A stand-alone column oven for liquid chromatography

Abstract

The present invention discloses a stand-alone column temperature box for liquid chromatography, which relates to the technical field of column temperature boxes and includes a column temperature box body, wherein a plurality of partition frames are fixedly connected to the inner side of the column temperature box body, a support block is fixedly connected to the inner side of the partition frame, a liquid chromatography column is arranged on the outer side of the support block, the left and right ends of the liquid chromatography column are fixedly connected with connectors, the inner side of the partition frame is provided with an installation unit for installing the liquid chromatography column, and the left side of the column temperature box body is fixedly connected with a fixed cover and a pump body. The stand-alone column temperature box for liquid chromatography, by being provided with a plurality of partition frames, can accommodate a plurality of chromatography columns, so that the same instrument can conveniently switch and detect multiple projects, and through the guide plate, guide block, fixed rod, installation box, rotating tube, installation head, gear part 2, tooth plate and electric push rod, it is convenient to control the installation heads on the left and right sides to rotate and approach each other, so that the liquid chromatography column can be quickly connected to the pump body, reducing the workload of the staff and simplifying the operation.

Description

Technical Field

[0001] The invention relates to the technical field of column ovens, in particular to an independent column oven for liquid chromatography. Background Art

[0002] The column oven is a key component in analytical instruments such as high performance liquid chromatography (HPLC) and gas chromatography (GC). It is used to precisely control the temperature of the chromatographic column to ensure a stable and reproducible separation process.

[0003] After searching, the Chinese patent with application number "CN202320409462.3" is specifically a column oven for liquid chromatography. The experimenter installs the analytical column to be used according to needs, connects it to the box body through the first tube sleeve and the second tube sleeve, and places the first tube sleeve on the clamp in turn to achieve preliminary fixation of the analytical column and facilitate the subsequent disassembly and installation of the analytical column.

[0004] When installing a liquid chromatograph, the liquid chromatograph column needs to be connected to the pump body. The pump is the "heart" of the liquid chromatograph system and is responsible for providing a stable mobile phase flow rate and pressure to push the sample through the chromatographic column for separation. The liquid chromatograph column is connected to the pump body through the first sleeve and the second sleeve. When connecting, the staff needs to use the handle to rotate the joints on both sides so that the connector and the liquid chromatograph column are installed in a spiral manner. Manual rotation of the connector can easily make the connection too loose, resulting in a loose connection between the pump body and the liquid chromatograph column, and liquid leakage, which is not conducive to sample separation. Summary of the Invention

[0005] In view of the shortcomings of the prior art, the present invention provides a stand-alone liquid chromatography column oven, which solves the problem that the liquid chromatography column is easily loosened when it is installed manually.

[0006] To achieve the above objectives, the present invention is implemented through the following technical solutions:

[0007] A stand-alone column oven for liquid chromatography comprises a column oven body, a plurality of partition frames are fixedly connected to the inner side of the column oven body, a support block is fixedly connected to the inner side of the partition frame, a liquid chromatography column is arranged on the outer side of the support block, the left and right ends of the liquid chromatography column are fixedly connected to connectors, an installation unit for installing the liquid chromatography column is arranged on the inner side of the partition frame, a fixed cover and a pump body are fixedly connected to the left side of the column oven body, a controller is fixedly connected to the front side of the fixed cover, a box door is arranged on the front side of the column oven body, and the installation unit comprises a connecting assembly and a sealing assembly.

[0008] The outer ends of the two guide wheels are fixedly connected to the side plates at the top and bottom, the outer ends of the two guide wheels are fixedly connected to the side plates at the top and bottom, the upper ends of the two guide wheels are fixedly connected to the side plates at the

[0009] Preferably, the outer sides of the guide blocks on the left and right sides are fixedly connected with rotating block 1, the outer sides of the rotating block 1 on the left and right sides are rotatably connected with inclined plates, the outer sides of the inclined plates are rotatably connected with rotating block 2, the front side of the rotating block 2 is fixedly connected with a push plate, and an electric push rod is fixedly connected between the rear side of the push plate and the inner wall of the partition frame.

[0010] Preferably, the inner side of the connecting head is provided with an internal thread, and the outer side of the mounting head is provided with an external thread adapted to the internal thread.

[0011] Preferably, the outer side of the mounting head is fixedly connected with a sealing cover, the sealing assembly includes a sealing airbag, the sealing airbag is fixedly connected to the inner side of the sealing cover, a plurality of connecting channels are provided on the inner side of the rotating tube, a branch pipe is fixedly connected between the connecting channel and the sealing airbag, the inner side of the mounting box is fixedly connected with a fixed cavity, the inner side of the fixed cavity and the inner wall of the mounting box are both provided with through holes, the inner side of the partition frame is fixedly connected with an air box, a piston plate is provided on the inner side of the air box, the outer side of the piston plate is fixedly connected with a moving rod, the outer end of the moving rod passes through the right side of the air box and is fixedly connected with a connecting block, the connecting block is fixedly connected to the guide block, a delivery pipe is fixedly connected between the air box and the fixed cavity, and the piston plate and the moving rod are both slidably connected to the air box.

[0012] Preferably, the left side of the installation box on the left is fixedly connected with a liquid inlet pipe, the outer ends of multiple liquid inlet pipes are fixedly connected with connecting pipes, a fixed pipe is fixedly connected between the connecting pipe and the pump body, and the right side of the installation box on the right is fixedly connected with a liquid outlet pipe, solenoid valve 2 is provided on the outside of the liquid outlet pipe, and solenoid valve 1 is provided on the outside of the liquid inlet pipe.

[0013] Preferably, the outer ends of the liquid inlet pipe and the liquid outlet pipe pass through the outside of the column temperature box.

[0014] Beneficial effects:

[0015] The present invention provides a stand-alone column oven for liquid chromatography. Compared with the prior art, it has the following advantages:

[0016] Beneficial effects:

[0017] (1) The independent liquid chromatography column oven is provided with multiple partition frames to accommodate multiple chromatographic columns, which is convenient for the same instrument to switch between multiple projects for detection. The guide plate, guide block, fixed rod, mounting box, rotating tube, mounting head, gear part 2, gear plate and electric push rod are used to conveniently control the left and right mounting heads to rotate and approach each other, so that the liquid chromatography column can be quickly connected to the pump body, reducing the workload of the staff and simplifying the operation.

[0018] (2) The independent liquid chromatography column oven is provided with a sealing cover, a sealing airbag, an air box, a piston plate, a moving rod, a connecting block and a delivery pipe. When the liquid chromatography column is installed, the sealing airbag is expanded and cooperated with the sealing cover to increase the sealing performance of the liquid chromatography column installation and prevent liquid leakage. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is the overall three-dimensional structural diagram of the present invention;

[0020] Figure 2 It is a partial three-dimensional structural diagram of the present invention;

[0021] Figure 3 It is a three-dimensional structural diagram of the partition frame in the present invention;

[0022] Figure 4 It is a three-dimensional structural diagram of the installation unit in the present invention;

[0023] Figure 5 It is a partial three-dimensional structural diagram of the installation unit in the present invention;

[0024] Figure 6 for Figure 5 Enlarged view of point A in the middle;

[0025] Figure 7 It is a partially cutaway perspective structural diagram of the installation unit in the present invention;

[0026] Figure 8 A partially cutaway perspective structural diagram of a sealing assembly in the present invention;

[0027] Figure 9 It is a three-dimensional structural diagram of the liquid chromatography column in the present invention.

[0028] In the figure: 1. Column temperature chamber; 2. Partition frame; 3. Chamber door; 4. Support block; 5. Liquid chromatography column; 6. Mounting unit; 7. Fixed cover; 8. Controller; 9. Liquid inlet pipe; 10. Solenoid valve 1; 11. Connecting pipe; 12. Pump body; 13. Fixed pipe; 14. Liquid outlet pipe; 15. Solenoid valve 2; 16. Connector; 17. Internal thread; 61. Connecting assembly; 62. Sealing assembly

[0029] 611. Guide plate; 612. Guide block; 613. Rotating block 1; 614. Inclined plate; 615. Rotating block 2; 616. Push plate; 617. Electric push rod; 618. Fixed rod; 619. Mounting box; 6110. Gear plate; 6111. Mounting block; 6112. Rotating tube; 6113. Gear ring; 6114. Rotating shaft; 6115. Gear component 1; 6116. Bevel gear 1; 6117. Bevel gear 2; 6118. Control lever; 6119. Front block; 6120. Gear component 2; 6121. Mounting head; 6122. Sealing cover;

[0030] 621. Sealing airbag; 622. Branch pipe; 623. Connecting channel; 624. Through hole; 625. Fixed cavity; 626. Air box; 627. Piston plate; 628. Moving rod; 629. Connecting block; 6210. Delivery pipe. DETAILED DESCRIPTION

[0031] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0032] Example 1

[0033] See also Figure 1 - Figure 6 、 Figure 9The present invention provides a technical solution: a stand-alone column temperature box for liquid chromatography, comprising a column temperature box body 1, a plurality of partition frames 2 are fixedly connected to the inner side of the column temperature box body 1, a support block 4 is fixedly connected to the inner side of the partition frame 2, a liquid chromatography column 5 is arranged on the outer side of the support block 4, and the left and right ends of the liquid chromatography column 5 are fixedly connected to connectors 16, an installation unit 6 for installing the liquid chromatography column 5 is arranged on the inner side of the partition frame 2, a fixed cover 7 and a pump body 12 are fixedly connected to the left side of the column temperature box body 1, a controller 8 is fixedly connected to the front side of the fixed cover 7, a box door 3 is arranged on the front side of the column temperature box body 1, the installation unit 6 includes a connecting component 61 and a sealing component 62, a liquid inlet pipe 9 is fixedly connected to the left side of the left installation box 619, and the outer ends of the plurality of liquid inlet pipes 9 are fixedly connected There is a connecting pipe 11, and a fixed pipe 13 is fixedly connected between the connecting pipe 11 and the pump body 12. A liquid outlet pipe 14 is fixedly connected to the right side of the right installation box 619. A solenoid valve 2 15 is provided on the outside of the liquid outlet pipe 14, and a solenoid valve 10 is provided on the outside of the liquid inlet pipe 9. The outer ends of the liquid inlet pipe 9 and the liquid outlet pipe 14 pass through the outside of the column temperature box 1. When in use, multiple partition frames 2 are used to conveniently accommodate multiple liquid chromatography columns 5. Each liquid chromatography column 5 is spatially independent, which is convenient for the same instrument to easily switch and detect multiple projects, thereby improving the instrument's machine time utilization rate. The installation unit 6 is used to facilitate the rapid connection of the liquid chromatography column 5 to the pump body 12. The solenoid valve 10 and the solenoid valve 2 15 are provided to facilitate the control of the liquid chromatography column 5 and the pump body 12 for use in combination.

[0034] The connecting assembly 61 includes a guide plate 611, which is fixedly connected to the inner side of the partition frame 2 and is located on the left and right sides of the liquid chromatography column 5. The outer sides of the left and right guide plates 611 are slidably connected with guide blocks 612. The upper sides of the guide blocks 612 are fixedly connected with fixed rods 618. The upper ends of the fixed rods 618 are fixedly connected with mounting boxes 619. The side of the mounting box 619 close to the liquid chromatography column 5 is rotatably connected with a rotating tube 6112 and a rotating shaft 6114. The outer end of the rotating tube 6112 is fixedly connected with a mounting head 6121. The outer side of the rotating tube 6112 is fixedly connected with a gear ring 6113. The outer side of the rotating shaft 6114 is fixedly connected with a gear member 1 6115 meshing with the gear ring 6113. The outer end of the rotating shaft 6114 is fixedly connected with a bevel gear 1 6116. The outer side of the mounting box 619 is fixedly connected with a front block 6119. The front side of the front block 6119 is rotatably connected to a control rod 6118. The rear end of the control rod 6118 is fixedly connected to the bevel gear 2 6117 meshing with the bevel gear 1 6116, and the front end of the control rod 6118 is fixedly connected to the gear part 2 6120. The left and right inner walls of the partition frame 2 are fixedly connected to the mounting blocks 6111. The outer sides of the left and right mounting blocks 6111 are fixedly connected to the toothed plates 6110 meshing with the gear part 2 6120. The outer sides of the left and right guide blocks 612 are fixedly connected to the rotating block 1 613. The outer sides of the left and right rotating blocks 1 613 are rotatably connected to the inclined plates 614. The outer sides of the inclined plates 614 are rotatably connected to the rotating block 2 615. The front side of the rotating block 2 615 is fixedly connected to the push plate 616. The rear side of the push plate 616 is fixedly connected to the inner wall of the partition frame 2 with an electric push rod 617. The inner side of the connecting head 16 is provided with an internal thread 17, and the outer side of the mounting head 6121 is provided with an external thread adapted to the internal thread 17.

[0035] When installing the liquid chromatography column 5, the liquid chromatography column 5 is placed on the support block 4, and then the liquid chromatography column 5 is manually pressed to limit the position, and then the electric push rod 617 is controlled to drive the push plate 616 to move forward, and the push plate 616 drives the inclined plate 614 to rotate. Since the two inclined plates 614 are symmetrically distributed, the inclined plate 614 drives the guide block 612 to move, and the guide blocks 612 on both sides approach each other. The guide block 612 drives the fixed rod 618 to move, and the fixed rod 618 drives the installation box 619 to move. The installation box 619 drives the rotating tube 6112 to move, and the rotating tube 6112 drives the installation head 6121 to move, so that the installation head 6121 approaches the connector 16 on the liquid chromatography column 5. At the same time, the installation box 619 drives the control rod 6118 on the front block 6119 to move, and the control rod 6118 drives the gear Part 2 6120 moves, and since gear part 2 6120 is meshed with the tooth plate 6110, gear part 2 6120 drives the control rod 6118 to rotate, the control rod 6118 drives bevel gear 2 6117 to rotate, bevel gear 2 6117 drives bevel gear 1 6116 to rotate, bevel gear 1 6116 drives the rotating shaft 6114 to rotate, the rotating shaft 6114 drives gear part 1 6115 to rotate, gear part 1 6115 drives the gear ring 6113 to rotate, the gear ring 6113 drives the rotating tube 6112 to rotate, and the rotating tube 6112 drives the mounting head 6121 to rotate, so that the mounting head 6121 rotates while approaching the liquid chromatography column 5, so that the mounting head 6121 is spirally connected to the connector 16 on the liquid chromatography column 5, so that the liquid chromatography column 5 and the pump body 12 can be connected together conveniently and quickly.

[0036] Example 2

[0037] Based on the first embodiment, Figure 7 、 Figure 8 As shown, a stand-alone liquid chromatography column oven comprises a column oven body 1, a plurality of partition frames 2 are fixedly connected to the inner side of the column oven body 1, a support block 4 is fixedly connected to the inner side of the partition frame 2, a liquid chromatography column 5 is arranged on the outer side of the support block 4, the left and right ends of the liquid chromatography column 5 are fixedly connected to connectors 16, an installation unit 6 for installing the liquid chromatography column 5 is arranged on the inner side of the partition frame 2, a fixed cover 7 and a pump body 12 are fixedly connected to the left side of the column oven body 1, a controller 8 is fixedly connected to the front side of the fixed cover 7, and the column oven body 1 is fixedly connected to the left side of the column oven body 1. A box door 3 is provided on the front side, the installation unit 6 includes a connecting component 61 and a sealing component 62, the left side of the left installation box 619 is fixedly connected to the liquid inlet pipe 9, the outer ends of multiple liquid inlet pipes 9 are fixedly connected to connecting pipes 11, and a fixed pipe 13 is fixedly connected between the connecting pipe 11 and the pump body 12, the right side of the right installation box 619 is fixedly connected to the liquid outlet pipe 14, the outer side of the liquid outlet pipe 14 is provided with a solenoid valve 2 15, the outer side of the liquid inlet pipe 9 is provided with a solenoid valve 10, and the outer ends of the liquid inlet pipe 9 and the liquid outlet pipe 14 pass through the outside of the column temperature box 1.

[0038] The outer side of the mounting head 6121 is fixedly connected to a sealing cover 6122, and the sealing assembly 62 includes a sealing airbag 621, which is fixedly connected to the inner side of the sealing cover 6122. A plurality of connecting channels 623 are provided on the inner side of the rotating tube 6112, and a branch pipe 622 is fixedly connected between the connecting channel 623 and the sealing airbag 621. The inner side of the mounting box 619 is fixedly connected to a fixed cavity 625, and a through hole 624 is provided on the inner side of the fixed cavity 625 and the inner wall of the mounting box 619. The inner side of the partition frame 2 is fixedly connected to an air box 626, and a piston plate 627 is provided on the inner side of the air box 626. A moving rod 628 is fixedly connected to the outer side of the piston plate 627. The outer end of the moving rod 628 passes through the right side of the air box 626 and is fixedly connected to a connecting block 629. The connecting block 629 is fixedly connected to the guide block 612. The air box 626 and the fixed cavity 625 are fixedly connected. A delivery pipe 6210 is fixedly connected between them, and the piston plate 627 and the moving rod 628 are both slidably connected to the gas box 626. When the liquid chromatography column 5 is installed, the guide block 612 drives the connecting block 629 to move, the connecting block 629 drives the moving rod 628 to move, and the moving rod 628 drives the piston plate 627 to move. The piston plate 627 pushes the gas in the gas box 626 out and transports the gas in the gas box 626 to the fixed cavity 625 through the delivery pipe 6210, and transports the gas to the sealing airbag 621 through the through hole 624, the connecting channel 623 and the branch pipe 622. The sealing airbag 621 expands, making it easier for the sealing airbag 621 to seal the connector 16, making the connection of the liquid chromatography column 5 tighter and avoiding liquid leakage, and through the sealing cover 6122, the sealing cover 6122 is clamped on the connector 16 to increase the stability of the connection.

[0039] Working principle: When in use, the staff first places the liquid chromatography column 5 on the support block 4 and limits the liquid chromatography column 5 by hand, then controls the electric push rod 617 to push the push plate 616 to move, and under the action of the inclined plate 614, guide block 612, fixed rod 618, installation box 619, and rotating tube 6112, controls the installation heads 6121 on the left and right sides to move closer to each other, and at the same time, the installation box 619 drives the gear part 2 6120 to move, and under the action of the tooth plate 6110, control rod 6118, bevel gear 2 6117, bevel gear 1 6116, rotating shaft 6114, gear part 1 611 5 and the gear ring 6113, the mounting head 6121 is controlled to rotate, so that the mounting head 6121 is threadedly connected to the connector 16, which facilitates the rapid installation of the liquid chromatography column 5. At the same time, the guide block 612 drives the connecting block 629 to move. Under the action of the moving rod 628, the piston plate 627, the air box 626, the delivery pipe 6210, the fixed cavity 625, the connecting channel 623 and the branch pipe 622, the sealing airbag 621 is expanded, which facilitates the sealing operation of the sealing airbag 621 on the connector 16, thereby improving the sealing performance of the connection of the liquid chromatography column 5 and preventing liquid leakage.

[0040] It should be noted that, in this document, relational terms such as first and second, etc., are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprises," "comprising," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that includes a list of elements includes not only those elements but also other elements not explicitly listed, or elements inherent to such process, method, article, or apparatus.

[0041] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. A stand-alone column oven for liquid chromatography, comprising a column oven body (1), characterized in that: The inner side of the column temperature box (1) is fixedly connected to a plurality of partition frames (2), the inner side of the partition frame (2) is fixedly connected to a support block (4), the outer side of the support block (4) is provided with a liquid chromatography column (5), the left and right ends of the liquid chromatography column (5) are fixedly connected to connectors (16), the inner side of the partition frame (2) is provided with an installation unit (6) for installing the liquid chromatography column (5), the left side of the column temperature box (1) is fixedly connected to a fixed cover (7) and a pump body (12), the front side of the fixed cover (7) is fixedly connected to a controller (8), the front side of the column temperature box (1) is provided with a box door (3), and the installation unit (6) includes a connection component (61) and a sealing component (62); The connecting assembly (61) includes a guide plate (611), which is fixedly connected to the inner side of the partition frame (2) and is located on the left and right sides of the liquid chromatography column (5). The outer sides of the guide plates (611) on the left and right sides are slidably connected with guide blocks (612), the upper side of the guide block (612) is fixedly connected with a fixing rod (618), the upper end of the fixing rod (618) is fixedly connected with an installation box (619), and the installation box (619) is rotatably connected with a rotating tube (6112) and a rotating shaft (6114) on the side close to the liquid chromatography column (5), the outer end of the rotating tube (6112) is fixedly connected with a mounting head (6121), the outer side of the rotating tube (6112) is fixedly connected with a gear ring (6113), and the outer side of the rotating shaft (6114) is fixedly connected with a Gear piece 1 (6115) meshed with the gear ring (6113), the outer end of the rotating shaft (6114) is fixedly connected to bevel gear 1 (6116), the outer side of the mounting box (619) is fixedly connected to a front block (6119), the front side of the front block (6119) is rotatably connected to a control rod (6118), the rear end of the control rod (6118) is fixedly connected to bevel gear 2 (6117) meshed with bevel gear 1 (6116), the front end of the control rod (6118) is fixedly connected to gear piece 2 (6120), the left and right inner walls of the partition frame (2) are fixedly connected to mounting blocks (6111), and the outer sides of the mounting blocks (6111) on the left and right sides are fixedly connected to tooth plates (6110) meshed with gear piece 2 (6120); The outer side of the mounting head (6121) is fixedly connected to a sealing cover (6122), the sealing assembly (62) includes a sealing airbag (621), the sealing airbag (621) is fixedly connected to the inner side of the sealing cover (6122), the inner side of the rotating tube (6112) is provided with a plurality of connecting channels (623), a branch pipe (622) is fixedly connected between the connecting channels (623) and the sealing airbag (621), the inner side of the mounting box (619) is fixedly connected to a fixed cavity (625), the inner side of the fixed cavity (625) and the inner wall of the mounting box (619) are both provided with through holes (624). ), the inner side of the partition frame (2) is fixedly connected to an air box (626), the inner side of the air box (626) is provided with a piston plate (627), the outer side of the piston plate (627) is fixedly connected to a moving rod (628), the outer end of the moving rod (628) passes through the right side of the air box (626) and is fixedly connected to a connecting block (629), the connecting block (629) is fixedly connected to the guide block (612), a delivery pipe (6210) is fixedly connected between the air box (626) and the fixed cavity (625), and the piston plate (627) and the moving rod (628) are both slidably connected to the air box (626); The left side of the installation box (619) on the left side is fixedly connected to a liquid inlet pipe (9), the outer ends of the plurality of liquid inlet pipes (9) are fixedly connected to connecting pipes (11), a fixed pipe (13) is fixedly connected between the connecting pipe (11) and the pump body (12), the right side of the installation box (619) on the right side is fixedly connected to a liquid outlet pipe (14), the outer side of the liquid outlet pipe (14) is provided with a second solenoid valve (15), and the outer side of the liquid inlet pipe (9) is provided with a first solenoid valve (10).

2. The independent column oven for liquid chromatography according to claim 1, characterized in that: The outer sides of the guide blocks (612) on the left and right sides are fixedly connected to the first rotating block (613), the outer sides of the first rotating block (613) on the left and right sides are rotatably connected to the inclined plates (614), the outer sides of the inclined plates (614) are rotatably connected to the second rotating block (615), the front side of the second rotating block (615) is fixedly connected to the push plate (616), and the rear side of the push plate (616) and the inner wall of the partition frame (2) are fixedly connected to an electric push rod (617).

3. The independent column oven for liquid chromatography according to claim 1, characterized in that: The inner side of the connecting head (16) is provided with an internal thread (17), and the outer side of the mounting head (6121) is provided with an external thread adapted to the internal thread (17).

4. The independent column oven for liquid chromatography according to claim 1, characterized in that: The outer ends of the liquid inlet pipe (9) and the liquid outlet pipe (14) both pass through the outside of the column temperature box (1).

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