Gastric mucus-imitating weak acidification anti-seepage deoxidizing inhibitor and preparation method thereof

Abstract

The invention belongs to the technical field of coal spontaneous combustion inhibitors, and particularly relates to a stomach mucus-imitating weak acidification anti-seepage oxygen removal inhibitor and a preparation method thereof. Comprising viscous fluid, and the viscous fluid is prepared from malic acid, glucose, sodium alginate, inorganic salt and glucose oxidase. After the raw materials are stirred, CO2 is introduced to prepare the stopping agent. Based on the bionics principle, the inhibitor system capable of shielding oxygen in multiple ways is constructed; according to the inhibitor, the defect that a water-soluble inhibitor needs to be sprayed repeatedly can be overcome, the dosage is small, the inhibition time is prolonged to a certain degree, and the coal-oxygen compounding effect can be further reduced while the inhibition efficiency is guaranteed.

Description

Technical Field

[0001] The invention belongs to the technical field of coal spontaneous combustion inhibitors and relates to a gastric mucus-simulating weakly acidifying anti-seepage and deoxidation inhibitor and a preparation method thereof. Background Art

[0002] There are various safety risks in the process of coal mining, transportation, storage, etc., and the prevention and control of coal spontaneous combustion plays a very important role. At the same time, coal spontaneous combustion is also the cause of other mine disasters and accounts for a large part of the major accidents in coal mines. With the development of science and technology, the means of preventing and controlling coal spontaneous combustion have become diversified, among which inhibitors are a very effective method of fire prevention and extinguishing.

[0003] Physical inhibitors show good performance in the early stage of coal spontaneous combustion, but they generally need to be sprayed repeatedly, consume a large amount of materials, and some salt inhibitors promote coal spontaneous combustion in the later stage. Many researchers have selected reduced glutathione, resveratrol, etc. as antioxidant inhibitors. The inhibition mechanism of these antioxidants is mostly based on the removal of free radicals on the surface of coal, which does not fundamentally solve the problem. With the development of science and technology, coal spontaneous combustion prevention and control measures have become diversified, but shielding oxygen is still a common attribute of most methods. Some scholars have developed deoxidation inhibitors based on this and used Fe powder as an oxygen consuming agent, but this inhibitor still cannot overcome the disadvantage of a short action time. At the same time, the presence of iron will promote the low-temperature oxidation rate of coal and is easily affected by its own particle size and state. Summary of the invention

[0004] The present invention overcomes the shortcomings of the prior art and proposes a gastric mucus-like weakly acidified anti-seepage and deoxidation inhibitor and a preparation method thereof; based on the bionics principle, the principle that gastric mucosa and gastric mucus have a protective effect on the stomach wall is applied to the inhibitor, aiming to coordinate and unify multiple ways to prevent coal spontaneous combustion and construct an inhibitor system that can shield oxygen in multiple ways. The present invention is achieved through the following technical solutions.

[0005] A gastric mucus-simulating weakly acidifying anti-seepage and deoxidizing inhibitor comprises a viscous fluid, wherein the mass percentage concentration of raw materials in the viscous fluid is: malic acid: 0.001wt%~0.004wt%, glucose: 20wt%~30wt%, sodium alginate: 1.5wt%~2.5wt%, inorganic salt: 0.075%~0.225wt%, and glucose oxidase; the mass ratio of glucose to glucose oxidase is 80~120:1.

[0006] Preferably, the mass percentage concentrations of the raw materials in the viscous fluid are: malic acid: 0.004wt%, glucose: 25wt%, sodium alginate: 2wt%, inorganic salt: 0.225wt%, and glucose oxidase; the mass ratio of glucose to glucose oxidase is 100:1.

[0007] Preferably, 400 ml to 600 ml of CO2 is introduced into every 200 ml of viscous fluid.

[0008] Preferably, the malic acid is DL-malic acid.

[0009] Preferably, the inorganic salt is sodium chloride, calcium chloride or magnesium chloride.

[0010] More preferably, the inorganic salt is magnesium chloride.

[0011] A method for preparing a gastric mucus-simulating weakly acidifying anti-seepage and deoxidizing inhibitor is provided. The method comprises the following steps: measuring 200 ml of 2wt% sodium alginate viscous fluid, adding 0.45 g of inorganic salt, 5 g of glucose, 0.05 g of glucose oxidase, and 0.004 g of malic acid respectively, stirring for ten minutes, and then introducing 500 ml of CO2.

[0012] Preferably, the malic acid is DL-malic acid, and the inorganic salt is magnesium chloride.

[0013] The beneficial effects of the present invention compared with the prior art are as follows: 1. The present invention is based on the principle of bionics, drawing on the principle that gastric mucosa and gastric mucus have a protective effect on the stomach wall, that is, the gastric mucosa can form a dense layer on the surface of the stomach wall to reduce the contact between the stomach wall and gastric acid or its irritant. If gastric acid or other irritants enter the stomach wall, the gastric mucus secreted by the gastric mucosa can also quickly absorb and neutralize them, maintain the pH at a normal level, and protect the stomach wall from damage. This protective mechanism is associated with the inhibitor for preventing coal spontaneous combustion, and a new oxygen-consuming inhibitor system is constructed.

[0014] 2. The present invention utilizes the dense layer formed by the sodium alginate viscous fluid on the coal surface to reduce the collision between coal and oxygen molecules. If oxygen penetrates the dense layer to oxidize the coal, glucose oxidase immediately catalyzes the oxidation of glucose to consume the infiltrated oxygen. Glucose, as a polysaccharide, will not affect the subsequent use of coal, nor will it catalyze the oxidation of coal. In addition, in the early stage of the inhibitor action, the oxygen consumption reaction of the present invention is more intense than that of the iron powder system.

[0015] 3. The present invention utilizes Mg in the catalyst 2+ DL-malic acid can complex with N, S, etc. in coal, and can weaken the catalytic effect of metal ions on coal spontaneous combustion and the generation of free radicals in coal, further weakening the occurrence of coal-oxygen complex reaction. Adding carbon dioxide to the sodium alginate viscous fluid can further reduce the concentration of oxygen, thereby achieving the effect of inertization and inhibition.

[0016] In summary, the present invention is based on the principle of bionics, and applies the protective effect of gastric mucosa and gastric mucus on the stomach wall to the inhibitor, aiming to coordinate and unify multiple ways to prevent coal spontaneous combustion, and construct an inhibitor system that can shield oxygen in multiple ways. An oxygen-consuming agent, a catalyst, a thickener, a supplement, and an inertizing agent are combined to prepare a gastric mucus-like weakly acidified anti-seepage and deoxidizing inhibitor. This inhibitor can overcome the disadvantage that water-soluble inhibitors need to be sprayed repeatedly, and the dosage is small, which prolongs the inhibition time to a certain extent, and can further reduce the coal-oxygen complex while ensuring the inhibition efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a schematic diagram of the preparation process of the weakly acidifying anti-seepage and deoxidation inhibitor described in the present invention.

[0018] Figure 2 The figure is a graph of oxygen consumption at 41°C when different mass ratios of glucose and glucose oxidase are added in the present invention; wherein group A1 is added with 5g glucose and 10mg glucose oxidase, group A2 is added with 5g glucose and 30mg glucose oxidase, group A3 is added with 5g glucose and 50mg glucose oxidase, group A4 is added with 5g glucose and 70mg glucose oxidase, and group A5 is added with 5g glucose and 100mg glucose oxidase.

[0019] Figure 3 The present invention adds different masses and types of inorganic salts, 5g glucose and 50mg glucose oxidase at 41°C and shows the extreme difference in oxygen consumption rules of each experimental group.

[0020] Figure 4 The oxygen consumption rules of different masses of sodium alginate, 0.45 g of magnesium chloride, 5 g of glucose and 50 mg of glucose oxidase at 41° C. were investigated in the present invention.

[0021] Figure 5 The oxygen consumption rules of each experimental group at 41° C. are shown in the present invention when 0.45 g magnesium chloride, 5 g glucose, 50 mg glucose oxidase and different masses of DL-malic acid are added to 200 ml of 2 wt % sodium alginate.

[0022] Figure 6 The present invention adds 0.45g magnesium chloride, 5g glucose, 50mg glucose oxidase, 0.004DL-malic acid to 200ml 2wt% sodium alginate and passes different volumes of carbon dioxide into the experimental groups at room temperature (16°C) to observe the oxygen consumption patterns. DETAILED DESCRIPTION

[0023] In order to make the technical problems, technical solutions and beneficial effects to be solved by the present invention clearer, the present invention is further described in detail in conjunction with the embodiments and the accompanying drawings. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention. The technical solutions of the present invention are described in detail below in conjunction with the embodiments and the accompanying drawings, but the scope of protection is not limited thereto.

[0024] The present invention provides a gastric mucus-simulating weakly acidifying anti-seepage and deoxidizing inhibitor and a preparation method thereof. The inhibitor is divided into five parts: an oxygen consuming agent, a catalyst, a thickener, a supplement, and an inertizing agent. Since the work of preventing coal spontaneous combustion focuses on the slow oxidation stage of coal, the critical point of this stage depends on the type of coal, but generally does not exceed 60-80°C. The actual working temperature in the mine generally does not exceed 32°C, but the heat released by the oxidation of coal itself will increase the ambient temperature, so that the ambient temperature reaches 35°C. Therefore, when selecting the content of the specific components of each part, the temperature is selected to be 41°C. The following Examples 1-10 clarify the preferred types and contents of oxygen consuming agents, catalysts, thickeners, supplements, and inertizing agents.

[0025] It should be noted that: Sodium alginate is a natural polysaccharide that is non-toxic and forms a viscous liquid when dissolved in water. It has excellent heat resistance, moisture retention, and flame retardancy, and meets the application conditions under mines. Therefore, the present invention selects sodium alginate as a thickener, which functions to form a dense layer on the surface of coal, reduce the contact between coal and oxygen, and aims to simulate the environment of gastric mucus and gastric mucosa, and play an oxygen-isolating and oxygen-blocking effect.

[0026] Some scholars have used iron powder as the main oxygen-consuming agent to conduct research, but the inhibitory effect of iron powder is easily affected by its own particle size and byproducts produced in the process, and the reaction of iron powder with water will produce hydrogen, which will affect environmental safety. Therefore, the present invention selects an environmentally friendly reagent - glucose. Glucose is a simple monosaccharide that is widely present in nature and is inexpensive. In addition, glucose oxidase can catalyze the oxidation of glucose at room temperature. The presence of the oxygen-consuming agent can consume the oxygen that penetrates into the dense layer, further preventing coal from contacting oxygen, and achieving the oxygen-consuming effect required by the new inhibitor system.

[0027] Magnesium ions have a catalytic effect on glucose oxidase, and its specific mechanism of action is to purify some impurity proteins, so that the content of some small molecule proteins that work in glucose oxidase is higher. At the same time, magnesium chloride is a common and effective physical inhibitor. Therefore, the present invention selects magnesium chloride as a catalyst.

[0028] Since the optimal activity pH of glucose oxidase is 3.5-6.5, weak acidic substances are preferably selected as supplements. Malic acid (also known as 2-hydroxysuccinic acid) is an organic acid widely present in nature. It is divided into L-malic acid, D-malic acid and a mixture of DL-malic acid. It is a biodegradable substance and will not cause long-term ecological pollution to the underground environment. These three different configurations of malic acid have antioxidant and chelating properties; DL-malic acid can form stable complexes with metals in coal to reduce the catalytic effect of metals on coal spontaneous combustion, and can also inhibit the generation of free radicals in coal and have a good antibacterial effect. It can be used to prevent and control coal spontaneous combustion. In addition, DL-malic acid can also be obtained through industrial synthesis. Therefore, this study selected DL-malic acid as a supplement for the new inhibitor. The toxicity of DL-malic acid is related to its added concentration. As a supplement in the gastric mucus-like weak acidification anti-seepage and deoxidation inhibitor system, the added amount is small, so the toxicity is very weak.

[0029] The inert agent needs to release inert gas under certain conditions in order to further reduce the O2 content. Since the glucose oxidase added in this article prefers an acidic environment, CO2 is selected as the inert agent.

[0030] The technical scheme adopted by the present invention is: a gastric mucus-simulating weakly acidified anti-seepage and deoxidation inhibitor, the components of which are magnesium chloride, glucose, glucose oxidase, sodium alginate, DL-malic acid, carbon dioxide and solvent water.

[0031] The inhibition principle adopted by the present invention is: the sodium alginate viscous fluid forms a dense layer on the surface of the coal, reducing the collision between the coal and oxygen molecules. If oxygen penetrates the dense layer to oxidize the coal, the glucose oxidase immediately catalyzes the oxidation of glucose to consume the infiltrated oxygen. In addition, the Mg in the catalyst 2+ DL-malic acid can complex with N, S, etc. in coal, and can weaken the catalytic effect of metal ions on coal spontaneous combustion and the generation of free radicals in coal, further weakening the occurrence of coal-oxygen complex reaction. Adding carbon dioxide to the sodium alginate viscous fluid can further reduce the concentration of oxygen, thereby achieving the effect of inertization and inhibition.

[0032] The oxygen consumption principle adopted by the present invention is as follows: Example 1 A preparation process of an oxygen-consuming agent in a gastric mucus-simulating weakly acidifying anti-seepage and deoxidizing inhibitor: (1) Measure 200 ml of deionized water, add 5 g of glucose and stir evenly, then add 0.01 g of glucose oxidase and stir evenly to obtain group A1.

[0033] (2) Measure 200 ml of deionized water, add 5 g of glucose and stir evenly, then add 0.03 g of glucose oxidase and stir evenly to obtain group A2.

[0034] (3) Measure 200 ml of deionized water, add 5 g of glucose and stir evenly, then add 0.05 g of glucose oxidase and stir evenly to obtain group A3.

[0035] (4) Measure 200 ml of deionized water, add 5 g of glucose and stir evenly, then add 0.07 g of glucose oxidase and stir evenly to obtain group A4.

[0036] (5) Measure 200 ml of deionized water, add 5 g of glucose and stir evenly, then add 0.1 g of glucose oxidase and stir evenly to obtain group A5.

[0037] Example 2 The oxygen content in the reaction container of (1)-(5) in the above Example 1 was tested using a dissolved oxygen meter, and it was ensured that all conditions except the amount of glucose oxidase used were the same during the experiment. The temperature of each group of experiments was adjusted by a water bath, the temperature was set at 45°C, and the temperature in the reaction container was actually 41°C. The oxygen content of the solution to be tested was measured every 5 minutes and recorded continuously for 95 minutes. The results are as follows: Figure 2 As shown. In 0-5 minutes, the oxygen consumption of group A3 was the fastest, and then the oxygen content of group A3 was the lowest, until the oxygen content of group A4 became the lowest at 22 minutes. The oxygen content of A1 and A2 reached 0.04 mg / ml at 30 minutes and 25 minutes respectively and was maintained, and A5 reached 0.06 mg / ml at 75 minutes and was maintained. In 22-60 minutes, although A4 was slightly faster than A3, the oxygen content of both reached 0.01 at 60 minutes. Taking into account the oxygen consumption effect and the amount of reagents used, the present invention selects 25wt% glucose solution and 50mg (i.e., group A3) enzyme as the oxygen consumption component of the new inhibitor.

[0038] Example 3 A preparation process of a catalyst in a gastric mucus-simulating weakly acidified anti-seepage and deoxidation inhibitor: Measure 200 ml of deionized water, add inorganic salts of different masses and types, add 5 g of glucose and stir evenly, then add 0.03 g of glucose oxidase and stir evenly.

[0039] Example 4 The oxygen content in the reaction vessel of the above embodiment 3 was tested with a dissolved oxygen meter, and it was ensured that the conditions other than the type and content of inorganic salts were the same during the experiment. The temperature of each group of experiments was adjusted by a water bath, and the temperature was set at 45°C. The temperature in the reaction vessel was actually 41°C. The experiment was considered to be over when the oxygen concentration reached 0.09. Since the best catalyst and dosage could not be selected by simply looking at the result of oxygen consumption time, the range of this group of data was calculated, and the range was used to characterize the significance of the factors affecting the results. The results are shown in the figure. Figure 3 As shown. Figure 3It can be seen that the degree of change of CaCl2 with dosage is the smallest. When 0.15g of CaCl2 is added, the oxygen consumption time is the shortest, followed by 0.45g of MgCl2. Although CaCl2 is the best choice in terms of influence and oxygen consumption time, CaCl2 is easily affected by carbonates in the environment, and the traditional inhibitor MgCl2 has better inhibitory effect than CaCl2, so 0.45g of MgCl2 is selected as the catalyst.

[0040] Example 5 A preparation process of a thickener in a gastric mucus-simulating weakly acidified anti-seepage and deoxidation inhibitor: (1) Measure 198 ml of deionized water, add 2 g of sodium alginate, and stir with a mechanical stirrer until the sodium alginate is completely dissolved in the water. Let it stand to obtain a 1 wt% sodium alginate viscous fluid. Then add 0.45 g of magnesium chloride, 5 g of glucose, and 0.05 g of glucose oxidase, and stir for ten minutes to obtain group B1.

[0041] (2) Measure 197 ml of deionized water, add 3 g of sodium alginate, and stir with a mechanical stirrer until the sodium alginate is completely dissolved in the water. Let it stand to obtain a 1.5 wt% sodium alginate viscous fluid. Then add 0.45 g of magnesium chloride, 5 g of glucose, and 0.05 g of glucose oxidase, stir for half an hour, and obtain group B2.

[0042] (3) Measure 196 ml of deionized water, add 4 g of sodium alginate, and stir with a mechanical stirrer until the sodium alginate is completely dissolved in the water. Let it stand to obtain a 2 wt% sodium alginate viscous fluid. Then add 0.45 g of magnesium chloride, 5 g of glucose, and 0.05 g of glucose oxidase, stir for half an hour, and obtain group B3.

[0043] (4) Measure 195 ml of deionized water, add 5 g of sodium alginate, and stir with a mechanical stirrer until the sodium alginate is completely dissolved in the water. Let it stand to obtain a 2.5 wt% sodium alginate viscous fluid. Then add 0.45 g of magnesium chloride, 5 g of glucose, and 0.05 g of glucose oxidase, stir for half an hour, and obtain group B4.

[0044] Example 6 The oxygen content in the reaction container of (1)-(4) in the above Example 5 was tested using a dissolved oxygen meter, and it was ensured that all conditions except the concentration of the sodium alginate solution were the same during the experiment. The temperature of each group of experiments was adjusted by a water bath, and the temperature was set at 45°C. The temperature in the reaction container was actually 41°C. The measurement was performed every 30 minutes for 24 hours. The results were as follows: Figure 4. B1 reached the lowest point of 0.5mg / ml at 0.5h and then immediately rose, and finally fluctuated around 0.75mg / ml; B2 reached the lowest point of 0.01mg / ml at 2.5h and maintained for 6h before rising, and finally fluctuated around 0.5mg / ml; B3 reached the lowest point of 0.01mg / ml at 3h and maintained the lowest point; B4 reached the lowest point of 0mg / ml at 4.5h and then immediately rose, and finally fluctuated around 0.55mg / ml. Therefore, the present invention selects 2wt% sodium alginate as a thickener.

[0045] Example 7 A preparation process of a supplement in a gastric mucus-simulating weakly acidifying anti-seepage and deoxidizing inhibitor: (1) Measure 200 ml of 2 wt% sodium alginate viscous fluid, add 0.45 g of magnesium chloride, 5 g of glucose, and 0.05 g of glucose oxidase respectively, and stir for ten minutes to obtain group C1.

[0046] (2) Measure 200 ml of 2 wt% sodium alginate viscous fluid, add 0.45 g magnesium chloride, 0.002 g DL-malic acid, 5 g glucose, and 0.05 g glucose oxidase respectively, and stir for ten minutes to obtain group C2.

[0047] (3) Measure 200 ml of 2 wt% sodium alginate viscous fluid, add 0.45 g magnesium chloride, 0.006 g DL-malic acid, 5 g glucose, and 0.05 g glucose oxidase respectively, and stir for ten minutes to obtain group C3.

[0048] (4) Measure 200 ml of 2 wt% sodium alginate viscous fluid, add 0.45 g magnesium chloride, 0.008 g DL-malic acid, 5 g glucose, and 0.05 g glucose oxidase respectively, and stir for ten minutes to obtain group C4.

[0049] (5) Measure 200 ml of 2 wt% sodium alginate viscous fluid, add 0.45 g magnesium chloride, 0.010 g DL-malic acid, 5 g glucose, and 0.05 g glucose oxidase respectively, and stir for ten minutes to obtain group C5.

[0050] Example 8 The oxygen content in the reaction container of (1)-(5) in the above Example 7 was tested using a dissolved oxygen meter, and it was ensured that all conditions except the concentration of the sodium alginate solution were the same during the experiment. The temperature of each group of experiments was adjusted by a water bath, and the temperature was set at 45°C. The temperature in the reaction container was actually 41°C. The measurement was performed every 30 minutes for 24 hours. The results were as follows: Figure 5Compared with group C1, group C2 had a higher minimum oxygen content and a longer minimum oxygen content duration, and its oxygen content was higher than group C1 in 9.5h-24h. Group C3 had a lower oxygen content than group C1 in 1.2h-2.5h, and its minimum oxygen content was consistent with group C1, but its duration was shorter, and it was slightly higher than group C1 in the oxygen content rising stage (i.e., 6.5h-24h). Group C4 had a lower oxygen content than group C1 in 9.5h-18.5h, and maintained its minimum oxygen content for 0.5h longer than the control group, and its final oxygen content was only slightly higher than group C1. Group C5 had a higher oxygen content than group C1 throughout the whole process. The oxygen content of groups C2-C5 was mostly higher than that of group C1 in the oxygen content rising stage, which may be because as the reaction occurred, the environment in the container was out of the pH value with the highest GOX activity. Taking into account the maintenance time of the minimum oxygen content and the difference between the oxygen content change at each time point and C1, group C4 (containing 0.008 g DL-malic acid) was selected as the final formula of the present invention.

[0051] Example 9 A preparation process of an inertizing agent in a gastric mucus-simulating weakly acidifying anti-seepage and deoxidizing inhibitor: (1) Take 200 ml of 2 wt% sodium alginate viscous fluid, add 0.45 g of magnesium chloride, 5 g of glucose, 0.05 g of glucose oxidase, and 0.004 g of DL-malic acid, respectively, stir for ten minutes, and then pass 100 ml of CO2 to obtain group D1.

[0052] (2) Take 200 ml of 2 wt% sodium alginate viscous fluid, add 0.45 g of magnesium chloride, 5 g of glucose, 0.05 g of glucose oxidase, and 0.004 g of DL-malic acid, respectively, stir for ten minutes, and then introduce 300 ml of CO2 to obtain group D2.

[0053] (3) Take 200 ml of 2 wt% sodium alginate viscous fluid, add 0.45 g of magnesium chloride, 5 g of glucose, 0.05 g of glucose oxidase, and 0.008 g of DL-malic acid, respectively, stir for ten minutes, and then introduce 500 ml of CO2 to obtain group D3.

[0054] Example 10 The oxygen content in the reaction vessel of (1) to (3) in the above Example 9 was tested using a dissolved oxygen meter, and all other conditions except the amount of carbon dioxide introduced were kept the same during the experiment. The test was performed every 30 minutes for 12 hours. The results were as follows: Figure 6 Overall, the D3 group was significantly lower than the other two groups, so the D3 group (containing 500 ml of carbon dioxide) was selected as the final formula of the present invention: A gastric mucus-simulating weakly acidifying anti-seepage and deoxidizing inhibitor comprises a viscous fluid, wherein the mass percentage concentration of raw materials in the viscous fluid is: 0.004wt% DL malic acid, 25wt% glucose, 2wt% sodium alginate, 0.225wt% magnesium chloride, and glucose oxidase; the mass ratio of glucose to glucose oxidase is 100:1; 500ml CO2 is introduced into every 200ml of the viscous fluid.

[0055] The above content is a further detailed description of the present invention in combination with a specific preferred embodiment. It cannot be determined that the specific embodiments of the present invention are limited to this. For ordinary technicians in the technical field to which the present invention belongs, several simple deductions or substitutions can be made without departing from the present invention, which should be regarded as belonging to the present invention and the scope of patent protection determined by the submitted claims.

Claims

1. A gastric mucus-simulating weak acidification anti-seepage and deoxidation inhibitor, characterized in that: The invention comprises a viscous fluid, wherein the mass percentage concentration of raw materials in the viscous fluid is: malic acid: 0.001wt%~0.004wt%, glucose: 20wt%~30wt%, sodium alginate: 1.5wt%~2.5wt%, inorganic salt: 0.075%~0.225wt%, and glucose oxidase; the mass ratio of glucose to glucose oxidase is 80~120:

1.

2. The gastric mucus-simulating weakly acidifying anti-seepage and deoxidizing inhibitor according to claim 1, characterized in that: The mass percentage concentrations of the raw materials in the viscous fluid are: malic acid: 0.004wt%, glucose: 25wt%, sodium alginate: 2wt%, inorganic salt: 0.225wt%, and glucose oxidase; the mass ratio of glucose to glucose oxidase is 100:

1.

3. A gastric mucus-simulating weakly acidifying anti-seepage and deoxidizing inhibitor according to claim 1 or 2, characterized in that: 400ml~600ml of CO2 is introduced into every 200ml of viscous fluid.

4. A gastric mucus-simulating weakly acidifying anti-seepage and deoxidation inhibitor according to claim 1 or 2, characterized in that: The malic acid is DL-malic acid.

5. A gastric mucus-simulating weakly acidifying anti-seepage and deoxidizing inhibitor according to claim 1 or 2, characterized in that: The inorganic salt is sodium chloride, calcium chloride or magnesium chloride.

6. The gastric mucus-simulating weakly acidifying anti-seepage and deoxidizing inhibitor according to claim 5, characterized in that: The inorganic salt is magnesium chloride.

7. The method for preparing a gastric mucus-simulating weakly acidifying anti-seepage and deoxidation inhibitor as claimed in claim 3, characterized in that: Take 200 ml of 2 wt% sodium alginate viscous fluid, add 0.45 g of inorganic salt, 5 g of glucose, 0.05 g of glucose oxidase, and 0.008 g of malic acid respectively, stir for ten minutes, and then introduce 500 ml of CO2.

8. The method for preparing a gastric mucus-simulating weakly acidifying anti-seepage and deoxidizing inhibitor as claimed in claim 7, characterized in that: The malic acid is DL-malic acid, and the inorganic salt is magnesium chloride.

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