Double-frequency ultrasonic foot tub for traditional Chinese medicine health care

Abstract

A double-frequency ultrasonic foot tub for traditional Chinese medicine health care is characterized by comprising a base, a control circuit, a foot massage basin, a heating constant temperature device, a control panel and a double-frequency ultrasonic element. Wherein the multiple double-frequency ultrasonic elements (ultrasonic vibrators) are arranged at the bottom of the foot tub in one group and correspond to the positions of acupuncture points of the foot soles, and eight double-frequency ultrasonic elements are arranged on each of the left foot and the right foot; and the other group is electrically connected with the ultrasonic generator after being connected in parallel. Other optional elements comprise a filtering device and a sterilizing device. The double-frequency ultrasonic foot bath tub for traditional Chinese medicine health care is used for Chinese herbal medicine foot bath health care, during foot bath, Chinese herbal medicine foot bath liquid is added, the heating water temperature of the heater is adjusted, both feet are put into the foot massage barrel, and different operation modes of a double-frequency ultrasonic system are started, so that the double-frequency ultrasonic foot bath tub has remarkable acupuncture point stimulation and ultrasonic permeation promotion effects, and transdermal absorption of active ingredients in the foot bath liquid can be improved; good treatment and health-care effects are achieved on various diseases such as hyperuricemia, hypertension and insomnia.

Description

Technical Field

[0001] The present invention relates to a healthcare technology, in particular to a traditional Chinese medicine healthcare technology, and specifically to a dual-frequency ultrasonic foot bath basin for traditional Chinese medicine health preservation and nourishment. Background Art

[0002] With the increasing number of drug side effects and the continuous emergence of drug-induced diseases, and sometimes the unpleasant taste and smell causing patients to become non-compliant, more and more people advocate natural healthcare methods. Traditional Chinese medicine foot bath is a healthcare method of soaking feet with the juice decocted from traditional Chinese medicine, which is a non-invasive natural therapy integrating treatment and healthcare based on traditional Chinese medicine principles. During the soaking process, with the help of the medicinal power and the heat of water, the active ingredients of traditional Chinese medicine are absorbed transdermally through the skin pores and transmitted through the meridians, enabling the qi and blood of the body to circulate smoothly. After the blood vessels are unobstructed, the medicine travels with the heat and is absorbed while it is hot, and the meridians circulate to reach the affected area directly. Because of its simple treatment method, small side effects, and good clinical effects, it is widely used in clinical practice. Numerous clinical experiments have shown that foot therapy has a wide range of applications, and different foot baths with traditional Chinese medicine decoctions have a wide range of indications: such as dizziness, headache, insomnia, neurasthenia; chronic pharyngitis, rhinitis, cold, cough, bronchial asthma; thromboangiitis obliterans of the lower extremities, paronychia, eczema tinea pedis, toe deformity, varicose veins of the lower extremities; rheumatic joint pain, heel pain, low back pain and sciatica; cardiovascular diseases such as hypertension, coronary heart disease, sequelae of stroke, obesity; gastrointestinal diseases such as gastroptosis, constipation; diabetes, brain atrophy, Alzheimer's disease, and gynecological diseases such as dysmenorrhea, irregular menstruation, etc.

[0003] The transdermal absorption of active ingredients of traditional Chinese medicine is an important mechanism for the action of traditional Chinese medicine foot bath. This drug absorption method of directly penetrating the skin and entering the blood and then circulating throughout the body can also avoid the liver toxicity of some drugs and the destruction of some effective ingredients of drugs by the gastrointestinal tract, so it shows better treatment effects for some diseases than oral drugs in clinical practice. The limitations of traditional Chinese medicine foot bath: The biggest obstacle for traditional Chinese medicine ingredients to exert their effects through skin absorption is the skin itself. However, due to the existence of the stratum corneum barrier, the efficacy of the transdermal drug delivery system is essentially limited. Therefore, to maximize the absorption of effective ingredients through the skin and develop a transdermal drug delivery system for foot bath is also an innovative therapy for traditional Chinese medicine, with a huge demand.

[0004] Ultrasound - enhanced transdermal drug delivery promotes the penetration of drug molecules through the skin under the action of ultrasonic waves. The mechanisms of ultrasound - enhanced transdermal drug delivery include cavitation effect, thermal effect, convective transport, and mechanical effect. Ultrasound - mediated iontophoresis rearranges the lipid particles in the skin and tissue membrane structures from disordered to ordered, generating potential reversible aqueous biological pores, increasing permeability, promoting the transport of drug molecules from outside the cells to inside the cells, and enabling drug particles to obtain kinetic energy to move along the direction of sound wave propagation. The ultrasound - enhanced transdermal drug delivery technology has both effectiveness and safety. The penetration process has no requirement for molecular polarity, and hydrophilic / hydrophobic, small - molecule / large - molecule substances can all be introduced. Commonly used ultrasound - electrophoresis frequencies are usually divided into two groups: (1) low - frequency ultrasound - mediated iontophoresis (LFS), including frequencies in the range of 20 - 200 kHz, and (2) high - frequency ultrasound - mediated iontophoresis (HFS), including frequencies in the range of 0.7 - 16 MHz. The most common therapeutic ultrasound frequency is 1 - 3 MHz. Compared with single - frequency ultrasound treatment, multi - frequency ultrasound excitation can significantly enhance the acoustic cavitation effect, effectively penetrate biological tissues with minimal energy attenuation, making it very suitable for enhancing transdermal drug delivery.

[0005] In the present invention, by developing a dual - frequency ultrasonic foot bath basin for traditional Chinese medicine health care and nourishment, the traditional Chinese medicine extract or extract is incorporated into the foot bath liquid, and the feet are immersed in it. At this time, the medicinal liquid becomes the contact substance for indirect ultrasonic treatment. The ultrasonic wave is used to introduce the foot bath water medium containing traditional Chinese medicine extract, enabling various factors such as the effective components of traditional Chinese medicine, ultrasonic waves, meridians, and acupoints to play a synergistic therapeutic role. Summary of the Invention

[0006] The object of the present invention is to address the problem that in the existing traditional Chinese herbal medicine foot bath for health care, the percutaneous penetration effect of traditional Chinese herbal medicine is weak and the health care efficacy of traditional Chinese medicine foot bath cannot be maximally exerted. A dual - frequency ultrasonic foot bath basin for traditional Chinese medicine health care and nourishment is designed, which can utilize the dual - frequency ultrasonic waves of the foot bath basin during the foot bath process to enable the effective components of traditional Chinese herbal medicine to be transdermally absorbed by contacting the foot skin and the sole acupoints and meridians, and at the same time stimulate the acupoints and meridians to achieve good therapeutic and health care effects, having strong practical value.

[0007] The technical solution of the present invention is as follows:

[0008] A dual - frequency ultrasonic foot bath basin for traditional Chinese medicine health care and nourishment, characterized in that: a heating and constant - temperature device (5), a control panel (4), 20 dual - frequency ultrasonic vibrators (1, 3), and an ultrasonic generator (6) are electrically connected inside the foot bath basin; there are a total of 20 dual - frequency ultrasonic vibrators. One group is located in the foot - shaped groove (2) of the foot bath basin, corresponding to the positions of the sole reflex areas, with 8 on each of the left and right feet; the other group is on the front and rear inner walls of the foot bath basin, and 4 dual - frequency ultrasonic vibrators are respectively arranged below the water lines in the anterior dorsal foot area, posterior foot area, left lateral area, and right lateral area, and are connected in parallel and then electrically connected to the ultrasonic generator. The dual - frequency ultrasonic vibrators correspond to the foot reflex areas and acupoints, and through frequency adjustment, the synergistic effect of percutaneous drug penetration and meridian stimulation is achieved.

[0009] The dual-frequency ultrasonic vibrator is circular or square, with a size ranging from 1 square centimeter to 10 square centimeters.

[0010] The described dual-frequency ultrasonic vibrator alternates between low frequency: 20–200 kHz and high frequency 1–3 MHz, with an action time ratio of 99:1 - 1:99; the duty cycle is 0, 1:1, 1:4 or 1:8; the ultrasonic intensity is 0.1–2 W / cm2; the duration is 5 - 20 minutes; the power of each dual-frequency ultrasonic vibrator is adjustable, with a power adjustment range of 0.1–10 W, and the ultrasonic vibrator is connected to an ultrasonic generator.

[0011] The described dual-frequency ultrasonic vibrator alternately acts with a low frequency of 20 kHz and a high frequency of 1 MHz, with an action time ratio of 1:9; the duty cycle is 20%; the ultrasonic intensity is 0.5 W / cm2; the duration is preferably 10 minutes; the power of the dual-frequency ultrasonic vibrator is 1 - 3 W per unit.

[0012] The dual-frequency ultrasonic vibrator corresponding to the position of the sole reflex area can strengthen the ultrasonic power of the dual-frequency ultrasonic vibrator at the corresponding reflex area position through a controller according to the needs of reflex area stimulation and transdermal drug delivery through acupoints.

[0013] During foot bath, add Chinese herbal foot bath liquid, adjust the heating water temperature of the heater, put both feet into the foot bath bucket, and start different operating modes of the dual-frequency ultrasonic system, which has significant acupoint stimulation and ultrasonic permeation enhancement effects, can increase the transdermal absorption of active ingredients in the foot bath liquid, and has therapeutic and health care effects on hyperuricemia, hypertension, and insomnia.

[0014] The described Chinese herbal foot bath liquid is prepared from yellow rice wine distiller's grains and a combined raw material of traditional Chinese medicine. The mass ratio of the yellow rice wine distiller's grains to the combined raw material of traditional Chinese medicine is 5:6 - 5:10. The traditional Chinese medicine composition includes: Ficus pumila L., Lygodium japonicum (Thunb.) Sw., and Orthosiphon aristatus (Blume) Miq.

[0015] It should be noted that the parameters of the dual-frequency ultrasonic element of the dual-frequency ultrasonic foot bath basin for traditional Chinese medicine health care and health preservation of the present invention include: treatment time, sound intensity, duty cycle, working frequency, and effective action area of the sound head.

[0016] 1) Ultrasonic action time: The longer the ultrasonic time, the greater the cumulative treatment dose, and the greater the mechanical effect and thermal effect. However, usually, the safe treatment time per session is not more than 20 minutes.

[0017] 2) Duty cycle: This refers to the working mode of the ultrasonic wave. The working mode with a 100% duty cycle is the continuous mode, which means that ultrasonic waves are continuously output without interruption for a duration of usually 10 milliseconds, resulting in a relatively large stimulation amount and significant tissue temperature rise. Other modes with a duty cycle less than 100% are called pulse modes. Taking the most commonly used 20% duty cycle as an example, pulsed ultrasonic waves are output for 2 milliseconds and interrupted for 8 milliseconds within a 10-millisecond duration. The stimulation amount is relatively small, the tissue temperature rises gently, and it is easy to tolerate.

[0018] 3) Sound intensity and ultrasonic probe position: The greater the sound intensity, that is, the greater the stimulation amount, the higher the tissue temperature rise in the acting area. Usually, the safe treatment dose ranges from 0 - 2.0 watts per square centimeter (continuous wave) to 0 - 2.5 watts per square centimeter (pulse wave). There are more than 300 acupoints and 67 reflex zones on the foot, which is the focus of the three yang meridians and three yin meridians. The three yin meridians are intricately connected to the human organs and the overall meridian system. There is an interaction between the traditional Chinese medicine foot reflex zones and the transdermal drug delivery system. According to different diseases of foot bath patients, the present invention enhances the ultrasonic power of the ultrasonic elements corresponding to the sole acupoints at the bottom of the foot bath basin to strengthen acupoint drug delivery and acupoint physical stimulation. For example, for hypertension patients, the controller enhances the power intensity of the ultrasonic elements near Yongquan acupoint, Taichong acupoint, Taibai acupoint, Xingjian acupoint, and Rangu acupoint. For insomnia patients, the controller enhances the power intensity of the ultrasonic elements near Baiqiao acupoint and Yongquan acupoint, which has good safety and effectiveness.

[0019] 4) Working frequency: The present invention combines low-frequency ultrasound (ranging from 20 to 200 kHz) with high-frequency ultrasound (ranging from 1 to 3 MHz) to form ultrasonic elements, which are installed at the bottom and around the foot bath basin. Preferably, the low frequency is 20 kHz and the high frequency is 1 MHz alternating, and the action time ratio is preferably 1:9.

[0020] 5) Effective acting area: The common effective areas of ultrasonic heads are 1, 2, 4, and 10 square centimeters. The ultrasonic probes supporting the foot bath basin can select ultrasonic heads of different area sizes for the bottom and around the foot bath basin.

[0021] All the above parameters intersect with each other to form a reasonable treatment dose. Dose energy = (sound intensity) × (action time) × (duty cycle). This dose should take into account safety, tolerance, effectiveness, and operation efficiency as much as possible according to the different requirements for treating diseases.

[0022] The beneficial effects of the present invention are:

[0023] The present invention can be used for health care of Chinese herbal foot bath. During foot bath, add Chinese herbal foot bath liquid, adjust the heating water temperature of the heater, put both feet into the foot bath bucket, and start different operation modes of the dual-frequency ultrasonic system, which has significant acupoint stimulation and ultrasonic penetration promoting effects, can increase the transdermal absorption of active ingredients in the foot bath liquid, and has good therapeutic and health care effects on various diseases such as hyperuricemia, hypertension, and insomnia.

[0024] The dual-frequency ultrasonic foot bath basin for traditional Chinese medicine health care and preservation of the present invention has the following beneficial effects in realizing the health care and treatment effects on various diseases through the combination of Chinese herbal foot bath and transdermal penetration promoting technology:

[0025] 1) The dual-frequency ultrasonic effectively promotes the absorption of bioactive compounds of Chinese herbal medicines in the foot bath liquid through the mucous membranes, sweat glands and hair follicles of the skin, so as to enter the body and achieve therapeutic effects. It overcomes the disadvantage of low transdermal absorption efficiency of drug components in ordinary Chinese herbal foot bath, and the use frequency is controlled within a safe range, and it will not damage the skin barrier, and no adverse reactions and side effects are seen.

[0026] 2) The transdermal absorption of active ingredients of Chinese herbal medicines in foot bath avoids the first-pass effect of oral Chinese medicines, as well as the unpleasant taste and smell, which may cause patients to become non-compliant, and the treatment method is simple.

[0027] 3) According to the theory of traditional Chinese medicine meridian conduction and modern foot reflex zone theory, the stimulation of foot acupoints by ultrasonic elements at the bottom of the Chinese herbal foot bath basin can dredge the meridians and strengthen the therapeutic and regulatory effects on the reflex zones. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 is a schematic cross-sectional structure diagram of the present invention.

[0029] Figure 2 is a top view of the arrangement of ultrasonic vibrators of the present invention (the ultrasonic vibrators corresponding to the reflection zones in the grooves, 8 ultrasonic vibrators for each of the left and right feet corresponding to the disease reflection zones, respectively 1-16, a total of 16).

[0030] Figure 3 is a position diagram of the ultrasonic vibrator 3 corresponding to the foot-shaped groove reflection zone at the bottom of the basin of the present invention.

[0031] Figure 4 is a schematic diagram of the container for percutaneous penetration measurement.

[0032] Figure 5 is an absorbance-Evans blue concentration standard curve.

[0033] In the figure: 1 is the inner wall ultrasonic oscillator: there is 1 each in the dorsal area of the forefoot 1-1, the posterior area of the foot 1-2, the left lateral area 1-3, and the right lateral area 1-4; 2 is the pelvic floor foot-shaped groove; 3 is the ultrasonic oscillator corresponding to the reflection area of the pelvic floor foot-shaped groove (the position of the sole reflection area, 8 on each of the left and right feet); 4 is the control panel; 5 is the heating and constant temperature device; 6 is the ultrasonic generator. Specific embodiments

[0034] The present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments.

[0035] As Figures 1 - 3 shown.

[0036] A dual-frequency ultrasonic foot bath for traditional Chinese medicine health care and health preservation, as Figure 1 shown, includes a foot bath body 7 and a control panel 4. An electrically connected heating and constant temperature device 5, dual-frequency ultrasonic oscillators 1, 3, and an ultrasonic generator 6 are provided inside the foot bath body 7. The control panel 4 is installed on the panel installation area 8 of the foot bath body 7. The total number of the dual-frequency ultrasonic oscillators 1, 3 is 20, which are circular or square, with a size of about 1 square centimeter to 10 square centimeters. One group is in the foot-shaped groove 2 at the bottom of the inner cavity of the foot bath body 7, corresponding to the position of the sole reflection area, 8 on each of the left and right feet; the other group is in the front, rear, left, and right inner walls of the foot bath body 7, and there are a total of 4 dual-frequency ultrasonic oscillators below the water line in the dorsal area of the forefoot 1-1, the posterior area of the foot 1-2, the left lateral area 1-3, and the right lateral area 1-4. After being connected in parallel, they are electrically connected to the ultrasonic generator. The dual-frequency ultrasonic oscillators correspond to the foot reflection areas and acupoints, and achieve the synergistic effect of transdermal drug penetration and meridian stimulation through frequency adjustment.

[0037] The above-mentioned dual-frequency ultrasonic oscillator uses low frequency: 20–200 kHz and high frequency 1–3 MHz alternately, with the action time ratio of 99:1 - 1:99; the duty cycle can be selected as 0, 1:1, 1:4, 1:8; the ultrasonic intensity is 0.1–2 W / cm2; the duration is (5 - 20 minutes); the power of each dual-frequency ultrasonic oscillator is adjustable, and the power adjustment range is 0.1–10 w. The ultrasonic oscillator is connected to the ultrasonic generator.

[0038] The above-mentioned dual-frequency ultrasonic oscillator preferably uses low frequency: 20 kHz and high frequency 1 MHz alternately, with the action time ratio preferably 1:9; the duty cycle is preferably 20%; the ultrasonic intensity is preferably 0.5 W / cm2; the duration is preferably 10 minutes); the power of the dual-frequency ultrasonic oscillator is preferably 1 - 3 W / each.

[0039] The dual-frequency ultrasonic foot bath basin for traditional Chinese medicine health preservation of the present invention is used for foot bath health care with traditional Chinese herbs. When taking a foot bath, add traditional Chinese herbal foot bath liquid, adjust the heating water temperature of the heater to 40-42 °C, put both feet into the foot bath bucket, soak for 30-40 minutes, and start different operating modes of the dual-frequency ultrasonic system. It has significant acupoint stimulation and ultrasonic penetration-promoting effects, can increase the transdermal absorption of active ingredients in the foot bath liquid, and has good therapeutic and health care effects on various diseases such as hyperuricemia, hypertension, and insomnia.

[0040] It should be noted that the dual-frequency ultrasonic oscillator parameters of the dual-frequency ultrasonic foot bath basin for traditional Chinese medicine health preservation of the present invention include: treatment time, sound intensity, duty cycle, working frequency, and effective action area of the sound head.

[0041] 1) Ultrasonic action time: The longer the ultrasonic time, the greater the cumulative treatment dose, and the greater the mechanical effect and thermal effect. However, usually the safe treatment time per time is not more than 20 minutes.

[0042] 2) Duty cycle: That is, the working mode of ultrasonic waves. The working mode with a duty cycle of 100% is the continuous mode, that is, usually continuous ultrasonic waves are output without interruption in a duration of 10 milliseconds, the stimulation amount is large, and the tissue temperature rise is significant. Other modes with a duty cycle less than 100% are called pulse modes. Taking the most commonly used duty cycle of 20% as an example, pulsed ultrasonic waves with a working duration of 2 milliseconds and an intermittent duration of 8 milliseconds are output in a duration of 10 milliseconds. The stimulation amount is relatively small, the tissue temperature rise is gentle, and it is easy to tolerate.

[0043] 3) Sound intensity and ultrasonic probe position: The greater the sound intensity, that is, the greater the stimulation amount, and the higher the tissue temperature rise in the action area. Usually, the safe treatment dose is 0-2.0 watts per square centimeter (continuous wave) to 0-2.5 watts per square centimeter (pulse wave). There are more than 300 acupoints and 67 reflex zones on the foot, which is the focus of the three yang meridians and three yin meridians. The three yin meridians are intricately connected with human organs and the overall meridian system. There is an interaction between the traditional Chinese medicine foot reflex zones and the transdermal drug delivery system. According to different diseases of foot bath patients, the present invention enhances the ultrasonic power of the ultrasonic oscillators corresponding to the foot sole reflex zones at the bottom of the foot bath basin, and strengthens acupoint drug delivery and acupoint physical stimulation. For example, for hypertensive patients, the controller enhances the power intensity of the ultrasonic oscillators near Yongquan acupoint, Taichong acupoint, Taibai acupoint, Xingjian acupoint, and Rangu acupoint. For insomnia patients, the controller enhances the power intensity of the ultrasonic oscillators near Baiqiao acupoint and Yongquan acupoint, which has good safety and effectiveness.

[0044] 4) Working frequency: The present invention combines low-frequency ultrasound (ranging from 20 to 200 kHz) with high-frequency ultrasound (ranging from 1 to 3 MHz) to form ultrasonic oscillators, which are installed at the bottom and around the foot bath basin. Preferably, the low frequency is 20 kHz and the high frequency is 1 MHz alternately, and the action time ratio is preferably 1:9;

[0045] 5) Effective working area: The common effective areas of ultrasonic heads are 1, 2, 4, and 10 square centimeters. For the ultrasonic probe supporting the foot bath basin, ultrasonic heads with different areas can be selected and used at the bottom and around the foot bath basin.

[0046] All the above parameters crisscross to form a reasonable treatment dose. Dose energy = (acoustic intensity) × (action time) × (duty cycle). This dose should take into account safety, tolerance, effectiveness, and operation efficiency as much as possible according to the different diseases to be treated.

[0047] The disease reflection areas corresponding to the dual-frequency ultrasonic vibrators are shown in the following table.

[0048] Positions of Ultrasonic Vibrators in Foot Bath Basin and Disease Reflection Areas

[0049]

[0050]

[0051] When taking a foot bath, it is necessary to add Chinese herbal foot bath liquid, adjust the heating water temperature of the heater, put both feet into the foot bath bucket, and start different operating modes of the dual-frequency ultrasonic system. It has significant acupoint stimulation and ultrasonic penetration enhancement effects, can increase the transdermal absorption of active ingredients in the foot bath liquid, and has therapeutic and health care effects on hyperuricemia, hypertension, and insomnia. The Chinese herbal foot bath liquid described can use the commonly used foot bath liquid on the current market, but it is preferably a foot bath liquid prepared from a combination of yellow rice wine distiller's grains and traditional Chinese medicine raw materials. The mass ratio of the yellow rice wine distiller's grains to the traditional Chinese medicine raw material combination is 5:6 to 5:10. The traditional Chinese medicine composition includes: Ficus pumila L., Lygodium japonicum (Thunb.) Sw., and Clerodendranthus spicatus (Thunb.) C. Y. Wu. The combined extract is prepared by the following method: The yellow rice wine distiller's grains raw material is extracted with an extraction solvent to obtain a yeast / rice bran fermentation product; the traditional Chinese medicine raw material combination is extracted with ethanol-water to obtain a traditional Chinese medicine combined extract. Add the yeast / rice bran fermentation product and a solubilizer to the traditional Chinese medicine combined extract, stir the solution, filter, concentrate under reduced pressure, and then spray dry to obtain the combined extract. The yeast / rice bran fermentation product is prepared by the following preparation method: Take fresh yellow rice wine distiller's grains or frozen-stored yellow rice wine distiller's grains; the yellow rice wine distiller's grains are successively dried and crushed to obtain yellow rice wine distiller's grains fine powder with a water content of less than 5% and a particle size of less than 20 mesh; add an extraction solvent to extract the yellow rice wine distiller's grains fine powder, filter to obtain a yeast / rice bran fermentation product extract, concentrate under reduced pressure to recover the extraction solvent, and obtain the yeast / rice bran fermentation product.

[0052] Evaluation method of the present invention: The present invention uses a modified Franz diffusion cell as a percutaneous penetration measurement container (such as Figure 4As shown). Add 0.01 mol / L PBS (pH 7.4) solution to the receiving pool. Wrap the edge area of the circular porcine ear back skin sample with a radius of 3 cm and a thickness of 3 mm with a gel to prevent leakage, with the stratum corneum facing the outside, and install it on the diffusion cell. The diffusion cell device is inverted on the ultrasonic action element at the bottom of the ultrasonic foot bath basin. Add 8 L of 0.01 mol / L PBS (pH 7.4) solution to the foot bath basin to immerse the Franz diffusion cell. Then add the model drug Evans blue (40 mg; molecular weight = 960.81). Using spectrophotometry, construct a standard curve with the standard product and quantitatively analyze the concentration of Evans blue in the receiving pool, as Figure 5 shown.

[0053] Examples 1, 2, and 3.

[0054] 1) Use a dual-frequency ultrasonic foot bath basin for traditional Chinese medicine health care. The foot bath basin includes a controller, multiple dual-frequency ultrasonic elements, a heating device, and a constant temperature device. Among them, multiple dual-frequency ultrasonic elements (ultrasonic vibrators), one group is at the bottom of the foot bath basin, corresponding to the positions of the sole acupoints, 8 on each side, circular in shape, each with an area of 1 square centimeter, and the other group is in the front and back below the water line in the foot bath basin, a total of 4 on the left and right, each with an area of 10 square centimeters. After connection, they are electrically connected to the ultrasonic generator;

[0055] 2) According to the above evaluation method, place the Franz diffusion cell and the test sample solution in the foot bath basin, turn on the foot bath basin and heat it to 43 °C. After 5 minutes of action at the parameters of each example respectively, maintain 43 °C and continue to soak for 30 minutes, then take the sample solution in the receiving pool, measure the absorbance, and calculate the concentration of Evans blue in the sample solution of the receiving pool (μg / ml). The percutaneous penetration measurement results of different frequencies of ultrasonic waves in Examples 1, 2, and 3 are shown in Table 1:

[0056] Table 1 Percutaneous penetration measurement results of different frequencies of ultrasonic waves in Examples 1, 2, and 3

[0057]

[0058] Considering the safety of dose energy output and the percutaneous penetration effect, using an alternating ratio of 20 kHz and 1 MHz of 1:9 has a better effect and relatively low dose energy.

[0059] Example 4.

[0060] The dual-frequency ultrasonic foot bath basin for traditional Chinese medicine health care is used for the health care foot bath of patients with hyperuricemia:

[0061] Inclusion criteria for the test population: Serum uric acid >8 mg / dl (476 μmol / L); age range from 35 to 65 years old, gender is not restricted; no relevant therapeutic drugs (such as benzbromarone, allopurinol, probenecid, etc.) were taken within one month before the test, and a high-purine diet was controlled for one week.

[0062] In this study, 80 subjects with hyperuricemia with a serum uric acid > of 8 mg / dl were selected and divided into a control group of 40 cases and a test group of 40 cases. All met the inclusion criteria for the test population. The changes in serum uric acid levels of the subjects before and after treatment were observed, and the adverse events occurring in the soles of the feet and feet were recorded.

[0063] Cure: Serum uric acid returns to normal.

[0064] Marked effect: The decrease in serum uric acid is > 25% compared with that before treatment.

[0065] Effective: The decrease in serum uric acid is > 15% compared with that before treatment.

[0066] Ineffective: The decrease in serum uric acid is < 15% compared with that before treatment.

[0067] Statistical method: The data were processed using SPSS 23.0 statistical software. Measurement data were expressed as mean ± standard deviation (x ± s) and t-test was used; count data were expressed as rate (%) and x-test was used. P < 0.05 indicated that the difference was statistically significant.

[0068] The test methods for the 40 cases in the test group are as follows:

[0069] 1) A dual-frequency ultrasonic foot bath for traditional Chinese medicine health preservation is used. The foot bath includes a controller, multiple dual-frequency ultrasonic elements, a heating device, and a constant temperature device. Among them, multiple dual-frequency ultrasonic elements (ultrasonic vibrators), one group is at the bottom of the foot bath, corresponding to the positions of the acupoints on the soles of the feet, 8 on each side, circular in shape, each with an area of 1 square centimeter, and the other group is in the front and back below the water line in the foot bath, a total of 4 on the left and right, each with an area of 10 square centimeters. After connection, they are electrically connected to the ultrasonic generator;

[0070] 2) The controller is used to set the heating constant temperature at 43 °C, the frequencies of the dual-frequency ultrasonic elements, low frequency: 20 kHz and high frequency 1 MHz alternate, the preferred ratio of the action time is 1:9; the preferred duty cycle is 20%; the preferred ultrasonic intensity is 0.5 W / cm 2 ; the preferred duration is 10 minutes; the power of the ultrasonic element at the Yongquan acupoint is 20 W, and the power of the dual-frequency ultrasonic elements at other positions is selected as 5 W.

[0071] 3) 8 L of traditional Chinese medicine extract for reducing uric acid is added to the foot bath (the traditional Chinese medicine extract is prepared by boiling 20 g of Saposhnikovia divaricata, 20 g of Anemarrhena asphodeloides, 10 g of Ligusticum wallichii, 30 g of Smilax glabra, 10 g of Angelica sinensis, and 10 g of Forsythia suspensa in 2 L of water, filtering after extraction, and then making the filtrate up to 8 L with water);

[0072] 4) The foot bath basin heats the traditional Chinese medicine extract and raises the temperature to 43°C. The subjects' feet are placed in the basin. Press the start button of the ultrasonic system, turn it off after 10 minutes, and soak the feet for 30 minutes.

[0073] In the 40 cases of the control group, the dual-frequency ultrasound was not turned on, and other steps were carried out according to the above test method.

[0074] Using the above foot bath method, 2 weeks is one course of treatment, once a day. Treat continuously for 4 weeks. Measure the change in serum uric acid of the subjects once before treatment, after 1 course of treatment, and after 2 courses of treatment to evaluate the curative effect.

[0075] Test results:

[0076] 1) After two courses of foot bath with the traditional Chinese medicine extract using the dual-frequency ultrasound foot bath basin for health care in traditional Chinese medicine, the serum uric acid level of the subjects decreased significantly. See Table 2 below for the comparison of the serum uric acid levels of the subjects before and after below the water line in the foot bath basin (x±s, umol / L).

[0077] Table 2 Serum uric acid levels before and after treatment in Example 4

[0078]

[0079] Note: * Compared with before treatment, P < 0.05; # Compared with the control group, P < 0.05

[0080] 2) After the first course of foot bath with the traditional Chinese medicine extract using the dual-frequency ultrasound foot bath basin for health care in traditional Chinese medicine, 14 cases (35.0%) were cured, 16 cases (40.0%) showed marked improvement, 6 cases (15.0%) were effective, and 4 cases (10%) were ineffective. The total effective rate was 90.0% and the cure rate was 35.0%. After the second course of treatment for the subjects, 25 cases (62.5%) were cured, 11 cases (27.5%) showed marked improvement, 3 cases (7.5%) were effective, and 1 case (2.5%) was ineffective. The total effective rate was 97.5% and the cure rate was 62.5%. See Table 3.

[0081] Table 3 Evaluation form of treatment effect in Example 4

[0082]

[0083] Using the dual-frequency ultrasound foot bath basin for health care in traditional Chinese medicine for foot bath has achieved satisfactory curative effect in reducing uric acid clinically. The effective rate is over 97%. The effective rate and cure rate are significantly higher than those of the foot bath basin without dual-frequency ultrasound, and no adverse reactions are seen. It is a major innovation in foot bath health care treatment for hyperuricemia, with strong health care application value and significant economic and social benefits.

[0084] Example 5:

[0085] The dual-frequency ultrasound foot bath basin for health care in traditional Chinese medicine is used for the health care foot bath of patients with hypertension:

[0086] Inclusion criteria for the test population: Anyone with long-term blood pressure, where the systolic blood pressure is higher than 140 mmHg and the diastolic blood pressure is higher than 90 mmHg, shall be used as the standard for selecting cases; the age range is 35 - 65 years old, and the gender is not limited; no relevant treatment drugs have been taken within one month before the test.

[0087] In this study, 80 subjects meeting the above inclusion criteria were selected and divided into a control group of 40 cases and a test group of 40 cases. The changes in serum uric acid levels of the subjects before and after treatment were observed, and the adverse events occurring in the soles and feet were recorded.

[0088] Marked effect: The diastolic blood pressure drops by more than 10 mmHg and reaches the normal range; although the diastolic blood pressure does not drop to the normal level, it has dropped by 20 mmHg or more. One of these conditions must be met.

[0089] Effective: The diastolic blood pressure drops by less than 10 mmHg but reaches the normal range; the diastolic blood pressure drops by 10 - 19 mmHg but does not reach the normal range.

[0090] Ineffective: Does not meet the above criteria.

[0091] Statistical method: The SPSS 23.0 statistical software was used to process the data. Measurement data were expressed as the mean ± standard deviation (x ± s), and the t-test was used; count data were expressed as a rate (%), and the chi-square test was used. P < 0.05 indicates that the difference is statistically significant.

[0092] The test method for the 40 cases in the test group is as follows:

[0093] 1) A dual-frequency ultrasonic foot bath basin for traditional Chinese medicine health preservation is used. The foot bath basin includes a controller, multiple dual-frequency ultrasonic elements, a heating device, and a constant temperature device. Among them, multiple dual-frequency ultrasonic elements (ultrasonic vibrators), one group is at the bottom of the foot bath basin, corresponding to the positions of the sole acupoints, 8 on each side, circular in shape, each with an area of 1 square centimeter, and the other group is in the front and back below the water line in the foot bath basin, a total of 4 on the left and right, each with an area of 10 square centimeters. After connection, they are electrically connected to the ultrasonic generator;

[0094] 2) The controller is used to set the heating constant temperature at 43 °C, the frequency of the dual-frequency ultrasonic elements, low frequency: 20 kHz and high frequency 1 MHz alternate, the action time ratio is preferably 1:9; the duty cycle is preferably 20%; the ultrasonic intensity is preferably 0.5 W / cm 2 ; the duration is preferably 10 minutes; the power of the ultrasonic element at the Yongquan acupoint is 20 w, and the power of the dual-frequency ultrasonic elements at other positions is selected as 5 W.

[0095] 3) Add 8 L of traditional Chinese medicine extract for reducing blood pressure (the traditional Chinese medicine extract is prepared by boiling 20 g of Poria cocos, 10 g of Atractylodes macrocephala, 30 g of Cinnamomum cassia, 30 g of Curcuma aromatica Salisb., 30 g of Taxillus sutchuenensis (Lecomte) Danser, 15 g of Pueraria lobata (Willd.) Ohwi, 30 g of Paeonia lactiflora Pall., and 30 g of Uncaria rhynchophylla (Miq.) Miq. ex Havil. in 2 L of water, filtering after extraction, and making the filtrate up to 8 L with water) into the foot bath basin;

[0096] 4) Heat the traditional Chinese medicine extract in the foot bath basin, raise the temperature to 43 °C, place the subjects' feet in the basin, press the start button of the ultrasonic system, turn it off after 10 min, and soak the feet for 30 minutes.

[0097] For the 40 cases in the control group, the dual-frequency ultrasound is not turned on, and the other steps are carried out according to the above test method.

[0098] Adopt the above foot bath method, with 2 weeks as one course of treatment, once a day. Continuously treat for 4 weeks, and measure the blood pressure of the subjects once before treatment, after 1 course of treatment, and after 2 courses of treatment to evaluate the curative effect.

[0099] Test results:

[0100] 1) After two courses of foot bath with the traditional Chinese medicine extract (the traditional Chinese medicine extract for reducing blood pressure) using the dual-frequency ultrasound foot bath basin for traditional Chinese medicine health care and preservation, the blood pressure level of the subjects decreased significantly. See Tables 4 and 5 for the comparison of the blood pressure levels of the subjects before and after under the water line in the foot bath basin (x±s, mmHg).

[0101] Table 4 Systolic blood pressure levels before and after treatment in Example 5

[0102]

[0103] Table 5 Diastolic blood pressure levels before and after treatment in Example 5

[0104]

[0105] Note: * Compared with before treatment, P < 0.05; # Compared with the control group, P < 0.05

[0106] 2) After the first course of foot bath with the traditional Chinese medicine extract (the traditional Chinese medicine extract for reducing blood pressure) using the dual-frequency ultrasound foot bath basin for traditional Chinese medicine health care and preservation, 9 cases (22.5%) showed marked effect, 23 cases (57.5%) showed effective, and 8 cases (20%) showed ineffective, with a total effective rate of 75.0%; after the second course of treatment, 18 cases (45.0%) showed marked effect, 19 cases (47.5%) showed effective, and 3 cases (7.5%) showed ineffective, with a total effective rate of 92.5%. See Table 6.

[0107] Table 6 Evaluation form of treatment effect in Example 5

[0108]

[0109] Using the foot bath with traditional Chinese medicine extracts (blood pressure-lowering traditional Chinese medicine extract) in a dual-frequency ultrasonic foot bath for traditional Chinese medicine health care and preservation, satisfactory blood pressure-lowering effects have been achieved clinically, with an effective rate of over 90%. The effective rate and cure rate are significantly higher than those of foot baths without dual-frequency ultrasound, and no adverse reactions have been observed. It is a major innovation in foot bath health care for treating hypertension, with strong health care application value and significant economic and social benefits.

[0110] Example 6:

[0111] The dual-frequency ultrasonic foot bath for traditional Chinese medicine health care and preservation is used for the health care foot bath of insomnia patients:

[0112] Inclusion criteria for the test population: Refer to the "Diagnostic and Therapeutic Criteria for Traditional Chinese Medicine Diseases" (promulgated by the State Administration of Traditional Chinese Medicine); those with mild difficulty in falling asleep or waking up easily and not being able to fall asleep again after waking up, and those with severe cases being unable to fall asleep all night; often accompanied by symptoms such as headache, dizziness, palpitation, amnesia, and dreaminess; no abnormalities were found through various system and laboratory examinations; during the test period, taking relevant treatment drugs was prohibited, emotional stimulation was avoided, and life should be regular.

[0113] In this study, 80 subjects who met the above inclusion criteria were selected and divided into a control group of 40 cases and a test group of 40 cases. The changes in the sleep quality of the subjects before and after treatment were observed, and the adverse events occurring on the soles of the feet and feet were recorded.

[0114] Refer to the efficacy judgment criteria in the "Guiding Principles for Clinical Research of New Traditional Chinese Medicines":

[0115] Cured: Easy to fall asleep or the sleep returns to normal, can sleep for more than 7 hours every night, and the self-conscious symptoms basically disappear;

[0116] Markedly effective: The sleep is significantly improved, it is easier to fall asleep, can sleep for more than 5 hours every night, and most of the self-conscious symptoms are relieved;

[0117] Effective: Can still fall asleep after treatment, the sleep duration is extended by 2 - 3 hours, the self-conscious symptoms are alleviated compared with before, or there is occasional mild recurrence;

[0118] Ineffective: The sleep condition and self-conscious symptoms have not improved after treatment

[0119] Statistical method: The data were processed using SPSS 23.0 statistical software. Measurement data were expressed as the mean ± standard deviation (x ± s), and the t-test was used; count data were expressed as the rate (%), and the x-test was used. P < 0.05 indicates that the difference is statistically significant.

[0120] The test method for the 40 cases in the test group is as follows:

[0121] 1) Use a dual-frequency ultrasonic foot bath basin for traditional Chinese medicine health preservation. The foot bath basin includes a controller, multiple dual-frequency ultrasonic elements, a heating device, and a constant temperature device. Among them, there are multiple dual-frequency ultrasonic elements (ultrasonic vibrators). One group is at the bottom of the foot bath basin, corresponding to the positions of the sole acupoints, 8 on each side, in a circular shape, with each having an area of 1 square centimeter. The other group is in the front and back below the water line in the foot bath basin, a total of 4 on the left and right, each with an area of 10 square centimeters. After connection, they are electrically connected to the ultrasonic generator;

[0122] 2) Set the heating constant temperature to 43°C through the controller. For the frequency of the dual-frequency ultrasonic elements, the low frequency: 20 kHz and the high frequency 1 MHz alternate. The preferred ratio of the action time is 1:9; the preferred duty cycle is 20%; the preferred ultrasonic intensity is 0.5 W / cm 2 ; The preferred duration is 10 minutes; the power of the ultrasonic elements at the Yongquan acupoint and Baiqiao acupoint positions is 20 w, and the power of the dual-frequency ultrasonic elements at other positions is selected as 5 W.

[0123] 3) Add 8L of sleep-aiding traditional Chinese medicine extract to the foot bath basin (the traditional Chinese medicine extract is made from 20g of green tangerine peel, 20g of bupleurum root, 20g of polygala root, 10g of forsythia, 20g of albizia bark, 10g of safflower, 20g of angelica, 10g of polygonum multiflorum thunb, and 10g of atractylodes macrocephala. Boil with 2L of water, filter, and make the filtrate up to 8L with water);

[0124] 4) Heat the traditional Chinese medicine extract (sleep-aiding traditional Chinese medicine extract) in the foot bath basin to 43°C. Place the subject's feet in the basin, press to start the ultrasonic system, turn it off after 10 minutes, and soak in the foot bath for 30 minutes.

[0125] For 40 cases in the control group, the dual-frequency ultrasonic is not turned on, and other steps are carried out according to the above test method.

[0126] Adopt the above foot bath method, with 2 weeks as one course of treatment, once a day. Continuously treat for 4 weeks, record the sleep quality before treatment, after 1 course of treatment, and after 2 courses of treatment, and evaluate the curative effect.

[0127] Test results:

[0128] After the first course of treatment with the dual-frequency ultrasonic foot bath basin for traditional Chinese medicine health preservation using the traditional Chinese medicine extract (sleep-aiding traditional Chinese medicine extract), 5 cases were cured (12.5%), 9 cases showed marked improvement (22.5%), 20 cases were effective (50.0%), 6 cases were ineffective (15.0%), the total effective rate was 85.0%, and the cure rate was 12.5%; after the second course of treatment, 18 cases were cured (45.0%), 12 cases showed marked improvement (30.0%), 7 cases were effective (17.5%), 3 cases were ineffective (7.5%), the total effective rate was 92.5%, and the cure rate was 45.0%, as shown in Table 7.

[0129] Table 7 Comparison of the foot bath curative effects of the subjects:

[0130]

[0131] Using the traditional Chinese medicine extract for foot bath with a dual - frequency ultrasonic foot bath basin for traditional Chinese medicine health care and preservation, satisfactory sleep - promoting curative effects have been achieved clinically. The effective rate is as high as over 90%. The effective rate and cure rate are significantly higher than those of the foot bath basin without dual - frequency ultrasound, and no adverse reactions have been seen. It is a major innovation in foot bath health care for treating hypertension, has strong health care application value, and remarkable economic and social benefits.

[0132] It should be noted that the above - mentioned specific implementation manners are only used to illustrate the present invention and not to limit the scope of the present invention. After reading the present invention, various equivalent modifications of the present invention by those skilled in the art all fall within the scope defined by the appended claims of this application.

[0133] The parts not involved in the present invention are the same as the prior art or can be realized by using the prior art.

Claims

1. A dual-frequency ultrasonic foot bath for traditional Chinese medicine health care, characterized in that: The footbath is provided with an electrically connected heating thermostat (5), a control panel (4), 20 dual-frequency ultrasonic vibrators (1, 3), and an ultrasonic generator (6); the dual-frequency ultrasonic vibrators are 20 in total, one group is in the foot-shaped groove (2) of the footbath, corresponding to the position of the sole reflex zone, 8 for each left and right foot; the other group is provided with 4 dual-frequency ultrasonic vibrators on the front and back inner walls of the footbath, respectively located below the waterline of the front back area, the rear area, the left lateral area, and the right lateral area, and are electrically connected to the ultrasonic generator after being connected in parallel. The dual-frequency ultrasonic vibrators correspond to the foot reflex zones and acupuncture points, and achieve the synergistic effect of transdermal drug penetration and meridian stimulation through frequency adjustment.

2. The dual-frequency ultrasonic foot bath for traditional Chinese medicine health care and health preservation according to claim 1, characterized in that: The dual-frequency ultrasonic vibrator is round or square in shape and has a size of 1 square centimeter to 10 square centimeters.

3. The dual-frequency ultrasonic foot bath for traditional Chinese medicine health care and health preservation according to claim 1, characterized in that: The dual-frequency ultrasonic vibrator adopts low frequency: 20-200kHz and high frequency 1-3MHz alternately, with an action time ratio of 99:1-1:99; a duty cycle of 0, 1:1, 1:4 or 1:8; an ultrasonic intensity of 0.1-2W / cm2; a duration of 5-20 minutes; the power of each dual-frequency ultrasonic vibrator is adjustable, with a power adjustment range of 0.1-10W, and the ultrasonic vibrator is connected to an ultrasonic generator.

4. The dual-frequency ultrasonic foot bath for traditional Chinese medicine health care and health preservation according to claim 3, characterized in that: The dual-frequency ultrasonic vibrator adopts the alternating action of low frequency 20kHz and high frequency 1MHz, the action time ratio is 1:9; the duty cycle is 20%; the ultrasonic intensity is 0.5W / cm 2 ; The duration is preferably 10 minutes; the power of the dual-frequency ultrasonic vibrator is 1-3W / piece.

5. The dual-frequency ultrasonic foot bath for traditional Chinese medicine health care and health preservation according to claim 1, characterized in that: The dual-frequency ultrasonic vibrator corresponding to the position of the sole reflex zone can enhance the ultrasonic power of the dual-frequency ultrasonic vibrator corresponding to the position of the reflex zone through a controller according to the needs of reflex zone stimulation and acupoint transdermal drug delivery.

6. The dual-frequency ultrasonic foot bath for traditional Chinese medicine health care and health preservation according to claim 1, characterized in that: When bathing your feet, add Chinese herbal foot bath liquid, adjust the water temperature of the heater, put your feet into the foot massage bucket, and start different operating modes of the dual-frequency ultrasound system. It has significant acupoint stimulation and ultrasound-enhanced penetration effects, which can increase the transdermal absorption of active ingredients in the foot bath liquid, and has therapeutic and health-care effects on hyperuricemia, hypertension, and insomnia.

7. The dual-frequency ultrasonic foot bath for traditional Chinese medicine health care and health preservation according to claim 6, characterized in that: The Chinese herbal foot bath liquid is prepared with rice wine lees and Chinese medicinal combination raw materials as raw materials, the mass ratio of the rice wine lees to the Chinese medicinal combination raw materials is 5:6-5:10, and the Chinese medicinal composition comprises: Ficus microcarpa, Lygodium japonicum, and Cat's Whiskers.

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