Tendon relaxing and bone strengthening health care cream and preparation method thereof

Abstract

The invention discloses a tendon-relaxing and bone-strengthening health-care cream and a preparation method thereof. The tendon-relaxing and bone-strengthening health-care cream is composed of wintergreen oil, a Chinese starjasmine stem extract, rhodiola rosea polysaccharide and other active components and an emulsion matrix. Through the supercritical extraction-graded extraction-low-temperature emulsification technology, efficient delivery of anti-inflammatory and analgesic components is achieved, the double effects of rapid relieving and tissue repairing on joint swelling and pain are achieved, and the transdermal efficiency is improved by 170% or above compared with that of a traditional preparation.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine external preparations, and specifically to a compound health cream combining traditional Chinese medicine extracts and modern preparation techniques, which is applicable to relieving sub-healthy symptoms such as joint pain and swelling, and muscle stiffness. Background Art

[0002] Patients with neck, shoulder, waist and leg pain mostly rely on non-steroidal anti-inflammatory drugs or ordinary plasters, which have problems such as liver and kidney toxicity, skin allergies, etc. Traditional Chinese medicine plasters generally have technical bottlenecks such as low transdermal absorption rate (for example, the transdermal rate of ordinary black plasters is only 3-5%), and thermosensitive loss of active ingredients. The present invention constructs a multi-channel penetration system through innovative step-by-step extraction and low-temperature emulsification processes to achieve targeted delivery to deep tissues. Summary of the Invention

[0003] Technical Problem

[0004] To provide an external preparation with both rapid analgesic and bone and muscle repair functions, and break through the technical barriers of low transdermal efficiency and degradation of active ingredients in traditional preparations.

[0005] Technical Solution

[0006] 1. Composition of raw materials (by mass percentage):

[0007] Volatile oil extract (8-15%):

[0008] Wintergreen oil 2-4%, turpentine oil 2-4%, Erycibe obtusata oil 1-3%, cinnamon oil 1-3%, dried ginger oil 1-3%

[0009] Alcohol extract (10-20%):

[0010] Trachelospermum jasminoides extract 3-6%, Notopterygium incisum extract 2-5%, Angelica pubescens extract 2-5%, Flemingia philippinensis extract 2-4%

[0011] Water extract (5-12%):

[0012] Rhodiola rosea polysaccharide 2-4%, water-soluble components of Ligusticum chuanxiong 1-3%, magnolol substances 1-3%, flavone of Cyperus rotundus 1-2%

[0013] Matrix excipients (55-75%):

[0014] Glycerol monostearate and distearate 10-15%, costus root oil 1-2%, potassium sorbate 0.1-0.3%, purified water as the balance

[0015] 2. Preparation method:

[0016] a. Extraction of volatile oil: Extract Erycibe obtusata, cinnamon, and dried ginger by supercritical CO2 extraction (pressure 25 MPa, temperature 45°C)

[0017] b. Preparation of ethanol extract: Trachelospermum jasminoides, Notopterygium incisum, Angelica pubescens, Flemingia philippinensis were refluxed and extracted with 70% ethanol three times, and the extracts were combined and concentrated to a relative density of 1.15 - 1.20

[0018] c. Preparation of water extract: Rhodiola rosea, Ligusticum chuanxiong, Magnolia officinalis, Cyperus rotundus were decocted twice, and the extract was purified by macroporous resin

[0019] d. Construction of emulsion system:

[0020] Oil phase: Glyceryl monostearate and diglyceride were mixed with volatile oil and heated to 65°C

[0021] Water phase: The water extract and potassium sorbate were dissolved in purified water and heated to 65°C

[0022] The water phase was added to the oil phase under high-speed homogenization (10,000 rpm), and the ethanol extract was added when the temperature was lowered to 45°C

[0023] e. Filling and sterilization: After filling and maintaining at 50°C, it was sterilized by 60Co irradiation

[0024] Beneficial effects

[0025] 1. Triple composite penetration: Wintergreen oil (methyl salicylate) opens the stratum corneum barrier, the volatile oil extracted by supercritical fluid with a particle size ≤ 200 nm penetrates deep fascia, and rhodiola polysaccharide forms a hydration channel

[0026] 2. Synergistic mechanism: Tracheloside inhibits the IL-1β inflammatory factor, the volatile oil of Notopterygium incisum blocks the TRPV1 pain receptor, and the coumarin of Angelica pubescens promotes the proliferation of chondrocytes

[0027] 3. Clinical data: 200 patients with lumbar disc herniation were topically applied three times a day. After 28 days, the VAS pain score decreased by 72.4%, and the improvement rate of joint range of motion was 83.6% Description of the drawings

[0028] Figure 1 It is a process flow chart of a muscle and bone strengthening health cream Detailed implementation manners

[0029] Example 1

[0030] Raw material ratio (total mass 1000 g):

[0031] Volatile oil extract: 30 g of wintergreen oil, 30 g of turpentine oil, 20 g of Erycibe obtusata oil, 20 g of cinnamon oil, 20 g of dried ginger oil

[0032] Ethanol extract: 50 g of Trachelospermum jasminoides extract, 40 g of Notopterygium incisum extract, 40 g of Angelica pubescens extract, 30 g of Flemingia philippinensis extract

[0033] Aqueous extract: 30 g of rhodiola polysaccharide, 20 g of water-soluble components of ligusticum chuanxiong, 15 g of magnolol substances, 10 g of cyperus rotundus flavonoids

[0034] Matrix excipients: 120 g of glyceryl monostearate and distearate, 15 g of costus root oil, 2 g of potassium sorbate, 554 g of purified water

[0035] Preparation process:

[0036] 1. Supercritical CO2 extraction of erycibe obtusata, cinnamon, and dried ginger (28 MPa, 42 °C) to obtain a mixed volatile oil

[0037] 2. The alcohol extract is concentrated by rotary evaporation to a density of 1.18 g / cm 3

[0038] 3. The aqueous extract is purified by AB-8 macroporous resin (ethanol gradient elution)

[0039] 4. The oil phase and the water phase are homogenized and emulsified at 65 °C, and the alcohol extract is added after cooling to 45 °C

[0040] 5. After filling, the irradiation sterilization effect is verified with a dose of 8 kGy

[0041] In vitro percutaneous penetration experiment on porcine skin: The cumulative penetration amount reaches 1.82 mg / cm in 24 hours 2 (2.7 times that of traditional ointment) - Micro-CT shows that after 4 weeks of use in a rabbit knee arthritis model, the cartilage thickness increases by 23.8%.

Claims

1. A muscle-relaxing and bone-strengthening health cream, characterized in that It is composed of the following components in percentage by mass: Volatile oil extract 8-15%: wintergreen oil 2-4%, turpentine oil 2-4%, truncatum oil 1-3%, cinnamon oil 1-3%, dried ginger oil 1-3% Alcohol extract 10-20%: Trachelospermum officinale extract 3-6%, Notopterygium wilfordii extract 2-5%, Angelica dahurica extract 2-5%, Eleutherodactylum chinensis extract 2-4% Water extract 5-12%: Rhodiola rosea polysaccharide 2-4%, water-soluble components of Chuanxiong 1-3%, magnolia bark phenols 1-3%, flavonoids of Cyperus rotundus 1-2% Matrix excipients 55-75%: mono- and distearic acid glyceryl 10-15%, costus root oil 1-2%, potassium sorbate 0.1-0.3%, and the balance purified water.

2. The health cream according to claim 1, characterized in that The volatile oil extract is prepared by supercritical CO2 extraction process, with an extraction pressure of 20-30MPa and a temperature of 40-50°C.

3. The health cream according to claim 1, characterized in that The preferred ratio of active components is: 3% of wintergreen oil, 3% of turpentine oil, 2% of truncatum oil, 2% of cinnamon oil, 2% of dried ginger oil, 5% of Trachelospermum jasminoides extract, 4% of Notopterygium wilfordii extract, 4% of Angelica dahurica extract, 3% of Eleutherodactyla scabra extract, 3% of Rhodiola rosea polysaccharide, 2% of water-soluble components of Ligusticum chuanxiong, 2% of magnolia bark phenols, and 1.5% of Cyperus rotundus flavonoids.

4. A method for preparing the muscle-relaxing and bone-strengthening health cream according to any one of claims 1 to 3, characterized in that The following steps are involved: a. Prepare volatile oil extract, alcohol extract and water extract separately b. Constructing the oil phase and water phase emulsification system c. Add the alcohol extract to the emulsified base at 45-50°C d. Use irradiation sterilization after filling.

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