart and eliminating vexation, benefiting the stomach and strengthening the spleen, and detoxifying alcohol, and has good safety. The composition can promote alcohol metabolism and relieve various discomfort symptoms caused by drinking.

[0005] However, the above method has the following problems: how to control the release degree and release rate of the active ingredients of the hangover-relieving composition during the brewing process, and then control the extraction rate of the main ingredient during the brewing process, to ensure the stability and continuity of the release of the active ingredients, thereby ensuring the extraction quality; at the same time, no recyclable or degradable packaging materials are used to reduce the impact on the environment. Summary of the invention

[0006] To this end, the present invention provides a hangover-relieving and liver-protecting composition and a preparation method thereof, so as to overcome the problem in the prior art that due to the lack of associated real-time data analysis and image processing, different batches of hangover-relieving compositions have different controlled-release effects, resulting in poor controlled-release effects.

[0007] To achieve the above object, the present invention provides a method for preparing a composition for sobering up and protecting the liver, comprising:

[0008] Step S1, crushing the first raw material until a preset particle size is reached to obtain a first composition, wherein the first raw material includes kudzu root, cassia seed, schisandra chinensis, hovenia dulcis, and mung bean;

[0009] Step S2, mixing the first composition and a second raw material to obtain a second composition, wherein the second raw material comprises corn oligopeptides, lecithin powder, yeast polypeptide, turmeric, mogroside, inulin, sodium carboxymethyl cellulose, vitamin C, vitamin B1, vitamin B2, vitamin B6, iron, zinc, and magnesium;

[0010] Step S3, mixing the second composition with a solvent to form a slurry, and freeze-drying the slurry to form a granule powder;

[0011] Step S4, sampling the granular powder, performing a brewing test under standard brewing conditions to form a brewing solution, continuously capturing images of the brewing solution to obtain a number of actual brewing images, analyzing the controlled release of the granular powder based on the actual brewing images, and determining whether to adjust the amount of lecithin powder added according to the controlled release.

[0012] Furthermore, the controlled release of the granule powder based on the actual brewing image analysis includes:

[0013] Continuously capturing images of the brewing solution at a preset acquisition cycle to obtain a plurality of actual brewing images;

[0014] Scanning each pixel point in each actual brewing image to obtain a corresponding real-time agglomeration contour;

[0015] The real-time dissolution rate is calculated according to the real-time agglomeration profile, and the controlled release of the current batch of granules is analyzed according to the real-time dissolution rate and the real-time agglomeration area, so as to adjust the amount of lecithin powder added according to the controlled release condition.

[0016] Furthermore, each pixel point in each actual brewing image is scanned to obtain a corresponding real-time agglomeration contour, including:

[0017] Scanning each pixel in any of the actual brewing images in sequence, and calculating the real-time brightness difference between two adjacent pixels;

[0018] Compare the preset brightness difference value with the real-time brightness difference value, and determine the contour edge point based on the comparison result;

[0019] A contour curve segment formed by the contour edge points is obtained, brightness weighted processing is performed on an area within the contour curve segment and an area outside the contour curve segment, and the contour curve segment is obtained as a corresponding real-time agglomeration contour.

[0020] Further, performing brightness weighting processing on the area within the contour curve segment and the area outside the contour curve segment includes:

[0021] The brightness value of each pixel point in the area within the contour curve segment is obtained and recorded as the initial brightness value. The average value of each initial brightness value is calculated and recorded as the average foreground brightness. The brightness value of each pixel point in the area outside the contour curve segment is obtained to calculate the average background brightness. The average foreground brightness is subtracted from the average background brightness to obtain the real-time brightness value. Each initial brightness value is added to the real-time brightness difference in turn to obtain the corresponding corrected brightness value. The real-time brightness value in the actual brewing image is corrected to the corrected brightness value, and the brightness value of the contour edge point is corrected to the average background brightness.

[0022] Further, calculating the real-time dissolution rate according to the real-time agglomeration profile includes,

[0023] Obtaining real-time agglomeration contours corresponding to two adjacent actual brewing images;

[0024] Calculating the difference between the perimeter area ratios corresponding to the two real-time agglomeration contours to obtain a perimeter area ratio difference;

[0025] The ratio of the perimeter area ratio difference to the shooting time interval is calculated to obtain the real-time dissolution rate;

[0026] The perimeter-to-area ratio is the ratio of the perimeter to the area of ​​the real-time agglomeration contour.

[0027] Further, the controlled release of the current batch of granules is analyzed based on the real-time dissolution rate and the real-time agglomeration area, including:

[0028] Comparing the standard dissolution rate with the real-time dissolution rate, and determining whether to adjust the amount of lecithin powder added to the next batch by a preset increase amount based on the comparison result;

[0029] When the real-time dissolution rate is greater than the standard dissolution rate, the area of ​​any real-time agglomeration contour is obtained to obtain the real-time agglomeration area, the standard agglomeration area and the real-time agglomeration area are compared to draw a real-time rate fitting curve, and a controlled release rate change curve is obtained based on the real-time rate fitting curve;

[0030] The controlled release rate change curve is analyzed, and the dissolution time is obtained based on the analysis result, or it is determined whether to adjust the amount of lecithin powder added based on the current dissolution time.

[0031] Furthermore, the process of obtaining the controlled release rate change curve based on the real-time rate fitting curve is as follows:

[0032] The maximum slope of the real-time rate fitting curve is taken as the real-time change rate, the real-time change rate of each preset collection cycle is obtained, and a curve of the real-time change rate versus time is plotted to obtain a controlled release rate change curve.

[0033] Further, the controlled release rate change curve is analyzed including:

[0034] If a peak appears in the controlled release rate change curve, the time corresponding to the peak point is obtained to obtain the dissolution time;

[0035] If no peak appears in the controlled release rate change curve, the current dissolution time is analyzed, and it is determined whether to adjust the amount of lecithin powder added based on the current dissolution time.

[0036] Further, determining whether to adjust the amount of lecithin powder added based on the current dissolution time includes,

[0037] Compare the standard dissolve time with the current dissolve time:

[0038] If the current dissolution time is less than the standard dissolution time, it is determined that the controlled release of the current batch of granules is normal, and the controlled release rate change curve is continued to be analyzed;

[0039] If the current dissolution time is greater than or equal to the standard dissolution time, it is determined that the controlled release of the current batch of granules is abnormal, and the amount of lecithin powder added to the next batch is adjusted by a preset increase;

[0040] The preset increase amount is 20% of the addition amount of the lecithin powder of the current batch.

[0041] Furthermore, the weight proportions of the raw materials of the alcohol-relief and liver-protection composition are:

[0042] 2-4 parts of Pueraria root, 3-5 parts of Cassia seed, 3-5 parts of Schisandra chinensis, 2-4 parts of Hovenia dulcis, 6-10 parts of Mung bean, 0.5-1.5 parts of corn oligopeptides, 1-2.5 parts of lecithin powder, 0.5-1.5 parts of yeast polypeptide, 0.8-1.5 parts of turmeric, 0.8-1.7 parts of mogroside, 0.5-1.5 parts of inulin, 0.8-1.7 parts of sodium carboxymethyl cellulose, 0.003 parts of vitamin C, 0.003 parts of vitamin B1, 0.003 parts of vitamin B2, 0.003 parts of vitamin B6, 0.001 parts of iron, 0.001 parts of zinc, and 0.001 parts of magnesium.

[0043] Compared with the prior art, the beneficial effects of the present invention are that, through precise formula and intelligent preparation method, the effective ingredients in the composition are ensured to be fully released during the brewing process, the addition amount of lecithin powder is optimized according to the controlled release effect, the solubility of the particles is improved, and the addition amount of lecithin powder is flexibly adjusted according to the analysis results of the real-time dissolution rate and agglomeration area, so as to ensure the consistency of the controlled release effect of different batches of products and improve the production efficiency.

[0044] Furthermore, the controlled release of the granular powder is analyzed through brewing tests, and the contour characteristics of the agglomerates in the powder are obtained by combining image recognition technology, so as to intelligently analyze the brewing effect and improve the accuracy of the analysis.

[0045] Furthermore, by calculating and comparing the real-time brightness difference of each pixel in the actual brewing image, the boundaries of the agglomerated particles are accurately identified, and through brightness weighted processing, the quality of the contour curve segment is effectively improved, so that the final real-time agglomeration contour is clearer and smoother, thereby improving the accuracy of particle recognition.

[0046] Furthermore, when the dissolution rate is relatively high, the real-time agglomeration area is analyzed. If the real-time agglomeration area is smaller than the standard agglomeration area, it indicates that the dissolution rate is too fast. The sustained-release effect can be achieved by reducing the amount of lecithin powder added. If the real-time agglomeration area is larger than the standard agglomeration area, it indicates that the dissolution rate is relatively fast and meets the standard. As the brewing time continues, the number of dissolved particles gradually increases. When the particles are nearly completely dissolved, the controlled-release rate no longer increases, and a downward trend is shown until it flattens out. The controlled-release effect within the preset collection period is monitored, that is, the time for complete dissolution of the particles is determined to analyze whether the controlled-release situation is normal. The method is simple and effective. BRIEF DESCRIPTION OF THE DRAWINGS

[0047] Figure 1 The figure is a schematic flow chart of a method for preparing a composition for sobering up and protecting the liver according to an embodiment of the present invention;

[0048] Figure 2 The schematic diagram is a flow chart of analyzing the controlled release of granules in an embodiment of the present invention;

[0049] Figure 3 A schematic diagram of a process for obtaining a corresponding real-time agglomeration profile according to an embodiment of the present invention;

[0050] Figure 4 Schematic diagram of the process of calculating the real-time dissolution rate according to an embodiment of the present invention. DETAILED DESCRIPTION

[0051] In order to make the objects and advantages of the present invention more clearly understood, the present invention is further described below in conjunction with embodiments; it should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0052] The preferred embodiments of the present invention are described below with reference to the accompanying drawings. It should be understood by those skilled in the art that these embodiments are only used to explain the technical principles of the present invention and are not intended to limit the protection scope of the present invention.

[0053] It should be noted that, in the description of the present invention, terms such as "up", "down", "left", "right", "inside" and "outside" indicating directions or positional relationships are based on the directions or positional relationships shown in the drawings. This is merely for the convenience of description and does not indicate or imply that the device or element must have a specific orientation, be constructed and operated in a specific orientation. Therefore, it cannot be understood as a limitation on the present invention.

[0054] In addition, it should be noted that in the description of the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For those skilled in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0055] See also Figure 1 As shown, it is a schematic flow diagram of a method for preparing a hangover-relieving composition according to an embodiment of the present invention. The present invention provides a method for preparing a hangover-relieving and liver-protecting composition, comprising:

[0056] Step S1, crushing the first raw material until a preset particle size is reached to obtain a first composition, wherein the first raw material includes kudzu root, cassia seed, schisandra chinensis, hovenia dulcis, and mung bean;

[0057] Step S2, mixing the first composition and a second raw material to obtain a second composition, wherein the second raw material comprises corn oligopeptides, lecithin powder, yeast polypeptide, turmeric, mogroside, inulin, sodium carboxymethyl cellulose, vitamin C, vitamin B1, vitamin B2, vitamin B6, iron, zinc, and magnesium;

[0058] Step S3, mixing the second composition with a solvent to form a slurry, and freeze-drying the slurry to form a granule powder;

[0059] Step S4, sampling the granule instant preparation, performing a brewing test under standard brewing conditions to obtain a brewing solution, and recording the dissolution time, continuously shooting images of the brewing solution to obtain a plurality of actual brewing images, analyzing the controlled release of the granule instant preparation based on the actual brewing images, and determining whether to adjust the amount of lecithin powder added according to the controlled release;

[0060] The granule powder is sampled, and a brewing test is performed under standard brewing conditions to obtain a brewing solution, and the dissolution time is recorded;

[0061] In this embodiment, the weight of each component is accurately weighed according to the formula requirements, and then the solid component is crushed and mixed evenly with the powdered component. A slurry is formed by adding an appropriate amount of solvent water, and the amount of solvent added is 1 / 3 of the total weight of the formula; a dry granulation process is used to prepare the granules, the extrusion pressure is 15Mpa-25Mpa, the extrusion speed is 8r / min, and the feeding speed is 10r / min; the standard brewing condition is to put the granules into water at a temperature of 60°C and stir; the granules are packaged, and recyclable or degradable packaging materials are used to reduce carbon footprint, and a mixture of carbon dioxide and nitrogen is used to replace oxygen in the packaging bag to extend the shelf life and prevent moisture and caking.

[0062] Through precise formula and intelligent preparation method, the effective ingredients in the composition are ensured to be fully released during the brewing process. The amount of lecithin powder added is optimized according to the controlled-release effect to improve the solubility of the particles. According to the analysis results of real-time dissolution rate and agglomeration area, the amount of lecithin powder added is flexibly adjusted to ensure the consistency of the controlled-release effect of different batches of products and improve production efficiency.

[0063] See also Figure 2 As shown, it is a schematic diagram of the process of analyzing the controlled release of granule granules according to an embodiment of the present invention;

[0064] Specifically, the controlled release of granules based on actual brewing images includes:

[0065] Step S4001, continuously photographing the brewing solution at a preset acquisition cycle to obtain a plurality of actual brewing images;

[0066] Step S4002, scanning each pixel point in each actual brewing image to obtain a corresponding real-time agglomeration contour;

[0067] Step S4003, calculating the real-time dissolution rate according to the real-time agglomeration profile, analyzing the controlled release of the current batch of granules according to the real-time dissolution rate and the real-time agglomeration area, and adjusting the amount of lecithin powder added according to the controlled release.

[0068] The controlled release of granular powder is analyzed through brewing tests, and the contour characteristics of agglomerates in the powder are obtained by combining image recognition technology, so as to intelligently analyze the brewing effect and improve the accuracy of the analysis.

[0069] See also Figure 3 As shown, it is a schematic diagram of a process of obtaining a corresponding real-time agglomeration profile according to an embodiment of the present invention;

[0070] Specifically, each pixel point in each actual brewing image is scanned to obtain a corresponding real-time agglomeration contour, including:

[0071] Step S4011, scanning each pixel in any of the actual brewing images in sequence, and calculating the real-time brightness difference between two adjacent pixels;

[0072] Step S4021, comparing the preset brightness difference value with the real-time brightness difference value, and determining the contour edge point based on the comparison result;

[0073] Step S4031, obtaining a contour curve segment formed by the contour edge points, performing brightness weighting processing on the area inside the contour curve segment and the area outside the contour curve segment, and obtaining the contour curve segment as the corresponding real-time agglomeration contour.

[0074] By calculating and comparing the real-time brightness difference of each pixel in the actual brewing image, the boundaries of the agglomerated particles can be accurately identified. Through brightness weighted processing, the quality of the contour curve segment is effectively improved, making the final real-time agglomeration contour clearer and smoother, thereby improving the accuracy of particle recognition.

[0075] Specifically, determining the contour edge points based on the comparison results includes:

[0076] When the real-time brightness difference is greater than or equal to the preset brightness difference, two adjacent pixels are marked as contour points;

[0077] When the real-time brightness difference is less than the preset brightness difference, no contour point marking is performed on two adjacent pixel points;

[0078] Until the scanning and determination of the actual brewing image is completed, each pixel point that has completed the contour point marking is obtained and recorded as a contour edge point.

[0079] The preset brightness difference value set in this embodiment is a brightness difference threshold between agglomerate particles and solution in an actual brewing image, and the preset brightness difference value is set to 30.

[0080] By comparing the preset brightness difference with the real-time brightness difference, the edge of the agglomerated particle area image is intelligently determined. By calculating the brightness difference between each pixel and its adjacent pixels, the pixels with obvious brightness changes are marked as contour points to ultimately form the boundary of the agglomerated particles. The method is simple and effective.

[0081] Specifically, the brightness weighted processing of the area within the contour curve segment and the area outside the contour curve segment includes:

[0082] The brightness value of each pixel point in the area within the contour curve segment is obtained and recorded as the initial brightness value. The average value of each initial brightness value is calculated and recorded as the average foreground brightness. The brightness value of each pixel point in the area outside the contour curve segment is obtained to calculate the average background brightness. The average foreground brightness is subtracted from the average background brightness to obtain the real-time brightness value. Each initial brightness value is added to the real-time brightness difference in turn to obtain the corresponding corrected brightness value. The real-time brightness value in the actual brewing image is corrected to the corrected brightness value, and the brightness value of the contour edge point is corrected to the average background brightness.

[0083] By performing weighted average calculation on the brightness values ​​of the pixels, the data can be analyzed accurately and reliably, and the brightness values ​​of the pixels in the inner contour area can be increased to enhance the contrast between the inner contour area and the outer contour area, so that the agglomerated particle area and the solution area can be effectively separated, thereby increasing the accuracy of identifying the agglomerated particle area and facilitating the calculation of the area.

[0084] See also Figure 4 As shown, it is a schematic diagram of the process of calculating the real-time dissolution rate according to an embodiment of the present invention;

[0085] Specifically, calculating the real-time dissolution rate according to the real-time agglomeration profile includes:

[0086] Step S4013, obtaining real-time agglomeration contours corresponding to two adjacent actual brewing images;

[0087] Step S4023, calculating the difference between the perimeter area ratios corresponding to the two real-time agglomeration contours to obtain a perimeter area ratio difference;

[0088] Step S4033, calculating the ratio of the perimeter area ratio difference to the shooting time interval to obtain the real-time dissolution rate;

[0089] The perimeter-to-area ratio is the ratio of the perimeter to the area of ​​the real-time agglomeration contour.

[0090] The shooting time interval in this embodiment is the length of time for collecting two actual brewing images, and the shooting time interval is 1s; the perimeter area ratio represents the size of the real-time agglomeration contour, the calculated perimeter area ratio difference represents the degree of change of the real-time agglomeration contour, and the real-time dissolution rate represents the rate of change of the real-time agglomeration contour.

[0091] Specifically, the controlled release of the current batch of granules is analyzed based on the real-time dissolution rate and real-time agglomeration area, including:

[0092] Compare the standard dissolution rate to the real-time dissolution rate:

[0093] If the real-time dissolution rate is less than or equal to the standard dissolution rate, the continuous images taken in the next preset acquisition cycle are analyzed; if the real-time dissolution rate is still determined to be less than or equal to the standard dissolution rate, the controlled release effect is determined to be unqualified, and the current brewing test operation is completed, and the addition amount of the next batch of lecithin powder is adjusted by the preset increase amount;

[0094] The preset increase amount is 20% of the amount of lecithin powder added in the current batch;

[0095] If the real-time dissolution rate is greater than the standard dissolution rate, obtain the area of ​​any real-time agglomeration contour, obtain the real-time agglomeration area, and compare the standard agglomeration area with the real-time agglomeration area:

[0096] If the real-time agglomeration area is smaller than the standard agglomeration area, the controlled release effect is determined to be unqualified, and the current brewing test operation is completed, and the amount of lecithin powder added in the next batch is adjusted by a preset reduction amount;

[0097] The preset reduction amount is 10% of the added amount of the current batch of lecithin powder;

[0098] If the real-time agglomeration area is larger than the standard agglomeration area, a real-time dissolution rate variation curve is plotted with a preset collection time, and a linear fit is performed to obtain a real-time rate fitting curve. The maximum slope of the real-time rate fitting curve is used as the real-time change rate, and the real-time change rate of each preset collection cycle is obtained. A real-time change rate variation curve with time is plotted to obtain a controlled release rate change curve, and the controlled release rate change curve is analyzed:

[0099] If a peak appears in the controlled release rate change curve, the time corresponding to the peak point is obtained to obtain the dissolution time;

[0100] If no peak appears in the controlled release rate change curve, the current dissolution time is analyzed, and it is determined whether to adjust the amount of lecithin powder added based on the current dissolution time.

[0101] The standard agglomeration area in this embodiment represents the parameter value corresponding to when the particles are completely dissolved, and the set value approaches zero. When the dissolution rate is relatively high, the real-time agglomeration area is analyzed. If the real-time agglomeration area is smaller than the standard agglomeration area, it indicates that the dissolution rate is too fast. The sustained-release effect can be achieved by reducing the amount of lecithin powder added. If the real-time agglomeration area is larger than the standard agglomeration area, it indicates that the dissolution rate is relatively fast and meets the standard. As the brewing time continues, the dissolved particles gradually increase. When the particles are nearly completely dissolved, the controlled-release rate no longer increases, and a downward trend appears until it is flat. The controlled-release effect within the preset collection period is monitored, that is, the time for the particles to be completely dissolved is determined to analyze whether the controlled-release situation is normal. The method is simple and effective.

[0102] Specifically, determining whether to adjust the amount of lecithin powder added based on the current dissolution time includes:

[0103] Compare the standard dissolve time with the current dissolve time:

[0104] If the current dissolution time is less than the standard dissolution time, it is determined that the controlled release of the current batch of granules is normal, and the controlled release rate change curve is continued to be analyzed;

[0105] If the current dissolution time is greater than or equal to the standard dissolution time, it is determined that the controlled release of the current batch of granules is abnormal, and the amount of lecithin powder added to the next batch is adjusted by a preset increase;

[0106] The preset increase amount is 20% of the addition amount of the lecithin powder of the current batch.

[0107] The standard dissolution time set in this embodiment represents the expected time for the particles to be completely dissolved in order to achieve the expected controlled release effect. The standard dissolution time can be set to 300 seconds or any desired ideal time.

[0108] By increasing the amount of lecithin powder added, the dissolution rate is improved to ensure the quality and effect of the product.

[0109] Specifically, the raw materials of the alcohol-relief and liver-protection composition are as follows:

[0110] 2-4 parts of Pueraria root, 3-5 parts of Cassia seed, 3-5 parts of Schisandra chinensis, 2-4 parts of Hovenia dulcis, 6-10 parts of Mung bean, 0.5-1.5 parts of corn oligopeptides, 1-2.5 parts of lecithin powder, 0.5-1.5 parts of yeast polypeptide, 0.8-1.5 parts of turmeric, 0.8-1.7 parts of mogroside, 0.5-1.5 parts of inulin, 0.8-1.7 parts of sodium carboxymethyl cellulose, 0.003 parts of vitamin C, 0.003 parts of vitamin B1, 0.003 parts of vitamin B2, 0.003 parts of vitamin B6, 0.001 parts of iron, 0.001 parts of zinc, and 0.001 parts of magnesium.

[0111] Pueraria root is the dried root of the leguminous plant Pueraria lobata. Its main components are isoflavone compounds such as puerarin and daidzein. It is a traditional Chinese medicine for relieving alcohol.

[0112] Cassia seed is the dried mature seed of the leguminous plants Cassia or Cassia sibiricum, which mainly contains anthraquinone compounds and is a traditional liver-protecting food.

[0113] Schisandra chinensis is the dried mature fruit of the Magnoliaceae plant Schisandra chinensis or Schisandra sphenanthera, and its main component is lignan compounds. "Rihuazi Materia Medica" records that it can quench thirst, eliminate irritability and heat, detoxify alcohol, and strengthen muscles and bones.

[0114] Corn oligopeptides can activate ADH activity in vitro and reduce the blood ethanol concentration of mice. At the same time, the scavenging ability of corn oligopeptides on OH has a synergistic effect on antioxidants. Corn oligopeptides can significantly increase the content of leucine and alanine in plasma, reduce the blood ethanol concentration in drinkers, and thus promote alcohol metabolism.

[0115] Mung beans are rich in water and dietary fiber, which can promote the production of urine, help the body excrete excess water and toxins, thereby accelerating the excretion of alcohol. The flavonoids in mung beans have antioxidant effects, which can protect liver cells and reduce the damage of alcohol to the liver. Mung beans have the effect of clearing heat and detoxifying, helping the body excrete toxins produced during alcohol metabolism and reducing the burden of alcohol on the liver.

[0116] Hovenia dulcis contains antioxidant ingredients that can protect liver cells, reduce alcohol damage to the liver, and also has the effects of clearing heat, detoxifying and acting as a diuretic.

[0117] The main component of alcohol is ethanol. After entering the human body, it first undergoes first-pass metabolism (FPM) in the stomach. ADH on the gastric mucosa can catalyze the oxidation of ethanol to acetaldehyde, which is then oxidized to acetic acid by ALDH. 90% of the ethanol that passes through the stomach is metabolized in the liver. Its main metabolic pathway is through the alcohol dehydrogenase system located in the mitochondria. The acetic acid formed is then metabolized to H through the tricarboxylic acid cycle. 2 O and CO 2 In the process of ethanol dehydrogenation to form acetaldehyde and acetic acid, oxidized coenzyme I (NAD+) is converted into reduced coenzyme I (NADH); the reduction of blood ethanol concentration depends on the enhancement of alcohol dehydrogenase activity in the liver; therefore, the alcohol-relieving and liver-protecting granules can theoretically enhance the first-pass effect of ethanol in the gastrointestinal tract, and can also directly act on the liver metabolic enzyme system, accelerate the metabolic rate of ethanol and its metabolites, reduce the concentration of ethanol in the blood, and reduce damage to cell tissues.

[0118] Specifically, the alcohol sobering and liver protecting composition of the present invention was given to a test group for testing, and the test method, test data, and test results are as follows:

[0119] The exclusion criteria for the trial population were cardiovascular and renal dysfunction, hematopoietic system diseases, mental and cognitive disorders, use of hormonal drugs, allergies to the components of the composition of this embodiment, withdrawal from the study, and inability to cooperate to complete the study; the subjects were aged between 18 and 60 years old, and the trial was randomly divided into two groups, a control group and a test group, with 30 people in each group.

[0120] All subjects drank alcohol in moderation, and the experimental group took the hangover-relief composition 30 minutes before and after drinking, 30 g each time, and mixed it with warm water. The control group did not take any hangover-relief product.

[0121] Before the start of the experiment, each subject's blood alcohol concentration, liver function indicators (such as ALT, AST), and self-perception (such as headache, nausea, etc.) were recorded; the experiment ended 30 minutes after taking the hangover composition. After the experiment, the test indicators of each subject, including the above characteristics, were recorded; finally, a subject satisfaction survey was conducted, and any adverse reactions such as headache, nausea, and fatigue were monitored during the experiment.

[0122] The experimental results are shown in Table 1 and Table 2, wherein Table 1 is a comparison of test indicators and results of the embodiments of the present invention, and Table 2 is a comparison of adverse reactions and results of the embodiments of the present invention;

[0123] Table 1 Comparison of detection indicators between the two groups

[0124]

[0125] Table 2 Comparison of adverse reactions between the two groups

[0126]

[0127] The hangover-relieving composition prepared in this example achieves the hangover-relieving effect by reducing the blood alcohol concentration, liver function indexes, etc. of the subject, and provides experimental data that can confirm that the above-mentioned hangover-relieving composition formula can achieve the hangover-relieving effect by promoting alcohol metabolism and protecting the liver.

[0128] So far, the technical solutions of the present invention have been described in conjunction with the preferred embodiments shown in the accompanying drawings. However, it is easy for those skilled in the art to understand that the protection scope of the present invention is obviously not limited to these specific embodiments. Without departing from the principle of the present invention, those skilled in the art can make equivalent changes or substitutions to the relevant technical features, and the technical solutions after these changes or substitutions will fall within the protection scope of the present invention.

[0129] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A method for preparing a composition for sobering up and protecting the liver, characterized in that: include: Step S1, crushing the first raw material until a preset particle size is reached to obtain a first composition, wherein the first raw material includes kudzu root, cassia seed, schisandra chinensis, hovenia dulcis, and mung bean; Step S2, mixing the first composition and a second raw material to obtain a second composition, wherein the second raw material comprises corn oligopeptides, lecithin powder, yeast polypeptide, turmeric, mogroside, inulin, sodium carboxymethyl cellulose, vitamin C, vitamin B1, vitamin B2, vitamin B6, iron, zinc, and magnesium; Step S3, mixing the second composition with a solvent to form a slurry, and freeze-drying the slurry to form a granule powder; Step S4, sampling the granular powder, performing a brewing test under standard brewing conditions to form a brewing solution, continuously capturing images of the brewing solution to obtain a number of actual brewing images, analyzing the controlled release of the granular powder based on the actual brewing images, and determining whether to adjust the amount of lecithin powder added according to the controlled release.

2. The method for preparing the alcohol-relief and liver-protection composition according to claim 1, characterized in that: The controlled release of granules based on actual brewing images includes: Continuously capturing images of the brewing solution at a preset acquisition cycle to obtain a plurality of actual brewing images; Scanning each pixel point in each actual brewing image to obtain a corresponding real-time agglomeration contour; The real-time dissolution rate is calculated according to the real-time agglomeration profile, and the controlled release of the current batch of granules is analyzed according to the real-time dissolution rate and the real-time agglomeration area, so as to adjust the amount of lecithin powder added according to the controlled release condition.

3. The method for preparing the alcohol-relief and liver-protection composition according to claim 2, characterized in that: Scanning each pixel point in each actual brewing image to obtain the corresponding real-time agglomeration contour includes: Scanning each pixel in any of the actual brewing images in sequence, and calculating the real-time brightness difference between two adjacent pixels; Compare the preset brightness difference value with the real-time brightness difference value, and determine the contour edge point based on the comparison result; A contour curve segment formed by the contour edge points is obtained, brightness weighted processing is performed on an area within the contour curve segment and an area outside the contour curve segment, and the contour curve segment is obtained as a corresponding real-time agglomeration contour.

4. The method for preparing the alcohol-relief and liver-protection composition according to claim 3, characterized in that: The brightness weighted processing of the area within the contour curve segment and the area outside the contour curve segment includes: The brightness value of each pixel point in the area within the contour curve segment is obtained and recorded as the initial brightness value. The average value of each initial brightness value is calculated and recorded as the average foreground brightness. The brightness value of each pixel point in the area outside the contour curve segment is obtained to calculate the average background brightness. The average foreground brightness is subtracted from the average background brightness to obtain the real-time brightness value. Each initial brightness value is added to the real-time brightness difference in turn to obtain the corresponding corrected brightness value. The real-time brightness value in the actual brewing image is corrected to the corrected brightness value, and the brightness value of the contour edge point is corrected to the average background brightness.

5. The method for preparing the alcohol-relief and liver-protection composition according to claim 2, characterized in that: Calculating the real-time dissolution rate according to the real-time agglomeration profile comprises, Obtaining real-time agglomeration contours corresponding to two adjacent actual brewing images; Calculating the difference between the perimeter area ratios corresponding to the two real-time agglomeration contours to obtain a perimeter area ratio difference; The ratio of the perimeter area ratio difference to the shooting time interval is calculated to obtain the real-time dissolution rate; The perimeter-to-area ratio is the ratio of the perimeter to the area of ​​the real-time agglomeration contour.

6. The method for preparing the alcohol-relief and liver-protection composition according to claim 5, characterized in that: The controlled release of the current batch of granules is analyzed based on the real-time dissolution rate and real-time agglomeration area, including: Comparing the standard dissolution rate with the real-time dissolution rate, and determining whether to adjust the amount of lecithin powder added to the next batch by a preset increase amount based on the comparison result; When the real-time dissolution rate is greater than the standard dissolution rate, the area of ​​any real-time agglomeration contour is obtained to obtain the real-time agglomeration area, the standard agglomeration area and the real-time agglomeration area are compared to draw a real-time rate fitting curve, and a controlled release rate change curve is obtained based on the real-time rate fitting curve; The controlled release rate change curve is analyzed, and the dissolution time is obtained based on the analysis result, or it is determined whether to adjust the amount of lecithin powder added based on the current dissolution time.

7. The method for preparing the alcohol-relief and liver-protection composition according to claim 6, characterized in that: The process of obtaining the controlled release rate change curve based on the real-time rate fitting curve is as follows: The maximum slope of the real-time rate fitting curve is taken as the real-time change rate, the real-time change rate of each preset collection cycle is obtained, and a curve of the real-time change rate versus time is plotted to obtain a controlled release rate change curve.

8. The method for preparing the alcohol-relief and liver-protection composition according to claim 7, characterized in that: Analysis of the controlled release rate change curve includes: If a peak appears in the controlled release rate change curve, the time corresponding to the peak point is obtained to obtain the dissolution time; If no peak appears in the controlled release rate change curve, the current dissolution time is analyzed, and it is determined whether to adjust the amount of lecithin powder added based on the current dissolution time.

9. The method for preparing the alcohol-relief and liver-protection composition according to claim 8, characterized in that: Determining whether to adjust the amount of lecithin powder added based on the current dissolution time includes: Compare the standard dissolve time to the current dissolve time: If the current dissolution time is less than the standard dissolution time, the controlled release of the current batch of granules is determined to be normal, and the controlled release rate change curve is continued to be analyzed; If the current dissolution time is greater than or equal to the standard dissolution time, it is determined that the controlled release of the current batch of granules is abnormal, and the amount of lecithin powder added to the next batch is adjusted by a preset increase; The preset increase amount is 20% of the addition amount of the lecithin powder of the current batch.

10. The method for preparing the alcohol sobering and liver protecting composition according to claim 1, characterized in that: The raw materials of the alcohol-relief and liver-protection composition are as follows: 2-4 parts of Pueraria root, 3-5 parts of Cassia seed, 3-5 parts of Schisandra chinensis, 2-4 parts of Hovenia dulcis, 6-10 parts of Mung bean, 0.5-1.5 parts of corn oligopeptide, 1-2.5 parts of lecithin powder, 0.5-1.5 parts of yeast polypeptide, 0.8-1.5 parts of turmeric, 0.8-1.7 parts of mogroside, 0.5-1.5 parts of inulin, 0.8-1.7 parts of sodium carboxymethyl cellulose, 0.003 parts of vitamin C, 0.003 parts of vitamin B1, 0.003 parts of vitamin B2, 0.003 parts of vitamin B6, 0.001 parts of iron, 0.001 parts of zinc, and 0.001 parts of magnesium.

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