Freeze-dried microsphere filling equipment and filling method

Abstract

The invention discloses freeze-dried microsphere filling equipment and a filling method, and relates to the field of assembly equipment, and the freeze-dried microsphere filling equipment sequentially comprises a cover body, a material distribution disc, a feeding pipe, a first fixed seat, a baffle plate, a push plate, a second fixed seat, a carrier and a base from top to bottom, the ball distributing channel comprises a material groove, a first discharging hole, a feeding pipe, a second discharging hole, a first material passing hole, a second material passing hole and a third discharging hole. According to the device, freeze-dried microspheres can be filled into a plurality of reaction tanks of a filled piece, manual ball separation by using tweezers is not needed, the ball separation efficiency can be improved, a large amount of labor is reduced, and pollution is reduced. Particularly, a filled piece for multi-joint detection molecule detection can be used for classifying and filling different types of freeze-dried microspheres in one step, so that the problem that the freeze-dried microspheres need to be placed by a plurality of persons according to working procedures due to a plurality of project types is solved.

Description

Technical Field

[0001] The present invention relates to the field of assembly equipment, and specifically to a freeze-dried microsphere filling equipment and a filling method thereof. Background Art

[0002] In the prior art, the freeze-dried microspheres of microfluidic reagent cards are all manually separated by tweezers in a humidity-controlled environment, with extremely low efficiency, requiring a large number of workers, and being prone to reagent contamination, resulting in inaccurate testing. Especially in some multiplex molecular detection reagent cards, in order to achieve the goal of making a basic diagnosis of suspected infection symptoms of one or more different pathogens with one sample and one test, it is necessary to fill different multiplex detection items of freeze-dried microspheres in the same molecular detection reagent card at the same time, resulting in cumbersome production processes and requiring a large amount of manual precise dispensing and production. In addition, due to the low production efficiency, workers need to work in a low-humidity environment for a long time, which is prone to uncomfortable reactions and cannot meet the requirements of mass production. Therefore, a device for filling freeze-dried microspheres is proposed. Summary of the Invention

[0003] The purpose of the present invention is to provide a freeze-dried microsphere filling equipment and a filling method thereof, aiming to overcome the above problems existing in the prior art.

[0004] To achieve the purpose, the present invention provides the following technical solutions: A freeze-dried microsphere filling equipment includes a material distribution plate, a feeding pipe, a first fixing seat, a pushing plate, a second fixing seat, a carrier and a base. A plurality of material grooves are provided at the upper end of the material distribution plate, and a first discharge hole is provided in the material groove. A plurality of second discharge holes are vertically extended in the first fixing seat, and the upper end of each second discharge hole is communicated with the first discharge hole through a feeding pipe; The second fixing seat is fixed on the upper end of the base, the carrier is movably arranged between the second fixing seat and the base, the first fixing seat is fixed on the upper end of the second fixing seat, and there is an interlayer space between the first fixing seat and the second fixing seat, and the pushing plate is movably arranged in the interlayer space; The pushing plate is provided with a sealing plate and a second material passing hole for each second discharge hole; the second fixing seat is provided with a third discharge hole for each second material passing hole, and the lower end of each third discharge hole corresponds to a reaction groove of the part to be filled; by moving the pushing plate, the freeze-dried microspheres falling from the second discharge hole into the second material passing hole are transferred to the third discharge hole and finally fall into the reaction groove of the part to be filled.

[0005] Further, an annular groove is provided around each group of sealing plates and second material passing holes at the upper end of the pushing plate.

[0006] Further, a guiding bar is provided at the lower end of the above-mentioned pushing plate, and a guiding groove is provided at the upper end of the above-mentioned second fixing seat. The guiding bar is movably embedded in the guiding groove; the pushing plate is provided with a first strip-shaped hole, and the upper end of the second fixing seat is provided with a limiting post, and the upper end of the limiting post is movably embedded in the first strip-shaped hole.

[0007] Further, the above-mentioned third discharge hole includes a first vertical section, an inclined section and a second vertical section from top to bottom.

[0008] Further, a plurality of the above-mentioned material grooves are annularly distributed on the material distribution plate. The inner side wall of the material groove is funnel-shaped, and a discharge channel extending inward is provided at the tip of the funnel shape. The end of the discharge channel is connected to the upper end of the first discharge hole.

[0009] Further, it further includes a baffle plate. The above-mentioned baffle plate is movably arranged at the lower end of the first fixing seat. The baffle plate is provided with a first material passing hole for each first discharge hole; the first discharge hole is communicated with the second material passing hole through the first material passing hole; a blocking portion is provided at the edge of the above-mentioned first material passing hole; by moving the baffle plate, the blocking portion is moved below the first material passing hole to block the freeze-dried microspheres.

[0010] Furthermore, the above-mentioned blocking portion is a spherical concave surface, which is a chamfer provided at the edge of the first material passing hole.

[0011] Furthermore, it further includes spring screws. The above-mentioned baffle plate is provided with a plurality of second strip-shaped holes, and the baffle plate is assembled to the lower end of the first fixing seat by the spring screws passing through the second strip-shaped holes.

[0012] Further, the above-mentioned carrier is movably arranged at the upper end of the base through a linear slide rail.

[0013] Further, a plurality of mounting posts are provided at the upper end of the above-mentioned base, and the second fixing seat and the first fixing seat are detachably fixed to the plurality of mounting posts.

[0014] Further, a plurality of the above-mentioned material grooves are annularly distributed; it further includes a cover body. The above-mentioned cover body is provided with a feeding port (21), and the cover body is rotatably arranged at the upper end of the material distribution plate; by rotating the cover body, the feeding port is directed to any one of the above-mentioned material grooves.

[0015] A method for loading freeze-dried microspheres, using the freeze-dried microsphere loading device with the above-mentioned structure, includes the following steps: S1. Add the freeze-dried microspheres into each material groove; then a plurality of freeze-dried microspheres fall into the feeding pipe, the second discharge hole and the second material passing hole one by one, and are stacked in a column therein; S2. Move the pushing plate towards the third discharge hole, push the second material passing hole and the freeze-dried microspheres inside it to the upper part of the third discharge hole. The freeze-dried microspheres fall into the third discharge hole under the action of gravity and are finally loaded into the reaction tank; at the same time, the sealing plate blocks the remaining freeze-dried microspheres.

[0016] S3. Move the push plate back towards the second material passing hole, and the freeze-dried microspheres blocked by the sealing plate will fall into the third discharge hole accordingly. S4. Remove the carrier and take out the loaded component.

[0017] Furthermore, the following steps are also included: When it is necessary to clean large pieces of freeze-dried microsphere debris or repair components, move the baffle towards the third discharge hole, and the first material passing hole and the freeze-dried microspheres above it will be blocked by the blocking part; then disassemble the baffle and other components above it together.

[0018] The present invention has the following beneficial effects compared with the prior art: The present invention can fill the reaction grooves of the loaded component with freeze-dried microspheres, eliminating the need for manual ball separation with tweezers by workers. It can improve the ball separation efficiency, reduce a large amount of manual labor, and reduce pollution. Especially for the multi-assay molecular detection reagent card, different types of freeze-dried microspheres can be classified and loaded in one step, reducing the problem of multiple workers arranging freeze-dried microspheres according to procedures due to a large number of project types. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a three-dimensional structure schematic diagram of the present invention, including the loaded component.

[0020] Figure 2 It is a left view of the present invention.

[0021] Figure 3 It is an exploded view of the present invention, including the loaded component.

[0022] Figure 4 It is a structural schematic diagram of the material distribution plate in the present invention.

[0023] Figure 5 It is a schematic diagram of the bottom structure of the material distribution plate in the present invention.

[0024] Figure 6 It is a structural schematic diagram of the baffle in the present invention, including spring screws.

[0025] Figure 7 It is a structural schematic diagram of the push plate in the present invention.

[0026] Figure 8 It is a structural schematic diagram of the second fixing seat in the present invention.

[0027] Figure 9 It is a schematic diagram of the bottom structure of the second fixing seat in the present invention.

[0028] Figure 10 It is a structural schematic diagram of a loaded component.

[0029] Figure 11In the present invention, it is a schematic structural diagram of a vehicle and a base.

[0030] Figure 12 It is a partial cross-sectional view of the present invention in Working State 1. Among them, the baffle is in Figure 6 the Q1 position shown, that is, one end of the first material passing hole is located below the second material discharging hole; the push plate is in the pulled-out state, and the second material passing hole is located below the second material discharging hole.

[0031] Figure 13 It is a partial cross-sectional view of the present invention in Working State 2.

[0032] Figure 14 It is a partial cross-sectional view of the present invention in the non-working state. Specific Embodiments

[0033] The following describes the specific embodiments of the present invention with reference to the accompanying drawings. To fully understand the present invention, many details are described below, but for those skilled in the art, the present invention can be implemented without these details.

[0034] As Figures 1 - 14 shown, a freeze-dried microsphere loading device includes a cover body 2, a material distribution plate 3, a feeding pipe 4, a first fixing seat 5, a baffle 6, a push plate 7, a second fixing seat 8, a vehicle 9 and a base 10. A plurality of material grooves 31 are provided at the upper end of the material distribution plate 3, and a first material discharging hole 33 is provided in the material groove 31. A plurality of second material discharging holes 51 are vertically extended and provided on the first fixing seat 5, and each second material discharging hole 51 is communicated with the first material discharging hole 33 through a feeding pipe 4.

[0035] The second fixing seat 8 is fixed on the upper end of the base 10, the vehicle 9 is movably arranged between the second fixing seat 8 and the base 10, the first fixing seat 5 is fixed on the upper end of the second fixing seat 8, and there is a sandwich space 508 between the first fixing seat 5 and the second fixing seat 8, and the push plate 7 is movably arranged in the sandwich space 508.

[0036] The push plate 7 is provided with a sealing plate 72 and a second material passing hole 71 for each second material discharging hole 51; the second fixing seat 8 is provided with a third material discharging hole 81 for each second material passing hole 71, and the lower end of each third material discharging hole 81 corresponds to a reaction groove a1 of the to-be-loaded part a; by moving the push plate 7, the freeze-dried microspheres falling from the second material discharging hole 51 into the second material passing hole 71 are transferred to the third material discharging hole 81 and finally fall into the reaction groove a1 of the to-be-loaded part a.

[0037] As Figure 3 and Figure 10 shown, the to-be-loaded part a includes, but is not limited to, a microfluidic reagent card.

[0038] As Figures 1 - 5 , and Figure 12As shown, the number of the material troughs 31 is the same as that of the reaction troughs a1 of the loaded parts a, and they are in one-to-one correspondence, including but not limited to sixteen. Preferably, the sixteen material troughs 31 are annularly distributed on the material distributing plate 3. The inner side wall of the material trough 31 is funnel-shaped, and a discharge channel 33 is arranged to extend inwards at the tip of the funnel shape. The end of the discharge channel 33 extends vertically to be provided with a first discharge hole 33, that is, the end of the discharge channel 33 is communicated with the upper end of the first discharge hole 33. The lower end of the discharge channel 33 is an inclined surface, which is convenient for using gravity to make the freeze-dried microspheres b roll towards the first discharge hole 33.

[0039] It should be noted that the sizes of the discharge channel 33 and the first discharge hole 33 are adapted to the freeze-dried microspheres b, that is, only one freeze-dried microsphere b can pass through.

[0040] As Figures 1 - 5 , and Figure 12 shown, preferably, the upper and lower ends of the feeding pipe 4 are respectively inserted into the inside of the first discharge hole 33 and the second discharge hole 51.

[0041] As Figures 1 - 4 shown, the cover body 2 is provided with a feeding port 21, and the cover body 2 is rotatably arranged at the upper end of the material distributing plate 3; by rotating the cover body 2, the feeding port 21 is directed to any one of the material troughs 31, so as to feed different material troughs 31 and prevent mixing of materials.

[0042] In a specific embodiment, the cover body 2 is rotatably arranged at the upper end of the material distributing plate 3, and is specifically realized by the following structure: a connecting piece 1 is fixedly arranged at the lower end of the cover body 2. The connecting piece 1 is a disc body with shaft bodies at both the upper and lower ends. The disc body is fixedly arranged at the lower end of the cover body 2, and the shaft body at its upper end extends above the cover body 2 to form a hand-held part for lifting and rotating the cover body 2, and the shaft body at its lower end is rotatably inserted into the material distributing plate 3.

[0043] As Figures 1 - 3 , and Figure 12 shown, preferably, the cover body 2, the feeding pipe 4, and the first fixing seat 5 are light-transmissive, including but not limited to transparent plastic products or acrylic products, which is convenient for personnel to observe the internal situation of the device. The material distributing plate 3, the baffle 6, the pushing plate 7, the second fixing seat 8, the base 10, and other connecting parts are all made of metal materials. By contacting the desktop of the workbench, grounding and static elimination treatment is carried out to overcome the interference of static electricity on the freeze-dried microspheres and improve the efficiency of sphere separation.

[0044] As Figures 1 - 6 , and Figure 13 , Figure 14As shown, the baffle 6 is movably arranged at the lower end of the first fixing base 5. The baffle 6 is provided with a first material passing hole 61 for each first discharge hole 33, and a blocking portion 62 is arranged at the edge of the first material passing hole 61. The first discharge hole 33 is communicated with the second material passing hole 71 through the first material passing hole 61. During use, by moving the baffle 6, the blocking portion 62 can be moved to the lower part of the first material passing hole 61 to block the freeze-dried microspheres b from falling down, so that the freeze-dried microspheres b can be temporarily stored inside the second discharge hole 51 and the feeding pipe 4.

[0045] As Figure 2 , Figure 6 , Figure 13 and Figure 14 shown, in a specific embodiment, the baffle 6 is movably arranged at the lower end of the first fixing base 5, which is specifically realized by the following structure: the baffle 6 is provided with a plurality of second strip holes 63, and the baffle 6 is assembled at the lower end of the first fixing base 5 by spring screws 601 passing through the second strip holes 63. Due to the existence of the spring screws 601, when a relatively large external force is applied, the baffle 6 assembled on the first fixing base 5 can be moved and adjusted along the second strip holes 63. Specifically: in the working state, the baffle 6 is moved to the position Q1. At this time, the material falling end 611 of the first material passing hole 61 is below the second discharge hole 51, and the freeze-dried microspheres b can fall into the first material passing hole 61. In the non-working state (such as when maintenance is required), the baffle 6 is moved to the position Q2. At this time, the blocking portion 62 is below the second discharge hole 51, and the material falling end 611 of the first material passing hole 61 is offset from the second discharge hole 51 to a certain extent. The freeze-dried microspheres b are blocked inside the second discharge hole 51 by the blocking portion 62, which is convenient for ensuring that the freeze-dried microspheres b will not fall when the baffle 6 and other components above it need to be disassembled together.

[0046] As Figure 13 and Figure 14 shown, preferably, the blocking portion 62 is a spherical concave surface, which is a chamfer arranged at the edge of the first material passing hole 61. Such a design can make the edge of the blocking portion 62 connecting the first material passing hole 61 thinner. During the process of the blocking portion 6 moving to the position Q2 with the baffle 6, it can extend into the bottom of the freeze-dried microspheres b, slightly lift the freeze-dried microspheres b and then block them above the blocking portion 6.

[0047] As Figures 1 - 13 shown, in a specific embodiment, the push plate 7 is movably arranged in the sandwich space 508, which is specifically realized by the following structure: a guiding strip 76 is arranged at the lower end of the push plate 7, and a guiding groove 82 is arranged at the upper end of the second fixing base 8. The guiding strip 76 is movably embedded in the guiding groove 82.

[0048] Preferably, in order to enable the push plate 7 to Figure 12 and Figure 13A travel limit mechanism is also provided between the push plate 7 and the second fixed seat 8 of the push plate 7. Specifically, the push plate 7 is provided with a first strip hole 74, and a limit column 84 is provided at the upper end of the second fixed seat 8. The upper end of the limit column 84 is movably embedded in the first strip hole 74. By moving the push plate 7, the limit column 84 is moved back and forth between the two ends of the first strip hole 74.

[0049] That is, when in use, the push plate 7 is moved so that the limiting column 84 is at one end of the first strip hole 74. Figure 12 As shown, the second feeding hole 71 is located below the second discharging hole 51 and the drop end 611 of the first feeding hole 61, and the freeze-dried microspheres b can fall into the first feeding hole 61. Move the push plate 7 in the reverse direction so that the limiting column 84 is at the other end of the first strip hole 74. Figure 13 As shown, the second feeding hole 71 carries the freeze-dried microspheres b and moves to the top of the third discharging hole 81. The freeze-dried microspheres b then fall into the third discharging hole 81 and then fall into the reaction tank a1 of the filled component a, completing the filling.

[0050] It should be noted that, since the second feed hole 71 will carry the freeze-dried microspheres b and the upper ends of the freeze-dried microspheres b are still in the first feed hole 61, in order to avoid the freeze-dried microspheres b, the first feed hole 61 is extended toward the third discharge hole 81 to form a yielding end 612, so that the entire first feed hole 61 is in the shape of a long strip.

[0051] like Figure 7 As shown, preferably, an annular groove 73 is provided at the upper end of the push plate 7 around each set of sealing plates 72 and the second feeding hole 71. The freeze-dried microspheres b may produce fragments due to collision during falling or movement, or due to other reasons. At this time, the annular groove 73 can collect the fragments to prevent excessive fragments from affecting the feeding or affecting the movement of the push plate 7.

[0052] like Figure 7 As shown, a handle 75 is provided at one end of the push plate 7 to facilitate moving the push plate 7.

[0053] like Figure 3 , Figure 10 , Figure 7 and Figure 13As shown, preferably, the third discharge hole 81 includes a first vertical section 811, an inclined section 812, and a second vertical section 813 from top to bottom. The first vertical section 811 allows the freeze-dried microspheres b to quickly fall when moving to the third discharge hole 81 along with the second feeding hole 71, vacating the second feeding hole 71, thereby allowing the operator to move the push plate 7 back to carry the next batch of freeze-dried microspheres b, improving the efficiency of ball separation. The inclined section 812 can make the speed of the freeze-dried microspheres b appropriate, preventing the freeze-dried microspheres b from falling vertically and causing fragmentation, bouncing, etc. The second vertical section 813 can make the freeze-dried microspheres b accurately fall into the reaction tank a1.

[0054] As Figure 1 , Figure 2 and Figure 11 shown, in a specific embodiment, the carrier 9 is movably arranged between the second fixed seat 8 and the base 10, and is specifically implemented by the following structure: The carrier 9 is movably arranged on the upper end of the base 10 through a linear slide rail 103. Of course, the base 10 is provided with limit members 102 at the front and rear ends of the linear slide rail 103. The carrier 9 is provided for positioning and placing the loaded part a, and is also provided with a convenient handle 92.

[0055] As Figure 1 , Figure 2 and Figure 11 shown, in a specific embodiment, four mounting posts 101 are provided on the upper end of the base 10, and the second fixed seat 8 and the first fixed seat 5 are detachably fixed to the four mounting posts 101, which is convenient for loading and unloading. Of course, the number of the mounting posts 101 is not limited to four and can be increased or decreased according to needs.

[0056] As Figures 1 to 14 shown, the usage method of the present invention is as follows (S1), as needed, add the freeze-dried microspheres b to each material tank 31, so that the freeze-dried microspheres b fall into the feeding pipe (4), the second discharge hole (51), the first feeding hole (61), and the second feeding hole (71) one by one, and accumulate in a column therein.

[0057] (S2), move the push plate (7) towards the third discharge hole (81), and push the second feeding hole (71) and the freeze-dried microspheres (b) inside it to the upper part of the third discharge hole 81; the freeze-dried microspheres (b) fall into the third discharge hole 81 under the action of gravity and are finally loaded into the reaction tank (a1); at the same time, the sealing plate 72 blocks the remaining freeze-dried microspheres b.

[0058] (S3), move the push plate 7 back towards the second feeding hole 71, and the freeze-dried microspheres b blocked by the sealing plate 72 will fall into the third discharge hole 81 accordingly.

[0059] (S4), move out the carrier 9 and take out the loaded part a.

[0060] (S6), place another unloaded loaded part a, and repeat steps (2)-(4).

[0061] (S7), when it is necessary to clean large pieces of freeze-dried microsphere powder or repair parts, move the baffle 6 towards the third discharge hole 81, and use the blocking part 62 to block the first material passing hole 61 and the freeze-dried microspheres b above it therein; then disassemble the baffle 6 and other parts above it from the mounting post 101 together for cleaning or repair operations, etc., without pouring out the freeze-dried microspheres b above the first material passing hole 61.

[0062] The above is only the specific embodiment of the present invention, but the design concept of the present invention is not limited thereto. Any non-substantive modification made to the present invention using this concept shall fall within the scope of infringement of the protection scope of the present invention.

Claims

1. A freeze-dried microsphere filling device, characterized in that: It includes a material distribution plate (3), a feeding pipe (4), a first fixing seat (5), a push plate (7), a second fixing seat (8), a carrier (9) and a base (10). A plurality of material grooves (31) are provided at the upper end of the material distribution plate (3), and a first discharge hole (33) is provided in the material groove (31). A plurality of second discharge holes (51) are vertically extended and provided in the first fixing seat (5), and the upper end of each second discharge hole (51) is communicated with the first discharge hole (33) through a feeding pipe (4). The second fixing seat (8) is fixed to the upper end of the base (10). The carrier (9) is movably arranged between the second fixing seat (8) and the base (10). The first fixing seat (5) is fixed to the upper end of the second fixing seat (8), and there is an interlayer space (508) between the first fixing seat (5) and the second fixing seat (8). The push plate (7) is movably arranged in the interlayer space (508). The push plate (7) is provided with a sealing plate (72) and a second material passing hole (71) for each second discharge hole (51). The second fixing seat (8) is provided with a third discharge hole (81) for each second material passing hole (71), and the lower end of each third discharge hole (81) corresponds to a reaction groove (a1) of the to-be-filled part (a). By moving the push plate (7), the freeze-dried microspheres falling from the second discharge hole (51) into the second material passing hole (71) are transferred to the third discharge hole (81) and finally fall into the reaction groove (a1).

2. The freeze-dried microsphere filling device according to claim 1, characterized in that: An annular groove (73) is provided at the upper end of the push plate (7) around each group of the sealing plate (72) and the second material passing hole (71).

3. The freeze-dried microsphere loading device according to claim 1, characterized in that: A guiding strip (76) is provided at the lower end of the push plate (7), and a guiding groove (82) is provided at the upper end of the second fixing seat (8). The guiding strip (76) is movably embedded in the guiding groove (82). A first strip-shaped hole (74) is provided on the push plate (7), and a limiting post (84) is provided at the upper end of the second fixing seat (8). The upper end of the limiting post (84) is movably embedded in the first strip-shaped hole (74).

4. The freeze-dried microsphere filling device according to claim 1, characterized in that: The third discharge hole (81) includes a first vertical section (811), an inclined section (812) and a second vertical section (813) from top to bottom.

5. A freeze-dried microsphere filling device according to claim 1, characterized in that: A plurality of the material grooves (31) are annularly distributed on the material distribution plate (3). The inner side wall of the material groove (31) is funnel-shaped, and a discharge channel (33) is provided at the tip of the funnel-shaped part and extends inwards. The end of the discharge channel (33) is communicated with the upper end of the first discharge hole (33).

6. The freeze-dried microsphere filling device according to claim 1, wherein: It further includes a baffle (6). The baffle (6) is movably arranged at the lower end of the first fixing seat (5). The baffle (6) is provided with a first material passing hole (61) for each first discharge hole (33). The first discharge hole (33) is communicated with the second material passing hole (71) through the first material passing hole (61). A blocking part (62) is provided at the edge of the first material passing hole (61). By moving the baffle (6), the blocking part (62) is moved to the lower part of the first material passing hole (61) to block the freeze-dried microspheres.

7. A freeze-dried microsphere filling device according to claim 6, characterized in that: The blocking part (62) is a spherical concave surface and is a chamfer provided at the edge of the first material passing hole (61).

8. A freeze-dried microsphere filling device according to claim 6, characterized in that: It further includes spring screws (601). The baffle (6) is provided with a plurality of second strip-shaped holes (63), and the baffle (6) is assembled to the lower end of the first fixing base (5) by the spring screws (601) passing through the second strip-shaped holes (63).

9. A freeze-dried microsphere filling device according to claim 1, characterized in that: A plurality of the material grooves (31) are annularly distributed; it further includes a cover body (2). The cover body (2) is provided with a feeding port (21), and the cover body (2) is rotatably arranged at the upper end of the material distribution plate (3); by rotating the cover body (2), the feeding port (21) is directed to any one of the material grooves (31).

10. A freeze-dried microsphere filling device according to claim 1 or 9, characterized in that: A plurality of mounting posts (101) are provided at the upper end of the base (10), and the second fixing base (8) and the first fixing base (5) are detachably fixed to the plurality of mounting posts (101).

11. A method for loading freeze-dried microspheres, characterized in that: Using the freeze-dried microsphere filling device according to any one of claims 1-10, the following steps are included: S1. Add the freeze-dried microspheres (b) into each material groove (31); then a plurality of freeze-dried microspheres (b) fall into the feeding pipe (4), the second discharge hole (51) and the second material passing hole (71) one by one, and are stacked in a column therein; S2. Move the push plate (7) towards the third discharge hole (81) to push the second material passing hole (71) and the freeze-dried microspheres (b) therein to the upper part of the third discharge hole (81). The freeze-dried microspheres (b) fall into the third discharge hole (81) under the action of gravity and are finally filled into the reaction tank (a1); meanwhile, the sealing plate (72) blocks the remaining freeze-dried microspheres (b). S3. Move the push plate (7) back towards the second material passing hole (71), and the freeze-dried microspheres (b) blocked by the sealing plate (72) fall into the third discharge hole (81) accordingly; S4. Move out the carrier (9) and take out the loaded part (a).

12. A method for loading freeze-dried microspheres according to claim 11, characterized in that: Using the freeze-dried microsphere filling device according to any one of claims 6-8, the following steps are further included: when it is necessary to clean large pieces of freeze-dried microsphere powder or repair parts, move the baffle (6) towards the third discharge hole (81), and the blocking part (62) blocks the first material passing hole (61) and the freeze-dried microspheres (b) above it therein; then disassemble the baffle (6) and other parts above it together.

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