Inhibitor cream for treating psoriasis and preparation method thereof

Abstract

The invention relates to the technical field of psoriasis inhibitors, and provides an inhibitor emulsifiable paste for treating psoriasis and a preparation method thereof, the component of the inhibitor emulsifiable paste is a small-molecule inhibitor RR6, and the molecular formula of the inhibitor emulsifiable paste is C16H23NO4. The invention relates to a preparation method of an inhibitor cream for treating psoriasis, which comprises the following steps: 1) weighing 25mg of RR6, and dissolving RR6 in 200mu L of DMSO for later use; (2) preparing an oil phase by using equipment needing to be prepared, including a constant-temperature heating magnetic stirrer and a beaker; 3) adding lauryl sodium sulfate, glycerol and water into another beaker according to a ratio of 1: 7: 70, and heating and dissolving to obtain a water phase of the cream; and 4) adding the water phase into the oil phase, stirring for 10 minutes, finally adding the RR6 solution, stirring for 10 minutes, cooling at room temperature, and storing at 4 DEG C to obtain the formed inhibitor cream. According to the technical scheme, the problems that an existing inhibitor cream for treating psoriasis and a preparation method of the inhibitor cream are many and complex in raw material, high in cost and common in treatment effect are solved.

Description

Technical Field

[0001] The present invention relates to the technical field of psoriasis inhibitors, and specifically, to an inhibitor cream for treating psoriasis and a preparation method thereof. Background Art

[0002] Psoriasis is a chronic, non-infectious autoimmune disease, mainly characterized by the over-proliferation of skin cells leading to the formation of squamous plaques; its inhibitor cream is mainly a paste used to treat psoriasis, which is absorbed by the skin through means such as smearing and massaging to improve the skin condition;

[0003] For example, a cyclosporine cream for treating lupus erythematosus or psoriasis, its preparation method and application with the authorized announcement number CN104958754B. In this invention, by determining the scientific compatibility of the emulsifier and the oil phase, a high transmittance of cyclosporine through the skin is ensured, and further, it is jointly prepared with dexamethasone acetate to obtain a cream. The cream can directly act on the affected area, exerting the synergistic effect of the immunosuppressive and anti-inflammatory pharmacological mechanisms of cyclosporine and dexamethasone acetate, obtaining a better effect on treating the skin symptoms of lupus erythematosus and psoriasis, and local medication is safer and more effective; the invention provides a preparation method of the cream, which is simple, easy to operate, with mild conditions and easy to promote.

[0004] However, the above-mentioned existing inhibitor cream for treating psoriasis and its preparation method have many and complex raw materials, high costs and general treatment effects. Therefore, we propose an inhibitor cream for treating psoriasis and a preparation method thereof. Summary of the Invention

[0005] The present invention proposes an inhibitor cream for treating psoriasis and a preparation method thereof, solving the existing problems in the related technology.

[0006] The technical solution of the present invention is as follows:

[0007] An inhibitor cream for treating psoriasis, whose ingredient is a small molecule inhibitor RR6, and its molecular formula is C 16 H 23 NO4.

[0008] A preparation method of an inhibitor cream for treating psoriasis, and the preparation method is as follows:

[0009] 1) Weigh 25 mg of RR6 and dissolve it in 200 μL of DMSO for standby;

[0010] 2) The equipment to be prepared includes a thermostatic heating magnetic stirrer and a beaker. Add stearyl alcohol, white petrolatum, p-hydroxybenzoic acid and glyceryl monostearate into the beaker according to the ratio of 40:60:1:20, and then put it into a preheated thermostatic heating magnetic stirrer at 70 °C, and heat and dissolve it in a water bath at 70 °C to obtain the oil phase of the paste;

[0011] 3) Add sodium dodecyl sulfate, glycerol and water into another beaker in a ratio of 1:7:70, heat and dissolve to obtain the aqueous phase of the cream.

[0012] 4) Add the aqueous phase into the oil phase and stir for 10 min. Finally, add the RR6 solution and stir for 10 min, then cool at room temperature and store at 4 °C to obtain the formed inhibitor cream.

[0013] As a further technical solution of the present invention, the constant-temperature heating magnetic stirrer includes a housing. A constant-temperature component is arranged inside the beaker, and the constant-temperature component is used to keep the temperature inside the beaker constant. An adjusting structure is arranged between the housing and the inside of the beaker. The adjusting structure includes a pushing component arranged inside the housing and a following component arranged inside the beaker. The pushing component is used to adjust the acting height of the following component, and the following component is used to stir the liquid in the beaker. The following component includes a rotating rod rotatably arranged inside the beaker.

[0014] As a further technical solution of the present invention, control buttons for controlling the operation of the entire stirrer are arranged on the outer surface of the housing. A display screen for displaying the operation state of the stirrer is fixedly connected to the outer surface of the housing. A rotating part is rotatably connected inside the housing, and a rotating magnetic block is fixedly connected to the outer surface of the rotating part. The rotating magnetic block drives the rotating rod to rotate through magnetic force.

[0015] As a further technical solution of the present invention, the pushing component includes a micro electric cylinder fixedly connected to one end of the inner wall surface of the housing. The output end of the micro electric cylinder is fixedly connected with a ring, and a first magnetic block is fixedly connected to the upper end surface of the ring.

[0016] As a further technical solution of the present invention, the upper end of the rotating rod is rotatably connected with a connecting block. An extension rod is fixedly connected to the outer surface of the connecting block, and a movable ring is fixedly connected to the other end of the extension rod. A second magnetic block is fixedly connected to the lower end of the movable ring, and a limiting slider is fixedly connected to the outer surface of the movable ring. A sliding groove for the limiting slider to slide up and down is arranged on the inner side surface of the beaker.

[0017] As a further technical solution of the present invention, the number of the micro electric cylinders is several groups and is distributed in a circular array. The ring is of a circular structure, and the number of the first magnetic blocks is several groups and is distributed in a circular array. The height of the ring is adjusted by the extension or contraction of the micro electric cylinder.

[0018] As a further technical solution of the present invention, the rotating rod and the connecting block are rotatably connected through a bearing, and the number of the extension rods is several groups and is distributed in a circular array.

[0019] As a further technical solution of the present invention, the movable ring slides up and down along the inner side of the beaker. The number of the second magnetic blocks is equal to that of the first magnetic blocks, and their positions correspond one by one. The first magnetic blocks push the second magnetic blocks to move up and down through repulsive force.

[0020] As a further technical solution of the present invention, the limiting slider is slidably connected to the beaker. The position of the movable ring is restricted by the limiting slider so as not to shift. The limiting slider slides up and down along the chute. The number of the limiting sliders and chutes is several groups and they are distributed in an annular array.

[0021] The working principle and beneficial effects of the present invention are as follows:

[0022] 1. In the present invention, through the production of the cream, the method is simple and the raw materials are less, which can facilitate production while reducing production costs, and has good therapeutic effects in use.

[0023] 2. Through the function of the adjustment structure of the present invention, during the use process, the working height of the rotating rod for stirring can be freely adjusted according to the needs of the user, so that the raw materials at different positions can be mixed and stirred, and thus the purpose of sufficient stirring can be quickly achieved. At the same time, the friction between the rotating rotating rod and the inner wall of the lower end of the beaker can be avoided. Description of the Drawings

[0024] Figure 1 is a schematic structural diagram of the constant temperature heating magnetic stirrer of the present invention together with the beaker;

[0025] Figure 2 is of the present invention Figure 1 a schematic structural diagram from another perspective;

[0026] Figure 3 is of the present invention Figure 2 a partially sectional schematic structural diagram from another perspective;

[0027] Figure 4 is of the present invention Figure 3 a partially enlarged structural diagram;

[0028] Figure 5 is of the present invention Figure 4 a partially sectional schematic structural diagram from another perspective;

[0029] Figure 6 is of the present invention Figure 5 a partially sectional schematic structural diagram from another perspective;

[0030] Figure 7 is a partially sectional top view of the limiting slider of the present invention;

[0031] Figure 8The molecular structure of the inhibitor for treating psoriasis in the present invention;

[0032] Figure 9 The comparison diagram of the treatment of mice in the present invention.

[0033] In the figure: 1. Outer shell; 2. Beaker; 3. Adjusting structure; 31. Pushing component; 311. Micro electric cylinder; 312. Ring; 313. First magnetic block; 32. Following component; 321. Rotating rod; 322. Connecting block; 323. Extension rod; 324. Movable ring; 325. Second magnetic block; 326. Limit slider; 4. Control button; 5. Display screen; 6. Rotating part; 7. Rotating magnetic block. Detailed implementation manners

[0034] Next, in combination with the embodiments of the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments in the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts fall within the scope of protection of the present invention.

[0035] Embodiment 1

[0036] As Figure 8 shown, this embodiment proposes an inhibitor cream for treating psoriasis, the component of which is a small molecule inhibitor RR6, and its molecular formula is C 16 H 23 NO4.

[0037] Embodiment 2

[0038] As Figures 1 to 7 shown, a preparation method of an inhibitor cream for treating psoriasis is as follows:

[0039] 1) Weigh 25 mg of RR6 and dissolve it in 200 μL of DMSO for standby;

[0040] 2) The equipment to be prepared includes a thermostatic heating magnetic stirrer and a beaker 2. Add stearyl alcohol, white petrolatum, p-hydroxybenzoic acid and glyceryl monostearate into the beaker 2 according to the ratio of 40:60:1:20, and then put it into the preheated thermostatic heating magnetic stirrer at 70 °C for water bath heating and dissolution to obtain the oil phase of the paste;

[0041] 3) Add sodium dodecyl sulfate, glycerol and water into another beaker 2 according to the ratio of 1:7:70, and heat and dissolve to obtain the water phase of the cream;

[0042] 4) Add the aqueous phase to the oil phase and stir for 10 min. Finally, add the RR6 solution and stir for 10 min. Then cool at room temperature and store at 4 °C to obtain the formed inhibitor cream.

[0043] The constant-temperature heating magnetic stirrer includes a housing 1. A constant-temperature component is arranged inside the beaker 2, and the constant-temperature component is used to keep the temperature inside the beaker 2 constant. An adjusting structure 3 is arranged between the housing 1 and the inside of the beaker 2. The adjusting structure 3 includes a pushing component 31 arranged inside the housing 1 and a following component 32 arranged inside the beaker 2. The pushing component 31 is used to adjust the acting height of the following component 32, and the following component 32 is used to stir the liquid in the beaker 2. The following component 32 includes a rotating rod 321 rotatably arranged inside the beaker 2.

[0044] Control buttons 4 for controlling the operation of the entire stirrer are arranged on the outer surface of the housing 1. A display screen 5 for displaying the operation state of the stirrer is fixedly connected to the outer surface of the housing 1. A rotating part 6 is rotatably connected inside the housing 1. A rotating magnet 7 is fixedly connected to the outer surface of the rotating part 6, and the rotating magnet 7 drives the rotating rod 321 to rotate through magnetic force.

[0045] The pushing component 31 includes a micro-electric cylinder 311 fixedly connected to one end of the inner wall surface of the housing 1. The output end of the micro-electric cylinder 311 is fixedly connected to a ring 312, and a first magnet 313 is fixedly connected to the upper surface of the ring 312.

[0046] The upper end of the rotating rod 321 is rotatably connected to a connecting block 322. An extension rod 323 is fixedly connected to the outer surface of the connecting block 322. The other end of the extension rod 323 is fixedly connected to a movable ring 324. A second magnet 325 is fixedly connected to the lower end of the movable ring 324. A limiting slider 326 is fixedly connected to the outer surface of the movable ring 324, and a sliding groove for the limiting slider 326 to slide up and down is formed on the inner side surface of the beaker 2.

[0047] The number of the micro-electric cylinders 311 is several groups and is distributed in a circular array. The ring 312 is a circular structure. The number of the first magnets 313 is several groups and is distributed in a circular array. The height of the ring 312 is adjusted by the extension or contraction of the micro-electric cylinder 311.

[0048] The rotating rod 321 and the connecting block 322 are rotatably connected through a bearing. The number of the extension rods 323 is several groups and is distributed in a circular array.

[0049] The movable ring 324 slides up and down along the inner side of the beaker 2. The number of the second magnets 325 is equal to the number of the first magnets 313, and their positions correspond one by one. The first magnet 313 pushes the second magnet 325 to move up and down through repulsive force.

[0050] The limiting slider 326 is slidably connected to the beaker 2. The position of the movable ring 324 is restricted by the limiting slider 326 so that it does not shift. The limiting slider 326 slides up and down along the chute. The number of the limiting sliders 326 and the chutes is several groups and they are distributed in an annular array.

[0051] In this embodiment, through the production of the cream, the method is simple and the raw materials are few, which can facilitate production while reducing production costs, and has good therapeutic effects in use.

[0052] During the use process, the working height of the rotating rod 321 for stirring can be freely adjusted according to the needs of the user, so that the raw materials at different positions can be mixed and stirred, and thus the purpose of sufficient stirring can be quickly achieved. At the same time, the friction between the rotating rotating rod 321 and the inner wall of the lower end of the beaker 2 can be avoided.

[0053] During the use process, the user can control the micro-electric cylinder 311 to extend through the control button 4. At this time, the micro-electric cylinder 311 drives the ring 312 upward, so that the ring 312 moves upward. The first magnetic block 313 is driven to move upward synchronously by the ring 312. During the upward movement of the first magnetic block 313, the second magnetic block 325 can be pushed upward by the repulsive force. The movable ring 324 together with the extension rod 323 and the connecting block 322 are driven to move upward synchronously by the second magnetic block 325. During the upward movement of the connecting block 322, the rotating rod 321 can be driven to move upward synchronously. During the upward movement of the rotating rod 321, it will rotate synchronously for stirring, so that the height of the stirring position of the rotating rod 321 can be freely adjusted according to the needs of the user, achieving a better stirring effect. The role of the chute and the limiting slider 326 can restrict the movable ring 324 from shifting and can only move up and down. On the contrary, by contracting the micro-electric cylinder 311, the height of the action of the rotating rod 321 can be adjusted to move downward.

[0054] Embodiment 3

[0055] As Figure 9 shown, in this embodiment, the inhibitor cream for treating psoriasis obtained by the present invention is used to conduct experiments on mice. Among them, CONTORL, that is, the normal group has two mice, IMG, that is, two groups of psoriasis mice in the model group, and IMG+RR6, that is, two psoriasis mice in the treatment group. By applying the cream of the present invention, the skin of the treatment group finally smeared with the cream is close to the skin of the normal group mice, which can show the therapeutic effect of the cream of the present invention on psoriasis.

[0056] In the experiment, it is effective to compare with the use of the control cream at a concentration of 0.1%-1% for the mice.

[0057] In summary, the working principle of the present invention is specifically as follows:

[0058] During the process of using the constant temperature heating magnetic stirrer, the user can place the raw materials inside the beaker 2, and then start it by pressing the control button 4, which can cause the rotating part 6 to rotate. The rotating rotating part 6 drives the rotating rod 321 to rotate accordingly. The rotation of the rotating rod 321 can fully stir and mix the raw materials inside the beaker 2 until it stops after the required time or state.

[0059] During the use, the user can control the extension of the micro electric cylinder 311 through the control button 4. At this time, the micro electric cylinder 311 drives the ring 312 upward, causing the ring 312 to move upward. The ring 312 drives the first magnetic block 313 to move upward synchronously. During the upward movement of the first magnetic block 313, the second magnetic block 325 can be pushed upward by the repulsive force. The second magnetic block 325 drives the movable ring 324, together with the extension rod 323 and the connecting block 322, to move upward synchronously. During the upward movement of the connecting block 322, it can drive the rotating rod 321 to move upward synchronously. During the upward movement of the rotating rod 321, it will rotate synchronously while stirring, so that the height of the stirring position of the rotating rod 321 can be freely adjusted according to the needs of the user, achieving a better stirring effect. The chute and the limit slider 326 can prevent the movable ring 324 from shifting and only allow it to move up and down. Conversely, by contracting the micro electric cylinder 311, the height of the action of the rotating rod 321 can be adjusted to move downward.

[0060] The above are only the preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. An inhibitor cream for treating psoriasis, characterized in that, Its component is the small molecule inhibitor RR6, and its molecular formula is C 16 H 23 NO4.

2. A method for preparing an inhibitor cream for treating psoriasis, which is used to prepare the inhibitor cream for treating psoriasis according to claim 1, characterized in that, The preparation method is as follows: 1) Weigh 25 mg of RR6 and dissolve it in 200 μL of DMSO for later use; 2) The equipment to be prepared includes a thermostatic heating magnetic stirrer and a beaker (2). Add stearyl alcohol, white petrolatum, p-hydroxybenzoic acid, and glyceryl monostearate into beaker (2) in a ratio of 40:60:1:20, and then place it in a preheated thermostatic heating magnetic stirrer at 70 °C and heat it in a water bath at 70 °C to dissolve, obtaining the oil phase of the paste; 3) Add sodium dodecyl sulfate, glycerol, and water into another beaker (2) in a ratio of 1:7:70, heat and dissolve to obtain the aqueous phase of the cream; 4) Add the aqueous phase to the oil phase and stir for 10 min. Finally, add the RR6 solution and stir for 10 min, then cool it at room temperature and store it at 4 °C to obtain the formed inhibitor cream.

3. The preparation method of the inhibitor cream for treating psoriasis according to claim 2, characterized in that, The thermostatic heating magnetic stirrer includes a housing (1). A thermostatic component is arranged inside the beaker (2), and the thermostatic component is used to keep the temperature inside the beaker (2) constant. An adjusting structure (3) is arranged between the housing (1) and the inside of the beaker (2). The adjusting structure (3) includes a jacking component (31) arranged inside the housing (1) and a following component (32) arranged inside the beaker (2). The jacking component (31) is used to adjust the acting height of the following component (32), and the following component (32) is used to stir the liquid in the beaker (2). The following component (32) includes a rotating rod (321) rotatably arranged inside the beaker (2).

4. The preparation method of the inhibitor cream for treating psoriasis according to claim 1, characterized in that, Control buttons (4) for controlling the operation of the entire stirrer are arranged on the outer surface of the housing (1). A display screen (5) for displaying the operation status of the stirrer is fixedly connected to the outer surface of the housing (1). A rotating part (6) is rotatably connected inside the housing (1). A rotating magnet (7) is fixedly connected to the outer surface of the rotating part (6), and the rotating magnet (7) drives the rotating rod (321) to rotate through magnetic force.

5. The preparation method of the inhibitor cream for treating psoriasis according to claim 3, characterized in that, The jacking component (31) includes a micro electric cylinder (311) with one end fixedly connected to the inner wall surface of the housing (1). The output end of the micro electric cylinder (311) is fixedly connected to a ring (312), and a first magnet (313) is fixedly connected to the upper surface of the ring (312).

6. The preparation method of the inhibitor cream for treating psoriasis according to claim 5, characterized in that, The upper end of the rotating rod (321) is rotatably connected to a connecting block (322). An extension rod (323) is fixedly connected to the outer surface of the connecting block (322). The other end of the extension rod (323) is fixedly connected to a movable ring (324). A second magnet (325) is fixedly connected to the lower end of the movable ring (324). A limiting slider (326) is fixedly connected to the outer surface of the movable ring (324), and a sliding groove for the limiting slider (326) to slide up and down is arranged on the inner side surface of the beaker (2).

7. The preparation method of the inhibitor cream for treating psoriasis according to claim 5, characterized in that, The number of the micro electric cylinders (311) is several groups and they are distributed in a circular array. The circular ring (312) is of a circular structure. The number of the first magnetic blocks (313) is several groups and they are distributed in a circular array. The height of the circular ring (312) is adjusted by the extension or contraction of the micro electric cylinders (311).

8. The preparation method of the inhibitor cream for treating psoriasis according to claim 6, characterized in that, The rotating rod (321) and the connecting block (322) are rotatably connected through a bearing. The number of the extension rods (323) is several groups and they are distributed in a circular array.

9. The preparation method of the inhibitor cream for treating psoriasis according to claim 8, characterized in that, The movable ring (324) slides up and down along the inner side of the beaker (2). The number of the second magnetic blocks (325) is equal to that of the first magnetic blocks (313), and their positions correspond one by one. The first magnetic blocks (313) push the second magnetic blocks (325) to move up and down through repulsive force.

10. The preparation method of the inhibitor cream for treating psoriasis according to claim 9, characterized in that, The limiting slider (326) is slidably connected to the beaker (2). The position of the movable ring (324) is restricted from shifting by the limiting slider (326). The limiting slider (326) slides up and down along the chute. The number of the limiting sliders (326) and the chutes is several groups and they are distributed in a circular array.

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