Ablation device and ablation system
By introducing resonant circuits into the implant of the ablation device and applying an alternating magnetic field outside the independent applicator to generate heat for ablation, the problem of pain caused by electrode insertion and tumor recurrence in the prior art is solved, and a safer and more comfortable ablation treatment effect is achieved.
Patent Information
- Application Number
- CN202411850006.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-16
- Publication Date
- 2025-05-27
AI Technical Summary
When existing radiofrequency ablation and microwave ablation technologies treat malignant organisms such as liver cancer, electrode insertion and fixation cause pain and discomfort in the patient, and tumor recurrence requires re-puncture, increasing the patient's pain.
An ablation device is provided, including an implant and an applicator, a resonant circuit is provided inside the implant, an alternating magnetic field is applied outside the applicator, and the implant generates heat for ablation. The device and the applicator are independent, reducing pain and discomfort to the patient and allowing reusability after one implantation.
It reduces the pain and discomfort of patients during the ablation process, and avoids the pain of re-piercing when tumor recurs, achieving a safer and more comfortable treatment effect.
Smart Images
Figure CN120037592A_ABST
Abstract
Description
Technical Field
[0001] The present application relates to the technical field of medical equipment, and in particular to an ablation device and an ablation system. Background Art
[0002] Radiofrequency ablation (RFA) and microwave ablation are common treatments for liver cancer and other malignant organisms, but these methods have some limitations, such as pain and discomfort during electrode insertion and fixation, and the need for re-puncture when tumors recur. Summary of the invention
[0003] The present application provides an ablation device and an ablation system, which can reduce the pain of patients during ablation.
[0004] In a first aspect, the present application provides an ablation device, which includes: at least one implant for implantation into a target tissue, wherein the implant includes a resonant circuit; and at least one applicator for applying an alternating magnetic field to the resonant circuit outside the target tissue.
[0005] Wherein, the surface of the implant is provided with a protective coating.
[0006] The resonant circuit includes a first coil and a capacitor connected in series end to end, and the applicator is used to apply an alternating magnetic field to the first coil outside the target tissue.
[0007] The capacitance value of the capacitor is between 20000 pF and 25000 pF, and the temperature characteristic of the capacitor varies by less than one fiftieth per million degrees Celsius.
[0008] Wherein, the material of the first coil includes silver.
[0009] Wherein, the applicator includes a second coil and a magnetic core, and the magnetic core is inserted into the second coil.
[0010] The material of the second coil includes copper, and the material of the magnetic core includes ferrite magnetic material.
[0011] Wherein, the applicator is also connected to a water cooling part.
[0012] There are multiple applicators, multiple implants, and a distance between two adjacent applicators is between 15 cm and 25 cm.
[0013] A second aspect of the present application provides an ablation system, which includes the ablation device described in any one of the embodiments.
[0014] Distinct from the prior art, the beneficial effects of the present application are as follows: Through the applicator, an alternating magnetic field is applied to the resonant circuit in the implant. The resonant circuit in the implant generates heat to ablate the target tissue. In contrast to traditional radiofrequency ablation and microwave ablation, electrodes need to be directly inserted into the body and fixed, which can cause pain and discomfort to patients during long-term treatment. However, the implant and the applicator in the present application are independent. Therefore, after the implant is implanted into the target tissue, other tissues of the human body are less likely to feel the implant, and the movement of the applicator will not cause the movement of the implant, so the patient will not feel pain and discomfort. At the same time, the traditional solution has the disadvantage that once the target tissue recurs, re-puncture is required for treatment, which undoubtedly increases the pain of the patient. In the present application, only one implantation is needed. After ablating the target tissue, the implant does not need to be removed. If the target tissue recurs again, the implant can be used for ablation again, thus avoiding the patient from suffering secondary pain. BRIEF DESCRIPTION OF THE DRAWINGS
[0015] To more clearly illustrate the technical solutions in the embodiments of the present application, the following will briefly introduce the drawings required for the description of the embodiments. Obviously, the drawings in the following description are only some embodiments of the present application. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on these drawings, where:
[0016] Figure 1 is a schematic structural diagram of an embodiment of the ablation device of the present application;
[0017] Figure 2 is a schematic structural diagram of an embodiment of the ablation system of the present application. DETAILED DESCRIPTION OF THE EMBODIMENTS
[0018] The following will clearly and completely describe the technical solutions in the embodiments of the present application with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only some embodiments of the present application, rather than all embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative efforts belong to the scope of protection of the present application.
[0019] Refer to Figure 1 , the present application provides an ablation device 10, which includes at least one implant 100 and at least one applicator 200. The implant 100 is used to be implanted into the target tissue 300, and the implant 100 includes a resonant circuit 110; the applicator 200 is used to apply an alternating magnetic field to the resonant circuit 110 outside the target tissue.
[0020] Specifically, the implant 100 and the applicator 200 are two independent components that do not come into contact with each other. When using the ablation device 10, the implant 100 needs to be implanted into the target tissue 300, which can be cancer cells, malignant organisms, etc. The applicator 200 is outside the target tissue 300 and does not contact the implant 100. The applicator 200 provides an alternating magnetic field. After the resonant circuit 110 in the implant 100 senses the alternating magnetic field, an induced current is generated in the resonant circuit 110, thereby generating heat and transferring the heat difference to the target tissue 300, and then inactivating the target tissue 300 by means of thermal ablation.
[0021] It can be understood that, compared with traditional radiofrequency ablation and microwave ablation technologies, the electrode needs to be directly inserted into the body and fixed, which will cause pain and discomfort to the patient during a long-term treatment process. However, the implant 100 and the applicator 200 of the present application are independent, and there is a time interval between them when they are used. Therefore, after the implant 100 is implanted into the target tissue 300, other tissues of the human body will not feel the implant 100 and will not feel pain and discomfort. When moving the external applicator 200, it will not cause the movement of the implant 100. At the same time, the traditional solution has the disadvantage that when the target tissue 300 recurs, re-puncture is required for treatment, which undoubtedly increases the pain of the patient. However, the present application only needs to be implanted once. After ablating the target tissue 300, it can be left in place. If the target tissue 300 recurs again, the implant 100 can be used for ablation again, thus avoiding the patient from suffering secondary pain.
[0022] In one embodiment, the surface of the implant 100 is provided with a protective coating.
[0023] Specifically, the protective coating can isolate the resonant circuit 110 in the implant 100 from the external environment. Whether the implant 100 is in storage or has been implanted into the target tissue 300, the protective coating can well protect the resonant circuit 110, thereby ensuring that its performance will not change. The protective coating can be a silicon coating, and of course it can also be other coatings, as long as the coating is harmless to the human body and has a better isolation effect.
[0024] In one embodiment, the resonant circuit 110 includes a first coil 111 and a capacitor 112 connected in series end to end, and the applicator 200 is used to apply an alternating magnetic field to the first coil 111 outside the target tissue 300.
[0025] Specifically, the first coil 111 is configured to induce an induced current in the first coil 111 after the applicator 200 applies an alternating magnetic field. The first coil 111 and the capacitor 112 are connected in series end to end, alternately storing and releasing energy, and simultaneously generating heat and releasing it into the target tissue 300. Preferably, the first coil 111 may include a plurality of windings, for example, it may be four windings. The length of the first coil 111 is between 2 mm and 8 mm, and the diameter is between 2 mm and 8 mm. Preferably, the length of the first coil 111 is 5 mm and the diameter is 5 mm.
[0026] Of course, in some other embodiments, the resonant circuit may further include elements such as resistors.
[0027] In one embodiment, the capacitance value of the capacitor 112 is between 20000 pF and 25000 pF, and the temperature characteristic of the capacitor 112 is less than one-fiftieth per million degrees Celsius change.
[0028] Specifically, the capacitor 112 is a micro capacitor, so as to minimize the volume of the entire resonant circuit 110 as much as possible to reduce the patient's perception. Its capacitance value is between 20000 pF and 25000 pF. For example, the capacitance value can be 20000 pF, 22000 pF or 25000 pF, etc. The present application does not limit its specific value. At the same time, the temperature characteristic of the capacitor 112 is less than one-fiftieth per million degrees Celsius change. For example, the temperature characteristic of the capacitor 112 can be one-sixtieth per million degrees Celsius change. The smaller temperature characteristic can reduce the expansion of the volume of the capacitor 112 in a heating environment, ensure the stability of the resonant circuit 110, and at the same time avoid excessive volume expansion from squeezing the tissue, which may cause discomfort to the patient.
[0029] In one application scenario, the resonance frequency of the resonant circuit 110 is modulated between 3 MHz and 5 MHz. For example, the resonance frequency is 3 MHz, 4 MHz or 5 MHz, and it has a good heating effect. Preferably, when the resonance frequency is 4 MHz, compared with the traditional radiofrequency ablation and microwave ablation that can only reach between 50 °C and 60 °C, the implant 100 of the present application can make the target tissue 300 reach a higher temperature (the average maximum temperature is 127.8 ± 39.3 °C) at a low output power.
[0030] In one embodiment, the material of the first coil 111 includes silver.
[0031] Specifically, the material of the first coil 111 is selected as silver. Compared with conventional materials such as iron or copper, on the one hand, it can reduce the resistance of the first coil 111, thereby reducing the loss of energy conversion from the alternating magnetic field applied by the applicator 200 into the energy in the first coil 111. On the other hand, silver material has a certain antibacterial effect, so even if the first coil 111 is accidentally damaged, the impact on the patient is relatively small.
[0032] In one embodiment, the applicator 200 includes a second coil 210 and a magnetic core 220, and the magnetic core 220 is disposed inside the second coil 210.
[0033] Specifically, the second coil 210 is used to generate an alternating magnetic field so that the first coil 111 in the resonant circuit 110 can induce an induced current. The magnetic core 220 is also disposed inside the second coil 210. Adding the magnetic core 220 can increase the magnetic flux density and the intensity of the alternating magnetic field, thereby enhancing the heating effect of the implant 100.
[0034] In one embodiment, the material of the second coil 210 includes copper, and the material of the magnetic core 220 includes a ferrite magnetic material. Of course, the materials of the second coil 210 and the magnetic core 220 can also be other conductive materials.
[0035] In one embodiment, the applicator 200 is further connected to a water cooling part (not shown in the figure).
[0036] Specifically, the water cooling part is used to prevent the temperature of the applicator 200 from rising, ensuring that the applicator 200 has a constant temperature and resistance, so as to ensure the stable performance of the applicator 200, and further ensure the stable heating effect of the implant 100. Preferably, the applicator 200 further includes a thermometer for monitoring the temperature of the applicator 200.
[0037] In one embodiment, the number of the applicators 200 is multiple, the number of the implants 100 is multiple, and the distance between two adjacent applicators 200 is between 15 cm and 25 cm.
[0038] Specifically, multiple applicators 200 can enhance the intensity of the alternating magnetic field, and multiple implants 100 can increase the heating range. Especially for some relatively large target tissues 300, sometimes it is necessary to increase the number of implants 100 to ensure that all positions of the target tissue 300 can be ablated. The distance between two adjacent applicators 200 usually affects the distribution and intensity of the magnetic field. A relatively large distance will affect the heating effect of the implant 100, while a relatively small distance will affect the intensity of the alternating magnetic field due to mutual inductance. Therefore, selecting an appropriate distance can greatly improve the heating effect. Further optimized according to experiments, a better effect can be obtained when the distance is between 15 cm and 25 cm. The distance can be 15 cm, 20 cm, 25 cm, etc. The present application does not limit the specific value thereof. Preferably, a distance sensor is further provided on the multiple applicators 200. When the distance is outside the preset range, the applicator 200 will issue a prompt, so as to facilitate the operator to confirm whether the placement distance of the applicator 200 is appropriate.
[0039] In an application scenario, when applying the solution of the present application to the ablation of the target tissue 300, the target tissue 300 can be divided into an internal ablation area A and an external area B. The internal area A is the core area of ablation, and the external area B is located on the periphery of the internal area A. The implant 100 is implanted into the internal area A. The internal area A is close to the implant 100, and the degree of cell change in the internal area A is significant, while the external area B is relatively far from the implant 100, and the degree of cell change in the external area B is relatively small. Further, there is a fibrotic area C outside the external area B. Fibrosis is a common phenomenon in the tissue repair process, usually caused by collagen deposition, indicating that the tissue is undergoing a healing process.
[0040] In an application scenario, when the applicator 200 applies an alternating magnetic field to the implant 100, the alternating magnetic field can be applied in an intermittent manner, which can avoid overheating in a short time, thereby avoiding damage to normal tissues. By applying the alternating magnetic field intermittently, it is possible to ensure sufficient heat while reducing local overheating, and to a certain extent expand the effect of the ablation range.
[0041] In an application scenario, before using the ablation device 10 of the present application for ablation, the implant 100 needs to be placed into the target tissue 300. In the traditional method, the implant 100 is placed into the target tissue 300 through an open surgery, which increases the pain of the patient and may also cause complications. Such a method is an invasive implantation technique. The implant 100 of the present application can adopt a non-invasive implantation technique. The specific solutions are as follows: First, in the percutaneous puncture method, under local anesthesia, the implant 100 is sent into the target tissue 300 through skin puncture, and the ultrasonic imaging technique is used to monitor the position and depth of the implant 100 in real time to ensure that the implant 100 is accurately placed within the target tissue 300. The multi-modal imaging technique can also be adopted, combining multi-modal imaging techniques such as CT (Computed Tomography) and MRI (Magnetic Resonance Imaging) to improve the accuracy of placing the implant 100. This method can reduce the pain of the patient and the risk of complications; Second, in the method assisted by a micro-robot, the micro-robot system is used to accurately place the implant 100 within the target tissue 300 through a minimally invasive incision. This method can not only reduce the pain of the patient and the risk of complications, but also improve the accuracy of the position where the implant 100 is placed within the target tissue 300.
[0042] Referring to Figure 2 , the present application also provides an ablation system 20, and the ablation system 20 includes the ablation device 10 in any of the above embodiments.
[0043] It should be noted that the detailed structure of the ablation device 10 in the ablation system 20 can refer to the embodiments of the above ablation device 10, which will not be elaborated here; since the above ablation device 10 is used in the ablation system 20 of the present application, therefore, the embodiments of the ablation system 20 of the present application include all the technical solutions of all the embodiments of the above ablation device 10, and the achieved technical effects are also exactly the same, which will not be elaborated here.
[0044] The above are only the embodiments of the present application, and do not limit the patent scope of the present application accordingly. Any equivalent structural or equivalent process transformation made by using the content of the specification and drawings of the present application, or directly or indirectly applied in other related technical fields, shall be equally included in the patent protection scope of the present application.
Claims
1. An ablation device, characterized in that: The ablation device comprises: at least one implant for implantation into a target tissue, the implant comprising a resonant circuit; At least one applicator is used to apply an alternating magnetic field to the resonant circuit outside the target tissue.
2. The ablation device according to claim 1, characterized in that: The surface of the implant is provided with a protective coating.
3. The ablation device according to claim 1, characterized in that: The resonant circuit includes a first coil and a capacitor connected in series end to end, and the applicator is used to apply an alternating magnetic field to the first coil outside the target tissue.
4. The ablation device according to claim 3, characterized in that: The capacitance value of the capacitor is between 20000 pF and 25000 pF, and the temperature characteristic of the capacitor varies by less than one-fiftieth per million degrees Celsius.
5. The ablation device according to claim 3, characterized in that: The material of the first coil includes silver.
6. The ablation device according to claim 1, characterized in that: The applicator includes a second coil and a magnetic core, wherein the magnetic core is inserted into the interior of the second coil.
7. The ablation device according to claim 6, characterized in that: The material of the second coil includes copper, and the material of the magnetic core includes ferrite magnetic material.
8. The ablation device according to claim 7, characterized in that: The applicator is also connected to a water cooling part.
9. The ablation device according to claim 1, characterized in that: The number of the applicators is multiple, the number of the implants is multiple, and the distance between two adjacent applicators is between 15 cm and 25 cm.
10. An ablation system, characterized in that: The ablation system comprises the ablation device according to any one of claims 1-9.