Centella asiatica essence and production process thereof

Abstract

The invention relates to the technical field of centella asiatica essence, and discloses centella asiatica essence which is characterized by comprising the following components in percentage by mass: 89.9% of water, 89.9% of 1, 2, 4-trimethyl-1, 3-pentanediol monoisobutyrate, 89.9% of sodium dodecyl benzene sulfonate 3% of 3-ButyleneGlycol1, 1% of LJ-Diol, 1% of PA-408, 1% of beta-glucan, 0.6% of # imgabs0 # HV50, 0.55% of Methyl Gluceth E10KCH, 0.4% of edible alcohol, 0.4% of KMO-6, 0.4% of # imgabs1 # H, 0.4% of annoine, 0.3% of MSP fructo-oligosaccharide QHT-MSP-1000S, 0.3% of Royantin TP-2 anti-allergy factor, 0.3% of # imgabs2 #, 0.15% of AQUPEC HV-505E, 0.15% of L-arginine, 0.03% of dipotassium glycyrrhizinate, 0.03% of natrosol TM250hhr pc hydroxyethellulose According to the centella asiatica essence and the production process thereof, various components have a synergistic effect, so that the product can achieve multiple effects and meet the complex nursing requirements of sensitive skin.

Description

Technical Field

[0001] The present invention relates to the technical field of centella asiatica essence, and specifically to a centella asiatica essence and its production process. Background Art

[0002] Currently, most soothing essences on the market use single plant extracts (such as asiaticoside, chamomile extract) or basic moisturizers (such as hyaluronic acid, glycerin) as the main active ingredients and are prepared by traditional high-temperature emulsification processes. Although such products can provide certain moisturizing and anti-inflammatory effects under normal temperature storage conditions, their ingredient systems are relatively single, making it difficult to comprehensively meet the complex needs of sensitive skin. Existing technologies usually rely on alcohol or synthetic esters to adjust the skin feel and add preservatives to maintain the system stability, resulting in potential irritation risks in the products. Moreover, the high-temperature process is likely to damage the biological activities of thermosensitive ingredients (such as plant polyphenols, hyaluronic acid), affecting the sustainability of the product efficacy.

[0003] The formula designs of existing soothing essences generally have the problem of single active ingredients, leading to significant limitations in product efficacy. For example, most products only add centella asiatica extract as the core soothing ingredient, and its main active ingredient is asiaticoside. Although it can relieve flushing by inhibiting the expression of inflammatory factors, its effect on skin barrier repair and moisture locking is weak. For products mainly composed of chamomile extract, although they contain flavonoids with antioxidant properties, their effect on relieving the burning sensation common in sensitive skin is limited. In addition, some formulas only rely on basic moisturizers such as hyaluronic acid, which can improve dryness in the short term but cannot solve the persistent sensitivity problems caused by damaged barriers. Such a single-ingredient formula system makes it difficult for products to simultaneously cover multiple efficacy requirements such as inflammation inhibition, barrier repair, moisture locking, and antioxidant, resulting in consumers having to use multiple products in combination to meet the complex care needs of sensitive skin, which not only increases the usage cost but also may cause new irritation risks due to ingredient stacking. Therefore, we have proposed a centella asiatica essence and its production process. Summary of the Invention

[0004] (I) Technical Problems to be Solved

[0005] In view of the deficiencies of the prior art, the present invention provides a centella asiatica essence and its production process, which have the advantages of multiple-component synergy, mildness and low irritation, comprehensive and lasting efficacy, etc., and solve the problems of single active ingredients, limited efficacy, irritation risks, and easy inactivation of thermosensitive ingredients in existing soothing essences.

[0006] (II) Technical Solutions

[0007] To achieve the above purposes of multiple-component synergy, mildness and low irritation, and comprehensive and lasting efficacy, the present invention provides the following technical solutions:

[0008] A centella asiatica essence, comprising the following components in mass ratio: water 89.9%, 1,3-ButyleneGlycol 3%, LJ-Diol 1%, PA-408 1%, β-glucan 1%, HV500.6%, Methyl Gluceth E10KCH0.55%, edible alcohol 0.4%, KMO-6 0.4%, H0.4%, annouin 0.4%, MSP oligofructose QHT-MSP-1000S 0.3%, Royantin TP-2 anti-allergy factor 0.3%, 0.3%, AQUPEC HV-505E 0.15%, L-arginine 0.15%, dipotassium glycyrrhizinate 0.03%, natrosol TM 250hhrpc hydroxyethylcellulose 0.03%, Jarpro ET ectoin 0.03%, piper methysticum 0.02%, asiaticoside-II 0.02%, moistuHA sodium hyaluronate 0.01%, RH40 0.008%, FA27615 light fragrance 0.002%.

[0009] Preferably, the concentration of the dipotassium glycyrrhizinate is 70%.

[0010] Preferably, the sensory indicators of the essence include: the pH value is between 5 and 7, there is no delamination after maintaining at 40±1°C for 24 hours and then returning to room temperature, and there is no delamination, coarsening, or color change after maintaining at -8±2°C for 24 hours and then returning to room temperature.

[0011] Preferably, the sensory indicators of the essence include: the total number of bacteria does not exceed 1000 CFU / g, the total number of molds and yeasts does not exceed 100 CFU / g, fecal coliforms, Staphylococcus aureus, and Pseudomonas aeruginosa are not detected, the lead content does not exceed 10 mg / kg, the arsenic content does not exceed 2 mg / kg, the mercury content does not exceed 1 mg / kg, and the cadmium content does not exceed 5 mg / kg.

[0012] A production process of a centella asiatica essence, including the centella asiatica essence, and further comprising the following steps:

[0013] S1. Add water, AQUPEC HV-505E, and natrosol TM 250hhrpchydroxyethylcellulose into the water pot in sequence. After dissolution, add 1,3-ButyleneGlycol, LJ-Diol, PA-408, β-glucan, HV50, KMO-6, H, Anoyn, MSP Fructooligosaccharide QHT-MSP-1000S, Dipotassium Glycyrrhizinate, Jarpro ET Ectoin, Asiaticoside-II, moishtuHA Sodium Hyaluronate, heat up to 85 ± 2 °C;

[0014] S2. Transfer to an emulsifying pan, keep warm for 10 minutes, then cool down to about 55 °C, add Methyl Gluceth E10KCH, Edible Alcohol (Extra Grade), Royantin TP-2 Anti-allergy Factor, L-Arginine, Piper methysticum, and pre-mixed RH40 and FA27615 Asakusa;

[0015] S3. Cool down to 45 °C, filter and discharge after passing the inspection, and fill and store in the warehouse after semi-finished product inspection.

[0016] (III) Beneficial Effects

[0017] Compared with the prior art, the present invention provides a centella asiatica essence and its production process, which have the following beneficial effects:

[0018] 1. The centella asiatica essence and its production process contain a variety of active ingredients, such as Asiaticoside-II, Ectoin, β-Glucan, etc. Asiaticoside-II inhibits the expression of inflammatory factors and relieves flushing. Ectoin promotes the synthesis of filaggrin to repair the skin barrier. β-Glucan has a moisturizing effect. The synergistic effect of multiple ingredients enables the product to simultaneously achieve multiple effects such as inflammation inhibition, barrier repair, and moisturizing and water locking, meeting the complex care needs of sensitive skin.

[0019] 2. The centella asiatica essence and its production process do not rely on alcohol or synthetic esters to adjust the skin feel in the formula, nor use traditional high-risk preservatives. Instead, it uses Caprylohydroxamic Acid (KMO-6) and Hexylene Glycol ( H) for compound bacteriostasis. This mild formula design avoids sensitive problems caused by strong ingredient irritation. While meeting the skin care needs, it reduces the risk of irritation to sensitive skin and ensures the use safety. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is a schematic diagram of the production process flow of the centella asiatica essence of the present invention. DETAILED DESCRIPTION OF THE INVENTION

[0021] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the embodiments and drawings of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0022] Please refer to Figure 1 , a centella asiatica essence, comprising the following components in mass ratio: water 89.9%, 1,3-Butylene Glycol 3%, LJ-Diol 1%, PA-408 1%, β-glucan 1%, HV50 0.6%, Methyl Gluceth E10KCH 0.55%, edible alcohol 0.4%, KMO-6 0.4%, H 0.4%, annouin 0.4%, MSP oligofructose QHT-MSP-1000S 0.3%, Royantin TP-2 anti-allergy factor 0.3%, 0.3%, AQUPEC HV-505E 0.15%, L-arginine 0.15%, dipotassium glycyrrhizinate 0.03%, natrosol TM 250hhrpc hydroxyethylcellulose 0.03%, Jarpro ET ectoin 0.03%, kava pepper 0.02%, asiaticoside-II 0.02%, moistuHA sodium hyaluronate 0.01%, RH40 0.008%, FA27615 light fragrance 0.002%.

[0023] A production process of centella asiatica essence, including centella asiatica essence, further comprising the following steps:

[0024] S1. Add water, AQUPEC HV-505E, natrosol TM 250hhr pchydroxyethylcellulose into the water pot in sequence. After dissolution, add 1,3-Butylene Glycol, LJ-Diol, PA-408, β-glucan, HV50, KMO-6, H, annouin, MSP oligofructose QHT-MSP-1000S, dipotassium glycyrrhizinate, Jarpro ET ectoin, asiaticoside-II, moistuHA sodium hyaluronate, and heat up to 85 ± 2 °C;

[0025] S2. Transfer to the emulsifying pot, keep warm for 10 minutes, then cool down to about 55 °C, and add Methyl Gluceth E10KCH, edible alcohol (special grade), Royantin TP-2 anti-allergy factor, L-arginine, kava pepper and premixed RH40 and FA27615 light fragrance;

[0026] S3. Cool down to 45 °C, filter and discharge after passing the inspection, and fill and store in the warehouse after semi-finished product inspection.

[0027] Example 1:

[0028] This embodiment elaborates in detail the production process of Centella asiatica essence. First, prepare various equipment required for production, such as a water pot with precise temperature control and stirring functions. Its temperature control accuracy can reach ±1°C, and the stirring speed can be precisely adjusted within the range of 10 - 50 revolutions per minute. The water used is deionized water that has undergone multiple filtration and purification processes to ensure high purity and few impurities.

[0029] In the water pot, add the ingredients in a precise order. First, add water, AQUPEC HV - 505E, and natrosol TM 250hhr pc hydroxyethylcellulose, turn on the stirring device, and stir at a speed of 15 revolutions per minute to allow them to dissolve fully. This process lasts about 30 minutes. During this period, closely observe the dissolution situation to ensure there is no caking phenomenon. Subsequently, add various ingredients such as 1,3 - ButyleneGlycol, LJ - Diol, and PA - 408 in sequence. For each added ingredient, stir appropriately to make it evenly dispersed. After the addition is completed, slowly raise the temperature of the water pot to 85°C, and strictly control the temperature fluctuation within the range of ±2°C during the heating process. This heating process takes about 30 - 40 minutes.

[0030] When the temperature reaches 85°C, transfer the mixture to the emulsifying pot. In the emulsifying pot, maintain the temperature at 85°C and continue stirring for 10 minutes, with the stirring speed controlled at about 25 revolutions per minute to further blend the various ingredients. Then, start to cool down. By adjusting the cooling device, lower the temperature to about 55°C. During the cooling process, add ingredients such as Methyl GlucethE10KCH, food - grade alcohol (special grade), and Royantin TP - 2 anti - allergy factor in accordance with the formula. Among them, RH40 and FA27615 Asakusa need to be pre - mixed evenly before adding.

[0031] Finally, when the temperature drops to 45°C, conduct a comprehensive inspection of the mixture. The inspection items include ingredient content, pH value, microbial indicators, etc. Only after all indicators meet the requirements can it be filtered and discharged. The filtration uses a high - precision filter screen with a pore size of 0.22 microns, which can effectively remove tiny impurities. After the semi - finished product passes the inspection, it is aseptically filled into packaging containers that have undergone strict disinfection treatment, and then stored in the warehouse.

[0032] Example Two:

[0033] Temperature control has an important impact on the quality and performance of the centella asiatica essence. In stage S1, a gradient heating strategy is adopted. First, the temperature is raised from 25°C to 60°C at a rate of 5°C per minute, and then it is heated to 85°C at a rate of 2°C per minute. Such a gradient heating method allows various components to gradually adapt to temperature changes, avoiding component inactivation or abnormal reactions caused by sudden temperature increases. In stage S2, the cooling process is also crucial. When cooling from 85°C to 55°C, it is rapidly cooled at a rate of 3°C per minute to form a primary mixed structure; then when cooling from 55°C to 45°C, it is slowly cooled at a rate of 1°C per minute to promote the orderly arrangement of components and improve the stability and uniformity of the product.

[0034] The stirring parameters also vary in different production stages. In the dissolution stage, in order to fully dissolve various components without generating excessive bubbles, a laminar flow stirring method is adopted, and the Reynolds number (Re) is controlled between 500 - 800. In the emulsification stage, to fully mix various components to form a stable emulsion structure, turbulent stirring is used, and Re is controlled within the range of 2000 - 3000. In the post-treatment stage, to avoid damaging the formed emulsion structure, the gentle mixing method is adopted, and Re is maintained between 300 - 500.

[0035] To ensure the sterility of the product, a combined process of moist heat sterilization (121°C, 15 minutes) and terminal filtration is adopted. During the sterilization process, a biological indicator challenge test is carried out, and Bacillus stearothermophilus (ATCC7953) is selected as the indicator bacterium. After verification, this process can achieve a killing rate of Bacillus stearothermophilus ≥ 10^6, effectively ensuring the microbial safety of the product.

[0036] Example Three:

[0037] To ensure the quality stability of the centella asiatica essence, a comprehensive stability test plan is formulated. The accelerated test is to place the product in an environment of 40°C ± 2°C and relative humidity of 75% ± 5% for 3 months. During this process, the appearance, pH value, component content and other indicators of the product are regularly detected to observe whether phenomena such as layering, discoloration, and deterioration occur. The low-temperature test is to place the product at -8°C ± 2°C for 24 hours and then restore it to room temperature, and this cycle is carried out 3 times to check whether there are problems such as layering, coarsening, and discoloration. The centrifugation test is to centrifuge the product at a speed of 3000 revolutions per minute for 30 minutes to observe whether there is layering, so as to evaluate the physical stability of the product.

[0038] The microbial limit standard is an important indicator for measuring product quality. The total aerobic bacteria count is required to be no more than 100 CFU per gram of the product (in accordance with General Rule 1105 of the Fourth Part of the Pharmacopoeia), and the total count of fungi and yeasts is no more than 10 CFU per gram. At the same time, it is strictly controlled that harmful microorganisms such as Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus are not detected, so as to ensure the safety of the product and avoid adverse effects such as skin infection on users.

[0039] Example 4:

[0040] In daily use, first, thoroughly clean the facial skin to remove dirt and oil. Then, take 2 - 3 drops (about 0.15 - 0.2 ml) of centella asiatica essence and evenly apply it on the face, paying attention to avoiding the skin around the eyes because the skin around the eyes is more sensitive and may have an adverse reaction to the product. After application, gently massage the face with the fingertips for about 30 seconds to help the product be better absorbed by the skin. It is recommended to use it once in the morning and once in the evening every day to continuously exert the efficacy of the product.

[0041] In special usage scenarios, the usage method is different. When the skin is in the sensitive outbreak period, the centella asiatica essence can be put in the refrigerator for refrigeration (stored at 4°C). The refrigerated product will bring a cooler feeling to the skin when used, which helps to relieve sensitive symptoms, but it should be noted that the refrigerated storage time does not exceed 7 days. After laser treatment, the skin is in a relatively fragile state. At this time, the centella asiatica essence can be poured on a sterile gauze, and then the gauze can be wet compress on the face for about 10 minutes each time, which can help repair the damaged skin. During the seasonal sensitive period, the skin has poor tolerance. The centella asiatica essence can be mixed with a moisturizing cream in a ratio of 1:1 and then used to enhance the skin's moisturizing and protective capabilities.

[0042] In summary, the centella asiatica essence and its production process contain a variety of active ingredients, such as asiaticoside - II, ectoin, β - glucan, etc. Asiaticoside - II inhibits the expression of inflammatory factors and relieves flushing. Ectoin promotes the synthesis of filaggrin to repair the skin barrier. β - glucan has a moisturizing effect. The synergistic effect of multiple ingredients enables the product to simultaneously achieve multiple effects such as inflammation inhibition, barrier repair, and moisturizing and water - locking, meeting the complex care needs of sensitive skin.

[0043] Moreover, the centella asiatica essence and its production process do not rely on alcohol or synthetic esters to adjust the skin feel in the formula, nor use traditional high - risk preservatives. Instead, it uses octanoyl hydroxamic acid (KMO - 6) and hexylene glycol ( H) Compound bacteriostasis. This mild formulation design avoids the problem of sensitivity caused by strong ingredient irritation. While meeting the skin care needs, it reduces the risk of irritation to sensitive skin, ensures the safety of use, and solves the problems of single active ingredient, limited efficacy, irritation risk, and easy inactivation of thermosensitive ingredients in existing soothing essence.

[0044] The relevant modules involved in this system are all hardware system modules or functional modules that combine computer software programs or protocols in the prior art with hardware. The computer software programs or protocols themselves involved in this functional module are all well-known technologies to those skilled in the art, and they are not the improvements of this system; the improvement of this system is the interaction relationship or connection relationship between each module, that is, the overall structure of the system is improved to solve the corresponding technical problems to be solved by this system.

[0045] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Centella asiatica essence, characterized in that: The composition includes the following mass ratios: water 89.9%, 1,3-ButyleneGlycol 3%, LJ-Diol 1%, PA-4081%, β-glucan 1%, HV500.6%, Methyl Gluceth E10KCH0.55%, Edible Alcohol 0.4%, KMO-60.4%, H0.4%, Annoin 0.4%, MSP oligofructose QHT-MSP-1000S 0.3%, Royantin TP-2 anti-allergic factor 0.3%, 0.3%, AQUPEC HV-505E 0.15%, L-arginine 0.15%, dipotassium glycyrrhizinate 0.03%, natrosol TM 250hhrpc hydroxyethylcellulose 0.03%, Jarpro ET ectoine 0.03%, kava pepper 0.02%, Centella asiatica-Ⅱ 0.02%, moistuHA sodium hyaluronate 0.01%, RH40 0.008%, FA27615 light fragrance 0.002%.

2. The Centella asiatica essence according to claim 1, characterized in that: The concentration of the dipotassium glycyrrhizinate is 70%.

3. The Centella asiatica essence according to claim 1, characterized in that: The sensory indicators of the essence include: pH value between 5 and 7, no stratification after being kept at 40±1℃ for 24 hours and then returned to room temperature, and no stratification, coarsening or discoloration after being kept at -8±2℃ for 24 hours and then returned to room temperature.

4. The Centella asiatica essence according to claim 1, characterized in that: The sensory indicators of the essence include: the total bacterial count does not exceed 1000 CFU / g, the total mold and yeast count does not exceed 100 CFU / g, fecal coliform group, Staphylococcus aureus and Pseudomonas aeruginosa shall not be detected, the lead content does not exceed 10 mg / kg, the arsenic content does not exceed 2 mg / kg, the mercury content does not exceed 1 mg / kg, and the cadmium content does not exceed 5 mg / kg.

5. A production process of Centella asiatica essence, characterized in that: The Centella asiatica extract according to claim 1-4 further comprises the following steps: S1. Add water, AQUPEC HV-505E, and natrosol to the water pot in sequence. TM After 250hhr pchydroxyethylcellulose is dissolved, add 1,3-ButyleneGlycol, LJ-Diol, PA-408, β-glucan, HV50, KMO-6, H, Annoin, MSP oligofructose QHT-MSP-1000S, dipotassium glycyrrhizinate, Jarpro ET ectoin, asiaticaside-Ⅱ, moistuHA sodium hyaluronate, heated to 85±2℃; S2, transfer to the emulsifying pot and keep warm for 10 minutes, then cool to about 55°C, add Methyl Gluceth E10KCH, edible alcohol (special grade), Royantin TP-2 anti-allergic factor, L-arginine, kava, and pre-mixed RH40 and FA27615 light aroma; S3. Cool down to 45℃ and filter out the material after passing the test. Fill and store after semi-finished product testing.

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