Sample target plate, sample target groove and mass spectrometer

Abstract

The invention discloses a sample target plate, which is used for bearing a sample, is configured to be matched with a sample target groove of a mass spectrometer to realize mass spectrum detection of the sample, and comprises a target point unit, the target point unit is arranged on the surface of the sample target plate, the target point unit comprises a plurality of target points which are sequentially arranged in the first direction, and the target points are used for bearing samples; after the sample target plate is mounted in the sample target groove, the target units of which at least part of targets are sequentially positioned at the detection position of the mass spectrometer are target target units along with the movement of the sample target groove; at least two groups of target spot units are arranged, the sample target plate can be matched with the sample target groove in at least two directions, and when the sample target plate is changed in different directions and is mounted in the sample target groove, different target spot units sequentially become target target spot units; the position precision in the target plate detection process can be improved, and meanwhile, compared with a sample target plate provided with only one group of target point units, the sample detection quantity on the same target plate can be improved.

Description

Technical Field

[0001] The present invention relates to the technical field of mass spectrometry detection, and particularly to a sample target plate, a sample target groove and a mass spectrometer. Background Art

[0002] A mass spectrometer, also known as a mass spectrograph, has a mass analyzer and an ion detector as its core, and is aimed at separating substances and detecting their compositions. Among them, an ion source is used to ionize sample molecules under high vacuum conditions, a mass analyzer is used to separate ions of different masses, and an ion detector is used to collect and amplify ion signals, providing data for a computer to draw a mass spectrum. A mass spectrometer has an ion source, a mass analyzer and an ion detector as its core. The ion source is a device that moves a sample sample back and forth, left and right under high vacuum conditions. The mass analyzer and the ion detector also require sample spotting on the detection channel.

[0003] Since a mass spectrometer separates and detects according to the principle that charged particles can be deflected in an electromagnetic field, and separates and detects according to the mass differences of atomic, molecular or molecular fragment of substances, ions are bombarded by energy and fly upward to the detector, and the flight channel does not need to move and change. Samples at different positions rely on the coordinate movement of a moving platform to achieve spotting at different positions.

[0004] Existing mass spectrometers all adopt an XY cross motion mechanism as the power source for the reciprocating motion of the target plate. The XY cross motion mechanism requires the cooperation of two sets of guiding mechanisms in two directions, which affects the moving accuracy of the target plate, and the two sets of guiding mechanisms occupy a large space, so that the volume of the vacuum chamber accommodating the motion mechanism is large, affecting the vacuum pumping efficiency. If a set of guiding mechanisms is used as the power source for the reciprocating motion of the target plate, the samples need to be arranged along the moving direction of the guiding mechanism, which cannot meet the requirements of some customers for the detection amount of samples on the same target plate.

[0005] Therefore, how to provide a sample target plate, a sample target groove and a mass spectrometer to at least partially solve the above drawbacks is a technical problem that those skilled in the art need to solve currently. Summary of the Invention

[0006] The purpose of the present invention is to provide a sample target plate, a sample target groove and a mass spectrometer, which can improve the detection amount of samples on the same target plate compared with a sample target plate provided with only a set of target point units.

[0007] To achieve the above purpose, the present invention provides a sample target plate, which is used to carry samples and is configured to be cooperatively installed with a sample target groove of a mass spectrometer to realize mass spectrometry detection of samples, and includes target point units;

[0008] The target unit is disposed on the surface of the sample target plate. The target unit includes a plurality of targets arranged in sequence along a first direction, and the targets are used to carry samples. When the sample target plate is installed in the sample target slot, the target unit that can make at least some of the targets be located at the detection position of the mass spectrometer in sequence as the sample target slot moves is the target target unit.

[0009] There are at least two groups of target units. The sample target plate can be installed in cooperation with the sample target slot in at least two orientations. When the sample target plate changes different orientations and is installed in the sample target slot, different target units become the target target units in sequence.

[0010] Preferably, there are two groups of target units, and the two groups of target units are arranged in parallel on the same surface of the sample target plate;

[0011] When the sample target plate is installed in the sample target slot, one of the target units is the target target unit;

[0012] When the sample target plate is horizontally rotated 180° and installed in the sample target slot, the other target unit is the target target unit.

[0013] Preferably, there are two groups of target units, and the two groups of target units are arranged in parallel on the opposite surfaces of the sample target plate;

[0014] When the sample target plate is installed in the sample target slot, one of the target units is the target target unit;

[0015] When the sample target plate is vertically flipped 180° and installed in the sample target slot, the other target unit is the target target unit.

[0016] Preferably, there are four groups of target units. Two of the target units are arranged in parallel on the first surface of the sample target plate; the other two groups of target units are arranged in parallel on the second surface of the sample target plate, and the first surface and the second surface are opposite surfaces;

[0017] When the first surface of the sample target plate is upward and installed in the sample target slot, one of the target units on the first surface is the target target unit;

[0018] When the first surface of the sample target plate is upward and horizontally rotated 180° and installed in the sample target slot, the other target unit on the first surface is the target target unit;

[0019] When the second surface of the sample target plate is upward and installed in the sample target slot, one of the target units on the second surface is the target target unit;

[0020] When the second surface of the sample target plate is upward and horizontally rotated 180° and installed in the sample target slot, the other target unit on the second surface is the target target unit.

[0021] Preferably, the sample target plate further includes a first identification mark for identifying different sample target plates and / or different target point units and / or different target points and / or sample information on different target points.

[0022] Preferably, a hydrophilic coating is applied inside the target point for sample enrichment.

[0023] Preferably, the sample target plate is provided with a first positioning hole and a second positioning hole. The first positioning hole can be assembled with the first positioning post on the sample target slot, and the second positioning hole can be assembled with the second positioning post on the sample target slot.

[0024] Preferably, the sample target plate includes a target holder and a target surface;

[0025] The target surface is a flat thin plate. The upper surface of the target surface is provided with target point units. The target holder is provided with a first plane for carrying the target surface. The sample target plate is cooperatively installed with the sample target slot of the mass spectrometer through the target holder.

[0026] Preferably, the target holder is provided with a chute for the target surface to slide into. One end of the chute in the sliding direction is provided with a sliding inlet, and the other end of the chute in the sliding direction is provided with a limiting portion for abutting against the corner of the target surface to limit the sliding distance of the target surface.

[0027] Preferably, the target holder is provided with a third positioning hole and a fourth positioning hole. The third positioning hole can be assembled with the third positioning post on the sample target slot, and the fourth positioning hole can be assembled with the fourth positioning post on the sample target slot.

[0028] Preferably, the upper surface of the target surface further includes a second identification mark for identifying different target surfaces and / or different target point units and / or different target points and / or sample information on different target points.

[0029] The present invention also provides a sample target slot arranged inside a mass spectrometer for carrying the above-mentioned sample target plate. The sample target slot is provided with at least two installation positions. Correspondingly, at least two groups of target point units are arranged on the sample target plate. When the sample target plate is installed at different installation positions inside the sample target slot, different target point units sequentially become the target target point units.

[0030] The present invention also provides a mass spectrometer including the above-mentioned sample target slot.

[0031] Preferably, the mass spectrometer further includes a motion mechanism capable of driving the sample target slot to move in a first direction.

[0032] Compared with the above background art, the sample target plate provided by the present invention is used to carry samples and is configured to be cooperatively installed with the sample target slot of a mass spectrometer to realize mass spectrometry detection of samples, and includes a target unit; the target unit is arranged on the surface of the sample target plate, and the target unit includes a plurality of targets arranged in sequence along a first direction, and the targets are used to carry samples; when the sample target plate is installed in the sample target slot, the target unit that can make at least some of the targets be located at the detection position of the mass spectrometer in sequence as the sample target slot moves is the target target unit; at least two groups of target units are provided, and the sample target plate can be cooperatively installed with the sample target slot in at least two orientations. When the sample target plate is installed in the sample target slot in different orientations, different target units become the target target units in sequence.

[0033] Specifically, by arranging at least two groups of target units on the sample target plate, and each of the at least two groups of target units includes a plurality of targets arranged in sequence along the first direction for carrying samples, the number of targets on the sample target plate is increased, thereby increasing the number of samples that can be carried at one time. The sample target plate can be cooperatively installed with the sample target slot in at least two orientations. After the sample target plate is placed in the sample target slot, through the one-way movement of the sample target slot, one group of target units is used as the target target unit, and the targets in this target unit are located at the detection position of the mass spectrometer in sequence for detection. After the detection of this group of target units is completed, the sample target plate is cooperatively installed with the sample target slot in another orientation, and then through the one-way movement of the sample target slot, another group of target units is used as the target target unit, and the targets in this target unit are located at the detection position of the mass spectrometer in sequence for detection. With such a setting, only the sample target slot moves in one direction, and in cooperation with the adjustment of the installation method of the sample target plate and the sample target slot, the detection of two or more groups of target units is completed, which can improve the position accuracy during the detection of the target plate and can increase the sample detection amount on the same target plate compared with the sample target plate with only one group of target units. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the drawings in the following description are only the embodiments of the present invention. For those of ordinary skill in the art, other drawings can be obtained according to the provided drawings without creative efforts.

[0035] Figure 1 Structural schematic diagram of the sample target plate or target surface provided by the embodiment of the present invention;

[0036] Figure 2 Structural schematic diagram of the target holder provided by the embodiment of the present invention;

[0037] Figure 3 For Figure 2 front view;

[0038] Figure 4 is the rear view of Figure 2 ;

[0039] Figure 5 is the sectional view along A-A in Figure 3 ;

[0040] Figure 6 is the schematic structural diagram of the target surface assembled to the target holder provided by the embodiment of the present invention;

[0041] Figure 7 is the top view of Figure 6 ;

[0042] Figure 8 is the exploded view of Figure 6 ;

[0043] Figure 9 is the schematic structural diagram of a sample target groove provided by the embodiment of the present invention;

[0044] Figure 10 is the sectional view of a sample target groove provided by the embodiment of the present invention;

[0045] Figure 11 is the schematic structural diagram when the target surface rotates 180° horizontally provided by the embodiment of the present invention;

[0046] Figure 12 is the schematic structural diagram when the target holder rotates 180° horizontally provided by the embodiment of the present invention;

[0047] Figure 13 is the schematic structural diagram of the target holder assembled to the sample target groove provided by the embodiment of the present invention;

[0048] Figure 14 is the schematic structural diagram of the sample target holder for sample injection provided by the embodiment of the present invention;

[0049] Figure 15 is the Figure 14 partial enlarged view of;

[0050] Figure 16 is the schematic structural diagram of another view of the sample target holder for sample injection provided by the embodiment of the present invention;

[0051] Figure 17 is the schematic structural diagram of the movement direction of the movement mechanism provided by the embodiment of the present invention;

[0052] Figure 18 is the schematic structural diagram of the A group of target point units in the sample target plate being the target target point units provided by the embodiment of the present invention;

[0053] Figure 19Schematic diagram of the structure where the target point unit of group B is the target target unit in the sample target board provided by the embodiment of the present invention;

[0054] Figure 20 Schematic diagram of the structure where the target point unit of group D is the target target unit in the sample target board provided by the embodiment of the present invention;

[0055] Figure 21 Schematic diagram of the structure where the target point unit of group C is the target target unit in the sample target board provided by the embodiment of the present invention;

[0056] Figure 22 Schematic diagram of the structure of another sample target groove provided by the embodiment of the present invention;

[0057] Figure 23 Schematic diagram of the structure where the target point unit of group B is the target target unit on the target surface provided by the embodiment of the present invention;

[0058] Figure 24 Schematic diagram of the structure where the target point unit of group A is the target target unit on the target surface provided by the embodiment of the present invention.

[0059] Wherein:

[0060] 10 - Sample target board;

[0061] 100 - Target surface, 111 - Target point, 112 - Central axis, 113 - Column number identification code, 114 - Position identification code, 115 - Corner, 116 - Column number identification label, 117 - Barcode area, 118 - Target board number, 119 - First positioning hole, 120 - Second positioning hole;

[0062] 200 - Target holder, 210 - First plane, 211 - Third positioning hole, 212 - Fourth positioning hole, 220 - Guide, 221 - First end, 222 - Second end, 223 - Limiting part, 224 - Second plane, 225 - Second chamfer, 230 - First notch, 240 - Second notch, 250 - First magnetic part, 260 - Protective sheet, 270 - Pick - and - place position, 280 - Positioning groove;

[0063] 300 - Sample target groove, 310 - Second groove, 311 - First protrusion, 312 - Third positioning post, 313 - Fourth positioning post, 320 - Pick - and - place accommodation groove, 330 - Second magnetic part, 340 - Avoidance space;

[0064] 400 - Cover plate;

[0065] 500 - Motion mechanism. Detailed implementation manners

[0066] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0067] In order to enable those skilled in the art of this technology to better understand the solution of the present invention, the present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0068] In the description of the present invention, it should be understood that the orientation or positional relationship indicated by terms such as "upper", "lower", "top", "bottom", etc. is based on the orientation or positional relationship shown in the accompanying drawings. It is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the indicated position or element must have a specific orientation, be constructed and operated in a specific orientation, and thus cannot be construed as a limitation of the present invention.

[0069] The object of the present invention is to provide a sample target plate 10, a sample target groove 300, and a mass spectrometer, which can improve the position accuracy during the target plate detection process, and at the same time can increase the sample detection amount on the same target plate compared with the sample target plate 10 provided with only one set of target point units.

[0070] It should be noted that in this embodiment, the direction of X in the accompanying drawings is defined as the first direction, and the direction of Y is defined as the second direction, and the first direction and the second direction are perpendicular to each other.

[0071] Please refer to Figures 1 to 24 , to achieve the above object, the present invention provides a sample target plate 10, which is used to carry samples and is configured to be cooperatively installed with the sample target groove 300 of the mass spectrometer to realize the mass spectrometry detection of the samples, and includes target point units; the target point units are arranged on the surface of the sample target plate 10, and the target point units include a plurality of target points 111 arranged in sequence along the first direction, that is, the central axis 112 of the same target point unit extends along the first direction, and the target points 111 are used to carry samples; when the sample target plate 10 is installed in the sample target groove 300, at least some of the target points 111 (preferably all the target points 111 in this embodiment) can be sequentially located at the detection position of the mass spectrometer as the target target unit with the movement of the sample target groove 300, that is, the target point unit placed at the detection position is the target target unit. The detection position can be referred to the M mark in the attached Figure 18 to the attached Figure 23 at the M mark in, and the target point unit corresponding to the M mark is the target target unit; there are at least two groups of target point units, and the sample target plate 10 can be cooperatively installed with the sample target groove 300 in at least two orientations. When the sample target plate 10 changes different orientations and is installed in the sample target groove 300, different target point units become the target target units in turn.

[0072] Taking the target units being set in two groups, namely the first group of target units and the second group of target units as an example, when the sample target plate 10 is installed in cooperation with the sample target slot 300 in one orientation, it can ensure that the first group of target units are located at a preset position within the sample target slot 300 (the preset position can be the position where the target target units are located). Driven by the sample target slot 300, the detection of the samples on each target 111 in the first group of target units is completed. Then, the orientation of the sample target plate 10 relative to the sample target slot 300 is adjusted so that the first group of target units move out of the preset position and the second group of target units are located at the preset position within the sample target slot 300. Driven by the sample target slot 300, the detection of the samples on each target 111 in the second group of target units is completed. Among them, the change in the orientation of the sample target plate 10 relative to the sample target slot 300 includes but is not limited to the horizontal rotation, horizontal flipping, horizontal translation, flipping along the axis of the bottom surface of the sample target plate 10, and the combination of the four orientation change methods.

[0073] By setting two groups of target units on the sample target plate 10, and both of these two groups of target units include a number of targets 111 arranged in sequence along the first direction for carrying samples, the number of targets 111 on the sample target plate 10 is increased, thereby increasing the number of samples that can be carried at one time (in this application, the number of samples that can be carried at one time refers to the number of samples that the sample target plate 10 can carry at one time, which is basically equivalent to the number of targets 111 on the sample target plate 10). The sample target plate 10 can be installed in cooperation with the sample target slot 300 in at least two orientations. After placing the sample target plate 10 in the sample target slot 300, through the one-way movement of the sample target slot 300, one group of target units is taken as the target target units, and the targets 111 in this target unit are sequentially located at the mass spectrometer detection position for detection. After the detection of this group of target units is completed, the sample target plate 10 is installed in cooperation with the sample target slot 300 in another orientation. Then, through the one-way movement of the sample target slot 300, the other group of target units is taken as the target target units, and the targets 111 in this target unit are sequentially located at the mass spectrometer detection position for detection. With such a setting, only the sample target slot 300 moves in one direction, and in cooperation with the adjustment of the installation method of the sample target plate 10 and the sample target slot 300, the detection of two or more groups of target units is completed, which can improve the position accuracy during the target plate detection process. At the same time, compared with the sample target plate 10 with only one group of target units, the sample detection amount on the same target plate can be increased.

[0074] In one embodiment, two sets of target units are provided, and the two sets of target units are arranged in parallel on the same surface of the sample target plate 10; when the sample target plate 10 is installed in the sample target slot 300, one set of target units is the target target unit; when the sample target plate 10 is horizontally rotated 180° and installed in the sample target slot 300, the other set of target units is the target target unit; the two sets of target units can be arranged centrally symmetrically on the same surface of the sample target plate 10. After the detection of one set of target units is completed, by horizontally rotating the sample target plate 10 by 180°, the other set of target units is used as the target target unit for detection. The operation is convenient and easy to master, reducing the user's learning cost and improving the user experience.

[0075] In one embodiment, two sets of target units are provided, and the two sets of target units are arranged in parallel on the opposite surfaces of the sample target plate 10; when the sample target plate 10 is installed in the sample target slot 300, one set of target units is the target target unit; when the sample target plate 10 is vertically flipped 180° and installed in the sample target slot 300, the other set of target units is the target target unit, where the vertical flip of 180° can be performed with the axis of the bottom surface of the sample target plate 10 as the rotation axis. With such a setting, both opposite surfaces (which can be the top surface and the bottom surface) of the sample target plate 10 can be well utilized. Since the two sets of target units are respectively arranged on the opposite surfaces of the sample target plate 10, no matter whether the sample target plate 10 is placed with the top surface facing up or the bottom surface facing up, there will be one set of target units as the target target unit, thus making full use of the two surfaces of the sample target plate 10. The sample detection can be performed on any surface of the sample target plate 10 according to actual needs, improving the detection efficiency.

[0076] In one embodiment, four sets of target units are provided, where two sets of target units are arranged in parallel on the first surface of the sample target plate 10; the other two sets of target units are arranged in parallel on the second surface of the sample target plate 10, and the first surface and the second surface are opposite surfaces; when the sample target plate 10 is installed in the sample target slot 300 with the first surface facing up, one set of target units on the first surface is the target target unit; when the sample target plate 10 is installed in the sample target slot 300 with the first surface facing up and horizontally rotated 180°, the other set of target units on the first surface is the target target unit; when the sample target plate 10 is installed in the sample target slot 300 with the second surface facing up, one set of target units on the second surface is the target target unit; when the sample target plate 10 is installed in the sample target slot 300 with the second surface facing up and horizontally rotated 180°, the other set of target units on the second surface is the target target unit.

[0077] Specifically, the detection of two groups of target units on the first side is carried out first, with the first side facing up. After the detection of one group of target units on the first side is completed, the sample target plate 10 is horizontally rotated 180°, so that the other group of target units on the first side becomes the target target units for detection. Then, the sample target plate 10 is vertically flipped 180° and installed in the sample target slot 300, with the second side facing up, to carry out the detection of two groups of target units on the second side. After the detection of one group of target units on the second side is completed, the sample target plate 10 is horizontally rotated 180°, so that the other group of target units on the second side becomes the target target units for detection. In this way, the sequential detection of four groups of target units can be completed through one sample target plate 10. Compared with only two groups of target units being set on the same sample target plate 10, the sample target plate 10 with four groups of target units can increase the number of target points 111 on the sample target plate 10, thereby increasing the number of samples that can be carried at one time. In addition, according to actual needs, the target units can also be set to three groups, where two groups of target units can be set on one of the first side and the second side, and the other group of target units can be set on the other of the first side and the second side. Details are not described here, as long as the above purpose can be achieved.

[0078] In one embodiment, the sample target plate 10 further includes a first identification mark, which is used for identifying different sample target plates 10 and / or different target units and / or different target points 111 and / or sample information on different target points 111. Among them, the first identification mark includes a column number identification code 113, a position identification code 114, a column number identification label 116, a bar code area 117, and a target plate number 118. The target plate number 118 and the bar code area 117 are respectively used for device identification and scanning to distinguish different sample target plates 10; the column number identification label 116 corresponds to each target unit one by one and is used for marking the column number of the target unit, that is, for distinguishing different target units on the same sample target plate 10. For example, groups of four target units can be respectively marked with A, B, C, and D; the column number identification code 113 is located at one end of the target unit in the first direction and is used to assist in distinguishing different target units on the same sample target plate 10; the position identification code 114 is set at one end of the target point 111 in the first direction and is used to distinguish different target points 111 on the same target unit, so that information on different or the same samples set on different target points 111 can be identified; after the camera identifies the column number identification code 113, it automatically samples and records the column number. The position identification codes 114 corresponding to the target points 111 in each column can all start from 1, for example, 1, 2, 3... 12. The position identification codes 114 corresponding to the target points 111 in each column can also be set differently. For example, the position identification codes 114 of each target point on the first group of target units are 1, 2, 3... 12 in sequence, and the position identification codes 114 of each target point on the second group of target units are set to 13, 14, 15... 24 in sequence, etc. The camera can perform double authentication of the target point 111 positions to ensure the accuracy of sample recording and collection.

[0079] In one embodiment, the inside of the target point 111 is coated with a hydrophilic coating, which is used for sample enrichment. Samples can be freely spotted in the enrichment area of the target point 111, enabling more flexible selection of the spotting position and spotting volume. At the same time, it can ensure the uniform distribution of the samples on the target point 111, thereby improving the accuracy and reliability of subsequent detections.

[0080] In one embodiment, the sample target plate 10 is provided with a first positioning hole 119 and a second positioning hole 120. The first positioning hole 119 can be assembled with the first positioning post on the sample target groove 300, and the second positioning hole 120 can be assembled with the second positioning post on the sample target groove 300. Specifically, a plurality of first positioning holes 119 and a plurality of second positioning holes 120 can be provided. One first positioning hole 119 and one second positioning hole 120 can be used as a set of positioning structures for positioning and assembling with the sample target groove 300. For example, when a set of positioning structures is assembled with the first positioning post and the second positioning post on the sample target groove 300, a set of target point units on the sample target plate 10 can be used as the target target point units for detection. Then, by removing this set of positioning structures and assembling another set of positioning structures with the first positioning post and the second positioning post on the sample target groove 300, another set of target point units can be used as the target target point units for detection. The cross-sectional shapes of the first positioning hole 119 and the second positioning hole 120, as well as the cross-sectional shapes of the first positioning post and the second positioning post, can be set according to actual needs, as long as the first positioning post and the first positioning hole 119 are adapted to each other, and the second positioning post and the second positioning hole 120 are adapted to each other.

[0081] Furthermore, the first positioning hole 119 and the second positioning hole 120 of the same set of positioning structures can be arranged at intervals in the first direction. When there are two sets of positioning structures, the two first positioning holes 119 can be arranged in central symmetry, and the two second positioning holes 120 can be arranged in central symmetry. Also, the two first positioning holes 119 can be arranged at intervals in the direction of the arrangement of the target point units, and the two second positioning holes 120 can be arranged at intervals in the direction of the arrangement of the target point units. In a feasible solution, both the first positioning post and the second positioning post are in the shape of a cone. One of the first positioning hole 119 and the second positioning hole 120 is a circular through hole adapted to the cone, and the other is an elliptical through hole adapted to the cone. Axial positioning of the sample target plate 10 is carried out through the circular through hole, and further restriction of the planar movement of the sample target plate 10 is achieved through the elliptical through hole. At the same time, the elliptical through hole facilitates the matching process between the sample target plate 10 and the sample target groove 300.

[0082] In another embodiment, the sample target plate 10 includes a target holder 200 and a target surface 100; the target surface 100 is a flat thin plate, which can be made of ultra-thin silicon steel, ceramic, plastic, etc. The upper surface of the target surface 100 is provided with target point units. The target holder 200 is provided with a first plane 210, and the first plane 210 is used to carry the target surface 100. The sample target plate 10 is cooperatively installed with the sample target slot 300 of the mass spectrometer through the target holder 200; the sample target plate 10 can be cooperatively installed with the sample target slot 300 in at least two orientations, including one or a combination of the following schemes: the target surface 100 is cooperatively installed with the target holder 200 in at least two orientations; the target holder 200 is cooperatively installed with the sample target slot 300 in at least two orientations. Among them, the target surface 100 is cooperatively installed with the target holder 200 in at least two orientations, including but not limited to the rotation and translation of the target surface 100 relative to the target holder 200. The target holder 200 is cooperatively installed with the sample target slot 300 in at least two orientations, also including but not limited to the rotation and translation of the target holder 200 relative to the sample target slot 300.

[0083] In one of the embodiments, two sets of target point units are provided, and the two sets of target point units are arranged in parallel on the upper surface of the target surface 100; when the sample target plate 10 is installed in the sample target slot 300, one set of target point units is the target target point unit; when the target holder 200 is horizontally rotated 180° and installed in the sample target slot 300, or the target surface 100 is horizontally rotated 180° and installed in the target holder 200, the other set of target point units is the target target point unit; that is, the detection of one set of target point units is completed by installing the sample target plate 10 including the target holder 200 and the target surface 100 in the sample target slot 300. After that, the detection of the other set of target point units is completed by horizontally rotating the target holder 200 by 180° or horizontally rotating the target surface 100 by 180° and then installing the entire sample target plate 10 in the sample target slot 300.

[0084] Furthermore, as Figures 18 to 21 shown, four sets of target point units are provided, and the four sets of target point units are arranged in parallel on the upper surface of the target surface 100; as Figure 18 shown, when the sample target plate 10 is installed in the sample target slot 300, the A group of target point units is the target target point unit; as Figure 19 shown, when the target holder 200 remains stationary and the target surface 100 is horizontally rotated 180° and installed in the target holder 200, the B group of target point units is the target target point unit; as Figure 20 shown, on the basis of Figure 18 , when the target surface 100 is horizontally rotated 180° along with the target holder 200 and installed in the sample target slot 300, the D group of target point units is the target target point unit; as Figure 21 shown, on the basis of Figure 18On the basis of this, when the target holder 200 drives the target surface 100 to rotate horizontally by 180° and is installed into the sample target groove 300, and when the target surface 100 rotates horizontally by 180° and is installed into the target holder 200, the C group of target point units are the target target point units. Among them, there is no actual order requirement for the detection of the four groups of target point units. For example, the target surface 100 can be rotated horizontally by 180° and then installed into the target holder 200 again, and the target holder 200 remains stationary relative to the sample target groove 300, and the second group of target point units are used as the target target point units for detection. Then, by keeping the target surface 100 stationary and rotating the target holder 200 by 180° and then cooperating with another position of the sample target groove 300, the detection of the third group of target point units is realized. After that, the target holder 200 remains stationary and the target surface 100 rotates relative to the target holder 200 by 180°, and the detection of the fourth group of target point units is realized.

[0085] In one embodiment, the target holder 200 is provided with a chute for the target surface 100 to slide into. One end of the chute in the sliding direction is provided with a sliding inlet, and the other end of the chute in the sliding direction is provided with a limiting portion 223. The limiting portion 223 is used to abut against the corner portion 115 of the target surface 100 to limit the sliding distance of the target surface 100. The target holder 200 is provided with a first plane 210 and two parallel guiding members 220 spaced apart on the first plane 210. The ends of the two guiding members 220 facing away from the first plane 210 extend towards each other to form a first guiding groove. The space between the two first guiding grooves constitutes the above-mentioned chute. The first guiding groove can be slidably engaged with both sides of the target surface 100 in the second direction, so that the target surface 100 can slide onto the first plane 210, avoiding the problem of uneven height of the target plate that is likely to occur when placing the target plate onto the target holder 200 from top to bottom. Both of the two guiding members 220 include a first end 221 and a second end 222. A sliding inlet for the target surface 100 to slide onto the first plane 210 is formed between the two first ends 221. A limiting portion 223 is provided on the side where the two second ends 222 face each other. The limiting portion 223 can abut against the corner portion 115 on the target surface 100 to limit the sliding distance of the target surface 100. When the two corner portions 115 at one end of the target surface 100 slide along the first guiding groove and abut against the limiting portion 223, the target surface 100 moves into place. After the detection of the first group of target point units on the target surface 100 is completed, the target surface 100 is slid out along the first guiding groove, and then the other end of the target surface 100 is placed at the sliding inlet, and then it continues to slide along the first guiding groove until the two corner portions 115 at this end abut against the limiting portion 223, and the target surface 100 moves into place again.

[0086] When only two groups of target point units are provided on the target surface 100, the detection of the two groups of target point units can be realized by rotating the target holder 200 horizontally by 180°. The corner portions 115 on the target surface 100 can be set differently. For example, the four corner portions 115 of the target surface 100 are set as two large chamfers and two small chamfers, and only the two large chamfers can abut against the limiting portion 223 to prevent the staff from installing it in the wrong way.

[0087] Further, the target holder 200 further includes a first notch 230 and a second notch 240. The first notch 230 is located between two first ends 221; the second notch 240 is provided at one end of the target holder 200 facing away from the first notch 230; the first notch 230 and the second notch 240 can make a part of the target surface 100 suspended, for the process of the target surface 100 sliding into and out of the first guiding groove. During the sliding-in process, through the second notch 240, an avoidance space for the hand-held target surface 100 to slide into the first guiding groove is formed, facilitating the pushing of the target surface 100 until the corner 115 abuts against the limiting portion 223; during the sliding-out process, through the second notch 240, the staff can hold both sides of the target surface 100 in the second direction to clamp and move the target surface 100 outwards. When the movement is blocked, the staff can push the target surface 100 at the first notch 230 to facilitate the sliding of the target surface 100 out towards the end away from the first notch 230.

[0088] Second chamfers 225 are provided at the first ends 221 of the two guiding members 220, so that the sliding-in port has a flared structure. Through the setting of the second chamfers 225 and the corners 115, it is convenient for the two corners 115 at one end of the target surface 100 to horizontally or vertically fall into the sliding-in port, increasing the ways of placing the target surface 100 at the sliding-in port and avoiding the collision between the end of the target surface 100 and the side wall of the target holder 200 and the guiding members 220. The target holder 200 is further provided with a first groove, and a first magnetic member 250 capable of magnetically attracting the target surface 100 is arranged in the first groove, so that the target surface 100 fits on the first plane 210. The first magnetic member 250 and the protective sheet 260 for closing the first groove can be arranged at the top and / or bottom of the target holder 200. The first magnetic member 250 can be a neodymium iron boron magnet, etc., and the protective sheet 260 can be a silicon wafer, as long as the above purposes can be achieved. The first magnetic member 250 can provide a magnetic guiding force for the target surface 100 to be placed on the first plane 210. At the same time, after the corners 115 of the target surface 100 slide into the position of the limiting portion 223 of the target holder 200, the first magnetic member 250 can keep the target surface 100 from sliding out within the target holder 200.

[0089] In some embodiments, the two sides of the target holder 200 are partially concave to form a pick-up and placement position 270, facilitating the transfer of the target holder 200 by the staff. The tops of the two guiding members 220 both have a second plane 224, and the second plane 224 is parallel to the first plane 210, for stacking the target holders 200, and at the same time, it can avoid the target surface 100 placed on the first plane 210 from being squeezed.

[0090] In one embodiment, the target holder 200 is provided with a third positioning hole 211 and a fourth positioning hole 212. The third positioning hole 211 can be assembled with the third positioning post 312 on the sample target groove 300, and the fourth positioning hole 212 can be assembled with the fourth positioning post 313 on the sample target groove 300. The number of the third positioning holes 211 and the fourth positioning holes 212 can be set according to actual needs. Taking two groups of the third positioning holes 211 and two groups of the fourth positioning holes 212 as an example, the third positioning holes 211 and the fourth positioning holes 212 are formed on the first plane 210 and penetrate through the target holder 200. One third positioning hole 211 and one fourth positioning hole 212 form a set of positioning structures. For example, when a set of positioning structures is assembled with the third positioning post 312 and the fourth positioning post 313 on the sample target groove 300, a set of target point units in the target surface 100 placed on the target holder 200 can be used as target target point units for detection. Then, by removing this set of positioning structures and assembling another set of positioning structures with the third positioning post 312 and the fourth positioning post 313 on the sample target groove 300, another set of target point units can be used as target target point units for detection. The cross-sectional shapes of the third positioning hole 211 and the fourth positioning hole 212, as well as the cross-sectional shapes of the third positioning post 312 and the fourth positioning post 313, can be set according to actual needs, as long as the third positioning post 312 and the third positioning hole 211 are adapted to each other, and the fourth positioning post 313 and the fourth positioning hole 212 are adapted to each other.

[0091] Further, the third positioning hole 211 and the fourth positioning hole 212 of the same set of positioning structures can be arranged at intervals along the first direction. When there are two sets of positioning structures, the two third positioning holes 211 can be arranged in central symmetry, and the two fourth positioning holes 212 can be arranged in central symmetry; alternatively, the two third positioning holes 211 can be arranged at intervals along the arrangement direction of the target point units, and the two fourth positioning holes 212 can be arranged at intervals along the arrangement direction of the target point units. In a feasible solution, both the third positioning post 312 and the fourth positioning post 313 are in the shape of a cone. One of the third positioning hole 211 and the fourth positioning hole 212 is a circular through hole adapted to the cone, and the other is an elliptical through hole adapted to the cone. Axial positioning of the sample target plate 10 is performed through the circular through hole, and further restriction of the plane movement of the sample target plate 10 is achieved through the elliptical through hole. At the same time, the elliptical through hole facilitates the matching process between the sample target plate 10 and the sample target groove 300.

[0092] Among them, the upper surface of the target surface 100 further includes a second identification mark, which is used for the identification of different target surfaces 100 and / or different target point units and / or different target points 111 and / or sample information on different target points 111. Among them, the second identification mark includes a column number identification code 113, a position identification code 114, a column number identification label 116, a bar code area 117, and a target plate number 118. The target plate number 118 and the bar code area 117 are respectively used for the identification and scanning of the device to distinguish different target surfaces 100; the column number identification label 116 corresponds to the target point unit one by one and is used for the column number marking of the target point unit, that is, for distinguishing different target point units on the same target surface 100; the column number identification code 113 is located at one end of the target point unit in the first direction and is used to assist in distinguishing different target point units on the same target surface 100; the position identification code 114 is set at one end of the target point 111 in the first direction and is used for the distinction of different target points 111 on the same target point unit, so as to identify the information of different or the same samples set on different target points 111. After the camera identifies the column number identification code 113, it automatically samples and records the column number. The position identification codes 114 corresponding to the target points 111 in each column can all start from 1, for example, 1, 2, 3... 12. The position identification codes 114 corresponding to the target points 111 in each column can also be set differently. For example, the position identification codes 114 of each target point unit in the first group are successively 1, 2, 3... 12, and the position identification codes 114 of each target point unit in the second group are successively set to 13, 14, 15... 24, etc. The camera can perform double authentication of the target point 111 positions to ensure the accuracy of sample recording and collection.

[0093] The present application further provides a sample target slot 300, which is arranged in the mass spectrometer and is used to carry the above-mentioned sample target plate 10. The sample target slot 300 is provided with at least two installation positions. Correspondingly, the sample target plate 10 is provided with at least two groups of target point units. When the sample target plate 10 is installed in different installation positions in the sample target slot 300, different target point units become the target target point units in turn. The two installation positions can partially overlap, so that the sample target plate 10 or the target holder 200 can be translated or rotated or both translated and rotated and then placed at different positions on the sample target slot 300, so that different target point units are used as the target target point units for subsequent detection.

[0094] Taking the example that the sample target slot 300 is provided with two installation positions, and four groups of target point units (Group A target point unit, Group B target point unit, Group C target point unit, Group D target point unit) are provided on one side of the sample target plate 10 or the target surface 100. First, place the sample target plate 10 or the target surface 100 with the target holder 200 on the first installation position of the sample target slot 300, and use the Group A target point unit at the M position as the target target unit for subsequent detection. Then, rotate the sample target plate 10 horizontally by 180° and continue to place it on the first installation position so that the Group B target point unit that is centrosymmetric with the Group A target point unit is at the M position as the target target unit for subsequent detection. Then, translate the sample target plate 10 to the second installation position of the sample target slot 300 so that the Group D target point unit is at the M position as the target target unit for subsequent detection. Finally, rotate the sample target plate 10 horizontally by 180° and continue to place it in the second installation position of the sample target slot 300 so that the Group C target point unit that is centrosymmetric with the Group D target point unit is at the M position as the target target unit for subsequent detection. In this way, the detection of the four groups of target point units is completed in sequence.

[0095] When the sample target slot 300 is provided with two installation positions, and the sample target plate 10 or the target surface 100 is only provided with two groups of target point units (Group A target point unit, Group B target point unit), it can be achieved by placing the sample target plate 10 or the target surface 100 with the target holder 200 on the first installation position of the sample target slot 300, using the Group A target point unit at the M position as the target target unit for subsequent detection, and then translating the sample target plate 10 or the target surface 100 with the target holder 200 to the second installation position of the sample target slot 300, using the Group B target point unit at the M position as the target target unit for subsequent detection.

[0096] In addition, the sample target groove 300 is provided with a second groove 310 and pick-and-place accommodation grooves 320 extending on both sides of the second groove 310. The pick-and-place accommodation grooves 320 are used for picking and placing the target holder 200 in the integrated sample target plate 10 or the split sample target plate 10. The bottom surface of the second groove 310 is provided with a first protrusion 311, the above-mentioned first positioning post and second positioning post (or the above-mentioned third positioning post 312 and fourth positioning post 313). The bottom of the sample target plate 10 or the target holder 200 is provided with a third plane, and a number of positioning grooves 280 with the same depth are opened on the third plane. The first protrusion 311 is adapted to and corresponds to the positioning grooves 280 one by one. The top of the first protrusion 311 is a planar structure, and all the planar structures are coplanar, which is convenient for the stable placement of the sample target plate 10 or the target holder 200. At the same time, a gap can be formed between the third plane and the bottom surface of the second groove 310, avoiding the situation where the third plane cannot fit after accidentally contacting foreign objects with the second groove 310. The bottom surface of the second groove 310 is further provided with a third groove, and a second magnetic member 330 is arranged in the third groove. The second magnetic member 330 can magnetically attract the first magnetic member 250 in the sample target plate 10 or the target holder 200 to limit the axial separation of the sample target plate 10 or the target holder 200 from the planar structure, and improve the stability of the sample target plate 10 or the target holder 200 after being placed in the second groove 310.

[0097] The present application further provides a mass spectrometer, including the above-mentioned sample target groove 300, and also having all the beneficial effects of the above-mentioned sample target groove 300. In addition, the mass spectrometer further includes a motion mechanism 500 capable of driving the sample target groove 300 to move along a first direction. Under the drive of the motion mechanism 500, the sample target groove 300 disengages from the cover plate 400 and enters the vacuum chamber for sample identification. The sample target groove 300 is provided with an in-target avoidance space 340 at the in-let end, which can avoid the motion interference with the cover plate 400 during the in-target and out-target motion process and smoothly complete the in-let motion.

[0098] It should be noted that in this specification, relational terms such as first and second are only used to distinguish one entity from several other entities, and do not necessarily require or imply any actual relationship or order between these entities.

[0099] In this specification, the various embodiments are described in a progressive manner. Each embodiment focuses on the differences from other embodiments. The same or similar parts among the various embodiments can be referred to each other.

[0100] Specific examples are used in this article to elaborate on the principles and implementation manners of the present invention. The descriptions of the above embodiments are only used to help understand the method and its core idea of the present invention. It should be pointed out that for those of ordinary skill in the art in this technical field, without departing from the principle of the present invention, several improvements and modifications can be made to the present invention, and these improvements and modifications also fall within the protection scope of the present invention.

Claims

1. A sample target plate, which is used to carry a sample and is configured to be installed in cooperation with a sample target slot of a mass spectrometer to achieve mass spectrometry detection of the sample, characterized in that: Including target unit; The target point unit is arranged on the surface of the sample target plate, and the target point unit includes a plurality of target points arranged in sequence along a first direction, and the target points are used to carry the sample; when the sample target plate is mounted to the sample target slot, the target point unit that can realize at least part of the target points being located in sequence at the mass spectrometer detection position as the sample target slot moves is the target target point unit; The target point units are provided with at least two groups, and the sample target plate can be installed in cooperation with the sample target slot in at least two orientations. When the sample target plate changes to different orientations and is installed in the sample target slot, different target point units become the target target point units in turn.

2. The sample target plate according to claim 1, characterized in that: The target point units are provided in two groups, and the two groups of target point units are arranged in parallel on the same surface of the sample target plate; When the sample target plate is mounted to the sample target slot, one group of the target point units is a target target point unit; When the sample target plate is horizontally rotated 180° and installed in the sample target groove, another group of target point units are target target point units.

3. The sample target plate according to claim 1, characterized in that: The target point units are provided in two groups, and the two groups of target point units are arranged in parallel on opposite sides of the sample target plate; When the sample target plate is mounted to the sample target slot, one group of the target point units is a target target point unit; When the sample target plate is vertically flipped 180° and installed in the sample target groove, another group of target point units are target target point units.

4. The sample target plate according to claim 1, characterized in that: The target point units are arranged in four groups, wherein two groups of the target point units are arranged in parallel on the first surface of the sample target plate; the other two groups of the target point units are arranged in parallel on the second surface of the sample target plate, and the first surface and the second surface are opposite surfaces; When the first surface of the sample target plate is mounted upward to the sample target slot, one group of the target point units on the first surface is a target target point unit; When the first surface of the sample target plate is upward and horizontally rotated 180° and mounted to the sample target groove, another group of target point units on the first surface are target target point units; When the second surface of the sample target plate is mounted upward to the sample target groove, one group of the target point units on the second surface is a target target point unit; When the second surface of the sample target plate is upward and horizontally rotated 180° and mounted to the sample target groove, another group of target point units on the second surface are target target point units.

5. The sample target plate according to claim 1, characterized in that: The sample target plate further comprises a first identification mark, and the first identification mark is used for identifying different sample target plates and / or different target point units and / or different target points and / or sample information on different target points.

6. The sample target plate according to claim 1, characterized in that: The target spot is coated with a hydrophilic coating, and the hydrophilic coating is used for enriching the sample.

7. The sample target plate according to claim 1, characterized in that: The sample target plate is provided with a first positioning hole and a second positioning hole. The first positioning hole can be assembled with a first positioning column on the sample target groove, and the second positioning hole can be assembled with a second positioning column on the sample target groove.

8. The sample target plate according to claim 1 or 2, characterized in that: The sample target plate comprises a target holder and a target surface; The target surface is a flat thin plate, the upper surface of which is provided with the target point unit, the target holder is provided with a first plane, the first plane is used to support the target surface, and the sample target plate is installed in cooperation with the sample target slot of the mass spectrometer through the target holder.

9. The sample target plate according to claim 8, characterized in that: The target holder is provided with a sliding groove for the target surface to slide into, a sliding entrance is provided at one end of the sliding groove in the sliding direction, and a limiting portion is provided at the other end of the sliding groove in the sliding direction, and the limiting portion is used to abut against the corner of the target surface to limit the sliding distance of the target surface.

10. The sample target plate according to claim 8, characterized in that: The target holder is provided with a third positioning hole and a fourth positioning hole. The third positioning hole can be assembled with the third positioning column on the sample target groove, and the fourth positioning hole can be assembled with the fourth positioning column on the sample target groove.

11. The sample target plate according to claim 8, characterized in that: The upper surface of the target surface also includes a second identification mark, which is used to identify different target surfaces and / or different target point units and / or different target points and / or sample information on different target points.

12. A sample target slot, which is arranged in a mass spectrometer and is used to carry the sample target plate according to any one of claims 1 to 11, characterized in that: The sample target slot is provided with at least two installation positions, and correspondingly, the sample target plate is provided with at least two groups of target point units. When the sample target plate is installed to different installation positions in the sample target slot, different target point units become the target target point units in turn.

13. A mass spectrometer, characterized in that: Comprising the sample target groove as described in claim 12.

14. The mass spectrometer according to claim 13, characterized in that It also includes a motion mechanism capable of driving the sample target groove to move along a first direction.

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