Forsythia suspense processing technology and processed forsythia suspense

Abstract

The invention relates to the technical field of traditional Chinese medicine processing, and particularly discloses a fructus forsythiae processing technology and processed fructus forsythiae. The fructus forsythiae processing technology comprises the following steps: putting a crude fructus forsythiae product in steam generated after boiling of heated ultrapure water in a pressurized environment, controlling the steam temperature to be 120-150 DEG C, performing steam fixation for 8-12 minutes, and drying the fructus forsythiae subjected to steam fixation to obtain processed fructus forsythiae. According to the processed fructus forsythiae obtained through the processing technology, the content of forsythin in the processed fructus forsythiae reaches 0.78% or above, the content of forsythiaside A reaches 2.65% or above, and the overall quality and the medicine effect of the fructus forsythiae are remarkably improved.

Description

Technical Field

[0001] The present application relates to the technical field of Chinese medicine processing, and in particular to a processing technology for Forsythia suspensa and processed Forsythia suspensa. Background Art

[0002] Forsythia suspensa has the effects of clearing away heat and detoxifying, reducing swelling and dispersing nodules. It is one of the traditional Chinese medicines commonly used in clinical practice in China. It is often used to treat acute wind-heat colds, lymph node tuberculosis and other diseases. Its main chemical components include lignans, flavonoids, volatile oils and phenylethanol glycosides. Modern pharmacological studies have shown that bioactive substances represented by forsythia glycosides have obvious therapeutic effects on cognitive impairment. At the same time, they also have broad application prospects in antibacterial and anti-inflammatory, antipyretic, lipid-lowering and liver-protecting, anti-oxidation and anti-ototoxicity.

[0003] The quality of Forsythia suspensa is closely related to the processing method. However, due to limited conditions, Forsythia suspensa is currently processed by farmers based on experience. Most of them are processed by sun drying or kang baking, or by boiling in water before sun drying. The sun drying or kang baking method will cause a large loss of active ingredients such as forsythia glycoside and forsythia glycoside A in Forsythia suspensa. The method of boiling in water before sun drying will also cause the active ingredients such as forsythia glycoside and forsythia glycoside A in Forsythia suspensa to be lost with water, resulting in a decline in the quality of Forsythia suspensa, directly affecting the efficacy of Forsythia suspensa, and even bringing risks to the production of Chinese patent medicines. Summary of the invention

[0004] In order to solve the above technical problems, the present application provides a Forsythia suspensa processing technology and Forsythia suspensa after processing.

[0005] In a first aspect, the present application provides a processing process for Forsythia suspensa, comprising the following steps: placing a crude Forsythia suspensa product in steam generated by boiling ultrapure water heated in a pressurized environment, controlling the steam temperature to 120-150°C, steam sterilizing for 8-12 minutes, and drying the steam sterilized Forsythia suspensa to obtain processed Forsythia suspensa.

[0006] By adopting the above technical solution, the retention rate of effective ingredients in Forsythia suspensa, such as forsythin and forsythiaside A, can be significantly improved. Specifically, the use of high-temperature steam to kill the green can quickly reduce the enzyme activity in the cells in a short period of time, prevent the effective ingredients from decomposing due to oxidation, and avoid the problem of water taking away the effective ingredients during the traditional boiling process. In addition, the subsequent drying process further ensures the stability and safety of the medicinal materials, and ultimately the forsythin content in the processed Forsythia suspensa reaches more than 0.78%, and the forsythiaside A content reaches more than 2.65%, thereby improving the overall quality and efficacy of Forsythia suspensa.

[0007] Preferably, the steam temperature is controlled at 130-140° C., and the steam sterilization is performed for 10 minutes.

[0008] By adopting the above technical solution, the present application accurately controls the steam temperature at 130-140°C and maintains the steam killing time for 10 minutes, which can more effectively destroy the enzyme activity in Forsythia suspensa and reduce the decomposition of active ingredients such as forsythiaside and forsythiaside A, thereby significantly increasing the content of active ingredients in Forsythia suspensa after processing. This not only improves the efficacy of Forsythia suspensa, but also ensures the consistency and stability of its quality.

[0009] Preferably, the steam temperature is controlled to be 135°C.

[0010] By adopting the above technical solution, the steam temperature is precisely controlled at 135℃ and the steam killing is continued for 10 minutes, which can further increase the content of forsythiaside and forsythiaside A in Forsythia suspensa, thereby improving the quality and efficacy of Forsythia suspensa after processing. This optimization measure can ensure that the active ingredients in Forsythia suspensa are retained to the maximum extent, reduce the loss of active ingredients caused by too high or too low temperature, and make the final product more stable and reliable.

[0011] Preferably, the drying is reduced-pressure drying, and the pressure during drying is controlled at 0.05-0.1 MPa, the drying temperature is controlled at 60-90° C., and the drying time is 12-15 min.

[0012] By adopting the above technical scheme, the processing process of the present application can significantly improve the retention rate of the effective ingredients in Forsythia suspensa. Specifically, the reduced-pressure drying method can reduce the impact of the external environment on the evaporation of water inside Forsythia suspensa, thereby avoiding the destruction of effective ingredients caused by high temperature in the traditional drying process. In addition, the temperature- and pressure-controlled drying process can maximize the stability and content of key bioactive substances such as forsythiaside and forsythiaside A while ensuring the drying of Forsythia suspensa, so that forsythiaside reaches more than 0.78% and forsythiaside A reaches more than 2.65%, ensuring the quality and efficacy of Forsythia suspensa medicinal materials.

[0013] Preferably, the pressure reduction drying is carried out in three steps, specifically: first, the pressure is controlled at 0.05 MPa, the drying temperature is controlled at 90°C, and drying is performed for 4-5 minutes; then the pressure is increased by 0.02-0.03 MPa, the temperature is reduced by 10-20°C, and drying is performed for 4-5 minutes; finally, the pressure is increased to 0.1 MPa, the temperature is reduced to 60°C, and drying is performed for another 4-5 minutes to end drying.

[0014] By adopting the above technical scheme, the pressure is first controlled at 0.05MPa, the drying temperature is controlled at 90℃, and the drying is performed for 4-5min, so that the moisture on the surface of Forsythia suspensa evaporates quickly and the loss of effective ingredients is reduced; then the pressure is increased by 0.02-0.03MPa, the temperature is reduced by 10-20℃, and the drying is performed for 4-5min, so as to further reduce the moisture content inside Forsythia suspensa and avoid the damage of effective ingredients to high temperature; finally, the pressure is increased to 0.1MPa, the temperature is reduced to 60℃, and the drying is performed for another 4-5min to ensure that Forsythia suspensa is completely dried and the stability and preservation of the final product are improved. The whole process not only reduces the loss of effective ingredients in Forsythia suspensa, but also improves the quality and efficacy of Forsythia suspensa after processing.

[0015] Preferably, the reduced pressure drying is specifically as follows: first, the pressure is controlled at 0.05 MPa, the drying temperature is controlled at 90°C, and drying is performed for 4-5 minutes; then, the pressure is increased by 0.025 MPa, the temperature is decreased by 15°C, and drying is performed for 4-5 minutes; finally, the pressure is increased to 0.1 MPa, the temperature is decreased to 60°C, and drying is performed for another 4-5 minutes to terminate drying.

[0016] By adopting the above technical solution, the specific steps of the reduced pressure drying can more accurately control the evaporation rate and direction of the internal water of Forsythia suspensa, avoiding the loss of effective ingredients caused by high temperature and high pressure. First, drying at 0.05MPa and 90℃ for 4-5 minutes can quickly remove surface moisture and reduce thermal damage to effective ingredients; then increase the pressure by 0.025MPa, reduce the temperature by 15℃, and dry again for 4-5 minutes, which helps to further remove deep moisture and prevent the structural damage of Forsythia suspensa caused by too fast temperature increase; finally, increase the pressure to 0.1MPa, reduce the temperature to 60℃, and dry for another 4-5 minutes to ensure that the moisture content of the final product meets the standard, while retaining key active ingredients such as forsythiaside and forsythiaside A to the maximum extent. This series of delicate operations significantly improves the quality and stability of Forsythia suspensa after processing.

[0017] Preferably, the crude Forsythia suspensa product is also subjected to refrigeration treatment before steam sterilization, specifically: the crude Forsythia suspensa product is refrigerated for 5-6 hours under normal pressure environment, and the refrigeration temperature is 0-10°C.

[0018] By adopting the above technical scheme, the crude Forsythia suspensa of the present application is also refrigerated before steam killing, which can effectively reduce the loss of effective ingredients such as forsythiaside and forsythiaside A in Forsythia suspensa. Specifically, the crude Forsythia suspensa is refrigerated for 5-6 hours under normal pressure, and the refrigeration temperature is controlled within the range of 0-10°C, which can significantly inhibit the enzymatic hydrolysis reaction of the effective ingredients in Forsythia suspensa, maintain its original biological activity, thereby improving the retention rate of these effective ingredients in the subsequent processing process, and finally making the forsythiaside content in the processed Forsythia suspensa reach more than 0.78%, and the forsythiaside A content reach more than 2.65%.

[0019] Preferably, the crude Forsythia suspensa product is further cleaned and washed before refrigeration.

[0020] By adopting the above technical scheme, the crude Forsythia suspensa of the present application is also cleaned and washed before refrigeration. This step of treatment can remove impurities and dirt, improve the purity of the raw materials, thereby reducing the impact of impurities on the extraction of effective ingredients during the subsequent processing, and ensuring the quality and efficacy of the Forsythia suspensa after final processing.

[0021] In a second aspect, the present application provides processed Fructus Forsythiae obtained by the above-mentioned Fructus Forsythiae processing process, wherein the content of forsythiaside in the processed Fructus Forsythiae is ≥0.78%, and the content of forsythiaside A is ≥2.65%.

[0022] By adopting the above technical scheme, the processed Forsythia suspensa obtained by the processing process of Forsythia suspensa of the present application effectively retains the main biologically active ingredients in Forsythia suspensa, such as forsythin and forsythiaside A, during the process of refrigeration treatment, steam sterilization and multiple pressure reduction drying. Specifically, the refrigeration treatment freezes the water in the crude Forsythia suspensa, reduces the reproduction of microorganisms, and thus keeps the effective ingredients of Forsythia suspensa undamaged. The steam sterilization quickly kills the enzyme activity through high-temperature steam, prevents the oxidative decomposition of the effective ingredients in Forsythia suspensa, and ensures the quality stability and uniformity of Forsythia suspensa. The multiple pressure reduction drying avoids the problem of loss of effective ingredients due to excessive temperature in the traditional drying method by gradually adjusting the pressure and temperature, and further increases the content of forsythin and forsythiaside A in Forsythia suspensa. Finally, this processing process can significantly increase the content of forsythin in the processed Forsythia suspensa to more than 0.78%, and the content of forsythiaside A to more than 2.65%, thereby ensuring the efficacy of Forsythia suspensa and improving its reliability and effectiveness in medical applications.

[0023] In summary, this application has the following beneficial technical effects: 1. The forsythia processing process of the present application effectively prevents the loss of effective ingredients such as forsythiaside and forsythiaside A in forsythia by controlling the steam temperature and time for steam killing, and improves the content of effective ingredients in forsythia after processing, especially forsythiaside can reach more than 0.78%, forsythiaside A can reach more than 2.65%; 2. The Forsythia suspensa processing process of the present application avoids the decomposition of the active ingredients caused by high temperature and long-term drying through multiple pressure reduction drying processes, thereby ensuring the efficacy stability and safety of Forsythia suspensa; 3. The Forsythia suspensa processing process of the present application reduces the oxidation reaction of Forsythia suspensa before processing through refrigeration treatment, further protects the effective ingredients, and improves the overall quality of Forsythia suspensa after processing. DETAILED DESCRIPTION

[0024] The present application is further described in detail below in conjunction with embodiments and comparative examples.

[0025] Example 1.1 A processing technology for Fructus Forsythiae comprises the following steps: The crude Forsythia suspensa was placed in the steam generated by boiling ultrapure water heated in a pressurized environment, the steam temperature was controlled to 150°C, and the steam was sterilized for 8 minutes. The Forsythia suspensa after steam sterilization was dried, and the normal pressure environment was maintained. The drying temperature was maintained at 60°C and the drying time was 20 minutes. After the drying was completed, the processed Forsythia suspensa was obtained.

[0026] Example 1.2 A processing technology for Fructus Forsythiae comprises the following steps: The crude Forsythia suspensa was placed in the steam generated by boiling ultrapure water heated in a pressurized environment, the steam temperature was controlled to 120°C, and the steam was sterilized for 12 minutes. The Forsythia suspensa after steam sterilization was dried, and the normal pressure environment was maintained. The drying temperature was maintained at 60°C, and the drying time was 20 minutes. After the drying was completed, the processed Forsythia suspensa was obtained.

[0027] Example 1.3 A processing technology for Fructus Forsythiae comprises the following steps: The crude Forsythia suspensa was placed in the steam generated by boiling ultrapure water heated in a pressurized environment, the steam temperature was controlled to 130°C, and the steam was sterilized for 10 minutes. The Forsythia suspensa after steam sterilization was dried, and the normal pressure environment was maintained. The drying temperature was maintained at 60°C, and the drying time was 20 minutes. After the drying was completed, the processed Forsythia suspensa was obtained.

[0028] Example 1.4 A processing technology for Fructus Forsythiae comprises the following steps: The crude Forsythia suspensa was placed in the steam generated by boiling ultrapure water heated in a pressurized environment, the steam temperature was controlled to 140°C, and the steam was sterilized for 10 minutes. The Forsythia suspensa after steam sterilization was dried, and the normal pressure environment was maintained. The drying temperature was maintained at 60°C and the drying time was 20 minutes. After the drying was completed, the processed Forsythia suspensa was obtained.

[0029] Example 1.5 A processing technology for Fructus Forsythiae comprises the following steps: The crude Forsythia suspensa was placed in the steam generated by boiling ultrapure water heated in a pressurized environment, the steam temperature was controlled to 135°C, and the steam was sterilized for 10 minutes. The Forsythia suspensa after steam sterilization was dried, and the normal pressure environment was maintained. The drying temperature was maintained at 60°C, and the drying time was 20 minutes. After the drying was completed, the processed Forsythia suspensa was obtained.

[0030] Example 2.1 A processing process for Forsythia suspensa, which is different from Example 1.5 in that the drying is reduced-pressure drying, specifically: placing the crude Forsythia suspensa in the steam generated by boiling ultrapure water heated in a pressurized environment, controlling the steam temperature to 135°C, steam sterilizing for 10 minutes, and reducing-pressure drying the Forsythia suspensa after steam sterilization, the pressure during drying is controlled at 0.05MPa, the drying temperature is controlled at 90°C, the drying time is 12 minutes, and the processed Forsythia suspensa is obtained after drying.

[0031] Example 2.2 A processing process for Forsythia suspensa, which is different from Example 1.5 in that the drying is reduced-pressure drying, specifically: placing the crude Forsythia suspensa in the steam generated by boiling ultrapure water heated in a pressurized environment, controlling the steam temperature to 135°C, steam sterilizing for 10 minutes, and reducing-pressure drying the Forsythia suspensa after steam sterilization, the pressure during drying is controlled at 0.1MPa, the drying temperature is controlled at 60°C, the drying time is 15 minutes, and the processed Forsythia suspensa is obtained after drying.

[0032] Example 3.1 A processing process for Forsythia suspensa, which is different from Example 2.1 in that the pressure reduction drying is carried out in three steps, specifically: placing the crude Forsythia suspensa in the steam generated by boiling ultrapure water heated in a pressurized environment, controlling the steam temperature to 135°C, steam sterilizing for 10 minutes, and then reducing the pressure to dry the Forsythia suspensa after steam sterilization, first controlling the pressure at 0.05MPa, the drying temperature at 90°C, drying for 5 minutes, then increasing the pressure by 0.02MPa, decreasing the temperature by 20°C, and drying for 5 minutes, and finally increasing the pressure to 0.1MPa, decreasing the temperature to 60°C, and drying for another 5 minutes, ending the drying to obtain the processed Forsythia suspensa.

[0033] Example 3.2 A processing process for Forsythia suspensa, which is different from Example 2.1 in that the pressure reduction drying is carried out in three steps, specifically: placing the crude Forsythia suspensa in the steam generated by boiling ultrapure water heated in a pressurized environment, controlling the steam temperature to 135°C, steam sterilizing for 10 minutes, and then reducing the pressure to dry the Forsythia suspensa after steam sterilization, first controlling the pressure at 0.05MPa, the drying temperature at 90°C, drying for 4 minutes, then increasing the pressure by 0.03MPa, decreasing the temperature by 10°C, and drying for 4 minutes, and finally increasing the pressure to 0.1MPa, decreasing the temperature to 60°C, and drying for another 4 minutes, ending the drying to obtain the processed Forsythia suspensa.

[0034] Example 3.3 A processing process for Forsythia suspensa, which is different from Example 2.1 in that the pressure reduction drying is carried out in three steps, specifically: placing the crude Forsythia suspensa in the steam generated by boiling ultrapure water heated in a pressurized environment, controlling the steam temperature to 135°C, steam sterilizing for 10 minutes, and then reducing the pressure to dry the Forsythia suspensa after steam sterilization, first controlling the pressure at 0.05MPa, the drying temperature at 90°C, drying for 5 minutes, then increasing the pressure by 0.025MPa, decreasing the temperature by 15°C, and drying for 5 minutes, and finally increasing the pressure to 0.1MPa, decreasing the temperature to 60°C, and drying for another 5 minutes, ending the drying to obtain the processed Forsythia suspensa.

[0035] Example 4.1 A processing process for Forsythia suspensa, which is different from Example 3.3 in that the crude Forsythia suspensa product is also refrigerated before steam-sterilization, specifically: the crude Forsythia suspensa product is refrigerated for 6 hours under normal pressure at a refrigeration temperature of 10°C, and then steam-sterilization is performed after the refrigeration treatment.

[0036] Example 4.2 A processing process for Forsythia suspensa, which is different from Example 3.3 in that the crude Forsythia suspensa product is also refrigerated before steam sterilization, specifically: the crude Forsythia suspensa product is refrigerated for 5 hours under normal pressure environment, the refrigeration temperature is 0°C, and steam sterilization is performed after the refrigeration treatment is completed.

[0037] Example 5 A Forsythia suspensa processing process, which is different from Example 4.1 in that the crude Forsythia suspensa product is further cleaned and washed before refrigeration treatment, specifically: the crude Forsythia suspensa product after removing impurities such as rotten fruits, shrunken fruits and fruit stalks is rinsed with running water for 5 minutes, and the rest is the same as Example 4.1.

[0038] Comparative Example 1 The difference from Example 1.1 is that the crude Forsythia suspensa is placed in boiling water to ensure that the weight ratio of the crude Forsythia suspensa to water is not greater than 1:6, and the Forsythia suspensa is boiled for 8 minutes. The Forsythia suspensa after boiling and killing is dried, and the normal pressure environment is maintained. The drying temperature is maintained at 60°C and the drying time is 20 minutes. After the drying is completed, the processed Forsythia suspensa is obtained.

[0039] Comparative Example 2 The difference from Example 1.1 is that the crude Forsythia suspensa is placed in the steam generated by boiling ultrapure water heated in a pressurized environment, the steam temperature is controlled to 150°C, the steam is sterilized for 8 minutes, the Forsythia suspensa after steam sterilization is exposed to sunlight all day, the air temperature is 29-40°C, the surface temperature is 35-66°C, and the processed Forsythia suspensa is obtained after the drying.

[0040] Comparative Example 3 The difference from Example 1.1 is that the steam temperature is controlled to be 180°C, and the rest is the same as Example 1.1.

[0041] Comparative Example 4 The difference from Example 1.1 is that the steam temperature is controlled to be 110° C., and the rest is the same as Example 1.1.

[0042] Performance Testing Weigh 1.000 g of each of the processed Forsythia samples obtained in the embodiment and the comparative example, add 10 mL of 80% ethanol by volume, grind and extract, transfer to a 25 mL volumetric flask, ultrasonically extract for 30 min, centrifuge (4000 r / min, 5 min), and dilute the supernatant with 80% ethanol. High pressure liquid chromatography (HPLC) is used to determine the concentrations of forsythiaside and forsythiaside A in the processed Forsythia, chromatographic column: Symmetry C18 (4.6 mm × 250 mm, 5 um); mobile phase: A is acetonitrile, B is 0.1% formic acid aqueous solution, and the gradient elution program is: 0-8 min, 8%-10% A; 8-24 min, 10%-15% A; 24-3 min, 15%-17% A; 30-40 min, 17%-30% A; 40-50 min, 30%-50% A; column temperature: 25°C; flow rate: 1.0 mL / min; detection wavelength: 280 nm; injection volume: 10 uL.

[0043] Prepare mixed standard stock solutions with a concentration of 2 g / L forsythiaside and forsythiaside A. Accurately pipette the stock solutions and dilute them into mixed standard solutions of 1000, 500, 250, 100, 50, and 10 mg / L, respectively. Perform HPLC determination under the above-mentioned chromatographic conditions, use the injection concentration (X, mg / L) as the abscissa and the peak area (Y, mv·s) as the ordinate to obtain the linear regression equation and draw the standard curve.

[0044] Table 1 Content of forsythiaside and forsythiaside A (%) Group Forsythiaside content (%) Forsythiaside A content (%) Example 1.1 0.78 2.65 Example 1.2 0.78 2.66 Example 1.3 0.79 2.68 Example 1.4 0.79 2.68 Example 1.5 0.79 2.72 Example 2.1 0.82 2.78 Example 2.2 0.82 2.79 Example 3.1 0.83 2.82 Example 3.2 0.83 2.82 Example 3.3 0.84 2.85 Example 4.1 0.85 2.88 Example 4.2 0.85 2.88 Example 5 0.86 2.90 Comparative Example 1 0.64 2.35 Comparative Example 2 0.60 2.24 Comparative Example 3 0.70 2.42 Comparative Example 4 0.71 2.49 Data Analysis: As can be seen from Table 1, the content of forsythiaside in the processed Forsythia obtained in Examples 1.1-1.2 reaches more than 0.78%, and the content of forsythiaside A reaches more than 2.65%, which proves that the high-temperature steam fixation in the present application can quickly kill the enzyme activity in the cells in a short time, prevent the effective ingredients from decomposing due to oxidation, and avoid the problem of water taking away the effective ingredients in the traditional water boiling process, significantly improve the retention rate of the effective ingredients in Forsythia, such as forsythiaside and forsythiaside A, thereby improving the overall quality and efficacy of Forsythia; The forsythin content and forsythiaside A content in the processed Forsythia of Examples 1.3-1.4 are higher than those in Examples 1.1-1.2, which proves that the present application can more effectively destroy the enzyme activity in Forsythia by precisely controlling the steam temperature at 130-140° C. and maintaining the steam killing time for 10 minutes, thereby reducing the decomposition of active ingredients such as forsythiaside and forsythiaside A, thereby significantly improving the active ingredient content of the processed Forsythia, which not only improves the efficacy of Forsythia, but also ensures the consistency and stability of its quality; The content of forsythiaside and forsythiaside A in the processed Forsythia of Example 1.5 is higher than that in Examples 1.1-1.4, which proves that the present application can further increase the content of forsythiaside and forsythiaside A in Forsythia by precisely controlling the steam temperature at 135°C and continuing the steam killing for 10 minutes, thereby improving the quality and efficacy of the processed Forsythia. This optimization measure can ensure that the active ingredients in Forsythia are retained to the maximum extent, reduce the loss of active ingredients caused by excessively high or low temperatures, and make the final product more stable and reliable. The content of forsythiaside and forsythiaside A in the processed Forsythiae of Examples 2.1-2.2 is higher than that in Example 1.5, which proves that the reduced-pressure drying method of the present application can reduce the influence of the external environment on the evaporation of water inside Forsythiae, thereby avoiding the destruction of effective ingredients caused by high temperature in the traditional drying process. The temperature-controlled and pressure-controlled drying process can maximize the stability and content of key bioactive substances such as forsythiaside and forsythiaside A while ensuring the drying of Forsythiae, thereby ensuring the quality and efficacy of Forsythiae medicinal materials; The forsythiaside content and forsythiaside A content in the processed Forsythiae of Examples 3.1-3.2 are higher than those in Example 2.1, which proves that the present application improves the stability and preservation of the final product by three times of pressure reduction drying. First, the pressure is controlled at 0.05MPa, the drying temperature is controlled at 90°C, and the drying is performed for 4-5min, so that the moisture on the surface of Forsythiae evaporates rapidly, reducing the loss of effective ingredients; then the pressure is increased by 0.02-0.03MPa, the temperature is decreased by 10-20°C, and the drying is performed for 4-5min, so as to further reduce the moisture content inside Forsythiae and avoid the damage of effective ingredients to high temperature; finally, the pressure is increased to 0.1MPa, the temperature is decreased to 60°C, and the drying is performed for another 4-5min, which not only reduces the loss of effective ingredients in Forsythiae, but also improves the quality and efficacy of Forsythiae after processing; The content of forsythiaside and forsythiaside A in the processed Forsythiae of Example 3.3 is higher than that of Example 3.1, which proves that the present application retains the key active ingredients such as forsythiaside and forsythiaside A to the maximum extent by strictly controlling the amplitude of blood pressure reduction and temperature reduction; The content of forsythin and forsythiaside A in the processed Forsythiae of Examples 4.1-4.2 is higher than that in Example 3.3, which proves that the crude Forsythiae of the present application is also refrigerated before steam fixation, which can effectively reduce the loss of effective ingredients such as forsythiaside and forsythiaside A in Forsythiae. The crude Forsythiae is refrigerated for 5-6 hours under normal pressure, and the refrigeration temperature is controlled within the range of 0-10°C, which can significantly inhibit the enzymatic hydrolysis reaction of the effective ingredients in Forsythiae, maintain its original biological activity, and thus improve the retention rate of these effective ingredients in the subsequent processing process; The forsythiaside content and forsythiaside A content in the processed Forsythia suspensa of Example 5 are higher than those in Example 4.1. The crude Forsythia suspensa was also cleaned and washed before refrigeration, which proves that this step of treatment in the present application can remove impurities and dirt, improve the purity of the raw materials, thereby reducing the impact of impurities on the extraction of effective ingredients in the subsequent processing process, and ensuring the quality and efficacy of the Forsythia suspensa after final processing; The content of forsythiaside and forsythiaside A in the processed Forsythiae of Comparative Example 1-2 is much lower than that in Example 1.1, which proves that the high-temperature steam fixation in the present application can quickly kill the enzyme activity in the cells in a short time, prevent the decomposition of the effective ingredients due to oxidation, and avoid the problem of water taking away the effective ingredients in the traditional water boiling process, significantly improve the retention rate of the effective ingredients in Forsythiae, such as forsythiaside and forsythiaside A, thereby improving the overall quality and efficacy of Forsythiae; The forsythiaside content and forsythiaside A content in the processed Forsythiae of Comparative Examples 3-4 are much lower than those in Example 1.1, which proves that the present application can further improve the retention rate of effective components by strictly controlling the temperature of steam sterilization.

[0045] The embodiments of this specific implementation method are all preferred embodiments of the present application, and are not intended to limit the protection scope of the present application. Therefore, all equivalent changes made based on the structure, shape, and principle of the present application should be included in the protection scope of the present application.

Claims

1. A process for processing Fructus Forsythiae, characterized in that: The following steps are involved: The crude Forsythia suspensa is placed in the steam generated by boiling ultrapure water heated in a pressurized environment, the steam temperature is controlled to be 120-150°C, the steam is sterilized for 8-12 minutes, and the Forsythia suspensa after steam sterilization is dried to obtain processed Forsythia suspensa.

2. The process for processing Fructus Forsythiae according to claim 1, characterized in that: The steam temperature is controlled at 130-140° C. and the steam sterilization is performed for 10 minutes.

3. The processing method of Forsythia suspensa according to claim 2, characterized in that: The steam temperature was controlled to be 135°C.

4. The process for processing Fructus Forsythiae according to claim 1, characterized in that: The drying is reduced-pressure drying, and the pressure during drying is controlled at 0.05-0.1 MPa, the drying temperature is controlled at 60-90° C., and the drying time is 12-15 min.

5. The process for processing Fructus Forsythiae according to claim 4, characterized in that: The decompression drying is carried out in three steps, specifically: First, control the pressure at 0.05MPa and the drying temperature at 90℃, and dry for 4-5min. Then increase the pressure by 0.02-0.03MPa, reduce the temperature by 10-20℃, and dry for 4-5min. Finally, increase the pressure to 0.1MPa, reduce the temperature to 60℃, and dry for another 4-5min to end the drying.

6. The process for processing Fructus Forsythiae according to claim 5, characterized in that: The decompression drying is specifically: First, the pressure is controlled at 0.05MPa, the drying temperature is controlled at 90℃, and the drying is carried out for 4-5min. Then, the pressure is increased by 0.025MPa, the temperature is decreased by 15℃, and the drying is carried out for 4-5min. Finally, the pressure is increased to 0.1MPa, the temperature is decreased to 60℃, and the drying is carried out for another 4-5min to end the drying.

7. The process for processing Fructus Forsythiae according to claim 1, characterized in that: The crude Forsythia suspensa product is also subjected to a refrigeration treatment before steam killing, specifically: the crude Forsythia suspensa product is refrigerated for 5-6 hours under normal pressure, and the refrigeration temperature is 0-10°C.

8. The process for processing Fructus Forsythiae according to claim 7, characterized in that: The crude Forsythia suspensa product is further cleaned and washed before being refrigerated.

9. A processed Fructus Forsythiae obtained by the processing method of Fructus Forsythiae according to any one of claims 1 to 8, characterized in that: The content of forsythiaside in the processed Fructus Forsythiae is ≥0.78%, and the content of forsythiaside A is ≥2.65%.