Combination of one or more alkylaminothiazoles and cylinylene diethylhexyl malone and cosmetic formulations containing

Abstract

The present invention relates to a combination of one or more alkylamidothiazoles and carylidenemalonic acid diethylhexyl esters and cosmetic formulations containing such a combination. In particular, the present invention relates to an active ingredient combination of a) one or more alkylamidothiazoles and b) a diethyl hexyl syringyl malonate in c) a cosmetic excipient.

Description

Technical Field

[0001] The present invention belongs to the field of beauty and specifically relates to a combination of one or more alkylamidothiazoles and diethylhexyl syringylmalonate, as well as a beauty preparation containing such a combination. Background Art

[0002] Generally speaking, beauty products not only make people look beautiful and charming, but their effects also make a decisive contribution to enhancing people's self-esteem and well-being. Therefore, a variety of beauty products are used for the daily cleansing and care of human skin. For example, a beauty preparation for human skin care is known from DE 102011083259 A1, which contains alkylamidothiazole.

[0003] The alkylamidothiazole used is for combating and preventing unwanted skin pigmentation in beauty preparations. In this way, the skin color of the user can be significantly improved.

[0004] It is also known from DE 102013226711 A1 that alkylamidothiazole can be used in beauty or dermatological preparations for the prevention and treatment of sensitive skin, itching, dry skin and inflammatory symptoms of human skin. The document discloses various beauty O / W emulsions applied to human skin.

[0005] In addition, DE 102013204110 A1 discloses a large number of beauty preparations for human skin care containing alkylamidothiazole.

[0006] By the combined use of alkylamidothiazole with one or more cyclodextrins, particularly effective whitening of human skin can be achieved.

[0007] However, the fact that those skilled in the art know a large number of beauty preparations containing alkylamidothiazole cannot obscure the fact that a large number of problems may arise when formulating beauty or dermatological preparations.

[0008] For example, one drawback is the fact that the color of newly produced beauty or dermatological preparations changes during storage. This situation is more serious when the preparation is exposed to light.

[0009] This situation poses considerable difficulties to the manufacturers of beauty preparations because it is necessary to study the color stability of beauty preparations.

[0010] This usually requires a large number of methods, which greatly increases the development cost of beauty products.

[0011] Therefore, it is desirable to provide systems and methods that can effectively prevent or minimize the degradation process in beauty or dermatological preparations, so that the development cost can be minimized. The problem of the degradation process in beauty or dermatological preparations is also relevant to consumers.

[0012] Products are usually selected based on their optical appearance or their outer surface. However, if the white appearance of a product deteriorates during storage, consumers are usually annoyed because it no longer meets the decisive purchase criteria.

[0013] In principle, the color stability of cosmetic or dermatological preparations can be evaluated by specially trained personnel who compare freshly prepared preparations (within 24 hours after preparation) with the color after the corresponding storage time. However, color changes in products are always difficult to judge. Therefore, it is advantageous to use a special instrument called Digi-Eye for color changes.

[0014] Therefore, an object of the present invention is to provide a method for preventing or minimizing the degradation process in cosmetic products in a particularly effective manner, thereby ensuring color stability. Summary of the Invention

[0015] This object is achieved by an active ingredient combination of a) one or more alkylamidothiazoles and b) diethylhexyl syringylmalonate in c) a cosmetic excipient.

[0016] Surprisingly, compared with single substances, the combination of diethylhexyl syringylmalonate and 3-O-ethylascorbic acid prevents or reduces the degradation of alkylamidothiazoles caused by oxidation processes and / or heat and / or UV light in a synergistic manner.

[0017] Another embodiment of the present invention is a cosmetic preparation containing such a combination.

[0018] Another embodiment of the present invention is a method of using b) diethylhexyl syringylmalonate in c) a cosmetic excipient for preventing or reducing the degradation of alkylamidothiazoles caused by oxidation processes and / or heat and / or UV light in a cosmetic preparation containing one or more alkylamidothiazoles.

[0019] An advantageous embodiment of the present invention is also a cosmetic or dermatological preparation containing such an active ingredient combination and its use for whitening human skin. Detailed Description of the Invention

[0020] Advantageously, the preparation according to the present invention comprises a formulation in which, in order to provide a cosmetic preparation, the total amount of the one or more alkylamidothiazoles is, for example, from 0.00001% by weight to 10% by weight, preferably from 0.001% by weight to 5% by weight, in particular from 0.005% by weight to 3% by weight, based on the total weight of the preparation.

[0021] In an advantageous case, the preparation according to the invention comprises a formulation, wherein, for providing a cosmetic preparation, the total amount of diethylhexyl syringylmalonate is, based on the total weight of the preparation, for example from 0.00001% by weight to 10% by weight, preferably from 0.001% by weight to 5% by weight, in particular from 0.005% by weight to 3% by weight.

[0022] In an advantageous case, the preparation according to the invention comprises a formulation, which may additionally contain an active amount of α-tocopherol. Preferably, for providing a cosmetic preparation, the total amount of α-tocopherol is, based on the total weight of the preparation, for example from 0.00001% by weight to 10% by weight, preferably from 0.001% by weight to 5% by weight, in particular from 0.005% by weight to 3% by weight.

[0023] In an advantageous case, the preparation according to the invention comprises a formulation, which may additionally contain an active amount of β-tocopherol. Preferably, for providing a cosmetic preparation, the total amount of β-tocopherol is, based on the total weight of the preparation, for example from 0.00001% by weight to 10% by weight, preferably from 0.001% by weight to 5% by weight, in particular from 0.005% by weight to 3% by weight.

[0024] In an advantageous case, the preparation according to the invention comprises a formulation, which may additionally contain an active amount of dimethylmethoxy chromanol. Preferably, for providing a cosmetic preparation, the total amount of dimethylmethoxy chromanol is, based on the total weight of the preparation, for example from 0.00001% by weight to 10% by weight, preferably from 0.001% by weight to 5% by weight, in particular from 0.005% by weight to 3% by weight.

[0025] Dimethylmethoxy chromanol is a well-known antioxidant. It is characterized by the following chemical structure:

[0026]

[0027] In an advantageous case, the preparation according to the invention comprises a formulation, which may additionally contain an active amount of niacinamide. Preferably, for providing a cosmetic preparation, the total amount of niacinamide is, based on the total weight of the preparation, for example from 0.00001% by weight to 10% by weight, preferably from 0.001% by weight to 5% by weight, in particular from 0.005% by weight to 3% by weight.

[0028] Niacinamide is a form of vitamin B3, which is present in food and is used as a dietary supplement and a drug. [2][3][4] As a supplement, it is taken orally for the prevention and treatment of pellagra (niacin deficiency). Niacinamide is characterized by the following structural formula:

[0029]

[0030] In another aspect, based on the total weight of the formulation, the formulation may comprise less than about 1.5 wt% of one or more hydrocolloids, such as not more than about 1.0 wt% of one or more hydrocolloids and / or at least about 0.1 wt% of one or more hydrocolloids.

[0031] In another aspect of the formulation, the one or more hydrocolloids may comprise one or more of the following:

[0032] a) Organic total synthesis compounds of polyacrylic acid,

[0033] b) Copolymers and crosslinked polymers of polyacrylic acid derivatives

[0034] c) Ammonium salts of dimethyl tauramide / vinylformamide copolymers

[0035] d) Copolymers / crosslinked polymers containing acryloyldimethyltaurate

[0036] e) Hydrophilic gums and their hydrophilic derivatives

[0037] f) Cellulose, cellulose derivatives, and microcrystalline cellulose.

[0038] In another aspect, the one or more hydrocolloids may comprise one or more polyacrylates selected from Carbopol types 980, 981, 1382, 2984, and 5984 and Carbopol ULTREZ.

[0039] In another aspect, the one or more hydrocolloids may comprise one or more of polymethacrylate, acrylate copolymer, alkyl acrylate copolymer, polyacrylamide, alkyl acrylate crosslinked polymer, acrylonitrile copolymer, and polyacryloyldimethyltauramide.

[0040] In another aspect, the one or more hydrocolloids may comprise one or more of agar, alginic acid, carrageenan, gelatin, gum arabic, pectin, and tragacanth and / or one or more of guar gum, locust bean gum, xanthan gum, polyvinyl alcohol, polyvinylpyrrolidone, propylene glycol alginate, and starch.

[0041] In another aspect, the one or more hydrocolloids may comprise alkyl-modified cellulose derivatives and / or alkyl hydroxycelluloses, such as at least one of methylcellulose, hydroxypropylmethylcellulose, and hydroxyethylcellulose.

[0042] In another aspect, the formulation may comprise at least about 0.1 wt% and / or not more than about 1.0 wt% of the one or more hydrocolloids.

[0043] In another aspect, the one or more hydrocolloids may comprise Carbopol ULTREZ and / or at least one of agar, alginic acid, carrageenan, gelatin, gum arabic, pectin, and gum tragacanth and / or at least one of guar gum, locust bean flour, xanthan gum, gellan gum, polyvinyl alcohol, polyvinylpyrrolidone, propylene glycol alginate, and starch and / or at least one of methylcellulose, hydroxypropylmethylcellulose, and hydroxyethylcellulose.

[0044] In the context of the present invention, advantageous alkylamidothiazoles are substances of the following general formula:

[0045]

[0046] wherein R1, R2, X, and Y can be different, partially the same, or completely the same, and can independently of one another denote:

[0047] R1 = —C1-C24-alkyl (linear and branched), —C1-C24-alkenyl (linear and branched), —C1-C8-cycloalkyl, —C1-C8-cycloalkyl-alkyl-hydroxy, —C1-C24-alkyl-hydroxy (linear and branched), —C1-C24-alkylamine (linear and branched), —C1-C24-alkylaryl (linear and branched), —C1-C24-alkylaryl-alkyl-hydroxy (linear and branched), —C1-C24-alkylheteroaryl (linear and branched), —C1-C24-alkyl-O—C1-C24-alkyl (linear and branched), —C1-C24-alkyl-morpholinyl, —C1-C24-alkyl-piperidinyl, —C1-C24-alkyl-piperazinyl, —C1-C24-alkyl-piperazinyl-N-alkyl,

[0048] R2 = H, —C1-C24-alkyl (linear and branched), —C1-C24-alkenyl (linear and branched), —C1-C8-cycloalkyl, —C1-C24-hydroxyalkyl (linear and branched), —C1-C24-alkylaryl (linear and branched), —C1-C24-alkylheteroaryl (linear and branched),

[0049] X = —H, —C1-C24-alkyl (linear and branched), —C1-C24-alkenyl (linear and branched), —C1-C8-cycloalkyl, —C1-C24-aryl (optionally mono- or polysubstituted by —OH, —F, —Cl, —Br, —I, —OMe, —NH2, —CN), —C1-C24-heteroaryl (optionally mono- or polysubstituted by —OH, —F, —Cl, —Br, —I, —OMe, —NH2, —CN), —C1-C24-alkylaryl (linear and branched), —C1-C24-alkylheteroaryl (linear and branched), -aryl (optionally mono- or polysubstituted by —OH, —F, —Cl, —Br, —I, —OMe, —NH2, —CN), -phenyl, -2,4-dihydroxyphenyl, -2,3-dihydroxyphenyl, -2,4-dimethoxyphenyl, -2,3-dimethoxyphenyl, Y = H, —C1-C24-alkyl (linear and branched), —C1-C24-alkenyl (linear and branched), —C1-C8-cycloalkyl, —C1-C24-aryl, —C1-C24-heteroaryl, —C1-C24-alkylaryl (linear and branched), —C1-C24-alkylheteroaryl (linear and branched), -aryl, -phenyl, -2,4-dihydroxyphenyl, -2,3-dihydroxyphenyl, -2,4-dimethoxyphenyl, -2,3-dimethoxyphenyl, —COO-alkyl, —COO-alkenyl, —COO-cycloalkyl, —COO-aryl, —COO-heteroaryl, and X, Y may also optionally = fused aromatic, where X and Y may form with each other an aromatic or aliphatic homocyclic or heterocyclic system having at most n ring-forming atoms, and where the number n may take values from 5 to 8, and the corresponding ring system may in turn be substituted by at most n-1 alkyl, hydroxy, carboxy, amino, nitrile functional groups, sulfur-containing substituents, ester groups and / or ether groups.

[0050] The thiazole may be in the form of the free base or a salt, such as fluoride, chloride, bromide, iodide, sulfate, carbonate, ascorbate, acetate or phosphate. In particular, it is in the form of a halogen salt, such as chloride and bromide.

[0051] Furthermore, an advantageous embodiment of the invention is a cosmetic or dermatological preparation having an effective content of one or more of the above alkylamidothiazoles.

[0052] The use of the above alkylamidothiazoles for the treatment and / or prevention of undesired skin pigmentation also falls within the scope of the invention.

[0053] Here, the treatment and / or prevention of undesired skin pigmentation can be carried out both in the cosmetic field and in the pharmaceutical field.

[0054] In this regard, the pharmaceutical (or dermatological) treatment is mainly understood to be for diseased skin conditions, while the cosmetic treatment and / or prevention of unwanted skin pigmentation is mainly related to healthy skin.

[0055] In a preferred case, X is selected from substituted phenyl, in which case the substituents (Z) can be selected from —H, —OH, —F, —Cl, —Br, —I, —OMe, —NH2, —CN, acetyl, and can be the same or different.

[0056]

[0057] In a particularly preferred case, X is selected from phenyl substituted by one or more hydroxyl groups, in which case the substituents (Z) can be selected from —H, —OH, —F, —Cl, —Br, —I, —OMe, —NH2, —CN, acetyl, preferably the following general structure, where Y, R1 and R2 can have the properties defined above.

[0058]

[0059] Particularly preferred compounds are those that meet the following conditions:

[0060] X =

[0061] Y = H

[0062] R1 = —C1-C24-alkyl (linear and branched), —C1-C24-alkenyl (linear and branched), —C1-C8-cycloalkyl, —C1-C8-cycloalkyl-alkyl-hydroxy, —C1-C24 alkyl-hydroxy (linear and branched), —C1-C24 alkylamine (linear and branched), —C1-C24-alkylaryl (linear and branched), —C1-C24-alkylaryl-alkyl-hydroxy (linear and branched), —C1-C24-alkylheteroaryl (linear and branched), —C1-C24-alkyl-O—C1-C24-alkyl (linear and branched), —C1-C24-alkyl-morpholinyl, —C1-C24 alkyl-piperidinyl, —C1-C24 alkyl-piperazinyl, —C1-C24 alkyl-piperazinyl-N-alkyl,

[0063] R2 = H, —C1-C24-alkyl (linear and branched),

[0064] Z = —H, —OH, —F, —Cl, —Br, —I, —OMe, —NH2, —CN, acetyl.

[0065] Particularly preferred are the compounds that meet the following conditions, where the pictures can be obtained from the "original literature":

[0066] X =

[0067] Y = H

[0068] R1 = —C1-C24 alkyl (linear and branched), —C1-C24 alkenyl (linear and branched), —C1-C8 cycloalkyl, —C1-C8 cycloalkyl-alkyl hydroxy, —C1-C24 alkyl hydroxy (linear and branched), —C1-C24 alkylamine (linear and branched), —C1-C24 alkylaryl (linear and branched), —C1-C24 alkyl-aryl-alkyl-hydroxy (linear and branched), —C1-C24 alkyl heteroaryl (linear and branched), —C1-C24 alkyl-O—C1-C24 alkyl (linear and branched), —C1-C24 alkyl morpholinyl, —C1-C24 alkyl piperidinyl, —C1-C24 alkyl piperazinyl, —C1-C24 alkyl piperazinyl-N-alkyl,

[0069] R2 = H

[0070] Within the scope of the present invention, the following compounds are the most preferred compounds:

[0071]

[0072] N-(4-(2,4-Dihydroxyphenyl)thiazol-2-yl)pivalamide

[0073]

[0074] N-(4-(2,4-Dihydroxyphenyl)thiazol-2-yl)isobutyramide

[0075]

[0076] N-(4-(2,4-Dihydroxyphenyl)thiazol-2-yl)butyramide

[0077]

[0078] N-(4-(2,4-Dihydroxyphenyl)thiazol-2-yl)heptanamide

[0079]

[0080] N-(4-(2,4-Dihydroxyphenyl)thiazol-2-yl)-6-hydroxyhexanamide

[0081]

[0082] N-(4-(2,4-Dihydroxyphenyl)thiazol-2-yl)-3-hydroxypropanamide

[0083]

[0084] N-(4-(2,4-Dihydroxyphenyl)thiazol-2-yl)-2-methoxyacetamide

[0085]

[0086] 3-Amino-N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)propanamide

[0087]

[0088] N-(4-(2,4-Dihydroxyphenyl)thiazol-2-yl)acetamide

[0089]

[0090] N-(4-(2,4-Dihydroxyphenyl)thiazol-2-yl)-4-(hydroxymethyl)cyclohexanecarboxamide

[0091]

[0092] N-(4-(2,4-Dihydroxyphenyl)thiazol-2-yl)cyclohexanecarboxamide

[0093] .

[0094] N-(4-(2,4-Dihydroxyphenyl)thiazol-2-yl)-2-(4-(hydroxymethyl)phenyl)acetamide

[0095] Cosmetic or dermatological preparations containing alkylamidothiazoles and their use for the treatment and / or prevention of undesired skin pigmentation are likewise advantageous embodiments of the present invention.

[0096] In particularly advantageous cases, such preparations contain, based on the total weight of the preparation, from 0.000001 to 10% by weight, in particular from 0.0001 to 3% by weight, very particularly from 0.001 to 1% by weight of one or more alkylamidothiazoles used according to the invention.

[0097] The cosmetic and dermatological preparations according to the invention can take various forms. Thus, they can be, for example, solutions, anhydrous preparations, emulsions or microemulsions of the water-in-oil (W / O) or oil-in-water (O / W) type, multiple emulsions such as water-in-oil-in-water type (W / O / W), gels, solid sticks, balms or aerosols. According to the invention, it is also advantageous to administer the substances and / or their derivatives used according to the invention in encapsulated form, for example in a collagen matrix and other customary encapsulation materials, for example as cellulose encapsulation, gelatin or liposome encapsulation.

[0098] In the context of the present invention, it is also possible and advantageous to add the substances used according to the invention and / or their derivatives to aqueous systems or surfactant preparations for cleaning the skin and hair.

[0099] The cosmetic and dermatological preparations according to the invention can contain cosmetic adjuvants customarily used in such preparations, such as preservatives, bactericides, fragrances, anti-foaming substances, dyes, pigments with a coloring effect, thickeners, surface-active substances, emulsifiers, softening, moisturizing and / or wetting substances, fats, oils, waxes or other customary components of cosmetic or dermatological formulations, such as alcohols, polyols, polymers, foam stabilizers, electrolytes, organic solvents or silicone derivatives.

[0100] The lipid phase can advantageously be selected from the following substances: mineral oil, mineral wax oil such as triglycerides of capric or caprylic acid, and natural oils such as castor oil; fats, waxes and other natural and synthetic fatty bodies, preferably esters of fatty acids with lower-carbon alcohols such as with isopropanol, propylene glycol or glycerol, or esters of fatty alcohols with lower-carbon chain alkanecarboxylic acids or fatty acids; alkyl benzoates; silicone oils, such as dimethylpolysiloxane, diethylpolysiloxane, diphenylpolysiloxane and mixtures thereof.

[0101] In the context of the present invention, the oil phase of emulsions, oil gels or aqueous or fat dispersions is advantageously selected from esters of saturated and / or unsaturated, branched and / or unbranched alkanoic acids with 3 to 30 C atoms and saturated and / or unsaturated, branched and / or unbranched alcohols with 3 to 30 C atoms, and esters of aromatic carboxylic acids with saturated and / or unsaturated, branched or unbranched alcohols with 3 to 30 C atoms. Thus, such ester oils can advantageously be selected from isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, isononyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate, 2-octyldodecyl palmitate, oleyl oleate, erucyl oleate, oleyl erucate, erucyl erucate, and synthetic, semi-synthetic and natural mixtures of such esters, such as jojoba oil.

[0102] The aqueous phase of the preparations according to the invention optionally advantageously contains wetting agents such as propylene glycol, panthenol or hyaluronic acid, and in particular one or more thickeners, which can advantageously be selected from silica, aluminum silicate, hydroxypropylmethyl cellulose, and particularly advantageously polyacrylates, such as Carbopol grade 980, which are used alone or in combination in each case.

[0103] In particular, mixtures of the above solvents are used. In the case of alcoholic solvents, water can be another component.

[0104] The emulsion according to the invention is advantageous and contains, for example, specific fats, oils, waxes and other fatty substances, as well as water and emulsifiers, as is common in formulations of this type.

[0105] The gel according to the invention generally contains, in the presence of a thickener, a lower alcohol such as ethanol, propylene glycol and water or the abovementioned oils, and the thickener is preferably silica or aluminum silicate in the case of an oil-alcohol gel and polyacrylate in the case of a water-alcohol gel or an alcohol gel.

[0106] Propellants suitable for the formulations according to the invention that can be sprayed from an aerosol container are generally known volatile liquefied propellants, such as hydrocarbons (propane, butane, isobutane), which can be used alone or in admixture with each other. Compressed air can also be advantageously used.

[0107] Advantageously, the formulations according to the invention can also advantageously contain substances that absorb UV radiation in the UVB region, and the total amount of the filter substance is, for example, from 0.1% to 30% by weight, preferably from 0.5% to 10% by weight, in particular from 1.0% to 6.0% by weight, based on the total weight of the formulation, to provide a cosmetic formulation that protects hair and / or skin from the entire ultraviolet radiation range. They can also act as a sunscreen for hair or skin.

[0108] In addition, the formulations according to the invention can advantageously additionally contain substances that mask the unpleasant inherent odor of the remaining raw materials used, and the total amount of the perfume component is, for example, from 0.001% to 30% by weight, preferably from 0.05% to 10% by weight, in particular from 0.1% to 5.0% by weight, based on the total weight of the formulation, in order to provide a cosmetic formulation.

[0109] A very advantageous composition according to the invention contains:

[0110] - isobutylamidothiazolylresorcinol in an amount of 0.01% to 0.2%;

[0111] - niacinamide in an amount of 0.01% to 3%;

[0112] - diethylhexyl sylacate + triglyceride of caprylic / capric acid in an amount of 0.01% to 0.15%;

[0113] - sodium hyaluronate, xanthan gum, gellan gum in an amount of 0.01% to 0.2%;

[0114] - PEG-40 hydrogenated castor oil in an amount of 0.01% to 5%;

[0115] - alcohol in an amount of 5% to 20%.

[0116] The following examples are intended to illustrate the invention without limiting the invention. Unless otherwise indicated, all amounts, fractions, and percentages are based on the weight and total amount or total weight of the preparation.

[0117]

Claims

1. An active ingredient combination of a) one or more alkylamidothiazoles and b) diethylhexyl syringylidenemalonate in c) a cosmetic vehicle.

2. A cosmetic preparation comprising the combination according to claim 1.

3. A method of using an active ingredient combination of b) diethylhexyl syringylidenemalonate for preventing or reducing the degradation of alkylamidothiazoles caused by oxidative processes and / or heat and / or UV light in cosmetic preparations containing one or more alkylamidothiazoles.

4. The cosmetic preparation according to claim 2 or the method of use according to claim 3, characterized in that To provide a cosmetic preparation, the total amount of the one or more alkylamidothiazoles is, for example, 0.00001% to 10% by weight, preferably 0.001% to 5% by weight, in particular 0.005% to 3% by weight, based on the total weight of the preparation.

5. The cosmetic preparation according to any one of the preceding claims, characterized in that In order to provide a cosmetic preparation, the total amount of diethylhexyl syringylidenemalonate is, for example, 0.00001% to 10% by weight, preferably 0.001% to 5% by weight, and in particular 0.005% to 3% by weight, based on the total weight of the preparation.

6. The cosmetic preparation according to any one of the preceding claims, characterized in that It further comprises niacinamide, in order to provide a cosmetic preparation, in a total amount of, for example, 0.00001% to 10% by weight, preferably 0.001% to 5% by weight, in particular 0.005% to 3% by weight, based on the total weight of the preparation.

7. The cosmetic preparation according to any one of the preceding claims, characterized in that It further comprises alpha-tocopherol, in order to provide a cosmetic preparation, in a total amount of, for example, 0.00001% to 10% by weight, preferably 0.001% to 5% by weight, in particular 0.005% to 3% by weight, based on the total weight of the preparation.

8. The cosmetic preparation according to any one of the preceding claims, characterized in that It further comprises β-tocopherol, in order to provide a cosmetic preparation, in a total amount of, for example, 0.00001% to 10% by weight, preferably 0.001% to 5% by weight, in particular 0.005% to 3% by weight, based on the total weight of the preparation.

9. The cosmetic preparation according to any one of the preceding claims, characterized in that It further comprises dimethylmethoxychromanol in a total amount of, for example, 0.00001% to 10% by weight, preferably 0.001% to 5% by weight, in particular 0.005% to 3% by weight, based on the total weight of the preparation, in order to provide the cosmetic preparation.

10. The cosmetic preparation according to any one of the preceding claims, characterized in that They contain less than about 1.5 wt % of one or more hydrocolloids, such as no more than about 1.0 wt % of one or more hydrocolloids and / or at least about 0.1 wt % of one or more hydrocolloids, based on the total weight of the formulation.

11. The active ingredient combination or cosmetic preparation according to any one of the preceding claims, characterized in that The one or more alkylamidothiazoles are selected from the following: N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)pivalamide N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)isobutyramide N-(4-(2,4-Dihydroxyphenyl)thiazol-2-yl)butanamide N-(4-(2,4-Dihydroxyphenyl)thiazol-2-yl)heptylamide N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)-6-hydroxyhexanamide N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)-3-hydroxypropanamide N-(4-(2,4-Dihydroxyphenyl)thiazol-2-yl)-2-methoxyacetamide 3-Amino-N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)propanamide N-(4-(2,4-Dihydroxyphenyl)thiazol-2-yl)acetamide N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)-4-(hydroxymethyl)cyclohexanecarboxamide N-(4-(2,4-Dihydroxyphenyl)thiazol-2-yl)cyclohexanecarboxamide N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)-2-(4-(hydroxymethyl)phenyl)acetamide.

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