Special anti-freezing skincare essence for children and process thereof

Abstract

The invention relates to the technical field of daily chemicals, and discloses a special anti-freezing skincare essence for children and a process thereof, and the special anti-freezing skincare essence comprises the following raw materials in percentage by mass: 8.0-12.0% of refined wool fat; 3.0%-4.0% of a candida yeast fermentation lipid; 3.5%-4.2% of a maintaining agent; 1.5%-2.5% of linolenic acid glyceride; 4.5% to 5.5% of polyglycerol-9 distearate; 5.0% to 7.0% of a regulating agent; 2.0% to 5.0% of cane sugar; 1.2%-1.8% of a reinforcing agent; 0.3%-0.5% of low temperature type xanthan gum; and 57.5%-71% of deionized water. By adopting the technical scheme of compounding and adding 8-12% of refined wool fat and 2-5% of cane sugar, and controlling the content of branched fatty acid of the wool fat and the molar ratio of cane sugar to trehalose, the technical effects of no crystallization at low temperature and rheology recovery rate greater than or equal to 90% are achieved. Compared with a scheme of using common wool fat or a single humectant in the prior art, the problems of phase separation caused by solubility mismatch and low-temperature crystallization caused by excessive sucrose are solved.

Description

Technical Field

[0001] The present invention relates to the technical field of household kitchens, and specifically to a special anti-freezing skin care essence for children and its process. Background Technique

[0002] In the field of children's skin care, many existing children's anti-freezing skin care products have exposed many problems that need to be solved urgently in practical applications.

[0003] From the perspective of stability, many products choose ordinary lanolin or single moisturizers. These components are extremely prone to phase separation due to solubility mismatch in low-temperature environments. Take industrial lanolin as an example. Its solubility parameter often causes the mixed solubility parameter of the system to exceed the reasonable range, destroying the uniform stability of the product. When sucrose is used as a moisturizer, if the content exceeds 5%, sucrose molecules will gradually aggregate and form crystals in low-temperature environments, which not only affects the appearance texture of the product but also reduces the uniform distribution of active ingredients, resulting in a significant decline in the emulsion stability after freeze-thaw cycles and making it difficult to continuously provide stable protection for children's skin.

[0004] In terms of the emulsification process, traditional children's skin care products mostly rely on the single-stage homogenization emulsification process of mechanical shearing. Although this process is relatively simple to operate, at the molecular level, it cannot effectively guide the orderly arrangement of liquid crystal molecules. The disordered arrangement of liquid crystal molecules directly leads to an increase in the enthalpy of phase change, making the energy stability of the product poor when the temperature changes. At the same time, this disordered arrangement also causes fluctuations in the barrier performance, and the skin barrier is crucial for protecting children's delicate skin. The instability of the barrier performance makes children's skin more vulnerable to external stimuli in cold environments, with a high clinical chapping index, seriously affecting the healthy state of children's skin.

[0005] In terms of the extreme low-temperature protection ability, the current anti-freezing products relying on empirical formulas have obvious shortcomings. In extremely cold regions or under extreme low-temperature conditions, the lipids in the products are prone to polymorphic transformation. This polymorphic transformation will cause a sharp decline in the skin barrier function, with a decline of up to 83%. After the skin barrier is damaged, the transdermal water loss will increase significantly, making children's skin unable to effectively resist the invasion of cold and dry environments and unable to meet the skin care needs of children in extreme low-temperature environments. Summary of the Invention

[0006] Aiming at the deficiencies of the existing technology, the present invention provides a special anti-freezing skin care essence for children and its process, which solves the problems of phase separation caused by solubility mismatch and low-temperature crystallization caused by excessive sucrose.

[0007] To achieve the above objectives, the present invention is realized through the following technical solutions: A special anti-freezing skin care essence for children, comprising raw materials in the following mass percentages:

[0008] 8.0% to 12.0% refined lanolin;

[0009] 3.0% to 4.0% Candida fermented lipids;

[0010] 3.5% to 4.2% preservative;

[0011] 1.5% to 2.5% glycerol linolenate;

[0012] 4.5% to 5.5% polyglyceryl-9 distearate;

[0013] 5.0% to 7.0% regulator;

[0014] 2.0% to 5.0% sucrose;

[0015] 1.2% to 1.8% enhancer;

[0016] 0.3% to 0.5% low-temperature xanthan gum;

[0017] 57.5% to 71% deionized water.

[0018] Preferably, the preservative is one of phytosphingosine or ceramide IIIB complex, the regulator is one of trimethylglycine or trehalose eutectic, and the enhancer is one of hydrogenated lecithin or cholesterol complex.

[0019] Preferably, the molar ratio of sucrose to regulator ≤ 1:3.

[0020] Preferably, the iodine value content of glycerol linolenate ≥ 160 gl 2 / 100g.

[0021] Preferably, the refined lanolin contains 45% to 50% branched-chain fatty acids and the iodine value is 18 to 25 gl 2 / 100g.

[0022] In addition, the present invention also provides a process for a children's special antifreeze skin care essence, including the following steps:

[0023] Step 1, preparation of the oil phase: Add refined lanolin, glycerol linolenate and polyglyceryl-9 distearate to the oil phase pot, stir until completely melted to form a uniform oil phase system;

[0024] Step 2, preparation of the water phase: Add deionized water to the water phase pot, slowly stir and add low-temperature xanthan gum, then add sucrose, preservative, regulator and enhancer, and continue to stir until all components are fully dissolved to obtain a uniform water phase;

[0025] Step 3: Emulsification. Slowly add the oil phase into the water phase pot, and start high-speed stirring until the oil phase and the water phase are fully emulsified to form a stable emulsion.

[0026] Step 4: Cooling. After emulsification is completed, stop high-speed stirring. When the emulsion cools down to 40 - 45 °C, add Candida fermented lipids and stir until they are evenly dispersed in the emulsion.

[0027] Step 5: Homogenization. Transfer the emulsion to a homogenizer to homogenize and refine the emulsion particles.

[0028] Preferably, the stirring speed for preparing the oil phase is 30 - 50 r / min, and the temperature is 70 - 80 °C.

[0029] Preferably, the stirring speed for preparing the water phase is 20 - 40 r / min.

[0030] Preferably, the stirring speed for emulsification is 1000 - 1500 r / min.

[0031] Preferably, the homogenization pressure is controlled at 15 - 25 MPa.

[0032] The present invention provides a special antifreeze skin care essence for children and its process. It has the following beneficial effects:

[0033] 1. By adopting the technical scheme of compound addition of refined lanolin (8 - 12%) and sucrose (2 - 5%), and controlling the content of branched-chain fatty acids in lanolin (45 - 50%) and the molar ratio of sucrose - trehalose (≤1:3), the present invention achieves the technical effects of no crystallization at low temperature and a rheological recovery rate ≥90%. Compared with the prior art that uses ordinary lanolin or a single humectant (such as glycerol), it solves the problems of phase separation caused by solubility mismatch (such as the δ of industrial lanolin = 18.9 leading to an excessive δ_mix of the system) and low-temperature crystallization caused by excessive sucrose (>5%). After freeze-thaw cycles, the emulsion stability is increased by more than 3 times.

[0034] 2. By adopting the technical scheme of inducing the directional arrangement of liquid crystal molecules with pulsed electric fields (1.0 - 2.0 kV / cm, pulse width of 40 - 60 μs) and combining with a phase separation emulsification process, the present invention achieves the technical effect of increasing the liquid crystal order by 40% (the full width at half maximum of XRD is reduced by 30%). Compared with the prior art that only relies on mechanical shearing emulsification processes (such as single-stage homogenization), it solves the problems of increased phase transition enthalpy (ΔH > 15 J / g) and fluctuating barrier performance caused by disordered molecular arrangement. The clinical chapping index (0.3 ± 0.1) is reduced by more than 60% compared with traditional products.

[0035] 3. The present invention adopts a bionic compounding technical solution of fermented lipids (3.0 - 4.0%) of Candida and phytosphingosine (3.5 - 4.2%). By simulating the lipid composition of children's skin, it achieves the technical effect of dual functions of stratum corneum repair and low-temperature protection. Compared with the existing closed-formulations that only rely on mineral oil or synthetic esters (such as vaseline-based products), it solves the problems of skin dependence and poor air permeability caused by long-term use. After testing on 30 children, the irritation reaction rate is 0%, and the skin water content increases by 25% after continuous use for 14 days.

[0036] 4. The present invention adopts the Landau-deGennes continuum theory model and the Hildebrand solubility parameter optimization technical solution. By precisely regulating the lipid order parameter and solubility matching degree in the formula, it achieves the technical effect of reducing the critical temperature of lipid phase change from -15°C to -25°C. Compared with the existing anti-freezing products that rely on empirical formulas (such as simple closed-form oils), it solves the deficiency that the barrier function drops by 83% due to lipid crystal form transformation at extremely low temperatures, and makes the transdermal water loss (TEWL) stable below 12.3 g / (m 2 ·h) at -25°C. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] Figure 1 It is a process flow chart of the anti-freezing skin care essence in the present invention. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0038] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0039] Please refer to the attached Figure 1 , the embodiments of the present invention provide a special anti-freezing skin care essence for children, including the following raw materials by mass percentage:

[0040] 8.0% - 12.0% of refined lanolin, which has good moisturizing performance, can form a protective film on the surface of children's skin, prevent water loss, play a role in moisturizing and locking water, help the skin resist cold and dry air, and prevent the skin from cracking due to water loss;

[0041] 3.0% to 4.0% of Candida fermented lipids, which are similar to the natural lipid structure of the skin, have good skin affinity, can quickly penetrate into the skin, supplement the lipids required by the skin, enhance the skin's barrier function, improve the skin's resistance, and help prevent the damage of the skin from adverse environments such as cold and dryness outside;

[0042] 3.5% to 4.2% of a maintaining agent;

[0043] 1.5% to 2.5% of glycerol linolenate, rich in unsaturated fatty acids, has the effect of nourishing the skin, can penetrate deep into the bottom layer of the skin, provide nutrition for the skin, keep the skin moist and healthy, and enhance the skin's tolerance to cold environments;

[0044] 4.5% to 5.5% of polyglyceryl-9 distearate, as an emulsifier, can evenly mix the oil phase and the water phase to form a stable emulsion structure, ensure the texture of the skin care essence is uniform and delicate, easy to apply and absorb, and at the same time also helps other components to be evenly distributed on the skin surface to better play the skin care role;

[0045] 5.0% to 7.0% of a regulator;

[0046] 2.0% to 5.0% of sucrose, which is a natural humectant, can absorb the moisture in the air and retain it on the skin surface, increase the skin humidity, keep the skin moist, and at the same time also has a certain antioxidant effect, helping to reduce the oxidative damage of the skin in cold weather;

[0047] 1.2% to 1.8% of a strengthener;

[0048] 0.3% to 0.5% of low-temperature xanthan gum, which has thickening and stabilizing effects, can regulate the viscosity and rheology of the skin care essence, make it have a suitable texture, facilitate application and use, and at the same time can also improve the stability of the essence in low-temperature environments, preventing ingredient precipitation or stratification;

[0049] 57.5% to 71% of deionized water, as a solvent, can dissolve and disperse other water-soluble components, make various components evenly mix together to form a stable skin care essence system, and at the same time supplement water for the skin, which is the basis for maintaining the normal physiological functions of the skin.

[0050] The maintaining agent is one of phytosphingosine or ceramide IIIB complex, the regulator is one of trimethylglycine or trehalose eutectic, and the strengthener is one of hydrogenated lecithin or cholesterol complex.

[0051] The molar ratio of sucrose to the regulator ≤ 1:3.

[0052] The iodine value content of glycerol linolenate ≥ 160 gl 2 / 100 g.

[0053] The refined lanolin contains 45% - 50% of branched-chain fatty acids, and the iodine value is 18 - 25 gl / 100 g. 2 / 100 g.

[0054] In addition, the present invention also provides a process for a special anti-freezing skin care essence for children, comprising the following steps:

[0055] Step 1, preparation of the oil phase: Add refined lanolin, glycerol linolenate, and polyglyceryl-9 distearate to the oil phase pot, stir until completely melted to form a uniform oil phase system, with a stirring speed of 30 - 50 r / min and a temperature of 70 - 80 °C;

[0056] Step 2, preparation of the water phase: Add deionized water to the water phase pot, slowly stir and add low-temperature xanthan gum, then add sucrose, a maintaining agent, a regulating agent, and a strengthening agent, and continue to stir until all components are fully dissolved to obtain a uniform water phase, with a stirring speed of 20 - 40 r / min;

[0057] Step 3, emulsification: Slowly add the oil phase to the water phase pot, start high-speed stirring until the oil phase and the water phase are fully emulsified to form a stable emulsion, with a stirring speed of 1000 - 1500 r / min;

[0058] Step 4, cooling: After emulsification is completed, stop high-speed stirring. When the emulsion cools down to 40 - 45 °C, add Candida fermented lipids and stir until they are uniformly dispersed in the emulsion;

[0059] Step 5, homogenization: Transfer the emulsion to a homogenizer and homogenize to refine the emulsion particles, with the pressure controlled at 15 - 25 MPa.

[0060] Examples:

[0061] Example 1: Basic moisturizing type

[0062] Formulation composition:

[0063] 10.0% of refined lanolin;

[0064] 3.5% of Candida fermented lipids;

[0065] 3.8% of a maintaining agent;

[0066] 2.0% of glycerol linolenate;

[0067] 4.5% of polyglyceryl-9 distearate;

[0068] 6.0% of a regulating agent;

[0069] 3.0% of sucrose;

[0070] 1.5% enhancer;

[0071] 0.3% low-temperature xanthan gum;

[0072] Make up deionized water to 100%.

[0073] Preparation process:

[0074] Step 1, preparation of oil phase: Add refined lanolin, glycerol linolenate, and polyglycerol-6 distearate to the oil phase pot, heat up to 70±2°C, and stir at 500 rpm for 15 min until completely melted;

[0075] Step 2, preparation of water phase: Add low-temperature xanthan gum to deionized water, disperse at 2000 rpm for 10 min until there are no particles, then add sucrose, regulator, and enhancer in sequence, maintain at 65±2°C, and stir for 20 min until dissolved;

[0076] Step 3, emulsification: Slowly inject the oil phase into the water phase, start high-speed shear emulsification at 12000 rpm for 25 min, and keep the temperature at 65°C;

[0077] Step 4, cooling: Stop shearing, cool down to 40°C at a rate of 2°C / min, add Candida fermented lipids, and stir at 800 rpm for 15 min;

[0078] Step 5, homogenization: Transfer the emulsion to a high-pressure homogenizer, homogenize 3 times at a pressure of 50 MPa, and the outlet temperature ≤ 35°C.

[0079] Example 2: Barrier repair enhanced type

[0080] Formulation composition:

[0081] 12.0% refined lanolin;

[0082] 4.0% Candida fermented lipids;

[0083] 4.2% maintainer;

[0084] 2.5% glycerol linolenate;

[0085] 5.0% polyglycerol-9 distearate;

[0086] 5.5% regulator;

[0087] 5.0% sucrose;

[0088] 1.8% enhancer;

[0089] 0.5% low-temperature xanthan gum;

[0090] Make up deionized water to 100%.

[0091] Preparation process:

[0092] Step 1, preparation of the oil phase: Add refined lanolin, glyceryl linolenate, and polyglyceryl-6 distearate to the oil phase pot, heat up to 72 ± 1 °C, and stir at 600 rpm for 20 min until completely melted;

[0093] Step 2, preparation of the water phase: Add low-temperature xanthan gum to deionized water. After the low-temperature xanthan gum is dispersed, add sucrose and the eutectic agent, heat up to 70 °C, and stir for 25 min;

[0094] Step 3, emulsification: Slowly inject the oil phase into the water phase, and use two-stage shearing. The first stage: 13000 rpm × 15 min, the second stage: 8000 rpm × 10 min;

[0095] Step 4, cooling: When the temperature is lowered to 45 °C, add Candida fermented lipids, and cooperate with ultrasonic wave-assisted dispersion, with a frequency of 40 kHz and a power of 200 W;

[0096] Step 5, homogenization: Increase the homogenization pressure to 60 MPa and circulate 4 times to ensure that the particle size D90 ≤ 150 nm.

[0097] Example 3: Low-temperature stability type

[0098] Formulation composition:

[0099] 8.0% of refined lanolin;

[0100] 3.0% of Candida fermented lipids;

[0101] 3.5% of the maintenance agent;

[0102] 1.8% of glyceryl linolenate;

[0103] 4.8% of polyglyceryl-9 distearate;

[0104] 7.0% of the regulator;

[0105] 2.5% of sucrose;

[0106] 1.2% of the enhancer;

[0107] 0.4% of low-temperature xanthan gum;

[0108] Make up deionized water to 100%.

[0109] Preparation process:

[0110] Step 1, preparation of the oil phase: The melting temperature of the oil phase is 68 °C, stir at 800 rpm, and keep warm for 10 min after melting;

[0111] Step 2: Preparation of the aqueous phase. Vacuum dispersion (-0.08 MPa) is used to prevent xanthan gum from agglomerating, and the dissolution temperature is 60°C.

[0112] Step 3: Emulsification. After the oil phase is added to the aqueous phase, it is first sheared at 10,000 rpm for 10 min, and then switched to 15,000 rpm for 15 min.

[0113] Step 4: Cooling. When the temperature is lowered to 42°C, Candida fermented lipids are added, and a pulsed electric field (1.5 kV / cm, 50 Hz) is applied simultaneously to promote molecular orientation.

[0114] Step 5: Homogenization. Two-stage homogenization is adopted. The first stage: 30 MPa × 2 times, the second stage: 70 MPa × 2 times.

[0115] To better understand the present invention, the present invention will be described in detail below in conjunction with specific embodiments.

[0116] The process parameters of Examples 1-3 are as follows in the table:

[0117] Process steps Example 1 Example 2 Example 3 Oil phase melting temperature 70±2℃ 72±1℃ 68℃ Emulsification shear rate 12000 rpm 13000 → 8000 rpm 10000 → 15000 rpm Cooling rate 2 °C / min 1.5 °C / min 2.5 °C / min Homogenization pressure 50 MPa × 3 60 MPa × 4 30 → 70 MPa × 2 Special process None Ultrasonic dispersion Pulsed electric field assistance

[0118] Comparative examples:

[0119] Comparative example 1: Ordinary lanolin replaces refined lanolin (corresponding to Example 1)

[0120] Adjustment content: Replace the refined lanolin (δ = 17.8) in Example 1 with industrial-grade lanolin (δ = 18.9), and other components and processes remain unchanged.

[0121] Comparative example 2: Excessive addition of sucrose (corresponding to Example 2)

[0122] Adjustment content: In Example 2 (barrier repair type), increase the sucrose addition amount to 7% (exceeding the design upper limit by 5%), and other components are reduced proportionally.

[0123] Comparative example 3: Cancel the electric field orientation process (corresponding to Example 3)

[0124] Adjustment content: In Example 3 (low-temperature stability type), remove the pulsed electric field assistance step, and other conditions remain unchanged.

[0125] Experimental design: One-to-one verification of examples and comparative examples

[0126] Experiment 1: Influence of lanolin type on liquid crystal compatibility

[0127] Control group: Example 1 is compared with Comparative example 1

[0128] Purpose: Verify the necessity of refined lanolin (δ = 17.8) for the system compatibility.

[0129] Experimental method:

[0130] The samples of Example 1 (containing 10% refined lanolin) and Comparative Example 1 (containing 10% industrial-grade lanolin) were respectively placed in a constant temperature oven at -25°C for pretreatment for 6 hours, and then the following tests were carried out:

[0131] 1. Determination of Hildebrand parameter: Using a Hansen solubility parameter analyzer (HSPiP v5.0), the mixture δ_mix was determined by the swelling method. Three groups of parallel samples were taken and equilibrated at 25°C for 24 hours before testing;

[0132] 2. Observation with a polarized light microscope: 0.5 mL of the sample was dropped onto a glass slide, covered with a coverslip, and immediately transferred to a cryo-stage (-25°C). The phase structure was observed under crossed polarized light using an Olympus BX53-P polarized light microscope (magnification 400×), and 10 images were taken for each sample;

[0133] 3. Determination of TEWL value: Using a CM825 probe, attached to the surface of an artificial skin model at -25°C, and the water loss amount within 6 hours was continuously recorded. Each group was repeated 5 times.

[0134] The experimental data are as follows in the table:

[0135]

[0136] Experimental summary: Although the δ_mix of refined lanolin is stable within the theoretical range (17.5 - 18.5), the deviation of the δ value of industrial-grade lanolin leads to irreversible phase separation in the system, which is basically consistent with the prediction of the Hildebrand model. However, the high discreteness of some TEWL data (such as 18.5 - 19.0 g / (m 2 ·h) in Comparative Example 1) indicates that the distribution uniformity of the branched-chain fatty acids in lanolin may have a non-linear effect on the actual performance - the random fluctuation of the isomer ratio in industrial-grade lanolin may make the barrier performance in local areas briefly approach the level of Example 1, but the overall is still significantly deteriorated.

[0137] It should be noted that the proportion of the lamellar phase observed in the POM images (35 - 48% in Comparative Example 1) is not strictly linearly correlated with the TEWL value, suggesting that the random distribution of phase interface defects may exacerbate the unpredictability of water loss. This phenomenon indicates that in future research, it is necessary to introduce mesoscale simulations (such as dissipative particle dynamics) to analyze the complex mapping relationship between the microscopic phase state and the macroscopic performance.

[0138] Experiment 2: Effect of sucrose addition amount on low-temperature stability

[0139] Control group: Example 2 vs. Comparative Example 2

[0140] Objective: To verify the scientificity of the upper limit of sucrose addition (5%).

[0141] Experimental method: Samples of Example 2 (containing 5% sucrose) and Comparative Example 2 (containing 7% sucrose) were respectively subjected to low-temperature stability tests:

[0142] 1. Freeze-thaw cycle: The samples were frozen at -20°C for 12 hours, then thawed at 25°C for 12 hours, and the cycle was repeated 5 times. Visual inspection was carried out for delamination and crystallization phenomena, and a laser particle size analyzer (Malvern Mastersizer 3000) was used to detect changes in particle size;

[0143] 2. DSC detection: 10 mg of the sample was sealed in an aluminum crucible and heated from -30°C to 20°C at a rate of 5°C / min, and the positions and areas of the endothermic / exothermic peaks were recorded. Special attention was paid to whether a sucrose crystallization peak appeared in the range of -15 to -8°C;

[0144] 3. Rheological recovery rate: After the samples were left standing at -25°C for 6 hours, the viscosity at 25°C (shear rate 10 s -1 ) was immediately measured using a Brookfield DV3T rheometer (rotor CP-40), and the recovery rate (the ratio to the initial viscosity) was calculated.

[0145] The experimental data are shown in the following table:

[0146]

[0147] Experimental summary: Although excessive sucrose (7%) generally causes crystallization and delamination, a few abnormal data points imply a non-linear effect in the critical state - when the local molar ratio of sucrose to trehalose accidentally drops below 1:3, the transient stability of the hydrogen bond network may mask the risk of excessive addition. This instability is closely related to the temperature dependence of the diffusion rate of sucrose molecules: during the freezing process at -20°C, solute concentration gradients are formed in some regions due to the extrusion of ice crystal growth, thus forming "pseudo-stable" micro-regions.

[0148] The fluctuations in the rheological recovery rate (such as up to 89% in a certain test of Comparative Example 2) further indicate that the dynamic shear history may temporarily repair the network structure damaged by sucrose crystallization, but the long-term stability still deteriorates irreversibly. This phenomenon suggests that in the future, in-situ monitoring techniques (such as low-temperature Raman spectroscopy) need to be developed to track the interaction kinetics of sucrose - eutectic agents in real time, so as to analyze the molecular competition behavior behind the transient stability mechanism.

[0149] It is worth noting that an abnormal absence of a crystallization peak detected by DSC may be related to trace moisture residues during sample preparation (accelerating the formation of the amorphous state), but this instead exposes the potential challenges of environmental humidity control in industrial production - minor moisture fluctuations may amplify the formulation sensitivity, resulting in unpredictable deviations between laboratory data and mass production performance.

[0150] Experiment 3: The effect of electric field orientation on molecular order

[0151] Control group: Example 3 is compared with Comparative Example 3

[0152] Purpose: To verify the regulatory effect of pulsed electric field on the orientation of liquid crystal molecules.

[0153] Experimental method: Compare the molecular order and barrier performance of the samples of Example 3 (with pulsed electric field treatment) and Comparative Example 3 (without electric field treatment):

[0154] 1. X-ray diffraction (XRD): Use a Rigaku SmartLab diffractometer (Cu-Kα radiation, ), scan angle 2θ = 1 - 10°, and measure the full width at half maximum (FWHM) of the diffraction peak of the (100) crystal plane. Each sample is tested 3 times and the average value is taken;

[0155] 2. Differential scanning calorimetry (DSC): Take 5 mg of the sample, heat it from -30 °C to 20 °C at a rate of 5 °C / min, and record the phase change enthalpy ΔH at -18 °C (TA Instruments Q200);

[0156] 3. Clinical evaluation: 30 children aged 5 - 8 years are divided into two groups and use the corresponding samples every morning and evening. After 14 days, a dermatologist blindly evaluates the chapping index (0 - 3 points, 0 = no chapping).

[0157] The experimental data are as follows in the table:

[0158]

[0159] Experimental summary: Electric field treatment significantly reduced the XRD full width at half maximum (a decrease of up to 34%), but the occasional wide peak data suggests that molecular orientation may be extremely sensitive to minor perturbations of electric field parameters - millisecond-level deviations in pulse width or frequency are sufficient to disrupt the oriented arrangement in some regions. This vulnerability is related to the dynamic relaxation characteristics of the liquid crystal phase: when the electric field is removed, some molecular chains retract due to the drive of entropy increase, resulting in a non-uniform distribution of order.

[0160] In clinical data, although the overall performance of Example 3 was excellent (crack index 0.3 - 0.4), some children had a high score of 1.2, which may be related to the difference in the thickness of the skin cutin layer or the compliance of use. It is worth noting that the ΔH value (7.8 J / g) of these abnormal cases was still significantly lower than the average value of Comparative Example 3, indicating that the macroscopic advantage of molecular arrangement could not completely eliminate individual physiological differences.

[0161] In DSC data, the "pseudo-optimal value" with a ΔH = 8.9 J / g in a certain instance of Comparative Example 3 was actually the result of accidental ordering of the local mesophase. This random fluctuation phenomenon was consistent with the thermodynamic fluctuation theory, but it also exposed the limitation of the traditional detection method - point sampling might mask the spatial heterogeneity of the system. In the future, it is necessary to combine micro-area infrared imaging to analyze the regulation law of the electric field treatment on the order degree distribution at the mesoscopic scale.

[0162] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principle and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A special antifreeze skin care essence for children, characterized in that: The following raw materials are included in percentage by mass: 8.0% to 12.0% refined lanolin; 3.0% to 4.0% Candida fermented lipids; 3.5% to 4.2% maintenance agent; 1.5% to 2.5% linolenic acid glyceride; 4.5% to 5.5% polyglyceryl-9 distearate; 5.0% to 7.0% of regulator; 2.0% to 5.0% sucrose; 1.2% to 1.8% enhancer; 0.3% to 0.5% low-temperature xanthan gum; 57.5% to 71% deionized water.

2. The antifreeze skin care essence for children according to claim 1, characterized in that: The maintaining agent is one of phytosphingosine or ceramide IIIB complex, the regulating agent is one of trimethylglycine or trehalose cocrystal, and the enhancing agent is one of hydrogenated lecithin or cholesterol complex.

3. The antifreeze skin care essence for children according to claim 1, characterized in that: The molar ratio of sucrose to the regulating agent is ≤1:

3.

4. The antifreeze skin care essence for children according to claim 1, characterized in that: The iodine value content of the linolenic acid glyceride is ≥160gl2 / 100g.

5. The antifreeze skin care essence for children according to claim 1, characterized in that: The refined lanolin contains 45% to 50% of branched-chain fatty acids and has an iodine value of 18 to 25 gl2 / 100g.

6. A process for producing a special antifreeze skin care essence for children, applied to the special antifreeze skin care essence for children as claimed in any one of claims 1 to 5, characterized in that: The following steps are involved: Step 1: preparing the oil phase, adding refined lanolin, linolenic acid glyceryl ester and polyglyceryl-9 distearate into the oil phase pot, stirring until completely melted to form a uniform oil phase system; Step 2: Prepare the aqueous phase. Add deionized water to the aqueous phase pot, slowly stir and add low-temperature xanthan gum, then add sucrose, a maintaining agent, a regulating agent and an enhancing agent, and continue stirring until all ingredients are fully dissolved to obtain a uniform aqueous phase. Step 3: Emulsification: slowly add the oil phase into the water phase pot and stir at high speed until the oil phase and water phase are fully emulsified to form a stable emulsion; Step 4: Cooling down and cooling. After emulsification is completed, stop high-speed stirring. When the emulsion is cooled to 40-45°C, add Candida fermented lipid and stir until it is evenly dispersed in the emulsion; Step 5: Homogenize. Transfer the emulsion to a homogenizer to homogenize and refine the emulsion particles.

7. The process for producing a special antifreeze skin care essence for children according to claim 6, characterized in that: The stirring speed of the oil phase preparation is 30-50 r / min and the temperature is 70-80°C.

8. The process for producing a special antifreeze skin care essence for children according to claim 6, characterized in that: The stirring speed of the aqueous phase preparation is 20-40 r / min.

9. The process for producing a special antifreeze skin care essence for children according to claim 6, characterized in that: The stirring speed of the emulsification is 1000-1500 r / min.

10. The process for producing a special antifreeze skin care essence for children according to claim 6, characterized in that: The homogenization pressure is controlled at 15-25 MPa.

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