Composite ion source device for coupling atmospheric pressure interface orbitrap mass spectrometry

Abstract

The invention discloses a composite ion source device for coupling atmospheric pressure interface orbitrap mass spectrometry, which belongs to the field of mass spectrometry detection and comprises a photo ionization / photo-induced association ionization ionization and ion transmission mechanism, a gas sample introduction mechanism, a high-flux radio frequency vacuum ultraviolet light source mechanism and an ion source and mass spectrometry interface mechanism. By adopting the composite ion source device for coupling the atmospheric pressure interface orbitrap mass spectrum, organic components with different polarities, ionization energy and ion affinity in a complex mixture can be efficiently ionized, and through reasonable structural design, the organic components are coupled with the high-resolution orbitrap mass spectrum with the atmospheric pressure interface, so that the high-resolution orbitrap mass spectrum is obtained. The detection range of complex organic components is widened, and the resolution capability and the detection sensitivity of low-abundance or high-molecular-weight organic components are improved.

Description

Technical Field

[0001] The present invention relates to the field of mass spectrometry detection, and particularly to a composite ion source device for coupling an atmospheric pressure interface orbitrap mass spectrometer. Background Art

[0002] The ion source is the core part of a mass spectrometer, which is used to convert neutral molecules into ions and is the primary link in mass spectrometry analysis, related to the sensitivity, analyzable range, stability, and analysis accuracy of the entire mass spectrometer system. The atmospheric pressure ion source (API) is a technique for ionizing sample molecules under atmospheric pressure conditions. The existing ion sources for coupling atmospheric pressure interface mass spectrometry mainly focus on the chemical ionization (CI) source. However, the online mass spectrometry of the chemical ionization (CI) method is usually based on a certain specific reaction ion. Through the ion-molecule reaction between the ion reactant and the analyte, adduct ions are generated to charge the analyte. The substances that can be detected are restricted by the ion affinity and have strong selectivity, and can only measure specific types of compounds. Chemical ionization (CI) generally has good applicability to polar substances, can effectively ionize and provide complete molecular information, but has poor applicability to non-polar or weakly polar substances and low ionization efficiency.

[0003] In contrast, another soft ionization technique - photoionization, determines whether ionization occurs based on whether the photon energy exceeds the ionization energy of the analyte, and is a broad-spectrum ionization method. Photoionization mass spectrometry usually uses vacuum ultraviolet light generated by excited krypton to ionize the analyte, and the photon energy is about 10 eV. Except for a few small organic molecules with less than 3 carbons and ionization energy higher than 10 eV, it has broad applicability to most polar and non-polar organic compounds. In addition, this ionization form also has many other advantages such as high molecular ion yield, few fragments, simple mass spectrometry interpretation, wide linear dynamic range, and good tolerance to matrix components.

[0004] Photoinduced associative ionization (PAI) is a newly discovered ionization pathway in recent years. Associative ionization generates ions through the collision between neutral molecules (excited or unexcited) and involves the formation of new bonds. Essentially, it neither belongs to direct photoionization nor chemical ionization or dopant-assisted photoionization (i.e., using reagent ions to charge the analyte through ion-molecule reaction). Its ionization efficiency can be increased by dozens or even thousands of times compared with direct photoionization. This process uses both light energy and the chemical energy of forming new bonds to charge the analyte, so it is not restricted by the ionization energy and ion affinity (such as proton affinity) of the analyte and has broad applicability to organic compounds from weak polarity to strong polarity. At the same time, the obtained mass spectrometry diagram is simple and clear, and it is easy to obtain a lower detection limit while achieving high sensitivity.

[0005] It can be seen that if these two ionization techniques are combined, efficient ionization of organic components with different polarities, ionization energies, and ion affinities can be achieved, broadening the detection object range of existing atmospheric pressure ion sources. However, there is currently no relevant report on the composite ion source combining these two ion sources, nor is there a device and design for coupling photoinduced association ionization with atmospheric pressure interface mass spectrometry. Summary of the Invention

[0006] The object of the present invention is to provide a composite ion source device for coupling an atmospheric pressure interface orbitrap mass spectrometer, which integrates two ionization techniques of photoionization and photoinduced association ionization. Based on a high-throughput radio frequency vacuum ultraviolet light source, the photoinduced association ionization and photoionization modes are switched by adding or not adding gaseous CH2Cl2 in the ionization region, so that organic components with different polarities, ionization energies, and ion affinities in complex mixtures can be efficiently ionized. Through reasonable structural design, it is coupled with a high-resolution orbitrap mass spectrometer with an atmospheric pressure interface to broaden the detection range of complex organic components and improve the resolution and detection sensitivity for low-abundance or high-molecular-weight organic components.

[0007] To achieve the above object, the present invention provides a composite ion source device for coupling an atmospheric pressure interface orbitrap mass spectrometer, including a photoionization / photoinduced association ionization ionizer and ion transmission mechanism, a gas injection mechanism, a high-throughput radio frequency vacuum ultraviolet light source mechanism, and an ion source and mass spectrometry interface mechanism. The gas injection mechanism is fixedly connected to the photoionization / photoinduced association ionization ionizer and ion transmission mechanism, the high-throughput radio frequency vacuum ultraviolet light source mechanism is fixedly connected to the photoionization / photoinduced association ionization ionizer and ion transmission mechanism, and the ion source and mass spectrometry interface mechanism is fixedly connected to the photoionization / photoinduced association ionization ionizer and ion transmission mechanism.

[0008] Preferably, the photoionization / photoinduced association ionization ionizer and ion transmission mechanism includes an ion source cavity housing, a metal grid, an ionizer, an ion focusing and introduction electrode, and an ion source exhaust pipe. The ionizer is hermetically connected to the gas injection mechanism, and a metal grid is provided at the connection. The ionizer and the ion focusing and introduction electrode are located inside the ion source cavity housing, and ion source exhaust pipes are symmetrically arranged at the upper and lower parts of the ion source cavity housing.

[0009] Preferably, the gas injection mechanism includes a sample gas injection pipe and a sheath gas injection pipe. Both the sample gas injection pipe and the sheath gas injection pipe are stainless steel pipes. The sheath gas is symmetrically introduced from both radial sides of the sheath gas injection pipe. The sample gas injection pipe is located inside the sheath gas injection pipe and is coaxially arranged with the sheath gas injection pipe.

[0010] Preferably, the gas introduced into the sheath gas injection pipe is 0.01% - 10% CH2Cl2, and the auxiliary gas is N2 or He.

[0011] Preferably, the high-throughput radio frequency vacuum ultraviolet light source mechanism includes a discharge gas flow chamber, a discharge gas inlet pipe, a discharge gas outlet pipe, a radio frequency excitation coil, a radio frequency power supply, a sealing ring, a magnesium fluoride lens, a discharge gas flow chamber sealing cover, and a magnesium fluoride lens sealing cover. The discharge gas inlet pipe and the discharge gas outlet pipe are located at the upper end of the discharge gas flow chamber and are distributed in a T shape. The radio frequency excitation coil is wound around the lower part of the outer wall of the discharge gas flow chamber. One end of the radio frequency excitation coil is connected to the radio frequency power supply, and the other end is grounded. The bottom end of the discharge gas flow chamber is hermetically connected to the light outlet of the magnesium fluoride lens through a coaxially installed sealing ring, and a sealing cover is fixedly arranged outside the sealing ring.

[0012] Preferably, the discharge gas flow chamber is a cylindrical quartz lamp tube.

[0013] Preferably, the light outlet of the magnesium fluoride lens is hermetically connected to the ionizer, and its light outlet direction is perpendicular to the direction of the sample gas inlet pipe.

[0014] Preferably, the ion source and the mass spectrometry interface mechanism include a mass spectrometry sampling cone, an orbitrap mass spectrometry inlet, and a circuit interface. The mass spectrometry sampling cone is hermetically connected to the outer shell of the ion source cavity. An orbitrap mass spectrometry inlet is provided at the mass spectrometry sampling cone, and there is a channel between the orbitrap mass spectrometry inlet and the mass spectrometry sampling cone. Sampling protective gas passes through the channel. The circuit interface is embedded in the cavity outer shell above the orbitrap mass spectrometry inlet, used to enable the orbitrap mass spectrometry to identify ion signals, and provide the required electrode voltage and sampling protective gas for the mass spectrometry through the orbitrap mass spectrometry.

[0015] Preferably, the ion focusing introduction electrode is a hollow circular stainless steel plate, which is coaxially and insulatedly installed with the circular hole at the outlet of the ionizer and the mass spectrometry sampling cone.

[0016] Preferably, the mass spectrometry sampling cone is coaxially installed with the sample gas inlet pipe.

[0017] The principle of the present invention is as follows: Using the PAI technology, the gaseous CH2Cl2 absorbs VUV light to generate an excited state , inducing trace H2O molecules in the carrier gas to transfer their protons to the analyte, enabling the analyte to be efficiently protonated ( , M represents the analyte molecule).

[0018] Therefore, the present invention adopts the above-mentioned composite ion source device for coupling an atmospheric pressure interface orbitrap mass spectrometry, and has the following beneficial effects: (1) The composite ion source device provided by the present invention can utilize two ionization modes, namely vacuum ultraviolet photoionization and photoinduced association ionization, and has wide applicability to polar and non-polar substances. It is not limited by the ionization energy and ion affinity (such as proton affinity) of the analyte. Through reasonable structural design, it is coupled with a high-resolution orbital trap mass spectrometer with an atmospheric pressure interface to achieve a broadened detection range of complex organic components and improve the resolution and detection sensitivity of low-abundance or high-molecular-weight organic components.

[0019] (2) The radio frequency vacuum ultraviolet lamp capable of stably generating high flux photons can output up to about 10 15 photon / s, effectively solving the problem of low light flux (about 10 11 At the same time, due to the high flux of the light source, the amount of CH2Cl2 reaction gas required can be greatly reduced.

[0020] (3) The present invention uses an ingenious structural design to allow vacuum ultraviolet light to irradiate inside a field-free ionizer with the same electric potential, thereby preventing the photoelectrons generated by the vacuum ultraviolet light irradiating the metal from being accelerated by the electric field to cause the electron ionization of the reaction gas or background gas, and using the ionizer as a whole as a repelling electrode and an ion focusing introduction electrode to form a focusing electric field to pull the ions. This design is significantly different from other ion source designs and is a unique design suitable for the photoinduced association ionization method. In addition, the vacuum ultraviolet light irradiation direction is perpendicular to the ion transmission direction, thereby preventing the vacuum ultraviolet light from irradiating the metal electrode of the ion transmission system through the ionizer outlet to generate photoelectrons, which are accelerated by the electric field to cause the electron ionization of the reaction gas or background gas.

[0021] (4) The entire ion source device is small in size and compact in structure. When combined with a high-resolution orbital trap mass spectrometer, it can not only expand the detection range of complex organic components, but also improve the species recognition ability and detection sensitivity of low-abundance or high-molecular-weight organic components. It has broad application prospects in the fields of process monitoring and online monitoring of environmental pollution.

[0022] The technical solution of the present invention is further described in detail below through the accompanying drawings and embodiments. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 It is a structural diagram of an embodiment of a composite ion source device for coupling an atmospheric pressure interface orbital trap mass spectrometer according to the present invention.

[0024] Reference numerals 1. Ion source cavity housing; 2. Sheath gas inlet tube; 3. Sample gas inlet tube; 4. Metal grid; 5. Ionizer; 6. Ion focusing and introduction electrode; 7. Discharge gas flow chamber; 8. Discharge gas inlet pipe; 9. Discharge gas outlet pipe; 10. RF excitation coil; 11. RF power supply; 12. Sealing ring; 13. Magnesium fluoride lens; 14. Sealing cover of the discharge gas flow chamber; 15. Sealing cover of the magnesium fluoride lens; 16. Ground state CH2Cl2 molecule; 17. Excited state CH2Cl2 molecule; 18. Sample molecule; 19. Sample ion; 20. Circuit interface; 21. Mass spectrometry sampling cone; 22. Ion source exhaust pipe; 23. Sampling protective gas; 24. Orbitrap mass spectrometry inlet. Detailed implementation manners

[0025] The technical solutions of the present invention will be further described below with reference to the accompanying drawings and embodiments.

[0026] Unless otherwise defined, the technical terms or scientific terms used in the present invention shall have the ordinary meanings understood by those of ordinary skill in the field to which the present invention belongs. The "first", "second" and similar terms used in the present invention do not indicate any order, quantity or importance, but are only used to distinguish different components. The terms such as "including" or "comprising" mean that the elements or objects appearing before the term cover the elements or objects listed after the term and their equivalents, without excluding other elements or objects. The terms such as "connected" or "coupled" are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect. The terms such as "upper", "lower", "left" and "right" are only used to indicate relative position relationships, and when the absolute positions of the objects being described change, the relative position relationships may also change accordingly.

[0027] Embodiment 1 As Figure 1As shown in the figure, the present invention provides a composite ion source device for coupling an atmospheric pressure interface orbitrap mass spectrometer, which includes a photoionization / photoinduced association ionization ionization and ion transmission mechanism, a gas injection mechanism, a high-throughput radio frequency vacuum ultraviolet light source mechanism, and an ion source and mass spectrometer interface mechanism. The gas injection mechanism is fixedly connected to the photoionization / photoinduced association ionization ionization and ion transmission mechanism, the high-throughput radio frequency vacuum ultraviolet light source mechanism is fixedly connected to the photoionization / photoinduced association ionization ionization and ion transmission mechanism, and the ion source and mass spectrometer interface mechanism is fixedly connected to the photoionization / photoinduced association ionization ionization and ion transmission mechanism. The photoionization / photoinduced association ionization ionization and ion transmission mechanism is used to ionize sample molecules 18 to generate sample ions 19, and to transmit and focus the sample ions 19 to ensure that the sample ions 19 can be efficiently transmitted to the mass spectrometry sampling cone 21 connected to the mass spectrometry end. The gas injection mechanism is used to transport sample gas, reaction gas, and auxiliary gas. The high-throughput radio frequency vacuum ultraviolet light source mechanism is used to generate vacuum ultraviolet light. The ion source and mass spectrometer interface mechanism is used to enable the orbitrap mass spectrometer to identify ion signals, and to provide the required electrode voltage and sampling protection gas 23 for the ion source through the orbitrap mass spectrometer.

[0028] The photoionization / photoinduced association ionization ionization and ion transmission mechanism includes an ion source cavity housing 1, a metal grid 4, an ionizer 5, an ion focusing and introducing electrode 6, and an ion source exhaust pipe 22. The ion source cavity housing 1 is used for the support, loading of internal components of the ion source, and sealed connection with the mass spectrometer; the ionizer 5 and the ion focusing and introducing electrode 6 are located inside the ion source cavity housing 1. The ionizer 5 is used to generate sample ions 19 from sample molecules 18 by photoionization or photoinduced association ionization; the ion focusing and introducing electrode 6 is a hollow circular stainless steel plate, which is coaxially and insulatedly installed with the round hole at the outlet of the ionizer 5 and the mass spectrometry sampling cone 21, and is used to transmit and focus the sample ions 19 to ensure that the sample ions 19 can be efficiently transmitted to the mass spectrometry sampling cone 21 connected to the mass spectrometry end; the ionizer 5 is hermetically connected to the gas injection mechanism, and a metal grid 4 is provided at the connection to make the entire ionization region have the same electric potential, avoiding vacuum ultraviolet light irradiating on the inner surface of the metal ionizer 5 to generate photoelectrons, and the photoelectrons are accelerated by the electric field to break the ground state CH2Cl2 molecules 16 by electron ionization or ionize background molecules to generate background ions; ion source exhaust pipes 22 are symmetrically arranged at the upper and lower parts of the ion source cavity housing 1, and they are connected to a vacuum pump through valves and are used to maintain the vacuum environment required by the ion source.

[0029] The gas sampling mechanism includes a sample gas sampling tube 3 and a sheath gas sampling tube 2, both of which are stainless steel tubes. The sheath gas sampling tube 2 is of a T-shaped structure. The sample gas sampling tube 3 is located inside the sheath gas sampling tube 2 and is coaxial with the vertical branch tube of the sheath gas sampling tube 2. The sample gas sampling tube 3 is used for the stable sampling of sample gas, and the sheath gas sampling tube 2 is used for the stable sampling of auxiliary gas N2 or He and reaction gas CH2Cl2. The auxiliary gas is used to form a laminar flow to make the sample gas flow stably through the ionizer 5. At the same time, N2 or He is used to replace air to reduce the absorption loss of O2 components in the air to vacuum ultraviolet light. By changing the flow rate of the auxiliary gas, the air pressure of the ion source can be adjusted to achieve the optimal detection efficiency; the reaction gas CH2Cl2 is used to generate excited state CH2Cl2 molecules 17 under the irradiation of vacuum ultraviolet light, inducing photoinduced associative ionization.

[0030] The high-throughput radio frequency vacuum ultraviolet light source mechanism includes a discharge gas flow chamber 7, a discharge gas inlet pipe 8, a discharge gas outlet pipe 9, a radio frequency excitation coil 10, a radio frequency power supply 11, a sealing ring 12, a magnesium fluoride lens 13, a discharge gas flow chamber sealing cover 14 and a magnesium fluoride lens sealing cover 15. The discharge gas inlet pipe 8 and the discharge gas outlet pipe 9 are located at the upper end of the discharge gas flow chamber 7 and are distributed in a T shape. The radio frequency excitation coil 10 is wound around the lower part of the outer wall of the discharge gas flow chamber 7. One end of the radio frequency excitation coil 10 is connected to the radio frequency power supply 11, and the other end is grounded. The bottom end of the discharge gas flow chamber 7 is hermetically connected to the light outlet of the magnesium fluoride lens 13 through a coaxially installed sealing ring 12, and a sealing cover is fixedly arranged outside the sealing ring 12. The discharge gas generates a luminous plasma under the action of radio frequency and releases heat. Due to the thermal expansion and contraction effect, the discharge gas maintains heat exchange and flow in the lower half and the upper half of the discharge gas flow chamber 7, so as to maintain the purity of the discharge gas in the discharge gas flow chamber 7 and realize the stable output of high-throughput vacuum ultraviolet light.

[0031] The discharge gas flow chamber 7 is a cylindrical quartz lamp tube. The light outlet of the magnesium fluoride lens 13 is hermetically connected to the ionizer 5, and its light outlet direction is perpendicular to the direction of the sample gas sampling tube 3, so that the irradiation direction of the vacuum ultraviolet light is perpendicular to the migration directions of the sample molecules 18 and the sample ions 19, avoiding the leakage of vacuum ultraviolet light to the ion migration region. The vacuum ultraviolet light irradiates on the metal electrode to generate photoelectrons, and under the action of the ion migration electric field, the ground state CH2Cl2 molecules 16 are broken or the background molecules are ionized to generate background ions to generate excited state CH2Cl2 molecules 17 in the way of electron ionization.

[0032] The ion source and mass spectrometry interface mechanism includes a circuit interface 20, a mass spectrometry sampling cone 21, and an orbitrap mass spectrometry inlet 24. The circuit interface 20 is embedded in the cavity housing 1 above the orbitrap mass spectrometry inlet 24, and is used to enable the orbitrap mass spectrometry to identify ion signals, and provide the required electrode voltage and sampling protective gas 23 for the mass spectrometry through the orbitrap mass spectrometry. The mass spectrometry sampling cone 21 is hermetically connected to the ion source cavity housing 1. An orbitrap mass spectrometry inlet 24 is provided at the mass spectrometry sampling cone 21, and there is a channel between the orbitrap mass spectrometry inlet 24 and the mass spectrometry sampling cone 21, through which the sampling protective gas 23 passes. The mass spectrometry sampling cone 21 is coaxially installed with the sample gas inlet tube 3.

[0033] When the composite ion source device for coupling an atmospheric pressure interface orbitrap mass spectrometry provided by the present invention is in use, it includes the following steps: Step 1: Continuously introduce and flow out krypton gas as the discharge gas through the discharge gas inlet pipe 8 and the discharge gas outlet pipe 9 above the discharge gas flow chamber 7. The discharge gas generates high-flux vacuum ultraviolet light under the action of the radio frequency excitation coil 10, releases heat, and the generated vacuum ultraviolet light enters the ionizer 5 through the magnesium fluoride lens 13.

[0034] Step 2: The sample molecules 18 are stably introduced into the ion source cavity housing 1 through the sample gas inlet tube 3. The auxiliary gas (N2 or He) and the reaction gas (CH2Cl2) are stably introduced through the sheath gas inlet tube 2 coaxial with the sample gas inlet tube 3, and enter the ionizer 5 through the metal grid 4.

[0035] Step 3: When gaseous CH2Cl2 is not introduced into the ionization region, the sample molecules 18 are directly ionized by single-photon ionization under the action of vacuum ultraviolet light to form sample ions 19. When gaseous CH2Cl2 is introduced into the ionization region, the ground-state CH2Cl2 molecules 16 generate excited-state CH2Cl2 molecules 17 under the irradiation of vacuum ultraviolet light, and induce trace H2O molecules in the carrier gas to transfer their protons to other sample molecules 18, and the sample molecules 18 are efficiently protonated to form sample ions 19.

[0036] Step 4: The generated sample ions 19 flow out of the ionizer 5 under the traction of the flow field. The ionizer 5 itself serves as a repulsion electrode, and forms an ion focusing and transmission electric field with the ion focusing introduction electrode 6 to focus and guide the sample ions 19. The sample ions 19 are efficiently transmitted to the mass spectrometry sampling cone 21 connected to the mass spectrometry end, and then enter the orbitrap mass spectrometry inlet 24 and are thus detected.

[0037] Therefore, the present invention adopts the above-mentioned composite ion source device for coupling an atmospheric pressure interface Orbitrap mass spectrometer, enabling efficient ionization of organic components with different polarities, ionization energies, and ion affinities in a complex mixture. Through a reasonable structural design, it is coupled with a high-resolution Orbitrap mass spectrometer with an atmospheric pressure interface, realizing the broadening of the detection range of complex organic components and improving the resolution and detection sensitivity for low-abundance or high-molecular-weight organic components.

[0038] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit them. Although the present invention has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that they can still modify or equivalently replace the technical solutions of the present invention, and these modifications or equivalent replacements do not cause the modified technical solutions to deviate from the spirit and scope of the technical solutions of the present invention.

Claims

1. A composite ion source device for coupling an atmospheric pressure interface orbitrap mass spectrometer, characterized in that: It includes a photoionization / photoinduced associative ionization and ionization and ion transport mechanism, a gas sampling mechanism, a high-throughput radio frequency vacuum ultraviolet light source mechanism, and an ion source and mass spectrometry interface mechanism. The gas sampling mechanism is fixedly connected to the photoionization / photoinduced associative ionization and ionization and ion transport mechanism. The high-throughput radio frequency vacuum ultraviolet light source mechanism is fixedly connected to the photoionization / photoinduced associative ionization and ionization and ion transport mechanism. The ion source and mass spectrometry interface mechanism is fixedly connected to the photoionization / photoinduced associative ionization and ionization and ion transport mechanism.

2. The composite ion source device for coupling an atmospheric pressure interface orbitrap mass spectrometer according to claim 1, wherein: The photoionization / photoinduced associative ionization and ionization and ion transport mechanism includes an ion source cavity housing, a metal grid, an ionizer, an ion focusing and introducing electrode, and an ion source exhaust pipe. The ionizer is hermetically connected to the gas sampling mechanism, and a metal grid is provided at the connection. The ionizer and the ion focusing and introducing electrode are located inside the ion source cavity housing. Ion source exhaust pipes are symmetrically arranged at the upper and lower parts of the ion source cavity housing.

3. The composite ion source device for coupling an atmospheric pressure interface orbitrap mass spectrometer according to claim 2, characterized in that: The gas sampling mechanism includes a sample gas inlet pipe and a sheath gas inlet pipe. Both the sample gas inlet pipe and the sheath gas inlet pipe are stainless steel pipes. The sheath gas is symmetrically introduced from the radial two sides of the sheath gas inlet pipe. The sample gas inlet pipe is located inside the sheath gas inlet pipe and is coaxially arranged with the sheath gas inlet pipe.

4. The composite ion source device for coupling an atmospheric pressure interface orbitrap mass spectrometer according to claim 3, characterized in that: The gas introduced into the sheath gas inlet pipe is 0.01% - 10% CH₂Cl₂, and the auxiliary gas is N₂ or He.

5. The composite ion source device for coupling an atmospheric pressure interface orbitrap mass spectrometer according to claim 3, wherein: The high-throughput radio frequency vacuum ultraviolet light source mechanism includes a discharge gas flow chamber, a discharge gas inlet pipe, a discharge gas outlet pipe, a radio frequency excitation coil, a radio frequency power supply, a sealing ring, a magnesium fluoride lens, a discharge gas flow chamber sealing cover, and a magnesium fluoride lens sealing cover. The discharge gas inlet pipe and the discharge gas outlet pipe are located at the upper end of the discharge gas flow chamber and are distributed in a T shape. The radio frequency excitation coil is wound around the outer wall below the discharge gas flow chamber. One end of the radio frequency excitation coil is connected to the radio frequency power supply, and the other end is grounded. The bottom end of the discharge gas flow chamber is hermetically connected to the light outlet of the magnesium fluoride lens through a coaxially installed sealing ring, and a sealing cover is fixedly provided outside the sealing ring.

6. The composite ion source device for coupling an atmospheric pressure interface orbitrap mass spectrometer according to claim 5, characterized in that: The discharge gas flow chamber is a cylindrical quartz lamp tube.

7. The composite ion source device for coupling an atmospheric pressure interface orbitrap mass spectrometer according to claim 5, wherein: The light outlet of the magnesium fluoride lens is hermetically connected to the ionizer, and its light output direction is perpendicular to the direction of the sample gas inlet pipe.

8. The composite ion source device for coupling an atmospheric pressure interface orbitrap mass spectrometer according to claim 3, wherein: The ion source and mass spectrometry interface mechanism includes a mass spectrometry sampling cone, an orbitrap mass spectrometry inlet, and a circuit interface. The mass spectrometry sampling cone is hermetically connected to the ion source cavity housing. An orbitrap mass spectrometry inlet is provided at the mass spectrometry sampling cone, and there is a channel between the orbitrap mass spectrometry inlet and the mass spectrometry sampling cone, and sampling protective gas passes through the channel. The circuit interface is embedded in the cavity housing above the orbitrap mass spectrometry inlet.

9. The composite ion source device for coupling an atmospheric pressure interface orbitrap mass spectrometer according to claim 8, characterized in that: The ion focusing and introducing electrode is a hollow circular stainless steel plate, and it is coaxially and insulatedly installed with the circular hole at the outlet of the ionizer and the mass spectrometry sampling cone.

10. The composite ion source device for coupling an atmospheric pressure interface orbitrap mass spectrometer according to claim 8, wherein: The mass spectrometry sampling cone is coaxially installed with the sample gas inlet pipe.

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