Packaging method of hydrogen-containing medicine

Abstract

The invention relates to the technical field of medicine, in particular to a hydrogen-containing medicine packaging method which comprises a negative plate with medicine outlet holes and bubble caps, and one or more hydrogen-containing medicines are placed in each bubble cap. The bottom sheet and the bubble cap are tightly bonded, the bottom sheet and the bubble cap are made of aluminum foil or plastic sandwiched with an aluminum foil layer or high-density polypropylene, the package adopts the aluminum foil with a low hydrogen diffusion coefficient or the plastic sandwiched with the aluminum foil layer or the high-density polypropylene to package the hydrogen-containing medicine, and the bubble cap is filled with hydrogen to prevent the hydrogen in the hydrogen-containing medicine from diffusing and escaping; and the structure is simple, existing medicine packaging machinery can be used, and an effective packaging method is provided for popularization of the gas-containing medicine.

Description

Technical Field

[0001] The present invention relates to the field of pharmaceutical technology, and specifically to a packaging method for hydrogen-containing drugs. Background Art

[0002] Hydrogen biomedicine has also been highly recognized in the global medical field. At present, the main ways for the human body to absorb hydrogen molecules mainly include two ways: inhaling hydrogen and drinking hydrogen water. However, research shows that the metabolism of hydrogen molecules and their therapeutic effects on the human body are likely to be achieved after being absorbed through the intestine and entering the blood and liver; inhaling hydrogen is difficult to achieve the above hydrogen molecule absorption process, and drinking hydrogen water first enters the stomach, and hydrogen molecules are not easily reached the intestine. Patent 202110015201.9 provides a hydrogen-containing capsule and its preparation method. This patent uses a capsule shell to wrap hydrogen as a whole, claiming advantages such as controllable hydrogen content, high stability, convenient use according to dosage, and suitability for large-scale production. This patent provides a new idea for the human body to absorb hydrogen and can further promote the development of hydrogen medicine. However, due to the small size and large diffusion coefficient of hydrogen molecules, ordinary capsule shell materials cannot effectively "lock" hydrogen, and the hydrogen in the capsule can diffuse from the capsule into the air through free diffusion in a very short time, resulting in the failure of the hydrogen capsule.

[0003] In view of this, the present invention provides a packaging method for hydrogen-containing drugs. This packaging uses aluminum foil with a low hydrogen diffusion coefficient or plastic or high-density polypropylene with an aluminum foil layer to package hydrogen-containing drugs, and fills hydrogen in the blister to prevent the hydrogen in the hydrogen-containing drugs from diffusing and escaping, affecting the drug efficacy. Moreover, the structure is simple and existing pharmaceutical packaging machinery can be used, providing an effective packaging method for the promotion of gas-containing drugs. Summary of the Invention

[0004] The purpose of the present invention is to provide a packaging method for hydrogen-containing drugs to solve the problems raised in the above background art.

[0005] To achieve the above purpose, the present invention provides the following technical solutions:

[0006] A packaging method for hydrogen-containing drugs, characterized in that it includes a bottom sheet and a bottom seal with a drug outlet hole and blisters, and one or more hydrogen-containing drugs are placed in each blister; the bottom sheet and the blisters are integrally formed or tightly bonded, and the bottom seal is tightly bonded to the bottom sheet; the materials of the bottom sheet, blisters and bottom seal are aluminum foil or plastic with an aluminum foil layer or high-density polypropylene;

[0007] Among them, the hydrogen-containing drug refers to a capsule with hydrogen wrapped inside or a tablet or pill adsorbed with hydrogen;

[0008] Among them, each blister is filled with a gas with a hydrogen volume fraction > 50%, and the internal pressure of the blister ≥ 0.1 Mpa.

[0009] Furthermore, the thickness of the aluminum foil > 20μm, and the hydrogen permeability coefficients of the materials of the negative film, blister and bottom seal < 1×10 -12

[0010] mol / s / m / Pa 1 / 2 。

[0011] Compared with the prior art, the beneficial effects of the present invention are as follows: This packaging uses aluminum foil with a low hydrogen diffusion coefficient, or plastic or high-density polypropylene sandwiching an aluminum foil layer to package hydrogen-containing drugs, and fills hydrogen in the blister to prevent the hydrogen in the hydrogen-containing drugs from diffusing and escaping, which affects the drug efficacy. Moreover, the structure is simple, and existing pharmaceutical packaging machinery can be used, providing an effective packaging method for the popularization of gas-containing drugs. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] Figure 1 is a flowchart of the present invention.

[0013] Figure 2 is an overall schematic diagram of the present invention.

[0014] In the figure: 1 is a conveyor belt, 2 is a capsule dispenser, 3 is an unsealed package, 4 is a package filled with hydrogen-containing capsules, 5 is a bottom-sealing machine, 6 is a hydrogen inlet, 7 is a damper, 8 is a hydrogen outlet, 9 is a bottom-sealed package, 101 is a negative film, 102 is a blister, 103 is a hydrogen-containing capsule, 104 is a bottom seal. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0015] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0016] In the description of the present invention, it should be understood that the orientation or positional relationship indicated by the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of the present invention.

[0017] In the description of this patent, it should be noted that unless otherwise clearly specified and defined, the terms "installation", "connection", "linkage", and "setting" should be understood in a broad sense. For example, it can be fixedly connected and set, or detachably connected and set, or integrally connected and set. For those of ordinary skill in the art, the specific meanings of the above terms in this patent can be understood according to specific circumstances. In the description of the present invention, "a plurality of" means two or more, unless otherwise clearly and specifically defined.

[0018] Please refer to Figure 1 - Figure 2 As shown in the figure, an embodiment of a packaging method for a hydrogen-containing drug provided by the present invention:

[0019] On the 101 negative film made of high-density polypropylene material with a 50-μm aluminum foil sandwich, there are 16 blisters 102 made of high-density polypropylene material with a 50-μm aluminum foil sandwich. The unsealed package 3 passes through the capsule dispenser 2 via the conveyor belt 1, and 1 hydrogen-containing capsule 103 is placed in each blister; the unsealed package 3 containing the hydrogen-containing capsule 103 then enters the sealer 5 via the conveyor belt 1. Air doors 7 are provided at the inlet and outlet of the sealer 5 to isolate external air. The sealer 5 is also provided with a hydrogen inlet 6 and a hydrogen outlet 8. Hydrogen enters the sealer 5 through the hydrogen inlet 6 and then exits the sealer 5 through the hydrogen outlet 8; the unsealed package 3 entering the sealer 5 is sealed by the seal 104, so that the blister 102 is filled with hydrogen with a purity of 99.9% and a pressure of 0.15 MPa. Finally, it is removed from the sealer 5 via the conveyor belt 1 to complete the entire packaging process.

[0020] Compared with the prior art, the beneficial effects of the present invention are as follows: This packaging uses aluminum foil with a low hydrogen diffusion coefficient, or plastic or high-density polypropylene sandwiching an aluminum foil layer to package hydrogen-containing drugs, and fills hydrogen in the blisters to prevent the hydrogen in the hydrogen-containing drugs from diffusing and escaping, which affects the drug efficacy. Moreover, the structure is simple, and existing pharmaceutical packaging machinery can be used, providing an effective packaging method for the popularization of gas-containing drugs.

[0021] The above shows and describes the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited by the above embodiments. The above embodiments and the descriptions in the specification are only preferred examples of the present invention and do not limit the present invention. Without departing from the spirit and scope of the present invention, the present invention will have various changes and improvements, and these changes and improvements all fall within the scope of the present invention claimed. The scope of protection claimed by the present invention is defined by the appended claims and their equivalents.

Claims

1. A packaging method for a hydrogen-containing drug, characterized in that, It includes a bottom film and a bottom cover with medicine outlet holes and blisters, and one or more hydrogen-containing drugs are placed in each blister; the bottom film and the blisters are integrally formed or tightly bonded, and the bottom cover is tightly bonded to the bottom film; the materials of the bottom film, the blisters and the bottom cover are aluminum foil or plastics with an aluminum foil layer or high-density polypropylene; Among them, the hydrogen-containing drug refers to a capsule containing hydrogen inside or a tablet or pill adsorbed with hydrogen; Among them, each blister is filled with a gas with a hydrogen volume fraction > 50%, and the internal pressure of the blister ≥ 0.1 Mpa.

2. The packaging method for a hydrogen-containing drug according to claim 1, characterized in that, The thickness of the aluminum foil > 20 μm.

3. The packaging method for a hydrogen-containing drug according to claim 1, characterized in that, The hydrogen permeability coefficient of the negative film, blister and back cover material < 1×10 -12 mol / s / m / Pa 1 / 2 .

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