Donor perfusion device and method of use thereof

Abstract

The invention discloses a donor perfusion device and a use method thereof, and belongs to the field of organ transplantation. The donor perfusion device comprises a control host, a blood storage device, a processing assembly and a pump driving assembly, the blood storage device is used for receiving blood input by a donor; the blood is output to the donor after passing through the processing assembly; the pump driving assembly is communicated with the blood storage device and the processing assembly to drive blood to flow through the processing assembly and then to be output, the pump driving assembly comprises a first pump body and a second pump body, and the first pump body and the second pump body are in communication connection with the control host; wherein the pump driving assembly has a first working condition and a second working condition, under the first working condition, the control host controls the first pump body to work, and under the second working condition, the control host controls the second pump body to work. According to the donor perfusion device, when the first pump body breaks down, the second pump body can be started to serve as a standby driving source, so that driving of blood circulation continues to be completed, and the long-time ischemia phenomenon of a donor is avoided.

Description

Technical Field

[0001] The present invention relates to the field of organ transplantation, and in particular to a donor perfusion device and a use method thereof. Background Art

[0002] Organ transplantation technology replaces organs that have lost their function due to disease or injury by transplanting healthy human organs into patients in need. From early kidney transplantation and liver transplantation to current lung transplantation and heart transplantation, the scope of organ transplantation has been continuously expanded and the technology has become increasingly mature.

[0003] In related technologies, organ transplantation often involves the ex vivo transport of organs, which requires the use of a donor perfusion device to simulate the environment of the organ in the human body, so as to maintain the activity of the organ. The donor perfusion device is often equipped with a blood pump to drive blood circulation. However, if the blood pump fails during the organ transport or transplantation process, it will seriously affect the activity of the organ and even cause organ death. Summary of the invention

[0004] The present invention aims to solve at least one of the technical problems existing in the prior art. To this end, the present invention provides a donor perfusion device, which can start a second pump body as a backup driving source when a first pump body fails, thereby continuing to drive blood circulation to avoid prolonged ischemia of the donor.

[0005] The present invention also provides a method for using the donor perfusion device applied to the donor perfusion device.

[0006] The donor perfusion device according to the first aspect of the present invention comprises:

[0007] Control host;

[0008] A blood reservoir, the blood reservoir is used to receive blood transfused from a donor;

[0009] A processing component, the processing component is in communication with the blood reservoir, and the blood is output to the donor after passing through the processing component;

[0010] A pump drive assembly, the pump drive assembly is respectively connected to the blood reservoir and the processing assembly to drive the blood to flow through the processing assembly and then output, the pump drive assembly includes a first pump body and a second pump body, the first pump body and the second pump body are respectively connected to the control host for communication;

[0011] Wherein, the pump drive assembly has a first working condition and a second working condition. In the first working condition, the control host controls the first pump body to work, and in the second working condition, the control host controls the second pump body to work.

[0012] The donor perfusion device according to the embodiment of the present invention has at least the following beneficial effects:

[0013] When the first pump body of the donor perfusion device of the present application fails, the second pump body can be started as a backup drive source to continue driving the blood circulation to avoid prolonged ischemia of the donor. The donor perfusion device is more suitable for long-term organ transportation scenarios. The redundant design of the pump drive component ensures the stable operation of the donor perfusion device in complex situations and improves the reliability of the donor perfusion device.

[0014] According to some embodiments of the present invention, the donor perfusion device includes an output pipeline, one end of which is connected to the processing component, and the other end is used to communicate with the donor, the output pipeline is provided with a sensor that is communicatively connected to the control host, the control host obtains the physiological parameters collected by the sensor, and if the physiological parameters are out of a set range, the control host controls the pump drive component to switch from the first working condition to the second working condition;

[0015] Alternatively, the control host obtains the working parameters of the first pump body, and if the working parameters are outside a set range, the control host controls the pump drive component to switch from the first working condition to the second working condition.

[0016] According to some embodiments of the present invention, after the control host switches from the first operating condition to the second operating condition, the current operating condition is set as the first operating condition, the second pump body is set as the new first pump body, and the first pump body is set as the new second pump body.

[0017] According to some embodiments of the present invention, the pump drive assembly includes a first pump head that can be detachably connected to either the first pump body or the second pump body, and the first pump body and the second pump body can both drive the first pump head to operate. The first pump head is respectively connected to the blood reservoir and the processing assembly. Under the first operating condition, the first pump head is connected to the first pump body, and under the second operating condition, the first pump head is connected to the second pump body.

[0018] According to some embodiments of the present invention, the pump drive assembly includes a first pump head connected to the first pump body, and the first pump head is respectively connected to the blood reservoir and the processing assembly. The pump drive assembly also includes a second pump head connected to the second pump body, and the second pump head is respectively connected to the blood reservoir and the processing assembly. Under the first operating condition, the blood reservoir, the first pump head and the processing assembly form a passage, and under the second operating condition, the blood reservoir, the second pump head and the processing assembly form a passage.

[0019] According to some embodiments of the present invention, the pump drive assembly further comprises an input three-way valve and an output three-way valve, each port of the input three-way valve is respectively connected to the blood reservoir, the input port of the first pump head and the input port of the second pump head, and each port of the output three-way valve is respectively connected to the processing assembly, the output port of the first pump head and the output port of the second pump head;

[0020] Among them, the input three-way valve and the output three-way valve are respectively connected to the control host for communication, and are switched on and off under the control of the control host. Under the first working condition, the blood reservoir, the input port of the first pump head, the output port of the first pump head and the processing component are connected in sequence; under the second working condition, the blood reservoir, the input port of the second pump head, the output port of the second pump head and the processing component are connected in sequence.

[0021] According to some embodiments of the present invention, the donor perfusion device includes an input pipe connected to the blood reservoir and an output pipe connected to the processing component, and the donor perfusion device includes a self-circulation mode and an external circulation mode. In the self-circulation mode, the input pipe is connected to the output pipe, and in the external circulation mode, the input pipe is used to communicate with the donor, and the output pipe is used to communicate with the donor;

[0022] The donor perfusion device switches to the external circulation mode after executing the self-circulation mode for a set time, wherein in the self-circulation mode, the control host controls the pump drive component to switch the working condition at least once.

[0023] According to some embodiments of the present invention, the donor perfusion device comprises an input conduit in communication with the blood reservoir and an output conduit in communication with the processing assembly, the output conduit being used to communicate with the donor;

[0024] Wherein, the donor perfusion device also includes a circulation pipeline, one end of which is connected to the blood reservoir, and the other end is connected to the processing component. When the output pipeline and the input pipeline are ready to be connected to the donor, at least the output pipeline is closed and the circulation pipeline is opened. After the output pipeline is connected to the donor, the circulation pipeline is closed.

[0025] According to some embodiments of the present invention, the donor perfusion device also includes a trolley, the trolley is provided with a mounting table, the mounting table is provided with a snap-on assembly, and the opposite side walls of the control host are respectively provided with snap-on grooves, and when the control host is placed on the mounting table, the snap-on assembly is snap-on with the snap-on grooves.

[0026] According to some embodiments of the present invention, the mounting platform includes a first shell and a second shell, the first shell and the second shell define a transmission cavity, the mounting platform also includes a clamping member, an elastic member, a conversion member, and a key movably connected to the first shell and arranged in the transmission cavity, the elastic member is connected to the clamping member, and the clamping member and the conversion member are rotatably connected to the second shell respectively;

[0027] In which, the clamping member has a first state in which it is driven by the elastic member and partially protrudes from the first shell. In the first state, the protruding part of the clamping member can be embedded in the clamping groove to limit the movement of the control host; and the clamping member also has a second state in which it is driven by the adapter and retracted to the first shell. In the second state, the clamping member is located outside the clamping groove, and the control host can be separated from the mounting platform; the button is configured to: drive the adapter to rotate when pressed, so as to drive the clamping member to switch from the first state to the second state.

[0028] According to some embodiments of the present invention, the trolley is further provided with a mounting rod and a mounting bracket arranged on the mounting rod, the mounting bracket includes a first main body portion sleeved on the mounting rod, a second main body portion rotatably connected to the first main body portion, a first locking portion installed on the first main body portion, and a second locking portion installed on the first main body portion or the second main body portion, the first locking portion is configured as: when loosening, the first main body portion and the mounting rod are movably connected, and when tightening, the first main body portion and the mounting rod are fixed; the second locking portion is configured as: when loosening, the second main body portion and the first main body portion are rotatably connected, and when tightening, the first main body portion and the second main body portion are fixed.

[0029] A method for using a donor perfusion device according to a second aspect of the present invention is applied to the donor perfusion device described in any one of the above embodiments, comprising the following steps:

[0030] Install consumables;

[0031] Turn on the control host switch and the program will self-check;

[0032] Filling the blood reservoir with priming liquid to switch the donor perfusion device to a self-circulation mode;

[0033] Blood is added to the blood reservoir to put the donor perfusion device into external circulation mode.

[0034] Additional aspects and advantages of the present invention will be given in part in the following description and in part will be obvious from the following description, or will be learned through practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] The present invention will be further described below with reference to the accompanying drawings and embodiments, wherein:

[0036] Figure 1 It is a schematic structural diagram of the donor perfusion device of the present invention;

[0037] Figure 2 It is a schematic diagram of the pipelines and circuits of the donor perfusion device of the present invention;

[0038] Figure 3 It is a schematic diagram of the consumables part of the donor perfusion device of the present invention;

[0039] Figure 4 It is a schematic structural diagram of a double pump head embodiment of the donor perfusion device of the present invention;

[0040] Figure 5 It is an exploded schematic diagram of the control host and the mounting platform of the present invention;

[0041] Figure 6 for Figure 5 A magnified schematic diagram of the middle A area;

[0042] Figure 7 A cross-sectional view of a control host and a mounting platform of the present invention;

[0043] Figure 8 for Figure 7 A magnified schematic diagram of the middle B area;

[0044] Fig. 9 Another cross-sectional view of the control host and the mounting platform of the present invention;

[0045] Fig.10 for Fig. 9 Enlarged schematic diagram of the middle C area;

[0046] Fig.11 It is a schematic diagram of the installation of the blood reservoir of the present invention;

[0047] Fig.12 It is a schematic structural diagram of the pipe clamp of the present invention.

[0048] Reference numerals:

[0049] Control host 100; Card slot 110;

[0050] Blood reservoir 200; input pipe 210; venous pressure sensor 211; liquid level sensor 220;

[0051] Processing assembly 300; oxygenator 310; air-oxygen mixer 311; air cylinder 312; oxygen cylinder 313; heater 320; heating water tank 321; filter 330; output pipe 331; arterial pressure sensor 332; circulation pipe 333;

[0052] Pump drive assembly 400; first pump body 410; second pump body 420; first pump head 430; flow sensor 440; second pump head 450; input three-way valve 460; output three-way valve 470;

[0053] Trolley 500; mounting platform 510; first housing 511; second housing 512; clamping member 513; first section 5131; second section 5132; limiting protrusion 5133; elastic member 514; adapter 515; first adapter section 5151; second adapter section 5152; button 516; mounting rod 520; mounting bracket 530; first main body 531; second main body 532; first locking portion 533; second locking portion 534;

[0054] Pipe clamp 600; fixed section 610; clamping protrusion 611; elastic section 620; abutting protrusion 630; DETAILED DESCRIPTION

[0055] Embodiments of the present invention are described in detail below, examples of which are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and cannot be understood as limiting the present invention.

[0056] In the description of the present invention, it should be understood that descriptions involving orientations, such as up, down, front, back, left, right, etc., and orientations or positional relationships indicated are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0057] In the description of the present invention, "several" means more than one, "many" means more than two, "greater than", "less than", "exceed", etc. are understood to exclude the number itself, and "above", "below", "within", etc. are understood to include the number itself. If there is a description of "first" or "second", it is only used for the purpose of distinguishing the technical features, and cannot be understood as indicating or implying the relative importance or implicitly indicating the number of the indicated technical features or implicitly indicating the order of the indicated technical features.

[0058] In the description of the present invention, unless otherwise clearly defined, terms such as setting, installing, connecting, etc. should be understood in a broad sense, and technicians in the relevant technical field can reasonably determine the specific meanings of the above terms in the present invention based on the specific content of the technical solution.

[0059] In the description of the present invention, the description with reference to the terms "one embodiment", "some embodiments", "illustrative embodiments", "examples", "specific examples", or "some examples" means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner.

[0060] Organ transplantation technology replaces organs that have lost their function due to disease or injury by transplanting healthy human organs into patients in need. From early kidney transplantation and liver transplantation to current lung transplantation and heart transplantation, the scope of organ transplantation has been continuously expanded and the technology has become increasingly mature.

[0061] In related technologies, organ transplantation often involves the ex vivo transport of organs, which requires the use of a donor perfusion device to simulate the environment of the organ in the human body, so as to maintain the activity of the organ. The donor perfusion device is often equipped with a blood pump to drive blood circulation. However, if the blood pump fails during the organ transport or transplantation process, it will seriously affect the activity of the organ and even cause organ death.

[0062] To solve the above problems, the present application proposes a donor perfusion device, which includes a control host 100, a blood reservoir 200, a processing component 300, a pump drive component 400, etc. Figures 1 to 3 The figure shows the overall schematic diagram of the operation of the donor perfusion device. Figure 2 As shown, the blood reservoir 200 is connected to an input pipe 210, and the input pipe 210 is used to communicate with the venous blood vessels of the donor (i.e., an isolated organ, not shown in the figure), so that venous blood can flow from the input pipe 210 to the blood reservoir 200, and the blood reservoir 200 is used to receive and store the blood input by the donor. The downstream of the blood reservoir 200 is connected to a pump drive component 400, and the downstream of the pump drive component 400 is connected to a processing component 300. It should be noted that the upstream and downstream referred to in this article are based on the flow direction of blood in the donor perfusion device. For example, the downstream of the blood reservoir 200 is connected to the pump drive component 400, which means that the blood first flows through the blood reservoir 200 and then flows to the pump drive component 400.

[0063] The pump drive assembly 400 is used to drive blood circulation and provide the donor with a blood pressure similar to that of the human body. The pump drive assembly 400 is connected to the blood reservoir 200 and the processing assembly 300 through pipelines to drive the blood to flow through the processing assembly 300 and then output to the donor.

[0064] The processing component 300 includes but is not limited to an oxygenator 310, a heater 320, a filter 330, etc., which are used to process the venous blood flowing out of the donor, thereby forming arterial blood with a higher oxygen content and a suitable temperature, and inputting it into the donor's arterial blood vessel through an output pipe 331 connected to the processing component 300, thereby completing the donor's blood circulation.

[0065] In such Figures 1 to 3 In the illustrated embodiment, the oxygenator 310 is connected to an air-oxygen mixer 311, and the air-oxygen mixer 311 is respectively connected to an air storage cylinder 312 and an oxygen storage cylinder 313. The gases in the air storage cylinder 312 and the oxygen storage cylinder 313 are mixed in a set ratio in the air-oxygen mixer 311 and then input into the oxygenator 310 to be mixed with the blood.

[0066] The heater 320 is connected to a heating water tank 321, which can provide warm water of suitable temperature for the heater 320, recover the cooling water in the heater 320, and heat the cooling water. The heater 320 heats the blood in the pipe passing through by the warm water provided by the heating water tank 321, and has good temperature stability.

[0067] The entire donor perfusion device is also provided with a plurality of sensors, and the control host 100 is communicatively connected with various sensors (such as the liquid level sensor 220 on the blood reservoir 200, the arterial pressure sensor 332 on the output pipe 331, etc.) and various components (such as the first pump body 410, the air-oxygen mixer 311, etc.), thereby realizing information collection and control of the entire donor perfusion device.

[0068] It should be noted that the pump drive assembly 400 of the present application includes two blood pumps, which are named as the first pump body 410 and the second pump body 420 for easy distinction. The first pump body 410 and the second pump body 420 are respectively connected to the control host 100 for communication, and the control host 100 can control the start and stop and the speed of the first pump body 410 and the second pump body 420. The pump drive assembly 400 has a first working condition and a second working condition. In the initial state, the pump drive assembly 400 is in the first working condition, the control host 100 controls the first pump body 410 to work, the second pump body 420 to stop working, and the blood is driven by the first pump body 410. When the first pump body 410 fails, the pump drive assembly 400 switches to the second working condition, at which time the control host 100 controls the second pump body 420 to work, the first pump body 410 stops working, and the blood is driven by the second pump body 420.

[0069] Based on the above, when the first pump body 410 of the donor perfusion device of the present application fails, the second pump body 420 can be started as a backup drive source, thereby continuing to drive the blood circulation to avoid prolonged ischemia of the donor. The donor perfusion device is more suitable for long-term organ transportation scenarios. The redundant design of the pump drive component 400 ensures the stable operation of the donor perfusion device in complex situations, thereby improving the reliability of the donor perfusion device.

[0070] It is understandable that the control host 100 can monitor the physiological parameters of the blood in the donor perfusion device or the working parameters of the blood pump, so as to promptly alarm when the first pump body 410 fails and switch the working condition of the pump drive assembly 400. In some embodiments, Figure 2 As shown, the donor perfusion device includes an output pipe 331, one end of the output pipe 331 is used to communicate with the processing component 300, and the other end is used to communicate with the donor. A sensor is provided on the output pipe 331, and the sensor is communicatively connected with the control host 100, so that the control host 100 can obtain the physiological parameters collected by the sensor. For example, the sensor can be a pressure sensor that can collect the pressure value of the blood in the output pipe 331, or the sensor can also be a flow rate sensor that can collect the flow rate of the blood in the output pipe 331.

[0071] The control host 100 obtains the physiological parameter values ​​collected by the sensor at set intervals, and can also obtain the physiological parameter values ​​collected by the sensor in real time, and compares the collected data with a preset setting range. If the value of the physiological parameter exceeds the set range, it is determined that the first pump body 410 is working abnormally. The control host 100 controls the second pump body 420 to work and the first pump body 410 to stop working, so that the pump drive component 400 switches from the first working condition to the second working condition.

[0072] Alternatively, in other embodiments, the control host 100 can also obtain the working parameters of the first pump body 410 at set time intervals or in real time, such as the voltage value, speed value and other working parameters of the first pump body 410, and compare the collected data with a preset setting range. If the working parameters are outside the set range, the control host 100 controls the pump drive component 400 to switch from the first working condition to the second working condition.

[0073] In some embodiments, after the control host 100 controls the pump drive assembly 400 to switch from the first operating condition to the second operating condition, the first pump body 410 needs to be repaired or replaced, and then the pump drive assembly 400 is switched from the second operating condition back to the first operating condition. In this embodiment, the second pump body 420 can use a lower-cost blood pump as a backup, and the second pump body 420 only serves as a temporary drive and does not undertake long-term driving tasks.

[0074] In other embodiments, after the control host 100 switches from the first working condition to the second working condition, the first pump body 410 is in a non-working state, and the staff can repair or replace the first pump body 410 to prevent the second pump body 420 from having an abnormality. After the control host 100 continues to drive blood with the second pump body 420, the control host 100 sets the current working condition to the first working condition, sets the second pump body 420 as the new first pump body 410, and sets the first pump body 410 as the new second pump body 420. In this way, both the first pump body 410 and the second pump body 420 can undertake long-term driving tasks, and there is no need to switch back to the original first pump body 410 for driving after the original first pump body 410 is repaired, which reduces the number of working condition switching and improves the stability of the entire donor perfusion device.

[0075] Based on the above, when the control host 100 detects an abnormality in the first pump body 410, it issues an alarm and controls the second pump body 420 to start working and the first pump body 410 to stop working. In some embodiments, after receiving the alarm message, the operator needs to cooperate with the control host 100 to complete the working state switching of the pump drive assembly 400. Specifically, Figure 1 As shown, the pump drive assembly 400 includes a first pump body 410, a second pump body 420 and a first pump head 430. The first pump head 430 can be detachably connected to the first pump body 410, or can be detachably connected to the second pump body 420. Both the first pump body 410 and the second pump body 420 can drive the first pump head 430 to operate. More specifically, the first pump head 430 contains an impeller (not shown in the figure). Both the first pump body 410 and the second pump body 420 adopt a magnetic drive structure. When the first pump head 430 is installed on the first pump body 410 or the second pump body 420, the first pump body 410 or the second pump body 420 can drive the impeller in the first pump head 430 to rotate, thereby promoting the accelerated flow of blood.

[0076] The first pump head 430 includes a liquid inlet and a liquid outlet. The liquid inlet is connected to the blood reservoir 200, and the liquid outlet is connected to the processing component 300. After the blood enters the first pump head 430 from the liquid inlet, it flows out from the liquid outlet through the impeller drive. It can be understood that according to the working condition of the pump drive component 400, the first pump head 430 is selectively connected to the first pump body 410 and the second pump body 420. That is, under the first working condition, the first pump head 430 is connected to the first pump body 410. When the control host 100 detects that the first pump body 410 fails and cannot complete the driving task as required, an alarm is issued to remind the operator, and the operator removes the first pump head 430 from the first pump body 410 and installs it on the second pump body 420. The control host 100 controls the second pump body 420 to work, thereby realizing the replacement of the driving source.

[0077] The implementation structure of this shared first pump body 410 is relatively simple. Blood flows along a fixed path of the blood reservoir 200, the first pump head 430, and the processing component 300 without changing the flow path, thereby reducing the connecting pipelines of the donor perfusion device, having low cost and simple operation.

[0078] Correspondingly, the present application also proposes another working mode switching mode, in which the donor perfusion device does not need to replace the pump head when the driving source is replaced. Figure 4 As shown, the pump drive assembly 400 includes two pump heads, which are named as the first pump head 430 and the second pump head 450 for easy distinction. The first pump head 430 is connected to the first pump body 410, and the first pump head 430 is respectively connected to the blood reservoir 200 and the processing assembly 300, and the second pump head 450 is connected to the second pump body 420, and the second pump head 450 is also respectively connected to the blood reservoir 200 and the processing assembly 300. That is, between the blood reservoir 200 and the processing component 300, there are two parallel pipelines flowing through the first pump head 430 and the second pump head 450 respectively. Under the first working condition, the blood reservoir 200, the first pump head 430 and the processing component 300 form a passage through which blood can circulate, and the blood reservoir 200, the second pump head 450 and the processing component 300 are closed and blood cannot circulate. Under the second working condition, the blood reservoir 200, the second pump head 450 and the processing component 300 form a passage through which blood can circulate, and the blood reservoir 200, the first pump head 430 and the processing component 300 are closed and blood cannot circulate.

[0079] One of the two parallel pipelines is opened and the other is closed. The closing method can be manual, for example, the operator uses a pipeline clamp to lock the inlet pipe of the first pump head 430 or the outlet pipe of the first pump head 430 after receiving the warning information from the control host 100. Alternatively, the closing method can also be automatic, for example, Figure 4 As shown, the pump drive assembly 400 further includes two electric three-way valves, which are respectively set as an input three-way valve 460 and an output three-way valve 470 for easy distinction. The three ports of the input three-way valve 460 are respectively connected to the blood reservoir 200, the input port of the first pump head 430, and the input port of the second pump head 450. The three ports of the output three-way valve 470 are respectively connected to the processing assembly 300, the output port of the first pump head 430, and the output port of the second pump head 450.

[0080] The input three-way valve 460 and the output three-way valve 470 are respectively connected to the control host 100 for communication, and are switched on and off under the control of the control host 100. In the first working condition, the input three-way valve 460 connects the blood reservoir 200 with the input port of the first pump head 430, and is closed with the input port of the second pump head 450, and the output three-way valve 470 connects the output port of the first pump head 430 with the processing assembly 300, and the output port of the second pump head 450 is closed to prevent blood reflux. Thus, in the first working condition, blood can pass through the blood reservoir 200, the input port of the first pump head 430, the output port of the first pump head 430, and the processing assembly 300 in sequence. Similarly, under the second working condition, the input three-way valve 460 connects the blood reservoir 200 with the input port of the second pump head 450, and the output three-way valve 470 connects the output port of the second pump head 450 with the processing component 300, so that blood can pass through the blood reservoir 200, the input port of the second pump head 450, the output port of the second pump head 450 and the processing component 300 in sequence.

[0081] It is understandable that by providing the above-mentioned input three-way valve 460 and output three-way valve 470, it is possible to realize automatic switching of the two parallel pipelines, so that when the first pump body 410 fails, the blood can be automatically directed to the pipeline connected to the second pump body 420, achieving efficient and automatic switching, greatly shortening the replacement time of the driving source, and reducing the adverse effects of replacing the driving source on the donor. In addition, if the first pump head 430 is blocked or otherwise fails, the structure in this embodiment can also realize the replacement of the driving source, thereby avoiding the impact on the donor.

[0082] It should be noted that in the present application, the blood reservoir 200, the connecting pipeline for blood circulation, etc. are all disposable consumables. Therefore, after each replacement of the consumables and before connecting to the donor, the air in the pipeline must be discharged to prevent the air in the pipeline from being filled into the donor to produce air embolism and damage the isolated organ. Therefore, the donor perfusion device of the present application includes a self-circulation mode and an external circulation mode. The self-circulation mode is used to discharge the air in the pipeline, and the external circulation mode is used to connect the donor for blood supply. In the self-circulation mode, the blood reservoir 200 is filled with a pre-filled liquid, and the gas in the pipeline is discharged by circulating the pre-filled liquid. The input pipeline 210 is connected to the output pipeline 331, so that the pre-filled liquid can circulate in the donor perfusion device, and flows back to the blood reservoir 200 through the blood reservoir 200, the pump drive assembly 400, the processing assembly 300, the output pipeline 331, and the input pipeline 210, and the air is released in the blood reservoir 200. It should be explained that the input pipeline 210 and the output pipeline 331 can be an integrally formed pipeline, which is connected in the self-circulation mode. When it is necessary to connect with the donor, it is cut into an independent input pipeline 210 and an output pipeline 331.

[0083] It is understandable that, since two parallel pipelines are provided from the blood reservoir 200 to the processing component 300 in the embodiment of the present application, and two sets of driving sources are provided, for this reason, in the early self-circulation mode, the two parallel pipelines and driving sources need to be respectively exhausted, that is, in the self-circulation mode, the control host 100 controls the pump drive component 400 to switch the working state at least once. It should be explained that in this working state switching, it is actively triggered by the program definition, and there is no need for the control host 100 to be passively triggered after detecting an abnormal situation. For example, after the pump drive component 400 is pre-filled with liquid for a period of time with the first pump body 410 and the first pump head 430, the control host 100 actively controls the pump drive component 400 to switch to the second working state, and the second pump body 420 and the second pump head 450 are pre-filled with liquid to drive, thereby exhausting the air in the pipeline where the second pump head 450 is located.

[0084] In some embodiments, Figure 2 As shown, the donor perfusion device also includes a circulation pipeline 333, one end of which is connected to the blood reservoir 200, and the other end is connected to the processing component 300. When the output pipeline 331 and the input pipeline 210 are ready to be connected to the donor, the output pipeline 331 and the input pipeline 210 need to be separated, and the input pipeline 210 is inserted into the donor's venous blood vessel, and the output pipeline 331 is inserted into the donor's arterial blood vessel. During the insertion process, in order to ensure the docking of the output pipeline 331 and the arterial blood vessel, the blood outflow in the output pipeline 331 needs to be temporarily stopped. At this time, the output pipeline 331 is closed by the pipeline clamp 600, and the circulation pipeline 333 is opened, so that the blood can flow back from the circulation pipeline 333 to the blood reservoir 200, and will not flow out through the output pipeline 331. After the output pipeline 331 is connected to the donor, the circulation pipeline 333 is closed by the pipeline clamp 600, so that the blood no longer flows back through the circulation pipeline 333, but is directly output to the donor blood vessel.

[0085] In such Figure 2 In the illustrated embodiment, the liquid outlet pipe of the filter 330 is connected to a three-way joint, one port of the three-way joint is connected to the output pipe 331 , and the other port of the three-way joint is connected to the circulation pipe 333 .

[0086] More detailed, such as Figure 3 and Fig.12In the embodiment shown, the pipe clamp 600 is formed by integral injection molding of plastic material, and includes a fixed section 610 and an elastic section 620 connected to the fixed section 610. The fixed section 610 is provided with a through hole for the pipe to pass through. The pipe is arranged in the fixed section 610 and is partially located between the fixed section 610 and the elastic section 620. The fixed section 610 and the elastic section 620 are respectively provided with abutment protrusions 630 arranged opposite to each other. One end of the elastic section 620 is integrally connected to the fixed section 610, and the other end can be engaged with the fixed section 610, so that the abutment protrusions 630 on the fixed section 610 and the elastic section 620 are respectively pressed against the two sides of the pipe to reduce the cross-sectional area of ​​the pipe. In addition, the fixed section 610 is provided with a plurality of engaging protrusions 611 for engaging with the elastic section 620. When the elastic section 620 is engaged with different engaging protrusions 611, the degree of abutment of the pipe by the abutment protrusions 630 on the elastic section 620 and the fixed section 610 changes accordingly. When at least one of the clamping protrusions 611 abuts against the elastic section 620 , the abutting protrusions 630 on both sides press the pipe walls on both sides of the pipe together, thereby completely closing the pipe.

[0087] In some embodiments, Figure 1 , Figures 5 to 11 As shown, the donor perfusion device also includes a trolley 500, which is provided with rollers and can be easily moved. The trolley 500 is provided with a mounting platform 510, and the mounting platform 510 is provided with a clamping assembly. The opposite side walls of the control host 100 are respectively provided with clamping grooves 110. When the control host 100 is placed on the mounting platform 510, the clamping assembly is used to clamp the clamping grooves 110. When the control host 100 is installed on the mounting platform 510 of the trolley 500, its displacement is limited by the clamping assembly, thereby reducing the risk of the control host 100 falling and being damaged during transportation. In addition, the control host 100 is arranged on the trolley 500, which is conducive to the operator moving the control host 100, greatly improving the convenience of transporting the donor perfusion device.

[0088] Specifically, Figure 5 and Figure 6 As shown, the mounting platform 510 includes a first shell 511 and a second shell 512. Figure 5 As shown, the first shell 511 is a shell structure, and an opening is provided at its lower end. The second shell 512 can be detachably connected to the first shell 511, and covers and closes the lower end opening of the first shell 511, so that the first shell 511 and the second shell 512 jointly define a transmission cavity. The mounting platform 510 also includes a clamping member 513, an elastic member 514, and a transfer member 515 disposed in the transmission cavity, and the mounting platform 510 also includes a button 516, which is movably connected to the first shell 511.

[0089] The card connector 513 is as follows Figure 7 and Figure 8The shape shown in the figure includes a first section 5131 and a second section 5132 which are integrally formed and intersected with each other. The first section 5131 is used to abut against the adapter 515. The end of the second section 5132 includes a protruding limit protrusion 5133. An opening is provided on the first shell 511. The clamping member 513 is rotatably connected to the second shell 512. The elastic member 514 is connected to the clamping member 513. The elastic member 514 can be a torsion spring. The elastic member 514 is used to maintain the clamping member 513 in a state where the limit protrusion 5133 extends out of the opening. Fig. 9 and Fig.10 As shown, one end of the adapter 515 can abut against the first section 5131 of the clamping member 513, thereby driving the clamping member 513 to rotate and compress the elastic member 514, and the other end of the adapter 515 can abut against the button 516. The middle part of the adapter 515 is rotatably connected to the second shell 512, and can rotate with the middle part of the adapter 515 as a rotation fulcrum, so that the downward pressure of the button 516 can drive the adapter 515 to rotate and drive the first section 5131 of the clamping member 513 at the other end to rotate upward, so that the limiting protrusion 5133 of the second section 5132 is retracted into the first shell 511.

[0090] It is understandable that the number of the clamping member 513 and the elastic member 514 can be two, and the adapter 515 and the button 516 can be one. Figure 6 As shown, the adapter 515 includes a first adapter section 5151 for abutting against the button 516 and a second adapter section 5152 for abutting against the snap-in member 513. The first adapter section 5151 and the second adapter section 5152 are fixedly connected, and the first adapter section 5151 is connected to the middle of the second adapter section 5152, so that the two ends of the second adapter section 5152 can respectively abut against a snap-in member 513 to cooperate with the snap-in grooves 110 on both sides of the control host 100 to limit the control host 100.

[0091] For the convenience of description, the two states of the clamping member 513 are named as the first state and the second state respectively. The first state is a long-term state that the clamping member 513 can maintain when there is no force applied by the operator to press the button 516. In this state, the clamping member 513 is driven by the elastic member 514 to maintain a position partially protruding from the first shell 511, and the portion of the clamping member 513 protruding from the first shell 511 (that is, the aforementioned limiting protrusion 5133) can be embedded in the clamping groove 110 on the side of the control host 100 to limit the movement of the control host 100. In the second state, as shown in FIG. Figure 8Taking the embodiment shown as an example, the second adapter section 5152 of the adapter 515 moves upward to make the clamping member 513 rotate clockwise, so that the limiting protrusion 5133 is retracted into the first shell 511. At this time, the clamping member 513 is withdrawn from the clamping groove 110, so that the control host 100 can be separated from the mounting platform 510. It should be noted that the button 516 is driven by the elastic member 514 and the abutment of the adapter 515 when it is not pressed by the operator, and protrudes from the surface of the first shell 511. The operator can press the button 516 to make the end of the adapter 515 abutting against the button 516 move downward and the other end lift, thereby driving the clamping member 513 to switch from the first state to the second state.

[0092] In addition, the trolley 500 is also provided with a mounting rod 520 and a mounting bracket 530 disposed on the mounting rod 520 for mounting the pump drive assembly 400 and the blood reservoir 200, etc. Thus, the trolley 500 can realize the integrated installation of various machines in the donor perfusion device, which is conducive to unified transportation during the transportation process.

[0093] Specifically, Figure 1 and Fig.11 As shown, the mounting rod 520 is arranged in the vertical direction, and the mounting bracket 530 includes a first main body 531, a second main body 532, a first locking part 533 and a second locking part 534. The first main body 531 is sleeved on the mounting rod 520, the second main body 532 is rotatably connected to the first main body 531, and the first locking part 533 is threadedly connected to the first main body 531. When the first locking part 533 is gradually tightened, the first locking part 533 can pass through the first main body 531 and abut against the mounting rod 520, so that the first main body 531 and the mounting rod 520 are fixedly connected, thereby limiting the position of the first main body 531 on the mounting rod 520. When the first locking part 533 is loosened, the first locking part 533 is separated from the mounting rod 520, so that the first main body 531 can rotate or move up and down compared with the mounting rod 520. The second locking portion 534 can be threadedly connected to any one of the first body portion 531 and the second body portion 532 so as to Fig.11 Taking the example of the second locking portion 534 being threadedly connected to the first main body portion 531, when the second locking portion 534 is tightened, the second locking portion 534 passes through the first main body portion 531 and abuts against the second main body portion 532, so that the first main body portion 531 and the second main body portion 532 are fixedly connected, thereby limiting the rotational freedom of the second main body portion 532 compared to the first main body portion 531. When the second locking portion 534 is loosened, the second main body portion 532 can rotate compared to the first main body portion 531.

[0094] It can be understood that, by setting the first locking portion 533 and the second locking portion 534, the installation of the blood reservoir 200, the pump drive assembly 400 and other devices has a large free adjustable space, which can meet the use requirements of operators in different scenarios. In addition, the second main body 532 can adopt different structures to adapt to the connection with different devices, for example, Figure 1 In the embodiment shown, the second main body 532 connected to the pump drive assembly 400 is a straight plate structure, attached to the lower wall of the pump body and fixed to the pump body by screws. Fig.11 As shown, the second main body 532 connected to the blood reservoir 200 is an annular structure. During installation, the blood reservoir 200 can be inserted into the second main body 532 and abut against the second main body 532, thereby fixing the blood reservoir 200.

[0095] In some embodiments, an arterial pressure sensor 332 is provided on the output pipeline 331, a venous pressure sensor 211 is provided on the input pipeline 210, a flow sensor 440 is provided on the pipeline downstream of the pump drive assembly 400, a temperature sensor is provided on the heater 320 or on the pipeline downstream of the heater 320, and the blood reservoir 200 is provided with a liquid level sensor 220, etc. The above sensors are all communicated with the control host 100, so that the control host 100 can develop an intelligent control algorithm based on the physiological parameters and perfusion parameters collected by the sensors in real time, apply filtering and anti-shake algorithms, and combine clinical data to evaluate the organ perfusion status in real time and calculate the optimal intervention measures, control the pump speed to achieve automatic adjustment of flow and pressure, and ensure that the blood level in the blood reservoir 200 is always in a safe position to avoid safety accidents caused by blood extraction.

[0096] In summary, the present application proposes a combined donor perfusion device, which assembles various components on a trolley 500, is easy to use, flexible to operate, and can monitor the perfusion status in real time and make intelligent adjustments. The physiological parameters of blood and the working parameters of perfusion are collected in real time through various sensors such as temperature sensors, flow rate sensors, and pressure sensors, so as to evaluate the perfusion status of the donor and calculate the optimal intervention measures, control the pump speed to achieve automatic adjustment of flow and pressure, or trigger an alarm to remind the operator to intervene manually, thereby realizing the human-computer interaction function.

[0097] The second aspect of the present application also provides a method for using a donor perfusion device, which can be applied to the donor perfusion device mentioned in any of the above embodiments. The method includes the following steps:

[0098] S100, installation of consumables;

[0099] Based on the foregoing, in the present application, the blood reservoir 200, the pipelines used for circulating blood, etc. are all disposable consumables and need to be replaced after one use to prevent cross infection.

[0100] S200, turn on the control host 100, and the program self-checks;

[0101] In this step, the control host 100 supplies power to each sensor and detects whether each sensor can operate normally.

[0102] S300, adding priming liquid into the blood reservoir 200, so that the donor perfusion device switches to the self-circulation mode;

[0103] In this step, the pre-filled liquid needs to be self-circulated to discharge the air in each pipe. It should be noted that in the self-circulation mode, the output pipe 331 and the input pipe 210 are in a connected relationship. For example, the output pipe 331 and the input pipe 210 are integrally formed pipes, and the integrated through structure is maintained in the self-circulation mode, so that the pre-filled liquid can flow from the output pipe 331 through the input pipe 210 and then flow back to the blood reservoir 200. Alternatively, the output pipe 331 and the input pipe 210 are independent pipes, which are connected to form a through structure in the self-circulation mode.

[0104] S400, replenishing blood into the blood reservoir 200, so that the donor perfusion device enters the external circulation mode;

[0105] This step also includes the following steps: first, if the output pipe 331 and the input pipe 210 are integrally formed pipes, they need to be cut in this step to form the output pipe 331 and the input pipe 210 respectively, and the input pipe 210 can be connected to the donor's venous blood vessel so that the blood flowing out of the donor can be collected by the blood reservoir 200. The donor perfusion device uses blood for circulation and gradually discharges the pre-filled liquid through the output pipe 331. After the blood is discharged from the output pipe 331, the output pipe 331 is closed by a pipe clamp, and the circulation pipe 333 is opened to stop the blood from flowing out of the output pipe 331, and then the output pipe 331 and the donor artery are connected. After the connection is completed, the output pipe 331 is opened and the circulation pipe 333 is closed to put the donor perfusion device into the external circulation mode, and the donor's blood can be oxygenated, heated, filtered and circulated through the donor perfusion device to maintain the activity of the donor.

[0106] The embodiments of the present invention are described in detail above in conjunction with the accompanying drawings, but the present invention is not limited to the above embodiments. Various changes can be made within the knowledge of ordinary technicians in the relevant technical field without departing from the purpose of the present invention. In addition, the embodiments of the present invention and the features in the embodiments can be combined with each other without conflict.

Claims

1. A donor perfusion device, characterized in that: include: Control host; A blood reservoir, the blood reservoir is used to receive blood transfused from a donor; A processing component, through which the blood is output to the donor; A pump drive assembly, the pump drive assembly is respectively connected to the blood reservoir and the processing assembly to drive the blood to flow through the processing assembly and then output, the pump drive assembly includes a first pump body and a second pump body, the first pump body and the second pump body are respectively connected to the control host for communication; Wherein, the pump drive assembly has a first working condition and a second working condition. In the first working condition, the control host controls the first pump body to work, and in the second working condition, the control host controls the second pump body to work.

2. The donor perfusion device according to claim 1, characterized in that: The donor perfusion device comprises an output pipeline, one end of which is connected to the processing component, and the other end is used to communicate with the donor, the output pipeline is provided with a sensor connected to the control host, the control host obtains the physiological parameters collected by the sensor, and if the physiological parameters are out of the set range, the control host controls the pump drive component to switch from the first working condition to the second working condition; Alternatively, the control host obtains the working parameters of the first pump body, and if the working parameters are outside a set range, the control host controls the pump drive component to switch from the first working condition to the second working condition.

3. The donor perfusion device according to claim 1, characterized in that: After the control host switches from the first working condition to the second working condition, the current working condition is set as the first working condition, the second pump body is set as the new first pump body, and the first pump body is set as the new second pump body.

4. The donor perfusion device according to claim 1, characterized in that: The pump drive assembly includes a first pump head that can be detachably connected to either the first pump body or the second pump body. Both the first pump body and the second pump body can drive the first pump head to operate. The first pump head is respectively connected to the blood reservoir and the processing assembly. Under the first operating condition, the first pump head is connected to the first pump body, and under the second operating condition, the first pump head is connected to the second pump body.

5. The donor perfusion device according to claim 1, characterized in that: The pump drive assembly includes a first pump head connected to the first pump body, and the first pump head is communicated with the blood reservoir and the processing assembly respectively. The pump drive assembly also includes a second pump head connected to the second pump body, and the second pump head is communicated with the blood reservoir and the processing assembly respectively. Under the first operating condition, the blood reservoir, the first pump head and the processing assembly form a passage. Under the second operating condition, the blood reservoir, the second pump head and the processing assembly form a passage.

6. The donor perfusion device according to claim 5, characterized in that: The pump drive assembly further includes an input three-way valve and an output three-way valve, each port of the input three-way valve is respectively connected to the blood reservoir, the input port of the first pump head and the input port of the second pump head, and each port of the output three-way valve is respectively connected to the processing assembly, the output port of the first pump head and the output port of the second pump head; Among them, the input three-way valve and the output three-way valve are respectively connected to the control host for communication, and are switched on and off under the control of the control host. Under the first working condition, the blood reservoir, the input port of the first pump head, the output port of the first pump head and the processing component are connected in sequence; under the second working condition, the blood reservoir, the input port of the second pump head, the output port of the second pump head and the processing component are connected in sequence.

7. The donor perfusion device according to claim 5, characterized in that: The donor perfusion device comprises an input pipe connected to the blood reservoir and an output pipe connected to the processing assembly, and the donor perfusion device comprises a self-circulation mode and an external circulation mode. In the self-circulation mode, the input pipe is connected to the output pipe, and in the external circulation mode, the input pipe is used to communicate with the donor, and the output pipe is used to communicate with the donor; The donor perfusion device switches to the external circulation mode after executing the self-circulation mode for a set time, wherein in the self-circulation mode, the control host controls the pump drive component to switch the working condition at least once.

8. The donor perfusion device according to claim 1, characterized in that: The donor perfusion device comprises an input conduit in communication with the blood reservoir and an output conduit in communication with the processing assembly, wherein the output conduit is used to communicate with the donor; Wherein, the donor perfusion device also includes a circulation pipeline, one end of which is connected to the blood reservoir, and the other end is connected to the processing component. When the output pipeline and the input pipeline are ready to be connected to the donor, at least the output pipeline is closed and the circulation pipeline is opened. After the output pipeline is connected to the donor, the circulation pipeline is closed.

9. The donor perfusion device according to claim 1, characterized in that: The donor perfusion device also includes a trolley, which is provided with a mounting platform, and the mounting platform is provided with a clamping assembly. The opposite side walls of the control host are respectively provided with clamping grooves. When the control host is placed on the mounting platform, the clamping assembly is clamped with the clamping groove.

10. The donor perfusion device according to claim 9, characterized in that: The mounting platform includes a first shell and a second shell, wherein the first shell and the second shell define a transmission cavity, and the mounting platform further includes a clamping member, an elastic member, a conversion member, and a key movably connected to the first shell and arranged in the transmission cavity, wherein the elastic member is connected to the clamping member, and the clamping member and the conversion member are rotatably connected to the second shell respectively; In which, the clamping member has a first state in which it is driven by the elastic member and partially protrudes from the first shell. In the first state, the protruding part of the clamping member can be embedded in the clamping groove to limit the movement of the control host; and the clamping member also has a second state in which it is driven by the adapter and retracted to the first shell. In the second state, the clamping member is located outside the clamping groove, and the control host can be separated from the mounting platform; the button is configured to: drive the adapter to rotate when pressed, so as to drive the clamping member to switch from the first state to the second state.

11. The donor perfusion device according to claim 9, characterized in that: The trolley is also provided with a mounting rod and a mounting bracket arranged on the mounting rod, the mounting bracket includes a first main body portion sleeved on the mounting rod, a second main body portion rotatably connected to the first main body portion, a first locking portion installed on the first main body portion, and a second locking portion installed on the first main body portion or the second main body portion, the first locking portion is configured as follows: when loosening, the first main body portion and the mounting rod are movably connected, and when tightening, the first main body portion and the mounting rod are fixed; the second locking portion is configured as follows: when loosening, the second main body portion and the first main body portion are rotatably connected, and when tightening, the first main body portion and the second main body portion are fixed.

12. A method for using a donor perfusion device, applied to the donor perfusion device according to any one of claims 1 to 11, characterized in that: The following steps are involved: Install consumables; Turn on the control host switch and the program will self-check; Filling the blood reservoir with priming liquid to switch the donor perfusion device to a self-circulation mode; Blood is added to the blood reservoir to put the donor perfusion device into external circulation mode.

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