Position calibration system

Abstract

The invention discloses a position calibration system for nucleic acid detection equipment with a motion module, and the position calibration system comprises a calibration tool which is matched with the nucleic acid detection equipment and is used for detecting the motion module; the calibration tool and the nucleic acid detection equipment are both in communication connection with the analysis calibration device; the analysis calibration device is configured to obtain calibration input information and equipment information of the nucleic acid detection equipment; obtaining a to-be-calibrated bit and a calibration operation instruction in combination with the calibration input information and the equipment information; the movement module is controlled to drive the calibration tool to move to the position to be calibrated; starting calibration, and issuing the calibration operation instruction to the nucleic acid detection equipment. The position calibration system combines the equipment information of the nucleic acid detection equipment and the calibration input information, automatically calibrates the positions to be calibrated of different types of nucleic acid detection equipment, and is high in calibration compatibility, calibration precision and calibration efficiency.

Description

Technical Field

[0001] The present invention belongs to the technical field of position calibration, and particularly relates to a position calibration system. Background Art

[0002] Point-of-care testing (POCT) is a testing method that is carried out at the sampling site and uses portable analytical instruments and supporting reagents to quickly obtain test results. In the existing scenario, the position calibration method of nucleic acid testing equipment before leaving the factory is done manually with the assistance of manual tooling, which takes a long time, has poor consistency, low calibration accuracy, and the calibration accuracy seriously depends on the professional skills of users.

[0003] Moreover, due to the need for sample testing, there are currently various types of nucleic acid testing equipment on the market. After the nucleic acid testing equipment has been used at the client for a period of time, due to the high professionalism of calibration and the different calibration requirements of different types of nucleic acid testing equipment, customers cannot calibrate the instrument by themselves, which greatly affects the after-sales maintenance cost and the customer experience. Summary of the Invention

[0004] The purpose of the present invention is to provide a position calibration system to solve the technical problem of difficult after-sales maintenance of nucleic acid testing equipment in the prior art.

[0005] To achieve the above purpose, on the one hand, the present invention provides a position calibration system for a nucleic acid testing equipment with a motion module. The position calibration system includes:

[0006] A calibration tooling, which is adapted to the nucleic acid testing equipment and is used to detect the motion module;

[0007] An analysis and calibration device, to which the calibration tooling and the nucleic acid testing equipment are both communicatively connected;

[0008] The analysis and calibration device is configured to:

[0009] Obtain calibration input information and the equipment information of the nucleic acid testing equipment;

[0010] Combine the calibration input information and the equipment information to obtain the position to be calibrated and a calibration operation instruction;

[0011] Control the motion module to drive the calibration tooling to move to the position to be calibrated;

[0012] Start calibration and send the calibration operation instruction to the nucleic acid testing equipment.

[0013] In an embodiment of the present invention, the calibration input information includes a mode input instruction, and the analysis and calibration device is further configured to:

[0014] Determine that the mode input instruction includes the standard mode, and obtain the calibration operation instruction and the position to be calibrated according to the device information;

[0015] Determine that the mode input instruction includes the custom mode, and obtain the calibration operation instruction and the position to be calibrated according to the calibration input information.

[0016] In an embodiment of the present invention, the calibration input information further includes a position input instruction, and the analysis and calibration device is further configured to:

[0017] Determine that the calibration input information includes the custom mode, and obtain the position input instruction;

[0018] Determine the custom options according to the position input instruction, and the custom options include at least one or more of a Y-axis amplification position, a Y-axis extraction position, a Z-axis extraction position, and an S-axis extraction position.

[0019] In an embodiment of the present invention, the analysis and calibration device is further configured to:

[0020] Obtain the current position detection information of the calibration tooling for the position to be calibrated;

[0021] Calculate the calibration deviation value of the position to be calibrated;

[0022] Determine that the calibration deviation value is less than the preset deviation value, and mark the current position of the position to be calibrated as the calibration position.

[0023] In an embodiment of the present invention, the position to be calibrated includes at least a Y-axis amplification position and a Z-axis extraction position.

[0024] In an embodiment of the present invention, the calibration tooling includes a profiling main body and a calibration mechanism installed on the profiling main body. The profiling main body is adapted to the nucleic acid detection device. The calibration mechanism includes a position adjustment member and a first detector. The position adjustment member cooperates with the first detector under the pushing of the nucleic acid detection device and detects the current position of the Y-axis amplification position. The second detector is used to detect the current position of the Z-axis extraction position.

[0025] In an embodiment of the present invention, the analysis and calibration device is further configured to:

[0026] Determine that the calibration mechanism is not set, and control the motion module to move to a preset position;

[0027] Determine that the current position exceeds the preset position, and shut down the motion module;

[0028] Determine that the current position does not exceed the preset position and the calibration mechanism is set, and mark the current position of the calibration mechanism as the calibration position.

[0029] In an embodiment of the present invention, the analysis and calibration device is configured to:

[0030] Obtain the number of calibration items and the calibration sequence in the calibration operation instruction;

[0031] Perform calibration operations in sequence according to the calibration sequence;

[0032] Feed back the calibration completion instruction.

[0033] In an embodiment of the present invention, the nucleic acid detection device further includes an experimental module for sample detection, and the analysis and calibration device is further configured to:

[0034] Determine that the calibration tooling enters the nucleic acid detection device and lock the experimental module.

[0035] In an embodiment of the present invention, the analysis and calibration device is integrated into one of the calibration tooling or the nucleic acid detection device.

[0036] Through the above technical solutions, the position calibration system provided by the embodiments of the present invention has the following beneficial effects:

[0037] When performing position calibration using the position calibration system in this embodiment, the calibration tooling can be first placed in the consumable card position of the nucleic acid detection device, and the calibration tooling, the nucleic acid detection device, and the analysis and calibration device are communicatively connected. When the analysis and calibration device determines that the calibration tooling has entered the nucleic acid detection device, it can obtain the calibration input information. Based on the calibration input information and the device information of the nucleic acid detection device, the analysis and calibration device can obtain the position to be calibrated and the calibration operation instruction, which has high compatibility for different device types, and can control the motion module to drive the calibration tooling to the position to be calibrated according to the calibration operation instruction. Without relying on the user's professional technology, it can achieve automatic control with high precision, issue a calibration operation instruction to the nucleic acid detection device, and can control the motion module to perform precise calibration motion further. The position calibration system of the present invention combines the device information of the nucleic acid detection device and the calibration input information to automatically calibrate the positions to be calibrated of different types of nucleic acid detection devices, with high calibration compatibility, calibration accuracy, and calibration efficiency.

[0038] Other features and advantages of the embodiments of the present invention will be described in detail in the subsequent specific embodiment part. BRIEF DESCRIPTION OF THE DRAWINGS

[0039] The accompanying drawings are used to provide a further understanding of the embodiments of the present invention and form a part of the specification. Together with the following specific embodiments, they are used to explain the embodiments of the present invention, but do not constitute a limitation to the embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on the structures shown in these drawings. In the drawings:

[0040] Figure 1 is the control flowchart of the position calibration system according to an embodiment of the present invention;

[0041] Figure 2 is the control flowchart of the position calibration system according to another embodiment of the present invention;

[0042] Figure 3 is the control flowchart of the position calibration system according to still another embodiment of the present invention;

[0043] Figure 4 is the control flowchart of the position calibration system according to another embodiment of the present invention;

[0044] Figure 5 is the control flowchart of the position calibration system according to an embodiment of the present invention;

[0045] Figure 6 is the control flowchart of the position calibration system according to another embodiment of the present invention;

[0046] Figure 7 is the schematic diagram of the calibration input information selection;

[0047] Figure 8 is the schematic diagram of the structural principle of the position calibration system according to an embodiment of the present invention;

[0048] Figure 9 is the structural diagram of the position calibration system according to another embodiment of the present invention;

[0049] Figure 10 is the structural diagram of the position calibration system according to an embodiment of the present invention;

[0050] Figure 11 is the structural diagram of the calibration tooling of the position calibration system according to an embodiment of the present invention from one perspective;

[0051] Figure 12 is the structural diagram of the calibration tooling of the position calibration system according to an embodiment of the present invention from another perspective;

[0052] Figure 13 is the structural diagram of the calibration tooling of the position calibration system according to another embodiment of the present invention from one perspective;

[0053] Figure 14 It is a schematic structural diagram of a calibration tooling of a position calibration system in another perspective according to another embodiment of the present invention.

[0054] Description of reference numerals

[0055] Label Name Label Name

[0056] 100 Calibration tooling 22 First detector

[0057] 1 Profiling main body 23 Second detector

[0058] 11 Sliding cavity 24 Third detector

[0059] 12 Upper mounting cavity 25 Elastic reset member

[0060] 2 Calibration mechanism 3 Temperature probe

[0061] 21 Position adjustment and measurement member 4 Temperature detector

[0062] 211 Sliding main body 200 Nucleic acid detection device

[0063] 212 Limiting ear 210 Pipette tip Detailed implementation manners

[0064] The following will describe in detail the specific implementation manners of the present invention with reference to the accompanying drawings. It should be understood that the specific implementation manners described herein are only for explaining and interpreting the present invention, and are not used to limit the present invention.

[0065] Next, refer to the attached Figures 1 to 14 Describe a position calibration system according to the present invention. The position calibration system is used for a nucleic acid detection device 200 with a motion module. The position calibration system includes a calibration tooling 100 and an analysis and calibration device. The calibration tooling 100 is adapted to the nucleic acid detection device 200 and is used to detect the motion module. The analysis and calibration device is communicatively connected to the calibration tooling 100 and the nucleic acid detection device 200.

[0066] As Figure 1 shown, in one embodiment, the analysis and calibration device is configured to:

[0067] Obtain calibration input information and device information of the nucleic acid detection device 200;

[0068] Combine the calibration input information and the device information to obtain the position to be calibrated and a calibration operation instruction;

[0069] Control the motion module to drive the calibration tooling to move to the position to be calibrated;

[0070] Start calibration and send a calibration operation instruction to the nucleic acid detection device 200.

[0071] Understandably, the calibration input information can be a human-machine instruction, a network instruction, etc. The analysis and calibration device can collect human-machine instructions through a touch screen or an instruction button. The standard mode in this embodiment can be preset, and the corresponding standard mode can be preset according to different device types. The nucleic acid detection device 200 can be a POCT all-in-one machine. The motion module can drive the calibration tooling 100 to move along the Y-axis, that is, the front-back direction. The nucleic acid detection device 200 further includes a pipetting module with a pipette tip 210, a device control module, a communication module, and a detection reaction module. The analysis and calibration device can send a calibration operation instruction to the device control module. The device control module can generate a motion module control instruction during position calibration according to the calibration operation instruction. The motion module can include a motion motor. The calibration tooling 100 adopts a profiling design and is adapted to the nucleic acid detection device 200.

[0072] In addition, according to whether the nucleic acid detection device 200 can perform rotational motion, the nucleic acid detection device 200 can be divided into device types with and without S-axis drive. In one embodiment, the pipetting module includes a pipetting pump with a pipette tip 210. The motion module in this embodiment further includes a Y-axis drive, a Z-axis drive, and an S-axis drive. Among them, the Z-axis drive and the S-axis drive are both connected to the pipetting module. The Y-axis drive, the Z-axis drive, and the S-axis drive can all adopt stepper motors. The Z-axis drive can drive the pipette tip 210 in the up-down direction, and the S-axis drive can drive the pipette tip 210 to rotate along the horizontal plane.

[0073] When performing position calibration using the position calibration system in this embodiment, the calibration tooling 100 can be first placed in the consumable card slot of the nucleic acid detection device 200, and the calibration tooling 100, the nucleic acid detection device 200, and the analysis and calibration device are communicatively connected. When the analysis and calibration device determines that the calibration tooling 100 has entered the nucleic acid detection device 200, it can obtain the calibration input information. The analysis and calibration device can obtain the position to be calibrated and the calibration operation instruction according to the calibration input information and the device information of the nucleic acid detection device 200. It has high compatibility for different device types, and can control the motion module to drive the calibration tooling to move to the position to be calibrated according to the calibration operation instruction. Without relying on the user's professional technology, it can achieve automatic control with high precision. By sending a calibration operation instruction to the nucleic acid detection device 200, it can control the motion module to further perform precise calibration motion. The position calibration system in this embodiment combines the device information of the nucleic acid detection device 200 and the calibration input information to automatically calibrate the positions to be calibrated of different types of nucleic acid detection devices 200, with high calibration compatibility, calibration accuracy, and calibration efficiency.

[0074] Specifically, the calibration input information includes a mode input instruction, such as Figure 2 As shown, the analysis and calibration device is further configured to:

[0075] The determination mode input instruction includes a standard mode, and calibration operation instructions and positions to be calibrated are obtained according to device information;

[0076] The determination mode input instruction includes a custom mode, and calibration operation instructions and positions to be calibrated are obtained according to calibration input information.

[0077] Calibration mode confirmation is performed. When it is determined that the calibration mode is the standard mode, the standard mode is the standard mode of the nucleic acid detection device 200. Calibration operation instructions can be obtained according to the device information of the nucleic acid detection device 200, and the device information can include device type and historical calibration operation data. The analysis and calibration device can control the motion module to drive the calibration tooling 100 to move according to the calibration operation instructions and determine the calibration value of the motion module. The position calibration system in this embodiment can provide users with the option to select the calibration mode, without requiring users to have high professional skills, and has good calibration flexibility. By identifying and calibrating the input information through the nucleic acid detection device 200 to obtain the calibration mode, standardized calibration or custom calibration can be performed, and the position calibration requirements for different calibration scenarios, different calibration devices, and different calibration modes can be met, reducing the difficulty of after-sales maintenance for positions to be calibrated.

[0078] As Figures 3 to 7 shown, in one embodiment, the calibration input information further includes a position input instruction, and the analysis and calibration device is further configured to:

[0079] Determine that the calibration input information includes a custom mode and obtain the position input instruction;

[0080] Determine custom options according to the position input instruction, and the custom options include at least one or more of the Y-axis amplification position, Y-axis extraction position, Z-axis extraction position, and S-axis extraction position.

[0081] In this embodiment, the Y-axis is the front-back direction, the Z-axis is the up-down direction, and the S-axis extraction position is used to calibrate the rotational position of the pipette tip 210 in the horizontal plane. When the calibration input information is input in a human-computer interaction manner, the user can select the Y-axis amplification position, Y-axis extraction position, Z-axis extraction position, and S-axis extraction position according to different needs, and different positions can be achieved. In the case where a single position needs to be calibrated, only a single position can be selected. In the case where multiple positions need to be calibrated, multiple positions can be selected, further improving the compatibility of the position calibration system. After the custom options are selected, the analysis and calibration device can generate corresponding calibration operation instructions for different custom options and control the nucleic acid detection device to perform calibration operations in the corresponding order according to the calibration operation instructions.

[0082] In one embodiment, the analysis and calibration device is further configured to:

[0083] Obtain the current position detection information of the calibration tooling for the position to be calibrated;

[0084] Calculate the calibration deviation value of the position to be calibrated;

[0085] Determine that the calibration deviation value is less than the preset deviation value, and mark the current position of the position to be calibrated as the calibration position.

[0086] In this embodiment, the analysis and calibration device can obtain the default position information and the current position detection information of the position to be calibrated according to the detection of the motion module of the calibration tooling, calculate the calibration deviation value, and when it is determined that the calibration deviation value is less than the preset deviation value, mark the current position of the position to be calibrated as the calibration position. In the case where the calibration deviation value is greater than or equal to the preset deviation value, the calibration fails, and the analysis and calibration device can give an alarm for calibration failure. The analysis and calibration device can control the motion module to reset and shut down the motion module.

[0087] In one embodiment, the positions to be calibrated include at least a Y-axis amplification position and a Z-axis extraction position.

[0088] As Figures 8 to 14 shown, the calibration tooling 100 includes a profiling main body 1 and a calibration mechanism 2 installed on the profiling main body 1. The profiling main body 1 is adapted to the nucleic acid detection device 200. The calibration mechanism 2 includes a position adjustment member 21 and a first detector 22. The position adjustment member 21 cooperates with the first detector 22 under the pushing of the nucleic acid detection device 200 and detects the current position of the Y-axis amplification position. A second detector 23 is used to detect the current position of the Z-axis extraction position.

[0089] In this embodiment, the first detector 22 and the second detector 23 can adopt photoelectric sensors to perform position detection through photoelectric induction. The positions to be calibrated further include a Y-axis extraction position and an S-axis extraction position. The second detector 23 is also used to detect the current position of the Y-axis extraction position. The calibration mechanism 2 further includes an elastic reset member 25. The elastic reset member 25 is located between the position adjustment member 21 and the profiling main body 1. The position adjustment member 21 can cooperate with the profiling main body 1 to compress the elastic reset member 25 under the pushing of the PCR module, and the elastic reset member 25 can drive the position adjustment member 21 to reset.

[0090] The profiling main body 1 is provided with a sliding cavity 11. The position adjustment member 21 is accommodated in the sliding cavity 11. One end of the sliding cavity 11 is provided with a telescopic opening, and the other end of the sliding cavity 11 is provided with a limiting block for limiting the position adjustment member 21. The position adjustment member 21 includes a sliding main body 211 and a limiting ear. The sliding main body 211 extends along the Y-axis; the limiting ear protrudes along the Z-axis from the edge of the sliding main body 211. The sliding cavity 11 is provided with a limiting portion corresponding to the limiting ear, and the size of the limiting portion is larger than the size of the limiting ear.

[0091] As Figures 13 to 14As shown, in one embodiment, the calibration mechanism 2 further includes a third detector 24. The third detector 24 can be an optoelectronic sensor and is used to detect the current position of the S-axis extraction position. The position with a state of 0 is detected by the optoelectronic sensor, where 1 represents being blocked by the pipette tip 210 and 0 represents not being blocked by the pipette tip 210. The first detector 22, the second detector 23, and the third detector 24 are all optoelectronic sensors; the second detector 23 can also be used to detect the motion module of the Y-axis extraction position, and an upper mounting cavity 12 is provided at the upper end of the profiling body 1. The second detector 23 and the third detector 24 are both accommodated in the upper mounting cavity 12.

[0092] In one embodiment, a temperature probe 3 for adapting to the PCR module is provided at the front end of the calibration tool 100 in the Y-axis direction. The temperature probe 3 is detachably connected to the profiling body 1 and can detect the heating temperature of the PCR module, so as to facilitate the analysis of the temperature calibration of the calibration device. In one embodiment, a heating module is provided on the nucleic acid detection device 200, and a temperature detector 4 for detecting the heating temperature of the heating module can be installed on the profiling body 1, which can facilitate the analysis of the heating calibration of the calibration device for the heating module.

[0093] In one embodiment, the analysis and calibration device is further configured to:

[0094] Determine that the calibration mechanism 2 is not set, and control the motion module to perform a step motion towards a preset position;

[0095] Determine that the current position exceeds the preset position, and shut down the motion module;

[0096] Determine that the current position does not exceed the preset position and the calibration mechanism 2 is set, and mark the current position of the calibration mechanism 2 as the calibration position.

[0097] The preset position in this embodiment can be set according to actual usage requirements. In the case where it is determined that the current position exceeds the preset position, the calibration fails, and the analysis and calibration device can give an alarm for calibration failure. In the case where it is determined that the current position does not exceed the preset position and the calibration mechanism 2 is set, the current position of the calibration mechanism 2 is marked as the calibration position.

[0098] It should be noted that the analysis and calibration device is configured to:

[0099] Obtain the number of calibration items and the calibration sequence in the calibration operation instruction;

[0100] Perform calibration operations in sequence according to the calibration sequence;

[0101] Feedback the calibration completion instruction.

[0102] Such as Figures 3 to 6As shown, in one embodiment, after performing the reset operation of the motion module, it is then sequentially determined whether to perform the Y-axis amplification position calibration, Y-axis extraction position calibration, Z-axis extraction position calibration, and S-axis extraction position calibration, and the initial position of the position to be calibrated is obtained. During the Y-axis amplification position calibration, the analysis calibration device first sends the Y-axis amplification initial position to the motion module. The Y-axis amplification initial position is equal to the Y-axis amplification default value + the Y-axis calibration range value, causing the calibration tooling 100 to move to the Y-axis amplification initial position, and determining whether the calibration mechanism 2 is set. In the case where the calibration mechanism 2 is set in the first determination, a Y-axis calibration out-of-range alarm is given.

[0103] Specifically, the analysis calibration device is further configured to:

[0104] Determine that the calibration mechanism 2 is not set, and control the motion module to perform a step motion from the Y-axis amplification initial position to the Y-axis amplification preset position;

[0105] Determine that the current position exceeds the Y-axis amplification preset position, shut down the motion module and give a calibration failure alarm.

[0106] During the Y-axis amplification position calibration, the analysis calibration device controls the motion module to drive the calibration tooling 100 to move to the Y-axis amplification initial position, and determines whether the calibration mechanism 2 is set. In the case where the calibration mechanism 2 is not set, the analysis calibration device controls the motion module to perform a step motion from the Y-axis amplification initial position to the Y-axis amplification preset position, making adjustments with the minimum adjustment distance, and determining whether the current position exceeds the Y-axis amplification preset position. The Y-axis amplification preset position is equal to the Y-axis amplification default value - the amplification calibration range value. In the case where the current position exceeds the Y-axis amplification preset position, the analysis calibration device shuts down the motion module and gives a calibration failure alarm. In this embodiment, in the case where the calibration tooling 100 exceeds the preset position, it can be determined that the calibration deviation value of the motion module is relatively large, avoiding the situation where the nucleic acid detection device 200 cannot be used normally due to continued calibration in the case of a relatively large calibration deviation value.

[0107] As Figure 5 shown, during the Y-axis amplification position calibration, the analysis calibration device controls the motion module to perform a step motion from the initial position to the preset position, making adjustments with the minimum adjustment distance, and determining whether the current position exceeds the Y-axis amplification preset position. In the case where the current position does not exceed the Y-axis amplification preset position and the calibration mechanism 2 is set, record the Y-axis current position as the Y-axis current calibration value, and the Y-axis amplification position calibration is successful, and the amplification position calibration process ends. In this embodiment, driving the calibration tooling 100 to perform a step motion with the minimum adjustment distance, combined with photoelectric position detection, can greatly improve the accuracy of the position calibration system. Without the need for users to have high professional skills, high-precision calibration of the nucleic acid detection device 200 can be achieved, greatly improving the convenience of after-sales maintenance of the nucleic acid detection device 200.

[0108] In this embodiment, for the amplification position and extraction position of the nucleic acid detection device 200, through precise motion control of the stepper motor and precise position information obtained by the photoelectric sensor, the extraction position and amplification position of the nucleic acid detection device 200 can be automatically calibrated with one key, and the position calibration accuracy is within ±0.2 mm.

[0109] The analysis and calibration device controls the motion module to perform Z-axis extraction position calibration. As Figure 6 shown, the analysis and calibration device can first control the motion module to move along the Y-axis to the Y-axis extraction position, and then determine the device type of the nucleic acid detection device 200. Whether it is a nucleic acid detection device 200 with an S-axis drive. In the case where it is determined that the nucleic acid detection device 200 is a device type without an S-axis drive, control the motion module to drive the pipette tip 210 along the Z-axis to the Z-axis initial position. The Z-axis initial position is equal to the Z-axis extraction default value + the Z-axis calibration range value. After the calibration tooling 100 is in place, determine whether the calibration mechanism 2 is in place, that is, whether the calibration mechanism 2 generates an in-place photoelectric detection signal. In the case where the calibration mechanism 2 is at the Z-axis initial position and not in place, the analysis and calibration device can perform a Z-axis calibration out-of-range alarm.

[0110] In the case where the calibration mechanism 2 is at the Z-axis initial position and in place, the analysis and calibration device can control the Z-axis drive of the motion module to drive the calibration tooling 100 upward in a step motion with the minimum adjustment distance, and determine that the current position of the motion module does not exceed the Z-axis preset position. The Z-axis preset position is equal to the Z-axis extraction default value - the calibration range value. In the case where the current position of the motion module does not exceed the Z-axis preset position and the calibration mechanism 2 is not in place, record the current position of the motion module as the calibration value.

[0111] In the embodiment of the present invention, the nucleic acid detection device 200 further includes an experiment module for sample detection. The experiment module in this embodiment is a PCR module. The analysis and calibration device is further configured to:

[0112] Determine that the calibration tooling 100 enters the nucleic acid detection device 200 and locks the experiment module.

[0113] The nucleic acid detection device 200 in this embodiment can detect the calibration tooling 100 and send tooling in-place information to the analysis and calibration device. The analysis and calibration device determines that the calibration tooling 100 is in place and locks the experiment module, which can prohibit the experiment operation of the experiment module, avoid the situation of misoperation of the nucleic acid detection device 200 by the user during the calibration process, and improve the calibration safety of the calibration system.

[0114] In the embodiment of the present invention, the analysis and calibration device is integrated in one of the calibration tooling 100 or the nucleic acid detection device 200.

[0115] As Figures 8 to 10As shown, in one embodiment, the analysis and calibration device, the calibration tooling 100, and the nucleic acid detection device 200 are independent of each other. The analysis and calibration device is set separately. The position analysis operation device can be a computer, a notebook, a mobile phone, etc. The position analysis operation device can include a control module, a display and interaction module, a storage module, a communication module, and a device identification module. The device identification module can analyze the device type, usage, and historical calibration information of the nucleic acid detection device 200 through the device information reported by the nucleic acid detection device 200. The display and interaction module can display the relevant operation steps and parameters of the current position calibration through the user interface, and can obtain the requirements for the position to be calibrated input by the user through the man-machine interaction method. The storage module is used to preset the default position, the position calibration standard parameters, and store the position calibration historical data. The calibration tooling 100 further includes a power supply module, a control circuit board, and a communication module. In the process of the analysis and calibration device in this embodiment controlling the motion module to drive the calibration tooling 100 for position calibration, it can control the display and interaction module to display the relevant operation steps and parameters of the current position calibration. The analysis and calibration device, the calibration tooling 100, and the nucleic acid detection device 200 can be communicatively connected through a cable or a WIFI module.

[0116] Figure 8 The analysis and calibration device in it establishes a communication connection with the nucleic acid detection device 200 through a wired or wireless network; taking an external computer as an example, through the Ethernet method, the nucleic acid detection device 200 enters the static IP automatic setting, and then the calibration tooling 100 establishes a communication connection serial port mode with the analysis and calibration device through the USB interface, and performs calibration control through the external computer method. In another embodiment, the analysis and calibration device is integrated into one of the calibration tooling 100 or the nucleic acid detection device 200.

[0117] In one embodiment, the calibration input information further includes the position to be analyzed, and the analysis and calibration device is further configured to obtain at least one of the position to be calibrated and the position to be analyzed according to the position input instruction. The analysis and calibration device in this embodiment can control the nucleic acid detection device 200 to enter the custom mode. Compared with the standard mode, it can further obtain the position to be calibrated and the position to be analyzed. When a professional calibrates the nucleic acid detection device 200, they can select the position to be calibrated and the position to be analyzed according to specific needs, making the position calibration system more compatible with different calibration requirements.

[0118] Such as Figure 7As shown, the user can select the position to be calibrated and the position to be analyzed from the Y-axis amplification position, Y-axis extraction position, Z-axis extraction position, and S-axis extraction position. After the selection of the position to be calibrated and the position to be analyzed is completed, the analysis and calibration device can control the motion module to perform a calibration operation. The analysis and calibration device can detect the current position through the calibration tooling 100. In this embodiment, the calibration tooling 100 can adopt photoelectric detection. And calculate the calibration deviation value of the position to be analyzed. The analysis and calibration device can display the calibration deviation value of the position to be analyzed, which is convenient for the user to master the position deviation situation of the current nucleic acid detection device 200, making it more user-friendly. The analysis and calibration device can send the calibration deviation value of the position to be calibrated to the nucleic acid detection device 200, and replace the default position in the nucleic acid detection device 200 with the current position.

[0119] In another embodiment, the analysis and calibration device first calculates and displays the calibration deviation value for one or more of the Y-axis amplification position, Y-axis extraction position, Z-axis extraction position, and S-axis extraction position for the user to select the subsequent position to be analyzed and the position to be calibrated. When the calibration deviation value is small, the user can select position calibration. When the calibration deviation value is large, the user can not select position calibration. As Figure 3 shown, in the embodiment of the present invention, the analysis and calibration device is further configured to:

[0120] Start timing while performing position calibration;

[0121] Determine that the calibration duration exceeds the preset duration, control the motion module to reset and give an overtime alarm.

[0122] In this embodiment, the analysis and calibration device starts calibration timing while controlling the motion module to drive the calibration tooling 100 to perform position calibration, and judges whether the calibration duration exceeds the preset duration. The preset duration in this embodiment can be 5 minutes. When the calibration duration exceeds 5 minutes, an overtime alarm is given, and the user can obtain the fault information of the position calibration system as soon as possible.

[0123] In the description of the present invention, it should be understood that the terms "first" and "second" are only used for descriptive purposes and cannot be construed as indicating or implying relative importance or implicitly indicating the quantity of the indicated technical features. Thus, the features defined with "first" and "second" may explicitly or implicitly include at least one of the features. In the description of the present invention, "a plurality" means at least two, such as two, three, etc., unless otherwise specifically defined.

[0124] In the present invention, unless otherwise clearly specified or limited, the terms "mounted", "connected", "coupled", "fixed", etc. shall be construed in a broad sense. For example, it may be a fixed connection, a detachable connection, or integrated; it may be a mechanical connection, an electrical connection, or capable of communicating with each other; it may be directly connected, or indirectly connected through an intermediate medium, and may be the internal communication of two components or the interaction relationship between two components, unless otherwise clearly limited. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0125] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples", etc. means that the specific features, structures, materials, or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described may be combined in any one or more embodiments or examples in a suitable manner. In addition, without contradiction, those skilled in the art can combine and combine the different embodiments or examples described in this specification and the features of different embodiments or examples.

[0126] Although the embodiments of the present invention have been shown and described above, it can be understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those of ordinary skill in the art can make changes, modifications, substitutions, and variations to the above embodiments within the scope of the present invention.

Claims

1. A position calibration system for a nucleic acid detection device (200) with a motion module, characterized in that, The position calibration system includes: A calibration tooling (100), which is adapted to the nucleic acid detection device (200) and is used to detect the motion module; An analysis and calibration device, to which the calibration tooling (100) and the nucleic acid detection device (200) are both communicatively connected; The analysis and calibration device is configured to: Obtain calibration input information and device information of the nucleic acid detection device (200); Combine the calibration input information and the device information to obtain the position to be calibrated and a calibration operation instruction; Control the motion module to drive the calibration tooling to move to the position to be calibrated; Start calibration and send the calibration operation instruction to the nucleic acid detection device (200).

2. The position calibration system according to claim 1, characterized in that, The calibration input information includes a mode input instruction, and the analysis and calibration device is further configured to: Determine that the mode input instruction includes the standard mode, and obtain the calibration operation instruction and the position to be calibrated according to the device information; Determine that the mode input instruction includes the custom mode, and obtain the calibration operation instruction and the position to be calibrated according to the calibration input information.

3. The position calibration system according to claim 2, wherein The calibration input information further includes a position input instruction, and the analysis and calibration device is further configured to: Determine that the calibration input information includes the custom mode and obtain the position input instruction; Determine custom options according to the position input instruction, and the custom options include at least one or more of the Y-axis amplification position, the Y-axis extraction position, the Z-axis extraction position, and the S-axis extraction position.

4. The position calibration system according to claim 1, characterized in that, The analysis and calibration device is further configured to: Obtain the current position detection information of the calibration tooling for the position to be calibrated; Calculate the calibration deviation value of the position to be calibrated; Determine that the calibration deviation value is less than the preset deviation value, and mark the current position of the position to be calibrated as the calibration position.

5. The position calibration system according to any one of claims 1 to 4, characterized in that, The position to be calibrated includes at least the Y-axis amplification position and the Z-axis extraction position.

6. The position calibration system according to claim 5, wherein The calibration tooling (100) includes a profiling main body (1) and a calibration mechanism (2) installed on the profiling main body (1). The profiling main body (1) is adapted to the nucleic acid detection device (200). The calibration mechanism (2) includes a position adjustment part (21) and a first detector (22). The position adjustment part (21) cooperates with the first detector (22) under the push of the nucleic acid detection device (200) and detects the current position of the Y-axis amplification position. A second detector (23) is used to detect the current position of the Z-axis extraction position.

7. The position calibration system according to claim 6, wherein The analysis and calibration device is further configured to: Determine that the calibration mechanism (2) is not set, and control the motion module to move to a preset position; Determine that the current position exceeds the preset position, and shut down the motion module; Determine that the current position does not exceed the preset position and the calibration mechanism (2) is set, and mark the current position of the calibration mechanism (2) as the calibration position.

8. The position calibration system according to any one of claims 1 to 4, characterized in that The analysis and calibration device is configured to: Obtain the number of calibration items and the calibration sequence in the calibration operation instruction; Perform calibration operations in sequence according to the calibration sequence; Feed back a calibration completion instruction.

9. The position calibration system according to any one of claims 1 to 4, characterized in that, The nucleic acid detection device (200) further includes an experiment module for sample detection, and the analysis and calibration device is further configured to: Determine that the calibration tooling (100) enters the nucleic acid detection device (200) and lock the experimental module.

10. The position calibration system according to any one of claims 1 to 4, characterized in that, The analysis and calibration device is integrated in one of the calibration tooling (100) or the nucleic acid detection device (200).

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