Tumor electric field treatment system and method performed thereby

Abstract

The invention provides a tumor electric field treatment system, which comprises an electrode plate, the electrode plate comprises a plurality of electrode units and an encryption unit, the encryption unit and the plurality of electrode units are connected to the same ground wire, and the encryption unit stores encryption information corresponding to the plurality of electrode units; the adapter is connected between the electrode slice and the electric field generator, the adapter is configured to transmit an alternating current electric signal generated by the electric field generator to the electrode unit of the electrode slice, the adapter is coupled to the encryption unit, and the encryption unit is configured to encrypt the alternating current electric signal generated by the electric field generator to the electrode unit of the electrode slice. And a control unit configured to generate control information for the electrode plate in response to the encryption information acquired from the encryption unit.

Description

Technical Field

[0001] The present disclosure relates to the technical field of medical devices, and in particular to a tumor electric field therapy system and a method performed by the tumor electric field therapy system. Background Art

[0002] At present, the main treatments for tumors include surgery, radiotherapy, chemotherapy, etc., but they all have corresponding disadvantages. For example, radiotherapy and chemotherapy can produce side effects and kill normal cells. Using electric fields to treat tumors is also one of the current research and development frontiers. Tumor electric field therapy is a tumor treatment method that uses an electric field generator to generate a low-intensity, medium-high frequency, alternating electric field to interfere with the mitotic process of tumor cells. Studies have shown that electric field therapy is effective in treating glioblastoma, non-small cell lung cancer, malignant pleural mesothelioma and other diseases. The electric field applied by this treatment method can affect the aggregation of microtubule proteins, prevent spindle formation, inhibit the mitotic process, and induce apoptosis of cancer cells.

[0003] The tumor treatment electric field needs to be applied to the patient's body through a carrier. The common carrier is an electrode sheet. The electrode sheet is first applied to the target area on the patient's body, and then the AC electric field is applied to the electrode sheet to act on the target area. Therefore, the quality and application effect of the electrode sheet directly affect the treatment effect. The electrode sheet includes a number of electrode units, and the electrode unit is generally composed of ceramic sheets. Ceramic sheets are hard and cannot be bent, and cannot be well applied to the target area. In order to better apply, fillers are required between the ceramic sheet and the target area. Therefore, soft materials need to be added to the surface of the ceramic sheet.

[0004] In order to better apply the patch, a soft material for pasting can be provided on the electrode unit. After being heated and used for some time, the pasting effect of the patch material will decrease, resulting in the electrode unit being unable to be tightly adhered, thereby affecting the treatment effect. Therefore, the use time of the electrode unit needs to be controlled. The electrode unit needs to be replaced after each period of use. In addition, as the devices on the electrode sheet change over time, there will be problems with updates or discontinuation of production. Since the characteristics of devices of different generations are different, errors in temperature acquisition will occur, which will affect the treatment effect. In addition, the electrode unit needs to be anti-counterfeited to prevent patients from using counterfeit and inferior electrode units, resulting in poor treatment effects or more serious injuries. Summary of the invention

[0005] According to one aspect of the present disclosure, there is provided a tumor electric field therapy system, comprising: an electrode sheet, the electrode sheet comprising a plurality of electrode units and an encryption unit, the encryption unit being connected to the same ground line as the plurality of electrode units, wherein the encryption unit stores encryption information corresponding to the plurality of electrode units; and an adapter connected between the electrode sheet and an electric field generator, the adapter being configured to transmit an alternating current signal generated by the electric field generator to the electrode units of the electrode sheet, wherein the adapter is coupled to the encryption unit and configured to generate control information for the electrode sheet in response to the encryption information obtained from the encryption unit.

[0006] In some embodiments, the adapter is coupled to the encryption unit via at least one communication line, and obtains the encryption information via the at least one communication line.

[0007] In some embodiments, the adapter is also configured to: close at least one switch connected to the ground wire so that the adapter is electrically connected to the electrode unit and the encryption unit in the electrode sheet; and communicate with the encryption unit to obtain the encryption information stored in the encryption unit.

[0008] In some embodiments, the encrypted information includes at least one of the following items related to the electrode sheet: a source identifier, an electrode sheet status parameter, and an electrode sheet configuration parameter.

[0009] In some embodiments, the electrode sheet configuration parameters include at least one of an electrode unit type and a diode type.

[0010] In some embodiments, the encrypted information obtained includes the electrode unit type, wherein generating control information for the electrode sheet in response to the encrypted information obtained from the encryption unit includes: determining the number of electrode units corresponding to the electrode unit type; obtaining a predetermined number of electrode unit temperatures collected by a temperature detection unit; and generating a fault signal for the electrode sheet in response to determining that the number of the predetermined number of electrode unit temperatures that meets a preset temperature range is different from the number of electrode units.

[0011] In some embodiments, the obtained encrypted information includes the diode type, wherein generating control information for the electrode sheet in response to the encrypted information obtained from the encryption unit includes: determining the forward voltage drop of the diode used by the electrode sheet based on the diode type; and determining the temperature of the electrode unit in the electrode sheet based on the forward voltage drop.

[0012] In some embodiments, the electrode pad status parameter includes at least one of an electrode pad production date, an electrode pad usage status, and an electrode pad activation date.

[0013] In some embodiments, the encrypted information obtained includes the production date of the electrode sheet, wherein the control information for the electrode sheet generated in response to the encrypted information obtained from the encryption unit includes: obtaining the time of the real-time clock RTC of the adapter; determining the production length of the electrode sheet based on the RTC time and the production date of the electrode sheet; and generating a fault signal for the electrode sheet in response to the production length of the electrode sheet exceeding a predetermined production period.

[0014] In some embodiments, the encrypted information obtained includes an electrode sheet activation date of the electrode sheet, wherein generating control information for the electrode sheet in response to the encrypted information obtained from the encryption unit includes: obtaining the time of the real-time clock RTC of the adapter; determining the length of time the electrode sheet has been used based on the time of the RTC and the electrode sheet activation date; and generating the fault signal for the electrode sheet in response to the length of time the electrode sheet has been used exceeding a predetermined usage period.

[0015] In some embodiments, the obtained encrypted information includes the usage status of the electrode sheet, wherein generating control information for the electrode sheet in response to the encrypted information obtained from the encryption unit includes: generating the fault signal for the electrode sheet in response to the electrode sheet usage status indicating that the electrode sheet has been used.

[0016] In some embodiments, the encrypted information includes the source identifier, wherein generating control information for the electrode sheet in response to the encrypted information obtained from the encryption unit includes: generating the fault signal in response to the source identifier being different from a predetermined source identifier.

[0017] In some embodiments, generating control information for the electrode sheet in response to the encrypted information obtained from the encryption unit includes generating a fault signal in response to the encrypted information being invalid information.

[0018] In some embodiments, the adapter is further configured to: encrypt the initial parameters of the encryption information using a key, and write the encrypted initial parameters of the encryption information into the encryption unit.

[0019] In some embodiments, the adapter is further configured to: encrypt the update parameters of the encryption information using a key, and write the encrypted update parameters of the encryption information into the encryption unit to replace the initial parameters.

[0020] According to another aspect of the present disclosure, a method performed by a tumor electric field therapy system is also provided, wherein the tumor electric field therapy system is the tumor electric field therapy system as described above, and the method includes: obtaining encryption information stored in the encryption unit; and generating control information for the electrode sheet in response to the encryption information obtained from the encryption unit.

[0021] These and other aspects of the disclosure will be apparent from and elucidated with reference to the embodiments described hereinafter. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Further details, features and advantages of the present disclosure are disclosed in the following description of example embodiments in conjunction with the accompanying drawings, in which:

[0023] Figure 1 An exemplary block diagram of a tumor electric treatment field system according to an embodiment of the present disclosure is shown;

[0024] Figure 2 for Figure 1 A schematic diagram of the electrical connection between the adapter and the encryption unit shown;

[0025] Figure 3 Another exemplary block diagram of a tumor electric treatment field system according to an embodiment of the present disclosure is shown;

[0026] Figure 4 for Figure 3 A schematic diagram of a temperature detection unit shown;

[0027] Figure 5 A schematic block diagram showing the circuit connection of an electrode sheet and an adapter in a tumor electric field treatment system according to an embodiment of the present disclosure is shown;

[0028] Figure 6 A schematic block diagram showing circuit connections of another electrode sheet and an adapter of a tumor electric field treatment system according to an embodiment of the present disclosure is shown;

[0029] Figure 7 A schematic block diagram showing circuit connections of another electrode sheet and an adapter of a tumor electric field treatment system according to an embodiment of the present disclosure is shown;

[0030] Figure 8 is a schematic diagram of the internal structure of an adapter according to an embodiment of the present disclosure;

[0031] Fig. 9 A schematic diagram of a tumor electric field treatment system according to the present invention is shown;

[0032] Fig.10An exemplary flow chart of a method performed by a tumor treating field system according to an embodiment of the present disclosure is shown. DETAILED DESCRIPTION

[0033] Figure 1 An exemplary block diagram of a tumor treatment field system according to an embodiment of the present disclosure is shown.

[0034] like Figure 1 As shown, the tumor electric field treatment system 100 may include an electrode sheet 110 and an adapter 120 .

[0035] The electrode sheet 110 may include an encryption unit 111 and a plurality of electrode units 112. The encryption unit 111 and the plurality of electrode units 112 are connected to the same ground line 113. The encryption unit 111 stores encryption information corresponding to the plurality of electrode units 112.

[0036] The adapter 120 is connected between the electrode sheet 110 and the electric field generator 130. The adapter 120 is configured to transmit the alternating current signal generated by the electric field generator 130 to the electrode unit 112 through the alternating current signal line.

[0037] The adapter 120 is coupled to the encryption unit 111 and is configured to generate control information for the electrode sheet 110 in response to the encryption information obtained from the encryption unit 111. The control information may include a fault signal indicating that the electrode sheet 110 has a fault or any other information that can be used to control the electrode sheet 110, such as voltage, resistance, temperature, etc. measured for the electrode sheet 110.

[0038] By using the tumor electric field treatment system 100 provided by the present disclosure, the encrypted information related to the electrode unit 112 in the electrode sheet 110 can be obtained from the encryption unit 111 set on the electrode sheet 110, so as to obtain information related to the use of the electrode unit 112. The use of the electrode sheet 110 of the tumor electric field treatment system 100 is controlled by generating control information based on the obtained encrypted information, thereby improving the treatment effect of the tumor electric field treatment system 100. In addition, by configuring the encryption unit 111 and multiple electrode units 112 to be connected to the same ground line 113, an encryption unit 111 for storing information can be conveniently added to the circuit structure of the original electrode sheet 110. And it can be achieved that the encrypted information can be obtained at the same time when the electrode sheet 110 is enabled, so that the tumor electric field treatment system 100 can be disabled or new encrypted information can be written in the encryption unit 111 at any time according to the information indicated by the encrypted information before the electrode sheet 110 is enabled or during the use of the electrode sheet 110.

[0039] In some embodiments, the adapter 120 may generate a fault signal in response to the encrypted information obtained being invalid information. For example, if the communication between the adapter 120 and the encryption unit 111 fails or the communication fails, the encrypted information obtained may be empty information or meaningless garbled information, i.e., invalid information. In the case where the encrypted information obtained by the adapter 120 is invalid information, a fault signal may be generated to disable the tumor electric field treatment system 100. Using such a method, the electrode sheet 110 will only be enabled for treatment when the encrypted information is obtained and the encrypted information indicates that the electrode sheet 110 is valid, which can effectively prevent the use of invalid, expired or any other defective electrode sheet 110 during treatment.

[0040] In some embodiments, the adapter 120 can be coupled to the encryption unit 111 via at least one communication line, and obtain the encryption information via the at least one communication line.

[0041] Figure 2 An example of electrical connection between the adapter 120 and the encryption unit 201 is shown.

[0042] like Figure 2 As shown, the adapter 120 may include a decryption unit 202. The decryption unit 202 and the encryption unit 201 may be coupled via a communication line 203. The communication line 203 may be an I / O control line.

[0043] In some examples, the encryption unit 201 may be a memory, such as an erasable programmable read-only memory (EEPROM) or any other suitable type of memory. The decryption unit 202 may store a key, which can decrypt the encrypted information stored in the encryption unit 201, thereby parsing the acquired encrypted information.

[0044] For example, the encryption chip GX2431 can be used as the encryption unit 201. In this case, only a single bus communication method is needed to realize the communication between the adapter 120 and the encryption unit 201. In this way, only a core wire needs to be added between the adapter 120 and the electrode sheet 110 to realize the data reading and writing function. Figure 2 As shown, in order to realize data reading and writing between the decryption unit 202 and the encryption unit 201 , it is also necessary to configure the decryption unit 202 with a power supply VCC and a pull-up resistor 204 connected between the power supply VCC and the communication line 203 . Figure 2 The configuration scheme of the three-core wires for the decryption unit 202 is shown in FIG. 2 , wherein the three-core wires refer to a power line, a ground line and a communication line 203 .

[0045] It is understandable that, according to actual conditions, other types of storage chips may also be used as the encryption unit 201. For example, a 4-core wire configuration scheme, namely a power line, a ground line and two communication lines 203, may also be used.

[0046] Return to reference Figure 1 In some embodiments, the adapter 120 is also configured to: close at least one switch connected to the ground wire so that the adapter 120 is electrically connected to the electrode unit 112 and the encryption unit 111 in the electrode sheet 110, and communicate with the encryption unit 111 to obtain the encryption information stored in the encryption unit 111.

[0047] Figure 3 Another exemplary block diagram of a tumor treating field system according to an embodiment of the present disclosure is shown.

[0048] like Figure 3 As shown, the tumor electric field treatment system 300 may include an electrode sheet 310 , an adapter 320 , and an electric field generator 330 .

[0049] The electrode sheet 310 may include an encryption unit 311 and a plurality of electrode units 312. Figure 3 For the convenience of description, only two electrode units 312 are shown. Figure 3 As shown, each electrode unit 312 is grounded via a switch 302 .

[0050] The adapter 320 may include a control unit 322 and a decryption unit 321. The decryption unit 321 is coupled to the encryption unit 311 via the communication line 301. The control unit 322 may be used to control the on and off of each switch 302. When the control unit 322 controls all switches 302 to be turned on, the electrical circuit where the electrode unit 312 is located and the electrical circuit where the encryption unit 311 is located may be turned on at the same time. In other words, the encrypted information related to the electrode unit 312 stored in the encryption unit 311 may be obtained while the electrode unit 312 is enabled. The tumor electric field therapy system 300 of the embodiment of the present disclosure may obtain information related to the electrode unit 312 while using the electrode unit 312 while minimizing the additional circuit design, thereby enabling additional control over the use of the electrode unit 312.

[0051] The electric field generator 330 may be used to generate an alternating current signal and transmit the alternating current signal to the electrode unit 312 connected in series with the alternating current signal line via the adapter 320 . Figure 3 The specific circuit connection between the electric field generator 330 and the electrode unit 312 is not shown. Those skilled in the art can design the circuit between the electric field generator 330 and the electrode unit 312 according to actual conditions.

[0052] In some embodiments, the encrypted information stored in the encryption unit 311 may include at least one of the following information related to the electrode sheet 310: source identification, electrode sheet state parameters, and electrode sheet configuration parameters.

[0053] Before the electrode sheet 310 leaves the factory, the initial parameters of the encrypted information can be written into the encryption unit 311 of the electrode sheet 310. In some implementations, the initial parameters of the encryption unit 311 can be encrypted using a key, and the encrypted initial parameters can be written into the encryption unit 311, or the adapter 320 can implement the encryption and writing of the initial parameters. Furthermore, during the use of the electrode sheet 310, the encrypted information in the encryption unit 311 can be updated according to actual conditions. For example, the adapter 320 can encrypt the update parameters of the encrypted information using a key, and write the encrypted update parameters into the encryption unit 311 to replace the previously stored content.

[0054] The source identifier may indicate the source of the electrode sheet 310, such as the company code that produces and sells the electrode unit 312. By obtaining the source identifier stored in the encryption unit 311, it can be determined whether the electrode sheet 310 is produced by a qualified manufacturer. In some embodiments, the control information of the electrode sheet 310 generated by the adapter 320 in response to the obtained encrypted information may include a fault signal. The fault signal may be used to disable the electric field generator 330, thereby prohibiting the start-up of the tumor electric field treatment system 300. In some examples, when the encrypted information includes the source identifier, a fault signal may be generated in response to determining that the obtained source identifier is different from the source identifier preset in the adapter 320 or the electric field generator 330. For example, the obtained source identifier may be compared with each of at least one pre-stored preset source identifier. If the obtained source identifier is the same as a pre-stored preset source identifier, the source of the electrode sheet 310 may be considered to be reliable. Otherwise, it is considered that the electrode sheet 310 may be a counterfeit product, and therefore a fault signal will be generated to prohibit the use of the tumor electric field treatment system 300.

[0055] The electrode sheet configuration parameter may indicate the configuration of the electrode unit used in the electrode sheet 310. For example, the electrode sheet configuration parameter may be used to indicate the quantity, model, and other information of various electronic components used in the electrode sheet 310.

[0056] In some implementations, electrode sheet configuration parameters may include electrode unit type and diode type.

[0057] The electrode unit type can be used to indicate the number of electrode units 312 configured in the electrode sheet 310. For example, for different treatment purposes, an electrode sheet 310 configured with 9, 13 or 20 electrode units 312 can be used. Each electrode unit 312 can also be configured with a temperature detection unit (not shown), and the temperature detection unit (not shown) includes a temperature sensor (not shown), which can be a thermistor. The temperature sensor (not shown) can be used to monitor the temperature of the electrode unit 312 in real time, so as to monitor whether the electrode unit 312 is working normally. If it is detected that the temperature of the electrode unit 312 exceeds the predetermined temperature range in the adapter 320 or the electric field generator 330, it can be considered that the electrode sheet 310 has a fault. And send a fault signal to the host (i.e., the electric field generator 330) of the tumor electric field treatment system 300 to control the tumor electric field treatment system 300 to stop working.

[0058] The control unit 322 in the adapter 320 can be used to collect the temperature of the electrode unit 312. Since the adapter 320 needs to be compatible with the electrode sheet 310 having different numbers of electrode units 312, the number of temperatures collected by the adapter 320 needs to be compatible with all possible electrode sheets 310, that is, equal to the number of the maximum possible number of electrode units 312. For example, in the case where there is an electrode sheet 310 configured with 9, 13 or 20 electrode units 312, the control unit 322 of the adapter 320 needs to collect the temperatures of 20 electrode units 312. In this case, if only 9 of the 20 temperature values ​​collected by the adapter 320 are within the range, and the other 11 temperature values ​​are out of the range, it is difficult for the adapter 320 to distinguish whether such a collection result is due to the fact that only 9 electrode units 312 are configured in the electrode sheet 310, or due to the fact that 13 of the 20 electrode units 312 have damaged temperature sensors. Similarly, if only 13 of the 20 temperature values ​​collected by the adapter 320 are within the range and the other 7 temperature values ​​are out of the range, it is difficult for the adapter 320 to distinguish whether such collection results are due to the fact that only 13 electrode units 312 are configured in the electrode sheet 310 or due to the fact that 7 of the 20 electrode units 312 have damaged temperature sensors. In order to avoid errors in the adapter 320 when determining whether the temperature on the electrode unit 312 is normal, the number of electrode units 312 can be indicated by configuring the electrode unit type in the encrypted information.

[0059] In some examples, the adapter 320 can determine the number of electrode units 312 corresponding to the electrode unit type, obtain the temperatures of the predetermined number of electrode units 312 collected by the temperature detection unit (not shown), and generate a fault signal for the electrode sheet 310 in response to determining that the number of the predetermined number of electrode unit 312 temperatures that meet the preset temperature range is different from the number of electrode units 312, thereby generating control information for the electrode sheet 310 in response to the encrypted information obtained from the encryption unit 311. In this way, the adapter 320 can accurately determine whether the currently collected temperature indicates that the electrode sheet 310 is abnormal.

[0060] Figure 4 An example of a temperature detection unit according to an embodiment of the present disclosure is shown.

[0061] like Figure 4 As shown, the temperature detection unit (not numbered) provided on the electrode unit 312 may include a thermistor Rt and a diode D1. The thermistor Rt is connected to the power source VCC via a pull-up resistor Rp.

[0062] In some examples, the temperature and resistance of thermistor Rt satisfy equation (1):

[0063] Temp=1 / (ln(Rt / RT) / B+1 / T2)-273.15 (1)

[0064] Among them, Rt is the resistance value of thermistor Rt at the current Temp temperature, RT is the nominal resistance value of thermistor Rt at room temperature T2 (298.15K, i.e. 25°C), and B is the parameter of thermistor Rt (such as 3380).

[0065] When the power supply VCC, the resistance of the pull-up resistor Rp, and the conduction voltage drop of the diode are known, the current resistance of the thermistor Rt can be calculated by measuring the voltage value at Vadc, and the current temperature Temp of the thermistor Rt can be calculated based on formula (1). Since the temperature detection unit (unnumbered) including the thermistor Rt is arranged on the electrode unit 312, the current temperature of the thermistor Rt is equivalent to the current temperature of the electrode unit 312.

[0066] based on Figure 4 The circuit structure shown in FIG. 1 can calculate the resistance value of thermistor Rt based on formula (2):

[0067] Rt=(Vadc-Vd)*Rp / (VCC-Vadc) (2)

[0068] Among them, Vadc is the measured voltage value, Vd is the forward voltage drop of the diode, Rp is the resistance value of the pull-up resistor, and VCC is the power supply voltage.

[0069] When the VCC voltage is 3.3V, the pull-up resistor Rp is 10KΩ, and the on-state voltage drop of the diode model used is 0.4V, the resistance value of the thermistor Rt can be calculated by formula (3):

[0070] Rt=(Vadc-0.4)*10 / (3.3-Vadc) (3)

[0071] When Vadc is 1.75V, Rt = 8.71KΩ, and formula (1) converts Temp = 28.68℃;

[0072] When Vadc is 1.76V, Rt = 8.83KΩ, and formula (1) converts Temp = 28.31℃;

[0073] When Vadc is 1.77V, Rt = 8.95KΩ, and formula (1) converts Temp = 27.93℃;

[0074] When Vadc is 1.78V, Rt = 9.08KΩ, and formula (1) converts Temp = 27.56℃;

[0075] When Vadc is 1.79V, Rt = 9.21KΩ, and formula (1) converts Temp = 27.19℃;

[0076] When Vadc is 1.80V, Rt = 9.33KΩ, and formula (1) converts Temp = 26.83℃;

[0077] When Vadc is 1.81V, Rt = 9.46KΩ, and formula (1) converts Temp = 26.46℃;

[0078] When Vadc is 1.82V, Rt = 9.59KΩ, and formula (1) converts Temp = 26.09℃;

[0079] When Vadc is 1.83V, Rt = 9.73KΩ, and formula (1) converts Temp = 25.73℃;

[0080] When Vadc is 1.84V, Rt = 9.86KΩ, and formula (1) converts Temp = 25.36℃;

[0081] When Vadc is 1.85V, Rt = 10KΩ, and formula (1) converts to Temp = 25℃;

[0082] When Vadc is 1.86V, Rt = 10.14KΩ, and formula (1) converts Temp = 24.64℃;

[0083] When Vadc is 1.87V, Rt = 10.28KΩ, and formula (1) converts Temp = 24.28℃;

[0084] When Vadc is 1.88V, Rt = 10.42KΩ, and formula (1) converts Temp = 23.92℃;

[0085] When Vadc is 1.89V, Rt = 10.57KΩ, and formula (1) converts Temp = 23.56℃;

[0086] When Vadc is 1.90V, Rt = 10.71KΩ, and formula (1) converts Temp = 23.20℃;

[0087] According to the above formula, the greater the resistance of thermistor Rt, the lower the temperature. At the same time, when the control unit 322 calibrates Vadc to 1.85V, the corresponding temperature is 25°C. The difference in Vadc is 0.01V, and the difference in the temperature of thermistor Rt is about 0.36°C.

[0088] If the diode type of a batch of electrode sheets 310 is changed for some reason, the diode conduction voltage drop changes to 0.3V. Therefore, the conversion formula of thermistor Rt should be modified to:

[0089] Rt=(Vadc-0.3)*10 / (3.3-Vadc) (4)

[0090] When the ambient temperature is 25°C, the resistance of the thermistor Rt is 10KΩ, and the Vadc collected by the control unit 322 is 1.80V (converted according to formula (4)). However, the control unit 322 cannot recognize the current information of the electrode sheet 310, and still converts it according to formula (3). According to Vadc=1.80V, the resistance of the thermistor Rt calculated by the control unit 322 through formula (3) is 9.33KΩ, and the temperature of the thermistor Rt is further converted to 26.83°C through formula (1), which is about 1.83°C higher than the actual temperature (25°C);

[0091] If the diode type of a batch of electrode sheets 310 is changed for some reason, the diode conduction voltage drop changes to 0.5V. Therefore, the conversion formula of thermistor Rt should be modified to:

[0092] Rt=(Vadc-0.5)*10 / (3.3-Vadc) (5)

[0093] When the ambient temperature is 25°C, the resistance of the thermistor Rt is 10KΩ, and the Vadc collected by the control unit 322 is 1.90V (converted according to formula (5)). However, the control unit 322 cannot recognize the current information of the electrode sheet 310, and still converts it according to formula (3). According to Vadc=1.90V, the resistance of the thermistor Rt calculated by the control unit 322 through formula (3) is 10.71KΩ, and the temperature of the thermistor Rt is further converted to 23.20°C through formula (1), which is about 1.80°C lower than the actual temperature (25°C).

[0094] If the diode type of a batch of electrode sheets 310 is changed for some reason, the diode conduction voltage drop changes to 0.2V. Therefore, the conversion formula of thermistor Rt should be modified to:

[0095] Rt=(Vadc-0.2)*10 / (3.3-Vadc) (6)

[0096] When the ambient temperature is 25°C, the resistance of the thermistor Rt is 10KΩ, and the Vadc collected by the control unit 322 is 1.75V (converted according to formula (6)). However, the control unit 322 cannot recognize the current information of the electrode sheet 310, and still converts it according to formula (3). According to Vadc=1.75V, the resistance of the thermistor Rt calculated by the control unit 322 through formula (3) is 8.71KΩ, and the temperature of the thermistor Rt is further converted to 28.68°C through formula (1), which is about 3.68°C higher than the actual temperature (25°C).

[0097] From the above, it can be seen that when the conduction voltage drop of diodes of different models differs by 0.1V, the temperature of the thermistor Rt differs by about 1.83°C. The error caused by the mismatch of models is 1.83 / 25=7.3%, which is more than 7 times the accuracy of the thermistor of 1%. When the actual temperature of the electrode unit 312 in the current electrode sheet 310 is 41°C, it will exceed the alarm temperature, and the system needs to shut down the electric field therapy to avoid burns. However, if the diode conduction voltage drop is 0.1V higher than the system conversion formula due to different diode models, resulting in the control unit 322 converting the collected voltage Vadc to a temperature of 39.2°C, the system will find it difficult to detect that the temperature exceeds the threshold. If the tumor electric field therapy system 300 continues to be used for a period of time, the skin will be burned. Similarly, if the actual temperature of the electrode unit 312 of the current electrode sheet 310 is 39.2°C, and due to the different diode models, it is 0.1V lower than the diode conduction voltage drop in the system conversion formula, the control unit 322 will convert the temperature obtained based on the collected voltage Vadc to 41°C, and the system will shut down the electric field therapy when it is not necessary, thereby affecting the electric field output and treatment duration.

[0098] In order to solve the above problem, in some implementations, the electrode sheet configuration parameters included in the encrypted information may include a diode type. The diode type will indicate the conduction voltage drop of the diode configured on the current electrode unit 312. Before the electrode sheet 310 leaves the factory, the information of the diode type configured in the electrode sheet 310 may be written into the initial parameters of the encrypted information.

[0099] In this case, the adapter 320 will determine the conduction voltage drop of the diode used in the electrode sheet 310 based on the diode type in the encrypted information obtained, and determine the temperature of the electrode unit 312 in the electrode sheet 310 based on the conduction voltage drop of the diode, thereby generating control information for the electrode sheet 310 in response to the encrypted information obtained from the encryption unit 311. For example, the control unit 322 in the adapter 320 can determine the conversion formula for obtaining the temperature of the thermistor based on the conduction voltage drop of the diode indicated in the encrypted information, and determine the temperature of the electrode unit 322 based on the calculated temperature of the thermistor Rt, and then determine whether the current electrode unit 312 is within the normal operating temperature range. The above temperature information can be used as control information for determining whether the electrode sheet 310 is working normally. In response to the measured temperature exceeding the preset temperature range, the tumor electric field treatment system 300 can be controlled to stop working.

[0100] The electrode sheet status parameter included in the encrypted information can be used to indicate the usage status of the electrode sheet 310, such as whether the electrode sheet 310 has been used, the length of time it has been used, etc. Since the performance of the electrode sheet 310 will deteriorate after being used for a period of time, by obtaining the electrode sheet status parameter indicating the usage status of the electrode sheet 310, the adapter 320 can generate appropriate control information according to the usage status of the electrode sheet 310.

[0101] In some implementations, the electrode pad status parameter may include at least one of an electrode pad production date, an electrode pad usage status, and an electrode pad activation date.

[0102] In some examples, the electrode sheet state parameter may include the electrode sheet production date. During the production process of the electrode sheet 310 or after the production is completed, the initial parameters of the electrode sheet 310 including the electrode sheet production date may be written in the encryption unit 311. The adapter 320 may obtain the electrode sheet production date of the electrode sheet 310 from the encrypted information obtained. Further, the adapter 320 may also obtain the time of the real-time clock RTC, wherein the time of the RTC may indicate the current date. The production duration of the electrode sheet 310 may be determined according to the time of the RTC and the electrode sheet production date indicated in the encrypted information. That is, the production duration of the electrode sheet 310 may be determined based on the time difference obtained by subtracting the electrode sheet production date from the RTC time. Whether the electrode sheet 310 has exceeded the shelf life may be determined by comparing the production duration of the electrode sheet 310 with the production period preset in the adapter 320 or the electric field generator 330. A fault signal for the electrode sheet 310 is generated in response to the production duration of the electrode sheet 310 exceeding the preset production period (i.e., exceeding the shelf life). The fault signal may indicate that tumor treatment field system 300 should be disabled.

[0103] By using the electrode sheet production date contained in the encrypted information, the tumor electric field therapy system 300 can identify the production time of the electrode sheet 310 currently in use, thereby being able to identify the electrode sheet 310 that has exceeded its shelf life and prevent the tumor electric field therapy system 300 from using the electrode sheet 310 that has exceeded its shelf life for treatment.

[0104] In some examples, the electrode sheet state parameter may include the electrode sheet activation date. In the initial parameters of the encrypted information of the electrode sheet 310, the electrode sheet activation date may be set to a default initial value. When the electrode sheet 310 is activated for the first time, the electrode activation date in the encrypted information may be updated to the current date (e.g., the time of the RTC) by the control unit 322 of the adapter 320, indicating that the electrode sheet 310 has started to be used. While the electrode sheet 310 is in use, the control unit 322 may start timing. If the use time of the electrode sheet 310 exceeds the predetermined use period (e.g., the threshold value of the use time set in advance) in the adapter 320 or the electric field generator 330, a fault signal for the electrode sheet 310 may be generated, thereby realizing the generation of control information for the electrode sheet 310 in response to the encrypted information obtained from the encryption unit 311. The fault signal may indicate that the tumor electric field treatment system 300 is disabled and reminds to replace the new electrode sheet 310. In some cases, the adapter 320 may identify that the electrode sheet activation date in the encrypted information obtained is not the default initial value. This means that the electrode sheet 310 has been previously activated. In this case, the adapter 320 can obtain the time of the RTC and determine the usage time of the electrode sheet 310 based on the time of the RTC and the activation date of the electrode sheet obtained in the encryption information. That is, the usage time of the electrode sheet 310 can be determined based on the time difference between the time of the RTC and the activation date of the electrode sheet. In response to the usage time of the electrode sheet 310 exceeding the predetermined usage period, a fault signal for the electrode sheet 310 can be generated, thereby realizing the generation of control information for the electrode sheet 310 in response to the encrypted information obtained from the encryption unit 311.

[0105] In some examples, the electrode sheet status parameter may include the electrode sheet usage status. The electrode sheet usage status may be used to indicate whether the current electrode sheet 310 is valid. The adapter 320 may generate a fault signal for the electrode sheet 310 in response to the electrode sheet usage status in the acquired encrypted information indicating that the electrode sheet 310 has been used. In the initial parameters of the electrode sheet 310, the electrode sheet usage status may be set to a default initial value. When the electrode sheet 310 has been used, especially when the electrode sheet 310 has been used for more than a predetermined service life, the information on the electrode sheet usage status stored in the encryption unit 311 may be modified to indicate that the electrode sheet 310 has been used. For example, the initial value of the electrode sheet usage status may be set to "new". When the usage time of the electrode sheet 310 reaches the predetermined service life, the electrode sheet usage status of the electrode sheet 310 may be updated to "old". When the adapter 320 reads from the encrypted information that the electrode sheet usage status of the electrode sheet 310 is old, it can be considered that the current electrode sheet 310 is an invalid electrode sheet, and control information is generated to disable the tumor electric field treatment system 300.

[0106] Figure 5 A schematic block diagram of the circuit connection of an electrode sheet and an adapter in a tumor electric field treatment system according to an embodiment of the present disclosure is shown.

[0107] like Figure 5 As shown, the tumor electric field treatment system 500 may include an electrode sheet 510 and an adapter 520 .

[0108] The electrode sheet 510 includes a flexible circuit board 513 and 20 electrode units 511 arranged thereon. A corresponding thermistor 5111 and a diode 5112 are arranged in each electrode unit 511, and the thermistor 5111 and the diode 5112 together constitute the aforementioned temperature detection unit. An encryption unit 512 is also arranged on the flexible circuit board 513.

[0109] The electrode unit 511 may be used to generate an alternating current signal under the control of an alternating current signal received from an electric field generator (not shown) to achieve electric field therapy.

[0110] The encryption unit 512 can be used to store encryption information corresponding to the electrode unit 511. For example, the encryption information can include the source identification, electrode unit type, diode type, electrode sheet production date, electrode sheet usage status and electrode sheet activation date of the electrode unit 511. Different encryption information parameters can be stored in different addresses of the encryption unit 512. For example, the encryption unit address can be assigned as follows: encryption unit address 1 is the company code ('XXXX'); encryption unit address 2 is the production date ('20220203'); encryption unit address 3 is the electrode activation status ('new' indicates a new electrode sheet, 'old' indicates an invalid electrode sheet); encryption unit address 4 is the electrode sheet activation date ('20210203' indicates that the electrode has not been turned on and can be used for a preset duration); encryption unit address 5 is the electrode unit type ('9' indicates 9 ceramic sheet electrodes, '13' indicates 13 ceramic sheet electrodes, and '20' indicates 20 ceramic sheet electrodes); encryption unit address 6 is the diode type ('20' indicates a conduction voltage drop of 0.2V, '30' indicates a conduction voltage drop of 0.3V, '40' indicates a conduction voltage drop of 0.4V, and '50' indicates a conduction voltage drop of 0.5V). Figure 5 As shown, each electrode unit 511 is provided with a corresponding diode 5112. Due to different batches of electrode sheets 510, the types of diodes 5112 may be different. Different types of diodes 5112 may result in different voltage drops on diodes 5112. Therefore, the voltage division of the thermistor 5111 under the same power supply VCC is different, so the collected temperature of the electrode unit 511 may be different from the actual temperature. The content in brackets after the above encrypted information is an exemplary initial parameter.

[0111] The adapter 520 includes a control unit 521 , an analog-to-digital conversion unit 522 , a plurality of pull-up resistors 523 , a plurality of switches 524 , a serial communication unit 525 , and a decryption unit 526 .

[0112] Among them, the control unit 521 is used to coordinate and control each other unit. The analog-to-digital conversion unit 522 is used to realize the analog-to-digital conversion between the control unit 521 and the signal collected at the electrode unit 511. The pull-up resistor 523 is used to control the level of the electrode unit 511. The switch 524 is used to control the circuit closure of the electrode unit 511 and the encryption unit 512 of the electrode sheet 510 during the temperature measurement period. The serial communication unit 525 can be used to communicate with an external device (such as an electric field generator). The decryption unit 526 can be used to encrypt the information to be written into the encryption unit 512 or to decrypt the information read from the encryption unit 512.

[0113] The following will describe Figure 5 The working principle of the tumor electric field treatment system is shown in FIG.

[0114] Plug the adapter 520 into the new electrode sheet 510. When powered on, the adapter 520 controls the switch 524 to close the switch 524-1. The ground wire of the encryption unit 512 in the electrode sheet 510 is connected to the ground wire of the adapter 520. The control unit 521 of the adapter 520 can read the data of the encryption unit address 1 to 5 through the decryption unit 526, and obtain the corresponding data through the key decryption.

[0115] If the decryption unit 526 communicates with the encryption unit 512 for multiple times but all fail, the decryption unit 526 will feedback the data acquisition failure to the control unit 521. The control unit 521 will therefore consider the connected electrode sheet 510 to be an invalid electrode and issue an alarm.

[0116] When the information stored in the encryption unit 512 is obtained, the control unit 521 reads the data of the decryption unit 526 and parses the obtained information. The specific process is as follows:

[0117] The control unit 521 obtains the company code stored in the encryption unit address 1 and compares it with the preset code in the adapter 520 or the host (not shown), and the host (not shown) is the aforementioned electric field generator. If the code is the same, the electrode sheet 510 can be used. If the code is not the same, the control unit 521 considers that the connected electrode sheet 510 is an invalid electrode sheet and feeds back fault information to the host (not shown), so that the host (not shown) cannot start treatment and alarms.

[0118] The control unit 521 obtains the production date of the encrypted unit address 2 and compares it with the date of the RTC clock in the control unit 521. If the time difference (RTC clock date minus the production date of the electrode sheet 510) is less than the shelf life, the electrode sheet 510 can be used. If the time difference exceeds the shelf life, the control unit 521 considers that the connected electrode sheet 510 is an invalid electrode sheet 510 and can no longer be used. The control unit 521 will feedback the fault information to the host (not shown), so that the host (not shown) cannot start treatment and an alarm prompts.

[0119] If the control unit 521 obtains that the electrode sheet usage status of the encryption unit address 3 is 'new', the control unit 521 determines that the electrode sheet 510 is a new electrode sheet and can be used. If the electrode sheet usage status is 'old', the control unit 521 determines that it is an invalid electrode sheet 510 and cannot be used. The control unit 521 will feedback the fault information to the host (not shown), so that the host (not shown) cannot start treatment and an alarm prompts.

[0120] The control unit 521 obtains the activation date of the electrode sheet at encryption unit address 4 as the factory parameter of the activation time '20xxxxxx', indicating that the electrode sheet 510 has not been activated and can still be used for a preset duration. When the host (not shown) turns on the electric field therapy, the control unit 521 will obtain the time and date of the RTC (for example, '20230304' means March 4, 2023), and write the time and date into the encryption unit address 4 through the decryption unit 526, indicating that the electrode sheet 510 has started to be used. At the same time, the control unit 521 starts timing, indicating the usage time of the electrode sheet 510. If the usage time of the electrode sheet 510 reaches the preset time, the control unit 521 feedbacks the fault information to the host (not shown). The host (not shown) will stop generating an electric field and alarm, and the control unit 521 writes the parameter 'old' into the encryption unit address 3 through the decryption unit 526. If the activation date of the electrode sheet at encryption unit address 4 is not '20xxxxxx', it means that the electrode sheet 510 has been activated. At the same time, the control unit 521 obtains the RTC time and date, and calculates the difference with the activation date of the electrode sheet. The time difference indicates how long the electrode sheet has been used. If the time difference is less than the preset time, the control unit 521 will not alarm, and the electrode sheet can be used normally. If the time difference is greater than the preset time, it means that the electrode sheet 510 has been used for too long and cannot be used. The control unit 521 can feedback fault information to the host (not shown), so that the host (not shown) cannot start treatment and alarms. At the same time, the control unit 521 writes the parameter 'old' into the encryption unit address 3 through the decryption unit 526.

[0121] The control unit 521 obtains the electrode unit type of the encrypted unit address 5 as '20', indicating that the electrode sheet 510 has 20 electrode units 511, and each of the 20 electrode units 511 is provided with a temperature sensor (i.e., thermistor 5111) to monitor the temperature of the electrode unit 511. Specifically, the adapter 520 can determine that the electrode unit type is "20" based on the obtained encrypted information, which means that there are 20 electrode units 511 in the electrode sheet 510, and therefore 20 temperature sensors are distributed to monitor the temperature of the electrode unit 511. When it is detected that there is a temperature that does not meet the preset temperature range (i.e., the normal operating temperature range) among the 20 collected temperature values, it can be determined that there is an abnormality in the electrode sheet 510, and a fault signal can be generated to prohibit the tumor electric field treatment system 500 from continuing to work.

[0122] The control unit 521 obtains the voltage drop Vd of the diode 5112 at the encryption unit address 6, so that the control unit 521 can identify the diode 5112 model of the electrode sheet 510. When Vd is '20', it means the on-state voltage drop is 0.2V. The control unit 521 detects the voltage at Vadc, and then substitutes Vd=0.2 and the detected Vadc into formula (6) to convert the resistance value of the thermistor 5111, and then converts the temperature value of the thermistor 5111 by formula (1). At this time, the collected temperature is consistent with the actual temperature of the thermistor 5111. When Vd is '30', it means the on-state voltage drop is 0.3V, the control unit 521 uses formula (4) to convert the resistance value of the thermistor 5111, and then converts the temperature value of the thermistor 5111 by formula (1). At this time, the collected temperature is consistent with the actual temperature of the thermistor 5111. When Vd is '40', indicating a conduction voltage drop of 0.4V, the control unit 521 uses formula (3) to convert the resistance value of the thermistor 5111, and then converts the temperature value of the thermistor 5111 using formula (1). At this time, the collected temperature is consistent with the actual temperature of the thermistor 5111. When Vd is '50', indicating a conduction voltage drop of 0.5V, the control unit 521 uses formula (5) to convert the resistance value of the thermistor 5111, and then converts the temperature value of the thermistor 5111 using formula (1). At this time, the collected temperature is consistent with the actual temperature of the thermistor 5111.

[0123] Each time the host (not shown) is powered on again, the control unit 521 of the adapter 520 executes the above process so that different types of diodes 5115 in the electrode sheet 510 can be automatically identified by the encryption unit 512 and the corresponding conversion formula for the on-state voltage drop can be used to avoid a large error between the temperature of the thermistor 5111 collected by the control unit and the actual temperature, thereby affecting the effect of the electric field therapy.

[0124] Figure 6A schematic block diagram of circuit connections of another electrode sheet and an adapter of a tumor electric field treatment system according to an embodiment of the present disclosure is shown.

[0125] like Figure 6 As shown, the tumor electric field treatment system 600 may include an electrode sheet 610 and an adapter 620 .

[0126] The electrode sheet 610 includes a flexible circuit board 613 and 13 electrode units 611 arranged thereon. A corresponding thermistor 6111 and a diode 6112 are arranged in each electrode unit 611. An encryption unit 612 is also arranged on the flexible circuit board 613.

[0127] The adapter 620 is provided with a control unit 621 , an analog-to-digital conversion unit 622 , a pull-up resistor 623 , a switch 624 , a serial communication unit 625 and a decryption unit 626 .

[0128] In tumor electric field therapy system 600, due to the reduction in the number of electrode units 611, switch 624-4 in switch 624 is not connected to any electrode unit 611. However, adapter 620 used in tumor electric field therapy system 600 can have the same configuration as adapter 520 used in tumor electric field therapy system 500, which allows the same adapter to support the connection of electrode sheets of different configurations.

[0129] Since the adapter 620 is the same as the adapter 520, Figure 5 The working principle of tumor treatment field system 500 described above can also be applied to tumor treatment field system 600, with the only difference being:

[0130] The control unit 621 obtains the electrode unit type of the encrypted unit address 5 as '13', indicating that the electrode sheet 610 has 13 electrode units 611, and each of the 13 electrode units 611 is provided with a temperature sensor to monitor the temperature of the electrode unit 611. Specifically, the adapter 620 can determine that the electrode unit type is "13" based on the obtained encrypted information, which means that there are 13 electrode units 611 in the electrode sheet 610, and therefore 13 temperature sensors (i.e., thermistors 6111) are distributed to monitor the temperature of the electrode unit 611. When it is detected that the number of temperatures that meet the preset temperature range (i.e., the normal operating temperature range) among the 20 collected temperature values ​​is different from 13, it can be determined that there is an abnormality in the electrode sheet 610, and a fault signal can be generated to prohibit the tumor electric field treatment system 600 from continuing to work.

[0131] Figure 7 A schematic block diagram of circuit connections of another electrode sheet and an adapter of a tumor electric field treatment system according to an embodiment of the present disclosure is shown.

[0132] like Figure 7 As shown, the tumor electric field treatment system 700 may include an electrode sheet 710 and an adapter 720 .

[0133] The electrode sheet 710 includes a flexible circuit board 713 and nine electrode units 711 arranged thereon. A corresponding thermistor 7111 and a diode 7112 are arranged in each electrode unit 711. An encryption unit 712 is also arranged on the flexible circuit board 713.

[0134] The adapter 720 includes a control unit 721 , an analog-to-digital conversion unit 722 , a pull-up resistor 723 , a switch 724 , a serial communication unit 725 , and a decryption unit 726 .

[0135] In tumor electric field therapy system 700, due to the reduction in the number of electrode units 711, switches 724-3 and 724-4 in switch 724 are not connected to any electrode unit 711. However, adapter 720 used in tumor electric field therapy system 700 can have the same configuration as adapter 520 used in tumor electric field therapy system 500, which allows the same adapter to support the connection of electrode sheets of different configurations.

[0136] Since the adapter 720 is the same as the adapter 520, Figure 5 The working principle of tumor treatment field system 500 described above can also be applied to tumor treatment field system 700, with the only difference being:

[0137] The control unit 721 obtains the electrode unit type of the encrypted unit address 5 as '9', indicating that the electrode sheet 710 has 9 electrode units 711, and each of the 9 electrode units 711 is provided with a temperature sensor to monitor the temperature of the electrode unit 711. Specifically, the adapter 720 can determine that the electrode unit type is "9" based on the obtained encrypted information, which means that there are 9 electrode units 711 in the electrode sheet 710, and therefore 9 temperature sensors (thermistors 7111) are distributed to monitor the temperature of the electrode unit 711. When it is detected that the number of temperatures that meet the preset temperature range (i.e., the normal operating temperature range) among the 20 collected temperature values ​​is different from 9, it can be determined that there is an abnormality in the electrode sheet 610, and a fault signal can be generated to prohibit the tumor electric field treatment system 600 from continuing to work.

[0138] Figure 8 Schematic diagram of the internal structure of an adapter according to an embodiment of the present disclosure.

[0139] like Figure 8As shown, the adapter 800 includes a first connector 801, a control unit 802, an ADC unit 803, a plurality of switch units 804 each consisting of a plurality of corresponding control switches (such as control switches K1, K2, K3 and K4), and a serial communication unit 805. The control unit 802 is used to configure the switch states of the plurality of control switches K1, K2, K3, K4 of the plurality of switch units 804. The ADC unit 803 is connected to the control unit 802. The ADC unit 803 is used to sample the analog temperature signal detected by the temperature sensor provided on the electrode unit, obtain a plurality of AD sampling values, and send the plurality of AD sampling values ​​to the control unit 802, so that the control unit 802 determines the temperature of the electrode unit according to the plurality of AD sampling values.

[0140] The plurality of first connectors 801 are connected to the second connector 806 through the alternating power lines X1, Y1, X2 and Y2 respectively, and the first connectors 801 are also connected to a corresponding switch unit 804 respectively, and are all connected to the ADC unit 803. The second connector 806 is connected to the serial communication unit 805 through a receiving data line and a sending data line, the VCC pin of the second connector 806 is connected to the power supply end of the control unit 802, and the GND pin of the second connector 806 is grounded.

[0141] Each first connector 801 is also connected to a corresponding decryption unit 807. The decryption unit 807 is connected to an encryption unit provided in a corresponding electrode sheet through the first connector 801, and obtains encryption information related to the electrode sheet from the encryption unit.

[0142] use Figure 8 The adapter 800 shown in FIG. 1 can simultaneously connect multiple different electrode sheets and obtain encrypted information related to different electrode sheets, thereby realizing control over multiple different electrode sheets. Figure 8 The adapter 800 shown in FIG. Figure 1 , 3 , the adapter described in 5-7.

[0143] Fig. 9 A schematic diagram of a tumor electric field treatment system 900 according to the present invention is shown.

[0144] Fig. 9 4 electrode sheets 901 are shown. Every two electrode sheets 901 are arranged as a pair on the patient's body surface. The adapter 902 is electrically connected to each electrode sheet 901. The electric field generator 903 is electrically connected to the adapter 902. The electric field generator 903 generates an alternating electric signal for the tumor electric field, and transmits the alternating electric signal to each electrode sheet 901 through the adapter 902, so as to apply an alternating electric field to the patient's tumor site for tumor treatment. Fig. 9Each electrode sheet 901 shown in FIG. 1 includes 20 electrode units and their arrangement. However, the solution disclosed in the present invention is not limited thereto. Those skilled in the art can arrange the number and arrangement of the electrode units according to actual conditions.

[0145] A first connector 904 is connected between each electrode sheet 901 and the adapter 902, and the first connector 904 is suitable for connecting the corresponding electrode sheet 901 to the adapter 902. The first connector 904 includes a first plug 41 and a first socket 42 provided on the adapter 902. The electrode sheet 901 is electrically connected to the first plug 41 through a first cable 905. The first plug 41 and the first socket 42 can be press-type spring connectors, that is, the first connector 904 connects the adapter 902 to the electrode sheet 901 in the form of a connector.

[0146] A second connector 906 is provided between the adapter 902 and the electric field generator 903, and the second connector 906 is suitable for connecting the electric field generator 903 to the adapter 902. The adapter 902 and the electric field generator 903 are connected through the second plug 61 and the second socket 62, and the adapter 902 is electrically connected to the second plug 61 through the second cable 907. The second plug 61 and the second socket 62 are press-type spring connectors, that is, the second connector 906 connects the adapter 902 and the electric field generator 903 in the form of a connector.

[0147] Fig.10 An exemplary flow chart of a method performed by a tumor treating field system according to an embodiment of the present disclosure is shown.

[0148] In step S1002, encryption information stored in the encryption unit may be obtained.

[0149] In step S1004, control information for the electrode sheet may be generated in response to the encryption information acquired from the encryption unit.

[0150] Can be combined with Figures 1 to 9 The tumor treating fields system described herein is used to perform Fig.10 The method 1000 shown in FIG. Figures 1 to 9 The various advantages of the embodiments of the present disclosure described above are also applicable to method 1000 and will not be described in detail herein.

[0151] Although the present disclosure has been illustrated and described in detail in the drawings and the foregoing description, such illustration and description should be considered illustrative and schematic, not restrictive; the present disclosure is not limited to the disclosed embodiments. By studying the drawings, the disclosure and the appended claims, those skilled in the art will be able to understand and implement variations to the disclosed embodiments when practicing the claimed subject matter. In the claims, the word "comprising" does not exclude other elements or steps that are not listed, the indefinite article "a" or "an" does not exclude a plurality, the term "plurality" means two or more, and "based on" should be interpreted as "based at least in part on". The mere fact that certain measures are recorded in mutually different dependent claims does not indicate that a combination of these measures cannot be used to advantage.

Claims

1. A tumor electric field treatment system, include: An electrode sheet, the electrode sheet comprising a plurality of electrode units and an encryption unit, the encryption unit and the plurality of electrode units being connected to a same ground line, wherein the encryption unit stores encryption information corresponding to the plurality of electrode units; and an adapter connected between the electrode sheet and the electric field generator, the adapter being configured to transmit the alternating current signal generated by the electric field generator to the electrode unit of the electrode sheet, The adapter is coupled to the encryption unit and is configured to generate control information for the electrode sheet in response to the encryption information obtained from the encryption unit.

2. The tumor electric field treatment system according to claim 1, in, The adapter is coupled to the encryption unit via at least one communication line, and obtains the encryption information via the at least one communication line.

3. The tumor electric field treatment system according to claim 2, in, The adapter is also configured to: Closing at least one switch connected to the ground wire so that the adapter is electrically connected to the electrode unit and the encryption unit in the electrode sheet; and Communicate with the encryption unit to obtain encryption information stored in the encryption unit.

4. The tumor electric field treatment system according to any one of claims 1 to 3, in, The encrypted information includes at least one of the following items related to the electrode sheet: Source identification, electrode status parameters, electrode configuration parameters.

5. The tumor electric field treatment system according to claim 4, in, The electrode sheet configuration parameters include at least one of an electrode unit type and a diode type.

6. The tumor electric field treatment system according to claim 5, in, The encrypted information obtained includes the electrode unit type, Wherein, generating control information for the electrode sheet in response to the encrypted information obtained from the encryption unit includes: Determining the number of electrode units corresponding to the electrode unit type; Acquiring a predetermined number of electrode unit temperatures collected by a temperature detection unit; A fault signal for the electrode sheet is generated in response to determining that a number of the predetermined number of electrode unit temperatures that conform to a preset temperature range is different from the number of electrode units.

7. The tumor electric field treatment system according to claim 5, in, The encrypted information obtained includes the diode type, Wherein, generating control information for the electrode sheet in response to the encrypted information obtained from the encryption unit includes: Determining the conduction voltage drop of the diode used by the electrode sheet based on the diode type; and The temperature of the electrode unit in the electrode sheet is determined based on the conduction voltage drop.

8. The tumor electric field treatment system according to claim 4, in, The electrode sheet status parameter includes at least one of the electrode sheet production date, the electrode sheet usage status and the electrode sheet activation date.

9. The tumor electric field treatment system according to claim 8, in, The encrypted information obtained includes the production date of the electrode sheet, Wherein, generating control information for the electrode sheet in response to the encrypted information obtained from the encryption unit includes: Obtaining the time of the real-time clock RTC of the adapter; Determine the production time of the electrode sheet according to the RTC time and the production date of the electrode sheet; A fault signal for the electrode sheet is generated in response to the electrode sheet having been produced for a period exceeding a predetermined production deadline.

10. The tumor electric field treatment system according to claim 8, in, The encrypted information obtained includes the electrode activation date of the electrode, Wherein, generating control information for the electrode sheet in response to the encrypted information obtained from the encryption unit includes: Obtaining the time of the real-time clock RTC of the adapter; Determine the usage time of the electrode sheet according to the RTC time and the activation date of the electrode sheet; The fault signal for the electrode pad is generated in response to the electrode pad being used for a period of time exceeding a predetermined usage period.

11. The tumor electric field treatment system according to claim 8, in, The encrypted information obtained includes the usage status of the electrode sheet, Wherein, generating control information for the electrode sheet in response to the encrypted information obtained from the encryption unit includes: The fault signal for the electrode pad is generated in response to the electrode pad usage status indicating that the electrode pad has been used.

12. The tumor electric field treatment system of claim 4, wherein the encrypted information includes the source identifier, in, Generating control information for the electrode sheet in response to the encrypted information obtained from the encryption unit includes: The fault signal is generated in response to the source identification being different than a predetermined source identification.

13. The tumor electric field treatment system according to any one of claims 1 to 3, in, Generating control information for the electrode sheet in response to the encrypted information obtained from the encryption unit includes: A fault signal is generated in response to the encrypted information being invalid information.

14. The tumor electric field treatment system according to any one of claims 1 to 3, in, The adapter is also configured to: The initial parameters of the encryption information are encrypted using a key, and the encrypted initial parameters of the encryption information are written into the encryption unit.

15. The tumor electric field treatment system according to claim 14, in, The adapter is also configured to: The update parameters of the encryption information are encrypted using a key, and the encrypted update parameters of the encryption information are written into the encryption unit to replace the initial parameters.

16. A method performed by a tumor treatment field system, wherein the tumor treatment field system is the tumor treatment field system according to any one of claims 1 to 15, wherein the method include: Obtaining the encryption information stored in the encryption unit; Control information for the electrode sheet is generated in response to the encrypted information acquired from the encryption unit.

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