Sodium dichloroisocyanurate foaming disinfection powder as well as preparation method and application thereof

Abstract

The invention provides sodium dichloroisocyanurate foaming disinfection powder as well as a preparation method and application thereof, and belongs to the technical field of disinfectants. The disinfectant provided by the invention comprises the following raw materials in parts by mass: 30-40 parts of sodium dichloroisocyanurate, 1-5 parts of a pH regulator, 5-20 parts of anhydrous sodium sulfate, 5-20 parts of an emulsifier, 10-40 parts of a foaming agent, 0.1-1 part of a carbon quantum dot corrosion inhibitor, 1-5 parts of a stabilizer, 0.1-2 parts of a chelating agent and 1-5 parts of an antifreeze agent. The sodium dichloroisocyanurate foaming disinfection powder provided by the invention has a cleaning function, and is excellent in sterilization and disinfection effect, convenient to use and small in side effect and corrosion.

Description

Technical Field

[0001] The present invention belongs to the technical field of disinfectants, and particularly relates to a sodium dichloroisocyanurate foaming disinfectant powder, a preparation method thereof and an application thereof. Background Art

[0002] There are various disinfectants on the market, which can be divided into chlorine-containing disinfectants, peroxide disinfectants, aldehyde disinfectants, alcohol disinfectants, iodine-containing disinfectants, phenolic disinfectants, ethylene oxide, biguanide disinfectants and quaternary ammonium salt disinfectants. Among them, chlorine-containing disinfectants can kill various microorganisms, including bacterial propagules, viruses, fungi, mycobacterium tuberculosis and bacterial spores with relatively strong resistance.

[0003] At present, chlorine-containing disinfectants have a single function and can only be used for sterilization and disinfection, without the function of decontamination and cleaning; moreover, they are unstable in nature and are easily affected by light, heat and humidity, losing their active ingredients. Therefore, there is an urgent need for an excellent disinfectant with a cleaning function, excellent sterilization and disinfection effects, convenient use, low side effects and low corrosiveness to meet the modern people's demand for disinfection. Summary of the Invention

[0004] In view of this, the purpose of the present invention is to provide a sodium dichloroisocyanurate foaming disinfectant powder, a preparation method thereof and an application thereof. The present invention provides a broad-spectrum disinfection product with high efficiency, stability, corrosion inhibition and decontamination ability, meeting the strong demand of the market.

[0005] In order to achieve the above-mentioned invention purpose, the present invention provides the following technical solutions:

[0006] The present invention provides a sodium dichloroisocyanurate foaming disinfectant powder, which comprises the following raw materials in parts by mass: 30-40 parts of sodium dichloroisocyanurate, 1-5 parts of a pH regulator, 5-20 parts of anhydrous sodium sulfate, 5-20 parts of an emulsifier, 10-40 parts of a foaming agent, 0.1-1 part of a carbon quantum dot corrosion inhibitor, 1-5 parts of a stabilizer, 0.1-2 parts of a chelating agent, and 1-5 parts of an antifreeze.

[0007] The present invention provides a sodium dichloroisocyanurate foaming disinfectant powder, which comprises the following raw materials in parts by mass: 35 parts of sodium dichloroisocyanurate, 1 part of a pH regulator, 10 parts of anhydrous sodium sulfate, 18.6 parts of an emulsifier, 30 parts of a foaming agent, 0.2 part of a carbon quantum dot corrosion inhibitor, 0.2 part of a chelating agent, and 5 parts of an antifreeze.

[0008] The present invention provides a sodium dichloroisocyanurate foaming disinfectant powder, which comprises the following raw materials in parts by mass: 35 parts of sodium dichloroisocyanurate, 1 part of a pH regulator, 5 parts of anhydrous sodium sulfate, 18.5 parts of an emulsifier, 35 parts of a foaming agent, 0.2 part of a carbon quantum dot corrosion inhibitor, 0.3 part of a chelating agent, and 6 parts of an antifreeze.

[0009] The present invention provides a sodium dichloroisocyanurate foaming disinfectant powder, which comprises the following raw materials in parts by mass: 36 parts of sodium dichloroisocyanurate, 1 part of pH regulator, 6 parts of anhydrous sodium sulfate, 20 parts of emulsifier, 31.5 parts of foaming agent, 0.2 part of carbon quantum dot corrosion inhibitor, 0.3 part of chelating agent, and 5 parts of antifreeze.

[0010] Preferably, the emulsifier comprises at least one of fatty alcohol polyoxyethylene ether and modified silicone resin polyoxyethylene ether.

[0011] Preferably, the foaming agent comprises at least one of sodium dodecyl sulfate, sodium dodecylbenzenesulfonate, and secondary alkylbenzenesulfonate.

[0012] Preferably, the chelating agent comprises at least one of sodium tripolyphosphate, sodium hexametaphosphate, and trisodium phosphate.

[0013] Preferably, the antifreeze comprises at least one of calcium chloride, magnesium chloride, and sodium chloride.

[0014] The present invention also provides a preparation method of the above-mentioned sodium dichloroisocyanurate foaming disinfectant powder, which comprises the following steps:

[0015] 1) Dry and then crush and mix sodium dichloroisocyanurate, sodium bicarbonate, anhydrous sodium sulfate, antifreeze, and chelating agent to obtain a first mixed powder.

[0016] 2) Mix the first mixed powder obtained in step 1) with an emulsifier, a foaming agent, and a carbon quantum dot corrosion inhibitor to obtain the sodium dichloroisocyanurate foaming disinfectant powder.

[0017] The present invention also provides a usage method of the above-mentioned sodium dichloroisocyanurate foaming disinfectant powder, which includes: diluting the sodium dichloroisocyanurate foaming disinfectant powder with water by 100-1000 times to obtain a sodium dichloroisocyanurate foaming washing and disinfecting aqueous solution.

[0018] The beneficial technical effects of the present invention are as follows:

[0019] 1. By optimizing the raw material composition ratio of the sodium dichloroisocyanurate foaming disinfectant powder, the present invention improves the disinfection effect of the sodium dichloroisocyanurate foaming disinfectant powder and realizes its washing and cleaning function.

[0020] 2. The present invention adds a foaming agent and an emulsifier. Adding an emulsifier can improve the stability of the prepared sodium dichloroisocyanurate foaming disinfectant powder, extend the action period, and maintain its effectiveness; adding a foaming agent plays a role in foaming and wall hanging, and decontamination and cleaning.

[0021] 3. Through the synergistic effect of each component, the present invention can improve the bactericidal effect and stability of the sodium dichloroisocyanurate foaming powder, and at the same time has the advantages of decontamination and cleaning, easy transportation and storage.

[0022] 4. The compound disinfectant adds a foaming disinfection method. After the disinfectant is dissolved in water, it is used in conjunction with a foaming gun to produce delicate and visible foam, which increases the time of attachment to the surface of the disinfection object. When disinfecting instruments and farm cages, the surface residence time is longer, making the disinfection more thorough. Compared with low-foam disinfectant solutions of the same concentration, the disinfection effect is better.

[0023] 5. Carbon quantum dot corrosion inhibitor can effectively resist the corrosion of various metals by the disinfectant. Sodium dodecyl sulfate not only has a foaming function but also can reduce the corrosiveness of sodium dichloroisocyanurate to metals. Sodium dodecyl sulfate can be adsorbed on the metal surface and compete with chloride ions in the solution for adsorption, weakening the destructive effect of chloride ions. The carbon quantum dot corrosion inhibitor and sodium dodecyl sulfate interact with each other and can jointly cover the metal surface to form a protective film to resist the corrosion of strongly oxidizing, acidic, and high-concentration anion solutions. Detailed implementation mode

[0024] The present invention provides a sodium dichloroisocyanurate foaming disinfection powder, which comprises the following raw materials in parts by mass: 30-40 parts of sodium dichloroisocyanurate, 1-5 parts of pH regulator, 5-20 parts of anhydrous sodium sulfate, 5-20 parts of emulsifier, 10-40 parts of foaming agent, 0.1-1 part of carbon quantum dot corrosion inhibitor, 1-5 parts of stabilizer, 0.1-2 parts of chelating agent, and 1-5 parts of antifreeze.

[0025] The present invention has no special limitation on the source of the raw materials, and conventional commercially available products in the art can be used.

[0026] In the present invention, the emulsifier preferably includes at least one of fatty alcohol polyoxyethylene ether and modified silicone resin polyoxyethylene ether.

[0027] In the present invention, the foaming agent preferably includes at least one of sodium dodecyl sulfate, sodium dodecylbenzenesulfonate, and secondary alkylbenzenesulfonate.

[0028] In the present invention, the chelating agent preferably includes at least one of sodium tripolyphosphate, sodium hexametaphosphate, and trisodium phosphate.

[0029] In the present invention, the antifreeze preferably includes at least one of calcium chloride, magnesium chloride, and sodium chloride.

[0030] In the present invention, the carbon quantum dot corrosion inhibitor is synthesized from glucose and thiourea as raw materials. The preparation method of the carbon quantum dot corrosion inhibitor is as follows: Take glucose and thiourea in a mass ratio of (2:1), then dissolve them in distilled water and stir to form a clear aqueous solution. The obtained solution is ultrasonicated for 30 - 60 minutes and then placed in a microwave oven and heated for 10 - 30 minutes. After the brown solid is cooled to room temperature, it is dissolved in distilled water to form a dark brown solution. In a centrifuge, it is centrifuged for 10 - 30 minutes to remove particulate precipitation, and the supernatant is taken. The supernatant is subjected to vacuum drying and separation to obtain a filtrate and a filter residue. The filtrate is vacuum dried at 70 °C for 10 - 20 hours to obtain the carbon quantum dot corrosion inhibitor.

[0031] The present invention also provides a preparation method of the above-mentioned sodium dichloroisocyanurate foaming disinfectant powder, which includes the following steps:

[0032] 1) After drying sodium dichloroisocyanurate, sodium bicarbonate, anhydrous sodium sulfate, antifreeze and chelating agent, they are pulverized and mixed to obtain a first mixed powder;

[0033] 2) Mix the first mixed powder obtained in step 1) with an emulsifier, a foaming agent and a carbon quantum dot corrosion inhibitor to obtain the sodium dichloroisocyanurate foaming disinfectant powder.

[0034] The present invention has no special limitation on the drying method, and preferably uses oven drying. The drying temperature is preferably 50 °C to 120 °C, and the drying time is preferably 25 - 35 min.

[0035] The technical solutions provided by the present invention are described in detail below in conjunction with embodiments, but they cannot be understood as limiting the protection scope of the present invention.

[0036] Example 1

[0037] The preparation method of the sodium dichloroisocyanurate foaming disinfectant powder has the following steps:

[0038] Step 1: Put 35% of sodium dichloroisocyanurate, 1% of sodium bicarbonate, 10% of anhydrous sodium sulfate, 5% of sodium chloride and 0.2% of trisodium phosphate into an oven and dry them at 50 °C to 120 °C for 30 min;

[0039] Step 2: Pulverize and sieve the dried sodium dichloroisocyanurate, sodium bicarbonate, anhydrous sodium sulfate, sodium chloride and trisodium phosphate, and mix and stir them evenly;

[0040] Step 3: Add 18.6% of modified silicone resin polyoxyethylene ether, 30% of sodium dodecyl sulfate and 0.2% of carbon quantum dot corrosion inhibitor to the mixed powder and mix them evenly to obtain the sodium dichloroisocyanurate foaming disinfectant powder.

[0041] The dilution ratio of the prepared sodium dichloroisocyanurate foaming disinfectant powder is 1:100 to 1000 to obtain an aqueous solution of sodium dichloroisocyanurate for foaming, washing and disinfection.

[0042] Example 2

[0043] The preparation method of sodium dichloroisocyanurate foaming disinfectant powder, the steps are as follows;

[0044] Step 1: Put 35% of sodium dichloroisocyanurate, 1% of sodium bicarbonate, 5% of anhydrous sodium sulfate, 6% of magnesium chloride and 0.3% of trisodium phosphate into the oven respectively, and dry at 50°C to 120°C for 30 minutes;

[0045] Step 2: Crush and sieve the dried sodium dichloroisocyanurate, sodium bicarbonate, anhydrous sodium sulfate, magnesium chloride and trisodium phosphate, and mix and stir evenly;

[0046] Step 3: Add 18.5% of modified silicone polyoxyethylene ether, 35% of sodium dodecyl sulfate and 0.2% of carbon quantum dot corrosion inhibitor to the mixed powder, and mix evenly to obtain sodium dichloroisocyanurate foaming disinfectant powder.

[0047] The dilution ratio of the prepared sodium dichloroisocyanurate foaming disinfectant powder is 1:100 to 1000 to obtain an aqueous solution of sodium dichloroisocyanurate for foaming, washing and disinfection.

[0048] Example 3

[0049] The preparation method of sodium dichloroisocyanurate foaming disinfectant powder, the steps are as follows;

[0050] Step 1: Put 36% of sodium dichloroisocyanurate, 1% of sodium bicarbonate, 6% of anhydrous sodium sulfate, 5% of magnesium chloride and 0.3% of sodium tripolyphosphate into the oven respectively, and dry at 50°C to 120°C for 30 minutes;

[0051] Step 2: Crush and sieve the dried sodium dichloroisocyanurate, sodium bicarbonate, anhydrous sodium sulfate, magnesium chloride and sodium tripolyphosphate, and mix and stir evenly;

[0052] Step 3: Add 20% of emulsifier, 31.5% of foaming agent and 0.2% of carbon quantum dot corrosion inhibitor to the mixed powder, and mix evenly to obtain sodium dichloroisocyanurate foaming disinfectant powder.

[0053] The dilution ratio of the prepared sodium dichloroisocyanurate foaming disinfectant powder is 1:100 to 1000 to obtain an aqueous solution of sodium dichloroisocyanurate for foaming, washing and disinfection.

[0054] Example 4

[0055] 1. Microbial killing test

[0056] Inspection basis: "Disinfection Technical Specification" (2002 edition).

[0057] Experimental strains: Escherichia coli (8099), Staphylococcus aureus (ATCC6538), Candida albicans (ATCC10231).

[0058] Test temperature: 20°C.

[0059] Disinfectant concentration: 0.02% aqueous solution.

[0060] Sterilization time: 5 min for Escherichia coli (8099), Staphylococcus aureus (ATCC6538), and Candida albicans (ATCC10231).

[0061] Under the experimental conditions, the disinfectants of Examples 1-3 acted on Escherichia coli (8099), Staphylococcus aureus (ATCC6538), and Candida albicans (ATCC10231) for 5 min respectively, and all achieved the effect of complete killing. The experimental results are shown in Table 1.

[0062] Table 1 Killing logarithm

[0063]

[0064] 2. Acute oral toxicity test

[0065] Inspection basis: "Disinfection Technical Specification" (2002 edition).

[0066] Sample preparation: Weigh 10.0 g of the sample, prepare 1000 ml with distilled water, and mix well.

[0067] Experimental observation: Observe and record the poisoning manifestations of each group of animals and the number of dead animals every day, and conduct gross pathological examinations on the dead animals during the test and the surviving animals at the end of the test. The 14-day test is over.

[0068] The experimental results show that no abnormalities occurred in the mice during the 14-day observation after feeding the disinfectants of Examples 1-3 to the mice, no deaths occurred in the mice, and the mice were sacrificed for dissection at 14 d, and no abnormalities were found in the gross pathological examination. The experimental results are shown in Table 2.

[0069] Table 2 Acute oral toxicity test

[0070]

[0071] The experimental results show that the acute oral toxicity of the disinfectant of the present invention in mice is LD 50 > 5000 mg / kg·bw. According to the acute toxicity classification standard, the sodium dichloroisocyanurate foaming disinfectant powder provided by the present invention belongs to the actually non-toxic level.

[0072] 3. Disinfectant powder stability test

[0073] To evaluate the stability of the active ingredient content of the present invention, the samples were stored in a sealed container at 37 °C for a stability test. The results of regular sampling are shown in Table 3:

[0074] Table 3 Stability test (oxidation ability expressed as the percentage of available chlorine over time (days))

[0075]

[0076] The change in available chlorine content was within the expected experimental range, indicating good stability in the short term.

[0077] 4. Foaming and decontamination test of disinfection powder

[0078] 40 g of the finished sodium dichloroisocyanurate foaming disinfection powder was added to 20 L of water and diluted. After stirring evenly, foam was ejected from a foaming gun onto the glass surface (tilt angle < 15°) to observe the foam and its retention. The test was repeated 5 - 10 times. The test results are shown in Table 4.

[0079] Table 4 Foaming and wall - hanging decontamination test

[0080]

[0081] Disinfection effect:

[0082] According to the quantitative sterilization specification in the "Inspection Method for Bactericidal Effect of Disinfectants in Laboratory", the bactericidal experiment of sodium dichloroisocyanurate foaming disinfection powder on Gram - positive bacteria and Gram - negative bacteria was carried out. The method steps of the bactericidal experiment are as follows:

[0083] (1) The prepared bacterial solution was subjected to viable count, and then diluted with 0.03 mo1 / L phosphate buffer to an experimental bacterial solution containing 10 6 - 10 7 CFU / ml;

[0084] (2) The sample was diluted with sterile water into disinfectant solutions of different test concentrations, and 4.5 mL was taken into a test tube;

[0085] (3) 0.5 ml of the experimental bacterial solution was pipetted into 4.5 m test - concentration disinfectant solution;

[0086] (4) The disinfectant and the bacterial solution were allowed to react fully for 10 min;

[0087] (5) Immediately, 0.5 m of the above - mentioned bacterial - drug mixture was pipetted and added to 4.5 mL of neutralizing solution and mixed evenly;

[0088] (6) After neutralization for 10 minutes, plate spreading and viable count were carried out to calculate the sterilization rate;

[0089] (7) Calculation of bactericidal rate: According to the results of viable bacteria counting, calculate the bactericidal rate (Pt); the bactericidal rate (Pt) at time t of disinfection = [(n 0 - n) / n,] x 100%, where n 0 is the number of viable bacteria before disinfection or in the control group, and n is the number of viable bacteria after disinfection or in the test group. The killing results of Gram-positive bacteria and Gram-negative bacteria are shown in Table 5.

[0090] Table 5 Bactericidal test of foaming bactericide against Gram bacteria

[0091]

[0092] The above are only the preferred embodiments of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the principle of the present invention, several improvements and refinements can be made, and these improvements and refinements should also be regarded as the protection scope of the present invention.

Claims

1. A sodium dichloroisocyanurate foaming disinfectant powder, characterized in that: The invention comprises the following raw materials in parts by weight: 30-40 parts of sodium dichloroisocyanurate, 1-5 parts of pH adjuster, 5-20 parts of anhydrous sodium sulfate, 5-20 parts of emulsifier, 10-40 parts of foaming agent, 0.1-1 parts of carbon quantum dot corrosion inhibitor, 1-5 parts of stabilizer, 0.1-2 parts of chelating agent and 1-5 parts of antifreeze agent.

2. A sodium dichloroisocyanurate foaming disinfectant powder, characterized in that: The invention comprises the following raw materials in parts by weight: 35 parts of sodium dichloroisocyanurate, 1 part of pH regulator, 10 parts of anhydrous sodium sulfate, 18.6 parts of emulsifier, 30 parts of foaming agent, 0.2 parts of carbon quantum dot corrosion inhibitor, 0.2 parts of chelating agent and 5 parts of antifreeze agent.

3. A sodium dichloroisocyanurate foaming disinfectant powder, characterized in that: The invention comprises the following raw materials in parts by weight: 35 parts of sodium dichloroisocyanurate, 1 part of pH adjuster, 5 parts of anhydrous sodium sulfate, 18.5 parts of emulsifier, 35 parts of foaming agent, 0.2 parts of carbon quantum dot corrosion inhibitor, 0.3 parts of chelating agent and 6 parts of antifreeze agent.

4. A sodium dichloroisocyanurate foaming disinfectant powder, characterized in that: The invention comprises the following raw materials in parts by weight: 36 parts of sodium dichloroisocyanurate, 1 part of pH regulator, 6 parts of anhydrous sodium sulfate, 20 parts of emulsifier, 31.5 parts of foaming agent, 0.2 parts of carbon quantum dot corrosion inhibitor, 0.3 parts of chelating agent and 5 parts of antifreeze agent.

5. A sodium dichloroisocyanurate foaming disinfectant powder according to claim 1, characterized in that: The emulsifier includes at least one of fatty alcohol polyoxyethylene ether and modified silicone resin polyoxyethylene ether.

6. A sodium dichloroisocyanurate foaming disinfectant powder according to claim 1, characterized in that: The foaming agent includes at least one of sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, and sodium secondary alkylbenzene sulfonate.

7. A sodium dichloroisocyanurate foaming disinfectant powder according to claim 1, characterized in that: The chelating agent includes at least one of sodium tripolyphosphate, sodium hexametaphosphate and trisodium phosphate.

8. A sodium dichloroisocyanurate foaming disinfectant powder according to claim 1, characterized in that: The antifreeze agent includes at least one of calcium chloride, magnesium chloride and sodium chloride.

9. The method for preparing a sodium dichloroisocyanurate foaming disinfectant powder according to any one of claims 1 to 8, characterized in that: The following steps are involved: 1) drying sodium dichloroisocyanurate, sodium bicarbonate, anhydrous sodium sulfate, an antifreeze agent and a chelating agent, and then crushing and mixing them to obtain a first mixed powder; 2) The first mixed powder obtained in step 1) is mixed with an emulsifier, a foaming agent and a carbon quantum dot corrosion inhibitor to obtain sodium dichloroisocyanurate foaming disinfectant powder.

10. The method for using the sodium dichloroisocyanurate foaming disinfectant powder according to any one of claims 1 to 8 comprises: The sodium dichloroisocyanurate foaming disinfectant powder is diluted 100 to 1000 times with water to obtain a sodium dichloroisocyanurate foaming washing and disinfecting aqueous solution.

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