Novel preparation method of cedar seed heart-nourishing tablet

Abstract

The invention discloses a novel preparation method of a cedar seed heart-nourishing tablet, and belongs to the field of medicines.The preparation method comprises the steps that extract is dried in a mode of organically combining vacuum drying and vacuum microwave drying, dry extract with viscosity removed, ferulic acid content improved and qualified mercuric sulfide content guaranteed is obtained, and forming and content of the cedar seed heart-nourishing tablet are guaranteed; and meanwhile, the process parameters are clear, the production process quality is controllable, the production period is greatly shortened, the labor cost and the energy cost are reduced, and the application value is very high.

Description

Technical Field

[0001] The present invention relates to the field of pharmaceutical technology, and particularly relates to a new method for preparing Baizi Yangxin Tablets. Background Art

[0002] Baizi Yangxin Tablets is a common Chinese patent medicine, which has the effects of replenishing qi, nourishing blood, and calming the mind, and is mainly used for treating heart qi deficiency and cold, palpitations and easy startle, insomnia and dreaminess, and amnesia. The current implementation standard of Baizi Yangxin Tablets is the first part of the Chinese Pharmacopoeia 2020 Edition P1254 (hereinafter referred to as the "current national standard" for short), and its preparation method is as follows: 32 g of cinnamon, 32 g of Codonopsis pilosula, and 90 g of Pinellia ternata (processed with bran) are pulverized into fine powder; 38 g of cinnabar is levigated into extremely fine powder with water; 128 g of Angelica sinensis, 128 g of Ligusticum wallichii, and 32 g of Platycladus orientalis seeds are used as solvents with 70% ethanol, impregnated for 24 hours, percolated, and about 1500 ml of percolate is collected, and the ethanol is recovered; 32 g of Schisandra chinensis (processed with vinegar) and 32 g of Polygala tenuifolia (processed with honey) are used as solvents with 60% ethanol, impregnated for 24 hours, percolated, and about 320 ml of percolate is collected, and the ethanol is recovered; the remaining 38 g of Pinellia ternata (processed with bran) and the above two kinds of medicinal residues after percolation, together with 128 g of Astragalus membranaceus (processed with honey), 13 g of Glycyrrhiza uralensis (processed with honey), 256 g of Poria cocos, and 32 g of Ziziphus jujuba var. spinosa are decocted twice with water for 2 hours each time, and the decoction is filtered. The percolates are combined, combined with the above-mentioned medicinal liquids, concentrated to an appropriate amount, added with the fine powder of cinnamon, Codonopsis pilosula, and Pinellia ternata (processed with bran), mixed evenly, dried, ground finely, then added with the extremely fine powder of cinnabar, mixed evenly, granulated, dried, pressed into 1000 tablets, and sugar-coated to obtain the product.

[0003] In the drying process of the extract in the production process of the current national standard Baizi Yangxin Tablets, generally one of vacuum drying or vacuum microwave drying is used in the industry. However, due to the special nature of the Baizi Yangxin Tablets material, problems exist in using any one of the drying methods, and the main problems are as follows: (1) If the extract is dried with a vacuum dryer, the drying time of the extract is long (about 900 minutes), and the temperature is high, resulting in excessive loss of the active ingredient ferulic acid, and the transfer rate of ferulic acid is only 2-3%, which cannot meet the expected quality of Baizi Yangxin Tablets; the results are shown in Table 1: (2) When the extract is dried with a vacuum microwave dryer, the drying time of the extract is short (about 80 minutes), and the temperature is low, and the active ingredient ferulic acid can be retained to a large extent, and the transfer rate of ferulic acid is greater than or equal to 30%. However, the dry extract is prone to moisture absorption and has too strong viscosity, making it difficult to be pulverized alone in a pulverizing device, and the extract powder has extremely poor formability during the preparation process, as Figure 1 and Figure 2 shown; (3) After drying with a vacuum microwave dryer, the amount of dry extract is large, resulting in an increase in the amount of prepared preparations, an increase in the dosage of the preparation, and a decrease in the active ingredients per unit preparation. According to the requirements of the Coptis Chinensis Standard in the 2020 edition of the Chinese Pharmacopoeia, the dosage of cinnabar in each prescription is 38 g. Cinnabar contains 96%-100% mercury sulfide and is made into 1000 tablets. The amount of cinnabar per tablet, calculated as mercury sulfide (HgS), should be 30.0-38.0 mg. That is, each tablet of Coptis Chinensis contains 0.038 g of cinnabar. If the dosage of the preparation increases, the amount of cinnabar per tablet will decrease, resulting in the unqualified mercury sulfide content of Coptis Chinensis, as shown in Table 2: (4) The vacuum dryer has high energy consumption, using 40 kg of steam per hour at 300 yuan per ton and 5 kWh of electricity per hour at 0.7 yuan per kWh. The drying cost is: 40 kg / hour × 15 hours (900 minutes) ÷ 1000 × 300 yuan / ton + 5 kWh / hour × 15 hours × 0.7 yuan / kWh = 232.5 yuan. The vacuum microwave dryer has low energy consumption, only consuming 30 kWh of electricity per hour, 30 kWh / hour × 1.3 hours × 0.7 yuan / kWh = 27.3 yuan.

[0004] Table 1 Ferulic acid content transfer rate of extracts dried by different methods in the prior art ,

[0005] Table 2 Dry extract weight of extracts dried by different methods in the prior art . Summary of the Invention

[0006] The object of the present invention is to provide a new method for preparing Coptis Chinensis tablets to solve the above problems.

[0007] To achieve the above object, the technical solution adopted by the present invention is as follows: A new method for preparing Coptis Chinensis tablets includes the following steps: (1) Cinnamon, Codonopsis pilosula, part of Pinellia ternata, cinnabar, Angelica sinensis, Ligusticum wallichii, and Platycladus orientalis are percolated, the percolate is collected, and ethanol is recovered; (2) Schisandra chinensis and Polygala tenuifolia are percolated with vinegar, the percolate is collected, and ethanol is recovered; (3) The remaining Pinellia ternata and the dregs of the above two percolated herbs are decocted with Astragalus membranaceus, Glycyrrhiza glabra, Poria cocos, and Ziziphus jujuba var. spinosa, the decoction is filtered, and the percolate is combined; (4) The medicinal liquids in steps (1), (2), and (3) are combined, concentrated, and fine powder of cinnamon, Codonopsis pilosula, and Pinellia ternata are added and mixed evenly to obtain the material to be dried; (5) For the material to be dried obtained in step (4), 40wt% - 50wt% is dried by microwave vacuum drying, and the remaining material is dried by vacuum drying to obtain dry extracts respectively, which are mixed and pulverized to obtain extract powder; (6) Granulate the extract powder, cinnabar, syrup, and ethanol obtained in step (5) to obtain the product.

[0008] In the above method steps of the present invention, the processes before the extract drying are the same as those of the prior art. The present invention mainly improves the extract drying method and the preparation forming.

[0009] The inventors of the present application found during the experiment that: when the medicinal materials are extracted and concentrated to obtain an extract and the extract is dried: If the entire extract is dried by mixing paste in a vacuum drying tank and the extract powder is obtained after pulverization, the content transfer rate of the extract powder (ferulic acid) is extremely low and the content of (ferulic acid) is unqualified; even if the temperature and vacuum degree are adjusted and dried in a vacuum drying tank, the content transfer rate of (ferulic acid) is still extremely low and the content of (ferulic acid) is unqualified; Then, try to change the drying method, that is, use vacuum microwave drying for all. The content transfer rate of (ferulic acid) is significantly increased and the content of (ferulic acid) is qualified. However, the weight of the extract powder increases and the viscosity is extremely strong. It is extremely difficult to granulate the extract powder even with ethanol with strong wettability, and the content of (mercuric sulfide) is unqualified; Optimize the drying method: By calculating the weight of the mixture required for the qualified finished product content, take 40wt% - 50wt% of the extract for vacuum microwave drying, and the remaining extract for vacuum drying. The content of (ferulic acid) is qualified, and the weight and viscosity of the extract powder are both reduced; Next, in the granulation step, try granulating with water. Although the content of (mercuric sulfide) is qualified, particle dropping occurs during tabletting. Therefore, try granulating with syrup. The concentration of the syrup is adjusted according to the water content and viscosity of the extract. For example, granulate with 73wt% syrup, the content of (mercuric sulfide) is qualified, and the forming property of the plain tablets is good.

[0010] In addition, regarding mercuric sulfide, if the extract is dried in a vacuum drying tank, the obtained dry extract is pulverized and made into a finished product, and the finished product yield is about 96.74%, and the content of (mercuric sulfide) is qualified; if the extract is dried in a vacuum microwave drying tank, the obtained dry extract is pulverized and made into a finished product, and the finished product yield is about 117.47%, and the content of (mercuric sulfide) is unqualified.

[0011] As a preferred technical solution, in step (5), the method of microwave vacuum drying is as follows: Load the extract into the baking tray of the microwave vacuum dryer evenly at 2.0 - 4.0 kg / tray, set the temperature at 45 - 55 °C, the vacuum degree ≤ 0.08 Mpa, and the time at 75 - 90 min.

[0012] If the loading amount per tray < 2 kg, the material is prone to coking due to being too thin; if the loading amount per tray > 4 kg, the material is prone to overflowing from the stainless steel tray due to excessive expansion.

[0013] As a further preferred technical solution, the set temperature is 50 °C.

[0014] As a preferred technical solution, in step (5), the method of vacuum drying is as follows: the extract is evenly loaded into the drying trays of a vacuum drying oven at 2.0 - 4.0 kg / tray, the temperature is set at 60 - 80°C, the vacuum degree is ≤ 0.08 Mpa, and the time is 14 - 16 h.

[0015] As a further preferred technical solution, the vacuum drying temperature is 70°C.

[0016] As a preferred technical solution, in step (5), the water contents of the dry extract after microwave vacuum drying and vacuum drying are both controlled at 4 - 6 wt%. Controlling the water content at 4 - 6 wt% can not only avoid excessive loss of ferulic acid content during the drying process due to too high water content of the material, but also avoid coking of the material due to too low water content.

[0017] As a preferred technical solution, 73 wt% syrup is used during the preparation of the preparation, and the mass ratio of the material to the 73 wt% syrup is 10:(0.5% - 2.5%), which can not only increase the granulation formability of the particles but also greatly improve the surface properties of the plain tablets.

[0018] In order to solve the above problems, through a large amount of theoretical analysis and combined with a large number of experiments, the inventor adopted a new preparation method, which can not only effectively increase the ferulic acid content in the extract, but also reduce the viscosity of the dry extract, solve the problem of poor formability of Baizi Yangxin tablets, reduce energy consumption, lower costs, and at the same time ensure that the mercury sulfide content of Baizi Yangxin tablets is qualified, greatly improving the product quality of Baizi Yangxin tablets.

[0019] Compared with the prior art, the advantages of the present invention are as follows: the present invention dries the extract by an organic combination of vacuum drying and vacuum microwave drying, obtaining a dry extract that removes viscosity, improves the ferulic acid content and ensures the qualified mercury sulfide content, ensuring the formation and content of Baizi Yangxin tablets; at the same time, the process parameters are clear, the quality of the production process is controllable, the production cycle is greatly shortened, the labor cost and energy cost are reduced, and it has high application value. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is a photo of the extract powder after drying the extract using a vacuum microwave dryer in the prior art; Figure 2 It is a photo of the formation of plain tablets after drying the extract using a vacuum microwave dryer in the prior art; Figure 3 It is a photo of the formation of plain tablets after drying the extract in Example 1 of the present invention; Figure 4 It is a photo of the formation of plain tablets after drying the extract in Example 2 of the present invention; Figure 5 It is a photo of the formation of plain tablets after drying the extract in Example 3 of the present invention; Figure 6Photograph of the plain tablets formed after drying the extract for Comparative Example 1 of the present invention; Figure 7 Photograph of the plain tablets formed after drying the extract for Comparative Example 2 of the present invention; Figure 8 Photograph of the plain tablets formed after drying the extract for Comparative Example 3 of the present invention. Detailed implementation manners

[0021] The present invention will be further described below in conjunction with the embodiments.

[0022] In the following embodiments and comparative examples, unless otherwise specified, the ethanol concentration used refers to volume percentage concentration; for the rest of the percentages, unless otherwise specified, they refer to mass percentages.

[0023] Example 1 A new method for preparing Baizi Yangxin Tablets includes the following steps: 32 g of cinnamon, 32 g of Codonopsis pilosula, and 90 g of Pinellia ternata prepared with six drugs are pulverized into fine powder; 38 g of cinnabar is levigated into extremely fine powder; 128 g of Angelica sinensis, 128 g of Ligusticum chuanxiong, and 32 g of Platycladus orientalis seeds are soaked with 70% ethanol as the solvent for 24 hours, then percolated, and 1500 ml of percolate is collected, and the ethanol is recovered; 32 g of Schisandra chinensis vinegar-processed and 32 g of Polygala tenuifolia processed are soaked with 60% ethanol as the solvent for 24 hours, then percolated, and 320 ml of percolate is collected, and the ethanol is recovered; the remaining 38 g of Pinellia ternata and the two kinds of drug residues after percolation above are decocted twice with 128 g of Astragalus membranaceus processed with honey, 13 g of Glycyrrhiza uralensis processed with honey, 256 g of Poria cocos, and 32 g of Ziziphus jujuba var. spinosa for 2 hours each time, and the decoction is filtered; the percolates are combined, and combined with the above-mentioned various medicinal liquids, concentrated to a density of 1.143 (60 °C), with a weight of 398 g; the fine powder of cinnamon, Codonopsis pilosula, and Pinellia ternata is added, mixed evenly, and the mixed material is divided into two parts, which are dried separately using a vacuum dryer and a vacuum microwave dryer. When drying, the material needs to be evenly spread on a stainless steel plate, 3 kg / plate; the stainless steel plate containing 50% of the extract material is sent into the vacuum dryer for drying, the temperature of the vacuum dryer is set at 70 °C, and the vacuum degree ≤ 0.04 Mpa (slowly increase the vacuum degree to 0.08 Mpa) to control the water content of the dry extract at about 5%; the stainless steel plate containing the remaining 50% of the extract material is sent into the vacuum microwave dryer for drying, the temperature of the vacuum microwave dryer is set at 50 °C, and the vacuum degree ≤ 0.04 Mpa. After 40 minutes, the vacuum degree is adjusted to 0.08 Mpa to control the water content of the dry extract at about 5%; the dried dry extract is pulverized and mixed evenly, then the extremely fine powder of cinnabar is added, mixed evenly, according to the state of the material, 26.32 g of 73 wt% syrup is taken, granulated, dried, pressed into 1000 tablets, and sugar-coated to obtain the product. For the specific physical object, see Figure 3 ; The results are shown in Table 3.

[0024] Example 2 A new method for preparing Baizi Yangxin Tablets includes the following steps: 32 g of cinnamon, 32 g of codonopsis pilosula, and 90 g of fermented pinellia tuber are pulverized into fine powder; 38 g of cinnabar is levigated into extremely fine powder; 128 g of angelica sinensis, 128 g of ligusticum wallichii, and 32 g of semen platycladi are used as solvents with 70% ethanol, impregnated for 24 hours, percolated, and about 1500 ml of percolate is collected, and the ethanol is recovered; 32 g of schisandra chinensis vinegar-processed and 32 g of polygala tenuifolia processed are used as solvents with 60% ethanol, impregnated for 24 hours, percolated, and about 320 ml of percolate is collected, and the ethanol is recovered; the remaining 38 g of fermented pinellia tuber and the residues of the above two percolations, together with 128 g of astragalus membranaceus stir-fried with honey, 13 g of glycyrrhiza uralensis stir-fried with honey, 256 g of poria cocos, and 32 g of semen ziziphi spinosae are decocted twice with water, each time for 2 hours, and the decoction is filtered. The percolates are combined, combined with the above various medicinal liquors, concentrated to a density of 1.155 (58 °C) and a weight of 389 g, and the fine powder of cinnamon, codonopsis pilosula, and fermented pinellia tuber is added and mixed evenly. The mixed material is divided into two parts, and vacuum drying and vacuum microwave drying are respectively used. When drying, the material needs to be evenly spread on a stainless steel plate, 2 - 4 kg / plate; the stainless steel plate containing 55% of the extract material is sent into the vacuum dryer for drying, the temperature of the vacuum dryer is set at 70 °C, and the vacuum degree ≤ 0.04 Mpa (slowly increase the vacuum degree to 0.08 Mpa) to control the water content of the dry extract at 4 - 6%; the stainless steel plate containing the remaining 45% of the extract material is sent into the vacuum microwave dryer for drying, the temperature of the vacuum microwave dryer is set at 50 °C, and the vacuum degree ≤ 0.04 Mpa. After 40 minutes, the vacuum degree is adjusted to 0.08 Mpa to control the water content of the dry extract at about 5%. The dry extract after the new drying method is pulverized and mixed evenly, and then the extremely fine powder of cinnabar is added and mixed evenly. According to the state of the material, 29.48 g of 73 wt% syrup is taken, granulated, dried, pressed into 1000 tablets, and sugar-coated to obtain the product. For the specific physical object, see Figure 4 ; The results are shown in Table 3.

[0025] Example 3 A new preparation method of Bozi Yangxin tablets, comprising the following steps: 32 g of cinnamon, 32 g of codonopsis pilosula, and 90 g of fermented pinellia tuber are pulverized into fine powder; 38 g of cinnabar is levigated into extremely fine powder; 128 g of angelica sinensis, 128 g of ligusticum wallichii, and 32 g of semen platycladi are used as solvents with 70% ethanol, impregnated for 24 hours, percolated, and about 1500 ml of percolate is collected, and the ethanol is recovered; 32 g of schisandra chinensis vinegar-processed and 32 g of polygala tenuifolia processed are used as solvents with 60% ethanol, impregnated for 24 hours, percolated, and about 320 ml of percolate is collected, and the ethanol is recovered; the remaining 38 g of fermented pinellia tuber and the residues of the above two percolated medicinal residues are decocted twice with 128 g of astragalus membranaceus roasted, 13 g of glycyrrhiza uralensis roasted, 256 g of poria cocos, and 32 g of semen ziziphi spinosae, each time for 2 hours, and the decoction is filtered. The percolates are combined, combined with the above-mentioned medicinal liquids, concentrated to a density of 1.139 (60 °C) and a weight of 412 g, the fine powder of cinnamon, codonopsis pilosula, and fermented pinellia tuber is added, and mixed evenly. The mixed material is divided into two parts, and dried separately using a vacuum dryer and a vacuum microwave dryer. When drying, the material needs to be evenly spread on a stainless steel tray, 2 - 4 kg / tray; the stainless steel tray containing 60% of the extract material is sent into the vacuum dryer for drying. The temperature of the vacuum dryer is set at 70 °C, and the vacuum degree ≤ 0.04 Mpa (slowly increase the vacuum degree to 0.08 Mpa) to control the water content of the dry extract at 4 - 6%; the stainless steel tray containing the remaining 40% of the extract material is sent into the vacuum microwave dryer for drying. The temperature of the vacuum microwave dryer is set at 50 °C, and the vacuum degree ≤ 0.04 Mpa. After 40 minutes, the vacuum degree is adjusted to 0.08 Mpa to control the water content of the dry extract at about 5%. The dry extract obtained by the new drying method is pulverized and mixed evenly, then the extremely fine powder of cinnabar is added and mixed evenly. According to the state of the material, 32.64 g of 73 wt% syrup is taken, granulated, dried, pressed into 1000 tablets, and sugar-coated to obtain the product. For the specific physical object, see Figure 5 ; The results are shown in Table 3.

[0026] Control Example 1 A method for preparing Baizi Yangxin Tablets, comprising the following steps: 32g of cinnamon bark, 32g of codonopsis pilosula and 90g of pinellia tuber were crushed into fine powder; 38g of cinnabar was pulverized into extremely fine powder with water; 128g of angelica sinensis, 128g of ligusticum chuanxiong and 32g of cypress seed were soaked in 70% ethanol as solvent for 24 hours, and then percolated to collect about 1500ml of percolation liquid to recover ethanol; 32g of vinegar schisandra chinensis and 32g of processed polygala tenuifolia were soaked in 60% ethanol as solvent for 24 hours, and then percolated to collect about 320ml of percolation liquid to recover ethanol; the remaining 38g of pinellia tuber and the above two percolation residues were decocted with 128g of roasted astragalus, 13g of roasted licorice, 256g of poria and 32g of spiny jujube seed in water for two times, each time for 2 hours, and the decoction was filtered. The filtered liquid is combined with the above-mentioned liquids, and concentrated to a density of 1.143 (60°C) and a weight of 409g. Cinnamon bark, Codonopsis pilosula and Pinellia tuber powder are added and mixed. The mixed materials are all dried in a vacuum dryer. When drying, the materials need to be evenly spread in a stainless steel plate, 3kg / plate, and the stainless steel plate containing the materials is sent to a vacuum dryer for drying. The temperature of the vacuum dryer is set to 70°C and the vacuum degree is ≦0.04Mpa (the vacuum degree is slowly increased to 0.08Mpa), so that the moisture content of the dry extract is controlled at 4-6%; the dry extract is crushed and mixed evenly, and then cinnabar powder is added, mixed evenly, 73wt% syrup 55g is added, granulated, dried, pressed into 1000 tablets, and coated with sugar, and the specific physical object is shown in Figure 6 ; The results are shown in Table 3.

[0027] Comparative Example 2 A method for preparing Baizi Yangxin Tablets comprises the following steps: 32 g of cinnamon, 32 g of Codonopsis pilosula, and 90 g of fermented Pinellia ternata are pulverized into fine powder; 38 g of cinnabar is levigated into extremely fine powder; 128 g of Angelica sinensis, 128 g of Ligusticum wallichii, and 32 g of Semen platycladi are taken, using 70% ethanol as a solvent, impregnated for 24 hours, and then percolated. About 1500 ml of percolate is collected, and the ethanol is recovered; 32 g of Schisandra chinensis vinegar-processed and 32 g of Polygala tenuifolia processed are taken, using 60% ethanol as a solvent, impregnated for 24 hours, and then percolated. About 320 ml of percolate is collected, and the ethanol is recovered; the remaining 38 g of fermented Pinellia ternata and the two kinds of residues after percolation above are decocted twice with 128 g of Astragalus membranaceus roasted, 13 g of Glycyrrhiza uralensis roasted, 256 g of Poria cocos, and 32 g of Semen ziziphi spinosae for 2 hours each time, and the decoction is filtered. The percolates are combined, combined with the above-mentioned various medicinal liquids, concentrated to a density of 1.151 (58 °C) and a weight of 392 g, the fine powder of cinnamon, Codonopsis pilosula, and fermented Pinellia ternata is added, and mixed evenly. All the mixed materials are dried by a vacuum microwave dryer. When drying, the materials need to be evenly spread on a stainless steel tray, 2 - 4 kg / tray. The stainless steel tray filled with the materials is sent into the vacuum microwave dryer for drying. The temperature of the vacuum microwave dryer is set at 50 °C, and the vacuum degree ≤ 0.04 Mpa. After 40 minutes, the vacuum degree is adjusted to 0.08 Mpa to control the water content of the dry extract to be 4 - 6%. The dry extract is pulverized and mixed evenly, then the extremely fine powder of cinnabar is added and mixed evenly. According to the state of the materials, 30 g of ethanol is added for granulation, dried, pressed into 1000 tablets, and sugar-coated to obtain the product. For the specific physical object, see Figure 7 ; The results are shown in Table 3.

[0028] Control Example 3 A method for preparing Baizi Yangxin Tablets, comprising the following steps: 32 g of cinnamon, 32 g of Codonopsis pilosula, and 90 g of fermented Pinellia ternata are pulverized into fine powder; 38 g of cinnabar is levigated into extremely fine powder; 128 g of Angelica sinensis, 128 g of Ligusticum wallichii, and 32 g of Platycladus orientalis seeds are used as solvents with 70% ethanol, impregnated for 24 hours, percolated, and about 1500 ml of percolate is collected, and the ethanol is recovered; 32 g of Schisandra chinensis vinegar-processed and 32 g of Polygala tenuifolia processed are used as solvents with 60% ethanol, impregnated for 24 hours, percolated, and about 320 ml of percolate is collected, and the ethanol is recovered; the remaining 38 g of fermented Pinellia ternata and the two kinds of medicated residues after percolation above are decocted twice with 128 g of Astragalus membranaceus roasted, 13 g of Glycyrrhiza uralensis roasted, 256 g of Poria cocos, and 32 g of Ziziphus jujuba var. spinosa for 2 hours each time, and the decoction is filtered. The percolates are combined, combined with the above-mentioned medicinal liquids, concentrated to a density of 1.153 (58 °C) and a weight of 390 g, and the fine powder of cinnamon, Codonopsis pilosula, and fermented Pinellia ternata is added and mixed evenly. The mixed materials are divided into two parts, and are dried respectively by a vacuum dryer and a vacuum microwave dryer. When drying, the materials need to be evenly spread on a stainless steel tray, 2 - 4 kg / tray; the stainless steel tray containing 55% of the materials is sent into the vacuum dryer for drying. The temperature of the vacuum dryer is set at 70 °C and the vacuum degree is ≤ 0.04 Mpa (slowly increase the vacuum degree to 0.08 Mpa) to control the water content of the dry extract to 4 - 6%; the stainless steel tray containing 45% of the materials is sent into the vacuum microwave dryer for drying. The temperature of the vacuum microwave dryer is set at 50 °C and the vacuum degree is ≤ 0.04 Mpa. After 40 minutes, the vacuum degree is adjusted to 0.08 Mpa to control the water content of the dry extract to about 5%; the dry extract after the new drying method is pulverized and mixed evenly, then the extremely fine powder of cinnabar is added and mixed evenly. According to the state of the materials, 23 g of water is added for granulation, dried, and pressed into 1000 tablets, and sugar-coated to obtain the product. For the specific physical object, see Figure 8 ; The results are shown in Table 3 Table 3 Comparison of Each Example and Comparative Example , It should be noted that the above-mentioned examples and comparative examples are all tested in parallel three times, and the data in Table 3 are the averages of the three tests.

[0029] It can be seen from Table 3 that if the extract is all dried by vacuum drying (Comparative Example 1), the content of ferulic acid is extremely low and cannot meet the standard; if the extract is all dried by vacuum microwave drying (Comparative Example 2), the content of mercury sulfide cannot meet the standard and the formability is poor; when 40% - 50% of the extract is dried by vacuum microwave drying and the remaining extract is dried by vacuum drying, the content indexes can all meet the standard, and adding an appropriate amount of syrup for granulation can enhance the formability of the plain tablets.

[0030] The above are only the preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions, and improvements made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A new method for preparing Baizi Yangxin tablets, characterized in that, It includes the following steps: (1) Cinnamon, Codonopsis pilosula, part of Rhizoma Pinelliae Praeparatum, cinnabar, Angelica sinensis, Ligusticum wallichii, Semen Platycladi are percolated, the percolate is collected, and ethanol is recovered; (2) Schisandra chinensis (Turcz.) Baill. var. chinensis f. acida and Polygala tenuifolia Willd. var. wilsonii (Hoffm.) Hsiao et K. C. Hsia are percolated, the percolate is collected, and ethanol is recovered; (3) The remaining Rhizoma Pinelliae Praeparatum and the medicinal residues after the above two percolations are decocted with Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao, Glycyrrhiza uralensis Fisch. var. glandulifera Regel et Herd., Poria cocos (Schw.) Wolf, and Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chow, the decoction is filtered, and the percolates are combined; (4) The medicinal liquids in steps (1), (2), and (3) are combined, concentrated, fine powders of cinnamon, Codonopsis pilosula, and Rhizoma Pinelliae Praeparatum are added, and they are mixed evenly to obtain the material to be dried; (5) For the material to be dried obtained in step (4), 40wt% - 50wt% is subjected to microwave vacuum drying, and the remaining material is subjected to vacuum drying to obtain dry extracts respectively, and they are mixed and pulverized to obtain extract powder; (6) The extract powder obtained in step (5) is granulated to obtain the product.

2. The method according to claim 1, wherein In step (5), the method of microwave vacuum drying is as follows: The extract is evenly loaded into the baking tray of the microwave vacuum dryer at 2.0 - 4.0 kg / tray, the temperature is set at 45 - 55°C, the vacuum degree is ≤ 0.08 Mpa, and the time is 75 - 90 min.

3. The method according to claim 2, wherein The microwave vacuum drying temperature is 50°C.

4. The method according to claim 1, wherein In step (5), the method of vacuum drying is as follows: The extract is evenly loaded into the baking tray of the vacuum drying oven at 2.0 - 4.0 kg / tray, the temperature is set at 60 - 80°C, the vacuum degree is ≤ 0.08 Mpa, and the time is 14 - 16 h.

5. The method according to claim 4, wherein The vacuum drying temperature is 70°C.

6. The method according to claim 1, characterized in that, In step (5), the water content of the dry extracts after microwave vacuum drying and vacuum drying is controlled at 4 - 6wt%.

7. The method according to claim 1, characterized in that, In step (6), syrup is added during granulation.

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