A solid beverage of Ganhuangcao and its processing equipment

Abstract

The present invention relates to the field of ganhuangcao processing, and discloses a ganhuangcao solid beverage and processing equipment thereof. The ganhuangcao solid beverage is composed of the following materials: 30-60 parts of ganhuangcao extract; 15-25 parts of kudzu root powder; and 10-15 parts of wolfberry polysaccharide concentrate. By compounding the ganhuangcao extract with kudzu root powder, wolfberry polysaccharide, nano-lecithin and other ingredients, and utilizing the synergistic effect of a nano-delivery system and ingredients, efficient absorption and multi-target regulation of liver-protecting active ingredients are achieved. The ganhuangcao solid beverage processing equipment comprises: a processing barrel; a drive rod coaxially penetrating the top and bottom of the processing barrel, the drive rod being configured to rotate within the processing barrel; and a crushing structure mounted on the drive rod. By synchronously approaching the extrusion plate and the separation plate for extrusion, and coordinating with the dynamic crushing of the moving knife, the material is subjected to the dual effects of continuous shearing and extrusion, and the juice is quickly precipitated and discharged through the separation hole, and the real-time juice separation reduces the viscosity of the material.

Description

Technical Field

[0001] The present invention relates to the field of processing of ganhuangcao, in particular to a ganhuangcao solid beverage and processing equipment thereof Background Art

[0002] Rich in flavonoid active ingredients such as quercetin, kaempferol, and gallic acid, Ganhuangcao is a high-quality raw material for beverage development. Solid beverages, due to their portability, long shelf life, and ease of reconstitution, have become an important direction for Ganhuangcao's deep processing. The processing of Ganhuangcao solid beverages primarily involves the following steps: Fresh Ganhuangcao is cleaned, crushed into granules using a grinder, and then extruded to extract a slurry; the extruded slurry is filtered through a vibrating screen and concentrated to the desired solid content using a double-effect vacuum concentrator; the concentrate is spray-dried to a powder, or pre-frozen and then freeze-dried in a vacuum; the dry powder is mixed with excipients and granulated using wet granulation and fluidized-bed drying.

[0003] The search publication number is: CN217287406U, which discloses a separation and filtration device for preparing a functional beverage made from the herb. The device pours the extract initially prepared from the herb into the cover from the feeding port and allows the finely ground raw materials and impurities mixed in the extract to remain on the surface of the filter plate. Then, the motor is started so that its output shaft drives the rotating block to rotate, and at the same time drives the grinding plate to rotate. During the rotation of the grinding plate, the finely ground raw materials on the surface of the filter plate are ground, thereby extracting the finely ground raw materials, which then drip from the filter screen to the surface of the filter membrane. The extract is then filtered by the filter membrane and flows to the lower inner wall of the filter tank, and finally discharged and collected from the discharge port.

[0004] The juice produced by the existing processing equipment during the crushing process cannot be separated in real time, and the yellow grass material will produce juice with high viscosity during the crushing process. If the juice is not separated from the material in time, the juice will mix with the material to form liquid-solid adhesion. Due to the centrifugal force, the fiber particles will gather to the edge of the cavity, forming a crushing blind area. Summary of the Invention

[0005] In order to solve the problems that existing solid beverages of Ganhuangcao are mostly single ingredients or simply compounded, the bioavailability of flavonoids is low, the synergistic liver protection effect of multiple ingredients is insufficient, and it is difficult to balance taste and functionality, as well as to solve the problem that the juice produced by the existing processing equipment during the crushing process cannot be separated in real time, the juice will mix with the material to form liquid-solid adhesion, and the fiber particles will gather to the edge of the cavity due to centrifugal force, forming a crushing blind spot, the present invention is achieved through the following technical solutions.

[0006] In one aspect, the present invention provides a solid beverage of Herba Camphoratae, which is composed of the following materials:

[0007] 30-60 parts of Herba Camphoratae extract;

[0008] 15-25 parts of kudzu root powder;

[0009] 10-15 parts of wolfberry polysaccharide concentrate;

[0010] 10-15 parts sea buckthorn fruit powder;

[0011] 5-8 parts of tea polyphenols microcapsules;

[0012] 5-10 parts of Agaricus blazei beta-glucan;

[0013] 2-6 parts of Cordyceps militaris adenosine extract;

[0014] 1-5 parts of mogrosides;

[0015] 3-8 parts of nano-lecithin;

[0016] 1-3 parts of selenium-enriched yeast;

[0017] 2-5 parts of magnesium ascorbyl phosphate;

[0018] Black pepper extract 0.5-2 parts.

[0019] The present invention proposes a solid beverage of Herba Cyperi, which achieves efficient absorption and multi-target regulation of liver-protecting active ingredients by compounding Herba Cyperi extract with ingredients such as Pueraria lobata powder, Lycium barbarum polysaccharides, and nano-lecithin, and utilizing the synergistic effect of a nano-delivery system and ingredients. Nano-lecithin and black pepper extract form a liposome delivery system, which encapsulates flavonoids, breaks through the intestinal barrier, and improves the bioavailability of active ingredients such as quercetin; Cordyceps militaris adenosine extract and selenium-rich yeast synergistically regulate key enzymes in alcohol metabolism, accelerate ethanol decomposition, and reduce liver damage; Mogroside replaces traditional sucrose, improving the taste while avoiding the burden of sugar on the liver, and is suitable for people with alcoholic liver damage.

[0020] On the other hand, the present invention also provides a solid beverage processing equipment for Herba Camphorae, including: a processing barrel; a driving rod, which coaxially passes through the top and bottom of the processing barrel, and the driving rod is configured to rotate in the processing barrel; a crushing structure, which is installed on the driving rod, and the crushing structure includes two movable knives, which are connected to the driving rod, and the two movable knives generate radial shear force as the driving rod rotates; an extrusion assembly, including an extrusion plate and a separation plate, the extrusion plate and the separation plate are arranged on the driving rod, the crushing structure is arranged between the extrusion plate and the separation plate, and a separation hole is opened on the separation plate, and the extrusion plate and the separation plate are configured to be able to approach or move away from each other at the same time, for squeezing the Herba Camphorae material and separating the juice; a driving mechanism, which is installed in the processing barrel, and the driving mechanism is connected to the extrusion plate and the separation plate, for driving the extrusion plate and the separation plate to move.

[0021] Preferably, the driving rod includes: a moving groove, which is opened on the surface of the driving rod; a slider, which is connected in the moving groove, and the slider is connected to the movable knife.

[0022] Preferably, the driving rod also includes: an inner cavity, which is opened on the driving rod, a collecting port is opened on the inner wall of the inner cavity, and an opening is provided at the bottom of the inner cavity; a piston is installed in the inner cavity; a connecting rope, one end of which is installed on the slider, and the other end passes through the movable groove and extends into the inner cavity, and is connected to the piston.

[0023] Preferably, the driving rod also includes: a first one-way valve, installed in the collecting port, with the liquid outlet of the first one-way valve facing the inner cavity; a second one-way valve, installed at the bottom opening of the inner cavity, with the liquid inlet of the second one-way valve facing the inner cavity; an elastic member, one end of which is installed on the inner wall of the inner cavity, and the other end is installed on the piston.

[0024] Preferably, the slider includes: an inclined block installed at the bottom of the slider, and the inclined block is arranged in the moving groove.

[0025] Preferably, the driving mechanism includes: a first power source, installed on the top wall of the processing barrel, and the power shaft of the first power source is connected to the extrusion plate; a second power source, installed on the bottom of the processing barrel, and the power shaft of the second power source is connected to the separation plate.

[0026] Preferably, it also includes: a fourth power source installed in the processing barrel; a first transmission wheel installed on the power shaft of the fourth power source; a second transmission wheel installed on the driving rod, and the second transmission wheel is connected to the first transmission wheel through a belt.

[0027] Preferably, the crushing structure further comprises: a fixed knife installed on the driving rod, and the fixed knife is located between the two movable knives.

[0028] Preferably, the driving mechanism includes: a third power source, installed on the processing barrel; a first connecting rod, one end of which is installed on the extrusion plate and the other end is provided with a telescopic slot; a second connecting rod, one end of which is installed on the separation plate and the other end is connected to the telescopic slot; a screw rod, one end of which is connected to the power shaft of the third power source and the other end passes through the extrusion plate and is threadedly connected to the second connecting rod.

[0029] The present invention proposes a solid beverage processing equipment for Herba Camphoratae var. junceae, which is realized by synchronously extruding an extrusion plate and a separation plate, and cooperating with the dynamic crushing of a moving knife, so that under the dual action of continuous shearing and extrusion, the juice is quickly precipitated and discharged through the separation hole, thereby reducing the adhesion of the material to the inner wall of the equipment. The real-time juice separation reduces the viscosity of the material and reduces the load on the moving knife. The two moving knives are driven toward the middle by the extrusion plate when rotating at high speed, forming a composite force of rotational shear and axial compression. When the distance between the moving knives is large, the high-speed rotation can cut off large stems and leaves. When the extrusion plate pushes the distance between the moving knives to shrink, the material is further sheared, and the cell walls are completely destroyed. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Figure 1 This is a schematic diagram of the three-dimensional structure proposed by the present invention.

[0031] Figure 2 This is a schematic cross-sectional view of the processing barrel proposed by the present invention.

[0032] Figure 3 This is a schematic structural diagram of the processing barrel, extrusion plate and separation plate proposed in the present invention.

[0033] Figure 4 This is a schematic cross-sectional view of the extrusion plate and separation plate proposed in the present invention.

[0034] Figure 5 This is a schematic structural diagram of the driving rod, extrusion plate, separation plate and crushing structure proposed in the present invention.

[0035] Figure 6 This is an enlarged partial cross-sectional view of the driving rod and the separation plate proposed in the present invention.

[0036] Figure 7 This is a schematic structural diagram of the first one-way valve proposed in the present invention.

[0037] Figure 8 This is a schematic diagram of the driving mechanism structure of embodiment 4 of the present invention.

[0038] Figure 9 for Figure 8 Schematic cross-sectional view of the first connecting rod and the second connecting rod.

[0039] Figure 10 This is a diagram showing the experimental results of Experiment 1 in Example 1.

[0040] Figure 11 This is a diagram showing the experimental results of Experiment 2 in Example 1.

[0041] Figure 12 This is a graph showing the control experiment results of Experiment 2 in Example 1.

[0042] Figure 13 This is a diagram showing the experimental results of Experiment 3 in Example 1.

[0043] Figure 14 This is a diagram showing the experimental results of Experiment 4 in Example 1.

[0044] Figure 15 This is the bioavailability data diagram in Example 2.

[0045] Figure 16 This is the animal experiment data diagram in Example 2.

[0046] The reference numerals in the figures are:

[0047] 100, processing barrel; 101, first power source; 102, second power source; 103, third power source; 104, screw rod; 105, first connecting rod; 106, second connecting rod;

[0048] 200, extruded plate;

[0049] 300, separation plate;

[0050] 400, driving rod; 401, moving groove; 402, slider; 403, inclined block; 404, inner cavity; 405, piston; 406, elastic member; 407, connecting rope; 408, first one-way valve; 409, second one-way valve;

[0051] 500, fourth power source; 501, first transmission wheel; 502, second transmission wheel;

[0052] 600, crushing structure; 601, fixed knife; 602, movable knife. DETAILED DESCRIPTION

[0053] The present invention is further described below with reference to specific examples. It should be understood that these examples are only used to illustrate the present invention and are not used to limit the scope of protection of the present invention.

[0054] The following describes the embodiments of the present invention through specific examples. Those skilled in the art will readily understand the other advantages and benefits of the present invention from the disclosure herein. The present invention may also be implemented or applied through various other specific embodiments, and the details in this specification may be modified or altered based on different viewpoints and applications without departing from the spirit of the present invention.

[0055] Example 1: Reference Figure 10-14 , a solid beverage of Ganhuangcao, composed of the following materials:

[0056] 45 parts of Herba Camphoratae extract;

[0057] 15 parts of kudzu root powder;

[0058] Lycium barbarum polysaccharide concentrate 10 parts;

[0059] 10 parts of sea buckthorn fruit powder;

[0060] 5 portions of tea polyphenols microcapsules;

[0061] Agaricus blazei beta-glucan 5 parts;

[0062] 2 parts of Cordyceps militaris adenosine extract;

[0063] 1 part of mogroside;

[0064] 3 parts of nano-lecithin;

[0065] 1 part selenium-enriched yeast;

[0066] 2 parts of magnesium ascorbyl phosphate;

[0067] 1 part black pepper extract.

[0068] Among them, the flavonoid content in the extract of the Chinese rhizome of huanghuang is 30%. The extract of the Chinese rhizome of huanghuang can inhibit liver fibrosis and promote liver cell regeneration.

[0069] The puerarin content in kudzu root powder is 8%, and kudzu root powder can alleviate alcoholic liver damage;

[0070] The purity of Lycium barbarum polysaccharide concentrate is 50%. Lycium barbarum polysaccharide is the core active ingredient of Lycium barbarum and has anti-fatigue effects;

[0071] The vitamin C content in seabuckthorn fruit powder is 500mg / 100g. Seabuckthorn fruit powder is rich in vitamin C, and its acidic components can adjust the taste and improve the palatability of beverages.

[0072] Tea polyphenol microcapsules are sustained-release. Tea polyphenols are strong antioxidants, and microencapsulation technology can protect the stability of tea polyphenols.

[0073] The sweetness replacement rate of mogroside is 90%. Mogroside is a natural sweetener with zero calories and does not raise blood sugar. It is suitable for people who control their blood sugar. It also improves the sweetness of beverages and avoids the burden of traditional sugar on the liver.

[0074] The selenium content in selenium-enriched yeast is 1000 μg / g;

[0075] Magnesium ascorbyl phosphate is heat stable;

[0076] The piperine content in black pepper extract is 95%.

[0077] The Ganhuangcao solid beverage of the present invention is based on the "intestinal-liver axis" synergistic regulatory mechanism. Through the triple technological breakthroughs of delivery enhancement, metabolic synergy, and targeted protection, it achieves the trinity effect of "liver protection, immunity, and anti-fatigue". The specific experiments are as follows:

[0078] Experiment 1: Verification of the synergistic antioxidant effect of the composition

[0079] Objective: To verify the synergistic antioxidant capacity of Herba Glechomae var. chinensis extract, seabuckthorn fruit powder and green tea polyphenol microcapsules.

[0080] 1.1 Experimental Materials and Instruments

[0081] Test samples:

[0082] 45 parts of Herba Cynanchifoliae extract, 15 parts of Puerariae lobata powder, 10 parts of Lycium barbarum polysaccharide concentrate, 10 parts of Seabuckthorn fruit powder, 5 parts of Tea Polyphenol Microcapsules, 5 parts of Agaricus blazei Murrill β-glucan, 2 parts of Cordyceps militaris adenosine extract, 1 part of Mogroside, 3 parts of Nano-lecithin, 1 part of Selenium-enriched Yeast, 2 parts of Magnesium Vitamin C Phosphate and 1 part of Black Pepper Extract.

[0083] Control sample: commercially available liver protection tablets (containing 80% silybin).

[0084] Reagents: DPPH (Sigma D9132), DMEM medium (Gibco), fetal bovine serum (FBS, HyClone);

[0085] Equipment: microplate reader (BioTek Synergy H1), CO2 incubator (Thermo371).

[0086] 1.2 Experimental methods

[0087] 1.2.1DPPH free radical scavenging rate

[0088] Sample treatment: Each component was dissolved in PBS (pH 7.4) and diluted in a gradient (0.1-100 μg / mL);

[0089] Testing conditions:

[0090] Add 0.1 mM DPPH ethanol solution and react for 30 min in the dark;

[0091] The detection wavelength was 517 nm, and the IC50 (half maximal inhibitory concentration) was calculated.

[0092] 1.2.2 HepG2 cell oxidative damage model

[0093] Cell culture: HepG2 cells were seeded in 96-well plates (1×10 4 / well), cultured at 37°C, 5% CO2 for 24 h;

[0094] Injury induction: add 200 μM H2O2 for 4 h;

[0095] Intervention treatment: preincubation of samples (10 μg / mL) for 24 h;

[0096] Survival rate detection: CCK-8 reagent (Dojindo) was incubated for 2 h, and the absorbance at 450 nm was measured.

[0097] 1.3 Data Analysis

[0098] Statistical methods: One-way analysis of variance (ANOVA), Tukey post hoc test, data are expressed as mean ± standard deviation (n = 6);

[0099] Software: GraphPad Prism 9.0.

[0100] 1.4 Experimental results (see Figure 10 )

[0101] The antioxidant capacity and cell protection effect of the composition of Example 1 are superior to those of single components or commercially available products, demonstrating the synergistic effect of nano-lecithin delivery + black pepper absorption promotion.

[0102] Experiment 2: Animal model of alcoholic liver injury

[0103] Objective: To compare the liver protection effects of the formula of Example 1 with those of a conventional liver protection formula.

[0104] 2.1 Experimental design

[0105] Animals: SD rats (male, 180–220 g) were purchased from Beijing Weitonglihua Co., Ltd., license number SCXK (Beijing) 2020-0006;

[0106] Group (n=10):

[0107] Normal group: regular feed + normal saline;

[0108] Model group: ethanol gavage (5 g / kg / d, 56% vol);

[0109] Control formula group: model + Herba Camphoratae extract (200 mg / kg / d);

[0110] Example 1: Model + the formulation of Example 1 (500 mg / kg / d).

[0111] Period: The intervention lasted for 4 weeks. Blood and liver tissue were collected after fasting for 12 hours.

[0112] 2.2 Detection indicators

[0113] Serum ALT / AST: fully automatic biochemical analyzer (Hitachi7080);

[0114] Liver tissue MDA / SOD: kit (Nanjing Jiancheng, A003-1 / A001-3);

[0115] Pathological sections: HE staining (Leica RM2235 microtome).

[0116] 2.3 Statistical methods

[0117] Two-tailed t test, data are expressed as mean ± SEM.

[0118] 2.4 Experimental results (see Figure 11 )

[0119] The ALT / AST levels in the high-dose group of the present invention decreased by 71.9% / 69.5%, which was significantly better than that in the control group (p<0.001), and the MDA level decreased by 76.8%, demonstrating the synergistic regulatory effect of the combination of Cordyceps militaris adenosine + selenium-enriched yeast + magnesium vitamin C phosphate on the alcohol metabolism pathway (CYP2E1 / ADH).

[0120] In the formula of Example 1, the combination of magnesium ascorbyl phosphate and selenium-enriched yeast is a key synergistic component for achieving efficient liver protection. The two components work through the following mechanisms:

[0121] The trace element selenium provided by selenium-enriched yeast is the core coenzyme of glutathione peroxidase (GSH-Px), which can directly enhance the activity of liver antioxidant enzymes;

[0122] As a stable derivative of vitamin C, magnesium ascorbyl phosphate can regenerate glutathione (GSH) and enhance the activity of superoxide dismutase (SOD). The two together with the flavonoids in the Herba Ascorbicae extract form a three-level protection system of "free radical scavenging - enzyme activity enhancement - oxidative stress inhibition" (see Experiment 1 DPPH clearance rate and Experiment 2 SOD activity data).

[0123] Based on Experiment 2, two additional control groups were set up:

[0124] Selenium-enriched yeast deficiency group: 1-3 servings of selenium-enriched yeast were removed from the formula, while other ingredients and dosages remained unchanged;

[0125] Ascorbyl phosphate-deficient group: remove "Ascorbyl phosphate-deficient magnesium 2-5 parts" from the formula, and keep other ingredients and dosages unchanged.

[0126] The results of the control experiment (see Figure 12 ).

[0127] Ingredient Necessity Argument:

[0128] After the loss of selenium-enriched yeast or magnesium vitamin C phosphate, the ALT / AST decrease rate decreased by 10.7%-12.1%, respectively, which was significantly lower than that of the present invention group (p<0.01), proving that the two are core synergistic components and the lack of either one will destroy the synergistic enhancement effect of antioxidant enzyme activity.

[0129] The changes in SOD activity and MDA levels further indicate that the two form an inseparable liver protection system with the Herba Glechomae var.

[0130] Experiment 3: Bioavailability Enhancement Verification

[0131] Objective: To verify the synergistic effect of nano-lecithin and black pepper extract on the absorption of flavonoids.

[0132] 3.1HPLC detection conditions

[0133] Instrument: Agilent 1260 Infinity II;

[0134] Chromatographic column: ZORBAXSB-C18 (4.6×250mm, 5μm);

[0135] Mobile phase: acetonitrile: 0.1% phosphoric acid water = 45:55 (v / v);

[0136] Flow rate: 1.0 mL / min;

[0137] Detection wavelength: 370 nm (quercetin);

[0138] Column temperature: 30°C;

[0139] Injection volume: 20 μL.

[0140] 3.2 Subject Protocol

[0141] Population: Healthy volunteers (n=12, half male and half female), signed informed consent;

[0142] Administration: A single oral dose of 50 mg of quercetin containing a traditional formula or the present invention formula;

[0143] Blood collection points: 0h, 0.5h, 1h, 2h, 4h, 6h, 8h, 24h;

[0144] Blood sample processing: heparin anticoagulation, centrifugation (3000 rpm, 10 min) to obtain plasma, and storage at -80℃.

[0145] 3.3 Pharmacokinetic Analysis

[0146] Standard curve: quercetin concentration 0.1-100 ng / mL (R²=0.9993);

[0147] Extraction recovery rate: 85.2%-92.7%;

[0148] Data fitting: non-compartmental model (WinNonlin8.1).

[0149] 3.4 Experimental results (see Figure 13 )

[0150] The bioavailability (AUC) of quercetin in the group of the present invention was increased by 186%, and the time to peak was shortened by 28%, demonstrating the synergistic effect of nano-lecithin and black pepper extract on the absorption of flavonoids.

[0151] Experiment 4: Human food testing

[0152] Subjects: 60 patients with alcoholic fatty liver disease were randomly divided into a control group (placebo) and a test group (formula 1 of this example 3 g / d). The test lasted for 12 weeks.

[0153] Experimental results (see Figure 14 )

[0154] Conclusion: The formula of the present invention achieves synergistic effects of liver damage repair, fat metabolism regulation and anti-fatigue.

[0155] Experiment 4 Supplement: Effects of the Full Ingredient System on Human Food Test Results

[0156] Supplementary analysis: Effects of missing key components on fatigue index

[0157] In the human food test, a "deficient Agaricus blazei β-glucan + Cordyceps militaris adenosine extract group" was added (removing both, while other ingredients remained unchanged). The results showed:

[0158] The improvement rate of fatigue index in the experimental group (full components) was 3.6%;

[0159] The improvement rate of fatigue index in the group lacking Agaricus blazei β-glucan + Cordyceps militaris adenosine was only 2.2% (p<0.05), proving that both are indispensable for the "anti-fatigue" effect by regulating the adenosine metabolic pathway and enhancing mitochondrial function.

[0160] Experiment 1-4 Description

[0161] Sample size and replication: n = 10 for animal experiments to meet statistical power (Power > 0.8), and n = 6 for cell experiments;

[0162] Positive control selection: Commercially available liver protection tablets (silybin) were used as the gold standard control;

[0163] Clinical relevance: The human trial dose is calculated based on body weight (3-5g per day for a 70kg adult), which is within the safety range.

[0164] Compliance of the test method: HPLC conditions refer to the quercetin content determination method of the 2020 edition of the Chinese Pharmacopoeia.

[0165] Example 2: A solid beverage of Herba Camphoratae, comprising the following ingredients:

[0166] 33 parts of Herba Camphoratae extract;

[0167] 16 parts of kudzu root powder;

[0168] Lycium barbarum polysaccharide concentrate 11 parts;

[0169] 12 parts sea buckthorn fruit powder;

[0170] 6 portions of tea polyphenols microcapsules;

[0171] Agaricus blazei beta-glucan 6 parts;

[0172] 3 parts of Cordyceps militaris adenosine extract;

[0173] 2 parts of mogrosides;

[0174] 4 parts of nano-lecithin;

[0175] 2 parts of selenium-enriched yeast;

[0176] 3 parts of magnesium ascorbyl phosphate;

[0177] 2 parts black pepper extract.

[0178] The difference between the second embodiment and the first embodiment is: Figure 15 and Figure 16 , an optimal formula designed for people with mild liver damage or daily health care needs. By adjusting the ratio of Herba Lycopodii extract and auxiliary materials, it optimizes taste and economy while ensuring liver protection effects.

[0179] Add subitems to Experiment 3 of Example 1 to supplement the bioavailability data (see Figure 15 ).

[0180] The quercetin bioavailability (AUC) of Example 2 was increased by 159% compared to the traditional formula. Although slightly lower than that of Example 1, it was still significantly better than the traditional formula.

[0181] Tmax (peak time) and t1 / 2 (half-life) are close to those in Example 1, indicating that the core delivery system (nanophosphatidylcholine + black pepper extract) can achieve rapid absorption and sustained release when the ratio is 3-8 parts / 0.5-2 parts.

[0182] Dose-dependent verification of liver protective effect

[0183] Animal experimental data (see Figure 16 )

[0184] The ALT / AST reduction rate of Example 2 was slightly lower than that of Example 1, but still 1.86 times that of the control formula group. The low-dose formula is suitable for prevention scenarios;

[0185] The SOD activity increased by 74% compared with the control formula group, verifying that selenium-enriched yeast and magnesium vitamin C phosphate can still effectively activate antioxidant enzymes at a moderate ratio.

[0186] In Example 2, by reducing the proportion of Herba Lycopodii extract and increasing seabuckthorn fruit powder and wolfberry polysaccharides, the following technical advantages are achieved:

[0187] Taste optimization: The acidic components of seabuckthorn fruit powder and mogrosides synergistically regulate sweetness and acidity, improving palatability by 30% (verified by sensory evaluation of 50 people);

[0188] Intestinal barrier protection: Agaricus blazei β-glucan and Lycium barbarum polysaccharide form a mucosal protector, which, combined with nano-lecithin liposome delivery, further enhances the intestinal absorption efficiency of flavonoids (2.1 times higher than that of single Herba Glehniae extract).

[0189] Metabolic synergy: The ratio of Cordyceps militaris adenosine extract and black pepper extract is optimized to specifically regulate the activity of alcohol dehydrogenase (ADH) and accelerate the clearance of acetaldehyde, a product of alcohol metabolites. It is suitable for preventive liver protection for people who frequently socialize.

[0190] Example 3: Reference Figure 1-Figure 7 A yellow grass solid beverage processing device includes: a processing barrel 100; a driving rod 400, which coaxially passes through the top and bottom of the processing barrel 100 and is configured to rotate within the processing barrel 100; a crushing structure 600, which is mounted on the driving rod 400 and includes two movable knives 602, which are connected to the driving rod 400 and generate radial shear force as the driving rod 400 rotates; an extrusion assembly, which includes an extrusion plate 200 and a separation plate 300. The extrusion plate 200 and the separation plate 300 are arranged on the driving rod 400, the crushing structure 600 is arranged between the extrusion plate 200 and the separation plate 300, and a separation hole is opened on the separation plate 300. The extrusion plate 200 and the separation plate 300 are arranged to be able to approach or move away from each other at the same time, and are used to extrude the yellow grass material and separate the juice; the driving mechanism is installed in the processing barrel 100, and the driving mechanism is connected to the extrusion plate 200 and the separation plate 300, and is used to drive the extrusion plate 200 and the separation plate 300 to move.

[0191] The driving rod 400 drives the two movable knives 602 to rotate at high speed in the processing barrel 100, so that the yellow grass material between the extrusion plate 200 and the separation plate 300 can be crushed. A cover plate is provided on the extrusion plate 200. By opening the cover plate, the yellow grass material can be directly placed into the crushing area. During the crushing process, the extrusion plate 200 and the separation plate 300 can be driven close to each other by the driving mechanism, and pressure is applied to the yellow grass material, so that the juice in the yellow grass is squeezed out and separated from the separation plate 300 to the bottom area of the processing barrel 100. Moreover, the driving rod 400 is in active contact with the extrusion plate 200 and the separation plate 300. When the driving rod 400 rotates, the movement of the extrusion plate 200 and the separation plate 300 will not be affected.

[0192] The driving rod 400 includes: a moving groove 401, which is opened on the surface of the driving rod 400; a slider 402, which is connected in the moving groove 401, and the slider 402 is connected to the moving knife 602; an inner cavity 404, which is opened on the driving rod 400, and a collecting port is opened on the inner wall of the inner cavity 404, and an opening is provided at the bottom of the inner cavity 404; a piston 405, which is installed in the inner cavity 404; a connecting rope 407, one end of which is installed on the slider 402, and the other end passes through the moving groove 401 and extends into the inner cavity 404, and is connected to the piston 405; a first one-way valve 408, which is installed in the collecting port, and the liquid outlet of the first one-way valve 408 faces the inner cavity 404; a second one-way valve 409, which is installed at the bottom opening of the inner cavity 404, and the liquid inlet of the second one-way valve 409 faces the inner cavity 404; an elastic member 406, one end of which is installed on the inner wall of the inner cavity 404, and the other end is installed on the piston 405.

[0193] The movable knife 602 is connected to the movable groove 401 on the surface of the driving rod 400 through the slider 402, so that the movable knife 602 can move along the axial direction of the driving rod 400 and can also rotate with the radial rotation of the driving rod 400. The movement directions of the two are arranged perpendicularly. The movable knife 602 can move on the driving rod 400 without affecting the rotation of the movable knife 602 driven by the driving rod 400. The moving power of the movable knife 602 is driven by the extrusion plate 200 or the separation plate 300, that is, when the extrusion plate 200 or the separation plate 300 is pressed, the movable knife 602 is rotated. When the movable blade 602 moves on the driving rod 400, the movable blade 602 can be pushed to move, and the movable blade 602 drives the slider 402 to slide linearly in the movable groove 401. In addition, a gasket is provided between the movable blade 602 and the extrusion plate 200 or the separation plate 300. The gasket can improve the smoothness of the rotation of the movable blade 602 and avoid friction between the movable blade 602 and the extrusion plate 200 or the separation plate 300. By utilizing the movement of the movable blade 602 and the slider 402, the slider 402 can pull the connecting rope 407 during the movement to move the movable blade 602. The movement of the slider 402 is converted into the movement of the piston 405. The liquid outlet of the first one-way valve 408 is directed toward the inner cavity 404, ensuring that the juice can only flow into the inner cavity 404 in one direction; the liquid inlet of the second one-way valve 409 is directed toward the inner cavity 404, ensuring that the juice is smoothly discharged from the inner cavity 404; the elastic member 406 is a spring or an elastic block, and the elastic member 406 provides elastic force for the reset of the piston 405. When the piston 405 moves away from the collection port, a negative pressure is formed in the inner cavity 404, and the yellow grass is crushed. The juice produced during the process passes through the collection port and enters the inner cavity 404 through the first one-way valve 408. When the separation plate 300 is reset, the elastic member 406 drives the piston 405 to reset. The piston 405 pulls the connecting rope 407, and the connecting rope 407 pulls the slider 402 and the movable knife 602, causing the movable knife 602 to reset. When the piston 405 moves toward the collection port, the juice is squeezed by the piston 405 and discharged from the bottom opening of the inner cavity 404 through the second one-way valve 409, completing the juice separation.

[0194] The slider 402 includes an inclined block 403 installed at the bottom of the slider 402 , and the inclined block 403 is disposed in the moving groove 401 .

[0195] The above-mentioned inclined block 403 is set on the slider 402. When the slider 402 moves in the moving groove 401, the inclined block 403 also moves in the moving groove 401 together with the slider 402. The inclined block 403 can use the inclined surface to squeeze out or push out the material accumulated in the moving groove 401, thereby ensuring the smooth movement of the slider 402.

[0196] The driving mechanism includes: a first power source 101, installed on the top wall of the processing barrel 100, and the power shaft of the first power source 101 is connected to the extrusion plate 200; a second power source 102, installed on the bottom of the processing barrel 100, and the power shaft of the second power source 102 is connected to the separation plate 300.

[0197] The driving mechanism includes multiple implementation methods. In the third embodiment, the extrusion plate 200 is driven by the first power source 101 and moves axially in the processing barrel 100. The separation plate 300 is driven by the second power source 102 and moves axially in the processing barrel 100. The first power source 101 and the second power source 102 both use hydraulic cylinders, and air cylinders can also be used. The extrusion plate 200 and the separation plate 300 can move toward the middle at the same time, or the extrusion plate 200 can be controlled to move separately, or the separation plate 300 can be controlled to move toward the extrusion plate 200 separately.

[0198] It also includes: a fourth power source 500, installed in the processing barrel 100; a first transmission wheel 501, installed on the power shaft of the fourth power source 500; a second transmission wheel 502, installed on the driving rod 400, and the second transmission wheel 502 is connected to the first transmission wheel 501 through a belt.

[0199] The fourth power source 500 serves as the driving source of the driving rod 400 and can drive the belt to move through the first transmission wheel 501. The belt then drives the second transmission wheel 502 and the driving rod 400 to rotate. The driving rod 400 can drive the movable knife 602 and the fixed knife 601 to rotate.

[0200] The crushing structure 600 further includes a fixed knife 601 mounted on the driving rod 400 , and the fixed knife 601 is located between the two movable knives 602 .

[0201] The two movable knives 602 are connected to the driving rod 400, and generate radial shear force as the driving rod 400 rotates, which is used to crush the yellow grass material. The fixed knife 601 is located between the two movable knives 602. The movable knife 602 cooperates with the fixed knife 601 to form a more efficient crushing effect and improve the degree of material crushing.

[0202] Example 4: The difference between this example 4 and example 3 is that, Figure 8 and Figure 9The driving mechanism includes: a third power source 103, installed on the processing barrel 100; a first connecting rod 105, one end of which is installed on the extrusion plate 200, and the other end is provided with a telescopic slot; a second connecting rod 106, one end of which is installed on the separation plate 300, and the other end is connected to the telescopic slot; a screw rod 104, one end of which is connected to the power shaft of the third power source 103, and the other end passes through the extrusion plate 200 and is threadedly connected to the second connecting rod 106.

[0203] The driving mechanism is another implementation method. The third power source 103 drives the screw rod 104 to rotate, so that the extrusion plate 200 and the separation plate 300 move relative to each other to achieve the extrusion function. The third power source 103 uses a servo motor and can also use a stepping motor.

[0204] During use, open the cover on the extrusion plate 200, and evenly put an appropriate amount of yellow grass material into the crushing area between the extrusion plate 200 and the separation plate 300. After the feeding is completed, close the cover to prevent the material from splashing during the processing. Start the fourth power source 500, and the power shaft of the fourth power source 500 drives the first transmission wheel 501 to rotate. Through the belt transmission, the second transmission wheel 502 installed on the driving rod 400 rotates, and then drives the driving rod 400 to rotate at high speed in the processing barrel 100. The driving rod 400 drives the two The movable blade 602 and the fixed blade 601 rotate together, and the two movable blades 602 generate radial shear force with the radial rotation of the driving rod 400, and cooperate with the fixed blade 601 located between the two movable blades 602 to efficiently crush the yellow grass material in the crushing area. During the crushing process, since the movable blade 602 is connected to the movable groove 401 on the surface of the driving rod 400 through the slider 402, the movable blade 602 can rotate with the driving rod 400 and, if pushed by the extrusion plate 200 or the separation plate 300, can also move axially along the driving rod 400.

[0205] If it is necessary to extrude the material at the same time, start the first power source 101 and the second power source 102. The power shaft of the first power source 101 pushes the extrusion plate 200 to move axially downward in the processing barrel 100, and the power shaft of the second power source 102 pushes the separation plate 300 to move axially upward in the processing barrel 100. The extrusion plate 200 and the separation plate 300 move toward the middle at the same time to apply pressure to the crushed yellow grass material. If only the movement of the extrusion plate 200 or the separation plate 300 needs to be controlled separately, start the corresponding power source separately, start the first power source 101 separately to move the extrusion plate 200 downward to extrude the material; or start the second power source 102 separately to move the separation plate 300 upward to extrude the material.

[0206] As the squeezing plate 200 and the separating plate 300 move closer together, the force exerted on the yellow grass material gradually increases, fully extracting the juice from the yellow grass. The squeezed juice passes through the separation holes in the separating plate 300 and is then separated from the bottom area of the processing barrel 100, completing the separation of the juice from the solid residue. When the squeezing and juice separation process is complete, the drive mechanism is controlled to reset the squeezing plate 200 and the separating plate 300.

[0207] During the movement of the extrusion plate 200 and the separation plate 300, the extrusion plate 200 or the separation plate 300 pushes the movable knife 602 to move, and the movable knife 602 drives the slider 402 to slide linearly in the moving groove 401 on the surface of the driving rod 400. When the inclined block 403 at the bottom of the slider 402 moves in the moving groove 401, the inclined surface is used to squeeze out or push out the materials accumulated in the moving groove 401, ensuring the smooth movement of the slider 402. At the same time, the slider 402 pulls the connecting rope 402 during the movement. 07. The connecting rope 407 drives the piston 405 to move in the inner cavity 404 of the driving rod 400. When the piston 405 moves away from the collecting port, a negative pressure is formed in the inner cavity 404. The juice produced during the crushing process of the yellow grass passes through the collecting port and enters the inner cavity 404 through the first one-way valve 408; when the piston 405 moves toward the collecting port, the juice is squeezed by the piston 405 and discharged from the bottom opening of the inner cavity 404 through the second one-way valve 409, thereby realizing the collection of the juice.

[0208] In summary, compared with the existing technology, it has the following beneficial effects:

[0209] In this solution, the extrusion plate 200 and the separation plate 300 are synchronously brought close to each other for extrusion, and the dynamic crushing of the movable blade 602 is coordinated, so that under the dual effects of continuous shearing and extrusion, the juice is quickly precipitated and discharged through the separation hole, reducing the adhesion of the material to the inner wall of the equipment. The real-time juice separation reduces the viscosity of the material and reduces the load on the movable blade 602.

[0210] When the two moving knives 602 rotate at high speed, they are driven by the extrusion plate 200 to move closer to the middle, forming a combined force of rotational shear and axial compression. When the distance between the moving knives 602 is large, the high-speed rotation can cut off large stems and leaves. When the extrusion plate 200 pushes the distance between the moving knives 602 to decrease, the material is further sheared, completely destroying the cell wall.

[0211] The movement of the movable knife 602 is converted into juice collection power through the piston 405 and the one-way valve built into the driving rod 400. When the slider 402 moves, it pulls the piston 405 to form a negative pressure, and the juice is sucked in through the first one-way valve 408. When resetting, the piston 405 squeezes the juice and discharges it through the second one-way valve 409, realizing closed automatic collection and preventing juice residue from breeding bacteria or clogging the equipment.

[0212] By integrating the crushing, squeezing, and juice separation functions into the processing barrel 100, material transfer equipment and manual operations are reduced, thereby improving production capacity.

[0213] Thus, although the invention has been described herein with reference to specific embodiments thereof, freedom of modification, various changes and substitutions are contemplated within the foregoing disclosure, and it should be understood that in some cases, some features of the invention will be employed without the corresponding use of other features without departing from the scope and spirit of the claimed invention. Thus, many modifications may be made to adapt a particular environment or material to the true scope and spirit of the invention. The invention is not intended to be limited to the specific terminology used in the claims below and / or to the specific embodiments disclosed as the best mode contemplated for carrying out the invention, but the invention is intended to include any and all embodiments and equivalents falling within the scope of the appended claims. Thus, the scope of the invention will be determined solely by the appended claims.

Claims

1. A solid beverage processing equipment for Ganhuangcao, characterized in that: include: Processing barrel (100); A driving rod (400) coaxially passes through the top and bottom of the processing barrel (100), and the driving rod (400) is configured to rotate within the processing barrel (100); A crushing structure (600) is mounted on the driving rod (400). The crushing structure (600) includes two movable knives (602) connected to the driving rod (400). The two movable knives (602) rotate with the driving rod (400) to shear and crush the material. The extrusion assembly comprises an extrusion plate (200) and a separation plate (300), wherein the extrusion plate (200) and the separation plate (300) are sleeved on a driving rod (400), a crushing structure (600) is arranged between the extrusion plate (200) and the separation plate (300), a separation hole is opened on the separation plate (300), and the extrusion plate (200) and the separation plate (300) are arranged to be able to move closer or farther away at the same time, so as to be used for extruding the yellow grass material and separating the juice; A driving mechanism is installed in the processing barrel (100), the driving mechanism is connected to the extrusion plate (200) and the separation plate (300), and is used to drive the extrusion plate (200) and the separation plate (300) to move; The driving rod (400) comprises: A movable groove (401) is provided on the surface of the driving rod (400); A slider (402) is connected to the movable groove (401), and the slider (402) is connected to the movable knife (602); The driving rod (400) further comprises: An inner cavity (404) is provided on the driving rod (400), a collecting port is provided on the inner wall of the inner cavity (404), and an opening is provided at the bottom of the inner cavity (404); A piston (405) is installed in the inner cavity (404); A connecting rope (407), one end of which is mounted on the slider (402), and the other end of which passes through the movable groove (401) and extends into the inner cavity (404), and is connected to the piston (405); The driving rod (400) further comprises: a first one-way valve (408) installed in the collecting port, with the liquid outlet of the first one-way valve (408) facing the inner cavity (404); A second one-way valve (409) is installed at the bottom opening of the inner cavity (404), with the liquid inlet of the second one-way valve (409) facing the inner cavity (404); The elastic member (406) has one end mounted on the inner wall of the inner cavity (404) and the other end mounted on the piston (405).

2. The solid beverage processing equipment of Ganhuangcao according to claim 1, characterized in that: The slider (402) includes: The inclined block (403) is installed at the bottom of the slider (402), and the inclined block (403) is set in the movable groove (401).

3. The solid beverage processing equipment of Ganhuangcao according to claim 1, characterized in that: The driving mechanism comprises: A first power source (101) is installed on the top wall of the processing barrel (100), and a power shaft of the first power source (101) is connected to the extrusion plate (200); The second power source (102) is installed at the bottom of the processing barrel (100), and the power shaft of the second power source (102) is connected to the separation plate (300).

4. The solid beverage processing equipment of Ganhuangcao according to claim 1, characterized in that: Also includes: A fourth power source (500) is installed in the processing barrel (100); A first transmission wheel (501) is mounted on a power shaft of a fourth power source (500); The second transmission wheel (502) is installed on the driving rod (400), and the second transmission wheel (502) is connected to the first transmission wheel (501) through a belt.

5. The Huangcao solid beverage processing equipment according to claim 1, characterized in that: The pulverizing structure (600) further includes: The fixed knife (601) is mounted on the driving rod (400), and the fixed knife (601) is located between the two movable knives (602).

6. The Ganhuangcao solid beverage processing equipment according to claim 1, characterized in that: The driving mechanism comprises: A third power source (103) is installed on the processing barrel (100); A first connecting rod (105) has one end mounted on the extrusion plate (200) and the other end provided with a telescopic slot; A second connecting rod (106), one end of which is mounted on the separation plate (300) and the other end of which is connected to the telescopic slot; The screw rod (104) has one end connected to the power shaft of the third power source (103), and the other end passes through the extrusion plate (200) and is threadedly connected to the second connecting rod (106).

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