Implantable sensor packaging structure and biological characteristic signal acquisition system

Abstract

The invention discloses an implantable sensor packaging structure and a biological characteristic signal acquisition system, and relates to the technical field of medical instruments, and the implantable sensor packaging structure comprises a base; the guide pipe assembly is fixed on the surface of one side of the base; a plurality of sensor units are arranged in the catheter assembly, and each sensor unit is used for detecting different types of biological characteristic signals; wherein the side wall of the conduit assembly is provided with a detection window, and the detection window is used for exposing the sensor unit. The catheter assembly is integrated with a plurality of sensor units used for detecting different types of biological characteristic signals, the side wall of the catheter assembly is provided with the detection windows used for exposing the sensor units, and each sensor unit can collect the biological characteristic signals based on the corresponding detection window. The implantable sensor packaging structure is an integrated sensor with a single catheter and multiple detection windows, and the same implantable sensor packaging structure can collect various biological characteristic signals at the same time.

Description

Technical Field

[0001] This application relates to the technical field of medical devices, and particularly to an implantable sensor packaging structure and a biometric signal acquisition system. Background Art

[0002] An implantable sensor is a miniaturized sensing device that can be implanted into a living organism to collect biometric signals in real time and transmit the collected biometric signals to an external monitor in a wired or wireless manner. Its core value lies in long-term, in-situ, and dynamic tracking of target indicators, providing accurate data support for medical diagnosis.

[0003] Currently, conventional implantable sensor packaging structures are mostly single-mode designs, that is, the implantable sensor packaging structure only encapsulates a sensor chip for collecting a single biometric signal and can only be used for the collection of a single biometric signal. Summary of the Invention

[0004] In view of the above problems, this application provides an implantable sensor packaging structure and a biometric signal acquisition system to achieve the purpose that the implantable sensor packaging structure can collect multiple different biometric signals. The specific solutions are as follows:

[0005] In the first aspect of this application, an implantable sensor packaging structure is provided, including:

[0006] A base;

[0007] A catheter assembly fixed on one side surface of the base;

[0008] Multiple sensor units are arranged in the catheter assembly, and each sensor unit is respectively used to detect different types of biometric signals; wherein, a detection window is arranged on the side wall of the catheter assembly for the exposed sensor units.

[0009] Optionally, in the above implantable sensor packaging structure, the catheter assembly includes:

[0010] At least one section of tubular protection frame, and the tube wall of the protection frame has an opening for forming the detection window;

[0011] A support member located inside the protection frame, the support member is used to support the tube wall of the protection frame and is also used to carry the sensor units.

[0012] Optionally, in the above implantable sensor packaging structure, the support member is a flat plate structure, and the plane where the flat plate structure is located is parallel to one inner diameter direction of the protection frame;

[0013] Wherein, one sensor unit is arranged on each of the two opposite surfaces of the flat plate structure.

[0014] Optionally, in the above-mentioned implantable sensor packaging structure, the support member is a flat structure, including at least two sections of protection frames, and the planes where the flat structures in two adjacent protection frames are located intersect.

[0015] Optionally, in the above-mentioned implantable sensor packaging structure, in the same support member, the support member includes a plurality of flat structures;

[0016] In the same support member, the planes where each flat structure is located are respectively parallel to one inner diameter direction of the protection frame, and the flat structures intersect in the protection frame to form a plurality of fan-shaped partitions, and the sensor units are located in the fan-shaped partitions; each sensor unit is located in a different fan-shaped partition.

[0017] Optionally, in the above-mentioned implantable sensor packaging structure, in the same support member, the central angles of the plurality of fan-shaped partitions are the same, each fan-shaped partition is correspondingly provided with a sensor unit, and the catheter assembly is correspondingly provided with a detection window for each fan-shaped partition;

[0018] Or, in the same support member, the plurality of fan-shaped partitions include a plurality of alternately arranged first fan-shaped partitions and second fan-shaped partitions, the first fan-shaped partitions are used to arrange the sensor units, and the second fan-shaped partitions are used to arrange the signal lines connected to the sensor units.

[0019] Optionally, in the above-mentioned implantable sensor packaging structure, the catheter assembly includes a plurality of sections of protection frames corresponding one-to-one with the sensor units, and a sensor unit is respectively and correspondingly arranged in each protection frame;

[0020] In the length direction of the catheter assembly, the protection frames are arranged in sequence.

[0021] Optionally, in the above-mentioned implantable sensor packaging structure, it further includes an outer tube covering the protection frame, and the outer tube has an opening exposing the detection window;

[0022] Or, along the length direction of the catheter assembly, the catheter assembly includes a plurality of sections of protection frames arranged in sequence, and there is a section of insulating tube between adjacent protection frames, and the insulating tube is used to pass the signal lines connected to the sensor units and is used to fill the colloid for bonding and fixing the protection frames;

[0023] Or, the tube wall of the protection frame has at least one glue injection hole, and the glue injection hole is used for injecting colloid;

[0024] Or, the protection frame is one of a titanium alloy frame and a ceramic frame.

[0025] Optionally, in the above-mentioned implantable sensor packaging structure, the plurality of sensor units include at least two of a pressure detection unit, a temperature detection unit, a pH detection unit, and an oxygen partial pressure detection unit;

[0026] Alternatively, one of the multiple sensor units is a pressure detection unit, and the pressure detection unit includes a pressure sensor chip; a pressure detection area of the pressure sensor chip is covered with a pressure-sensitive protection film; a pressure chip coating is covered on a surface of the pressure-sensitive protection film;

[0027] Alternatively, a protection layer is covered on a surface of the sensor unit;

[0028] Alternatively, one of the multiple sensor units is a pH detection unit, and the pH detection unit includes a pH sensor chip and a pH working electrode connected to the pH sensor chip, and the pH working electrode includes a glass membrane sensitive to hydrogen ions;

[0029] Alternatively, one of the multiple sensor units is an oxygen partial pressure detection unit, and a hydrogel protection layer or a silicone rubber protection layer is covered on a surface of the oxygen partial pressure detection unit.

[0030] A second aspect of the present application provides a biometric signal acquisition system, including:

[0031] The implantable sensor packaging structure according to any one of the above;

[0032] An external monitor, and the external monitor is communicatively connected to the implantable sensor packaging structure.

[0033] By means of the above technical solution, in the implantable sensor packaging structure provided by the present application, the catheter assembly integrates multiple sensor units for detecting different types of biometric signals, a detection window for exposing the sensor units is provided on a side wall of the catheter assembly, and each sensor unit can collect biometric signals based on the corresponding detection window, and a same implantable sensor packaging structure can collect multiple biometric signals simultaneously. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the related art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the drawings in the following description are only the embodiments of the present application. For those of ordinary skill in the art, other drawings can be obtained according to the provided drawings without creative efforts.

[0035] The structures, ratios, sizes, etc. shown in the drawings of this specification are only used to cooperate with the content disclosed in the specification for those who are familiar with this technology to understand and read, and are not used to limit the limiting conditions that can be implemented by the present application. Therefore, they do not have technical essence. Any modification of the structure, change of the proportional relationship or adjustment of the size should still fall within the scope covered by the technical content disclosed in the present application without affecting the effects that the present application can produce and the purposes that can be achieved.

[0036] Figure 1Schematic diagram of an implantable sensor packaging structure provided by an embodiment of the present application;

[0037] Figure 2 Top view of an implantable sensor packaging structure provided by an embodiment of the present application in a section of the protection frame;

[0038] Figure 3 For Figure 2 Structure of the implantable sensor packaging structure shown along the P-P' section;

[0039] Figure 4 Section view of an implantable sensor packaging structure provided by an embodiment of the present application in a section of the protection frame;

[0040] Figure 5 Section view of an implantable sensor packaging structure provided by an embodiment of the present application in another section of the protection frame;

[0041] Figure 6 Section view of an implantable sensor packaging structure provided by an embodiment of the present application in yet another section of the protection frame;

[0042] Figure 7 Section view of an implantable sensor packaging structure provided by an embodiment of the present application in yet another section of the protection frame;

[0043] Figure 8 Partial top view of a catheter assembly provided by an embodiment of the present application;

[0044] Figure 9 For Figure 1 Top view of the pressure detection unit in the implantable sensor packaging structure shown;

[0045] Figure 10 For Figure 9 Exploded view of the pressure detection unit shown;

[0046] Figure 11 For Figure 1 Top view of the temperature detection unit in the implantable sensor packaging structure shown;

[0047] Figure 12 For Figure 1 Top view of the pH detection unit in the implantable sensor packaging structure shown;

[0048] Figure 13 For Figure 1 Top view of the oxygen partial pressure detection unit in the implantable sensor packaging structure shown;

[0049] Figure 14 Schematic diagram of the structure of a biometric signal acquisition system provided by an embodiment of the present application.

[0050] Reference numerals:

[0051] 100 - Implantable sensor packaging structure; 101 - Pressure detection unit; 102 - Temperature detection unit; 103 - pH detection unit; 104 - Oxygen partial pressure detection unit; 105 - Catheter assembly; 106 - Base; 107 - Sensor unit; 108 - Detection window; 109 - Protection frame; 110 - Support; 111 - Accommodating space; 112 - Signal line; 113 - Insulating tube; 114 - Glue injection hole; 115 - External monitor; 1011 - Probe plug; 1012 - Pressure sensor chip; 1013 - Pressure - sensitive protective film; 1014 - Pressure chip metal protection frame; 10141 - Metal frame through - hole; 10142 - Metal frame opening; 1015 - Pressure chip enameled wire; 1016 - Pressure chip coating; 1021 - Temperature sensor chip; 1022 - Temperature chip protective shell; 1023 - Connection lead; 1024 - Temperature chip enameled wire; 1025 - Temperature chip coating; 1026 - Temperature chip metal protection frame; 1031 - pH sensor chip; 10311 - Pad; 10312 - pH reference electrode; 10313 - pH working electrode; 10314 - pH electrode lead; 1032 - pH chip enameled wire; 1033 - pH chip coating; 1034 - pH electrode protective layer; 1035 - pH chip metal protection frame; 1041 - Oxygen sensor chip; 10411 - Pad; 10412 - Oxygen reference electrode; 10413 - Oxygen counter electrode; 10414 - Oxygen working electrode; 10415 - Oxygen electrode lead; 1042 - Oxygen chip enameled wire; 1043 - Oxygen chip coating; 1044 - Oxygen electrode protective layer; 1045 - Oxygen chip metal protection frame. Detailed implementation manners

[0052] Next, the embodiments in the present application will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present application. Those of ordinary skill in the art will know that with the development of technology and the emergence of new scenarios, the technical solutions provided in the embodiments of the present application are also applicable to similar technical problems.

[0053] Intracranial monitoring technology refers to the technology of real - time monitoring of physiological, biochemical or electrophysiological parameters in the cranial cavity through invasive or non - invasive means, mainly used for neuro - critical care, epilepsy surgery evaluation and brain function research. Clinically, traditional monitoring technologies, such as electroencephalogram (EEG), intracranial pressure (ICP) monitoring, cerebral oxygen saturation, cerebral blood flow assessment, etc., have provided great help to clinicians in clinical decision - making and intervention.

[0054] Continuous and comprehensive intracranial monitoring is crucial for timely identifying changes or deterioration in brain function, enabling timely intervention and personalized treatment. Therefore, intracranial monitoring has been continuously evolving from single-modal to multi-modal. Intracranial multi-modal monitoring is a technology that comprehensively evaluates the brain function state by simultaneously collecting and analyzing multiple physiological, biochemical, and electrophysiological parameters in the cranial cavity. Its core goal is to integrate complementary data, break through the limitations of single monitoring, and improve the understanding of the brain injury mechanism and the accuracy of clinical intervention. However, existing intracranial multi-modal monitoring technologies mostly use independent sensors to separately monitor different biometric signals, requiring multiple implantable sensors for collecting different biometric signals to be implanted through multiple catheters. Multiple catheter implantations result in large implantation trauma, high infection risk, and are unable to perform long-term continuous monitoring.

[0055] To solve the above problems, an embodiment of the present application provides an implantable sensor packaging structure, including:

[0056] A base;

[0057] A catheter assembly fixed on one side surface of the base;

[0058] Multiple sensor units are arranged in the catheter assembly, and each sensor unit is respectively used to detect different types of biometric signals; wherein, a detection window is provided on the side wall of the catheter assembly, and the detection window is used to expose the sensor unit.

[0059] In the embodiment of the present application, the catheter assembly in the implantable sensor packaging structure integrates multiple sensor units for detecting different types of biometric signals, and a detection window for exposing the sensor unit is provided on the side wall of the catheter assembly. Each sensor unit can collect biometric signals based on the corresponding detection window. It can be seen that the same implantable sensor packaging structure can simultaneously collect multiple biometric signals.

[0060] Since multiple sensor units for collecting different biometric signals are simultaneously integrated in the same catheter assembly in the implantable sensor packaging structure, the implantable sensor packaging structure is an integrated sensor with a single catheter and multiple detection windows, which can reduce implantation trauma, lower the infection risk, can perform long-term continuous monitoring, and can improve the monitoring efficiency.

[0061] It should be noted that in the embodiment of the present application, the collection of intracranial biometric signals is taken as an example for illustration. It is easy to know that the implantable sensor packaging structure in the embodiment of the present application is not limited to the collection of intracranial biometric signals, and can also be used for the collection of biometric signals in other parts, such as for the collection of biometric signals in the abdominal cavity or thoracic cavity, etc. The application scenario of the implantable sensor packaging structure in the embodiment of the present application is not limited.

[0062] To make the above objects, features, and advantages of the present application more apparent and understandable, the present application will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0063] Reference Figure 1 , Figure 1 FIG. is a schematic diagram of an implantable sensor packaging structure provided by an embodiment of the present application. The implantable sensor packaging structure 100 shown includes:

[0064] A base 106;

[0065] A catheter assembly 105 fixed on one side surface of the base 106;

[0066] A plurality of sensor units 107 are provided in the catheter assembly 105, and each sensor unit 107 is respectively used to detect different types of biometric signals; wherein, a detection window 108 is provided on the side wall of the catheter assembly 105, and the detection window 108 is used to expose the sensor unit 107.

[0067] The catheter assembly 105 in the implantable sensor packaging structure 100 integrates a plurality of sensor units 107 for detecting different types of biometric signals. A detection window 108 for exposing the sensor unit 107 is provided on the side wall of the catheter assembly 105. Each sensor unit 107 can collect biometric signals based on the corresponding detection window 108. Therefore, the implantable sensor packaging structure 100 is an integrated sensor with a single catheter and multiple detection windows, and the same implantable sensor packaging structure 100 can collect multiple biometric signals simultaneously, realizing miniaturization and multimodal detection.

[0068] On the basis of other embodiments, in one embodiment, as Figure 1 shown, a section of the catheter assembly 105 away from the base 106 includes a probe plug 1011. The area of the catheter assembly 105 close to the probe plug 1011 is a detection area for arranging a plurality of sensor units 107. The other end of the catheter assembly 105 is fixedly connected to the base 106. The base 106 includes a housing, a circuit board, and a battery located inside the housing. The circuit board includes a signal processing circuit. The housing of the base 106 is used to protect the battery for power supply and the circuit board for signal processing inside it.

[0069] Optionally, the material of the housing of the base 106 is preferably PEEK (polyetheretherketone) or ceramic material with good biocompatibility, good corrosion resistance, and hard texture.

[0070] Among them, the implantable sensor packaging structure 100 is a staple structure, and the diameter of the catheter assembly 105 is smaller than the width of the base 106. The catheter assembly 105 is the in-vivo implant part. If it is used for intracranial signal acquisition, at least the detection areas of each sensor unit 107 provided on the catheter assembly 105 can be implanted into the brain tissue.

[0071] In an implementation manner of the embodiment of the present application, multiple sensor units 107 are arranged in sequence in the length direction of the catheter assembly 105. In this way, multiple different sensor units 107 are arranged in sequence on the same straight line, which can make the product have a higher integration degree, and can also make the catheter assembly 105 have a smaller diameter, reducing the implantation trauma.

[0072] Among them, the surface packaging material of the implantable sensor packaging structure 100 can adopt biocompatible materials such as polyurethane, nylon, parylene, epoxy resin, silicone rubber, titanium alloy, and ceramic, improving the biocompatibility of the product and being beneficial to the long-term continuous monitoring of the implantable sensor. Moreover, the sensor unit 107 can adopt a multi-layer sealing structure to ensure the sealing performance and reliability of the sensor unit 107, improving the long-term stability of each sensor unit 107 and being beneficial to its long-term continuous monitoring.

[0073] Optionally, multiple sensor units 107 in the implantable sensor packaging structure 100 include at least two of a pressure detection unit 101, a temperature detection unit 102, a pH detection unit 103, and an oxygen partial pressure detection unit 104. Among them, the pressure detection unit 101 can be used to detect the pressure in the living body, the temperature detection unit 102 can be used to detect the temperature in the living body, and the pH detection unit 103 can be used to detect the pH value in the living body.

[0074] In Figure 1 In the shown manner, taking the implantable sensor packaging structure 100 including four sensor units 107 as an example for illustration, the four sensor units 107 can be sequentially a pressure detection unit 101, a temperature detection unit 102, a pH detection unit 103, and an oxygen partial pressure detection unit 104. If the implantable sensor packaging structure 100 is used for intracranial information acquisition, it can effectively monitor intracranial pressure, temperature, oxygen partial pressure, and pH value. Based on these biometric signals, it can be used for the clinical monitoring of various brain diseases, such as providing dynamic data support for clinical scenarios of brain diseases such as brain trauma, hydrocephalus, and brain tumors.

[0075] It should be noted that the implantable sensor packaging structure 100 is not limited to brain disease monitoring, and can also be used for disease monitoring at positions such as the human abdominal cavity and thoracic cavity. The embodiment of the present application does not limit the application scenarios of the implantable sensor packaging structure 100.

[0076] If the implantable sensor package structure 100 includes a pressure detection unit 101, a temperature detection unit 102, a pH detection unit 103, and an oxygen partial pressure detection unit 104 at the same time, and the four sensor units 107 are arranged in sequence along the length direction of the catheter assembly 105, the arrangement order of the four sensor units 107 can be arranged according to requirements, not limited to Figure 1 the manner shown.

[0077] Based on the above description, compared with the multi-catheter implantation scheme in which multiple different sensors are individually packaged, the implantable sensor chip package structure provided by the embodiments of the present application integrates multiple different sensor units 107 on the same catheter assembly 105 at the same time. The technical solutions of the embodiments of the present application have the advantages of high integration and small wound surface. The catheter assembly 105 can also be prepared from a material with good biocompatibility, so that the implantable sensor package structure 100 has the advantage of good biocompatibility.

[0078] The multiple sensor units 107 in the implantable sensor package structure 100 can include any two, or any three, or all four of the pressure detection unit 101, the temperature detection unit 102, the pH detection unit 103, and the oxygen partial pressure detection unit 104. In other ways, the multiple sensor units 107 in the implantable sensor package structure 100 can also include other types of sensor units, such as any one of sensors such as a blood glucose detection unit, a lactic acid detection unit, a neurotransmitter detection unit, an inflammation marker detection unit, and a tumor marker detection unit.

[0079] If each sensor unit 107 is as Figure 1 shown and arranged in sequence along the length direction of the catheter assembly 105, each sensor unit 107 is respectively provided with a detection window 108, and the detection windows 108 can have the same orientation, that is, the detection windows 108 are located in the same plane, so as to facilitate the process preparation of the catheter assembly 105. In other ways, if each sensor unit 107 is as Figure 1 shown and arranged in sequence along the length direction of the catheter assembly 105, at least two detection windows 108 can also be set to have different orientations, so as to balance the side wall stress of the catheter assembly 105 and prevent the catheter assembly from bending due to uneven stress.

[0080] In the implantable sensor package structure 100, each sensor unit 107 is not limited to using Figure 1In the linear arrangement shown, in other embodiments, at least two sensor units 107 can also be provided on the catheter assembly 105 to have the same height position relative to the base 106. In this way, the length of the detection area in the catheter assembly 105 can be reduced to reduce the implantation depth of the detection area. Among them, the detection area is the area where each sensor unit 107 is integrated in the catheter assembly 105.

[0081] Based on other embodiments, in one embodiment, one of the multiple sensor units 107 is a pressure detection unit 101. The pressure detection unit 101 includes a pressure sensor chip; a pressure detection area of the pressure sensor chip is covered with a pressure-sensitive protection film; a pressure chip coating is covered on the surface of the pressure-sensitive protection film. This method can achieve multi-layer sealing protection of the pressure sensor chip through the laminated pressure-sensitive protection film and pressure chip coating, can ensure the sealing performance and reliability of the pressure detection unit 101, improve its long-term stability, and is conducive to long-term continuous monitoring.

[0082] The pressure detection unit 101 adopts the sealing protection of the pressure-sensitive protection film and the pressure chip coating. Combining with the protection frame 109 in the following embodiments, three-level protection can be achieved, which can greatly improve the sealing performance and reliability of the pressure detection unit 101.

[0083] Optionally, not limited to the pressure detection unit 101 adopting multi-layer sealing protection, a protection film and a chip coating can be covered on the surface of each sensor unit 107. The sensor unit 107 adopting multi-layer sealing protection can ensure the sealing performance and reliability of the sensor unit 107, improve its long-term stability, and is conducive to long-term continuous monitoring.

[0084] Based on other embodiments, in one embodiment, a protective layer is covered on the surface of the sensor unit 107; the protective layer can include a protection film covering the chip detection area and a chip coating covering the protection film, so that the sensor unit 107 realizes multi-layer sealing protection.

[0085] Based on other embodiments, in one embodiment, one of the multiple sensor units 107 is a pH detection unit. The pH detection unit includes a pH sensor chip and a pH working electrode connected to the pH sensor chip. The pH working electrode includes a glass membrane sensitive to hydrogen ions. The silicon-oxygen network structure of the glass membrane contains migratable alkali metal ions. When the membrane surface contacts the solution, these ions exchange ions with hydrogen ions in the solution to form a hydrogen ion-sensitive hydrated gel layer. Based on this mechanism, the glass film has an extremely low selectivity coefficient for hydrogen ions, is hardly interfered by other cations, has high selectivity for hydrogen ions, and is suitable for pH measurement in the complex ionic environment of tissue fluids such as human blood. In addition, the pH electrode based on the glass membrane can cover the full range of pH values from 0 to 14. Under extreme pH conditions, the glass membrane can still maintain a stable response without the risk of material corrosion or membrane structure collapse. Moreover, the glass membrane has strong chemical inertness, resists organic solvents, oxidants, and weakly corrosive media, and has a long service life.

[0086] Based on other embodiments, in one embodiment, one of the multiple sensor units 107 is an oxygen partial pressure detection unit. The surface of the oxygen partial pressure detection unit is covered with a hydrogel protective layer or a silicone rubber protective layer, which can be used for short-term protection and long-term protection of the oxygen partial pressure detection unit respectively. For short-term detection, a hydrogel material with excellent oxygen permeability and slight immune rejection reaction can be used; for long-term detection, a silicone rubber material with excellent oxygen permeability, corrosion resistance, and anti-aging can be used.

[0087] Reference Figure 2 and Figure 3 , Figure 2 FIG. is a top view of an implantable sensor encapsulation structure provided by an embodiment of the present application in a section of the protection frame. Figure 3 is Figure 2 the structure of the implantable sensor encapsulation structure shown along the P-P' section. The length direction of the catheter assembly 105 is set as the first direction F. Figure 3 The shown section is perpendicular to the first direction F. Based on other embodiments, Figure 2 and Figure 3 In the implantable sensor encapsulation structure 100 shown, the catheter assembly 105 includes: at least one tubular protection frame 109, and the tube wall of the protection frame 109 has an opening for forming a detection window 108; a support member 110 located inside the protection frame 109, and the support member 110 is used to support the tube wall of the protection frame 109 and also used to carry the sensor unit 107. In this way, it is set that Figure 2 and Figure 3 the plane where the sensor unit 107 is located shown is parallel to the first radial direction R1 of the protection frame 109. The first radial direction R1 is the length direction of an inner diameter of the protection frame 109.

[0088] In one embodiment based on other embodiments, the protective frame 109 is one of a titanium alloy frame and a ceramic frame. At this time, the protective frame 109 not only has good biocompatibility but also has good mechanical strength.

[0089] In Figure 2 and Figure 3 In the manner shown, the two side walls of the support member 110 on the first radial direction R1 are respectively in contact with the inner wall of the protective frame 109. It can not only support the tube wall of the protective frame 109 to prevent the tubular protective frame 109 from deforming inwards, but also the support member 110 can serve as a carrier plate for the sensor unit 107 to carry the sensor unit 107 so that the sensor unit 107 can face the corresponding detection window 108.

[0090] Referring to Figure 4 , Figure 4 which is a cross-sectional view of an implantable sensor package structure provided by an embodiment of the present application in a section of the protective frame. The plane where the flat structure is located is parallel to an inner diameter direction (such as Figure 4 the first radial direction R1 in

[0091] ) of the protective frame 109. Among them, one sensor unit 107 is respectively arranged on two opposite surfaces of the flat structure. A detection window 108 is respectively arranged on the tube wall of the section of the protective frame 109 corresponding to the two sensor units 107 so that the two sensor units 107 can respectively collect biometric signals based on the corresponding detection windows 108. In this way, the two sensor units 107 can be simultaneously carried by the support member 110 of the same flat structure, and one sensor unit 107 is respectively arranged on two opposite surfaces of the support member 110, which can reduce the length of the catheter assembly 105 in the first direction F and can reduce the length of the detection area in the catheter assembly 105. Figure 2 and Figure 3 Optionally, in the manner shown in

[0092] Referring to Figure 5 , Figure 5 which is a cross-sectional view of an implantable sensor package structure provided by an embodiment of the present application in another section of the protective frame, Figure 5 the cross-section shown is perpendicular to the first direction F. Figure 5 The section of the protective frame 109 shown in Figure 4The shown section of the protection frame 109 can be two end protection frames 109 adjacent in the first direction F. Figure 5 In the shown protection frame 109, the plane where the flat structure of the support member 110 is located is parallel to the second radial direction R2, and the second radial direction R2 is the length direction of an inner diameter of the protection frame 109.

[0093] Combined Figure 4 and Figure 5 As shown, in one embodiment, it includes at least two sections of protection frames 109. The planes where the flat structures in two adjacent protection frames 109 are located intersect, that is, the first radial direction R1 and the second radial direction R2 intersect. This way can make the flat structures in two adjacent sections of protection frames 109 abut against the inner wall of the protection frame 109 along different radial directions respectively, so as to balance the effects of each flat structure acting on the catheter assembly 105 in the first direction F, and better prevent the problem of the side wall from being dented.

[0094] Optionally, it can be set that the planes where the flat structures in two adjacent protection frames are located are perpendicular, that is, the first radial direction R1 and the second radial direction R2 are perpendicular.

[0095] It should be noted that if the support member 110 is a flat structure, when the flat structures in two adjacent protection frames 109 intersect, it is not limited to Figure 4 and Figure 5 shown that a sensor unit 107 is respectively arranged on the opposite surfaces of each flat structure. Any flat structure can be provided with a sensor unit 107 on one side, or can be provided with a sensor unit 107 on both sides respectively. The embodiments of the present application do not make any limitations in this regard.

[0096] Refer to Figure 6 , Figure 6 which is a sectional view of an implantable sensor packaging structure provided by an embodiment of the present application in another section of the protection frame. Figure 6 The shown section is perpendicular to the first direction F. On the basis of other embodiments, Figure 6 in the shown way, for the same support member 110, the support member 110 includes a plurality of flat structures.

[0097] As Figure 6 shown, in the same support member 110, the planes where the respective flat structures are located are respectively parallel to an inner diameter direction of the protection frame 109, and the respective flat structures cross in the protection frame 109 to form a plurality of fan-shaped partitions, and the sensor units 107 are located in the fan-shaped partitions; the respective sensor units 107 are located in different fan-shaped partitions. In Figure 6In the illustrated manner, taking the support member 110 including two flat plate structures as an example for illustration, the two flat plate structures intersect at the center of the cross-section of the protection frame 109. In this manner, multiple sensor units 107 can be simultaneously arranged in the same protection frame 109, the length of the catheter assembly 105 in the first direction F can be reduced, and the length of the detection area in the catheter assembly 105 can be reduced. Moreover, since the support member 110 includes multiple intersecting flat plate structures, in the same section of the protection frame 109, the support member 110 can provide a more uniform supporting force for the inner wall of the protection frame 109.

[0098] In one implementation manner of the embodiments of the present application, in the same section of the protection frame 109, each sector partition can be respectively provided with a sensor unit 107. As Figure 6 shown, if the support member 110 includes two flat plate structures, four sector partitions can be formed, and each sector partition is provided with a sensor unit 107, then four sensor units 107 can be simultaneously arranged in a section of the protection frame 109.

[0099] Optionally, in the same section of the protection frame 109, if each sector partition is respectively provided with a sensor unit 107, the catheter assembly 105 is respectively provided with a detection window 108 corresponding to each sector partition, so that the sensor unit 107 in each sector partition can collect biometric signals based on the corresponding detection window 108, and the same support member 110 can be provided with multiple sector partitions having the same central angle.

[0100] In the same support member 110, when each sector partition is respectively provided with a sensor unit 107, it can be as Figure 6 shown, each sensor unit 107 forms an accommodation space 111 with the central angle of the sector partition where it is located, the signal line 112 connected to the sensor unit 107 can be located in the accommodation space 111 formed by itself, and the signal line 112 passes through the accommodation space 111 where it is located and is connected to the circuit board in the base 106.

[0101] In one implementation manner, it can be set that the implantable sensor packaging structure 100 arranges all the sensor units 107 through a section of the protection frame 109. By providing a support member 110 formed by multiple intersecting flat plate structures, and each sector partition is provided with a sensor unit 107, all the sensor units 107 can be integrated in the same section of the protection frame 109, thereby minimizing the length of the catheter assembly 105 in the first direction F and minimizing the length of the detection area in the catheter assembly 105.

[0102] In one implementation manner, it can be set that the implantable sensor packaging structure 100 includes at least two sections of the protection frame 109, and the support member 110 in one of the protection frames 109 is asFigure 6 As shown, the support member 110 in the other protection frame 109 can be as Figures 2 - 6 shown in any one of the ways.

[0103] Referring to Figure 7 , Figure 7 FIG. is a sectional view of an implantable sensor packaging structure provided by an embodiment of the present application in another protection frame, Figure 7 The shown section is perpendicular to the first direction F. On the basis of other embodiments, Figure 7 In the shown way, the support member 110 includes a plurality of flat structures, and a plurality of fan-shaped partitions formed by the intersection of each flat structure. For the same support member 110, the plurality of fan-shaped partitions include a plurality of alternately arranged first fan-shaped partitions and second fan-shaped partitions. The first fan-shaped partition is used to arrange the sensor unit 107, and the second fan-shaped partition is used to arrange the signal line 112 connected to the sensor unit 107.

[0104] In Figure 7 the shown way, the sensor unit 107 and the connected signal line 112 are respectively located in the first fan-shaped partition and the second fan-shaped partition, which can avoid interference between the sensor unit 107 and the signal line 112. Each first fan-shaped partition is correspondingly provided with a sensor unit 107, and the signal lines 112 connected to different sensor units 107 are respectively located in different second fan-shaped partitions to avoid interference between the signal lines 112 connected to different sensor units 107.

[0105] Optionally, in order to facilitate the connection between the sensor unit 107 and the signal line 112 connected thereto, the sensor unit 107 and the signal line 112 connected thereto are respectively arranged in adjacent first fan-shaped partition and second fan-shaped partition.

[0106] In one embodiment, as Figure 7 shown, the central angle of the first fan-shaped partition is set as B1, and the central angle of the second fan-shaped partition is set as B2, and B1 is greater than B2. In this way, the first fan-shaped partition can have a larger area ratio to ensure a sufficient area ratio of sensor detection, and improve the intensity and accuracy of signal acquisition.

[0107] In one embodiment, based on other embodiments, the implantable sensor encapsulation structure 100 further includes an outer tube covering the protection frame 109, and the outer tube has an opening exposing the detection window 108. This method can integrally protect the catheter assembly 105 through the integrally formed outer tube, which is integrally wrapped outside the catheter assembly 105, and can improve the mechanical strength of the catheter assembly 105. Optionally, the outer tube can be a thermoplastic biocompatible material, which can not only improve the mechanical strength and biocompatibility of the product, but also be closely attached to the outer surface of the catheter assembly 105 through heat shaping treatment to improve its attachment stability on the surface of the catheter assembly 105.

[0108] Reference Figure 8 , Figure 8 FIG. is a partial top view of a catheter assembly provided by an embodiment of the present application. Along the length direction (the first direction F) of the catheter assembly 105, the catheter assembly 105 includes multiple sections of protection frames 109 arranged in sequence. There is an insulating tube 113 between adjacent protection frames 109. The insulating tube 113 is used to pass through the signal line connected to the sensor unit 107 and is used to fill the colloid for bonding and fixing the protection frame 109. In this way, the end-to-end connection and fixation of adjacent protection frames 109 can be realized through the insulating tube 113 between adjacent protection frames 109.

[0109] Optionally, as Figure 8 shown, the tube wall of the protection frame 109 has at least one glue injection hole 114, and the glue injection hole 114 is used for injecting colloid. After the sensor unit 107 is assembled inside the catheter assembly 105 and the connection between the sensor unit 107 and the circuit board in the base 106 is realized, based on the injected colloid, the colloid filling of the internal space of the catheter assembly 105 can be realized to improve the bonding and fixing of the internal structural members and improve the structural stability.

[0110] In an embodiment of the present application, in one embodiment, the catheter assembly 105 can be provided to include multiple sections of protection frames 109 corresponding to the sensor unit 107 one by one, and a sensor unit 107 is respectively arranged in each protection frame 109; in the length direction of the catheter assembly 105, the protection frames 109 are arranged in sequence. At this time, the implantable sensor encapsulation structure 100 can be as Figure 1 shown.

[0111] Taking Figure 1 the structure shown as an example, the multiple sensor units 107 in the implantable sensor encapsulation structure 100 include a pressure detection unit 101, a temperature detection unit 102, a pH detection unit 103, and an oxygen partial pressure detection unit 104 arranged in sequence in the length direction of the catheter assembly 105. Based on Figure 1 the method shown, the structures of these four sensor units 107 will be described.

[0112] The pressure detection unit 101, the temperature detection unit 102, the pH detection unit 103, and the oxygen partial pressure detection unit 104 constitute the detection area of the implantable sensor package structure 100.

[0113] Reference Figure 9 and Figure 10 , Figure 9 is Figure 1 the top view of the pressure detection unit in the implantable sensor package structure shown, Figure 10 is Figure 9 the exploded view of the pressure detection unit shown. The pressure detection unit 101, as Figure 1 the first detection area in the scheme shown, includes: a pressure sensor chip 1012, a pressure-sensitive protective film 1013, a pressure chip metal protection frame 1014, a pressure chip enameled wire 1015, and a pressure chip coating 1016.

[0114] Among them, the probe plug 1011 is located at one end of the pressure detection unit 101 away from the base 106. The probe plug 1011 is hemispherical in shape, which can reduce the implantation resistance and is used to enable the implantable sensor package structure 100 to smoothly pass through biological tissues to reach the designated implantation position and protect the pressure sensor chip 1012. If used for intracranial information acquisition, Figure 1 the structure shown can be implanted into the brain tissue through a craniotomy with four sensor units 107 and the connected catheter assembly 105, and the base 106 can be fixed between the scalp and the skull. The material of the probe plug 1011 is an epoxy resin material with a relatively hard texture and high biocompatibility. The pressure sensor chip 1012 is the core device for pressure. The pressure-sensitive protective film 1013 is used to protect the pressure-sensitive film and piezoresistor on the surface of the pressure sensor chip 1012. The pressure-sensitive protective film 1013 can be made of parylene material with high biocompatibility, good moisture-proof and waterproof performance, chemical corrosion resistance, and high insulation.

[0115] The pressure chip metal protection frame 1014 is used to protect the pressure sensor chip 1012 and support the pressure detection unit 101. A metal frame through hole 10141 (i.e., the injection hole 114 provided on the pressure chip metal protection frame 1014) is provided on the pressure chip metal protection frame 1014. Further, the metal frame through hole 10141 and the detection window of the pressure detection unit 101 face the same direction on the pressure chip metal protection frame 1014 and are used as the glue injection inlet for bonding the adjacent two protection frames 109, and the number is at least 1.

[0116] The pressure chip metal protection frame 1014 is provided with a metal frame opening 10142 (for forming the detection window 108 of the pressure detection unit 101). The metal frame opening 10142 is used to expose the pressure sensor chip 1012, and can conduct the external pressure to the surface of the pressure sensor chip 1012, and its area is larger than that of the pressure sensitive film. The pressure chip metal protection frame 1014 can be made of materials such as titanium, titanium alloy, and stainless steel with high biocompatibility, hard texture, and corrosion resistance.

[0117] The enameled wire 1015 of the pressure chip is led out from the electrodes of the pressure sensor chip 1012, and sequentially passes through the pressure chip metal protection frame 1014, the insulating tube 113 and the subsequent detection area, and is finally electrically connected to the signal processing circuit board inside the base 106. Further, the enameled wire 1015 of the pressure chip is multi-stranded, and the number of strands is determined according to the number of chips and the corresponding number of electrodes used.

[0118] The pressure chip coating 1016 is used to protect the surface of the pressure sensor chip 1012 and fix the pressure sensor chip 1012 on the pressure chip metal protection frame 1014. In order not to affect the pressure transmission to the pressure sensor chip 1012 as much as possible, the pressure chip coating 1016 can be made of silicone rubber material with high biocompatibility, density, insulation and high elasticity.

[0119] The encapsulation method of the pressure detection unit 101 includes: First, deposit the pressure sensitive protective film 1013 on the pressure sensitive area of the pressure sensor chip 1012 by chemical vapor deposition; then, press-weld the enameled wire 1015 of the pressure chip to the four electrodes of the pressure sensor chip 1012; further, position the pressure sensor chip 1012 in the opening area of the pressure chip metal protection frame 1014; further, pour the pressure chip coating material (such as silicone rubber) through the metal frame through hole 10141; further, coat the material of the probe plug 1011 (such as epoxy resin); finally, perform stepwise curing, pre-cure at 80 °C for 2 h, and then cure at 120 °C for 4 h. After encapsulation, pressure calibration needs to be carried out at 0 mmHg to 50 mmHg with a gradient of 5 mmHg. Among them, the size of the probe plug 1011 is small, and a hemispherical or semi-ellipsoidal structure can be formed through the coating process and the natural surface tension of the material.

[0120] Reference Figure 11 , Figure 11 is Figure 1 the top view of the temperature detection unit in the implantable sensor encapsulation structure shown. The temperature detection unit 102 is used as Figure 1 the second detection area in the scheme shown, and includes: a temperature sensor chip 1021, a temperature chip protection shell 1022, a connection lead 1023, a temperature chip enameled wire 1024, a temperature chip coating 1025, and a temperature chip metal protection frame 1026.

[0121] Among them, the temperature sensor chip 1021 is the core device for detecting temperature and can be an NTC thermistor. The temperature chip protective case 1022 is used to protect the temperature sensor chip 1021 and conduct heat with the external environment, and a ceramic material with good thermal conductivity and insulation can be used. The connection lead 1023 is used to connect the temperature sensor chip 1021 and the temperature chip enameled wire 1024, and materials such as platinum and gold with good conductivity and ductility can be used. The temperature chip coating 1025 is used to protect the temperature sensor chip 1021, the connection lead 1023 and the temperature chip enameled wire 1024, and an epoxy resin material with high biocompatibility and insulation can be used.

[0122] The encapsulation method of the temperature detection unit 102 includes: First, use pressure welding to connect the temperature sensor chip 1021, the connection lead 1023, and the temperature chip enameled wire 1024 in sequence; then, nest the temperature sensor chip 1021 into the temperature chip protective case 1022; further, position the temperature sensor chip 1021 in the window area of the temperature chip metal protective frame 1026; further, apply the temperature chip coating 1025 on the surface; finally, perform thermal curing and cure at 100 °C for 5 h. After encapsulation, temperature calibration needs to be carried out at 20 °C to 50 °C in 5 °C gradients.

[0123] Reference Figure 12 , Figure 12 is Figure 1 the top view of the pH detection unit in the implantable sensor encapsulation structure shown. The pH detection unit 103 is the third detection area in the Figure 1 scheme shown, and includes: a pH sensor chip 1031, a pH chip enameled wire 1032, a pH chip coating 1033, a pH electrode protective layer 1034, and a pH chip metal protective frame 1035. Among them, the pH sensor chip 1031 is the core device for detecting pH, and it includes: pads 10311, a pH reference electrode 10312, a pH working electrode 10313, and a pH electrode lead 10314. The pH working electrode 10313 is made of a glass membrane and is sensitive to hydrogen ions (H + ); the pH reference electrode 10312 is used to provide a stable reference potential, and the pH reference electrode 10312 can be an Ag / AgCl electrode and is not affected by the solution pH.

[0124] The pH electrode lead 10314 connects the two electrodes to the two pads 10311 respectively. The enameled wire 1032 of the pH chip is connected to the pad 10311 by thermocompression bonding to transmit the output of the pH sensor chip to the circuit board at the tail of the probe for signal processing. The pH chip coating 1033 is used to protect the enameled wire 1032 of the pH chip, the pad 10311 and the pH electrode lead 10314, and an epoxy resin material with good biocompatibility and insulation can be used. The pH electrode protective layer 1034 is used to ensure the stability of the electrode in the detection environment. Polytetrafluoroethylene (PTFE) can be used. PTFE is resistant to high temperatures and can withstand high-temperature steam sterilization at 130 °C, making it suitable for sterile environments; it is also resistant to biological contamination, has a smooth surface, and is not easily adsorbed with proteins or organic substances; and it is corrosion-resistant and can resist the corrosion of blood, body fluids, and strong acid and strong base media.

[0125] The encapsulation method of the pH detection unit 103 includes: First, deposit the pH electrode protective layer 1034 on the two electrodes of the pH sensor chip 1031 by chemical vapor deposition; then, press-bond the enameled wire 1032 of the pH chip to the two pads 10311 of the pH sensor chip 1031; further, position the pH sensor chip 1031 in the window area of the pH chip metal protection frame 1035; further, coat the pH chip coating 1033; finally, perform thermal curing and cure at 80 °C for 6 h. After encapsulation, pH calibration needs to be carried out in a standard buffer solution with pH = 6.86.

[0126] Reference Figure 13 , Figure 13 For Figure 1 shown is a top view of the oxygen partial pressure detection unit in the implantable sensor encapsulation structure. The oxygen partial pressure detection unit 104 serves as Figure 1 the fourth detection area in the shown scheme, including: an oxygen sensor chip 1041, an oxygen chip enameled wire 1042, an oxygen chip coating 1043, an oxygen electrode protective layer 1044, and an oxygen chip metal protection frame 1045.

[0127] Among them, the oxygen sensor chip 1041 is the core device for detecting intracranial oxygen, and it includes: pads 10411, an oxygen reference electrode 10412, an oxygen counter electrode 10413, an oxygen working electrode 10414, and an oxygen electrode lead 10415. The oxygen reference electrode 10412 can be an Ag / AgCl electrode, the oxygen counter electrode 10413 can be a glassy carbon (GC) electrode, and the oxygen working electrode 10414 can be a platinum electrode. Oxygen undergoes a reduction reaction on the oxygen working electrode, and the current signal of this reaction is proportional to the oxygen concentration and can be used for quantitative analysis of oxygen concentration. An oxidation reaction occurs on the oxygen counter electrode to supplement electrons and ensure the closure of the current loop, enabling the oxygen reduction reaction on the oxygen working electrode to continue. The oxygen reference electrode is used to provide a stable potential reference point to ensure the constant potential of the oxygen working electrode.

[0128] The cerebral oxygen electrode lead 10415 connects three electrodes to three pads 10411 respectively; the enameled wire 1042 of the cerebral oxygen chip is connected to the pad 10411 by thermocompression bonding to transmit the output of the cerebral oxygen sensor chip to the circuit board at the tail of the probe for signal processing. The cerebral oxygen chip coating 1043 is used to protect the enameled wire 1042 of the cerebral oxygen chip, the pad 10411 and the cerebral oxygen electrode lead 10415, and an epoxy resin material with good biocompatibility and insulation can be used. The cerebral oxygen electrode protection layer 1044 is used to ensure the stability of the electrode in the intracranial environment. For short-term detection, a hydrogel material with excellent oxygen permeability and slight immune rejection reaction can be used, and for long-term detection, a silicone rubber material with excellent oxygen permeability, corrosion resistance and anti-aging can be used.

[0129] The encapsulation method of the oxygen partial pressure detection unit 104 includes: First, deposit the cerebral oxygen electrode protection layer 1044 on the three electrodes of the cerebral oxygen sensor chip 1041 by chemical vapor deposition; then, press-weld the enameled wire 1042 of the cerebral oxygen chip to the three pads 10411 of the cerebral oxygen sensor chip 1041; further, position the cerebral oxygen sensor chip 1041 in the window area of the cerebral oxygen chip metal protection frame 1045; further, coat the cerebral oxygen chip coating 1043; finally, perform thermal curing and cure at 80 °C for 6 h. After encapsulation, oxygen content calibration needs to be carried out under the three-gas conditions of 0% O 2 、5% O 2 、10% O 2 .

[0130] Among them, Figure 1 in, each chip metal protection frame is the protection frame 109 in the corresponding sensor unit 107, and each chip enameled wire is the signal wire 112 connected to the sensor chip in the corresponding sensor unit 107.

[0131] Based on the implantable sensor encapsulation structure 100 provided in the above embodiment, another embodiment of the present application further provides a biometric signal acquisition system, and the biometric signal acquisition system can be as Figure 14 shown.

[0132] Refer to Figure 14 , Figure 14 which is a schematic structural diagram of a biometric signal acquisition system provided by an embodiment of the present application, including: the implantable sensor encapsulation structure 100 provided in any of the above embodiments; an external monitor 115, and the external monitor 115 is communicatively connected to the implantable sensor encapsulation structure 100. Figure 14 The dotted line in

[0133] Optionally, in the implantable sensor packaging structure 100, a sensor chip interface circuit and a wireless transmission circuit are provided in the base 106. The signals collected by the sensor chip can be transmitted to the outside of the body through the wireless transmission circuit, and the display and analysis of the collected biometric signals can be realized outside the body through the external monitor 115.

[0134] The biometric signal acquisition system includes the implantable sensor packaging structure 100. Therefore, the biometric signal acquisition system provided by the embodiments of the present application has the same or similar technical effects as the implantable sensor packaging structure 100 provided by the above embodiments, and the embodiments of the present application will not be elaborated herein.

[0135] In the description of the present application, each embodiment is described in a progressive, or parallel, or a combination of progressive and parallel manners. The key point of each embodiment is to illustrate the differences from other embodiments. The same or similar parts among the embodiments can be referred to each other. The embodiments provided by the embodiments of the present application can be combined with each other without conflict.

[0136] It should be noted that in the description of the present application, it should be understood that the descriptions of the drawings and embodiments are illustrative rather than restrictive. The same reference numerals throughout the embodiments of the specification identify the same structures. Additionally, for the sake of understanding and easy description, the drawings may exaggerate the thickness of some layers, films, panels, regions, etc. At the same time, it can be understood that when an element such as a layer, film, region, or substrate is referred to as being "on" another element, the element can be directly on the other element or there may be intermediate elements. Additionally, "on..." means positioning the element on or below another element, but essentially does not mean positioning on the upper side of another element according to the direction of gravity.

[0137] The orientation or positional relationship indicated by terms such as "upper", "lower", "top", "bottom", "inner", "outer", etc. is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as a limitation of the present application. When a component is considered to be "connected" to another component, it can be directly connected to the other component or there may be intermediate components present.

[0138] It should also be noted that, in this document, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the term "comprising", "including" or any other variant thereof is intended to cover non-exclusive inclusion, so that an article or device comprising a series of elements not only includes those elements, but also includes other elements not expressly listed, or also includes elements inherent to such article or device. Without further limitation, an element defined by the statement "comprising an..." does not exclude the presence of additional identical elements in the article or device comprising the above elements.

[0139] The above description of the disclosed embodiments enables those skilled in the art to implement or use the present application. Various modifications to these embodiments will be obvious to those skilled in the art, and the general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present application. Therefore, the present application will not be limited to the embodiments shown herein, but rather to the broadest scope consistent with the principles and novel features disclosed herein.

Claims

1. An implantable sensor packaging structure, characterized in that: include: Pedestal; a catheter assembly fixed on a side surface of the base; A plurality of sensor units are arranged in the catheter assembly, and each of the sensor units is used to detect different types of biological characteristic signals; wherein a detection window is arranged on the side wall of the catheter assembly, and the detection window is used to expose the sensor unit.

2. The implantable sensor packaging structure according to claim 1, characterized in that: The catheter assembly comprises: At least one section of tubular protection frame, wherein the wall of the protection frame has an opening for forming the detection window; A support member is located in the protection frame, and is used to support the pipe wall of the protection frame, and is also used to carry the sensor unit.

3. The implantable sensor packaging structure according to claim 2, characterized in that: The support member is a flat plate structure, and the plane where the flat plate structure is located is parallel to an inner diameter direction of the protection frame; Wherein, one sensor unit is respectively arranged on two opposite surfaces of the flat plate structure.

4. The implantable sensor packaging structure according to claim 2, characterized in that: The support member is a flat plate structure, comprising at least two sections of the protection frame, and the planes where the flat plate structures in two adjacent protection frames are located intersect.

5. The implantable sensor packaging structure according to claim 2, characterized in that: In the same support member, the support member includes a plurality of flat plate structures; In the same support member, the planes where each of the flat plate structures are located are parallel to an inner diameter direction of the protection frame, and each of the flat plate structures crosses within the protection frame to form a plurality of sector-shaped partitions, and the sensor unit is located within the sector-shaped partitions; each of the sensor units is located within different sector-shaped partitions.

6. The implantable sensor packaging structure according to claim 5, characterized in that: In the same support member, the central angles of the multiple sector-shaped partitions are the same, each sector-shaped partition is correspondingly provided with a sensor unit, and the catheter assembly is respectively provided with a detection window corresponding to each sector-shaped partition; Or, in the same support member, the plurality of sector-shaped partitions include a plurality of first sector-shaped partitions and second sector-shaped partitions arranged alternately, the first sector-shaped partitions are used to set the sensor unit, and the second sector-shaped partitions are used to set the signal line connected to the sensor unit.

7. The implantable sensor packaging structure according to claim 2, characterized in that: The catheter assembly comprises a plurality of protection frames corresponding to the sensor units one by one, and each of the protection frames is provided with a corresponding sensor unit; In the length direction of the catheter assembly, the protection frames are arranged in sequence.

8. The implantable sensor packaging structure according to any one of claims 2 to 7, characterized in that: Also included is an outer tube covering the protection frame, the outer tube having an opening exposing the detection window; Or, along the length direction of the catheter assembly, the catheter assembly includes a plurality of sections of the protection frames arranged in sequence, and a section of insulating tube is provided between adjacent protection frames, the insulating tube is used to pass the signal line connected to the sensor unit, and is used to fill the colloid for bonding and fixing the protection frame; Or, the tube wall of the protection frame has at least one glue injection hole, and the glue injection hole is used to inject colloid; Alternatively, the protection frame is one of a titanium frame, a stainless steel frame, a titanium alloy frame and a ceramic frame.

9. The implantable sensor packaging structure according to any one of claims 1 to 7, characterized in that: The plurality of sensor units include: at least two of a pressure detection unit, a temperature detection unit, a pH detection unit, and an oxygen partial pressure detection unit; Or, one of the plurality of sensor units is a pressure detection unit, the pressure detection unit comprises a pressure sensor chip; the pressure detection area of ​​the pressure sensor chip is covered with a pressure-sensitive protective film; the surface of the pressure-sensitive protective film is covered with a pressure chip coating; Or, the surface of the sensor unit is covered with a protective layer; Or, one of the plurality of sensor units is a pH detection unit, the pH detection unit comprising a pH sensor chip and a pH working electrode connected to the pH sensor chip, the pH working electrode comprising a glass membrane sensitive to hydrogen ions; Alternatively, one of the plurality of sensor units is an oxygen partial pressure detection unit, and a surface of the oxygen partial pressure detection unit is covered with a hydrogel protective layer or a silicone rubber protective layer.

10. A biometric signal acquisition system, characterized in that: include: The implantable sensor packaging structure according to any one of claims 1 to 9; An in vitro monitor is communicatively connected to the implantable sensor packaging structure.

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