Sample detection device and sample detection method

Abstract

The invention discloses a sample detection device and a sample detection method. The sample detection device comprises a reagent module; the reaction module is connected with the reagent module through a reagent conveying pipeline, and the reagent module is used for conveying a reagent to the reaction module; the processing module is used for responding to a received sample detection instruction and determining whether the reaction module is subjected to over-cleaning in a target time period or not; the target time period is a time period from the moment when the reagent module finishes conveying the reagent last time to the current moment; in response to the fact that the reaction module is cleaned in the target time period, liquid in the reagent conveying pipeline is abandoned, and then the reagent module is controlled to convey a reagent to the reaction module, so that the reaction module is used for preparing sample liquid based on the reagent and carrying out sample detection. Based on the mode, the use cost of the reagent can be reduced.

Description

Technical Field

[0001] This application relates to the field of detection technology, and in particular to a sample detection device and a sample detection method. Background Art

[0002] In the prior art, a reagent module and a reaction module are provided in a sample analyzer. The reagent module can be connected to the reagent module through a corresponding reagent delivery pipeline. The reagent module is used to deliver a reagent to the reaction module through the reagent delivery pipeline when sample detection is required, so as to prepare a sample solution for sample detection.

[0003] The defect of the prior art is that after the reagent module delivers the reagent to the reaction module, some reagent will remain in the reagent delivery pipeline. Therefore, after the reaction module is cleaned, the reagent remaining in the reagent delivery pipeline connected to the reaction module is easily diluted or contaminated. To avoid the influence of the cleaning solution diluted or contaminated on the reaction channel, usually the liquid in the reagent delivery pipeline is discarded after cleaning, so that even if the reagent module with a low usage frequency does not deliver the reagent for sample detection, the reagent will be seriously wasted due to the above-mentioned discarded operation after cleaning, resulting in a high usage cost of the reagent. Summary of the Invention

[0004] The main technical problem to be solved by this application is how to reduce the usage cost of the reagent.

[0005] To solve the above technical problem, the first technical solution adopted by this application is: a sample detection device, including: a reagent module; a reaction module, the reaction module is connected to the reagent module through a reagent delivery pipeline, and the reagent module is used to deliver a reagent to the reaction module; a processing module, the processing module is used to: in response to receiving a sample detection instruction, determine whether the reaction module has been cleaned within a target period; wherein, the target period is the period between the moment when the reagent module last delivered the reagent and the current moment; in response to the reaction module having been cleaned within the target period, discard the liquid in the reagent delivery pipeline, and then control the reagent module to deliver the reagent to the reaction module, so that the reaction module is used to prepare a sample solution based on the reagent for sample detection.

[0006] Wherein, the processing module is further used to: in response to the reaction module not having been cleaned within the target period, control the reagent module to deliver the reagent to the reaction module, so that the reaction module is used to prepare a sample solution based on the reagent for sample detection.

[0007] Among them, the reaction module is the module that needs to be used as indicated by the sample detection instruction; in response to receiving the sample detection instruction, it is determined whether the reaction module has been cleaned within the target period, including: in response to receiving the sample detection instruction and the reaction module being an infrequently used reaction module, it is determined whether the duration of the target period is greater than the preset duration; among them, the infrequently used reaction module is a reaction module with a usage frequency less than the preset usage frequency threshold; in response to the duration of the target period not being greater than the preset duration, it is determined whether the reaction module has been cleaned within the target period; the processing module is further configured to: in response to the duration of the target period being greater than the preset duration, discard the liquid in the reagent delivery pipeline, and then control the reagent module to deliver reagents to the reaction module, so that the reaction module is used to prepare a sample solution based on the reagents for sample detection.

[0008] Among them, in response to receiving the sample detection instruction, it is determined whether the reaction module has been cleaned within the target period, including: in response to receiving the sample detection instruction and the reaction module being a frequently used reaction module, it is determined whether the reaction module has been cleaned within the target period.

[0009] Among them, in response to the reaction module having been cleaned within the target period, the liquid in the reagent delivery pipeline is discarded, and then the reagent module is controlled to deliver reagents to the reaction module, so that the reaction module is used to prepare a sample solution based on the reagents for sample detection, including: in response to the reaction module having been cleaned within the target period, the cleaning degree of the cleaning is determined; in response to the cleaning degree being greater than the preset cleaning degree threshold, the liquid in the reagent delivery pipeline is discarded, and then the reagent module is controlled to deliver reagents to the reaction module, so that the reaction module is used to prepare a sample solution based on the reagents for sample detection.

[0010] Among them, the processing module is further configured to: in response to the cleaning degree not being greater than the preset cleaning degree threshold, control the reagent module to deliver reagents to the reaction module, so that the reaction module is used to prepare a sample solution based on the reagents for sample detection.

[0011] Among them, the cleaning degree is positively correlated with the cleaning intensity of the cleaning liquid used in the cleaning, and / or the cleaning degree is positively correlated with the number of cleaning times.

[0012] Among them, the sample detection device further includes: an in-machine cleaning liquid module for storing cleaning liquid; an out-of-machine cleaning liquid module for storing cleaning liquid; the processing module is further configured to: obtain a user's cleaning liquid selection instruction; in response to the cleaning liquid module indicated by the cleaning liquid selection instruction being the in-machine cleaning liquid module, when cleaning the sample detection device, control the in-machine cleaning liquid module to transport the cleaning liquid to the modules and liquid paths that need to be cleaned inside the sample detection device for cleaning; in response to the cleaning liquid module indicated by the cleaning liquid selection instruction being the out-of-machine cleaning liquid module, when cleaning the sample detection device, control the out-of-machine cleaning liquid module to transport the cleaning liquid to the modules and liquid paths that need to be cleaned inside the sample detection device for cleaning.

[0013] Among them, the sample detection device further includes an in-machine cleaning liquid module and / or an out-of-machine cleaning liquid module; the in-machine cleaning liquid module is used for storing cleaning liquid; the out-of-machine cleaning liquid module is used for storing cleaning liquid; the processing module is further configured to: in response to the sample detection device being provided with an in-machine cleaning liquid module and an out-of-machine cleaning liquid module, control the in-machine cleaning liquid module to transport the cleaning liquid to the modules and liquid paths that need to be cleaned inside the sample detection device for cleaning; and / or, in response to the sample detection device being provided with an in-machine cleaning liquid module, control the in-machine cleaning liquid module to transport the cleaning liquid to the modules and liquid paths that need to be cleaned inside the sample detection device for cleaning; and / or, in response to the sample detection device being provided with an out-of-machine cleaning liquid module, control the out-of-machine cleaning liquid module to transport the cleaning liquid to the modules and liquid paths that need to be cleaned inside the sample detection device for cleaning.

[0014] To solve the above technical problem, the second technical solution adopted in this application is: a sample detection method applied to the above sample detection device; the sample detection method includes: in response to receiving a sample detection instruction, determining whether the reaction module has been cleaned within a target period; where the target period is the period between the moment when the reagent module last finished transporting the reagent and the current moment; in response to the reaction module having been cleaned within the target period, discarding the liquid in the reagent delivery pipeline, and then controlling the reagent module to transport the reagent to the reaction module, so that the reaction module is used to prepare a sample solution based on the reagent for sample detection.

[0015] The beneficial effects of the present application are as follows: Different from the prior art, in the technical solution of the present application, the reagent module can be connected to the reaction module through corresponding reagent delivery pipelines. The reagent module is used to deliver reagents to the reaction module through the reagent delivery pipelines. The processing module is used to determine whether the reaction module has been cleaned during the period from the moment when the reagent module last finished delivering reagents to the current moment when receiving a sample detection instruction. If it has been cleaned, the liquid in the reagent delivery pipelines is discarded. Based on the above method, every time a sample needs to be detected, the liquid in the reagent delivery pipelines that have been cleaned for the reaction module during the target period can be discarded, reducing the possibility of discarding the liquid in the reagent delivery pipelines after each cleaning, maximizing the utilization rate of reagents, reducing reagent waste, and thus reducing the usage cost of reagents. Brief Description of the Drawings

[0016] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following will briefly introduce the drawings required for description in the embodiments. Obviously, the following drawings are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on these drawings.

[0017] Figure 1 It is a schematic structural diagram of an embodiment of the sample detection device of the present application;

[0018] Figure 2 It is a schematic flowchart of an embodiment of the sample detection method of the present application.

[0019] Reference Numerals: Reagent Module 11, Reaction Module 12, Reagent Delivery Pipeline 13. Detailed Description of the Embodiments

[0020] The following will further describe the present application in detail in conjunction with the drawings and embodiments. It should be specifically noted that the following embodiments are only used to illustrate the present application, but do not limit the scope of the present application. Similarly, the following embodiments are only partial embodiments of the present application rather than all embodiments. All other embodiments obtained by those of ordinary skill in the art without creative efforts fall within the scope of protection of the present application.

[0021] Referring to "embodiments" herein means that specific features, structures, or characteristics described in conjunction with the embodiments may be included in at least one embodiment of the present application. The phrase appears in various positions in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment mutually exclusive with other embodiments. Those skilled in the art will explicitly and implicitly understand that the embodiments described herein can be combined with other embodiments.

[0022] In the description of the present application, it should be noted that unless otherwise clearly specified and defined, the terms "install", "set", "connect", and "couple" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium. For those of ordinary skill in the art, the specific meanings of the above terms in the present application can be determined according to specific circumstances.

[0023] The present application first proposes a sample detection device. Refer to Figure 1 , Figure 1 which is a schematic structural diagram of an embodiment of the sample detection device of the present application. As Figure 1 shown, the sample detection device includes a reagent module 11, a reaction module 12, and a processing module (not shown in the figure).

[0024] The reaction module 12 is connected to the reagent module 11 through a reagent delivery pipeline 13, and the reagent module 11 is used to deliver reagents to the reaction module 12.

[0025] Specifically, the reagent module 11 may include a suction / discharge unit and a reagent unit. The suction / discharge unit can be respectively connected to the reagent unit and one end of the reagent delivery pipeline. The other end of the reagent delivery pipeline is connected to the reaction module. The reagent unit is used to store reagents, and the reagents can specifically be staining solutions or other types of reagents, which are not limited herein.

[0026] The suction / discharge unit can first connect to the reagent unit, suck in the reagent, and then connect to the reagent delivery pipeline 13 to discharge the reagent, so that the reagent is delivered to the reaction module 12 to achieve the delivery of the reagent.

[0027] The processing module is used for:

[0028] In response to receiving a sample detection instruction, determine whether the reaction module 12 has been cleaned within a target time period.

[0029] Wherein, the target time period is the time period between the moment when the reagent module 11 last finished delivering the reagent and the current moment.

[0030] The sample detection instruction can specifically be an instruction generated by a user operating the sample detection device, or an instruction generated in other ways, which are not limited herein.

[0031] After receiving the sample detection instruction, the processing module can determine that a sample detection needs to be performed at this time, so it is necessary to detect and determine whether the reaction module 12 has been cleaned within the target time period.

[0032] If the reaction module 12 has not been cleaned within the target period, the likelihood that the reagent in the reagent delivery line 13 is diluted or contaminated is relatively low. The reagent module 11 can be directly controlled to deliver the reagent to the reaction module 12 to prepare a sample solution for sample detection.

[0033] If the reaction module 12 has been cleaned within the target period, the likelihood that the reagent in the reagent delivery line 13 is diluted or contaminated is relatively high. The processing module can perform subsequent steps in response to the reaction module 12 having been cleaned within the target period.

[0034] In response to the reaction module 12 having been cleaned within the target period, the liquid in the reagent delivery line 13 is discarded, and then the reagent module 11 is controlled to deliver the reagent to the reaction module 12 so that the reaction module 12 can be used to prepare a sample solution based on the reagent for sample detection.

[0035] Among them, on the premise that it is determined that the reaction module 12 has been cleaned within the target period, within the period from the moment when the reagent module 11 last finished delivering the reagent to the current moment, the reaction module 12 may have been cleaned once or more than twice. The more times of cleaning, the higher the likelihood that the reagent in the reagent delivery line 13 is diluted or contaminated.

[0036] If the reaction module 12 has been cleaned once or more than twice within the target period, it can be determined that the likelihood that the reagent in the reagent delivery line 13 is diluted or contaminated is relatively high. At this time, the processing module can discard the liquid in the reagent delivery line.

[0037] For example, the processing module can control the reagent module 11 to push the liquid in the reagent delivery line into the reaction module 12, and the reaction module 12 then discharges the discarded liquid into the corresponding connected waste liquid module (not shown in the figure) to complete the discarding of the liquid.

[0038] Based on the above method, the likelihood of having to discard the liquid in the reagent delivery line 13 after each cleaning can be reduced. If the number of times the reaction module 12 is cleaned within the target period is more than twice, the technical solution of the present application can reduce the number of times of discarding the reagent and thus reduce the amount of discarded reagent compared with the traditional technology.

[0039] On this basis, especially for some reagent modules with relatively low usage frequencies but high costs of the transported reagents, there may be multiple cleanings of the reaction module 12 during the interval between two uses. However, it is only necessary to determine whether reagent discard is required when it is necessary to use the reagent module with a relatively low usage frequency to transport reagents for sample detection. Only when the reaction module 12 has been cleaned during the target period, the liquid in the reagent delivery pipeline 13 is discarded. Compared with the conventional technology that discards the liquid in the reagent delivery pipeline 13 after each cleaning, the technical solution of the present application reduces reagent waste, improves the utilization rate of reagents, and reduces the usage cost of reagents.

[0040] Different from the prior art, in the technical solution of the present application, the reagent module can be connected to the reaction module through a corresponding reagent delivery pipeline. The reagent module is used to transport reagents to the reaction module through the reagent delivery pipeline. The processing module is used to determine whether the reaction module has been cleaned during the period from the moment when the reagent module last transported the reagent to the current moment when receiving a sample detection instruction. If it has been cleaned, the liquid in the reagent delivery pipeline is discarded. Based on the above method, when each sample detection is required, the liquid in the reagent delivery pipeline of the reaction module that has been cleaned during the target period can be discarded, reducing the possibility of discarding the liquid in the reagent delivery pipeline after each cleaning, maximizing the utilization rate of reagents, reducing reagent waste, and thus reducing the usage cost of reagents.

[0041] In one embodiment, the processing module is further configured to:

[0042] In response to the reaction module 12 not being cleaned during the target period, control the reagent module 11 to transport the reagent to the reaction module 12, so that the reaction module 12 is used to prepare a sample solution based on the reagent for sample detection.

[0043] Specifically, if the reaction module 12 has not been cleaned during the target period, the possibility of the reagent in the reagent delivery pipeline 13 being diluted or contaminated is relatively low. The reagent module 11 can be directly controlled to transport the reagent to the reaction module 12 to prepare a sample solution for sample detection.

[0044] Based on the above method, when it is determined that the reaction module 12 has not been cleaned during the target period, since the possibility of the reagent in the reagent delivery pipeline 13 being diluted and contaminated is relatively low, the liquid in the reagent delivery pipeline 13 does not need to be discarded. Instead, the reagent module 11 can be directly controlled to transport the reagent to the reaction module 12, which can not only reduce reagent waste but also improve the overall efficiency of sample detection and the reliability of the sample detection device.

[0045] In one embodiment, the reaction module 12 is the module required to be used as indicated by the sample detection instruction.

[0046] In response to receiving the sample detection instruction, it is determined whether the reaction module 12 has been cleaned within the target period, including:

[0047] In response to receiving the sample detection instruction and the reaction module 12 being an infrequently used reaction module, it is determined whether the duration of the target period is greater than the preset duration. Herein, the infrequently used reaction module is the reaction module 12 with a usage frequency less than the preset usage frequency threshold.

[0048] In response to the duration of the target period being not greater than the preset duration, it is determined whether the reaction module 12 has been cleaned within the target period.

[0049] The processing module is further configured to:

[0050] In response to the duration of the target period being greater than the preset duration, the liquid in the reagent delivery pipeline 13 is discarded, and then the reagent module 11 is controlled to deliver a reagent to the reaction module 12, so that the reaction module 12 is used to prepare a sample solution based on the reagent for sample detection.

[0051] Specifically, the infrequently used reaction module is the reaction module 12 with a usage frequency less than the preset usage frequency threshold. The frequently used reaction module is the reaction module 12 with a usage frequency not less than the preset usage frequency threshold.

[0052] In one example, the sample detection device may include multiple reagent modules 11, such as the reagent module 11 required for DIFF channel detection, the reagent module 11 required for WNR channel detection, the reagent module 11 required for RET channel detection, the reagent module 11 required for WPC channel detection, and the reagent module 11 required for other channel detections, which are not limited herein.

[0053] Among them, the reagent module 11 required for DIFF channel detection and the reagent module 11 required for WNR channel detection are both reagent modules 11 with a usage frequency not less than the preset usage frequency threshold and a relatively high usage frequency, that is, frequently used reaction modules.

[0054] The reagent module 11 required for RET channel detection and the reagent module 11 required for WPC channel detection are both reagent modules 11 with a usage frequency less than the preset usage frequency threshold and a relatively low usage frequency, that is, infrequently used reaction modules.

[0055] When it is determined that the reaction module 12 is an infrequently used reaction module, since the usage frequency of the infrequently used reaction module is low, the cleaning frequency of the corresponding connected reaction module 12 is usually configured to be low. Therefore, it is necessary to determine whether the duration of the target period is greater than the preset duration at this time. If it is not greater than the preset duration, it is considered that the possibility of the reaction module 12 being cleaned is low, and it is necessary to further determine whether the reaction module 12 has been cleaned, and perform the operation of discarding the liquid when the reaction module 12 has been cleaned.

[0056] If it is greater than the preset duration, then: First, it can be considered that the possibility of the reaction module 12 being cleaned is high, and the operation of discarding the liquid can be directly performed. Or, second, it can also be considered that even if the reagent in the reagent delivery pipeline 13 has not been cleaned, its quality has been affected due to the excessive idle time, such as phenomena like deterioration and deposition, and the liquid in the reagent delivery pipeline 13 is directly discarded.

[0057] Based on the above method, for the infrequently used reaction module, when the duration of its corresponding target period is within different ranges, corresponding processing steps can be supplemented. When the duration of the target period is greater than the preset duration and it is determined that the possibility of the reaction module 12 being cleaned is high, the steps of detecting and determining whether the reaction module 12 has been cleaned are no longer executed, but the liquid in the reagent delivery pipeline 13 is directly discarded, improving the efficiency of sample detection.

[0058] Optionally, in response to receiving a sample detection instruction, determining whether the reaction module 12 has been cleaned within the target period includes:

[0059] In response to receiving a sample detection instruction and the reaction module 12 being a frequently used reaction module, determine whether the reaction module 12 has been cleaned within the target period.

[0060] Specifically, when it is determined that the reaction module 12 is a frequently used reaction module, since the usage frequency of the frequently used reaction module is high, it can be considered that the possibility that the duration of the target period is not greater than the preset duration is high, and it can be directly determined whether the reaction module 12 has been cleaned within the target period. Compared with the infrequently used reaction module, the step of whether the duration of the target period is greater than the preset duration does not need to be executed, reducing the complexity of the steps and improving the efficiency of sample detection.

[0061] In an embodiment, in response to the reaction module 12 being cleaned within the target period, the liquid in the reagent delivery pipeline 13 is discarded, and then the reagent module 11 is controlled to deliver the reagent to the reaction module 12 so that the reaction module 12 is used to prepare a sample solution based on the reagent for sample detection, including:

[0062] In response to the reaction module 12 being cleaned within the target period, determine the degree of cleaning.

[0063] In response to the cleaning degree being greater than a preset cleaning degree threshold, the liquid in the reagent delivery pipeline 13 is discarded, and then the reagent module 11 is controlled to deliver a reagent to the reaction module 12, so that the reaction module 12 is used to prepare a sample solution based on the reagent for sample detection.

[0064] Specifically, when it is determined that the reaction module 12 has been cleaned during the target period, the cleaning degree of the cleaning received by the reaction module 12 during the target period can be further determined.

[0065] When the cleaning degree is greater than the preset cleaning degree threshold, it can be considered that the reagent in the reagent delivery pipeline 13 is highly likely to be diluted or contaminated. Therefore, it is necessary to discard the liquid in the reagent delivery pipeline 13 to reduce the possibility of the sample detection result being distorted due to the possibly diluted or contaminated reagent, thereby improving the reliability of the sample detection device.

[0066] It should be noted that the cleaning degree can be positively correlated with the cleaning intensity of the cleaning liquid used in the cleaning, and / or the cleaning degree is positively correlated with the number of cleaning times.

[0067] Generally speaking, the reaction module 12 is cleaned after the sample detection device is powered on and before it is powered off, and / or the reaction module 12 is cleaned at every preset interval after being powered on. The preset interval can be negatively correlated with the usage frequency of the reagent module 11 connected to the reaction module 12. On this basis, during the target period, the number of times the reaction module 12 may be cleaned can be one, two, five, or other numbers more than two times, which is not limited here. The more times of cleaning during the target period, the higher the determined cleaning degree, and thus the higher the possibility that the reagent in the reagent delivery pipeline 13 is diluted or contaminated.

[0068] In addition, the cleaning intensity of the cleaning liquid is related to the type of the cleaning liquid itself. For example, the cleaning liquid can be a probe liquid, and the probe liquid can specifically be a strong acid or a strong base. The cleaning liquid can also be a diluent. Among them, the cleaning intensity of the probe liquid is greater than that of the diluent. The probe liquid is usually used to clean stubborn stains such as proteins remaining in the reaction module or the liquid path, and is generally used for cleaning coagulated stains during the power-on and power-off of the sample detection device or during regular maintenance with a long interval. The diluent is usually used for cleaning when there is liquid flowing repeatedly in the liquid path when the sample detection device is powered on. On this basis, the higher the cleaning intensity of the cleaning liquid used to clean the reaction module 12 during the target period, the higher the determined cleaning degree, and thus the higher the possibility that the reagent in the reagent delivery pipeline 13 is diluted or contaminated.

[0069] Based on the above method, the influence on the reaction module 12 during the target period due to cleaning can be quantified by the degree of cleaning. And only when the degree of cleaning is greater than the preset cleaning degree threshold, the operation of discarding the liquid is executed, reducing the possibility of wasting reagents, improving the utilization rate of reagents, and reducing the usage cost of reagents.

[0070] Optionally, the processing module is further configured to:

[0071] In response to the degree of cleaning not being greater than the preset cleaning degree threshold, control the reagent module 11 to deliver the reagent to the reaction module 12, so that the reaction module 12 is used to prepare a sample solution based on the reagent for sample detection.

[0072] Specifically, the degree of cleaning may be positively correlated with the cleaning intensity of the cleaning liquid used during cleaning, and / or the degree of cleaning is positively correlated with the number of cleaning times.

[0073] When the degree of cleaning is not greater than the preset cleaning degree threshold, it can be considered that the influence on the cleaning of the reaction module 12 during the target period is small, and the possibility of the reagent in the reagent delivery pipeline being diluted or contaminated is low. The reagent module 11 can be directly controlled to deliver the reagent to the reaction module 12, which can not only reduce the waste of reagents, but also improve the overall efficiency of sample detection and the reliability of the sample detection device.

[0074] In one embodiment, after controlling the reagent module 11 to deliver the reagent to the reaction module 12, the processing module is further configured to:

[0075] In response to the sample injection method being automatic injection or closed injection, control the sample detection device to collect a sample from the automatic injection position or the closed injection position, and deliver the sample to the reaction module 12 to obtain a sample solution for sample detection.

[0076] In response to the sample injection method being open injection and receiving a start detection instruction, control the sample detection device to collect a sample from the open injection position, and deliver the sample to the reaction module 12 to obtain a sample solution for sample detection.

[0077] Specifically, during automatic injection or closed injection, the sample tube containing the sample is usually placed in the corresponding position by the user or the relay component or other components in advance. When open injection is performed, it may be that the user holds the sample tube and places it in the open injection position, and this holding action needs to be maintained during injection. Therefore, it is necessary to start collecting the sample when the user sends a start detection instruction to indicate that they are ready, to avoid the situation where the sample cannot be collected due to an accident, improving the reliability of the sample detection device.

[0078] In one embodiment, the sample detection device further includes:

[0079] The in-machine cleaning liquid module is used to store the cleaning liquid.

[0080] The out-of-machine cleaning liquid module is used to store the cleaning liquid.

[0081] The processing module is further used for:

[0082] Obtaining a user's cleaning liquid selection instruction.

[0083] If the cleaning liquid module indicated by the cleaning liquid selection instruction is the in-machine cleaning liquid module, when cleaning the sample detection device, control the in-machine cleaning liquid module to convey the cleaning liquid to the modules and liquid paths in the sample detection device that need to be cleaned for cleaning.

[0084] If the cleaning liquid module indicated by the cleaning liquid selection instruction is the out-of-machine cleaning liquid module, when cleaning the sample detection device, control the out-of-machine cleaning liquid module to convey the cleaning liquid to the modules and liquid paths in the sample detection device that need to be cleaned for cleaning.

[0085] Specifically, the sample detection device may have a housing with an accommodation space inside. The in-machine cleaning liquid module may be located inside the accommodation space, and the out-of-machine cleaning liquid module may be located outside the accommodation space.

[0086] The user can set the cleaning liquid module used by the sample detection device when cleaning the reaction module 12 or other relevant modules and liquid paths to generate a cleaning liquid selection instruction.

[0087] First, if the cleaning liquid module indicated by the cleaning liquid selection instruction is the in-machine cleaning liquid module, when the sample detection device needs to be cleaned, detect whether there is cleaning liquid in the in-machine cleaning liquid module. If there is no cleaning liquid in the in-machine cleaning liquid module, prompt the user to replace the in-machine cleaning liquid module or supplement the cleaning liquid in the in-machine cleaning liquid module, and return to execute the step of detecting whether there is cleaning liquid in the in-machine cleaning liquid module and subsequent steps. If there is cleaning liquid in the in-machine cleaning liquid module, obtain the target cleaning position, where the target cleaning position is used to describe the modules and / or liquid paths in the sample detection device that need to be cleaned. Control the sampling needle in the sample detection device to extract the cleaning liquid from the in-machine cleaning liquid module and convey the cleaning liquid to the target cleaning position, and / or collect the cleaning liquid from the cleaning liquid module containing the cleaning liquid into the pipeline through the corresponding pipeline for pipeline conveyance to the target cleaning position to achieve cleaning of each position in the target cleaning position and complete the cleaning.

[0088] Second, if the cleaning liquid module indicated by the cleaning liquid selection instruction is an off-board cleaning liquid module, the cleaning liquid test tube containing the cleaning liquid can be placed at the corresponding relay position through any one of automatic sampling, open sampling, and closed sampling. Control the relay component to transport the cleaning liquid test tube to the sampling position, and / or collect the cleaning liquid from the cleaning liquid module containing the cleaning liquid into the pipeline through the corresponding pipeline for pipeline transportation to the corresponding position to be cleaned. Obtain the target cleaning position, which is used to describe the module and / or liquid path to be cleaned in the sample detection device. Control the sampling needle in the sample detection device to extract the cleaning liquid from the cleaning liquid test tube at the sampling position and transport the cleaning liquid to the target cleaning position to achieve the cleaning of each position in the target cleaning position. Control the relay component to send the cleaning liquid test tube to the corresponding test tube rack or other types of areas to be taken, to unload the test tube or allow the user to take it away, and complete the cleaning. Among them, the cleaning liquid test tube is the off-board cleaning liquid module, or the cleaning liquid in the cleaning liquid test tube comes from the off-board cleaning liquid module.

[0089] Based on the above method, the sample detection device can extract the corresponding cleaning liquid when the cleaning liquid module is an in-board cleaning liquid module or an off-board cleaning liquid module, so as to realize the cleaning of the module and / or pipeline. Specifically, it can be determined according to the cleaning liquid selection instruction set by the user, which is not limited here, improving the reliability of the sample detection device.

[0090] In addition, after the cleaning is completed, if the cleaning is triggered before the sample detection device shuts down, control the sample detection device to shut down. If the cleaning is other types of cleaning triggered by the sample detection device, such as cleaning at every preset interval, control the sample detection device to enter the detection preparation state. For example, if a sample detection instruction is received in the detection preparation state, the steps and subsequent steps described in the previous embodiment of determining whether the reaction module 12 has been cleaned within the target time period in response to receiving the sample detection instruction can be returned and executed, which will not be elaborated here.

[0091] In one embodiment, the sample detection device further includes an in-board cleaning liquid module and / or an off-board cleaning liquid module.

[0092] The in-board cleaning liquid module is used to store the cleaning liquid.

[0093] The off-board cleaning liquid module is used to store the cleaning liquid.

[0094] The processing module is further used for:

[0095] In response to the sample detection device being provided with an in-board cleaning liquid module and an off-board cleaning liquid module, control the in-board cleaning liquid module to transport the cleaning liquid to the modules and liquid paths in the sample detection device that need to be cleaned for cleaning.

[0096] And / or,

[0097] In response to the sample detection device being provided with an in-machine cleaning liquid module, the in-machine cleaning liquid module is controlled to deliver cleaning liquid to the modules and liquid paths in the sample detection device that need to be cleaned for cleaning.

[0098] and / or,

[0099] In response to the sample detection device being provided with an external cleaning liquid module, the external cleaning liquid module is controlled to deliver cleaning liquid to the modules and liquid paths in the sample detection device that need to be cleaned for cleaning.

[0100] Specifically, when only the internal cleaning liquid module is provided in the sample detection device, if the sample detection device needs to be cleaned, the cleaning liquid is extracted from the internal cleaning liquid module.

[0101] When only the external cleaning liquid module is provided in the sample detection device, if the sample detection device needs to be cleaned, the cleaning liquid is extracted from the external cleaning liquid module.

[0102] When both an internal cleaning liquid module and an external cleaning liquid module are provided in the sample detection device, if the sample detection device needs to be cleaned, the cleaning liquid is preferentially extracted from the internal cleaning liquid module.

[0103] Based on the above method, when both the in-machine cleaning liquid module and the external cleaning liquid module exist at the same time, the cleaning liquid of the in-machine cleaning liquid module can be used for cleaning first, thereby avoiding as much as possible the situation where the user needs to manually take the external cleaning liquid module for sampling to extract the cleaning liquid, thereby improving convenience and user experience.

[0104] The present application also proposes a sample detection method, which is applied to the sample detection device described in any of the above embodiments, and will not be described in detail here.

[0105] See also Figure 2 , Figure 2 : is a flow chart of an embodiment of the sample detection method of the present application. Figure 2 As shown, the sample detection method includes:

[0106] Step S11: In response to receiving the sample detection instruction, determine whether the reaction module 12 has been cleaned within the target time period. The target time period is the time period from the moment when the reagent module 11 last delivered the reagent to the current moment.

[0107] Step S12: In response to the reaction module 12 being cleaned within the target period, the liquid in the reagent delivery pipeline 13 is discarded, and the reagent module 11 is controlled to deliver the reagent to the reaction module 12, so that the reaction module 12 is used to prepare the sample liquid based on the reagent for sample detection.

[0108] Specifically, the sample detection method may further include the steps performed by the processing module described in any of the foregoing embodiments, which will not be elaborated herein.

[0109] The sample detection device may specifically be a blood analyzer, a sample analyzer, or other types of devices with sample detection capabilities, which are not limited herein.

[0110] Different from the prior art, in the technical solution of the present application, the reagent module can be connected to the reaction module through a corresponding reagent delivery pipeline. The reagent module is used to deliver reagents to the reaction module through the reagent delivery pipeline. The processing module is configured to determine whether the reaction module has been cleaned during the period from the moment when the reagent module last finished delivering reagents to the current moment when receiving a sample detection instruction. If it has been cleaned, the liquid in the reagent delivery pipeline is discarded. Based on the above method, each time a sample needs to be detected, the liquid in the reagent delivery pipeline of the reaction module that has been cleaned during the target period can be discarded, reducing the possibility of discarding the liquid in the reagent delivery pipeline after each cleaning, maximizing the utilization rate of the reagent, reducing the waste of the reagent, and thus reducing the usage cost of the reagent.

[0111] In the description of the present application, the descriptions with reference to terms such as "one embodiment", "some embodiments", "example", "specific example", or "some examples" mean that the specific features, structures, materials, or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present application. In this specification, the schematic descriptions of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described can be combined in a suitable manner in any one or more embodiments or examples. In addition, without contradiction, those skilled in the art can combine and combine the different embodiments or examples described in this specification and the features of different embodiments or examples.

[0112] In addition, the terms "first" and "second" are only used for descriptive purposes and cannot be construed as indicating or implying relative importance or implicitly indicating the quantity of the indicated technical features. Thus, the features defined with "first" and "second" may explicitly or implicitly include at least one of such features. In the description of the present application, "a plurality of" means at least two, such as two, three, etc., unless otherwise specifically defined.

[0113] Any process or method description represented in a flowchart or otherwise described herein can be understood to represent a module, segment, or portion of code including one or more executable instructions for implementing a specific logical function or process. The scope of the preferred embodiments of the present application includes additional implementations where functions may be executed not in the order shown or discussed, including in a substantially simultaneous manner according to the involved functions or in a reverse order, which should be understood by those skilled in the art to which the embodiments of the present application pertain.

[0114] The logic and / or steps represented in a flowchart or otherwise described herein, for example, can be considered a sequenced list of executable instructions for implementing a logical function, and can be embodied specifically in any computer-readable medium for use by or in connection with an instruction execution system, apparatus, or device (which can be a personal computer, server, network device, or other system that can fetch and execute instructions from the instruction execution system, apparatus, or device). For the purposes of this specification, a "computer-readable medium" can be any device that can contain, store, communicate, propagate, or transport a program for use by or in connection with an instruction execution system, apparatus, or device. More specific examples (non-exhaustive list) of the computer-readable medium include the following: an electrical connection portion having one or more wirings (electronic device), a portable computer diskette (magnetic device), a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber device, and a portable compact disc read-only memory (CDROM). Additionally, the computer-readable medium can even be paper or other suitable medium on which the program can be printed, as the program can be obtained electronically, for example, by optically scanning the paper or other medium, followed by editing, interpretation, or other appropriate processing as necessary, and then stored in a computer memory.

[0115] The above is only the embodiment of the present application, and does not limit the patent scope of the present application. Any equivalent structure or equivalent process transformation made by using the specification and drawings of the present application, or directly or indirectly applied in other related technical fields, shall be equally included in the patent protection scope of the present application.

Claims

1. A sample detection device, characterized in that, Comprising: A reagent module; A reaction module, wherein the reaction module is connected to the reagent module through a reagent delivery pipeline, and the reagent module is used to deliver reagents to the reaction module; A processing module, the processing module is used for: In response to receiving a sample detection instruction, determining whether the reaction module has been cleaned within a target period; wherein, the target period is the period between the moment when the reagent module last finished delivering reagents and the current moment; In response to the reaction module having been cleaned within the target period, discarding the liquid in the reagent delivery pipeline, and then controlling the reagent module to deliver the reagent to the reaction module, so that the reaction module is used to prepare a sample solution based on the reagent for sample detection.

2. The sample detection device according to claim 1, wherein, The processing module is further used for: In response to the reaction module not having been cleaned within the target period, controlling the reagent module to deliver the reagent to the reaction module, so that the reaction module is used to prepare a sample solution based on the reagent for sample detection.

3. The sample detection device according to claim 1 or 2, characterized in that, The reaction module is the module indicated by the sample detection instruction to be used; The step of, in response to receiving a sample detection instruction, determining whether the reaction module has been cleaned within a target period includes: In response to receiving a sample detection instruction and the reaction module being an infrequently used reaction module, determining whether the duration of the target period is greater than a preset duration; wherein, the infrequently used reaction module is a reaction module with a usage frequency less than a preset usage frequency threshold; In response to the duration of the target period not being greater than the preset duration, determining whether the reaction module has been cleaned within the target period; The processing module is further used for: In response to the duration of the target period being greater than the preset duration, discarding the liquid in the reagent delivery pipeline, and then controlling the reagent module to deliver the reagent to the reaction module, so that the reaction module is used to prepare a sample solution based on the reagent for sample detection.

4. The sample detection device according to claim 3, wherein, The step of, in response to receiving a sample detection instruction, determining whether the reaction module has been cleaned within a target period includes: In response to receiving a sample detection instruction and the reaction module being a frequently used reaction module, determining whether the reaction module has been cleaned within the target period.

5. The sample detection device according to claim 1 or 2, characterized in that, The step of, in response to the reaction module having been cleaned within the target period, discarding the liquid in the reagent delivery pipeline, and then controlling the reagent module to deliver the reagent to the reaction module, so that the reaction module is used to prepare a sample solution based on the reagent for sample detection includes: In response to the reaction module having been cleaned within the target period, determining the cleaning degree of the cleaning; In response to the cleaning degree being greater than a preset cleaning degree threshold, discarding the liquid in the reagent delivery pipeline, and then controlling the reagent module to deliver the reagent to the reaction module, so that the reaction module is used to prepare a sample solution based on the reagent for sample detection.

6. The sample detection device according to claim 5, characterized in that, The processing module is further used for: In response to the cleaning degree being not greater than a preset cleaning degree threshold, control the reagent module to deliver the reagent to the reaction module, so that the reaction module is used to prepare a sample solution based on the reagent for sample detection.

7. The sample detection device according to claim 6, wherein, The cleaning degree is positively correlated with the cleaning intensity of the cleaning liquid used in the cleaning, and / or the cleaning degree is positively correlated with the number of cleaning times.

8. The sample detection device according to claim 1 or 2, characterized in that, The sample detection device further includes: An in-machine cleaning liquid module for storing the cleaning liquid; An out-of-machine cleaning liquid module for storing the cleaning liquid; The processing module is further configured to: Obtain a user cleaning liquid selection instruction; In response to the cleaning liquid module indicated by the cleaning liquid selection instruction being the in-machine cleaning liquid module, when cleaning the sample detection device, control the in-machine cleaning liquid module to deliver the cleaning liquid to the modules and liquid paths in the sample detection device that need to be cleaned for cleaning; In response to the cleaning liquid module indicated by the cleaning liquid selection instruction being the out-of-machine cleaning liquid module, when cleaning the sample detection device, control the out-of-machine cleaning liquid module to deliver the cleaning liquid to the modules and liquid paths in the sample detection device that need to be cleaned for cleaning.

9. The sample detection device according to claim 1 or 2, characterized in that, The sample detection device further includes an in-machine cleaning liquid module and / or an out-of-machine cleaning liquid module; The in-machine cleaning liquid module is used to store the cleaning liquid; The out-of-machine cleaning liquid module is used to store the cleaning liquid; The processing module is further configured to: In response to the sample detection device being provided with the in-machine cleaning liquid module and the out-of-machine cleaning liquid module, control the in-machine cleaning liquid module to deliver the cleaning liquid to the modules and liquid paths in the sample detection device that need to be cleaned for cleaning; and / or, In response to the sample detection device being provided with the in-machine cleaning liquid module, control the in-machine cleaning liquid module to deliver the cleaning liquid to the modules and liquid paths in the sample detection device that need to be cleaned for cleaning; and / or, In response to the sample detection device being provided with the out-of-machine cleaning liquid module, control the out-of-machine cleaning liquid module to deliver the cleaning liquid to the modules and liquid paths in the sample detection device that need to be cleaned for cleaning.

10. A sample detection method, characterized in that, Applied to the sample detection device according to any one of claims 1 to 9; The sample detection method includes: In response to receiving a sample detection instruction, determine whether the reaction module has been cleaned within a target period; wherein, the target period is the period between the moment when the reagent module last finished delivering the reagent and the current moment; In response to the reaction module having been cleaned within the target period, discard the liquid in the reagent delivery pipeline, and then control the reagent module to deliver the reagent to the reaction module, so that the reaction module is used to prepare a sample solution based on the reagent for sample detection.

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