False tooth adhesive with long-acting adhesion and soft lining functions

Abstract

The invention relates to the technical field of dental restoration materials, and discloses a false tooth adhesive with long-acting adhesion and soft lining functions. The denture adhesive is prepared from the following components in percentage by mass: 20 to 95 weight percent of gum base; 0-20 wt% of a filler; 0-20 wt% of a plasticizer; 0-1 wt% of an antioxidant; 0-2 wt% of a coloring agent; 0-3 wt% of a sweetener; 0-2 wt% of a taste covering agent; 0-3.0 wt% of an antibacterial agent; and the balance of an organic solvent. According to the false tooth adhesive, the non-water-soluble gum base is adopted as a main adhesion component and is not dissolved in saliva, the adhesion time far longer than that of a traditional water-soluble adhesive can be provided, the retention force of a false tooth is effectively maintained, and the frequency of replacing the adhesive by a patient is reduced; in the initial stage of use, the artificial tooth soft lining has good fluidity, can fully fill a gap between an artificial tooth and an oral cavity tissue, can form a soft buffer layer similar to an artificial tooth soft lining between the artificial tooth and the oral cavity tissue, and effectively relieves a pressing pain point; the biological safety is good, so that the use experience of a patient is remarkably improved.

Description

Technical Field

[0001] The present application relates to the technical field of oral restoration materials, and in particular to a denture adhesive with long-lasting adhesion and soft lining functions. Background Art

[0002] Dentures, commonly known as false teeth, are artificial teeth that replace missing natural teeth. Denture adhesives are used to fix dentures. They produce an adhesive effect in the mouth to increase the retention and stability of the dentures, and improve and enhance the chewing ability when eating.

[0003] Currently, denture adhesives on the market mainly rely on water-soluble or hydrogel components, such as poly(vinyl chloride-methyl vinyl ether / maleic anhydride) copolymers and sodium carboxymethyl cellulose. These materials swell by absorbing saliva to form a temporary adhesion between the denture and the oral tissue. However, due to the complexity of the oral environment, such adhesives are easily dissolved, degraded or lose viscosity in saliva, resulting in a rapid attenuation of the adhesion effect, which can usually only last for 8-12 hours. More importantly, after dissolution, such water-soluble adhesives will be swallowed by the patient. Long-term intake may have adverse effects on the body and pose certain safety risks. Although improvements have been made in the formulation and function of adhesives at this stage, the problems of adhesion persistence and biosafety have not been fundamentally solved.

[0004] Based on this, there is an urgent need to develop a new denture adhesive that can provide a longer-lasting and more comfortable retention effect, have good biosafety, and have a soft lining function. Summary of the invention

[0005] The present application provides a denture adhesive with long-lasting adhesion and soft lining functions, aiming to solve the technical problems of poor adhesion durability and biosafety risks of existing denture adhesives.

[0006] In order to achieve the above objectives, the present application adopts the following technical solutions.

[0007] The present application provides a denture adhesive with long-lasting adhesion and soft lining functions, which comprises the following components by mass percentage:

[0008]

[0009] The balance is organic solvent.

[0010] Preferably, the denture adhesive comprises the following components by mass percentage:

[0011]

[0012] The balance is organic solvent.

[0013] Preferably, the gum base comprises at least one of polyvinyl acetate, butyl rubber, polyisobutylene, ethylene-vinyl acetate copolymer, natural gum, vegetable wax or microcrystalline wax.

[0014] Preferably, the plasticizer comprises at least one of triethyl citrate, tributyl acetylcitrate, triacetin, propylene glycol, polyethylene glycol or sorbitol.

[0015] Preferably, the antioxidant comprises at least one of vitamin E, ascorbic acid, rosemary extract or tea polyphenols.

[0016] Preferably, the filler comprises at least one of silica, calcium phosphate, calcium carbonate, hydroxyapatite, microcrystalline cellulose or zinc oxide.

[0017] Preferably, the organic solvent comprises at least one of ethanol, isopropanol, propylene glycol, glycerol, ethyl acetate, triethyl acetate or ethyl lactate.

[0018] Preferably, the colorant comprises at least one of carmine, betanin, curcumin, carotene, titanium dioxide, iron oxide red or iron oxide yellow;

[0019] and / or,

[0020] the sweetener comprises at least one of xylitol, sorbitol, maltitol, isomalt, aspartame, sucralose or acesulfame potassium;

[0021] and / or,

[0022] the flavor masking agent comprises at least one of peppermint oil, spearmint oil, eucalyptus oil, cinnamon oil, lemon oil or vanilla extract;

[0023] and / or,

[0024] the antibacterial agent comprises at least one of nisin, lysozyme, glucose oxidase, ε-polylysine or chlorhexidine.

[0025] Preferably, the denture adhesive further comprises at least one of antibacterial drugs, anti-inflammatory drugs or analgesic drugs.

[0026] More preferably, the denture adhesive comprises the following components by mass percentage:

[0027]

[0028]

[0029] Compared with the prior art, the beneficial effects of the present application are as follows:

[0030] The denture adhesive of the present application uses a water-insoluble gum base as the main adhesion component, which is insoluble in saliva, can provide an adhesion time far exceeding that of traditional water-soluble adhesives, effectively maintain the retention force of the denture, and reduce the frequency of patients replacing the adhesive.

[0031] The denture adhesive of the present application has good fluidity in the initial stage of use and can fully fill the gap between the denture and oral tissues. As the solvent slowly volatilizes, the gum base gradually solidifies, and a soft buffer layer similar to a denture soft liner can be formed between the denture and oral tissues, effectively relieving the pressure pain points and reducing the frequency of patients replacing the soft liner material.

[0032] The components of the denture adhesive of the present application are non-toxic and harmless to the human body. Even if a small amount is accidentally ingested, it will not cause serious harm to health, greatly improving the safety of the product, especially suitable for elderly patients. Detailed implementation manners

[0033] The technical solutions in the embodiments of the present application will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present application.

[0034] In the following description of this embodiment, the terms "including", "comprising", "having" and "containing" are all open-ended terms, that is, they are meant to include but not limited to.

[0035] In the following description of this embodiment, the term "and / or" is used to describe the association relationship of associated objects, indicating that three relationships can exist. For example, A and / or B can represent: A exists alone, B exists alone, and both A and B exist simultaneously. Where A and B can be singular or plural. The character " / " generally represents that the associated objects before and after are an "or" relationship.

[0036] In the following description of this embodiment, the term "at least one" means one or more, and "multiple" means two or more. "At least one of the following items (pieces)" or its similar expressions refer to any combination of these items, including any combination of single item (piece) or plural items (pieces). For example, "at least one of a, b or c", or, "at least one of a, b and c" can both represent: a, b, c, a-b (that is, a and b), a-c, b-c, or a-b-c, where a, b, c can be single or multiple respectively.

[0037] The terms used in the embodiments of the present application are for the purpose of describing specific embodiments only and are not intended to limit the present application. The singular forms "a" and "the" used in the embodiments of the present application and the appended claims are also intended to include the plural forms unless the context clearly dictates otherwise.

[0038] Those skilled in the art should understand that in the following description of the embodiments of the present application, the sequence numbers do not imply the order of execution, and some or all of the steps can be executed in parallel or sequentially. The execution order of each process should be determined by its function and internal logic, and should not constitute any limitation to the implementation process of the embodiments of the present application.

[0039] Those skilled in the art should understand that the numerical ranges in the embodiments of the present application should be understood as specifically disclosing each intermediate value between the upper and lower limits of the range. Each intermediate value within any stated value or stated range, as well as each smaller range between any other stated value or intermediate value within the stated range, is also included in the present application. The upper and lower limits of these smaller ranges can be independently included or excluded from the range.

[0040] Unless otherwise specified, the technical / scientific terms used herein have the same meaning as commonly understood by those of ordinary skill in the art to which this application belongs. Although this application only describes preferred methods and materials, any methods and materials similar or equivalent to those described herein can also be used in the implementation or testing of this application. All documents mentioned in this specification are incorporated by reference to disclose and describe the methods and / or materials related to the documents. In case of conflict with any incorporated document, the content of this specification shall prevail.

[0041] The present application provides a denture adhesive with long-lasting adhesion and soft lining functions, which includes the following components in mass percentage:

[0042]

[0043]

[0044] The balance is an organic solvent.

[0045] In the denture adhesive of the present application, the gum base is the main adhesive component of the denture adhesive, making the denture adhesive have good adhesive performance and durability. The gum base is selected from any one or a mixture of two or more of polyvinyl acetate, butyl rubber, polyisobutene, ethylene vinyl acetate copolymer, natural gum, plant wax or microcrystalline wax, preferably polyvinyl acetate or polyisobutene. The softening point of the gum base is 20 - 120 °C.

[0046] The organic solvent is used to dissolve the gum base, enabling the denture adhesive to have good fluidity in the initial stage of use and being able to fully fill the gap between the denture and oral tissues. The solvent is selected from any one or a mixture of two or more of ethanol, isopropanol, propylene glycol, glycerol, ethyl acetate, triethyl acetate or ethyl lactate, and ethanol is preferred.

[0047] The filler is used to adjust the rheological properties and mechanical strength of the denture adhesive. In this application, the filler is selected from any one or a mixture of two or more of silica, calcium phosphate, calcium carbonate, hydroxyapatite, microcrystalline cellulose or zinc oxide, and microcrystalline cellulose or zinc oxide is preferred.

[0048] The plasticizer is used to adjust the softness and elasticity of the denture adhesive, enabling it to provide a comfortable soft lining effect during use. The plasticizer is selected from any one or a mixture of two or more of triethyl citrate, acetyl tributyl citrate, triacetin, propylene glycol, polyethylene glycol or sorbitol, and acetyl tributyl citrate is preferred.

[0049] The antioxidant is used to prevent the denture adhesive from undergoing an oxidation reaction during use and to extend its service life. The antioxidant is selected from any one or a mixture of two or more of vitamin E (tocopherol), vitamin C (ascorbic acid), rosemary extract or tea polyphenols, and vitamin E is preferred.

[0050] The colorant is used to make the color of the denture adhesive close to the natural gum color and improve aesthetics. The colorant is selected from any one or a mixture of two or more of carmine, betanin, curcumin, carotene, titanium dioxide, iron oxide red or iron oxide yellow, and iron oxide red, titanium dioxide or a mixture of the two is preferred.

[0051] The sweetener is used to improve the taste of the denture adhesive and enhance the comfort of use for patients. The sweetener is selected from any one or a mixture of two or more of xylitol, sorbitol, maltitol, isomaltulose, aspartame, sucralose or acesulfame potassium, and a mixture of xylitol and sucralose is preferred.

[0052] The flavor masking agent is used to mask the unpleasant odor of certain components in the denture adhesive and improve the user experience of patients. The flavor masking agent is selected from any one or a mixture of two or more of peppermint oil, spearmint oil, eucalyptus oil, cinnamon oil, lemon oil or vanilla extract, and peppermint oil is preferred.

[0053] The antibacterial agent is used to inhibit the growth of oral bacteria and maintain oral health. The antibacterial agent is selected from any one or a mixture of two or more of nisin, lysozyme, glucose oxidase, ε-polylysine or chlorhexidine and its salts, and nisin or chlorhexidine is preferred.

[0054] In this application, antibacterial drugs, anti-inflammatory drugs, painkillers, etc. can also be added to the denture adhesive for local drug sustained release in the oral cavity.

[0055] The denture adhesive of this application uses a water-insoluble gum base as the main adhesive component, which is insoluble in saliva, can provide an adhesion time far exceeding that of traditional water-soluble adhesives, effectively maintain the retention force of the denture, and reduce the frequency of patients replacing the adhesive. At the same time, the denture adhesive has good fluidity in the initial stage of use, can fully fill the gap between the denture and oral tissues. As the solvent slowly volatilizes, the gum base gradually solidifies, and a soft buffer layer similar to a denture soft liner can be formed between the denture and oral tissues, effectively relieving the pain points and reducing the frequency of patients replacing the soft liner material. In addition, the components of the denture adhesive are non-toxic and harmless to the human body, and even if a small amount is accidentally ingested, it will not cause serious harm to health, greatly improving the safety of the product, especially suitable for elderly patients.

[0056] The denture adhesive of this application is easy to use. Before use, no special treatment is required. Just apply it on the denture base and then insert the denture into the oral cavity. Patients can operate by themselves without the guidance of a professional doctor. In addition, the denture adhesive of this application has a good taste and comfort, and has antibacterial and anti-inflammatory effects.

[0057] As a preferred embodiment of this application, the denture adhesive, by mass percentage, comprises the following components:

[0058]

[0059] The balance is an organic solvent.

[0060] As a more preferred embodiment of this application, the denture adhesive, by mass percentage, comprises the following components:

[0061]

[0062] The denture adhesive of this application is prepared by the following method:

[0063] S1, pulverize the gum base into powder; by pulverizing, increase its contact area with the solvent and shorten the dissolution time.

[0064] S2, mix the solvent, plasticizer, colorant, sweetener, flavor masking agent, antibacterial agent and antioxidant in proportion and stir evenly to form a uniform mixed solution;

[0065] S3, slowly add the pulverized gum base to the mixed solution and use a kneader or planetary mixer for sufficient mixing. Among them, control the mixing temperature above the softening point of the gum base to promote the dissolution and uniform dispersion of the gum base.

[0066] S4. After the gum base is completely dissolved, slowly add the filler and continue stirring to evenly disperse the filler in the mixture.

[0067] S5. Transfer the mixture to a degassing tank and perform degassing treatment by centrifugation or under vacuum to remove the bubbles in the mixture while preventing the removal of the solvent.

[0068] S6. Perform shaping treatment on the degassed mixture, such as extruding it into strips, pressing it into sheets, or filling it into a packaging container and sealing the package to prevent the volatilization of the solvent and microbial contamination.

[0069] The present application will be further described below through examples.

[0070] Example 1

[0071] Crush 62 g of polyvinyl acetate to a particle size less than 1 mm; mix 37 g of ethanol and 0.3 g of vitamin E and stir evenly to form a mixed solution.

[0072] Slowly add the crushed polyvinyl acetate to the mixed solution and knead it in a kneader, controlling the temperature at 80 °C. After the polyvinyl acetate is completely dissolved, add 0.7 g of zinc oxide and continue kneading to make it evenly dispersed; then transfer it to a centrifugal degassing tank and perform centrifugal degassing treatment for 30 minutes to obtain a denture adhesive. Fill the denture adhesive into an aluminum-plastic composite tube for individual packaging.

[0073] Example 2

[0074] Crush 78 g of polyvinyl acetate to a particle size less than 1 mm; mix 16.17 g of ethanol, 5 g of glycerol, 0.03 g of beet red, 0.1 g of sucralose, and 0.2 g of peppermint oil and stir evenly to form a mixed solution.

[0075] Slowly add the crushed polyvinyl acetate to the mixed solution and knead it in a kneader, controlling the temperature at 50 °C; after the polyvinyl acetate is completely dissolved, add 0.5 g of magnesium oxide and continue kneading to make it evenly dispersed; then transfer it to a centrifugal degassing tank and perform centrifugal degassing treatment for 15 minutes to obtain a denture adhesive. Fill the denture adhesive into an aluminum-plastic composite tube for individual packaging.

[0076] Example 3

[0077] Mix 13 g of ethyl acetate, 10 g of triethyl citrate, 0.02 g of yellow iron oxide, 0.08 g of aspartame, 0.3 g of spearmint oil and 0.6 g of vitamin C, stir evenly, and heat to 40 °C to accelerate dissolution; slowly add 75 g of polyisobutene to the mixed solution, stir in a planetary mixer, and control the temperature at 90 °C; after the polyisobutene is completely dissolved, add 1.0 g of hydroxyapatite, continue to stir to make it evenly dispersed; then transfer it to a vacuum degassing tank and perform degassing treatment for 5 minutes under a vacuum of 0.085 MPa to obtain a denture adhesive. Fill the denture adhesive into an aluminum-plastic composite tube for individual packaging.

[0078] Example 4

[0079] Crush 80 g of polyvinyl acetate to a particle size of less than 1 mm; mix 5 g of ethanol, 5 g of ethyl acetate, 5 g of tributyl acetylcitrate, 0.1 g of iron oxide red, 0.05 g of titanium dioxide, 0.2 g of sucralose, 0.3 g of peppermint oil, 0.05 g of nisin and 0.3 g of vitamin E, stir evenly to form a mixed solution.

[0080] Slowly add the crushed polyvinyl acetate to the mixed solution, knead in a kneader, and control the temperature at 80 °C; after the polyvinyl acetate is completely dissolved, add 4 g of microcrystalline cellulose, continue to knead to make it evenly dispersed; then transfer it to a vacuum degassing tank and perform degassing treatment for 25 minutes under a vacuum of 0.09 MPa to obtain a denture adhesive. Fill the denture adhesive into an aluminum-plastic composite tube for individual packaging.

[0081] Example 5

[0082] Crush 55 g of natural gum to a particle size of less than 1 mm; mix 15 g of isopropyl alcohol, 10 g of glycerol, 15 g of triethyl citrate, 0.08 g of curcumin, 0.15 g of aspartame, 0.4 g of spearmint oil, 0.1 g of lysozyme and 0.2 g of vitamin C, stir evenly and heat to 40 °C to form a mixed solution.

[0083] Slowly add the crushed natural gum to the mixed solution, stir in a planetary mixer, and control the temperature at 90 °C. After the natural gum is completely dissolved, add 4.02 g of calcium phosphate, continue to stir to make it evenly dispersed; then transfer it to a vacuum degassing tank and perform degassing treatment for 20 minutes under a vacuum of 0.085 MPa to obtain a denture adhesive. Fill the denture adhesive into an aluminum-plastic composite tube for individual packaging.

[0084] Example 6

[0085] Crush 40 g of butyl rubber and 20 g of polyvinyl acetate to a particle size of less than 1 mm respectively; mix 10 g of triethyl acetate, 10 g of propylene glycol, 15 g of tributyl acetylcitrate, 0.05 g of carmine, 0.3 g of xylitol, 0.2 g of eucalyptus oil, 0.1 g of glucose oxidase and 0.3 g of rosemary extract, and stir evenly to form a mixed solution.

[0086] Slowly add the crushed butyl rubber and polyvinyl acetate to the mixed solution, knead in a kneader, and control the temperature at 100 °C; after the gum base is completely dissolved, add 4 g of calcium carbonate, continue to knead to make it evenly dispersed; then transfer it to a centrifugal degassing tank for centrifugal degassing treatment for 18 minutes to obtain a denture adhesive. Fill the denture adhesive into an aluminum-plastic composite tube for individual packaging.

[0087] Perform performance tests on the denture adhesives prepared in Examples 1-6 as follows:

[0088] (1) Adhesion strength test

[0089] Refer to the YY / T 1280-2015 Dentistry Denture Adhesive Standard and use a universal testing machine for testing. Use a commercially available similar product as a control group, and the test results are shown in Table 1.

[0090] Among them, the commercially available similar product selected is a denture stabilizer with the trade name Poligrip, produced by Steradent Miller (Ireland) Limited.

[0091] Table 1 Adhesion strength test data of denture adhesives

[0092]

[0093] From the test results in Table 1, it can be seen that the denture adhesives prepared in the examples of this application have an initial adhesion strength higher than 39 KPa; the adhesion strength is still higher than 35 KPa after being immersed in artificial saliva for 96 hours, and the adhesion strength is significantly better than that of commercially available similar products. The denture adhesive prepared in Example 4 has the highest initial adhesion strength, and its adhesion strength is still the highest after being immersed in artificial saliva for 96 hours.

[0094] (2) Biocompatibility test

[0095] Adopt cytotoxicity test and animal experiment to evaluate the biocompatibility of the denture adhesive. Among them, the cytotoxicity test adopts the method of GB / T16886.5-2017 Part 5: In vitro cytotoxicity test, and the animal experiment evaluation adopts the method of YY / T_0127.13-2018 Biological evaluation of oral medical devices Part 13: Oral mucosal irritation test. The test results are shown in Table 2.

[0096] Table 2 Cytotoxicity test results of denture adhesives

[0097] Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Control group Cytotoxicity (grade) 0-1 0-1 0-1 0-1 0-1 0-1 0-1

[0098] The test results show that the denture adhesives prepared in this application do not exhibit obvious cytotoxicity; the test results of animal experiments show that they are non-irritating to oral mucosa and have good biocompatibility.

[0099] The denture adhesives prepared in this application were clinically trialed, and this clinical trial has obtained the approval of the ethics committee.

[0100] Trial subjects: 30 complete or partial denture wearers were selected, with an age range of 20 - 70 years old and a male-female ratio of 1:1. Patients with severe oral diseases or allergic to the components of the denture adhesive were excluded, and they voluntarily participated in this clinical trial.

[0101] Trial period: The trial period was 30 days. During this period, the participants used the denture adhesives of the present invention and recorded their usage experiences.

[0102] Trial samples: The denture adhesive of Example 4 and a commercially available product (Poligrip Denture Adhesive, Steradent-Miller (Ireland) Limited).

[0103] Evaluation indicators and evaluation results:

[0104] Adhesion situation: The denture adhesive was applied on the denture base and then inserted into the oral cavity, and the time for maintaining the adhesion effect after use was recorded. The denture adhesive of Example 4 could still maintain the adhesion strength after 96 hours and was then manually removed. The commercially available product basically lost its adhesion strength after 24 hours.

[0105] Soft lining effect: The soft lining effect was evaluated by the patients' perception of the hardness of the denture adhesive. The denture adhesive of Example 4 had a relatively low initial hardness, providing a good soft lining effect; as time passed, the hardness gradually increased, but it could still maintain a certain elasticity within 96 hours of wearing, providing a buffering effect; in contrast, the commercially available product had no soft lining effect.

[0106] The wearing comfort was evaluated through a questionnaire survey, as follows:

[0107] Relief of tenderness: 98 ± 7% of the participants using the denture adhesive of Example 4 indicated that the tenderness was significantly relieved. The commercially available product had no effect on relieving tenderness.

[0108] Taste: 95 ± 10% of the participants using the denture adhesive of Example 4 indicated that the taste was good and there was no obvious discomfort; 94 ± 8% of the participants using the commercially available product indicated that the taste was good and there was no obvious discomfort.

[0109] Odor: 93 ± 8% of the participants using the denture adhesive of Example 4 reported a fresh odor with no obvious unpleasant smell. 92 ± 9% of the participants using the commercial product reported a good taste with no obvious discomfort.

[0110] Biocompatibility: The biocompatibility was evaluated by observing the reaction of the oral mucosa during the trial period. Macroscopically, no obvious oral mucosal irritation or allergic reaction occurred in all participants using the denture adhesive of Example 4 and the commercial product, indicating good biocompatibility.

[0111] The above data show that the denture adhesive of the present invention exhibits excellent performance in terms of adhesion strength, adhesion time, soft lining effect, comfort, and biocompatibility. Compared with the commercial product, the long-term adhesion strength and soft lining effect of the denture adhesive of the present invention have significant advantages, which can significantly improve the use experience of denture wearers.

[0112] Although the present application has been described in detail with general descriptions and specific embodiments in this specification, some modifications or improvements can be made based on the present application, which are obvious to those skilled in the art. Therefore, these modifications or improvements made without departing from the spirit of the present application fall within the scope of protection required by the present application.

Claims

1. A denture adhesive with long-acting adhesion and soft lining functions, characterized in that, Comprising the following components by mass percentage: Gum base 20 - 95 wt% Filler 0 - 20 wt% Plasticizer 0 - 20 wt% Antioxidant 0 - 1 wt% Colorant 0 - 2 wt% Sweetener 0 - 3 wt% Flavor masking agent 0 - 2 wt% Antibacterial agent 0 - 3.0 wt% The balance is organic solvent.

2. The denture adhesive according to claim 1, wherein Comprising the following components by mass percentage: Gum base 20 - 95 wt% Filler 0.05 - 20 wt% Plasticizer 0.1 - 20 wt% Antioxidant 0.01 - 1 wt% Colorant 0.01 - 2 wt% Sweetener 0.1 - 3 wt% Flavor masking agent 0.05 - 2 wt% Antibacterial agent 0.02 - 3.0 wt% The balance is organic solvent.

3. The denture adhesive according to claim 1, wherein The gum base includes at least one of polyvinyl acetate, butyl rubber, polyisobutene, ethylene-vinyl acetate copolymer, natural gum, plant wax or microcrystalline wax.

4. The denture adhesive according to claim 1, characterized in that, The plasticizer includes at least one of triethyl citrate, tributyl acetylcitrate, triacetin, propylene glycol, polyethylene glycol or sorbitol.

5. The denture adhesive according to claim 1, characterized in that, The antioxidant includes at least one of vitamin E, ascorbic acid, rosemary extract or tea polyphenols.

6. The denture adhesive according to claim 1, characterized in that, The filler includes at least one of silica, calcium phosphate, calcium carbonate, hydroxyapatite, microcrystalline cellulose or zinc oxide.

7. The denture adhesive according to claim 1, wherein The organic solvent includes at least one of ethanol, isopropanol, propylene glycol, glycerol, ethyl acetate, triethyl acetate or ethyl lactate.

8. The denture adhesive according to claim 1, characterized in that, The colorant includes at least one of carmine, betanin, curcumin, carotene, titanium dioxide, iron oxide red or iron oxide yellow; And / or, The sweetener includes at least one of xylitol, sorbitol, maltitol, isomalt, aspartame, sucralose or acesulfame potassium; And / or, The flavor masking agent includes at least one of peppermint oil, spearmint oil, eucalyptus oil, cinnamon oil, lemon oil or vanilla extract; And / or, The antibacterial agent includes at least one of nisin, lysozyme, glucose oxidase, ε-polylysine or chlorhexidine.

9. The denture adhesive according to claim 1, wherein It further includes at least one of antibacterial drugs, anti-inflammatory drugs or analgesic drugs.

10. The denture adhesive according to claim 2, characterized in that, Comprising the following components by mass percentage: Polyvinyl acetate 80 wt%

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