Calibration method and sample analysis system

Abstract

The invention provides a calibration method and a sample analysis system. The method comprises the following steps: evaluating a calibration state of a detection reagent; and for the target detection reagent of which the calibration state accords with the preset state, generating a calibration task of the target detection reagent by a control device of the sample analyzer. The calibration task can be generated in time for the target detection reagent with the calibration state meeting the preset state, a user does not need to check which detection reagents need to be calibrated by himself or herself, the user does not need to manually generate the calibration task, user operation is reduced, and the timeliness of calibration of the detection reagents is improved.

Description

Technical Field

[0001] The present invention relates to the field of control technology, and particularly to a calibration method and a sample analysis system. Background Art

[0002] In the related art, a sample analyzer is an instrument that analyzes a blood sample using a detection reagent. In the detection, a detection reagent corresponding to the substance to be detected in the blood sample is used to detect the concentration of the substance to be detected. The detection reagent is mixed with the blood sample to produce a biochemical reaction and emit a light signal, and the intensity of the light signal can reflect the concentration of the substance to be detected. According to the conversion curve between the light signal intensity value stored in the sample analyzer and the concentration of the substance to be detected, the concentration of the substance to be detected in the blood sample can be calculated.

[0003] The conversion curve is obtained by using the detection reagent to detect calibration products with multiple different standard concentrations. This process can be regarded as the calibration of the detection reagent. When calibrating the detection reagent, a calibration product with a known concentration is mixed with the detection reagent to produce a light signal, and the generated light signal is used as the standard signal value corresponding to the concentration of the calibration product. By using the detection reagent to detect calibration products with different concentration gradients in sequence to obtain corresponding multiple light signal intensity values, the multiple light signal intensity values are the light signal intensity values generated when the detection reagent detects samples to be detected with different concentrations, so as to obtain the conversion curve between the light signal intensity value and the concentration of the sample to be detected. The obtained conversion curve is also called a calibration curve.

[0004] All detection reagents used in the sample analyzer must be calibrated first before they can be normally used for the detection test of samples to be detected. Moreover, the calibration curve is not valid for a long time. Usually, one calibration can only ensure the validity of the detection results for a certain period, such as 28 days. After the validity period of the calibration curve is exceeded, the same detection reagent needs to be calibrated again. In the related art, it is necessary for the user to manually check and identify which detection reagent needs to be calibrated, manually generate and execute the calibration task, the operation is cumbersome, the user experience is poor, and the detection reagent cannot be calibrated in time.

[0005] Therefore, a new calibration method is needed. Summary of the Invention

[0006] The main object of the present invention is to provide a calibration method and a sample analysis system to achieve automatic calibration of the detection reagent.

[0007] The present invention provides a calibration method for a sample analyzer that uses a detection reagent to detect the concentration of a specific substance in a blood sample, including: obtaining calibration information of the detection reagent loaded in the reagent cassette of the sample analyzer, and evaluating the calibration status of the detection reagent according to the calibration information; for a target detection reagent whose calibration status meets a preset status, generating a calibration task for the target detection reagent by a control device of the sample analyzer.

[0008] In one embodiment, it further includes: obtaining identification information of the detection reagent loaded in the reagent cassette of the sample analyzer through an identification reading device, and / or retrieving identification information of the detection reagent loaded in the reagent cassette of the sample analyzer from a database; obtaining calibration information of the detection reagent loaded in the reagent cassette of the sample analyzer, including: retrieving calibration information of the detection reagent loaded in the reagent cassette of the sample analyzer from the database according to the identification information.

[0009] In one embodiment, in the case of a preset trigger event occurring, then retrieving calibration information of the detection reagent loaded in the reagent cassette of the sample analyzer from the database, where the preset trigger event includes at least one of the following: after receiving a startup signal of the control software, first obtaining identification information of the detection reagent loaded in the reagent cassette of the sample analyzer; after receiving a power-on signal of the sample analyzer or after receiving an enabling signal for the sample analyzer to switch to the enabled state, first obtaining identification information of the detection reagent loaded in the reagent cassette of the sample analyzer; receiving a loading signal for a newly loaded detection reagent in the reagent cassette of the sample analyzer; and receiving an enabling signal for the detection reagent in the reagent cassette of the sample analyzer to switch to the enabled state.

[0010] In one embodiment, the calibration information includes a calibration curve of the detection reagent and the validity period of the calibration curve; evaluating the calibration status of the detection reagent according to the calibration information includes: in the case where the calibration information includes a calibration curve, and the validity period of the calibration curve is greater than 0 and does not exceed a preset duration, evaluating the calibration status of the detection reagent as about to expire; in the case where the calibration information includes a calibration curve and the validity period of the calibration curve does not exceed 0, or in the case where the calibration information does not include a calibration curve, evaluating the calibration status of the detection reagent as invalid; the preset status includes at least one of the following: about to expire and invalid.

[0011] In one embodiment, for a target detection reagent whose calibration status meets a preset status, a calibration task for the target detection reagent is generated by a control device of the sample analyzer, including: when the calibration status is invalid, a first calibration task for the target detection reagent is generated by the control device of the sample analyzer; and / or when the calibration status is about to expire, a second calibration task for the target detection reagent is generated by the control device of the sample analyzer.

[0012] In one embodiment, it further includes: after generating the second calibration task, monitoring the remaining validity period of the target detection reagent, and when the remaining validity period is equal to 0, switching the second calibration task of the target detection reagent to a first calibration task.

[0013] In one embodiment, it further includes: when generating the first calibration task, setting the available status of detection reagents with the same identification information as the target detection reagent corresponding to the first calibration task to a disabled status.

[0014] In one embodiment, it further includes: based on the first calibration task and / or the second calibration task to be executed, retrieving in a database a standard sample corresponding to the first calibration task and / or the second calibration task loaded in a sample bin and its location information; calling the standard sample according to the location information of the standard sample, and executing the corresponding first calibration task and / or the second calibration task to generate calibration information of the target detection reagent corresponding to the first calibration task and / or the second calibration task.

[0015] In one embodiment, the location information of a newly loaded standard sample in the sample bin is obtained through a label reading device, and the location information of the newly loaded standard sample is associated and stored in the database with the corresponding standard sample.

[0016] In one embodiment, the calibration method is executed according to a preset period.

[0017] The present invention provides a sample analysis system, including: a computing device including a processor and a memory, where a computer program is stored in the memory, and when the computer program is executed by the processor, the steps of the above calibration method are implemented; at least one sample analyzer for executing a calibration task according to a control instruction of the computing device.

[0018] Through the calibration method of the present invention, a calibration task can be timely generated for a target detection reagent whose calibration status meets a preset status, without the need for the user to check by themselves which detection reagents need to be calibrated, nor the need for the user to manually generate a calibration task, reducing user operations and being beneficial to improving the timeliness of calibrating detection reagents. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] The accompanying drawings of the specification, which form a part of this application, are used to provide a further understanding of the present invention. The schematic embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an improper limitation of the present invention. In the drawings:

[0020] Figure 1 is a flowchart of a calibration method according to an embodiment of the present application;

[0021] Figure 2 is a schematic diagram of a calibration task display interface according to an embodiment of the present application;

[0022] Figure 3 is a schematic diagram of a control for executing a calibration task on a calibration task display interface according to an embodiment of the present application;

[0023] Figure 4 is a schematic structural diagram of a calibration system according to an embodiment of the present application. Detailed Embodiments

[0024] It should be noted that, without conflict, the embodiments in this application and the features in the embodiments may be combined with each other. The present invention will be described in detail below with reference to the accompanying drawings and in conjunction with the embodiments.

[0025] In the related art, the calibration of detection reagents is carried out according to the following steps:

[0026] 1. The user checks which detection reagents on the sample analyzer need to perform calibration tasks;

[0027] 2. The user manually adds the calibration tasks to be performed in the calibration interface of the software;

[0028] 3. After adding the calibration tasks, the user switches to the work order interface and places the corresponding calibration products at the specified positions;

[0029] 4. The user manually clicks to submit;

[0030] 5. The sample analyzer executes the submitted calibration tasks;

[0031] 6. A calibration curve is generated after the calibration tasks are completed.

[0032] In the related art, it is necessary for the user to personally check and judge which detection reagents need to be calibrated. For the detection reagents that need to be calibrated, most of the steps of the calibration operation need to be performed manually by the user, which is a cumbersome process, neither intelligent nor convenient, and the user experience is poor.

[0033] Reference Figure 1, this embodiment provides a calibration method for a sample analyzer that uses a detection reagent to detect the concentration of a specific substance in a blood sample, which may include: obtaining calibration information of the detection reagent loaded in the reagent compartment of the sample analyzer, and evaluating the calibration status of the detection reagent according to the calibration information; for a target detection reagent whose calibration status meets a preset status, generating a calibration task for the target detection reagent by the control device of the sample analyzer.

[0034] The sample analyzer can be a biochemical analyzer, a chemiluminescence analyzer, a cell analyzer, a urine analyzer, a coagulation analyzer, etc. Further, the sample analyzer can be a sample analyzer based on different detection methodologies, such as a biochemical analyzer based on latex turbidimetry, a chemiluminescence analyzer based on enzyme-linked immunosorbent assay, a chemiluminescence analyzer based on luminescent oxygen channeling immunoassay. The control device of the sample analyzer can include one or more terminal devices, and each terminal device can control one or more sample analyzers. The terminal device can include any computing device with computing functions such as a desktop computer, a laptop computer, a tablet computer, a mobile phone, etc. The method of the present invention can be applied to a sample analyzer or other analytical and detection instruments that need to calibrate the detection reagent, and the present application does not make specific limitations thereto. Data communication connections in wired or wireless forms can be established between the terminal device and the sample analyzer, and between multiple terminal devices, through a local area network or a wide area network, and those skilled in the art can make specific settings according to needs.

[0035] In this embodiment, the calibration status of the detection reagent can be evaluated manually, can be evaluated according to the category of the detection reagent, and can also be evaluated according to the loading time of the detection reagent, which is not limited herein. The calibration status of the detection reagent can, for example, include about to be valid, valid, about to expire, and invalid, etc., and the preset status can, for example, include about to be valid, expired, and invalid, etc., and the present application is not limited thereto. Generating a calibration task for the target detection reagent by the control device of the sample analyzer can, for example, generate a calibration task that needs to be executed on the operation interface of the software, or directly generate a work order for the calibration task, which is not limited herein.

[0036] In this embodiment, the calibration information of the detection reagent can, for example, include: the personnel number for calibrating the detection reagent, the calibration date, the batch code of the standard sample used for calibration, etc., and can also include the calibration curve of the detection reagent and the validity period of the calibration curve, etc. Evaluating the calibration status of the detection reagent according to the calibration information can, for example, stipulate that the calibration status of certain batch-coded detection reagents is invalid, and can stipulate that the calibration status of certain personnel-numbered detection reagents is valid, etc., which is not limited herein.

[0037] Through the calibration method of this embodiment, calibration tasks can be generated in a timely manner for target detection reagents whose calibration status meets the preset status, without the need for users to check which detection reagents need to be calibrated by themselves, nor for users to manually generate calibration tasks, reducing user operations and facilitating the improvement of the timeliness of calibrating detection reagents.

[0038] In one embodiment, the method may further include: retrieving the calibration information of the detection reagents loaded in the reagent magazine of the sample analyzer from the database, and evaluating the calibration status of the detection reagents according to the calibration information.

[0039] In one embodiment, the method may further include: obtaining the identification information of the detection reagents loaded in the reagent magazine of the sample analyzer through an identification reading device, and / or retrieving the identification information of the detection reagents loaded in the reagent magazine of the sample analyzer from the database; obtaining the calibration information of the detection reagents loaded in the reagent magazine of the sample analyzer, including: retrieving the calibration information of the detection reagents loaded in the reagent magazine of the sample analyzer from the database according to the identification information.

[0040] In this embodiment, the identification information may include information such as the production batch, manufacturer, and origin of the detection reagent. For example, the identification information may be a batch code, etc. Even for detection reagents with the same composition, detection reagents with different batch codes may need to be calibrated separately. For newly loaded detection reagents in the reagent magazine of the sample analyzer, the identification information of the newly loaded detection reagents can be obtained through an identification reading device; for the detection reagents originally loaded in the reagent magazine of the sample analyzer, it is possible that the identification information of these detection reagents has been read when these detection reagents were first loaded into the reagent magazine of the sample analyzer, so that the identification information of these detection reagents can be directly retrieved from the database, or the identification information of these detection reagents can be read through an identification reading device, which is not limited here.

[0041] In this embodiment, the identification reading device can obtain the identification information of the detection reagents by scanning label information such as barcodes and two-dimensional codes of the detection reagents loaded in the reagent magazine. Among them, the identification reading device may include, for example, a barcode scanner; the calibration information of the detection reagents can be obtained by scanning the barcodes and two-dimensional codes of the detection reagents, or the calibration information of the detection reagents can be directly retrieved from the database according to the identification information of the detection reagents, which is not specifically limited here.

[0042] In one embodiment, when a preset trigger event occurs, calibration information of the detection reagent loaded in the reagent cartridge of the sample analyzer is retrieved from the database according to the identification information. The preset trigger event includes at least one of the following: after receiving the start signal of the control software, for the first time obtaining the identification information of the detection reagent loaded in the reagent cartridge of the sample analyzer; after receiving the power-on signal of the sample analyzer or after receiving the enable signal for the sample analyzer to switch to the enabled state, for the first time obtaining the identification information of the detection reagent loaded in the reagent cartridge of the sample analyzer; receiving the loading signal for a newly loaded detection reagent in the reagent cartridge of the sample analyzer; and receiving the enable signal for the detection reagent in the reagent cartridge of the sample analyzer to switch to the enabled state.

[0043] In this embodiment, retrieving the calibration information of the detection reagent in a timely manner and evaluating the calibration status of the detection reagent when the control software, the sample analyzer, and the detection reagent are newly enabled or re-enabled is conducive to promptly discovering whether the detection reagent loaded on the sample analyzer needs to be calibrated, promptly generating a corresponding calibration task, preparing for subsequent detection and analysis of the sample to be tested, facilitating the normal progress of the detection and analysis of the sample analyzer, and improving the accuracy of the detection and analysis results. Among them, the control software may include software for controlling the sample analyzer, which may be system software or application software, and is not limited herein.

[0044] In one embodiment, the calibration information may include the calibration curve of the detection reagent and the validity period of the calibration curve. Evaluating the calibration status of the detection reagent according to the calibration information may include: when the calibration information includes a calibration curve and the validity period of the calibration curve is greater than 0 and does not exceed a preset duration, evaluating the calibration status of the detection reagent as about to expire; when the calibration information includes a calibration curve and the validity period of the calibration curve does not exceed 0, or when the calibration information does not include a calibration curve, evaluating the calibration status of the detection reagent as invalid; the preset status may include at least one of the following: about to expire and invalid.

[0045] Among them, the preset duration can be set by the user according to needs. For example, it can be 2 days, 10 days, etc., and the present application does not make specific limitations thereon.

[0046] In this embodiment, when the validity period of the calibration curve is greater than 0 and less than the preset duration, it indicates that the validity period of the calibration curve is short, so the calibration status of the detection reagent can be evaluated as about to expire; when the validity period of the calibration curve is less than or equal to 0, it indicates that the calibration curve has expired, so the calibration status of the detection reagent can be evaluated as invalid.

[0047] In other embodiments, the calibration status of the detection reagent can also be evaluated in other ways. For example, the calibration status of the detection reagent can be evaluated according to the batch code of the detection reagent, and certain specific batches of detection reagents can be evaluated as valid or invalid. The present application does not limit this.

[0048] In one embodiment, for the target detection reagent whose calibration status meets the preset status, generating the calibration task of the target detection reagent by the control device of the sample analyzer may include: when the calibration status is invalid, generating a first calibration task for the target detection reagent by the control device of the sample analyzer; and / or when the calibration status is about to expire, generating a second calibration task for the target detection reagent by the control device of the sample analyzer.

[0049] In this embodiment, a first calibration task is generated for the invalid detection reagent. The first calibration task indicates that the detection reagent needs to be calibrated immediately, otherwise the detection results using this detection reagent are inaccurate. In one embodiment, when generating the first calibration task, the available status of the detection reagents with the same identification information as the target detection reagent corresponding to the first calibration task can be set to the disabled status. A second calibration task is generated for the detection reagent about to expire. The second calibration task indicates that the detection reagent is currently still available, but needs to be calibrated within a certain period of time, otherwise it will become unavailable after this time.

[0050] Briefly speaking, the priority of the first calibration task is higher than that of the second calibration task. Therefore, when arranging the order of calibration tasks, the execution of the first calibration task is considered first to make the disabled detection reagent available. After all the executable first calibration tasks are completed, the second calibration task is executed to extend the calibration curve about to expire.

[0051] In this embodiment, different calibration tasks are generated for different calibration statuses of the target detection reagent, which is beneficial to reasonably arranging the calibration order of the target detection reagent according to the different degrees of calibration urgency, and is beneficial to the orderly progress of sample detection by the sample analyzer.

[0052] In specific operations, when the sample analyzer is in the idle time, for example, after completing the daily startup routine maintenance program, or when the sample analyzer does not receive a new detection task, the sample analyzer automatically switches to the calibration program to automatically execute the uncompleted calibration tasks.

[0053] Continue to refer to Figure 1 , in one embodiment, after generating the second calibration task, monitor the remaining validity period of the target detection reagent. When the remaining validity period is equal to 0, switch the second calibration task of the target detection reagent to the first calibration task.

[0054] In this embodiment, for a detection reagent whose calibration curve is about to expire, after generating the second calibration task, the remaining validity period of the detection reagent can continue to be monitored. When the remaining validity period of the calibration curve is equal to 0, the second calibration task is timely changed to the first calibration task to increase the urgency of the calibration task.

[0055] In one embodiment, the method may further include: based on the first calibration task and / or the second calibration task to be executed, retrieving in the database the standard sample loaded in the sample bin and its position information corresponding to the first calibration task and / or the second calibration task; calling the standard sample according to the position information of the standard sample, and executing the corresponding first calibration task and / or the second calibration task to generate calibration information of the target detection reagent corresponding to the first calibration task and / or the second calibration task.

[0056] In this embodiment, the sample bin may be the sample bin of the sample manager or the sample bin of the sample analyzer. In the case where one control device controls multiple sample analyzers, multiple sample analyzers may share the sample bin of one sample manager, or each sample analyzer may have its own sample bin.

[0057] For example, based on the target detection reagent corresponding to the first calibration task, the standard sample loaded in the sample bin and its position information corresponding to the target detection reagent can be retrieved in the database. Then, according to the position information of the standard sample, the first calibration task is executed, and calibration information of the target detection reagent is generated, such as a calibration curve and the validity period of the calibration curve. The second calibration task can be executed in the same way, which will not be elaborated here.

[0058] In this embodiment, by retrieving the position information of the standard sample in the database, the automatic execution of the calibration task is realized, the trouble of manual operation is eliminated, and the detection efficiency is improved.

[0059] In one embodiment, the position information of the newly loaded standard sample in the sample bin is obtained through a tag reading device, and the position information of the newly loaded standard sample is associated and stored in the database with the corresponding standard sample.

[0060] In this embodiment, the tag reading device and the identification reading device may be the same device, or two devices, and may be the same device or different devices.

[0061] In one embodiment, the calibration method of the present invention can be executed according to a preset period. The preset period may be, for example, 1 day, 3 days, 10 days, 15 days, etc., and the present application is not limited thereto.

[0062] By regularly performing calibration tasks, the detection reagent can be calibrated in a timely manner, which is conducive to the smooth and efficient progress of sample detection.

[0063] Reference Figure 2 , in one embodiment, when the first calibration task and the second calibration task are generated simultaneously, the display device can be controlled to display the first calibration task and the second calibration task simultaneously, and the first calibration task can be displayed before the second calibration task to reflect that the urgency of the first calibration task is greater than that of the second calibration task. In Figure 2 , the content displayed by the display device includes information such as the project name, reagent batch number, calibration reason, calibration (sample) batch number, and module name. In other embodiments, more or less information may also be displayed, and the present application does not make specific limitations in this regard. Figure 3 It is a schematic diagram of a control for executing a calibration task on a calibration task display interface. Figure 3 The control shown is only an example, and the control can also be in other forms.

[0064] This embodiment provides a calibration device, including: a state evaluation module for evaluating the calibration state of the detection reagent; a task generation module for generating a calibration task for the target detection reagent by the control device of the sample analyzer when the calibration state meets a preset state.

[0065] The calibration device of this embodiment may further include a processor and a memory. The processor is used to execute the above-mentioned various program modules stored in the memory to automatically generate a calibration task for the target detection reagent in a timely manner.

[0066] This embodiment provides a computing device, including a processor and a memory. A computer program is stored in the memory, and when the computer program is executed by the processor, the steps of the above-mentioned calibration method are implemented.

[0067] In one embodiment, the computing device may include one or more processors (CPUs), an input / output interface, a network interface, and a memory.

[0068] The memory may include non-permanent memory in a computer-readable medium, random access memory (RAM), and / or non-volatile memory in the form of read-only memory (ROM) or flash memory (FLASH RAM). The memory is an example of a computer-readable medium.

[0069] This embodiment provides a computer-readable storage medium, in which a computer program is stored. When the computer program is executed by the processor, the steps of the above-mentioned calibration method are implemented.

[0070] A computer program can be embodied in any combination of one or more storage media. The storage media can be a readable signal medium or a readable storage medium.

[0071] The readable storage medium can, for example, include an electrical, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or any combination of the foregoing. More specific examples (a non-exhaustive list) of the readable storage medium can include: an electrical connection with one or more wires, a portable disk, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or Flash memory), an optical fiber, a portable compact disk read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the foregoing.

[0072] The readable signal medium can include a data signal propagated in a baseband or as part of a carrier wave, in which a readable computer program is carried. Such a propagated data signal can take many forms, for example, it can include an electromagnetic signal, an optical signal, or any suitable combination of the foregoing. The readable signal medium can also be any storage medium other than the readable storage medium, which can send, propagate, or transmit a program for use by or in connection with an instruction execution system, apparatus, or device.

[0073] The computer program contained on the storage medium can be transmitted by any appropriate medium, for example, it can include wireless, wire, optical fiber, RF, etc., or any suitable combination of the foregoing.

[0074] The computer program for performing the operations of the present invention can be written in any combination of one or more programming languages. The programming languages can include object-oriented programming languages, such as Java, C++, etc., and can also include conventional procedural programming languages, such as the "C" language or similar programming languages. The computer program can be executed entirely on the user's computing device, partially on the user's device, or entirely on a remote computing device or server. In the case of a remote computing device, the remote computing device can be connected to the user's computing device through any type of network (for example, it can include a local area network or a wide area network), or can be connected to an external computing device (for example, by using an Internet service provider to connect through the Internet).

[0075] This embodiment provides a sample analysis system, which can include: the above-mentioned computing device and at least one sample analyzer. Among them, the sample analyzer is used to perform a calibration task according to the control instruction of the computing device to calibrate the target detection reagent to be calibrated.

[0076] Reference Figure 4, in one embodiment, the sample analysis system may consist of a host computer, a sample manager, and four sample analyzers. The host computer can communicate with the sample manager and each sample analyzer separately, and control the sample manager and each sample analyzer separately so that each sample analyzer performs the calibration task generated by the host computer.

[0077] Among them, standard samples can be loaded in the sample bin of the sample manager. The standard samples in the sample manager can be distributed to the target sample analyzer among multiple sample analyzers through devices such as tracks, chutes, and conveyor belts, and the target sample analyzer performs the calibration task.

[0078] It should be noted that the terms used herein are only for describing specific embodiments and are not intended to limit the exemplary embodiments according to the present application. When the terms "comprising" and / or "including" are used in this specification, they indicate the presence of features, steps, operations, devices, components, and / or combinations thereof.

[0079] It should be noted that the terms "first", "second", etc. in the specification, claims, and drawings of the present application are used to distinguish similar objects and are not used to describe a specific order or sequence. It should be understood that such terms can be interchanged under appropriate circumstances.

[0080] It should be understood that the exemplary embodiments in this specification can be implemented in many different forms and should not be construed as being limited only to the embodiments set forth herein. Additionally or alternatively, certain steps may be omitted, multiple steps may be combined into one step for execution, and / or one step may be decomposed into multiple steps for execution. These embodiments are provided to make the disclosure of the present application thorough and complete, and to fully convey the concept of these exemplary embodiments to those of ordinary skill in the art, and should not be construed as a limitation of the present invention.

[0081] Although the spirit and principles of the present invention have been described with reference to several specific embodiments, it should be understood that the present invention is not limited to the specific embodiments disclosed, and the division of each aspect does not mean that the features in these aspects cannot be combined for benefit. This division is only for the convenience of expression. The present invention aims to cover various modifications and equivalent arrangements included within the spirit and scope of the appended claims.

Claims

1. A calibration method for a sample analyzer that uses a detection reagent to detect the concentration of a specific substance in a blood sample, characterized in that, Including: Obtain the calibration information of the detection reagent loaded in the reagent magazine of the sample analyzer, and evaluate the calibration status of the detection reagent according to the calibration information; For the target detection reagent whose calibration status meets the preset status, the control device of the sample analyzer generates a calibration task for the target detection reagent.

2. The calibration method according to claim 1, wherein It also includes: Obtain the identification information of the detection reagent loaded in the reagent magazine of the sample analyzer through an identification reading device, and / or retrieve the identification information of the detection reagent loaded in the reagent magazine of the sample analyzer from a database; Obtaining the calibration information of the detection reagent loaded in the reagent magazine of the sample analyzer includes: Retrieve the calibration information of the detection reagent loaded in the reagent magazine of the sample analyzer from the database according to the identification information.

3. The calibration method according to claim 2, characterized in that, In the case of a preset trigger event occurring, then retrieve the calibration information of the detection reagent loaded in the reagent magazine of the sample analyzer from the database, where the preset trigger event includes at least one of the following: After receiving the startup signal of the control software, for the first time, obtain the identification information of the detection reagent loaded in the reagent magazine of the sample analyzer; After receiving the power-on signal of the sample analyzer or after receiving the enabling signal for the sample analyzer to switch to the enabled state, for the first time, obtain the identification information of the detection reagent loaded in the reagent magazine of the sample analyzer; Receive the loading signal for a newly loaded detection reagent in the reagent magazine of the sample analyzer; and Receive the enabling signal for the detection reagent in the reagent magazine of the sample analyzer to switch to the enabled state.

4. The calibration method according to claim 1, wherein The calibration information includes the calibration curve of the detection reagent and the validity period of the calibration curve; Evaluating the calibration status of the detection reagent according to the calibration information includes: In the case where the calibration information includes a calibration curve, and the validity period of the calibration curve is greater than 0 and does not exceed a preset duration, evaluate the calibration status of the detection reagent as about to expire; In the case where the calibration information includes a calibration curve and the validity period of the calibration curve does not exceed 0, or in the case where the calibration information does not include a calibration curve, evaluate the calibration status of the detection reagent as invalid; The preset status includes at least one of the following: about to expire and invalid.

5. The calibration method according to claim 4, wherein For the target detection reagent whose calibration status meets the preset status, the control device of the sample analyzer generates a calibration task for the target detection reagent, including: In the case where the calibration status is invalid, the control device of the sample analyzer generates a first calibration task for the target detection reagent; and / or In the case where the calibration status is about to expire, the control device of the sample analyzer generates a second calibration task for the target detection reagent.

6. The calibration method according to claim 5, characterized in that, It also includes: After generating the second calibration task, monitor the remaining validity period of the target detection reagent. When the remaining validity period is equal to 0, switch the second calibration task of the target detection reagent to the first calibration task.

7. The calibration method according to claim 5 or 6, characterized in that, It also includes: When generating the first calibration task, set the available status of the detection reagents with the same identification information as the target detection reagent corresponding to the first calibration task to the disabled state.

8. The calibration method according to claim 5 or 6, characterized in that It also includes: Retrieve the standard samples loaded in the sample bin and their location information corresponding to the first calibration task and / or the second calibration task to be executed in the database; Call the standard samples according to the location information of the standard samples, execute the corresponding first calibration task and / or the second calibration task, and generate calibration information of the target detection reagent corresponding to the first calibration task and / or the second calibration task.

9. The calibration method according to claim 8, wherein Obtain the location information of the newly loaded standard samples in the sample bin through a tag reading device, and store the location information of the newly loaded standard samples in association with the corresponding standard samples in the database.

10. A sample analysis system, characterized in that, Comprising: A computing device, including a processor and a memory, wherein a computer program is stored in the memory, and when the computer program is executed by the processor, the steps of the calibration method according to any one of claims 1 to 9 are implemented; At least one sample analyzer for executing a calibration task according to a control instruction of the computing device.

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