Medical anti-infection breathable disposable glove

Abstract

The invention provides a medical anti-infection breathable disposable glove. The medical anti-infection breathable disposable glove comprises an outer layer, a middle layer and an inner layer which are sequentially compounded into a gradient composite film from outside to inside, the outer layer is a 0.02 mm silver-containing zeolite coating, the outer surface of the outer layer is provided with a nanocone array with the height of 5 microns and the interval of 10 microns, and the silver loading amount of the outer layer is gradually reduced from the outer surface to the inside in a gradient manner; the middle layer is a polyurethane and graphene oxide composite film with the thickness of 0.03 mm and the pore diameter of 0.1-0.3 mu m, and the graphene oxide content of the middle layer is gradually reduced from the side, connected with the outer layer, of the middle layer inwards in a gradient mode; the inner layer is a silk fibroin modified layer with the thickness of 0.01 mm and the contact angle of 105 degrees, and the proportion of silk fibroin in the inner layer is gradually reduced from the inner surface to the outside in a gradient mode.

Description

Technical Field

[0001] The present invention relates to the technical field of medical gloves, and particularly to a medical anti-infection breathable disposable glove. Background Art

[0002] Currently, the mainstream medical disposable gloves are generally made of natural latex or synthetic materials (nitrile / PVC). Among them, the thickness of natural latex is 0.08 - 0.12 mm, containing 12 - 14% protein, and the moisture permeability is about 200 g / m 2 / 24h. The thickness of synthetic materials is 0.05 - 0.08 mm, and the moisture permeability ≤ 80 g / m 2 / 24h. The protective structure adopted is a single-layer homogeneous membrane structure (without functional partitions), and the surface is smoothed to reduce the friction coefficient.

[0003] However, in clinical trials, it is found that traditional medical gloves have the following structural defects: when the moisture permeability of latex gloves is 200 g / m 2 / 24h, the protein allergy rate is as high as 18%. While the allergy rate of nitrile gloves is reduced to 2%, but the moisture permeability is only 80 g / m 2 / 24h, resulting in the accumulation of hand sweat > 15 mL / h.

[0004] Therefore, there is an inevitable contradiction between moisture permeability and protection. The smooth surface of the glove (Ra = 0.8 - 1.2 μm) results in a droplet attachment rate > 60%, and the inner surface contamination rate during removal is as high as 35%. Therefore, there is an infection risk in surface contact. In addition, the breakage rate of the fingertip and palm areas of the glove accounts for 82% of the overall breakage, which is caused by stress concentration due to the same thickness. Summary of the Invention

[0005] The technical problem to be solved by the present invention is that it is difficult to balance the moisture permeability and protection of traditional medical gloves, and to provide a medical anti-infection breathable disposable glove.

[0006] The technical solution of the present invention is that a medical anti-infection breathable disposable glove includes an outer layer, an intermediate layer, and an inner layer that are sequentially compounded into a gradient composite film from outside to inside;

[0007] The outer layer is a 0.02 mm silver-containing zeolite coating, and the outer surface is provided with a nano-cone array with a height of 5 μm and a spacing of 10 μm, and the silver loading amount of the outer layer decreases gradiently from its outer surface inward;

[0008] The intermediate layer is a composite film of polyurethane and graphene oxide with a thickness of 0.03 mm and a pore size of 0.1 - 0.3 μm, and the graphene oxide content of the intermediate layer decreases gradiently from the side connecting the outer layer inward;

[0009] The inner layer is a silk fibroin modified layer with a thickness of 0.01 mm and a contact angle of 105°, and the proportion of silk fibroin in the inner layer decreases gradually from the inner surface to the outside;

[0010] The palm area of ​​the outer layer is provided with a plurality of regular hexagonal honeycomb patterns, each honeycomb unit formed by the honeycomb patterns is provided with a plurality of micro-cones with a height of 50 μm and a spacing of 20 μm, and the fingertip area and palm area of ​​the outer layer are embedded with aramid nanofiber grids;

[0011] A gradient conical hole is set in the back of hand area of ​​the middle layer, the inlet aperture of the gradient conical hole is 20 μm, the outlet aperture of the gradient conical hole is 50 μm, and the aperture expands linearly along the thickness direction of the middle layer, the inlet of the gradient conical hole and the outlet of the gradient conical hole are respectively close to the inner layer and the outer layer, the inlet section of the gradient conical hole is a hydrophilic area, and the outlet section of the gradient conical hole is a hydrophobic area;

[0012] The outer surface of the outer layer is provided with a TiO 2 / ZnO heterojunction coating, a thermal expansion strip responsive to a temperature of 32°C is built in the wrist area of ​​the inner layer.

[0013] As an embodiment, the silver loading on the outer surface of the outer layer is 2.5 wt %, and the silver loading on the inner surface of the outer layer is 0.5 wt %.

[0014] As an embodiment, the graphene oxide content of a side of the intermediate layer connected to the outer layer is 15%, and the graphene oxide content of a side of the intermediate layer connected to the inner layer is 5%.

[0015] As an embodiment, the inner layer is blended with silk fibroin and polyurethane, the proportion of silk fibroin on the inner surface of the inner layer is 30%, and the proportion of silk fibroin on the outer surface of the inner layer is 10%.

[0016] As an implementation manner, the entrance section depth of the gradient tapered hole is 10 μm, and the contact angle is 0°; the exit section depth of the gradient tapered hole is 30 μm, and the contact angle is 120°.

[0017] As an embodiment, the inlet section of the gradient tapered hole is precisely perfused with PVP solution by a microinjection pump for microfluidic surface treatment, and the outlet section of the gradient tapered hole is passed through a vapor deposition chamber to pass C 4 F 8 Plasma microfluidic surface treatment.

[0018] As an implementation manner, the honeycomb pattern has a side length of 1 mm and a depth of 0.2 mm, and 5 micro-cones are arranged in the honeycomb unit formed by each of the honeycomb patterns. The contact angle between the honeycomb pattern and the micro-cones is greater than 150°.

[0019] As an implementation manner, the wire width of the aramid nanofiber grid is 10 μm and the wire spacing is 200 μm.

[0020] As an implementation manner, the inner layer integrates a pH-sensitive dye.

[0021] The beneficial effects of the present invention compared with the prior art are that the medical anti-infection breathable disposable glove is composed of an outer layer, an intermediate layer, and an inner layer to form a gradient composite film. The so-called gradient composite film refers to a layered functional material system that realizes the synergy of multi-objective performances through the continuous / stepwise change of material composition and functional characteristics in the spatial dimension. The change in material composition is reflected in: the silver loading of the outer layer decreases gradiently from its outer surface inward, the content of graphene oxide in the intermediate layer decreases gradiently from the side connecting the outer layer inward, and the proportion of silk fibroin in the inner layer decreases gradiently from its inner surface outward. The continuous release of silver ions can inhibit bacteria, so the change in the material composition of the outer layer realizes the functions of high antibacterial property on the contact surface and biocompatibility inside. The molecular sieve effect of graphene oxide can physically block viruses and bacteria, so the change in the material composition of the intermediate layer realizes the functions of high barrier property near the epidermis and high moisture permeability inside (the high moisture permeability inside needs to be reflected in combination with the gradient conical holes). The role of silk fibroin is to optimize the touch, so the change in the material composition of the inner layer realizes the functions of low sensitization on the inner surface and interface bonding strength.

[0022] The medical anti-infection breathable disposable glove also realizes the coordinated optimization of protection, moisture permeability, and mechanics through micro-nano structure regulation, which is reflected in the following three aspects. First, the regular hexagonal honeycomb pattern, micro-cones, and nano-cone arrays can reduce the contact area, resulting in a reduced droplet adhesion rate. The silver zeolite coating continuously releases silver ions, resulting in an increased antibacterial rate. Second, the gradient conical holes are combined with the alternating structure of hydrophilic and hydrophobic regions. The so-called alternating structure means that the entrance close to the skin side (inner layer interface) is a hydrophilic region, and the exit close to the environment side (outer layer interface) is a hydrophobic region. The hydrophilic entrance accelerates capillary penetration, and the hydrophobic exit combined with the cone can form an anti-osmosis barrier, so a directional moisture permeability channel is formed. Third, the aramid nanofiber grid can disperse stress, resulting in a reduced breakage rate.

[0023] The optimization of infection prevention and control of the medical anti-infection breathable disposable glove is also reflected in photocatalytic antibacterial and intelligent sealing. TiO 2 / ZnO heterojunction coating generates reactive oxygen under surgical light illumination, and the inactivation rate of Staphylococcus aureus reaches 99.9%. The thermally expandable rubber strip expands upon contact with body temperature to form an airtight structure, creating a physical isolation from the outside.

[0024] Therefore, through the optimization of material composition, micro-nano structure, body temperature-triggered sealing dynamic response mechanism, and light-activated disinfection dynamic response mechanism, the medical anti-infection breathable disposable gloves achieve both moisture permeability and protection through the synergistic effect of multiple parties, and the protection performance is significantly improved compared with traditional medical gloves. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 FIG. is a schematic diagram of the outer layer of the medical anti-infection breathable disposable glove provided by the embodiment of the present invention;

[0026] Figure 2 FIG. is a schematic diagram of the middle layer of the medical anti-infection breathable disposable glove provided by the embodiment of the present invention;

[0027] Figure 3 FIG. is a schematic diagram of the inner layer of the medical anti-infection breathable disposable glove provided by the embodiment of the present invention.

[0028] In the figure: 1, honeycomb pattern; 2, micro-cone; 3, aramid nanofiber grid; 4, gradient tapered hole; 5, thermally expandable rubber strip. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0029] The following will clearly and completely describe the above and other embodiments and advantages of the present invention with reference to the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them.

[0030] In one embodiment, as Figure 1 shown.

[0031] The medical anti-infection breathable disposable gloves provided in this embodiment include an outer layer, an intermediate layer, and an inner layer which are compounded into a gradient composite film from the outside to the inside in sequence; the outer layer is a 0.02 mm silver-containing zeolite coating, and the outer surface is provided with a nanocone array with a height of 5 μm and a spacing of 10 μm, and the silver loading of the outer layer decreases gradually from the outer surface to the inside; the intermediate layer is a composite film of polyurethane and graphene oxide with a thickness of 0.03 mm and a pore size of 0.1-0.3 μm, and the graphene oxide content of the intermediate layer decreases gradually from the side connected to the outer layer to the inside; the inner layer is a silk fibroin modified layer with a thickness of 0.01 mm and a contact angle of 105°, and the silk fibroin ratio of the inner layer decreases gradually from the inner surface to the outside; The palm area of ​​the outer layer is provided with a plurality of regular hexagonal honeycomb patterns 1, and a plurality of micro-cones 2 with a height of 50 μm and a spacing of 20 μm are arranged in the honeycomb units formed by each honeycomb pattern 1. The fingertip area and the palm area of ​​the outer layer are embedded with aramid nanofiber meshes 3; the back of the hand area of ​​the middle layer is provided with gradient conical holes 4, the inlet aperture of the gradient conical holes 4 is 20 μm, the outlet aperture of the gradient conical holes 4 is 50 μm, and the aperture is linearly expanded along the thickness direction of the middle layer, the inlet of the gradient conical holes 4 and the outlet of the gradient conical holes 4 are close to the inner layer and the outer layer respectively, the inlet section of the gradient conical holes 4 is a hydrophilic area, and the outlet section of the gradient conical holes 4 is a hydrophobic area; the outer surface of the outer layer is provided with a 200 nm thick TiO 2 / ZnO heterojunction coating, and a thermal expansion strip 5 with a response temperature of 32°C is built in the inner wrist area.

[0032] In this embodiment, the medical anti-infection breathable disposable gloves can solve the technical problem that it is difficult to balance the moisture permeability and protection of traditional medical gloves. The medical anti-infection breathable disposable gloves are compounded into a gradient composite film by an outer layer, an intermediate layer, and an inner layer. The so-called gradient composite film refers to a layered functional material system that realizes multi-objective performance synergy through continuous / step-by-step changes in material composition and functional properties in the spatial dimension. The change in material composition is reflected in: the silver loading of the outer layer decreases gradually from its outer surface to the inside, the graphene oxide content of the intermediate layer decreases gradually from the side connected to the outer layer to the inside, and the silk protein ratio of the inner layer decreases gradually from its inner surface to the outside. The continuous release of silver ions can inhibit bacteria, so the change in the material composition of the outer layer realizes the function of high antibacterial property of the contact surface and internal biocompatibility. The molecular sieving effect of graphene oxide can physically block viruses and bacteria, so the change in the material composition of the intermediate layer realizes the function of high barrier property near the epidermis and high internal moisture permeability (the internal high moisture permeability needs to be combined with the gradient conical hole 4 to reflect). The role of silk fibroin is to optimize the touch, so the change in the material composition of the inner layer achieves the functions of low sensitization of the inner surface and interface bonding strength.

[0033] In this embodiment, the medical anti-infection breathable disposable glove also realizes the collaborative optimization of protection, moisture permeability, and mechanics through micro-nano structure regulation, which is reflected in the following three aspects. First, the regular hexagonal honeycomb pattern 1, micro-cones 2, and nano-cone arrays can reduce the contact area, resulting in a reduced droplet adhesion rate. The silver zeolite coating continuously releases silver ions, increasing the antibacterial rate. Second, the gradient conical holes 4 cooperate with the alternating structure of the hydrophilic and hydrophobic regions. The so-called alternating structure means that the entrance near the skin side (inner interface) is a hydrophilic region, and the exit near the environment side (outer interface) is a hydrophobic region. The hydrophilic entrance accelerates capillary penetration, and the hydrophobic exit combined with the cone can form an anti-osmosis barrier, thus forming a directional moisture permeation channel. Third, the aramid nanofiber mesh 3 can disperse stress, reducing the breakage rate. The optimization of infection prevention and control of the medical anti-infection breathable disposable glove is also reflected in photocatalytic antibacterial and intelligent sealing. TiO 2 / ZnO heterojunction coating generates reactive oxygen species under surgical lighting, achieving a 99.9% inactivation rate of Staphylococcus aureus. The thermally expandable rubber strip 5 expands upon contact with body temperature to form an airtight structure, creating a physical barrier from the outside. Therefore, the medical anti-infection breathable disposable glove achieves both moisture permeability and protection through the multi-party synergistic effects of material composition optimization, micro-nano structure optimization, body temperature-triggered sealing dynamic response mechanism, and light-activated disinfection dynamic response mechanism, and its protection performance is significantly improved compared to traditional medical gloves.

[0034] In this embodiment, the thermally expandable rubber strip 5 is a smart sealing material based on a temperature-responsive polymer and is used for wrist dynamic sealing in medical anti-infection gloves. Its core materials are carbon nanotubes and thermally expandable microspheres.

[0035] In one embodiment, the silver loading on the outer surface of the outer layer of the medical anti-infection breathable disposable glove is 2.5 wt%, and the silver loading on the inner surface of the outer layer is 0.5 wt%.

[0036] In this embodiment, the silver loading of the outer layer decreases gradiently from its outer surface inward, reflecting an anti-infection mechanism of the medical anti-infection breathable disposable glove. That is, directional bactericide release. The silver zeolite carrier forms an ion concentration gradient in the high-concentration outer layer region (2.5 wt%), and can control the silver ion release rate through Fick's diffusion law. By controlling the diffusion coefficient, the effective antibacterial concentration can be ensured within 8 hours.

[0037] In one embodiment, the graphene oxide content on the side of the intermediate layer connecting the outer layer is 15%, and the graphene oxide content on the side of the intermediate layer connecting the inner layer is 5%.

[0038] In this embodiment, the layer spacing formed by the intermediate layer of graphene oxide sheets allows water vapor molecules to pass through, but blocks viruses and bacteria, and utilizes the Laplace pressure difference generated by the pore size gradient of the gradient conical holes 4 to drive the unidirectional discharge of sweat.

[0039] In one embodiment, the inner layer of the medical anti-infection breathable disposable glove is blended with silk fibroin and polyurethane. The proportion of silk fibroin on the inner surface of the inner layer is 30%, and the proportion of silk fibroin on the outer surface of the inner layer is 10%.

[0040] In this embodiment, the inner layer has the characteristics of low sensitization and optimized touch.

[0041] In one embodiment, the depth of the inlet section of the gradient conical hole 4 of the medical anti-infection breathable disposable glove is 10 μm, the contact angle is 0°, the depth of the outlet section of the gradient conical hole 4 is 30 μm, and the contact angle is 120°. And, the inlet section of the gradient conical hole 4 is subjected to microfluidic surface treatment by precisely perfusion of PVP solution through a micro-injection pump, and the outlet section of the gradient conical hole 4 is subjected to microfluidic surface treatment by introducing C 4 F 8 plasma.

[0042] In this embodiment, the contact angle of the inlet section is 0°, which is super-hydrophilic, doubling the capillary force and increasing the penetration rate. The contact angle of the outlet section is 120°, which is super-hydrophobic, preventing external liquid from re-infiltrating. According to the driving principle of Laplace pressure difference, the conical hole generates a pressure gradient. When the depth of the inlet section is 10 μm and the depth of the outlet section is 30 μm, the formed pressure difference drives the sweat to flow unidirectionally from the inner layer to the outer layer. Through the gradient modification process, the surfaces of the inlet section and the outlet section of the gradient conical hole 4 are further processed.

[0043] In one embodiment, the side length of the honeycomb pattern 1 of the medical anti-infection breathable disposable glove is 1 mm and the depth is 0.2 mm. Five micro-cones 2 are arranged in each honeycomb unit formed by the honeycomb patterns 1, and the contact angle between the honeycomb pattern 1 and the micro-cones 2 is greater than 150°.

[0044] In one embodiment, the line width of the aramid nanofiber grid 3 of the medical anti-infection breathable disposable glove is 10 μm and the line spacing is 200 μm.

[0045] In one embodiment, the inner layer of the medical anti-infection breathable disposable glove integrates a pH-sensitive dye.

[0046] In this embodiment, the pH-sensitive dye is bromocresol purple, which changes color when contacting blood / tissue fluid. Therefore, the medical anti-infection breathable disposable glove has the characteristic of self-indicating damage.

[0047] The specific embodiments described above further elaborate on the object of the invention, the technical solution, and the beneficial effects of the present invention. It should be understood that the above description is only the specific embodiments of the present invention and is not used to limit the protection scope of the present invention. In particular, it is pointed out that for those skilled in the art, any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. Medical anti-infection breathable disposable gloves, characterized in that: It includes an outer layer, an intermediate layer, and an inner layer which are compounded in sequence from the outside to the inside to form a gradient composite film; The outer layer is a 0.02 mm silver-containing zeolite coating, and the outer surface is provided with a nanocone array with a height of 5 μm and a spacing of 10 μm, and the silver loading of the outer layer decreases gradually from the outer surface to the inside; The middle layer is a composite film of polyurethane and graphene oxide with a thickness of 0.03 mm and a pore size of 0.1-0.3 μm, and the content of graphene oxide in the middle layer decreases gradually from the side connected to the outer layer inward; The inner layer is a silk fibroin modified layer with a thickness of 0.01 mm and a contact angle of 105°, and the proportion of silk fibroin in the inner layer decreases gradually from the inner surface to the outside; The palm area of ​​the outer layer is provided with a plurality of regular hexagonal honeycomb patterns, each honeycomb unit formed by the honeycomb patterns is provided with a plurality of micro-cones with a height of 50 μm and a spacing of 20 μm, and the fingertip area and palm area of ​​the outer layer are embedded with aramid nanofiber grids; A gradient conical hole is set in the back of hand area of ​​the middle layer, the inlet aperture of the gradient conical hole is 20 μm, the outlet aperture of the gradient conical hole is 50 μm, and the aperture expands linearly along the thickness direction of the middle layer, the inlet of the gradient conical hole and the outlet of the gradient conical hole are respectively close to the inner layer and the outer layer, the inlet section of the gradient conical hole is a hydrophilic area, and the outlet section of the gradient conical hole is a hydrophobic area; The outer surface of the outer layer is provided with a TiO2 / ZnO heterojunction coating with a thickness of 200 nm, and the wrist area of ​​the inner layer is built with a thermal expansion strip with a response temperature of 32°C.

2. The medical anti-infection breathable disposable gloves according to claim 1, characterized in that: The silver loading on the outer surface of the outer layer is 2.5 wt %, and the silver loading on the inner surface of the outer layer is 0.5 wt %.

3. The medical anti-infection breathable disposable gloves according to claim 1, characterized in that: The graphene oxide content of the side of the intermediate layer connected to the outer layer is 15%, and the graphene oxide content of the side of the intermediate layer connected to the inner layer is 5%.

4. The medical anti-infection breathable disposable gloves according to claim 1, characterized in that: The inner layer is blended with silk fibroin and polyurethane, the proportion of silk fibroin on the inner surface of the inner layer is 30%, and the proportion of silk fibroin on the outer surface of the inner layer is 10%.

5. The medical anti-infection breathable disposable gloves according to claim 1, characterized in that: The inlet section depth of the gradient conical hole is 10 μm, and the contact angle is 0°; the outlet section depth of the gradient conical hole is 30 μm, and the contact angle is 120°.

6. The medical anti-infection breathable disposable gloves according to claim 5, characterized in that: The inlet section of the gradient conical hole is precisely perfused with PVP solution through a microinjection pump for microfluidic surface treatment, and the outlet section of the gradient conical hole is introduced into C4F8 plasma through a vapor deposition chamber for microfluidic surface treatment.

7. The medical anti-infection breathable disposable gloves according to claim 1, characterized in that: The honeycomb pattern has a side length of 1 mm and a depth of 0.2 mm. Five micro-cones are arranged in the honeycomb unit formed by each of the honeycomb patterns. The contact angle between the honeycomb pattern and the micro-cones is greater than 150°.

8. The medical anti-infection breathable disposable gloves according to claim 5, characterized in that: The line width of the aramid nanofiber grid is 10 μm and the line spacing is 200 μm.

9. The medical anti-infection breathable disposable gloves according to claim 1, characterized in that: The inner layer incorporates a pH sensitive dye.

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