A desktop integrated machine for low-temperature filling, stoppering and capping of vials

Abstract

The present invention relates to a desktop-type low-temperature filling, stoppering and capping integrated machine for syringe bottles, comprising a material sorting and loading mechanism, a filling mechanism, a step-by-step track transmission mechanism, a stoppering and capping mechanism, a capping and dust collection mechanism, a material discharge mechanism, a waste discharge box, and an equipment chassis; the equipment chassis is desktop-type, the material sorting and loading mechanism is used to adjust the positions of syringe bottles and transmit them to the step-by-step track transmission mechanism; the filling mechanism is used to fill the syringe bottles on the step-by-step track transmission mechanism with raw materials; the stoppering and capping mechanism is used to add rubber stoppers and aluminum caps to the syringe bottles; the capping and dust collection mechanism is used to cap the syringe bottles and absorb aluminum chips generated during the capping process; the material discharge mechanism is used to screen and collect syringe bottles that have passed the filling process, and the waste discharge box is used to collect syringe bottles that have failed the filling process.

Description

Technical Field

[0001] The invention relates to the technical field of vial filling, in particular to a desktop type vial low-temperature filling, stoppering and capping integrated machine. Background Art

[0002] Currently, most filling, stoppering, and capping machines on the market are vertical, occupying a large footprint and requiring custom isolators depending on the application scenario. To prevent aluminum shavings from the capping process from contaminating the production environment and the drug, filling, stoppering, and capping processes are performed on separate production lines. This reduces production efficiency and increases space requirements, presenting certain limitations. The filling equipment lacks a low-temperature mixing module, making it unable to meet the need for low-temperature solution storage during the filling process. Currently, low-temperature filling in an isolator typically requires an external cryogenic device, which transfers the solution to the isolator via an aseptic material transfer system for filling. However, this material transfer system is disposable and expensive. Furthermore, during the later stages of low-temperature filling, the solution significantly decreases, making mixing difficult. Existing filling equipment can only meet the filling needs of a single specification and cannot meet the needs of filling multiple specifications and models. Filling equipment often requires an external air source, where air expands in the cylinder, converting thermal energy into mechanical energy. If used in an isolator, the accompanying isolator must have a port for an external air source. If the isolator has no reserved opening, drilling is required, which may damage the isolator's pressure protection system, sealed airflow system, etc. Summary of the Invention

[0003] The present invention provides a desktop-type low-temperature filling, stoppering and capping integrated machine for vials, comprising a material sorting and loading mechanism, a filling mechanism, a stepping track transmission mechanism, a stoppering and capping mechanism, a capping and dust collection mechanism, a material unloading mechanism, a waste discharge box, and an equipment chassis; the equipment chassis is desktop-type, and the material sorting and loading mechanism, the filling mechanism, the stepping track transmission mechanism, the stoppering and capping mechanism, the capping and dust collection mechanism, the material unloading mechanism, and the waste discharge box are all arranged above the equipment chassis;

[0004] The material sorting and loading mechanism is used to adjust the position of the vials and transmit them to the step-by-step track transmission mechanism; the filling mechanism is used to fill the vials on the step-by-step track transmission mechanism with raw materials; the stoppering and capping mechanism is used to add rubber stoppers and aluminum caps to the vials; the capping and dust collection mechanism is used to cap the vials and absorb aluminum chips generated during the capping process; the unloading mechanism is used to screen and collect vials that have passed the filling process, and the waste discharge box is used to collect vials that have failed the filling process.

[0005] Furthermore, the stepping track transmission mechanism includes a product conveying and positioning track, a quick-change conveying claw, a conveying servo module, and an avoidance electric cylinder module;

[0006] The transport servo module drives the avoidance electric cylinder module to move back and forth in a first direction. The avoidance electric cylinder module is fixedly connected to the quick-change transport claw and drives the quick-change transport claw to move back and forth in a second direction.

[0007] The quick-change transport claw is provided with a plurality of semicircular grooves matching the vial body, and the vial is transported from the material sorting and loading mechanism to the product conveying and positioning track by the quick-change transport claw;

[0008] The first direction is the conveying direction of the vial on the product conveying and positioning track; the second direction is perpendicular to the first direction and parallel to the plane of the product conveying and positioning track.

[0009] Furthermore, the stoppering and capping mechanism includes a stopper vibrating plate, an aluminum cover vibrating plate, and a stopper and aluminum cover transplanting mechanism. The stopper vibrating plate is provided with a stopper conveying trough and a stopper discharge port. The aluminum cover vibrating plate is provided with an aluminum cover conveying trough and an aluminum cover discharge port. The stopper and aluminum cover transplanting mechanism is provided with a stopper clamp and an aluminum cover clamp.

[0010] Furthermore, the rubber stopper discharge port and the aluminum cover discharge port are on one processed part.

[0011] Furthermore, the capping dust suction mechanism includes a capping cutter head, a dust suction device, and a capping sealing device. The capping sealing device includes a stainless steel capping cover and a transition joint. The dust suction device includes a dust suction device outer cover, a dust suction device upper cover, a dust suction fan, and a filter element. The stainless steel capping cover and the transition joint are fixedly connected by threads to form a cavity for accommodating the cap part of the vial. The capping cutter head is located inside the cavity. The stainless steel capping cover and the capping cutter head can move up and down synchronously. The transition joint is provided with an interface connected to the dust suction device, thereby connecting the dust suction device with the cavity.

[0012] Furthermore, the stainless steel capping cover is fixed on the capping lifting shaft. When the capping lifting shaft descends, the stainless steel capping cover and the transition joint wrap the capping cutter head and move downward at the same time, and the cap of the vial partially enters the cavity. When the capping lifting shaft rises, the cap of the vial partially exits the cavity.

[0013] Furthermore, when the capping cutter head is working, the dust suction device is turned on to suck the aluminum chips generated by capping into the filter element through the pipeline.

[0014] Furthermore, the all-in-one machine also includes a stock solution low-temperature mixing device, which is used to mix and control the temperature of the stock solution to be filled;

[0015] The raw liquid low-temperature mixing equipment includes a refrigeration plate, an outer frame, and a reciprocating extrusion device. The reciprocating extrusion device includes: a roller assembly and a rocking arm. The rocking arm includes a first rocking plate and a second rocking plate arranged opposite to each other. The roller assembly includes three rollers arranged in the upper, middle and lower parts, and three bearings respectively passing through the three rollers. Gaskets are provided on both sides of the three rollers. The two ends of the bearings of the upper roller and the lower roller are fixedly connected to the gaskets. The two ends of the bearing of the middle roller pass through the gaskets on both sides and are respectively fixedly connected to the front ends of the first rocking plate and the second rocking plate; the rear ends of the first rocking plate and the second rocking plate are connected to the driving mechanism on the back of the outer frame, and the driving mechanism can drive the first rocking plate and the second rocking plate to swing back and forth around the axis.

[0016] Furthermore, the raw liquid low-temperature mixing equipment also includes an extrusion head assembly, which is arranged at the lower part of the refrigeration plate. The extrusion head assembly includes a plurality of extrusion heads, and the plurality of extrusion heads can extend and retract relative to the outer surface of the refrigeration plate.

[0017] Furthermore, the filling mechanism includes a peristaltic pump, upper and lower follower filling heads, and a weighing sensor. The peristaltic pump is connected to the raw liquid low-temperature mixing equipment and is used to transfer the raw liquid to the upper and lower follower filling heads. The upper and lower follower filling heads are used to fill the raw liquid into the syringe bottle. The weighing sensor is used to weigh the syringe bottle before and after filling.

[0018] The present invention has the following technical effects: (1) The equipment chassis is desktop-type, and the material handling and loading mechanism, filling mechanism, step-by-step rail transmission mechanism, plugging and capping mechanism, capping and dust collection mechanism, unloading mechanism, and waste discharge box are all arranged above the equipment chassis, thereby forming a compact structure with a small footprint and convenient movement and arrangement; (2) The filling, plugging and capping, and capping of the vial are all completed on a step-by-step rail transmission mechanism, which greatly improves production efficiency; (3) The low-temperature mixing module is adopted to solve the requirement of low temperature when filling raw materials; (4) The plug clamp and the aluminum cap clamp are designed on a transfer mechanism, which effectively saves cost and space. The use of a transfer mechanism can simultaneously complete the grabbing and loading of the plug and the aluminum cap into the bottle mouth of the vial. It saves space, time and cost to a great extent, improves efficiency, and the design is simple and easy to implement; (5) A capping device with aluminum chip collection function is added, which does not affect the filling speed. While ensuring efficiency, it also ensures product quality, and the collection design is simple and easy to implement; (6) The quick-change handling claw can be customized with semicircular grooves of different diameters to achieve the filling of different specifications and models of vials. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 This is the main view of the desktop low-temperature filling, stoppering and capping machine for vials;

[0020] Figure 2This is a top view of a desktop low-temperature vial filling, stoppering and capping machine;

[0021] Figure 3 This is a structural diagram of the material sorting and feeding mechanism;

[0022] Figure 4 It is a schematic diagram of the structure of the stepping track transmission mechanism and the filling mechanism;

[0023] Figure 5 It is a top view of the stepping track transmission mechanism;

[0024] Figure 6 It is the structure of the stock liquid low temperature mixing equipment Figure 1 ;

[0025] Figure 7 It is the structure of the stock liquid low temperature mixing equipment Figure 2 ;

[0026] Figure 8 This is a schematic diagram of the roller running track of the stock liquid low-temperature mixing equipment;

[0027] Figure 9 1. It is a schematic diagram of the structure of the extrusion head assembly;

[0028] Figure 10 1. It is a schematic diagram of the plugging and capping mechanism structure;

[0029] Figure 11 This is a schematic diagram of the structure of the cover-rolling dust collection mechanism;

[0030] Figure 12 1. It is a structural diagram of a rolling cap sealing device of a rolling cap dust suction structure;

[0031] Figure 13 This is a schematic diagram of the dust collection device structure of the rolling cover dust collection structure Figure 1 ;

[0032] Figure 14 This is a schematic diagram of the dust collection device structure of the rolling cover dust collection structure Figure 2 ;

[0033] Figure 15 It is a schematic diagram of the blanking mechanism structure;

[0034] Figure 16 This is the operation flow chart of the desktop low-temperature filling, stoppering and capping machine for vials. DETAILED DESCRIPTION

[0035] See also Figure 1-2The desktop-type low-temperature filling, stoppering and capping machine for vials includes a material sorting and loading mechanism 2, a filling mechanism 4, a stepping track transmission mechanism 8, a stoppering and capping mechanism 5, a capping and dust collection mechanism 6, a material unloading mechanism 9, a waste discharge box 13, and an equipment chassis 15. The equipment chassis 15 is desktop-type, and the material sorting and loading mechanism 2, the filling mechanism 4, the stepping track transmission mechanism 8, the stoppering and capping mechanism 5, the capping and dust collection mechanism 6, the material unloading mechanism 9, and the waste discharge box 13 are all arranged above the equipment chassis 15.

[0036] See also Figure 3 The material sorting and loading mechanism 2 includes a product unpacking temporary storage platform 36 and a bottle unpacking rotary platform 38. During use, the wash-free and disinfectant-free vials are unpacked and placed upside down on the product unpacking temporary storage platform 36, with the vials facing upward. After placement, the material sorting mode is activated. The vials are evenly distributed on the platform 38 through rotation, and then transported to the stepping track conveyor mechanism 8 via the platform 38. The rotation of the bottle unpacking rotary platform 38 is controlled by a speed-regulating motor, a precision reducer, and a sensor.

[0037] See also Figure 4-5 The step-by-step track transmission mechanism 8 includes a feeding detection station 3, a finished product detection station 7, a product conveying and positioning track 42, a quick-change transport claw 43, a transport servo module 40, and an avoidance electric cylinder module 41.

[0038] The quick-change transport claw 43 is provided with multiple semicircular grooves that match the body of the vial 37; the transport servo module 40 and the avoidance electric cylinder module 41 drive the quick-change transport claw 43 to transport the vial from the material sorting and loading mechanism 2 to the product conveying positioning track 42.

[0039] The direction of transport of vials on the product conveyor track 42 is the first direction (represented by the X-axis). A direction perpendicular to and horizontal to the first direction is the second direction (from the product conveyor track 42 to the transport servo module 40 / avoidance electric cylinder module 41, represented by the Y-axis). The transport servo module 40 drives the avoidance electric cylinder module 41 back and forth in the first direction. The avoidance electric cylinder module 41 is fixedly connected to the quick-change transport finger 43 and moves back and forth in the second direction. The vials 37 are transported from the material handling mechanism 2 to the product conveyor track 42 by the quick-change transport finger 43. The specific process is as follows:

[0040] First, the material sorting and loading mechanism 2 transports the vial 37 to the semicircular groove of the quick-change transport claw 43 (the first vial station). The quick-change transport claw 43 is driven by the transport servo module 40 to move a distance in the X-axis direction ( Figure 5As shown, the moving distance is a fixed value, which is the distance between two adjacent vials), and the vial is pushed to the next station. Then, the avoidance electric cylinder module 41 drives the quick-change transport finger 43 to move a distance in the Y-axis direction (the moving distance is a fixed value, which is the radius of the vial + 5mm), so that the vial 37 is no longer in the semicircular groove of the quick-change transport finger 43. Subsequently, the quick-change transport finger 43 is driven by the transport servo module 40 to move a distance in the opposite direction of the X-axis ( Figure 5 As shown, the moving distance is a fixed value, which is the distance between two adjacent vials. Finally, the avoidance cylinder module 41 drives the quick-change transport finger 43 to move a distance in the opposite direction of the Y axis (the moving distance is a fixed value, which is the radius of the vial + 5mm). At this time, the new vial enters the semicircular groove of the quick-change transport finger 43 again. This reciprocating process completes the transfer of the vial.

[0041] The quick-change transport claw 43 is a customized mold. According to the different diameters of the vials to be filled, the quick-change transport claw 43 containing semicircular grooves of different diameters is customized to accommodate vials of different diameters. The quick-change transport claw 43 can be easily disassembled. The quick-change transport claw 43 is connected to the avoidance electric cylinder module 41 by four mounting screws 431. During installation, the working position is positioned by the positioning pins. Disassembly can be completed by simply loosening and tightening the four mounting screws 431. No subsequent adjustments are required, which is convenient and efficient. This equipment meets the filling needs of multiple specifications and models of vials by replacing the quick-change transport claw 43 and adjusting the filling program, thereby realizing the multi-purpose function of one machine, saving costs, and improving equipment utilization.

[0042] At the infeed inspection station 3, a sensor detects the presence of bottles and transmits a signal to the PLC control system. The control system then determines whether to fill the bottles. Vials that are unfilled or have a filling accuracy greater than ±5% are subsequently sent to a waste bin 13, making the filling process fully automated, simple, and efficient. At the finished product inspection station 7, the height of the bottles after filling and capping is checked to ensure they meet the required standards.

[0043] The filling mechanism 4 can be used to fill liquid or powdered materials. When filling powdered materials, the filling mechanism 4 includes a vertical follower filling head 39 and a weighing sensor. During filling, the vertical follower filling head 39 adds the powdered material to the vial. The weighing sensor is used to weigh the vial before and after filling, and the system records the weight. Vials with a filling accuracy greater than ±5% are subsequently placed in the waste bin 13.

[0044] When filling liquid materials, the filling mechanism 4 also includes a peristaltic pump 10. During filling, the speed of the peristaltic pump 10 is controlled according to the set filling volume, and the pump is started. The vertical follower filling head 39 adds the stock solution to the vial. A weighing sensor is used to weigh the vial before and after filling, and the system records the weight. Vials with a filling accuracy greater than ±5% are subsequently discharged to the waste box 13. In the present invention, a stock solution low-temperature mixing device 1 is used to mix the stock solution at low temperature before supplying it to the peristaltic pump 10.

[0045] See also Figure 6-9 The raw liquid low-temperature mixing device 1 includes a roller assembly 21, a rocking arm 75, a refrigeration plate 104, an outer frame 105, a temperature detection device (not shown), and an extrusion head assembly 108.

[0046] The refrigeration plate 104 is located in the outer frame 105. The surface temperature of the refrigeration plate 104 can be set at 2-8°C according to actual needs, and the accuracy can be controlled within ±2°C. The refrigeration plate 104 adopts a conventional refrigeration method, see Figure 7 A refrigeration pipe 112 is buried in the refrigeration plate 104 and connected to a compressor 113. A heat insulation frame 111 is arranged between the refrigeration plate 104 and the outer frame 105 to block heat transfer between the refrigeration plate 104 and the outer frame 105.

[0047] The outer frame 105 is provided with strip grooves extending vertically at both ends, through which the rocking arm 75 passes. The rocking arm 75 includes a first rocking plate 751 and a second rocking plate 752 arranged opposite each other. The roller assembly 21 includes three rollers 211 arranged in an upper, middle, and lower position, and three bearings 22 respectively passing through the three rollers. Gaskets 23 are provided on both sides of the three rollers. The ends of the bearings of the upper and lower rollers are fixedly connected to the gaskets 23. The ends of the bearing of the middle roller pass through the gaskets 23 on both sides and are respectively fixedly connected to the front ends of the first rocking plate 751 and the second rocking plate 752. One end of the bearing passing through the middle roller passes through the gasket 23 and the screw hole 753 provided at the front end of the first rocking plate 751, and the other end passes through the gasket 23 and the screw hole 753 provided at the front end of the second rocking plate 752, and is fixed with screws.

[0048] The rear ends of the first rocking plate 751 and the second rocking plate 752 are connected to the driving mechanism on the back of the outer frame 105. The driving mechanism can drive the first rocking plate 751 and the second rocking plate 752 to swing back and forth around the axis 754, thereby squeezing the liquid in the liquid storage bag 101.

[0049] During the cell preparation mixing process, the three rollers 211 significantly increase their contact area with the liquid bag 101. When the liquid volume in the liquid bag is large, they can fully squeeze the liquid to achieve uniform mixing. As the liquid in the liquid bag decreases, the servo motor controls the axis 754 of the rocker arm 75 to move away from the cooling plate 104, causing the roller assembly 21 to move closer to the cooling plate 104. This reciprocating oscillation pattern repeats to achieve uniform mixing of different volumes.

[0050] The extrusion head assembly 108 is disposed below the cooling plate 104 and includes a plurality of extrusion heads 181 that can extend and retract relative to the outer surface of the cooling plate 104. The extrusion head is made of silicone material and will not damage the liquid storage bag.

[0051] The liquid outlet pipe 107 is arranged below the liquid storage bag 101 and is connected to the peristaltic pump 10, which solves the problem of air bubbles entering the pipeline during the mixing and filling process.

[0052] The work of the stock solution low temperature mixing equipment 1 is divided into four stages:

[0053] (1) Set the temperature and install the liquid storage bag 101. Set the temperature value (e.g., 4°C) through the operation panel. The compressor 113 starts running, and the temperature detection device feeds back the temperature information of the refrigeration plate 104 to the control system in real time. After the temperature reaches the set value, initialize the mixing device on the operation panel, and the roller assembly 21 and the rocking arm 75 are away from the refrigeration plate 104, and the distance from the refrigeration plate 104 is about 80-100mm. Install the liquid storage bag 101 on the refrigeration plate 104 (e.g., hang it on the refrigeration plate with a hook). After installation, set the corresponding parameters (e.g., swing start position, swing speed, retraction distance, etc.) according to the initial volume of the liquid storage bag 101. By controlling the distance between the axis 754 of the rocking arm 75 and the refrigeration plate 104, the distance between the roller assembly 21 and the refrigeration plate 104 is adjusted so that the roller assembly 21 just contacts the lower end of the liquid storage bag 101.

[0054] (2) Initial mixing. Before filling, the servo motor drives the rocking arm 75, causing the roller assembly 21 to swing back and forth relative to the axis 754 of the rocking arm 75, gradually approaching the refrigeration plate 104, squeezing the liquid in the liquid storage bag 101. After the roller assembly 21 reaches the highest point of the motion trajectory, it quickly returns to the lower end of the liquid storage bag 101, repeating the above reciprocating swing. After mixing for 5-10 minutes, the filling is started.

[0055] (3) In the early stage of stock solution filling, the servo motor drives the rocking arm 75, which makes the roller assembly 21 swing back and forth relative to the axis 754 of the rocking arm 75, mainly relying on the roller 211 to squeeze the liquid storage bag 101. As the liquid in the liquid storage bag decreases, the servo motor controls the axis 754 of the rocking arm 75 to move away from the cooling plate 104, and then the roller 211 moves closer to the cooling plate 104, repeating the reciprocating swing trajectory to complete the mixing of different volumes.

[0056] The method of squeezing the liquid upward and mixing it by driving the roller 211 solves the problem of cell sedimentation and uneven density over time when filling the stock cell preparation. In addition, compared with mixing methods such as stirring, the shear force is small and the damage to the cells is also less.

[0057] (4) In the late stage of stock solution filling, when the distance between the roller 211 and the cooling plate 104 is about 10-20 mm, the extrusion head assembly 108 squeezes the liquid storage bag 101. The control system stops the movement of the roller 211 and the rocking arm 75. The roller 211 stops at the lower end of the liquid storage bag 101, about 10-20 mm away from the cooling plate 104, and is close to the liquid storage bag 101. During the mixing process in the late stage of filling, it plays a role in fixing the liquid storage bag 101.

[0058] The control system activates the extrusion head assembly 108, driving multiple extrusion heads 181 to alternately extend and retract, squeezing the liquid storage bag 101 in a massage-like manner, mixing the liquid within. This solves the problem of other low-temperature mixing equipment currently on the market, which struggles with mixing during the later stages of filling. Extrusion heads 181 are mushroom-shaped. The heads are made of silicone, which prevents damage to the liquid storage bag.

[0059] See also Figure 10 The plugging and capping mechanism 5 includes a rubber plug vibrating disk 11, an aluminum cover vibrating disk 12, a rubber plug and aluminum cover transplanting mechanism 70, etc. The rubber plug and the aluminum cover are placed in the rubber plug vibrating disk 11 and the aluminum cover vibrating disk 12, respectively. The motor provides power and converts it into a rotating vibration force. The vibration disk converts the input mechanical kinetic energy into the kinetic energy of the rubber plug and the aluminum cover by continuously changing the direction and amplitude of the vibration force. When the vibration disk is in a vibrating state, the rubber plug and the aluminum cover are affected by the vibration force and move up and down, left and right or in a circular direction, and are respectively transported to the rubber plug conveying trough 66 and the aluminum cover conveying trough 67 for later use.

[0060] Unlike existing designs that utilize separate stoppering and capping modules, this device integrates them. The stopper discharge port 44 and the aluminum cap discharge port 65 are integrated into a single component, effectively saving space and cost. Furthermore, the stopper gripper 45 and the aluminum cap gripper 68 are integrated into a single transfer mechanism, eliminating the need for a separate transfer mechanism and significantly reducing costs and space. This single transfer mechanism simultaneously captures and inserts both the stopper and aluminum cap into the vial's opening, significantly saving space, time, and cost, while also improving efficiency. This design is simple and easy to implement.

[0061] First, the motor controls the stopper and aluminum cap transfer mechanism 70 to move to the position just above the stopper discharge port 44 and the aluminum cap discharge port 65; then the motor controls the stopper and aluminum cap transfer mechanism 70 to move vertically downward, and the stopper clamp 45 and the aluminum cap clamp 68 are electrically controlled to open and close to respectively clamp a stopper and an aluminum cap. After clamping is completed, the motor controls the stopper and aluminum cap transfer mechanism 70 to move and transfer to the position above the stepping track conveying mechanism 8, with the stopper clamp 45 aligned to the position just above the vial that has been filled but not yet corked, and the aluminum cap clamp 68 aligned to the position just above the vial that has been corked (when corking the first vial, the control system sets only the stopper clamp 45 to operate, and the aluminum cap clamp 68 to not operate. Starting from the second vial, the stopper clamp 45 and the aluminum cap suction clamp 68 operate simultaneously. When corking the last vial, the control system sets the stopper clamp 45 to not operate, and only the aluminum cap clamp 68 to operate).

[0062] The motor controls the stopper and aluminum cap transfer mechanism 70 to move vertically downward. After the stopper contacts the vial's mouth and the aluminum cap contacts the stopper, the motor controls the jaws to open. Corresponding springs in the stopper and aluminum cap jaws 45 and 68 control the force of the upward and downward pressure on the stopper and aluminum cap, electrically controlling the stopper and aluminum cap transfer mechanism 70 to press the stopper and aluminum cap downward. After the action is completed, the motor controls the stopper and aluminum cap transfer mechanism 70 to move to its initial position.

[0063] See also Figure 11-14 The capping dust collection mechanism 6 includes a servo lift module 46, a guide fixing structure 50, a capping cutter head 57, a dust collection device 17, and a capping sealing device. The capping sealing device includes a stainless steel capping cover 63 and a transition joint 64. The dust collection device 17 includes a pipeline 53, a dust collection device outer cover 60, a dust collection device upper cover 62, a dust collection fan 61, and a filter element 55.

[0064] The stainless steel capping cover 63 and the transition joint 64 are fixedly connected by threads to form a cavity for accommodating the cap part of the vial. The capping cutter head 57 is located inside the cavity. The stainless steel capping cover 63 and the capping cutter head 57 can move up and down synchronously. The transition joint 64 is provided with an interface connected to the dust suction device 17, thereby connecting the dust suction device 17 with the cavity.

[0065] During use, the vial 37, after being stoppered and capped, is conveyed by the step-by-step conveyor mechanism 8 to the capping station, where the control system initiates the capping process. The stainless steel capping cover 63 and transition joint 64 wrap around the capping blade 57 and simultaneously move downward. The vial 37 passes through the circular hole at the lower end of the stainless steel capping cover 63, and the cap portion of the vial enters the capping and sealing device. The capping blade 57 performs the capping operation. Aluminum shavings generated during the process are collected by the dust collection fan 61 along the pipeline 53 and into the filter element 55. After capping is completed, the stainless steel capping cover 63 and transition joint 64 wrap around the capping blade 57 and simultaneously move upward, and the cap portion of the vial exits the capping and sealing device. The step-by-step conveyor mechanism 8 pushes the capped vial 37 to the next station. The vials complete the capping process sequentially via the step-by-step track conveyor mechanism 8. Because the capping process collects aluminum chips, it eliminates the problem of aluminum chips contaminating the product and the environment. Consequently, vials 37 are transported on the step-by-step track conveyor mechanism 8, completing the filling, stoppering, capping, and capping processes sequentially. This allows operations to be completed on a single production line, saving space and time. Furthermore, the control system adjusts the height of the capping cutter head 57 based on the height of the vials, enabling the capping process to accommodate vials of varying sizes.

[0066] Currently, there is no capping equipment on the market with an aluminum chip collection function, which will cause pollution to the product and the environment during the capping process. This equipment has added an aluminum chip collection function. First, during the capping process, a sealed environment is created for the cap and the body of the vial through the stainless steel capping cover 63 and the transition joint 64, and the aluminum chips generated during the capping process are collected into the filter element 55 by the dust suction fan 61. The lifting and lowering of the stainless steel capping cover 63 and the transition joint 64 are synchronized with the lifting and lowering of the capping cutter head 57. Second, to avoid the backflow of particulate matter, the pipeline 53 is curved. Third, the filter element 55 is a consumable product with functions such as easy replacement and convenient disassembly. The capping equipment with an aluminum chip collection function does not affect the filling speed. While ensuring efficiency, it also ensures product quality, and the collection design method is simple and easy to implement.

[0067] See also Figure 15 The unloading mechanism 9 includes a waste discharge cylinder 58, a finished product detection sensor 59, a waste discharge box 13 and a material receiving tray 71.

[0068] During use, the capped vials are transferred to the finished product inspection station 7. The finished product inspection sensor 59 detects the height of the vials and transmits the test results to the control system. If the bottle height is not within the range set by the system, the system will identify it as an unqualified product, and the unqualified products will be sent to the waste box 13. Qualified products are sent to the discharge track and placed on the receiving tray 71. The system's counting function determines whether the receiving tray 71 is full. If it is full, a shutdown alarm will notify personnel to remove the tray and replace it with a new one. This equipment removes products that fail to meet the filling volume requirements, plugging and capping requirements, and capping requirements before unloading, saving the cost and time of subsequent manual removal.

[0069] See also Figure 16 , is the operating flow chart of the desktop low-temperature filling, stoppering and capping integrated machine for penicillin bottles of the present invention. The bottle sorting rotary table 38 sends the penicillin bottle 37 to the feeding inspection station 3. First, the feeding inspection station 3 detects whether the penicillin bottle 37 is correctly placed in the designated position. The signal is transmitted to the PLC control system, and the transport servo module 40 and the avoidance electric cylinder module 41 work together to move the penicillin bottle 37 to the next station. When the penicillin bottle 37 is moved to the filling station, according to the detection result of the feeding inspection station 3, the control system issues instructions to the upper and lower follow-up filling heads 39 and the peristaltic pump 10 on whether to fill it. During filling, according to the set filling volume, the control system automatically switches to the corresponding speed of the peristaltic pump 10, starts running, and the upper and lower follow-up filling heads 39 complete the filling. The weighing sensor will record the weight of the penicillin bottle before and after filling. If the weight exceeds the set accuracy, the system will determine it as an unqualified product, and the penicillin bottle will eventually enter the waste box 13. The vial 37 is moved to the next station by the coordinated action of the transport servo module 40 and the avoidance cylinder module 41 for subsequent stoppering, capping, and capping. Finally, it is inspected at the finished product inspection station 7. Qualified products are discharged, while unqualified products are sent to the waste bin 13.

[0070] The desktop low-temperature vial filling, stoppering, and capping machine of the present invention is compact, requires minimal space, and is easy to transport and debug. By replacing the relevant mold components, it can fill vials of varying specifications and models. It is simple to operate, achieving multi-purpose functionality and significantly improving equipment utilization.

[0071] The low-temperature mixing module equipped with the equipment meets the needs of reagents that need to be filled under low-temperature conditions. While maintaining low temperatures, cells and other preparations can be fully mixed, and at the same time, the shear force is small, which does not damage the cells. The filling module adjusts the filling program by replacing the quick-change handling claws to meet the filling needs of multiple specifications and models of vials. The filling process is automated, simple and efficient; the stoppering and capping module is designed to combine the stopper discharge port and the aluminum cap discharge port on a single workpiece, and a transfer mechanism can be used to complete the grabbing and loading of the stopper and aluminum cap (vial mouth). This saves space, time and cost, and improves efficiency. The capping module is designed with an aluminum chip collection function, which can effectively collect aluminum chips during the process to avoid pollution of the product and the environment.

[0072] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit the same. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the various embodiments of the present invention.

Claims

1. A desktop low-temperature filling, stoppering and capping machine for vials, comprising a material handling and loading mechanism (2), a filling mechanism (4), a stepping track transmission mechanism (8), a stoppering and capping mechanism (5), a capping and dust collecting mechanism (6), a material unloading mechanism (9), a waste discharge box (13), and an equipment chassis (15); characterized in that: The equipment chassis (15) is desktop-type, and the material handling and loading mechanism (2), the filling mechanism (4), the stepping track transmission mechanism (8), the plugging and capping mechanism (5), the capping and dust collection mechanism (6), the unloading mechanism (9), and the waste discharge box (13) are all arranged above the equipment chassis (15); The material sorting and loading mechanism (2) is used to adjust the position of the vials (37) and transmit them to the stepping track transmission mechanism (8); the filling mechanism (4) is used to fill the vials (37) on the stepping track transmission mechanism (8) with raw materials; the plugging and capping mechanism (5) is used to add rubber plugs and aluminum caps to the vials; the capping and dust collection mechanism (6) is used to cap the vials (37) and absorb aluminum chips generated during the capping process; the unloading mechanism (9) is used to screen and collect the vials (37) that have passed the filling process, and the waste box (13) is used to collect the vials (37) that have failed the filling process; The capping dust suction mechanism (6) comprises a capping cutter head (57), a dust suction device (17), and a capping sealing device. The capping sealing device comprises a stainless steel capping cover (63) and a transition joint (64). The dust suction device (17) comprises a dust suction device outer cover (60), a dust suction device upper cover (62), a dust suction fan (61), and a filter element (55). The stainless steel capping cover (63) and the transition joint (64) are fixedly connected by threads to form a cavity for accommodating the cap portion of the vial. The capping cutter head (57) is located inside the cavity. The stainless steel capping cover (63) and the capping cutter head (57) can move up and down synchronously. The transition joint (64) is provided with an interface connected to the dust suction device (17), thereby connecting the dust suction device (17) with the cavity. The stoppering and capping mechanism (5) comprises a rubber stopper vibrating plate (11), an aluminum cap vibrating plate (12), and a rubber stopper and aluminum cap transplanting mechanism (70). The rubber stopper vibrating plate (11) is provided with a rubber stopper conveying trough (66) and a rubber stopper discharge port (44). The aluminum cap vibrating plate (12) is provided with an aluminum cap conveying trough (67) and an aluminum cap discharge port (65). The rubber stopper and aluminum cap transplanting mechanism (70) is provided with a rubber stopper clamping claw (45) and an aluminum cap clamping claw (68). The transplanting mechanism simultaneously completes the grabbing and loading of the rubber stopper and the aluminum cap into the bottle mouth of the vial. The integrated machine further comprises a stock solution low-temperature mixing device (1), which is used to mix and control the temperature of the stock solution to be filled; The raw liquid low-temperature mixing device (1) includes a refrigeration plate (104), an outer frame (105), and a reciprocating extrusion device. The reciprocating extrusion device includes: a roller assembly (21), a rocking arm (75), the rocking arm (75) including a first rocking plate (751) and a second rocking plate (752) arranged opposite to each other, the roller assembly (21) including three rollers (211) arranged in the upper, middle and lower parts, and three bearings (22) respectively passing through the three rollers, gaskets (23) are provided on both sides of the three rollers, and the upper rollers are provided with a gasket (23). The two ends of the bearings of the roller and the lower roller are fixedly connected to the gasket (23), and the two ends of the bearing of the middle roller pass through the gaskets (23) on both sides and are fixedly connected to the front ends of the first rocking plate (751) and the second rocking plate (752) respectively; the rear ends of the first rocking plate (751) and the second rocking plate (752) are connected to the driving mechanism on the back side of the outer frame (105), and the driving mechanism can drive the first rocking plate (751) and the second rocking plate (752) to swing back and forth around the axis (754).

2. The all-in-one machine according to claim 1, characterized in that: The step-by-step track transmission mechanism (8) includes a product conveying and positioning track (42), a quick-change transport claw (43), a transport servo module (40), and an avoidance electric cylinder module (41); The transport servo module (40) drives the avoidance electric cylinder module (41) to move back and forth in a first direction, and the avoidance electric cylinder module (41) is fixedly connected to the quick-change transport claw (43) to drive the quick-change transport claw (43) to move back and forth in a second direction; The quick-change transport claw (43) is provided with a plurality of semicircular grooves matching the body of the vial, and the vial (37) is transported from the material sorting and loading mechanism to the product conveying and positioning track (42) by the quick-change transport claw (43); The first direction is the transport direction of the vial (37) on the product transport positioning track (42); the second direction is perpendicular to the first direction and parallel to the plane of the product transport positioning track (42).

3. The all-in-one machine according to claim 1, characterized in that: The rubber plug discharge port (44) and the aluminum cover discharge port (65) are on one processed part.

4. The all-in-one machine according to claim 1, characterized in that: The stainless steel capping cover (63) is fixed on the capping lifting shaft. When the capping lifting shaft descends, the stainless steel capping cover (63) and the transition joint (64) wrap the capping cutter head (57) and move downward at the same time, and the cap of the vial enters the cavity. When the capping lifting shaft rises, the cap of the vial exits the cavity.

5. The all-in-one machine according to claim 4, characterized in that: When the capping cutter head (57) is in operation, the dust collecting device (17) is turned on to suck aluminum scraps generated by capping into the filter element (55) through the pipeline (53).

6. The all-in-one machine according to any one of claims 1 to 5, characterized in that: The raw liquid low-temperature mixing device (1) further includes an extrusion head assembly (108), wherein the extrusion head assembly (108) is arranged at the lower part of the refrigeration plate (104), and the extrusion head assembly (108) includes a plurality of extrusion heads (181), and the plurality of extrusion heads (181) can extend and retract relative to the outer surface of the refrigeration plate (104).

7. The all-in-one machine according to claim 6, characterized in that: The filling mechanism (4) includes a peristaltic pump (10), an upper and lower follower filling head (39), and a weighing sensor. The peristaltic pump (10) is connected to the stock solution low-temperature mixing device (1) and is used to transmit the stock solution to the upper and lower follower filling head (39). The upper and lower follower filling head (39) is used to fill the stock solution into the vial (37). The weighing sensor is used to weigh the vial before and after filling.

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